You shouldn't roofie your friends.
James is attracted to his friend Laura, but she turned him down when he asked her out.
James wants to hook up with Laura.
James waits until Laura is bored and horny late one night, and they have sex.
James throws a party at his house, slips Rohypnol into Laura's drink, and has sex with her while she's passed out.
The sex is fine, but James eventually realizes he isn't really compatible with Laura and moves on.
Laura goes to the police and James is identified from DNA evidence and convicted.