{"instruction": "You are an expert in event extraction. Please extract events from the input that conform to the schema definition. Return an empty list for events that do not exist, and return NAN for arguments that do not exist. If an argument has multiple values, please return a list. Respond in the format of a JSON string.", "schema": [{"event_type": "potential therapeutic event", "trigger": true, "arguments": ["Subject.Disorder", "Combination.Drug", "Treatment.Duration", "Treatment.Disorder", "Treatment.Route", "Subject.Age", "Subject.Population", "Effect", "Treatment.Drug", "Treatment.Time_elapsed", "Subject.Race"]}, {"event_type": "adverse event", "trigger": true, "arguments": ["Treatment.Duration", "Treatment.Time_elapsed", "Subject.Age", "Subject.Race", "Subject.Disorder", "Treatment.Drug", "Subject", "Treatment.Freq", "Treatment.Route", "Treatment", "Subject.Population", "Treatment.Disorder", "Treatment.Dosage", "Subject.Gender", "Combination.Drug", "Effect"]}], "input": "In a phase II study of hycanthone in patients with breast cancer we have recently observed severe hepatotoxicity, even at lower doses, which resulted in two drug-related deaths."}
{"potential therapeutic event": [], "adverse event": [{"trigger": "observed ", "arguments": {"Treatment.Duration": "NAN", "Treatment.Time_elapsed": "NAN", "Subject.Age": "NAN", "Subject.Race": "NAN", "Subject.Disorder": "NAN", "Treatment.Drug": "hycanthone", "Subject": "patients with breast cancer", "Treatment.Freq": "NAN", "Treatment.Route": "NAN", "Treatment": "hycanthone", "Subject.Population": "NAN", "Treatment.Disorder": "breast cancer", "Treatment.Dosage": "lower doses", "Subject.Gender": "NAN", "Combination.Drug": "NAN", "Effect": "hepatotoxicity"}}]}