Plague  —n. 1 deadly contagious disease. 2 (foll. By of) colloq. Infestation of a pest etc. 3 great trouble or affliction. 4 colloq. Nuisance. —v. (plagues, plagued, plaguing) 1 colloq. Pester, annoy. 2 afflict, hinder (plagued by back pain). 3 affect with plague. [latin plaga stroke, infection]