{"instruction": "You are an expert in event argument extraction. Please extract event arguments and their roles from the input that conform to the schema definition, which already includes event trigger words. If an argument does not exist, return NAN or an empty dictionary. Please respond in the format of a JSON string.", "schema": [{"event_type": "adverse event", "arguments": ["Subject.Population", "Treatment.Time_elapsed", "Subject.Age", "Treatment.Duration", "Combination.Drug", "Treatment.Drug", "Treatment.Disorder", "Treatment.Freq", "Treatment.Dosage", "Treatment.Route", "Effect", "Subject", "Subject.Disorder", "Treatment", "Subject.Gender", "Subject.Race"]}], "input": "Seizures occurred in two patients with probable Alzheimer's disease who were receiving long-term treatment with metrifonate, an irreversible acetylcholinesterase inhibitor."}
{"adverse event": [{"Subject.Population": "two", "Treatment.Time_elapsed": "NAN", "Subject.Age": "NAN", "Treatment.Duration": "NAN", "Combination.Drug": "NAN", "Treatment.Drug": "metrifonate", "Treatment.Disorder": "Alzheimer's disease", "Treatment.Freq": "NAN", "Treatment.Dosage": "NAN", "Treatment.Route": "NAN", "Effect": "Seizures", "Subject": "two patients with probable Alzheimer's disease", "Subject.Disorder": "NAN", "Treatment": "long-term treatment with metrifonate", "Subject.Gender": "NAN", "Subject.Race": "NAN"}]}