{"instruction": "You are an expert in event extraction. Please extract events from the input that conform to the schema definition. Return an empty list for events that do not exist, and return NAN for arguments that do not exist. If an argument has multiple values, please return a list. Respond in the format of a JSON string.", "schema": [{"event_type": "potential therapeutic event", "trigger": true, "arguments": ["Treatment.Drug", "Subject.Age", "Treatment.Route", "Treatment.Freq", "Treatment.Duration", "Treatment.Dosage", "Treatment", "Subject.Disorder", "Combination.Drug", "Subject.Gender", "Effect", "Treatment.Time_elapsed", "Subject.Race", "Subject", "Treatment.Disorder", "Subject.Population"]}, {"event_type": "adverse event", "trigger": true, "arguments": ["Subject.Gender", "Treatment.Freq", "Subject.Population", "Combination.Drug", "Treatment.Disorder", "Treatment.Dosage", "Effect", "Treatment.Drug", "Treatment.Duration", "Treatment.Route", "Subject.Disorder", "Subject.Race"]}], "input": "Intrathecal chemotherapy with methotrexate or cytosine arabinoside is the standard approach to prophylaxis and treatment of central nervous system leukemia in children."}
{"potential therapeutic event": [{"trigger": "treatment ", "arguments": {"Treatment.Drug": ["cytosine arabinoside", "methotrexate"], "Subject.Age": "children", "Treatment.Route": "Intrathecal chemotherapy", "Treatment.Freq": "NAN", "Treatment.Duration": "NAN", "Treatment.Dosage": "NAN", "Treatment": "Intrathecal chemotherapy with methotrexate or cytosine arabinoside", "Subject.Disorder": "NAN", "Combination.Drug": "NAN", "Subject.Gender": "NAN", "Effect": "NAN", "Treatment.Time_elapsed": "NAN", "Subject.Race": "NAN", "Subject": "children", "Treatment.Disorder": "central nervous system leukemia", "Subject.Population": "NAN"}}], "adverse event": []}