{"instruction": "You are an expert in event extraction. Please extract events from the input that conform to the schema definition. Return an empty list for events that do not exist, and return NAN for arguments that do not exist. If an argument has multiple values, please return a list. Respond in the format of a JSON string.", "schema": [{"event_type": "potential therapeutic event", "trigger": true, "arguments": ["Subject", "Effect", "Treatment.Drug", "Subject.Disorder", "Subject.Gender", "Subject.Race", "Treatment", "Treatment.Dosage", "Treatment.Duration", "Combination.Drug", "Subject.Age", "Treatment.Time_elapsed"]}, {"event_type": "adverse event", "trigger": true, "arguments": ["Subject.Race", "Subject", "Treatment.Freq", "Treatment.Disorder", "Subject.Age", "Treatment.Dosage", "Subject.Disorder", "Treatment", "Treatment.Time_elapsed", "Effect", "Treatment.Route", "Treatment.Drug", "Treatment.Duration", "Subject.Population", "Subject.Gender", "Combination.Drug"]}], "input": "CONCLUSIONS: This observation of \"on-off\" risperidone treatment suggests that risperidone may have worsened both psychiatric and physical manifestations of the mitochondrial disorder in this adolescent."}
{"potential therapeutic event": [], "adverse event": [{"trigger": "have worsened ", "arguments": {"Subject.Race": "NAN", "Subject": "mitochondrial disorder in this adolescent", "Treatment.Freq": "NAN", "Treatment.Disorder": "NAN", "Subject.Age": "adolescent", "Treatment.Dosage": "NAN", "Subject.Disorder": "mitochondrial disorder", "Treatment": "risperidone", "Treatment.Time_elapsed": "NAN", "Effect": "psychiatric and physical manifestations", "Treatment.Route": "NAN", "Treatment.Drug": "risperidone", "Treatment.Duration": "NAN", "Subject.Population": "NAN", "Subject.Gender": "NAN", "Combination.Drug": "NAN"}}]}