{"instruction": "You are an expert in event extraction. Please extract events from the input that conform to the schema definition. Return an empty list for events that do not exist, and return NAN for arguments that do not exist. If an argument has multiple values, please return a list. Respond in the format of a JSON string.", "schema": [{"event_type": "potential therapeutic event", "trigger": true, "arguments": ["Treatment.Freq", "Subject.Gender", "Subject.Population", "Treatment.Time_elapsed", "Combination.Drug", "Treatment.Route", "Treatment", "Treatment.Dosage", "Treatment.Disorder", "Subject", "Treatment.Drug", "Subject.Disorder", "Subject.Race", "Subject.Age", "Effect"]}, {"event_type": "adverse event", "trigger": true, "arguments": ["Treatment.Disorder", "Treatment.Drug", "Subject.Age", "Treatment", "Treatment.Dosage", "Effect", "Treatment.Route", "Subject.Race", "Treatment.Freq", "Treatment.Time_elapsed", "Subject.Gender", "Subject.Disorder", "Subject.Population", "Subject", "Treatment.Duration", "Combination.Drug"]}], "input": "An episode of leukoencephalopathy is reported in a 13-year-old girl who, after standard radiotherapy for a posterior fossa medulloblastoma, received 8 treatments with a protocol containing a 4-hour infusion of 500 mg/m2 methotrexate and 12 mg intrathecal methotrexate."}
{"potential therapeutic event": [], "adverse event": [{"trigger": "after ", "arguments": {"Treatment.Disorder": "NAN", "Treatment.Drug": ["radiotherapy", "intrathecal methotrexate", "methotrexate"], "Subject.Age": "13-year-old", "Treatment": "standard radiotherapy for a posterior fossa medulloblastoma, received 8 treatments with a protocol containing a 4-hour infusion of 500 mg/m2 methotrexate and 12 mg intrathecal methotrexate", "Treatment.Dosage": ["500 mg/m2", "12 mg"], "Effect": "leukoencephalopathy", "Treatment.Route": "infusion", "Subject.Race": "NAN", "Treatment.Freq": "NAN", "Treatment.Time_elapsed": "NAN", "Subject.Gender": "girl", "Subject.Disorder": "NAN", "Subject.Population": "NAN", "Subject": "13-year-old girl who", "Treatment.Duration": "NAN", "Combination.Drug": "NAN"}}]}