{"instruction": "You are an expert in event extraction. Please extract events from the input that conform to the schema definition. Return an empty list for events that do not exist, and return NAN for arguments that do not exist. If an argument has multiple values, please return a list. Respond in the format of a JSON string.", "schema": [{"event_type": "adverse event", "trigger": true, "arguments": ["Treatment.Freq", "Subject.Population", "Effect", "Treatment.Route", "Combination.Drug", "Subject.Gender", "Treatment.Duration", "Treatment.Disorder", "Subject.Disorder", "Subject", "Treatment.Dosage", "Treatment", "Subject.Age", "Subject.Race", "Treatment.Time_elapsed", "Treatment.Drug"]}, {"event_type": "potential therapeutic event", "trigger": true, "arguments": ["Subject", "Treatment.Duration", "Subject.Gender", "Combination.Drug", "Treatment.Drug", "Subject.Disorder", "Treatment.Time_elapsed", "Treatment", "Subject.Population", "Treatment.Disorder", "Treatment.Route", "Treatment.Dosage"]}], "input": "We review the literature on previously reported cases of cutaneous necrosis after injection of standard interferon alfa or pegylated interferon alfa-2b and discuss the different pathophysiologic mechanisms that might be involved."}
{"adverse event": [{"trigger": "after ", "arguments": {"Treatment.Freq": "NAN", "Subject.Population": "NAN", "Effect": "cutaneous necrosis", "Treatment.Route": "injection", "Combination.Drug": "NAN", "Subject.Gender": "NAN", "Treatment.Duration": "NAN", "Treatment.Disorder": "NAN", "Subject.Disorder": "NAN", "Subject": "NAN", "Treatment.Dosage": "NAN", "Treatment": ["pegylated interferon alfa-2b", "standard interferon alfa"], "Subject.Age": "NAN", "Subject.Race": "NAN", "Treatment.Time_elapsed": "NAN", "Treatment.Drug": ["pegylated interferon alfa-2b", "standard interferon alfa"]}}], "potential therapeutic event": []}