From that article:  As a PrEP user myself, I admit that reading about this lends me pause. Is daily use really protecting me from HIV? Do I have a rational reason to be afraid? Will I be the next nameless patient presented on a poster board at a scientific convention on diseases? Then, I remind myself that if these transmissions were commonplace, we would have seen a lot more of them. If these resistant strains so easily "broke through" PrEP's 99% protection, we would have seen clusters of cases reported in 2015 in Toronto, where this initially occurred, and we'd be seeing a lot more of these events in San Francisco after this latest report.  However, instead of hearing about masses of HIV transmissions, PrEP seroconversions with verified adherence remains limited to three individuals in the world: one each in Toronto, San Francisco, and Amsterdam (the latter of which did not happen as a result of a resistant strain). With more than 356,700 people currently using PrEP worldwide, three cases still places HIV's protection at much greater than 99%. Or as Grant said: "We talk about these rare cases when they happen. It's not as sexy to talk about all the cases where that didn't happen, and how well PrEP protected people under the same exact circumstances." * * * * *  "Occasionally I wonder, 'Should I start asking my partners to use condoms before fucking me in the ass?' But then I think 'Relax! Three cases of PreP-resistant AIDS is nothing to worry about!"   Said no sane person ever.