{"instruction": "You are an expert in relationship extraction. Please extract relationship triples that match the schema definition from the input. Return an empty list for relationships that do not exist. Please respond in the format of a JSON string.", "schema": ["adverse effect"], "input": "DISCUSSION : The main adverse effects of leflunomide consist of diarrhea , nausea , liver enzyme elevation , hypertension , alopecia , and allergic skin reactions ."}
{"adverse effect": [{"subject": "diarrhea", "object": "leflunomide"}, {"subject": "nausea", "object": "leflunomide"}, {"subject": "liver enzyme elevation", "object": "leflunomide"}, {"subject": "hypertension", "object": "leflunomide"}, {"subject": "alopecia", "object": "leflunomide"}, {"subject": "allergic skin reactions", "object": "leflunomide"}]}