{"instruction": "You are an expert in event extraction. Please extract events from the input that conform to the schema definition. Return an empty list for events that do not exist, and return NAN for arguments that do not exist. If an argument has multiple values, please return a list. Respond in the format of a JSON string.", "schema": [{"event_type": "adverse event", "trigger": true, "arguments": ["Subject", "Treatment.Route", "Combination.Drug", "Treatment.Drug", "Treatment.Disorder", "Treatment", "Subject.Age", "Subject.Race", "Treatment.Duration", "Subject.Gender", "Treatment.Time_elapsed", "Treatment.Dosage", "Subject.Population", "Effect", "Subject.Disorder", "Treatment.Freq"]}, {"event_type": "potential therapeutic event", "trigger": true, "arguments": ["Treatment.Time_elapsed", "Subject.Gender", "Treatment.Duration", "Subject.Race", "Treatment", "Subject.Population", "Subject.Disorder", "Subject", "Effect", "Subject.Age", "Treatment.Disorder", "Combination.Drug"]}], "input": "There have been more than 20 observations of the appearance or aggravation of this granulomatosis with interferon alfa and more recently with the combination of interferon alfa plus ribavirin."}
{"adverse event": [{"trigger": "with ", "arguments": {"Subject": "NAN", "Treatment.Route": "NAN", "Combination.Drug": ["interferon alfa", "ribavirin"], "Treatment.Drug": ["interferon alfa", "ribavirin"], "Treatment.Disorder": "NAN", "Treatment": "interferon alfa and more recently with the combination of interferon alfa plus ribavirin", "Subject.Age": "NAN", "Subject.Race": "NAN", "Treatment.Duration": "NAN", "Subject.Gender": "NAN", "Treatment.Time_elapsed": "NAN", "Treatment.Dosage": "NAN", "Subject.Population": "NAN", "Effect": "more than 20 observations of the appearance or aggravation of this granulomatosis", "Subject.Disorder": "NAN", "Treatment.Freq": "NAN"}}], "potential therapeutic event": []}