{"instruction": "You are an expert in event extraction. Please extract events from the input that conform to the schema definition. Return an empty list for events that do not exist, and return NAN for arguments that do not exist. If an argument has multiple values, please return a list. Respond in the format of a JSON string.", "schema": [{"event_type": "adverse event", "trigger": true, "arguments": ["Subject.Disorder", "Treatment.Freq", "Subject", "Treatment.Time_elapsed", "Treatment.Route", "Subject.Race", "Subject.Age", "Treatment", "Treatment.Dosage", "Subject.Gender", "Treatment.Duration", "Subject.Population", "Treatment.Drug", "Treatment.Disorder", "Combination.Drug", "Effect"]}], "input": "Although they had only a few nodules at diagnosis, the nodules increased in number and size 3 to 4 months after the start of methotrexate therapy in both patients."}
{"adverse event": [{"trigger": "after ", "arguments": {"Subject.Disorder": "a few nodules", "Treatment.Freq": "NAN", "Subject": "a few nodules at diagnosis", "Treatment.Time_elapsed": "3 to 4 months", "Treatment.Route": "NAN", "Subject.Race": "NAN", "Subject.Age": "NAN", "Treatment": "methotrexate therapy", "Treatment.Dosage": "NAN", "Subject.Gender": "NAN", "Treatment.Duration": "NAN", "Subject.Population": "NAN", "Treatment.Drug": "methotrexate", "Treatment.Disorder": "NAN", "Combination.Drug": "NAN", "Effect": "the nodules increased in number and size"}}]}