In vivo uptake of fluoride by surface enamel of cleaned and plaque-covered teeth. Utilizing a newly developed biopsy method, the F uptake in the outer 3 mum of enamel from a single topical application of neutral NaF or amine F solution was tested on cleaned and plaque-covered premolars in 12- to 14-year-old children. Cleaned teeth treated with neutral NaF acquired only insignificant amounts of F. The presence of plaque seemed to enhance the deposition of F in surface enamel. The findings were discussed in relation to the possible mechanisms of action of topically applied fluorides. Topical treatments with amine F increased surface enamel F considerably more than the NaF. The F uptake was similar in cleaned and plaque-covered teeth. It was suggested that the usually performed plaque-removing procedures prior to topical F applications are superfluous and may even be disadvantageous.


Effect of fluoride on protein and collagen biosynthesis in rabbit dental pulp in vitro. The time course for incorporation of KC-proline into various fractions of rabbit dental pulp in vitro has been measured. In the TCA-soluble precursor pool a steady state level of activity was indicated upon incubation after 3 h, whereas incorporation into protein and 14C-hydroxyproline, i.e. collagen formation, increased linearly for 9 h, leveling off upon further incubation. A lag period of about 3 h was indicated for the appearance of high molecular weight 14C-activity, including 14C-hydroxyproline, in the medium, increasing linearly from 3 h to the end of the incubation period (22 h). In this system, fluoride exhibited a dose-dependent inhibitory effect. At 5.3 mM fluoride the uptake of 14C-proline into the TCA-soluble pool was inhibited by about 50%, and the incorporation into protein and the subsequent conversion to hydroxyproline by about 90 and 60%, respectively. Release of collagen, i.e. 14C-hydroxyproline-containing material, seemed to be the process most sensitive to fluoride; it was inhibited by about 50% at the lowest concentration (1.3 mM) tested.


Influence of maturation status and tooth type of permanent teeth upon electrometric and thermal pulp testing. The threshold values of developing teeth were determined for two commonly used electrometric pulp testers (Siemens Sirotest and Bofors Pulp Tester) and a new thermal test based on carbon dioxide snow (Odontotest). The teeth examined were divided into 7 stages according to maturation status. This study showed that teeth in Stages 3-5, i.e. until completion of root formation, show an increased electrometric threshold value. The Siemens tester appeared to be equal to the Bofors tester with regard to reliability. The Odontotest was the most reliable method examined, giving a consistent positive response in all examined teeth.


Influence of splints and temporary crowns upon electric and thermal pulp-testing procedures. The influence of different splints and temporary crowns upon the reliability of electric and thermal pulp-testing procedures was examined in 10 patients with vital maxillary central incisors and 10 patients with vital maxillary central incisors and 10 patients with unilateral pulp necrosis of a central incisor. The pulp-testing procedures were: (1) Bofors Pulp Tester, (2) Siemens Sirotest, (3) heated guttapercha, (4) ice, and (5) carbon dioxide snow (Odontotest). The splints or temporary crowns were: (1) silver cap splint, (2) acrylic cap splint, (3) Hawley orthodontic plate, (4) Saur's arch bar, (5) orthodontic bands, (6) stainless steel crown, and (7) stainless steel crown with labial surface removed. A reliable electrometric pulp response could only be elicited if the pulp tester was applied directly upon enamel and preferably upon the incisal edge. In this instance metal splints or partial steel crowns applied to the tooth had no effect on the pain threshold. A false positive reaction in case of pulp necrosis was only elicited when the electrode was placed directly upon metal which contacted neighboring vital teeth. The use of ice and heated guttapercha appeared to be of limited value, due to inconsistent pulp responses. Carbon dioxide snow gave a reliable response, unless applied on the incisal edge.


Intraoral spread of the antimicrobial effect of a chlorhexidine gel. The aim of the study was to determine the range of the antimicrobial effect of Hibitane Dental Gel (ICI, Macclesfield, England), containing 1% chlorhexidine, when used as a dentifrice while brushing. A standard toothpaste with no claim for antibacterial activity (Pepsodent) was used as a control. Twenty-four dental students brushed their teeth during two 4-day periods using the closed mouth technique, i.e. they kept their teeth tightly clenched and brushed only the facial tooth surfaces twice daily. Before and after each test period the lingual and linguomesial surfaces of the mandibular teeth were scored for clearly visible plaque. The facially applied chlorhexidine gel had no more effect on plaque growth lingually than the standard toothpaste which was used as control. The lack of effect of the gel was suggested to be due to an insufficient spread and penetration capacity of its antimicrobial component.


Mandibular kinesthesia in fatigue of human jaw muscles. Fatigue was developed by four human subjects after negative work, and by two subjects after negative/positive work by the jaw muscles. Another four subjects did not develop fatigue subsequent to muscular exercise. In subjects with fatigue, the ability to perceive and/or produce repetitively a predetermined mandibular posture, i.e. mandibular kinesthesia, was impaired by about 285%. It is suggested that the distorted kinesthesia resulted from either a fatigue-induced failure of, or a fatigue-induced persistence of, jaw muscle fibers to contract, which in turn led to distorting flows of afferent impulses from muscles spindles and/or tendon organs.


Facial pain in negative and positive work of human jaw muscles. Ten healthy human male subjects with a mean age of 21 years performed negative and negative/positive work with the jaw muscles for about 21 min. The average amount of negative work was 13.3 kgm, while that of negative/positive work was 48.5 kgm. Eight subjects developed either spontaneous or provoked facial pain subsequent to the exercise. No positive correlations were demonstrated between the total number of facial pain sites and the amounts of work and power of the muscles, nor between the number of pain sites and the speed of mandibular movement. It is suggested that the appearance of facial pain was associated with the pre-experimental strength and conditioning of the jaw muscles.


On the solubility of zinc in the gamma-phase of the silver-mercury system. By measuring lattice constants of a number of Ag-Hg-Zn alloys with gamma-phase structure, it has been shown that apart from a possible two-phase field there exists a continuous solid solution between gamma (Ag-Hg) and gamma (Ag-Zn). A correlation between the Zn-content in the gamma 1 phase in set dental silver amalgam and the Zn-content in the corresponding alloy has been determined.


The effect of vincristine on dentinogenesis in the rat incisor. A preliminary report on the histomorphologic effects of vincristine on rat incisor dentinogenesis is presented. Niche-like areas of osteodentin and a faint incremental line in the dentin were the main derangements observed after single injections of the drug. The severity of the lesions was dose-dependent.


Allergy tests against formaldehyde, cresol, and eugenol in children with formocresol pulpotomized primary teeth. One hundred and twenty-eight children in the age range 5-14 years with formocresol pulpotomized teeth were tested for sensitivity againist formaldehyde, eugenol, and cresol using the patch test. The number of treated teeth on each child varied from one to six and the time between the pulpotomy and patch test varied from 2 months to 8 years. None of the children showed positive results.


Fluoride release from a fluoride-containing amalgam and two luting cements. The release of fluoride from an amalgam and two luting cements, silicophosphate and polycarboxylate, was studied by shaking test specimens in a solution with hydroxyapatite, and measuring the fluoride taken up by the apatite. The initial release was significant for all three materials. After 1 week the amalgam released only minor amounts of fluoride, whereas the cements continued to liberate fluoride during the 5-week observation time to the same extent as silicates in earlier studies.


Change in Ig expression of a human lymphoblastoid line during long-term culture. A human lymphoblastoid line, in continuous culture for over 3 years, showed changes in Ig expression with time. The following pattern of events was suggested by studies of Ig synthesis and secretion performed at intervals. In a mass culture containing a heterogeneous cell population, Ig expression may shift because of selection acting on the different phenotypes. In human lymphoblastoid lines there may be a tendency for selection to favor IgMchi-producing cells. In clones, including those that synthesize multiple H chains, substantial determinism for Ig expression is present.


Pharmacokinetic study of ketoprofen (19.583 R.P.) in man using the tritiated compound. Ketoprofen (19.583 R. P., Profenid N. D., Orudis) labelled with tritium was administered orally to 4 patients (3 men - 1 woman) at a dose of 150 mg (therapeutic dose) with a radioactivity of approximately 500 muCi. Tritiated ketoprofen capsules, which disintegrated in the stomach, were administered in particle size of the same order as in the clinical trial material. The ketoprofen plasma levels and the quantities of the compound excreted in the urine and faeces were measured for 5 days after the administration of the capsules. Ketoprofen is absorbed rapidly and its plasma levels, which vary from patient to patient, can be comparatively high (9 to 21.3 mg/l), but these levels fall rapidly by 2 or 3 half-lives. Ketoprofen and its metabolites are excreted mainly in the urine (approximately 85% of the radioactivity administered is excreted within 5 days) and to a very limited extent in the faeces (within 5 days: approximately 1 to 8% of the radioactivity administered). Thus the evaluation of the radioactivity shows that the compound and its metabolites are almost completely excreted by the 5th day after administration. The ketoprofen urinary excretion rate is fairly closely correlated with the disappearance of the compound from the plasma. Overall measurements of the compound in the plasma and urine show that ketoprofen undergoes a relatively significant degree of metabolic transformation in man since, on an average, approximately 55% of the administered compound is recovered as metabolites from urine samples. In faeces, the relative significance of the transformation into lipo-soluble metabolites and water-soluble substances suggests that the metabolic transformation has a bacterial origin which varies in different individuals. The parameters of the pharmacokinetics of ketoprofen and its metabolism show no differences between the sexes in the cases studied.


The pharmacokinetics of ketoprofen in man during and after repeated oral dosing (50 mg q.i.d.) with Orudis. The pharmacokinetics of ketoprofen were studied in 5 healthy male volunteers after the oral administration of Orudis as a single dose (50 mg) and during, and after a 24-day repeated dosing regimen (50 mg q.i.d.). Levels of ketoprofen in plasma and urine and of conjugated ketoprofen in urine were measured after extraction, by a gas-liquid chromatographic method, which involved the use of a structurally similar internal standard. The minimum level of detection of the method was 40 ng ketoprofen/ml of plasma or 20 ng ketoprofen/ml of urine. The pharmacokinetic parameters obtained following a single oral dose, were comparable with those obtained in previous studies with human subjects from Britain, America and France. Repeated oral administration of a therapeutically effective dose of Orudis (50 mg q.i.d.), resulted in the rapid attainment of a plateau plasma level of ketoprofen, which was maintained throughout the course of dosing. Ketoprofen plasma levels and urinary clearance after the final dose of the 24-day repeated oral dosing regimen, were more variable and generally lower than those found following a single oral dose. However, the early plasma half-lives for the two experiments were similar. It was concluded that in the initial stages of repeated dosing a reduction in ketoprofen absorption, compared to that found after a single oral dose, occurred, and resulted in lower plasma levels of drug.


Ophthalmic screening of patients receiving ketoprofen or flurbiprofen medication for inflammatory and degenerative joint diseases. Twenty-seven patients with inflammatory and degenerative arthritis, who had been treated with either ketoprofen and flurbiprofen, for a period of up to twenty-four months, were examined for evidence of ocular toxicity. A practical method for examining the ocular structures and assessing visual function is described. A number of ophthalmic abnormalities were noted but these were related to previous or present eye disease or degeneration. It was considered that no ocular toxic sideeffects could be attributed to either drug during the period of treatment.


[Biophysical and ultrastructural aspects of an implant-bone interface]. The study of the interface between implant and bone suggests that the ideal material should not be chosen the most inert, but on the contrary among materials apt to provoke the formation of a connective layer between bone and implant. Certain ceramic materials have these required properties.


[Biomechanical apsects of implantation in bone]. Bone in the adult shows a continuous adaptation to the actual influence of applied stress by a combination of apposition and resorption. Little is known about this process around dental implants. It is only resorption which is known to be in relation with micromovements between bone and implant. Thus, the formation of connective tissue around implants is explained. The mechanical stress upon this connective tissue leads to the formation if fibres which recall the system of suspension of the teeth.


[What ensures the success of implants?]. A definition is given on the standard circumstances necessary to ensure success of dental implants over a longer period of time: -A proper indication is based upon all anatomical, radiological, medical and psychological factors. -The technique of implantation must be as atraumatic as possible. -The prosthetic work must be constructed after principles of occlusion relative to the temporomandibular articulation. -At the site of the implant abutments, the principles of periodontal prophylaxis apply. Sufficient attached gingiva and optimal oral hygiene are paramount to success. The results with 94 implants, of which 90.5% are worn without complications show that it is possible to achieve success when considering the above-mentioned rules.


[Dynamic compression implant--principles, technic and results]. The basis for the development for a dynamic compression implant (DCI) is the axiome of the mechanically induced bone reaction. Only if the implant is absolutely stable against the bone can an adaptive apposition and transformation be induced. T obtain such stability is the real problem. Transversal, sagittal and vertical forces act upon the implant and the structure of the maxillary and mandibular bone is sometimes unsuited to the purpose. The present concept for the required stability is based upon adaptive friction and a compressive factor as well as upon equalizing the differences of elasticity between bone tissue and metal. The technical procedure is described and illustrated. It should be an established requirement to obtain a minimum of 10 years duration in order to have an effective rate of success. The rate of intact implants after 5 years is encouraging the continuance of the experiments.


[Materials-testing research on hard and high strength dental plasters]. Types of III and IV dental plasters (ADA specifications No. 25) are used for making working models for clinical and laboratory purposes. 14 plaster products of these two types were examined for their physical properties and compared to the specifications, namely of setting time, volume changes, resistance to pressure and accuracy of detail. Additionally the values of surface hardness, bending strength and resistance to scraping were examined. Accordingly, three products were attributed to special stone (specification No IV): Duricap red (predosed capsule), Glastone, and Vel Mix Stone.


Cytomorphological determinants of prognosis in acute lymphoblastic leukemia of children. In children with ALL, the appearance of leukemic cells in stained spreads can be useful in predicting outcome of the disease. Cell size and nucleolar size and prominence are the two criteria, detectable on Romanowsky-stained bone marrow spreads, which permit such prediction. In a series of 93 children with ALL, 48 "poor risk" patients were detected. More than 1% of the bone marrow blast cells of these patients exceeded in diameter twice the diameter of nearby red blood cells, and, on average, more than one nucleolus was visible in every two leukemic cells. The survival of these 48 patients (estimated median 18 mo) was significantly worse (p = 0.0036) than that of the other 45 patients (estimated median over 5 yr). Analysis of the series with respect to other risk factors (age, leukocytosis at diagnosis) revealed the cytomorphological risk to be independent of the other two. Comparison of this method with others which have been used suggests that the proposed method may be more reproducible (capable of being learned) than others because it relies on specific characteristics rather than on total recognition of a "cell type," and that it may select a higher proportion of "poor risk" patients than other methods. PAS-positivity may be a useful additional criterion.


Cytogenetic heterogeneity of the acute leukemias. Cytogenetic abnormalities have been found in approximately 50% of all patients with acute leukemia. Although no chromosomal abnormalities have been found which are characteristic of a specific cell type, patients with AML and DiGuglielmo's syndrome more frequently have hypodiploid chromosome numbers, while patients with ALL seldom have hypodiploid numbers of chromosomes and may actually exhibit an extreme degree of hyperdiploidy in the leukemic cells. Chromosome analysis may be helpful in characterizing patients with preleukemia and DiGuglielmo's syndrome, and aneuploidy may correlate with shortened survival in these conditions. Although data so far available are conflicting concerning the relationship of aneuploidy to response to therapy in patients with acute leukemia, it is possible that as improved therapeutic regimens become available for the treatment of acute leukemia, more sophisticated cytogenetic analysis may be helpful in predicting survival and response to therapy.


The pathogenesis and clinical patterns of blastic crisis of chronic myeloid leukemia. Blast crisis terminates the life of the majority (approximately 80%) of patients with CML. The time of its onset appears to be a random phenomenon, varying from a probable coincidence occurrence with the onset of CML to more than a decade after onset of the chronic phase. In most patients the diagnosis is obvious as very immature cells are found to be the predominant cell in blood and marrow. However, in some, the onset is fairly subtle and the diagnosis of the syndrome will be dependent upon ancillary clinical and laboratory clues supplementing morphologic appearance of the blood and bone marrow. The same spectrum of morphological cell types is observed in blast crisis as is observed in acute myeloid leukemia. The predominant cells usually are myeloblasts and promyelocytes but may be immature monocytes, myelomonocytes, proerythroblasts, or immature megakaryocytes. These and other findings imply that the defect resides in the pluripotent hematopoietic stem cell. It is possible, but by no means proven, that lymphoblastic conversion also may occur. Therapy of blast crisis is quite unsatisfactory but clearly is of benefit in some patients.


Acute erythroid leukemia after cyclophosphamide therapy for multiple myeloma: report of two cases. The diagnosis of multiple myeloma was made in two white men, aged 55 and 59 years. They were treated with cyclophosphamide for 98 and 44 months respectively. Patient 1 also received a nine-month course of combined therapy with melphalan, procarbazine, and prednisone. Both developed acute erythroid leukemia, 98 and 71 months after the original diagnosis of myeloma, and died of subarachnoid hemorrhage and cardiac arrest. Patient 1 developed squamous cell carcinoma of the skin with recurrence, and Patient 2 developed anaplastic carcinoma of the urinary bladder. Palliative radiation therapy was given. The development of erythroid leukemia plus carcinoma in these two men suggests mutagenic change secondary to cyclophosphamide therapy.


Malignancies in blood-forming organs following diagnostic and therapeutic procedures: a review. Ionizing radiation used for diagnosis or therapy has been associated with an increased incidence of malignancies of blood-forming organs. The increased incidence of hematopoietic malignancies following exposure to ionizing radiation obtained in the course of occupation, diagnosis and therapy of disease, or as a weapon of war is documented. The natural occurrence and the induced progression to acute leukemia of polycythemia rubra vera, Hodgkin's disease, multiple myeloma, Di Guglielmo's disease, and reticuloendothelial malignancies are discussed. The status of transplantation and immunodeficiency states and their relationship to acute leukemia is reviewed. Finally, drugs, toxins, and the use of cytotoxic radiomimetic agents for nonmalignant purposes are shown to lead to the development of acute leukemia. Background information relevant to the  proper use of future diagnostic and therapeutic modalities is provided.


Anorexia and weight loss in the portacaval-shunted pig. The pig shows a marked response to end-to-side portacaval shunt. Survival is short and levels of alkaline phosphatase and cholesterol fall. This study was designed to determine the role of the reduced food intake which follows the operation upon these results. In pair-fed, sham-operated pigs, survival was short and levels of alkaline phosphatase and cholesterol also fell. Sham-operated animals fed normally did not show this response. Reduced appetite has been recorded in many experimental animals after portacaval shunt, but the cause remains to be elucidated. Encephalopathy, bacteremia, peptic ulceration, or hormonal imbalance could be implicated. Similar alteration in appetite and weight loss have not been observed in children who have been treated by portacaval shunt for glycogen storage disease or hypercholesterolemia; however, the underlying metabolic disorder or the species difference may be a contributory cause.


Hemodynamic changes in rats after radioprotective combination of cystamine administered subcutaneously and 5-methoxytryptamine injected intramuscularly. Administration of cystamine (20 mg base/kg s.c.) and 5-methoxytryptamine (10 mg base/kg i.m.) with 12 minutes delay to anesthetized rats induced the depression of whole cardiovascular system, hemoconcentration and great blood flow decrease in the radiosensitive tissues. Distributionof lowered cardiac output preferred the fractions to brain, heart, liver and lungs. Hemodynamic responses to protective combination may participate in its radioprotective action.


[Infrared-spectroscopic studies of the carbonate apatite structure of dental hard tissues]. Samples of enamel, dentine and cementum were calcined at temperatures of 500 degrees C, 800 degrees C and 1000 degrees C. The infrared spectra recorded at these temperatures were evaluated quantitatively and qualitatively. With increasing temperature, the conversion of the primarily present carbonate apatite into hydroxyapatite increased. At 800 degrees C, a hydroxyapatite proportion of 83% was found. At that, the thermal treatment produced in the dentine an increase in the degree of crystallization from 62% to 100%.


[Evaluation of filling therapy of the lateral teeth and recommendations for the practice]. This paper deals with the caries intensity in the region of the lateral teeth and the present state-of-the-art of the filling therapy as evidenced by late results of silver-tin amalgam fillings and inlays. Various possibilities of quality improvement are discussed, and recommendations are given for practice.


[Longitudinal studies on the inhibition of caries by amine fluoride within the framework of guided and supervised oral hygiene actions]. In a 3-year, 4-year and 5-year studies, the authors tested clinically and radiographically the caries-inhibiting efficiency of topically applied amine fluoride in defined groups (fluoride group with Elmex fluid and Elmex tooth-paste for unsupervised dental and oral hygiene at home, placebo group and control group). After the fifth study year, the caries increment in the children who were 11 years of age at this time had decreased by 30.6% (DMF/T index) and 32.1% (DMF/S index).


[Simultaneous treatment of anomalies during manafement of fractures in the maxillofacial region]. Any schematism in choosing an operating technique is inappropriate in the surgical treatment of anomalies alone. This is all the more true in case of concomitant facial bone fractures which require all sorts of combinations and variations of the known procedures. None of the 13 patients who had presented during the years 1969-1973 with a maxillofacial fracture and an anomaly was subjected to the same kind of operation (with regard to osteotomy and ostectomy). An asymmetrical approach had to be adopted in almost any case to accomodate to the precautions required in the surgical treatment of the anomaly as well as to the demands on fracture management.


[Survey of dental drug prescriptions].

[Survey of dental drug prescriptions]. 6665 prescriptions written out by stomatologists of a large town within three months were analysed with the aid of commercially available slotted cards for which a special hole-saving code had been established. There were differences between the prescriptions from the different fields of stomatological activity (policlinic, privately conducted practice, university clinic) as to contents, which is probably due to their differing tasks. Selected problems, e.g., the prescriptions for personal use (the proportion of which was 12%) and the prescriptions of analgesics were discussed in detail. The results obtained were compared with previous literature reports.


[Analysis of loss of working hours in a dental department]. The economical use of the societal working capacity, which is substantially influenced by the loss of working hours, requires a time study. The loss of working hours was analysed for three professional groups in a stomatological service in 1973.


[Experimental studies on the effects of various dosages and working temperatures on the flow behavior and the elastic characteristics of a normally flowing silicone casting investment]. The main purpose of the present paper was to study the elastic properties of silicone impression material containing an overdose or underdose of hardener as a function of the time elapsed from the start of the mix. Additional measurements of the quasi-viscosity as a function of dosage and mixing temperature were performed to cover the plasto-elastic transitional phase after mixing. The experimental conditions have been established according to the results from previous processing tests. Overdosage as well as underdosage of the hardener caused (according to its extent) marked or in part considerable deterioration of the elastic properties. The differences from normodosed material decreased with the time elapsed from the start of the mix. Having discussed his observations from the viewpoint of materials science, the author draws conclusions as to the processing of silicone impression material and to the differential indication of alginate and silicon materials for one-stage impression.


[Improvement in the radiographic interpretation in acute osteomyelitis of the jaw by means of the densitron]. As the acute stages of jaw osteomyelitis are not visible on the normal radiograph, the author used the Densitron to convert into colour elements the gray-values of the the radiograph. The Densitron picture discloses the beginning of the loosening of the bone structure already in stages when not any peculiarity is revealed by the normal radiograph. The Densitron is a valuable tool for establishing objectively the early diagnosis of acute stage of osteomyelitis (so far mainly based on anamnestic indications and clinical manifestations), which is of importance to purpose-oriented early treatment.


[Topical treatment of maxillary sinusitis. Preliminary report]. The representation of fundamental ideas is followed by the description of a new instillation preparation for the local treatment of sinusitis. The sterile filling material contains chloramphenicol, sulphanilamide and prednisolone in an organic, absorbable carrier substance based on gelatin. The indication, the technique of application and the results obtained up to now are mentioned. An average of 2.4 instillations was sufficient to achieve healing in 78.5% of the patients. Spontaneous closure of a great perforation occurred in some cases. It is emphasized that the surgical intervention nevertheless remains an integral part of sinusitis therapy and that the results obtained up to now should be corroborated by a greater number of cases and additional investigations.


[The use of cartilage and tissue adhesives for the treatment of surgical-stomatological diseases in old age]. The authors used lyophilized cartilage in plate, bar, chip or powder form in elderly patients. The transplant was also utilized in managing defects resulting from the removal of jaw cysts, bone tumours, etc. Furthermore, the authors treated bone defects of the anterior wall of the maxillary sinus and of the hard palate as well as oro-antral perforations, infected wounds of the soft tissues and inflammatory bone processes. The patients in question had been treated in the surgical service during the years 1959--1975. The authors observed in elderly patients pathological alterations of the capillaries, haemorrhagic tendency and impairment of the blood-clotting mechanism. Furthermore, they found that the granulation tissue was of poor quality. In these cases they used cartilaginous tissue in powder form which promotes the formation of granulation tissue well supplied with blood. In the patients mentioned, the authors also utilized surgical adhesive, namely after tooth extractions and in managing their complications.


[Use of ear adapters in cases of cartilage malformations of the outer ear]. The author describes a malformation of the cartilage of the external auditory meatus. This malformation might be repaired by a surgical intervention. The patient in question needed prosthetic treatment. The resultant problems are dealt with, and a solution is suggested.


[Experiences with the use of the double crown system. 2. The overlay prosthesis]. The results obtained by the authors permit the conclusion that cover dentures within the telescoping system cannot be considered profitable owing to loosening of the abutment teeth, irreparable injuries to the marginal periodontium and relatively considerable repair requirements. The injuries observed are so aggravating that the aesthetically pleasant designing of these prostheses, their relatively low laboratory fees and the possible saving of metal do not justify their use.


[Disinfection and sterilization in stomatologic practice from the viewpoint of the district health inspection]. Disinfection and sterilization measures are of paramount importance in the prevention of iatrogenic infections in the medical consulting-room. They are parts of the hygiene schedule in the office. The disinfection and sterilization measures are largely determined by law. Their securing is incumbent on the head of the respective institution. The control of this securing devolves on the State Hygiene Inspectorate. With regard to the stomatological work place, special conditions arise in enforcing observance of the legal provisions. The author tries to compile some of these conditions from the viewpoint of a district hygiene inspectorate.


Hemolytic transfusion reactions caused by failure of commercial antiglobulin reagents to detect complement. Two definite acute hemolytic transfusion reactions occurred in a patient with chronic myelogenous leukemia in blastic crisis. Both suspect units were entirely compatible by routine crossmatch using commercial antiblobulin sera. However, both units were clearly incompatible using our own specific anti-C3 antiserum in the antiglobulin reaction phase of the crossmatch. Subsequently it was possible to predict in vivo compatibility using our anti-C3 antiserum in vitro. This case adds new evidence for the inadequacy of anticomplement activity in commercial antisera.


[Experimental investigations of muscle transplants in correction of congenital diaphragmatic defects (author's transl)]. Rives muscle plasty using a pediculate flap of the latissimus dorsi muscle is an approved method for correction of large congenital diaphragmatic defects. To study morphology and function of the transplanted muscle flap 10 beagle dogs were operated upon bilaterally in two stages. Thus a total of 20 muscle transplants was evaluated. A standard Rives plasty was performed, emg electrodes were inserted into the diaphragm as well as into the muscle transplant. The surgical procedure was tolerated very well, there was no operative mortality. The period of observation varied between 18 and 48 weeks, the average being 30 weeks. Postoperatively there was no electric activity found in the muscle transplants, whereas the diaphragm showed its characteristic interference pattern during inspiration. In 5 cases, however, action potentials appeared in the muscle flap after 12 to 16 weeks. They had the semblance of fibrillation potentials and short sharp waves and were considered to be preceding reinnervation potentials, which occured 24 to 32 weeks postoperatively in these cases. In 2 cases the emg findings were inconstant, in the residual 13 cases there was no electrical activity in the muscle transplant during all the observation time. The emg findings corresponded to the histological postmortem findings. These showed in altogether 6 cases numerous intact muscle fibres as well as nerve trunks with neurites, especially in the neighbourhood of the diaphragm. In the middle of the flap and even more near the thoracic wall the number of intact muscle fibres decreased. Thus a partial reinnervation due to muscular neurotization starting from the diaphragmatic margin was assumed in these cases. In the rest of the flaps the muscles were largely atrophic and showed considerable lipomatosis, only minor fibrosis and never a distinct scar formation. Therefore, the flaps represented living tissue with intact vascularization and functionally good adaptability. Reinnervation, observed in some cases, is not the main factor for the good clinical results obtained with Rives muscle plasty, but can improve adaptability and elasticity of the transplant considerably. According to the lack of scar formation and the preponderance of fatty tissue an increase of the transplant considerably. According to the lack of scar formation and the preponderance of fatty tissue an increase of the transplants size during growth seems possible. Thus Rives muscle plasty using a flap of the latissimus dorsi muscle to cover large congenital diaphragmatic defects seems morphologically as well as functionally superior to other procedures especially those using plastic material.


[Sound spectrographic investigations of heart sounds and murmurs and of the sounds produced by artificial valves (author's transl)]. The normal heart sounds, murmurs, opening and closing sounds of aortic and mitral valve prostheses were recorded on a tape in order to obtain the highest frequencies which were recordable on the chest wall. Sections of these tapes were analyzed in terms of contour sonagrams. For this purpose six groups were formed and investigated: group I comprised persons without cardiovascular diseases, group II patients with mitral valve failure, group III patients with aortic valve failure, group IV patients with congenital heart disease, group V patients with Starr-Edwards aortic valve prostheses (model 1260) and group VI patients with various mitral valve prostheses. In each of these groups the highest recordable frequencies were measured. The peak frequencies varied widely in regard to frequency range in a comparison of the six groups. The maximum was reached at about 8000 c.p.s. in the case of the sounds of prosthetic valves. Furthermore, sound level examinations of the normal first and second heart sounds, as well as of the opening and closing sounds of the aortic valve prostheses were performed. The highest sound level of all of these sounds was found to lie within the low frequency range of 40 to 100 c.p.s. The results of both the measurements of the peak frequencies and of the maximal sound level were discussed on the basis of the presently accepted theories on the mechanism of heart sounds and murmurs.


Hiatal hernia. Follow-up of a ten-year material. A clinical study of 70 patients with hernia hiatus oesophagi (59 sliding hernias, 11 paraoesophageal), of whom 22 had received primary surgery, 33 medical treatment and 15 with no discomfort from the hernia had no primary treatment at all. None of the patients in any of these groups had undergone an operation later. A follow-up examination in 1972-73 was achieved in 43 of the 70 patients (16 of those with surgery, 18 with medical treatment and 9 with no treatment); 6 of the others did not attend the follow-up and 21 had died. Of the 16 operated patients, 8 stated they were free from discomfort and 8 that they had improved (7 of the latter only after additional medical treatment). Of the 18 patients who had received only medical treatment, 8 stated that they were free from discomfort (2 of them not until the medication had been changed), 6 that they had improved, 2 had noted no improvement, and 2 a deterioration even though their medication had been changed. Of the 9 untreated patients, 4 stated that they still had no discomfort and 5 that discomfort had materialised later; subsequent medical treatment had eliminated the discomfort in 2 of the later and produced an improvement in 2 more; the 5th patient had not reacted to medical treatment - the follow-up disclosed an inoperable gastric carcinoma.


Bronchial brushing during fiberoptic bronchoscopy for the cytodiagnosis of lung cancer: comparison with sputum and bronchial washings. In a study of 50 cases of bronchogenic carcinoma in which brushings and washings during fiberoptic bronchoscopy, as well as sputum cytopathologic examinations were performed in the same patients, accuracy rates were respectively: 76 per cent, 76 per cent and 56 per cent. The main cytologic differences setting brush apart from wash and sputum specimens referred to the arrangement of tumor cells as well as the distribution of chromatin within their nuclei. These differences appeared related to cell degeneration which was minimal in brush materials and maximum in sputum specimens. Only six cases were assigned a different cell type of bronchogenic carcinoma when brush cytopathologic diagnoses were compared with results obtained by biopsy or lobectomy specimens. Our findings are consistent with the view that the brush technique is very accurate for the cytodiagnosis of lung cancer and becomes also rather specific once cytologic characteristics of the fresher samples obtained become familiar to the cytopathologist. Non-observance of the special characteristics of these better preserved cellular samples is the major pitfall as to diagnosing, cell typing and judging degree of differentiation of bronchogenic carcinoma in brush cytology specimens.


Pale nodular nuclei-diagnostic of adenocarcinoma of the pancreas? Malignant cells with an unusual and striking appearance are described in a series of cases with carcinoma of the pancreas. It is suggested that the pale nodular nuclei seen in these cases may be of diagnostic value.


Statistical criteria for the cytology of gastric cancer a proposal of distance index. The concept and term of Distance Index, a complex ratio of cell, nucleus and nucleolus has been previously reported by the author. Twenty were sampled from thirty-four advanced cancers, twenty-one early cancers and six benign atypical lesions for this stochastical diagnostics. Distance Index was proved to have better diagnostic value in separatings the gastric cancer and the benign epithelium than the nuclear cell ratio and the nucleolar cell ratio. It has been found that the value of the constant K is most suitable at 130.


The prognostic value of the aspiration biopsy smear in mammary carcinoma. The prognostic significance of various morphologic factors (size of nuclei, nucleoli, mitotic frequency, naked carcinoma nuclei, nuclear:cytoplasmic ratio, size of cell clusters, necrotic matter, mucoid matter, and lymphocytes) was studied in aspiration biopsy smears from 494 carcinomas of the breast. A multivariate analysis of clinical and cytologic variables was performed with regard to five-and ten-year survival.


[Dynamical study of cerebrospinal fluid at the spinal level during isotopic cisternography. 74 cases]. Physiology teaches that in addition ot be basic areas of C.S.F. resorption in the region of the cerebrum, supplementary zones exist situated in particular at the coverings of the spinal nerves. The aim of this study was a quantitative and dynamic analysis of spinal flow in 74 subjects, 64 of whom had clinical signs of communicating hydrocephalus. In certain of them, classical examinations provided no precise indications as to the appropriate neurosurgical procedure. Study of the dynamics and resorption of the C.S.F. in the spine would appear to provide new elements in assessment prior to the decision to insert a ventriculo-atrial valve.


[Peritoneal irrigation-dialysis as a complement to the treatment of systemic acute peritonitis]. A series of 30 cases of post-operative peritoneal irrigation dialysis for generalised peritonitis. In the light of peritoneal physiology, details are given of the technique for insertion of the peritoneal drains as well as the composition of the dialysate. In addition to its mechanical role, continuous lavage of this type is useful in restoring and maintaining water and electrolyte balance, the limitations of which are described, together with a direct anti-infectious action and temperature equilibration. P.I.D. seems to be associated with a considerable reduction in mortality from acute generalised peritonitis (1 case out of 30). It also limits morbidity, since only 5 minor complications were seen. The simplicity and harmlessness of the method makes it possible to widen, without major reservations, the scope of therapeutic solution to the problem of acute generalised peritonitis.


[Association of monoclonal gammopathy with chronic glomerulonephritis and autoimmune hyperlipemia. Course of disease during therapy]. A case of benign monoclonal gammapathy associated with an auto-immune hyperlipidaemia and a chronic glomerulopathy is reported. Extraction of the monoclonal immunoglobulin made it possible to demonstrate its anti-lipoprotein antibody activity. Parallel changes in serum lipid levels and monoclonal immunoglobulin levels under the influence of melphalan confirmed the direction relationship between the lipid and protein disorders. The pathogenesis of the glomerulopathy and of the massive and prolonged activation of the classical complement pathway is more difficult to affirm. It is nevertheless possible that the renal involvement is due to an auto-immune complex disease.


Effect of repeated bloodletting on the incidence of 2,7-FAA-induced rat leukemia. The oral administration of N,N'-2,7-fuorenylenebisacetamide (2,7-FAA) induced leukemia, especially mature granulocytic leukemia, in rats. 2,7-FAA was administered to the rats of the Wistar strain and a small amount of bloodletting was repeated for a long period. The incidence of leukemia and mature granulocytic leukemia became elevated by bloodletting. The induction of mature granulocytic leukemia might be increased by the promotion of granulopoiesis which had been suppressed by 2,7-FAA.


Evidence for glucocorticoid receptor in human leukocytes. The glucocorticoid uptake in vitro by human periferal leukocytes was studied. The uptake showed 2 main components, one saturable and one non-saturable. The saturable component was compared with the uptake by the specific glucocorticoid receptor in rabbit granulocytes. The similarities with the rabbit receptor in structural specificity, time course of uptake at 37 degrees C, sensitivity to metabolic inhibition by PCMS and the physiological concentration for half saturation indicate that the saturable component corresponds to a specific glucocorticoid receptor. Cells from chronic lymphatic leukemia and chronic myeloic leukemia were also studied. Only the former had a saturable glucocorticoid uptake.


A biodifferential system of face-bow mechanics. A review of the literature, both scientific and commercial, did not demonstrate the separation of the inner and outer bows into a biodifferential interchangeable system. The prime design idea, to separate the inner and outer bows, increased versatility and yielded a multiple appliance with a greater range of use and safety. The joint couple systems could be adapted to fulfill the criteria cited in the literature during preliminary treatment (deciduous dentition), partial treatment, full-banded treatment, and retention. The biodifferential design was compatible with most mechanical orthodontic appliances and systems currently used. The three joint designs presented and the three inner bow lock devices fulfilled the parameters expected from the normal use of the present face-bow in necessary strength, stability, and use. Further, the use of a joint couple between the inner and outer bows expanded the versatility of the face-bow into a biodifferential system and allowed for an easily manageable and orderly change of forces, vectors, sizes, and shapes requiring little chair time and minimum instruction to the patient. The inner bow could be used as an intraoral appliance for bumpers, shields, and oral screens. These easily made, preformed, interlocking parts could be marked or color coded as to type and size and keyed, grooved, and designed to prevent inverted interlocking of parts. The inner bow could be tied in, as an aid in patient cooperation, or the inner and outer bows could be pinned or ligated together to prevent separation. One of the most important factors of the biodifferential system is protection of the patient from severe trauma to the eyes, face, and mouth due to misuse or accident, as has occurred in the one-piece face-bow. The biodifferential system fulfills the five criteria of the investigation: (1) a system of interchangeable, interlocking joint parts, (2) safety and dependability, (3) easy changes in force, vectors, and moments, (4) enhanced patient cooperation, and (5) oral hygiene.


Centers of rotation for combined vertical and transverse tooth movements. For purely transverse orthodontic tooth movements, the center of rotation is defined as that point on the long axis or its extension which remains stationary during the movement and around which the rotational component of the tooth displacement takes place. For tooth movements having both vertical and transverse components, no point on the long-axis line remains fixed in space. The two-dimensional theory proposed herein suggests the more general definition of the center of rotation as that point on the long-axis line which displaced the shortest distance during the tooth movement. The center of rotation can be located for the combined transverse and vertical tooth displacement. It is found to move along a path coincident with a segment of a line in a position depicting the tooth angulation midway through the movement. Formulas, which can be used in conjunction with a composite pre- and post-displacement cephalometric tracing, are presented herein to define the center-of-rotation location for such tooth movements.


A comparative study of condenser humidifiers. Three currently available condenser humidifiers were studied to assess their ability to conserve water loss and to measure the resistance imposed by the apparatus. The value and possible effectiveness of these devices in clinical practice is discussed.


Veno-occlusive disease of the liver after chemotherapy of acute leukemia. Report of two cases. Two adult male patients with acute leukemia developed a fatal Budd-Chiari-like illness while receiving 6-thioguanine. Both had previously received cytosine arabinoside. Antemortem and postmortem specimens of liver showed changes characteristic of toxic veno-occlusive disease. Similar findings have been described after ingestion of certain plant alkaloids and after treatment with arsphenamine, urethane, and ionizing radiation to the liver. We are unaware of any published reports of veno-occlusive disease of the liver after treatment with either 6-thioguanine or cytosine arabinoside. Although 6-thioguanine was most likely responsible for this syndrome, it is not possible to eliminate cytosine arabinoside as the causative agent. Since both drugs are occasionally used for benign conditions, physicians should be aware of this possible complication.


Staphylococcal bacteremia in a "Germ-free" unit. The rate of carriage and infections due to strains of Staphylococcus aureus were evaluated in adults with acute leukemia in isolators characterized by laminar air flow and barrier isolation. Patients were randomly given antimicrobial prophylaxis with oral nonabsorbed antibiotics and a nasal antibiotic ointment. In four years S aureus was isolated from the nostrils or other sites in 36 patients. Persistent isolation was noted in 24 patients. Suppression of gut flora was associated with a higher carriage rate of S aureus. Five episodes of bacteremia due to S aureus occurred at the nadir of leukopenia induced by chemotherapy. Death occurred within five days in the three patients whose peripheral white blood cell count did not rise. Patient isolation and suppression of gut flora helped reduce infections due to Pseudomonas sp and fungi, but S aureus emerged as a life-threatening pathogen.


Cigarette smoking and the microbial flora of the mouth. A range of selective media was used to culture the microbial flora of the dental plaque, tongue and palate, The subjects were five young men who smoked more than twenty cigarettes a day and four who did not smoke. Neisseriae were less numerous on the mucosal surfaces of the smokers.


Free full thickness mucosal grafts in the mouth. Examples of full thickness mucosal grafts used in sulcoplasty and the closure of defects in the tongue and cheek following tumour ablation are shown and the techniques in their use are demonstrated. The problems and advantages in this are considered.


Parotid saliva acid phosphatase in health and disease. Acid phosphatase levels in serum from 5 patients with prostatic carcinoma were diagnostically higher than those from 5 patients who had undergone prostatectomy. The levels for saliva when compared with those from normal subjects for stimulated (314) and unstimulated (50) salivas could not serve as an index of serum concentration.


Correlation between streptococci of human dental plaques and dental caries. Plaque samples from 27 buccal tooth surfaces were obtained with sterile McCall curettes from available third molars. Bacteriological sampling and biochemical tests were carried out to identify four groups of streptococci, i.e. Str. mutans, Str. spp., Str. sanguis and Str. mitis. Clinical examinations carried out 6 months after the dental scrapings were taken showed a strong positive correlation between detectable lesions and Str. mutans.


The effect of treatment provided by dentists and therapists in the South Australian school dental service. The second report. A survey of over 2,000 second year high school students at 13 South Australian schools indicated that those who had received school dental care at primary school had fewer carious teeth and, in some respects, better oral hygiene habits. Whilst they were better informed on dental subjects than were control students, fewer had attended a private dentist since leaving primary school.


The rate of development of strength in base forming materials for dental amalgam. Eleven base forming materials used under amalgam restorations were examined for the rate of development of their compressive and tensile strengths. Materials from three categories were compared. Under in vitro conditions of testing, it was found that, immediately after a state of clinical set had been reached, the quick-setting zinc oxide-eugenol materials possessed strengths significantly greater than the calcium hydroxide cements but significantly weaker than the zinc phosphate cements. Calcium hydroxide cements possessed the lowest compressive strength to tensile strength ratio and modified zinc oxide-eugenol materials the highest.


Improvement in the properties of gypsum casts by polymer impregnation. It is known that porous solids such as Portland cement, concrete, and ceramic tile bodies can be strengthened by polymer impregnation. The solid material is infiltrated with a liquid monomer, which is then polymerized in situ. In the present investigation, it has been found that this process is effective for strengthening gypsum casts prepared from ordinary laboratory plaster. Impregnation with poly(methyl methacrylate) confers marked improvements in tensile and compressive strength and abrasion resistance. The process would be particularly applicable to the preservation of study casts for record purposes.


Dentine hypersensitivity.

Dentine hypersensitivity. Reports received from 32 dentists on the effect of a complex mixture of calcium sucrose phosphate and calcium orthophosphate used as a gel, toothpaste, or slurry in relieving pain in hypersensitive dentine show, in 137 patients, complete relief in 112. It was found that in 54 patients the prior use of stannous fluoride prophylactic paste was beneficial.


The effects of manipulative variables on base forming materials for amalgam restorations. The influence of several manipulative variables on the compressive and tensile strengths of eight base forming materials has been investigated. The most important manipulative variable from the point of view of influencing the development of strength was found to be the powder-liquid ratio. In particular, thicker mixes produced greater early strengths. The setting time of each material was found to be influenced more by the temperature during setting than the ambient temperature or presence of moisture.


Laboratory effectiveness of different types of fluoride compounds. The enamel solubility reducing characteristics of four fluorides -- sodium fluoride (NaF), acidulated phosphate fluoride (APF), stannous fluoride (SnF2), and sodium monofluorophosphate (Na2PO3F), each prepared to contain 1.23 per cent F are evaluated. Initial solubility reduction by SnF2, 81.7 per cent was significantly (P less than .01) higher than that of 76.9 per cent provided by APF, however, after repeated exposure to acid etches the protection by APF became significantly (P less than .01) higher than that derived from SnF2. The durability of protection provided by SnF2 after overnight washing, was significantly (P less than .01) higher than that of APF. Results for NaF and MFP were significantly (P less than .01) lower than those of either APF or SnF2 at any point in the experiment.


Pathophysiology of occlusal balance.

Pathophysiology of occlusal balance. Functional disturbances of the masticatory system reflect a failure in the adaptive capacity of the individual to excessive structural and functional demands. Formerly, a particular type of articulation, balanced occlusion, was thought necessary for maintaining the health of the dental apparatus. Over the years the concept of stability of occlusion has evolved, however controversy still exists as to where stable tooth contact is made, centric occlusion of centric jaw relation. In order to express biological adaptability within the normal masticatory system, harmony at the anatomical median occlusal position is suggested as the prerequisite of a physiologically balanced occlusion.


A comparitive study of the healing of wounds made by scalpel and electrosurgery in rabbits. A study in the rabbit of the healing of wounds made by electrosurgery and scalpel showed less damage to the tissues arose with the scalpel and healing was more advanced at 24 and 48 hours. More extensive bleeding occurred when electrosurgery was used on the tongue. At 72 hours extensive fibrous tissue was seen but infiltration with inflammatory cells was heavier where electrosurgery was used. Epithelium had covered all wounds at seven days but basal cell layers were not complete and papillae had not reappeared on the tongue.


The clinical effectiveness of a disposable aspirating syringe. In 18 per cent of mandibular block injections and 2 per cent of maxillary infiltrations blood appeared in the carpule aspiration. In 500 mandibular block injections when an aspirating syringe was used in 250, only 0.7 per cent patients suffered toxic side effects compared with 5 per cent when a conventional non-aspirating syringe was used.


Variability of the nasion-subnasal, subnasalgnathion, and bizygomatic distances of individuals of 6, 7, 11, and 15 years of age and their importance in the determination of the vertical dimension. A study of the cephalometric points which represent the height and width of the face was undertaken in the city of Piracicaba on 576 boys and girls aged 6, 7, 11, and 15 years. Analysis of the data shows that the measurements increased progressively and proportionately with age and the importance of the cephalometric points in the determination of the vertical dimension in occlusion.


Human leukaemic cells. Determination of trace elements in nucleic acids and histones by neutron-activation analyses. Trace metals were measured by neutron-activation analyses in purified nucleic acids and histone(s) of lymphocytes from patients with acute lymphocytic leukaemia or infectious mononucleosis and from normal donor DNA isolated from lymphocytes of a patient with infectious mononucleosis and a normal donor showed a high a high content of Cr2+, Sb2+, Fe2+, and Zn2+, whereas DNA of lymphoblasts from a patient with acute lymphocytic leukaemia had a lower content of these trace metals, but the Co2+ content was 20-fold higher than in DNA or normal donor lymphocytic cells. Total histones from leukaemic cells had higher contents of most of the trace metals except for Zn2+, which was present in lesser concentration than in histones from normal donor lymphocytic cells. Lysine-rich (F1) histones showed lower contents of Cr2+, Sb2+ and Co2+, whereas arginine-rich (F3) histones had significantly higher contents of these trace metals. These observations may be of interest in that F3 histones more effectively inhibit RNA synthesis in human lymphocytic cells than do other species of histones.


Studies with the folate binding protein in chronic granulocytic leukaemia cells. I. Synthesis and release of binder by cells in short-term culture. Chronic granulocytic leukaemia (CGL) cells which contained a high concentration of unsaturated folate binding protein were incubated in suspension culture for a period of 5 h. Cell samples were periodically assayed for binder and these demonstrated active synthesis which was inhibited by puromycin, cyclo heximide, N-ethylmaleimide, and by incubation at 4 degrees C, but not by actinomycin D. Folate binding activity could also be demonstrated in the culture medium and this increased with the duration of incubation. This release of binder was inhibited by culturing the cells at 4 degrees C and by the addition of N-ethylmaleimide, but not by actinomycin D, puromycin, or cycloheximide. When the pre- and post-culture cell lysates were saturated with tritiated folic acid ([3H]PteGlu) and subjected to chromatography on DEAE-agrarose, approximately half of the bound folate eluted with 0.001 M phosphate buffer at pH 6.0 and the other half  eluted with 0.2 M buffer at pH 7.2. The culture medium and plasma from this patient with CGL was well as serum from two normal subjects saturated with [3H]PteGlu and similarly chromatographed contained primarily the acidic binder and much less of the binder eluting with the low molarity buffer. Since a folate binding protein immunochemically similar to the binder in CGL cells has been identified in the serum of non-leukaemic subjects, these experiments suggest that the source of circulating folate binding protein may be the immature granulocyte.


Treatment of residual neoplastic disease in solid tumours. Contemporary clinical research is actively engaged at the conquest of residual neoplastic disease. The preliminary results of combined treatment modalities for osteogenic sarcoma, Ewing's sarcoma, rhabdomyosarcoma, breast cancer, malignant melanoma and Hodgkin's disease have shown a significant decrease in the incidence of distant metastases. In some neoplasias the decreased relapse rate was associated to improved survival. Since the problem of long-term carcinogenesis does exist, the use of prolonged adjuvant chemotherapy, at present moment, is best limited to patients at high risk of early relapse when treated only with local or local-regional modalities.


Measurement and reduction of occupational exposure to inhaled anaesthetics. The occupational exposure of hospital staff to inhaled anaesthetics was investigated using a personal sampling device that provides a measure of the average concentrations breathed by a person over a period of time, as distinct from the spot sampling in the general environment. The anaesthetist's average exposure to nitrous oxide and halothane during complete operating sessions was twice that expected from simple dilution of the escaping gases by the operating room ventilation. The sampling technique was also used to evaluate the effect of (1) redirection of the waste gas outflow; (2) active scavenging connected to the piped vacuum system. Short-period studies under controlled conditions in the operating theatres and anaesthesia induction rooms showed that the anaesthetist's exposure could be reduced two- or fourfold by redirecting the outflow and another four- to sixfold by active scavenging. Exposures during complete operating sessions were reduced two- to seven-fold by scavenging.


Clinico-pathologic correlation of liver damage in patients treated with 6-mercaptopurine and Adriamycin. Eleven adults with refractory leukemia treated with a combination of 6-mercaptopurine and Adriamycin developed hepatic dysfunction manifested by elevations of serum total bilirubin, alkaline phosphatase, and glutamic oxaloacetic transaminase. Liver tissue obtained at necropsy showed intrahepatic cholestasis (eight cases), hepatocellular necrosis (ten cases), leukemic infiltration (two cases), and fatty change (nine cases). Neither this frequency nor severity of hepatocellular destruction has hitherto been associated with 6-mercaptopurine at the dose levels used in this study, nor has Adriamycin previously been found to be hepatotoxic. It is postulated that Adriamycin potentiated the hepatotoxicity of 6-mercaptopurine in these patients.


Cyclophosphamide therapy and interstitial pulmonary fibrosis. Intersitial pneumonia and pulmonary fibrosis developed in a 72-year-old man during therapy with cyclophosphamide, vincristine, and prednisone. After extensive investigations, including an open lung biopsy, cyclophosphamide appeared to be the cause of the pulmonary disease. Complete disappearance of tachypnea and the pulmonary infiltrates occurred after the discontinuation of cyclophosphamide and the institution of prednisone therapy. We concluded that the diffuse pulmonary disease in this patient was a result of cyclophosphamide therapy. The clinical and pathologic findings in this case and a review of the literature of cyclophosphamide pulmonary toxicity are reported.


Chemoimmunotherapy for maintenance in acute myeloblastic leukemia. Of 30 adult patients with acute myeloblastic leukemia, 14 achieved complete remission. Eight of these were given chemoimmunotherapy for maintenance. The immunotherapy consisted of intradermal pooled allogeneic leukemic cells (snap-frozen irradiated) and BCG vaccine given by Heaf gun, given twice in 4 weeks. The chemotherapy was given for 1 week in 4 weeks. The median duration of remission in these eight patients was 115+ weeks and the median duration of survival was 147+ weeks. The other six patients who were given chemotherapy only for maintenance had a median duration of remission of 15 weeks and a median survival of 52 weeks. The two groups cannot be compared properly, however, as allocation of patients was not random, and the chemotherapy differed significantly.


Philadelphia chromosome in acute leukemia: case report. A case report of serial chromosome studies on a child presumed to have acute lymphoblastic leukemia (ALL) is presented. Hematologic remission was achieved after 3 weeks and maintained until death 63 weeks later. The classic Philadelphia chromosome translocation was found, both at diagnosis and throughout the course of the disease, in a proportion of cells from PHA-stimulated blood cultures. The finding is related to other reports of Philadelphia-positive clones in ALL, as well as those in chronic myeloid leukemia and its acute transformation, and other myeloproliferative disorders. The origin of the Philadelphia chromosome in this case is considered in the light of current stem cell theory, and its relevance to lymphocytic neoplasia is discussed. We believe that the finding of a Ph1-positive clone in a cell line morphologically indistinguishable from normal lymphocytes in a case of acute leukemia is unique.


Leukemic ophthalmopathy in children.

Leukemic ophthalmopathy in children. Abnormalities of the eye were detected in 52 of 657 children (9%) suffering from acute leukemia. The treatment for leukemia was single agent chemotherapy administered sequentially. "Prophylactic" treatment of the central nervous system was not administered. Major manifestations of leukemic ophthalmopathy comprised retinal hemorrhage (in 19) and infiltration of the optic nerve, retina, iris or orbit (29). The ophthalmopathy was treated by topical dexamethasone and radiation therapy. Concurrent bone marrow relapse occurred in most patients. Twenty-seven of 29 patients whose cerebrospinal fluid was examined before or at the time of the onset of leukemic ophthalmopathy demonstrated meningeal leukemia. In contrast, this complication has not been observed in recent patients who received "prophylactic" treatment for meningeal leukemia. Leukemic invasion of the eye should receive appropriate recognition; the posterior pole should be included in the treatment of the central nervous system as a pharmacologic sanctuary.


Fungal infection of muscle in acute leukemia. A patient with acute lymphoblastic leukemia and granulocytopenia developed fever and diffuse muscle pain and weakness while under therapy. Blood cultures grew Candida Krusei and autopsy showed diffuse muscle fungal infestation.


Rosette formation with mouse erythrocytes. III. Studies in patients with primary immunodeficiency and lymphoproliferative disorders. Rosette formation with mouse erythrocytes and other cell-surface markers were examined on lymphocytes from patients with a variety of primary immunodeficiency and lymphoproliferative disorders. Mouse erythrocyte rosette-forming cells and lymphocytes with surface immunoglobulins were regularly absent in patients with Bruton type agammaglobulinaemia, immunodeficiency and thymoma syndrome and severe combined immunodeficiency disease. However, they were present in normal or low numbers in patients with common variable immunodeficiency, selective IgA deficiency and ataxis telangiectasia. Lymphocytes from patients with acute lymphoblastic leukaemia Sezary syndrome and mycosis fungoides made no or few rosettes with mouse erythrocytes. Increased numbers of mouse erythrocyte rosette-forming cells were present in patients with chronic lymphocytic leukaemia and Waldenstrom's macroglobulinaemia. The significance of the mouse erythrocyte rosette as a B-cell marker in the analysis of primary immunodeficiency and lymphoproliferative disorders is discussed.


[Technic and results of surgical tongue reduction]. The results of 53 surgical tongue reductions using a new line of incision are reported. Follow-ups were made in 31 of the cases. Hardly any unfavorable results are to be expected from this operation as far as postoperative shape of the tongue, mobility, taste, sensitivity, and speech are concerned. The positive effect on disturbed speech is especially worth mentioning.


[Differential diagnosis and therapy of chronic mandibular osteomyelitis]. It is often very difficult to differentiate between chronic osteomyelitis and osteogenic sarcoma which present rather similar clinical and radiological findings. In cases of doubt, the diagnosis must be confirmed by a biopsy. As therapy of chronic mandibular osteomyelitis, active surgery becomes more and more important.


[The nasopharynx in jaw compression--craniometric and rhinologic data]. 113 patients-7 to 29 years old-of the orthodontic department of the School of Dentistry, University of Minnesota, were studied. 51 patients had a high SN-MP angle (a long face) and 62 a low SN-MP angle (a broad face). As compared to the broad-faced group the probands with a long face showed, on the average, a narrower palatal arch, a more posteriorly postitioned hard palate, a smaller nasopharynx (measured in the sagittal plane), and more frequent nasopharyngeal problems. According to our statistical evaluation, a narrower maxillary dental arch and clinical apparent adenoid hypertrophy do not appear to be connected to each other in a cause-and-effect relationship. They rather seem to be two independent symptoms found frequently, though not necessarily in combination with each other, in persons with a long face.


[Biometric evaluation of clinical temporomandibular joint data, illustrated on the example of the mastication side]. By means of a special form developed by the authors and covering 535 clinical temporo-mandibular joint data, frequency and relation analyses were carried out in 80 patients at our outpatient clinic. In a biometric evaluation the relation between joint pain, joint noises and side of mastication is presented in cross-reference tables, and briefly discussed.


[Comparative studies on the incidence of caries in 10-year-old schoolchildren from Kiel and Landskrona (Sweden)]. Comparative clinical studies on the caries incidence of 10-year-old school children in Kiel and Landskrona (Sweden) showed after statistical evaluation that the Landskrona children had lesser DF surfaces than the Kiel children. A comparison of incidence broken up into separate D and F surfaces showed that the Kiel children had more D surfaces, while the children of Landskrona had more F surfaces. The connection between caries incidence and prophylactic measures is discussed.


[Diurnal differences in the effectiveness of an analgesic]. At different times of the day, the effect of an analgesic was systematically tested on healthy teeth by using a cold stimulus. The measure of the analgetic effect was the alteration of pain threshold measured by means of the minimum cold application time. In addition to the already known spontaneous variations in pain tolerance at the various times of the day, it was found that in the evening the effect of an analgesic is reduced and begins more slowly.


[Sealing dental enamel by means of photopolymerisable adhesives under exposure lasers light]. Electronmicroscopic examinations - analogous to those of the previous investigation [4] - suggest a relatively good interlocking of the adhesive with the conditioned dental enamel. In the demineralized microsections, clear differences are found among the strands of resin, in the light microscope. While they reach a length of 10 to 20 mum after UV light polymerisation, they become 100 to 200 mum long after exposure to laser light. First advantages resulting from these experiments are explained and critically discussed.


[Reproductibility of plaque formation in the dento-gingival region (2)]. In 3 subjects with clinically healthy, physio-morphologic gingiva, the time factor in plaque growth was studied in 6 tests. Plaque was highly reproducible with regard to its surface dimensions and location. This holds true of both types of subject, those tending to form great amounts and those tending to form small amounts of plaque. The multi-causal process of plaque genesis is demonstrated in the tested mandibular region by the differences in plaque extent between the central and lateral incisors on the one hand and the canines on the other. The more a proband trends to form plaque, the bigger this difference is.


[Dental caries in Southern Morocco. The role of socio-economic, ecological, racial geographic and nutritional factors]. 1,376 male inhabitants of 15 towns in Southern Marocco were studied. The caries incidence were found to be higher than expected in view of their stage of civilization and the remoteness of the area. Two factors were found to be the reason for the advanced caries incidence: the high sugar intake, mainly used to sweeten the often drunk tea, and the wide-spread date as the most important food. A negative correlation was found between fluoride content of the water and caries, but the negative influence of date consumption was stronger than the positive influence of fluoride.


[Masticatory force--mastication pressure--loading capacity]. The loading capacity of teeth is determined by various factors. Apart from size and quality of the surfaces to which force is transmitted, the shape of the root and how far it is inserted are especially important. It was found that primarily teeth with cylindrical roots can accept greater masticatory forces than teeth with tapered roots and react to a considerably smaller extent if the root is not deeply inserted. If the force applies outside the longitudinal axis running through the center of gravity, the loading capacity decreases with increasing distance.


[Testing of knowledge in the field of prosthetics]. At four dental schools of the Federal Republic of Germany, a joint test concerning knowledge in the field of prosthetics was carried out with 222 students and staff participating. Evaluation of the 76 multiple-choice questions showed that, on the whole, there are only small differences in knowledge from dental school. The questions permit a good differentiation between well and poorly informed participants.


[Prospects of surgical treatment in hydantoin-induced gingival hyperplasia]. During the past 20 years, gingivectomies were carried out in 100 out-patients of the maxillo-facial clinic of the Heidelberg university hospitals because of intensive gingival hyperplasia. 57% of the patients were epileptics who had been hydantoin-containing preparations. Follow-ups were made in 41 patients. The group of epileptics was critically compared with that of non-epileptics. In addition to the rate of recurrences, especially oral hygiene, existing bite abnormalities and the degree of mental retardation were considered. It was surprising that the number of recurrences did not drop when the hydantoin containing preparation was postoperatively discontinued. Even in edentulous regions of the jaws of two patients, recurrences of considerable size were found.


Recent developments in alloys for dental amalgams: their properties and proper use. Since the development more than ten years ago of a new type of amalgam alloy that will react with mercury without forming the unfavourable gamma2 (Sn7-8Hg) phase, several new alloy brands with a similar reaction pattern have been presented. This new generation of amalgam alloy is called non-gamma2 alloy as distinct from the conventional alloys. Three of the new alloys studied contain approximately three volume percent gamma2 and should be classified as modified concentional amalgams. The non-gamma2 amalgams may be characterized in the following way: (1) instead of gamma2 they contain a reaction product of copper and tin (Cu6Sn5), the so-called eta1 phase. (2) They are significantly more resistant to corrosion than the conventional amalgams but do in time produce sufficient solid corrosion products to seal the micro-fissures between filling and cavity walls. (3) When corroding, they do not release metallic mercury, and the solid corrosion products formed and precipitated on the free surface of the fillings seem relatively little resistant to the organic acids of the plaque. (4) Most of them have relatively low creep and tensile strength, but high compressive strength. (5) Clinically the non-gamma2 amalgams are remarkable for superior marginal integrity and, seemingly, also for improved persistence of surface lustre.


Exfoliative cytologic examinations in the early diagnosis of oral cancer. Oral cytology-in spite of the wide extension of the use of cytologic diagnostic methods in various branches of medicine was and is the subject of many controversies. Opinions concerning the reliability of oral exfoliative cytology differ but all agree upon one point, oral cytology is not a substitute for biopsy. The main value of oral exfoliative cytology seems to lie in the diagnosis of malignant tumours, but differs according to the stages of progression of the disease. Comparison of cytological and histological results in oral carcinomas according to various authors gave a false negative rate of between 0 and 31 per cent. Advanced oral carcinomas already arouse suspicion at clinical examination and indicate the need for a biopsy. Therefore, in spite of the frequent ulceration increasing the effectiveness of cytodiagnostics, the importance of exfoliative cytology in advanced tumours is diminished. Exfoliative cytology may act as an important diagnostic aid in early oral carcinomas with ulcerated surfaces, even in some clinically unsuspected cases malignancy can be detected. In multiple or extensive lesions the selection of the most suitable site for the biopsy is possible. In leukoplakia the effectiveness of cytology is still more subject to dispute, the rate of false negatives is reported as high as to 63-9 per cent. However, when taking the clinical type of leukoplakia into consideration, the erosive leukoplakias which are known to be more inclined to become malignant showed a 76-6 per cent reliability of cytodiagnosis.


Corticosteroids in diseases of the oral mucosa. The introduction of corticosteroids into oral medicine heralded a therapeutic advance, and substantial benefits have occurred from their use. Three topical steroids are being used currently in oral diseases, i.e. hydrocortisone hemisuccinate, triamcinolone in Orabase 0-1 per cent and betamethasone valerate 0-1 mg. The efficacy of these agents can be increased markedly if they are administered during the prodromal phase of ulceration, i.e. when lymphocyte activity is at its maximum. Therapeutic doses of all of them can be exceeded three times without impairing adrenal function. Nevertheless some of these preparations, as exemplified by topical medication, induced an unfortunate acute pseudomembranous candidiasis without any alteration in the plasma cortisol level. The routine examination and treatment of ulcers in the mouth should be a careful exercise helped by a good light source and a tongue spatula. Oral lesions affecting the soft tissues may be often difficult to diagnose, because of the rapid occurrence of secondary changes, such as maceration from moisture, abrasion by food and teeth, perhaps, and the existence of erosions and ulcerations from ruptured vesicles or bullae. Thus, diagnosis will depend not only on the grouping and distribution of lesion, but also on its subsequent behaviour. In some cases too there will be associated changes in the facial skin or elsewhere in the body.


Dental manpower needs in a developing community: a critical analysis of the West African scene. Research findings from various countries in West Africa clearly indicate that over 94 per cent of the adult population above 40 years of age suffer from periodontal disease in various degrees of severity. Those living in rural areas in West Africa, where dental health care services are not yet available, suffer more from this common disease. With progressive urbanization and changes in diet and eating habits, consumption of refined sugars is rising steeply (Table II) and dental caries has become a serious problem particularly in children from high socioeconomic homes. In Nigeria, DMF of 4-3 in the female and 3-9 in the male has been reported. There is general paucity of all cadres of dental manpower in all areas in West Africa. Dentist: population ratios range from 1 : 111,000 in Senegal to 1 : 1,935,000 in Tchad Republic (Table I). In Senegal, Ghana and Nigeria, Dental schools have been established and attempts are being made to meet the pressing need for dental manpower by the expansion of existing treatment centres and training institutions and the establishment of new ones (Table IV & V). Emphasis is laid on preventive dental health care programmes and the formal training of dental auxiliary personnel: Dental Therapists, Dental Hygienists, Dental Technicians and Dental Surgery Assistants, is taking place in Nigeria and Senegal. Dental Nurses/Therapists and Dental Hygienists if adequately trained in sufficient numbers can play an all-important role in the delivery of dental care and the execution of preventive programmes in the vast rural areas in the developing countries of West Africa with a population of over 122 million people.


What a public health planner wants from a periodontal assessment. Despite certain shortcomings, the assessment of caries using the DMF system of scoring is relatively simple, reproducible and provides some indication of treatment needs and the success of the treatment measures provided. No such index is yet in existence which will give similar information about the much more complicated disease processes involved in periodontal disease. Early attempts to introduce suitable indices included the PI index PMA and OHI indices with their modifications. These indices have performed best in assessing disease status but gave little or no information about treatment needs, treatment achievement or failure. WHO attempted to simplify the indices so that they could be scored on a present or absent basis, but clinical trials revealed the impossibility of maintaining comparability even on this level. Subsequent refinement of the procedure has produced improvements in the system including the recording of five categories of treatment needs, namely special oral hygiene instruction, prophylaxis and oral hygiene, instruction, periodontal therapy without extraction of teeth and periodontal therapy with extraction of some or all teeth. The system is described in the second edition of the WHO manual on Oral Health Surveys. There is still need for epidemiologists to further refine the criteria of periodontal disease and to identify the significance of the various signs of gingival and periodontal pathology.


A practical approach to orthodontic treatment for the adult patient. The possibilities of treating malocclusions in adults are discussed and four cases of orthodontic treatment undergone by adults are described. Proper treatment can bring about improvements in most cases but it is neither necessary nor advisable to attempt a complete correction of all irregularities.


The effect of two commercial antibacterial mouthrinses on plaque growth in vivo. An experimental study was designed to compare the claimed antibacterial effect of Betadine and Blend-a-med Fluid with the known plaque growth inhibiting effect of a 0.2% aqueous solution of chlorhexidine digluconate (Hibitane). Before the test perios for 5 days. During the following week they cleaned their teeth mechanically with toothbrush and toothpicks. For the third week the students were divided into three experimental groups. Following closely the manufacturers' recommendations, one group rinsed their mouths four times daily with 10 ml of Betadine, one group every 2 hours with a glassful of water containing 5-8 drops of Blend-a-med Fluid, and the control group twice daily with 10 ml of the 0.2% chlorhexidine solution. Mechanical cleaning of the teeth was not allowed during the experimental week. The Plaque Index scorings decreased significantly from the end of the no-hygiene to the end of the mechanical cleaning period. During the experimental period a further decrease of the mean P1I scores returned to the level recorded after the no-hygiene period. As neither Betadine nor Blend-a-med Fluid proved able to prevent plaque growth in vivo, there seems to be no indication for their use in treatment of gingivitis.


The possible pathogenesis of gingival recession. A histological study of induced recession in the rat. Stages in the pathogenesis of gingival recession were observed in rats in which pocketing had been induced by replacement of natural incisors with dental implants. Suitable conditions were thus created on the palatal aspect of the implant sockets for recession to occur. The recession process was examined at intervals by taking transverse serial sections. In the epithelial and connective tissues deep to the receding margin, morphological changes were seen which apparently lead to cleft formation and recession. These appeared to be associated with mononuclear cell infiltration of the connective tissue. The study suggests that gingival recession involves a localized inflammatory process which causes breakdown of connective tissue and leads to proliferation of the epithelium into the site of connective tissue destruction. Proliferation of the epithelial cells into the connective tissue brings about a subsidence of the epithelial surface, which is manifest clinically as recession.


The healing potential of the periodontal tissues following different techniques of periodontal surgery in plaque-free dentitions. A 2-year clinical study. A clinical trial was undertaken to study the healing capacity of the periodontal tissues following different modes of periodontal surgery in patients whose oral hygiene was professionally maintained at an optimal level. Fifty patients, distributed into five groups, participated in the study. Following an initial examination and presurgical treatment, the various patient groups were subjected to one of the following surgical procedures: 1) the apically repositioned flap operation including elimination of bony defects, 2) the apically repositioned flap operation including curettage of the bony defects but without removal of bone, 3) the "Widman flap" technique including elimination of bony defects, 4) the "Widman flap" technique including curettage of the bony defects but without removal of bone, 5) gingivectomy including curettage of the bony defects but without removal of bone. After surgery, all patients received oral hygiene instruction and professional cleaning of the teeth once every 2 weeks during a 2-year period. The results showed that periodontal disease can be cured and further destruction of the periodontal tissues avoided irrespective of the surgical technique utilized for pocket elimination. Different surgical techniques, however, promoted varying degrees of regeneration of the supporting tissues. The most favourable healing was obtained when resection of bone was avoided and when complete coverage of the alveolar bone was ensured.


Free grafts of palatal mucosa on the lingual aspect of the mandible. A report of two cases. The importance of an adequate amount of keratinized and attached gingiva to maintain gingival health has been stressed by several authors (Friedman & Levine 1964, Lang & Löe 1972, Bernimoulin & Mühlemann 1973) and though the rationale for increasing the width of the gingiva applies equally well to both the lingual and the vestibular surfaces, only one report of a graft on the lingual aspect of the mandible in dentate patients has been found in the literature (Goldman & Cohen 1973). The object of this report is to describe the indications, the surgical procedure devised and the results obtained in two patients.


Skills analysis of a class I amalgam restoration in a mandibular right first molar. 1. Students changed their body position 32% more often than instructors during amalgam condensation. 2. Experienced instructors used 38% fewer strokes than students to condense the amalgam. 3. On the average, instructors used 65% less time per condensation stroke than students. This was not due to ability to move the instrument more quickly, since both students and instructors had similar minimum stroke times, but rather to the fact that instructors performed slowly less often. 4. The upstroke during condensation required nearly the same time for both students and instructors (an eight percent difference). It was the downstroke that was greatly different (a 96% difference). 5. Instructors repeated condensation strokes 22% more often than students, working more systematically with less "jumping around" in the cavity. 6. The total number of carving strokes was not related to experience. 7. Students repeated carving strokes more often than instructors. 8. Students and instructors tended to use the same length of strokes in carving. 9. There was a noticeable difference between instructors and students in the method used to grasp the instruments.


Cell-mediated destruction of human leukemic cells by MHC identical lymphocytes: requirement for a proliferative trigger in vitro. These experiments have investigated cellular mechanisms involved in the generation of cellular immune responses to human acute leukemic blasts. Because normal human lymphocytes are not able to recognize immunologically, in vitro, lymphocytes from MHC identical siblings, the present studies have examined the in vitro proliferative and cytotoxic responses of normal lymphocytes to MHC identical AML and ALL blasts. In those cases where acute leukemic cells were unable to induce a proliferative response by MHC identical lymphocytes, the generation of effective anti-leukemic cytotoxicity required the addition of unrelated stimulating cells to the sensitization culture. In contrast, leukemic blasts that induced a proliferative response by MHC identical lymphocytes were also able to stimulate anti-leukemic cytotoxicity. This could be augmented by the addition of unrelated stimulating cells to the sensitization culture. The specificity of anti-leukemic cell cytotoxicity was demonstrated in all instances by simultaneous testing of putative killer cells on 51Cr leukemic blasts as well as 51Cr-labeled MHC identical phytohemagglutinin blasts or normal lymphocytes. Simultaneous sensitization to MHC identical leukemic blasts and unrelated stimulating lymphocytes did not invariably generate anti-leukemic cytotoxicity even when allogeneic cytotoxicity was observed; the absence of demonstrable suppressor activity in these nonreactive combinations suggested that some individuals may be specifically immunoincompetent, and thereby unable to generate effective anti-leukemic CML.


[Studies on alumina ceramics for dentistry--sinterable alumina for core material-- (author's transl)]. This study has been performed to introduce the industrial alumina ceramics having superior physico-chemical properties and desirable color for human tooth into dental field. The following results have been obtained through a series of experiments: 1) Effects of sintering of pure alumina powder were promoted more remarkably by adding a couple of additive together than by adding each, independently. 2) By adding a couple of additive, Li2O-Nb2O5 or MgO-Nb2O5, the effect of sintering was higly promoted, and tooth colored specimen was obtained. 3) At the alumina specimen sintered with 0.125 mol% of Nb2O5, a few initial shrinkage was seen and the process was followed by slowly increasing shrinkage through a rapid rate of heating. This suggested that a rapid heating was possible to be tried by using above additives. 4). The alumina ceramics with a couple of MgO-Nb2O5 prepared by heating at 1500 degrees C for 100 min., showed maximum bending strength of 42 kg/mm2 and 92.3 of R.A. hardness, which are rather higher value among other alumina ceramics. Though the luminosity might be too higher, chromaticity was as same as that of tooth shade.


[Studies on the strength and the cutting performance of dental canal reamer. (I) Strength properties of raw materials of dental canal reamer and these standard (author's transl)]. Pulp canal reamers have been widely used for dental treatments of the root of teeth. The work's accuracy and cutting capability of these instruments are treated by the standarization of JIS and ADA etc. Especially Japanese industrial standarization (JIS) treated the dimensions of the configurations, materials and ability of dental canal reamers. But there is no report of the studies on the work and fracture strength of these dental instruments. So, this paper makes a report on these problems, which are the measurements of the diameter of the bite tips, are concerned the strength of the raw materials of dental canal reamers and are compared with the standarization (JIS) of these instruments. Test of the raw materials of reamers are tensile properties and are measured the strength and elasticity of these materials. And phase of fracture of these materials are investigated with the scanning electric microscope and the fracture modes are compared with the tensile strength properties.


[Studies on the strength and the cutting performance of dental canal reamer. (II). Torsional strength and tip diameter of dental canal reamers (author's transl)]. Strength of pulp canal reamers are important problems for cutting treatments of the root of tooth at the dental regions. Reamers have been used as cutting tools by the twisting movements, and then, fracture of reamers are especially caused by the shearing stress at the bite tips. So, this paper treated the shear strength of dental canal reamers, which are torsional strength and twisting rigidity of these cutting instruments. And we made the torsional apparatus for cutting and twisting tests, and tested the torsional strength of raw materials and pulp canal reamers. Type of reamer's configuration are treated by Japanese industrial standard (JIS) and these properties are readjusted with dimensions of diameter of reamers. Shear strength of reamers are 120 approximately 140 kg/mm2 and strength of straight bar with taper are about two times of that of reamers which are about 40 kg/mm2 (except reamer's number 1, 2). Scattering of value of strength and torsional angle of these reamers are examined and showed the range of scattering of these properties. Effectiveness of torsional angle on the fracture properties are considered on the clinical treatments and treated the safety of fracture of these reamers.


[On deformation of Au-Pt alloys caused by heat treatment (I) (author's transl)]. We made fifteen kinds of Au-Pt alloy each of which contain 69% gold. We measured the changes of hardness, the deformations of these alloys caused by heat treatment and also the thermal expanison coefficient of these alloys. The results were as follows. 1. The hardness of these alloys as they were cast almost the same as that of those, hardened by heat treatment. 2. The hardest alloy, as cast or hardened by heat treatment, contained 5% platinum, 20% copper and 5% silver. 3. The ability of these alloys to be hardened and softened by heat treatment was strengthened as the amount of platinum decreased and equally as the amount of copper increased. 4. The deformation of these alloys caused by heat treatment decreased as the amount of platinum increased and equally as the amount of copper decreased. 5. The deformation caused by heat treatment of these alloys which were caset by using phosphate-bonded investment was smaller than those of those alloys were cast by using gypsum investment. 6. The thermal expansion (100 degrees C approximately 400 degrees C) of these alloys as cast was larger than that of the alloys which were heated by softening treatment. The thermal-expansion-coefficient and temperature curves of these alloys as they were cast, were at 350 degrees C in the respective maximum point. On the other hand, the thermal-expansion-coefficient and temperature curves of the alloys which were heated by softening treatment, were at 175 degrees C in the respective minimum point.