{"instruction": "You are an expert in event argument extraction. Please extract event arguments and their roles from the input that conform to the schema definition, which already includes event trigger words. If an argument does not exist, return NAN or an empty dictionary. Please respond in the format of a JSON string.", "schema": [{"event_type": "adverse event", "arguments": ["Treatment.Time_elapsed", "Combination.Drug", "Subject.Population", "Treatment.Dosage", "Subject.Race", "Subject.Age", "Treatment.Disorder", "Subject.Gender", "Subject.Disorder", "Treatment.Duration", "Treatment", "Treatment.Freq", "Treatment.Drug", "Treatment.Route", "Subject"]}], "input": "The human immunodeficiency virus protease inhibitor ritonavir is a potent inhibitor of the cytochrome P450 3A4 enzyme, and ritonavir's concomitant administration with the substrates of this enzyme may lead to dangerous drug interactions."}
{"adverse event": [{"Treatment.Time_elapsed": "NAN", "Combination.Drug": ["substrates of this enzyme", "ritonavir"], "Subject.Population": "NAN", "Treatment.Dosage": "NAN", "Subject.Race": "NAN", "Subject.Age": "NAN", "Treatment.Disorder": "NAN", "Subject.Gender": "NAN", "Subject.Disorder": "NAN", "Treatment.Duration": "NAN", "Treatment": "ritonavir's concomitant administration with the substrates of this enzyme", "Treatment.Freq": "NAN", "Treatment.Drug": ["substrates of this enzyme", "ritonavir"], "Treatment.Route": "NAN", "Subject": "NAN"}]}