{"instruction": "You are an expert in event extraction. Please extract events from the input that conform to the schema definition. Return an empty list for events that do not exist, and return NAN for arguments that do not exist. If an argument has multiple values, please return a list. Respond in the format of a JSON string.", "schema": [{"event_type": "potential therapeutic event", "trigger": true, "arguments": ["Treatment.Drug", "Treatment.Dosage", "Treatment.Route", "Subject.Age", "Treatment.Disorder", "Effect", "Combination.Drug", "Subject", "Treatment.Duration", "Subject.Disorder", "Subject.Race", "Treatment", "Subject.Gender", "Treatment.Time_elapsed"]}, {"event_type": "adverse event", "trigger": true, "arguments": ["Subject.Gender", "Treatment.Freq", "Effect", "Treatment.Disorder", "Treatment.Route", "Treatment.Time_elapsed", "Subject.Age", "Subject.Disorder", "Treatment.Duration", "Subject.Race", "Subject", "Treatment.Drug", "Treatment.Dosage", "Subject.Population", "Combination.Drug", "Treatment"]}], "input": "A macrophage activation syndrome, possibly related to methotrexate toxicity, developed in a boy with systemic juvenile rheumatoid arthritis."}
{"potential therapeutic event": [], "adverse event": [{"trigger": "developed ", "arguments": {"Subject.Gender": "boy", "Treatment.Freq": "NAN", "Effect": "macrophage activation syndrome", "Treatment.Disorder": "systemic juvenile rheumatoid arthritis", "Treatment.Route": "NAN", "Treatment.Time_elapsed": "NAN", "Subject.Age": "NAN", "Subject.Disorder": "NAN", "Treatment.Duration": "NAN", "Subject.Race": "NAN", "Subject": "a boy with systemic juvenile rheumatoid arthritis", "Treatment.Drug": "methotrexate", "Treatment.Dosage": "NAN", "Subject.Population": "NAN", "Combination.Drug": "NAN", "Treatment": "methotrexate toxicity"}}]}