{"instruction": "You are an expert in event argument extraction. Please extract event arguments and their roles from the input that conform to the schema definition, which already includes event trigger words. If an argument does not exist, return NAN or an empty dictionary. Please respond in the format of a JSON string.", "schema": [{"event_type": "adverse event", "arguments": ["Subject.Gender", "Subject", "Treatment.Freq", "Subject.Race", "Treatment", "Treatment.Disorder", "Combination.Drug", "Treatment.Time_elapsed", "Treatment.Route", "Treatment.Duration", "Treatment.Drug", "Treatment.Dosage", "Effect", "Subject.Age", "Subject.Disorder"]}], "input": "After starting nevirapine treatment, nine out of ten patients experienced symptoms of abstinence syndrome, and methadone dose had to be increased by 20% on average during the course of the study."}
{"adverse event": [{"Subject.Gender": "NAN", "Subject": "nine out of ten patients", "Treatment.Freq": "NAN", "Subject.Race": "NAN", "Treatment": "nevirapine", "Treatment.Disorder": "NAN", "Combination.Drug": "NAN", "Treatment.Time_elapsed": "NAN", "Treatment.Route": "NAN", "Treatment.Duration": "NAN", "Treatment.Drug": "nevirapine", "Treatment.Dosage": "NAN", "Effect": "abstinence syndrome", "Subject.Age": "NAN", "Subject.Disorder": "NAN"}]}