{"instruction": "You are an expert in relationship extraction. Please extract relationship triples that match the schema definition from the input. Return an empty list for relationships that do not exist. Please respond in the format of a JSON string.", "schema": ["adverse effect"], "input": "The patient completed a 10-month follow - up , maintaining a complete resolution of the treated skin lesions ; however , the development of a painful hand ulcer , possibly associated with the hydroxyurea , and new skin cancers were observed at the last follow - up visit ."}
{"adverse effect": [{"subject": "painful hand ulcer", "object": "hydroxyurea"}, {"subject": "skin cancers", "object": "hydroxyurea"}]}