Manipulate  v. (-ting) 1 handle, esp. With skill. 2 manage (a person, situation, etc.) To one's own advantage, esp. Unfairly. 3 move (part of a patient's body) by hand in order to increase flexion etc. 4 computing edit or move (text, data, etc.).  manipulable adj. Manipulation n. Manipulator n. [latin manus hand]