{"instruction": "You are an expert in event argument extraction. Please extract event arguments and their roles from the input that conform to the schema definition, which already includes event trigger words. If an argument does not exist, return NAN or an empty dictionary. Please respond in the format of a JSON string.", "schema": [{"event_type": "adverse event", "arguments": ["Treatment.Duration", "Treatment.Drug", "Treatment.Dosage", "Treatment.Disorder", "Subject.Age", "Subject.Race", "Treatment.Route", "Subject.Gender", "Effect", "Subject.Disorder", "Treatment.Time_elapsed", "Combination.Drug", "Treatment", "Treatment.Freq", "Subject.Population", "Subject"]}], "input": "The first reported case, in an adult, of cholestyramine induced hyperchloremic metabolic acidosis is a 70 year old female with a two year history of primary biliary cirrhosis confirmed by histologic and immunologic criteria."}
{"adverse event": [{"Treatment.Duration": "NAN", "Treatment.Drug": "cholestyramine", "Treatment.Dosage": "NAN", "Treatment.Disorder": "primary biliary cirrhosis", "Subject.Age": "70 year old", "Subject.Race": "NAN", "Treatment.Route": "NAN", "Subject.Gender": "female", "Effect": "hyperchloremic metabolic acidosis", "Subject.Disorder": "NAN", "Treatment.Time_elapsed": "NAN", "Combination.Drug": "NAN", "Treatment": "cholestyramine", "Treatment.Freq": "NAN", "Subject.Population": "NAN", "Subject": "a 70 year old female with a two year history of primary biliary cirrhosis"}]}