{"instruction": "You are an expert in event argument extraction. Please extract event arguments and their roles from the input that conform to the schema definition, which already includes event trigger words. If an argument does not exist, return NAN or an empty dictionary. Please respond in the format of a JSON string.", "schema": [{"event_type": "adverse event", "arguments": ["Treatment.Dosage", "Treatment.Drug", "Subject.Gender", "Subject.Race", "Combination.Drug", "Treatment.Route", "Subject.Disorder", "Effect", "Treatment.Time_elapsed", "Treatment", "Treatment.Duration", "Treatment.Disorder", "Treatment.Freq", "Subject.Age", "Subject"]}], "input": "OBJECTIVE: To describe a case of exacerbated mania potentially related to an interaction between lopinavir/ritonavir and valproic acid (VPA) and propose a mechanism of action for this interaction."}
{"adverse event": [{"Treatment.Dosage": "NAN", "Treatment.Drug": ["ritonavir", "lopinavir", "valproic acid"], "Subject.Gender": "NAN", "Subject.Race": "NAN", "Combination.Drug": ["ritonavir", "valproic acid", "lopinavir"], "Treatment.Route": "NAN", "Subject.Disorder": "NAN", "Effect": "exacerbated mania", "Treatment.Time_elapsed": "NAN", "Treatment": "interaction between lopinavir/ritonavir and valproic acid", "Treatment.Duration": "NAN", "Treatment.Disorder": "NAN", "Treatment.Freq": "NAN", "Subject.Age": "NAN", "Subject": "NAN"}]}