{"instruction": "You are an expert in event argument extraction. Please extract event arguments and their roles from the input that conform to the schema definition, which already includes event trigger words. If an argument does not exist, return NAN or an empty dictionary. Please respond in the format of a JSON string.", "schema": [{"event_type": "adverse event", "arguments": ["Treatment.Dosage", "Treatment.Freq", "Subject.Race", "Combination.Drug", "Subject.Disorder", "Effect", "Treatment.Duration", "Treatment", "Subject.Population", "Subject.Age", "Subject.Gender", "Treatment.Route", "Subject"]}], "input": "Thalidomide has proven activity in refractory multiple myeloma (MM), and although single-agent thalidomide has minimal prothrombogenic activity, its combination with cytotoxic chemotherapy is associated with a significantly increased risk of DVT."}
{"adverse event": [{"Treatment.Dosage": "NAN", "Treatment.Freq": "NAN", "Subject.Race": "NAN", "Combination.Drug": ["cytotoxic", "thalidomide"], "Subject.Disorder": "NAN", "Effect": "significantly increased risk of DVT", "Treatment.Duration": "NAN", "Treatment": ["combination with cytotoxic chemotherapy", "single-agent thalidomide"], "Subject.Population": "NAN", "Subject.Age": "NAN", "Subject.Gender": "NAN", "Treatment.Route": "chemotherapy", "Subject": "NAN"}]}