{"instruction": "You are an expert in relationship extraction. Please extract relationship triples that match the schema definition from the input. Return an empty list for relationships that do not exist. Please respond in the format of a JSON string.", "schema": ["adverse effect"], "input": "During dose - finding studies for intravenous proton pump inhibitors omeprazole and pantoprazole , three of six young female volunteers receiving omeprazole and two young female volunteers receiving pantoprazole developed peripheral edema within 8 hr when high doses of the proton pump inhibitors were applied by continuous infusion together with large volumes of fluid ."}
{"adverse effect": [{"subject": "peripheral edema", "object": "omeprazole"}, {"subject": "peripheral edema", "object": "pantoprazole"}]}