{"instruction": "You are an expert in event extraction. Please extract events from the input that conform to the schema definition. Return an empty list for events that do not exist, and return NAN for arguments that do not exist. If an argument has multiple values, please return a list. Respond in the format of a JSON string.", "schema": [{"event_type": "adverse event", "trigger": true, "arguments": ["Treatment.Route", "Subject.Population", "Subject.Gender", "Subject.Age", "Treatment.Dosage", "Subject.Race", "Subject.Disorder", "Combination.Drug", "Treatment.Disorder", "Treatment.Drug", "Effect", "Subject", "Treatment.Duration", "Treatment.Freq", "Treatment", "Treatment.Time_elapsed"]}, {"event_type": "potential therapeutic event", "trigger": true, "arguments": ["Treatment.Disorder", "Treatment.Freq", "Subject.Disorder", "Effect", "Treatment.Time_elapsed", "Treatment.Route", "Subject.Race", "Subject.Gender", "Subject.Age", "Treatment.Dosage", "Subject.Population", "Treatment.Drug", "Treatment"]}], "input": "Coadministration of 200 mg bid voriconazole with 400 mg (or higher) qd efavirenz is contraindicated due to the clinically significant effect of efavirenz on voriconazole pharmacokinetics."}
{"adverse event": [{"trigger": "contraindicated ", "arguments": {"Treatment.Route": "NAN", "Subject.Population": "NAN", "Subject.Gender": "NAN", "Subject.Age": "NAN", "Treatment.Dosage": ["200 mg", "400 mg"], "Subject.Race": "NAN", "Subject.Disorder": "NAN", "Combination.Drug": ["voriconazole", "efavirenz"], "Treatment.Disorder": "NAN", "Treatment.Drug": ["voriconazole", "efavirenz"], "Effect": "clinically significant effect", "Subject": "NAN", "Treatment.Duration": "NAN", "Treatment.Freq": "NAN", "Treatment": ["efavirenz on voriconazole", "Coadministration of 200 mg bid voriconazole with 400 mg (or higher) qd efavirenz"], "Treatment.Time_elapsed": "NAN"}}], "potential therapeutic event": []}