{"instruction": "You are an expert in event extraction. Please extract events from the input that conform to the schema definition. Return an empty list for events that do not exist, and return NAN for arguments that do not exist. If an argument has multiple values, please return a list. Respond in the format of a JSON string.", "schema": [{"event_type": "adverse event", "trigger": true, "arguments": ["Treatment.Route", "Treatment.Duration", "Treatment", "Subject.Age", "Treatment.Time_elapsed", "Treatment.Freq", "Subject", "Subject.Race", "Treatment.Disorder", "Subject.Population", "Treatment.Drug", "Subject.Disorder", "Effect", "Treatment.Dosage", "Subject.Gender", "Combination.Drug"]}, {"event_type": "potential therapeutic event", "trigger": true, "arguments": ["Treatment.Dosage", "Treatment", "Treatment.Route", "Subject.Gender", "Subject", "Treatment.Freq", "Effect", "Subject.Race", "Combination.Drug", "Subject.Population"]}], "input": "The successful development and implementation of this protocol will have impact on patients who have anaphylactic reactions to MTX but require this medication for specific diseases."}
{"adverse event": [{"trigger": "have ", "arguments": {"Treatment.Route": "NAN", "Treatment.Duration": "NAN", "Treatment": "MTX", "Subject.Age": "NAN", "Treatment.Time_elapsed": "NAN", "Treatment.Freq": "NAN", "Subject": "patients", "Subject.Race": "NAN", "Treatment.Disorder": "NAN", "Subject.Population": "NAN", "Treatment.Drug": "MTX", "Subject.Disorder": "NAN", "Effect": "anaphylactic reactions", "Treatment.Dosage": "NAN", "Subject.Gender": "NAN", "Combination.Drug": "NAN"}}], "potential therapeutic event": []}