{"instruction": "You are an expert in event extraction. Please extract events from the input that conform to the schema definition. Return an empty list for events that do not exist, and return NAN for arguments that do not exist. If an argument has multiple values, please return a list. Respond in the format of a JSON string.", "schema": [{"event_type": "potential therapeutic event", "trigger": true, "arguments": ["Treatment", "Treatment.Dosage", "Subject.Population", "Subject", "Treatment.Disorder", "Subject.Race", "Treatment.Route", "Effect", "Subject.Gender", "Treatment.Time_elapsed", "Combination.Drug", "Treatment.Duration", "Subject.Age"]}, {"event_type": "adverse event", "trigger": true, "arguments": ["Treatment.Route", "Subject.Race", "Treatment.Disorder", "Combination.Drug", "Treatment", "Subject.Age", "Treatment.Duration", "Subject", "Subject.Disorder", "Treatment.Drug", "Treatment.Dosage", "Subject.Population", "Treatment.Time_elapsed", "Subject.Gender", "Treatment.Freq", "Effect"]}], "input": "With the use of optical coherence tomography (OCT), two patients with IFN-associated retinopathy who had developed macular edema and reduced visual acuity during the clinical course of IFN therapy were observed."}
{"potential therapeutic event": [], "adverse event": [{"trigger": "associated ", "arguments": {"Treatment.Route": "NAN", "Subject.Race": "NAN", "Treatment.Disorder": "NAN", "Combination.Drug": "NAN", "Treatment": "IFN", "Subject.Age": "NAN", "Treatment.Duration": "NAN", "Subject": "NAN", "Subject.Disorder": "NAN", "Treatment.Drug": "IFN", "Treatment.Dosage": "NAN", "Subject.Population": "NAN", "Treatment.Time_elapsed": "NAN", "Subject.Gender": "NAN", "Treatment.Freq": "NAN", "Effect": ["retinopathy", "macular edema and reduced visual acuity"]}}]}