{"instruction": "You are an expert in relationship extraction. Please extract relationship triples that match the schema definition from the input. Return an empty list for relationships that do not exist. Please respond in the format of a JSON string.", "schema": ["adverse effect"], "input": "We report the case histories of identical twin brothers who developed concordant acute lymphoblastic leukemia at the age of 4 years and who later developed leukoencephalopathy and hydrocephalus related to central nervous system prophylaxis by , in the first case intrathecally administered methotrexate and , in the second by intrathecally administered methotrexate and cranial irradiation ."}
{"adverse effect": [{"subject": "leukoencephalopathy", "object": "methotrexate"}, {"subject": "hydrocephalus", "object": "methotrexate"}]}