{"instruction": "You are an expert in event extraction. Please extract events from the input that conform to the schema definition. Return an empty list for events that do not exist, and return NAN for arguments that do not exist. If an argument has multiple values, please return a list. Respond in the format of a JSON string.", "schema": [{"event_type": "adverse event", "trigger": true, "arguments": ["Subject", "Treatment.Disorder", "Treatment.Time_elapsed", "Treatment.Route", "Treatment.Dosage", "Combination.Drug", "Subject.Disorder", "Treatment.Drug", "Treatment.Freq", "Effect", "Subject.Age", "Treatment", "Subject.Race", "Treatment.Duration", "Subject.Population", "Subject.Gender"]}, {"event_type": "potential therapeutic event", "trigger": true, "arguments": ["Treatment.Dosage", "Subject.Disorder", "Subject.Age", "Treatment.Freq", "Treatment.Duration", "Combination.Drug", "Treatment.Route", "Subject.Population", "Treatment", "Subject.Race", "Treatment.Time_elapsed"]}], "input": "However, in the mid-to-late 1980s, a series of letters to the editor and case reports announced an association between tamoxifen therapy in women with breast cancer and the development of endometrial carcinoma."}
{"adverse event": [{"trigger": "development ", "arguments": {"Subject": "women with breast cancer", "Treatment.Disorder": "breast cancer", "Treatment.Time_elapsed": "NAN", "Treatment.Route": "NAN", "Treatment.Dosage": "NAN", "Combination.Drug": "NAN", "Subject.Disorder": "NAN", "Treatment.Drug": "tamoxifen", "Treatment.Freq": "NAN", "Effect": "endometrial carcinoma", "Subject.Age": "NAN", "Treatment": "tamoxifen", "Subject.Race": "NAN", "Treatment.Duration": "NAN", "Subject.Population": "NAN", "Subject.Gender": "women"}}], "potential therapeutic event": []}