{"instruction": "You are an expert in event extraction. Please extract events from the input that conform to the schema definition. Return an empty list for events that do not exist, and return NAN for arguments that do not exist. If an argument has multiple values, please return a list. Respond in the format of a JSON string.", "schema": [{"event_type": "adverse event", "trigger": true, "arguments": ["Treatment.Freq", "Subject.Population", "Treatment", "Treatment.Dosage", "Treatment.Route", "Subject.Gender", "Effect", "Subject", "Treatment.Duration", "Subject.Race", "Treatment.Time_elapsed", "Subject.Disorder", "Subject.Age", "Combination.Drug", "Treatment.Disorder", "Treatment.Drug"]}, {"event_type": "potential therapeutic event", "trigger": true, "arguments": ["Treatment.Route", "Combination.Drug", "Treatment", "Treatment.Dosage", "Effect", "Subject.Population", "Subject.Age", "Subject", "Treatment.Time_elapsed", "Subject.Gender", "Subject.Race"]}], "input": "We report a case of methotrexate toxicity potentially induced by a drug interaction between methotrexate and omeprazole in a 25-year-old man with osteosarcoma."}
{"adverse event": [{"trigger": "induced ", "arguments": {"Treatment.Freq": "NAN", "Subject.Population": "NAN", "Treatment": "methotrexate and omeprazole", "Treatment.Dosage": "NAN", "Treatment.Route": "NAN", "Subject.Gender": "man", "Effect": "methotrexate toxicity", "Subject": "a 25-year-old man with osteosarcoma", "Treatment.Duration": "NAN", "Subject.Race": "NAN", "Treatment.Time_elapsed": "NAN", "Subject.Disorder": "osteosarcoma", "Subject.Age": "25-year-old", "Combination.Drug": ["omeprazole", "methotrexate"], "Treatment.Disorder": "NAN", "Treatment.Drug": ["omeprazole", "methotrexate"]}}], "potential therapeutic event": []}