{"instruction": "You are an expert in event argument extraction. Please extract event arguments and their roles from the input that conform to the schema definition, which already includes event trigger words. If an argument does not exist, return NAN or an empty dictionary. Please respond in the format of a JSON string.", "schema": [{"event_type": "adverse event", "arguments": ["Subject.Population", "Effect", "Subject.Race", "Treatment.Route", "Subject.Gender", "Treatment.Duration", "Subject.Age", "Treatment", "Treatment.Disorder", "Treatment.Dosage", "Subject", "Treatment.Drug", "Subject.Disorder", "Combination.Drug", "Treatment.Time_elapsed"]}], "input": "CASE PRESENTATION: We report a patient with CF who developed recurrent eosinophilia and severe persistent bronchospasm following repeated administration of preservative-free tobramycin by inhalation, beginning at 16 months of age."}
{"adverse event": [{"Subject.Population": "NAN", "Effect": "recurrent eosinophilia and severe persistent bronchospasm", "Subject.Race": "NAN", "Treatment.Route": "inhalation", "Subject.Gender": "NAN", "Treatment.Duration": "NAN", "Subject.Age": "16 months", "Treatment": "repeated administration of preservative-free tobramycin by inhalation", "Treatment.Disorder": "CF", "Treatment.Dosage": "NAN", "Subject": ["a patient with CF", "beginning at 16 months of age"], "Treatment.Drug": "tobramycin", "Subject.Disorder": "NAN", "Combination.Drug": "NAN", "Treatment.Time_elapsed": "NAN"}]}