{"instruction": "You are an expert in relationship extraction. Please extract relationship triples that match the schema definition from the input. Return an empty list for relationships that do not exist. Please respond in the format of a JSON string.", "schema": ["adverse effect"], "input": "With the use of optical coherence tomography ( OCT ) , two patients with IFN - associated retinopathy who had developed macular edema and reduced visual acuity during the clinical course of IFN therapy were observed ."}
{"adverse effect": [{"subject": "retinopathy", "object": "IFN"}, {"subject": "macular edema", "object": "IFN"}, {"subject": "reduced visual acuity", "object": "IFN"}]}