A recent study that combined different approaches to compare #GWAS analyses against healthy controls and using heterogeneity tests in systemic #lupus erythematosus patients with biopsy-proven or never developed lupus #nephritis (LN) identified significant variants in HLA, TNFAIP3, BLK, and STATA loci specifically for LN patients. Direct LN-versus-non LN associations showed no statistically significant variants but heterogeneity tests revealed other genetic loci, including ELF1, OX40, DUSP22, and TPCN2. These findings suggest that individual subphenotypes may have varying #genetic predisposition.

*Chan SCW, Lei Y, Yap DYH, et al. Distinct genetic risk loci between biopsy-proven renal and non-renal lupus: a 10-year longitudinal cohort. Rheumatology (Oxford), 2025.
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#GWAS #lupus #nephritis