{"instruction": "You are an expert in event extraction. Please extract events from the input that conform to the schema definition. Return an empty list for events that do not exist, and return NAN for arguments that do not exist. If an argument has multiple values, please return a list. Respond in the format of a JSON string.", "schema": [{"event_type": "potential therapeutic event", "trigger": true, "arguments": ["Treatment.Route", "Treatment.Disorder", "Combination.Drug", "Treatment.Duration", "Treatment", "Treatment.Freq", "Subject.Age", "Subject.Race", "Subject.Population", "Treatment.Dosage"]}, {"event_type": "adverse event", "trigger": true, "arguments": ["Treatment.Duration", "Treatment.Disorder", "Treatment.Drug", "Treatment.Freq", "Treatment.Time_elapsed", "Subject.Disorder", "Treatment.Dosage", "Combination.Drug", "Subject", "Effect", "Subject.Population", "Subject.Race", "Treatment.Route", "Subject.Age", "Subject.Gender", "Treatment"]}], "input": "Our findings suggest that significant progression of marrow reticulin fibrosis during imatinib therapy can be an indicator for a return or progression of CML and, in some patients with CML, imatinib may promote cytogenetic clonal evolution, resulting in a poor response to treatment."}
{"potential therapeutic event": [], "adverse event": [{"trigger": "during ", "arguments": {"Treatment.Duration": "NAN", "Treatment.Disorder": "NAN", "Treatment.Drug": "imatinib", "Treatment.Freq": "NAN", "Treatment.Time_elapsed": "NAN", "Subject.Disorder": "NAN", "Treatment.Dosage": "NAN", "Combination.Drug": "NAN", "Subject": "NAN", "Effect": "significant progression of marrow reticulin fibrosis", "Subject.Population": "NAN", "Subject.Race": "NAN", "Treatment.Route": "NAN", "Subject.Age": "NAN", "Subject.Gender": "NAN", "Treatment": "imatinib"}}]}