{"instruction": "You are an expert in event extraction. Please extract events from the input that conform to the schema definition. Return an empty list for events that do not exist, and return NAN for arguments that do not exist. If an argument has multiple values, please return a list. Respond in the format of a JSON string.", "schema": [{"event_type": "adverse event", "trigger": true, "arguments": ["Treatment.Disorder", "Combination.Drug", "Subject.Age", "Effect", "Treatment.Time_elapsed", "Subject.Population", "Subject.Disorder", "Treatment.Route", "Subject.Race", "Treatment.Freq", "Treatment", "Subject", "Treatment.Duration", "Treatment.Drug", "Subject.Gender", "Treatment.Dosage"]}, {"event_type": "potential therapeutic event", "trigger": true, "arguments": ["Treatment.Freq", "Treatment.Dosage", "Treatment.Disorder", "Treatment.Route", "Combination.Drug", "Subject.Gender", "Treatment.Time_elapsed", "Subject.Population", "Treatment", "Subject.Age", "Subject.Disorder", "Treatment.Drug", "Treatment.Duration"]}], "input": "Four patients receiving high-dose tamoxifen for greater than 1 year have demonstrated similar retinal changes."}
{"adverse event": [{"trigger": "receiving ", "arguments": {"Treatment.Disorder": "NAN", "Combination.Drug": "NAN", "Subject.Age": "NAN", "Effect": "retinal changes", "Treatment.Time_elapsed": "NAN", "Subject.Population": "Four", "Subject.Disorder": "NAN", "Treatment.Route": "NAN", "Subject.Race": "NAN", "Treatment.Freq": "NAN", "Treatment": "high-dose tamoxifen for greater than 1 year", "Subject": "Four patients", "Treatment.Duration": "1 year", "Treatment.Drug": "tamoxifen", "Subject.Gender": "NAN", "Treatment.Dosage": "high-dose"}}], "potential therapeutic event": []}