{"instruction": "You are an expert in event argument extraction. Please extract event arguments and their roles from the input that conform to the schema definition, which already includes event trigger words. If an argument does not exist, return NAN or an empty dictionary. Please respond in the format of a JSON string.", "schema": [{"event_type": "potential therapeutic event", "arguments": ["Subject.Age", "Subject", "Treatment", "Subject.Disorder", "Treatment.Disorder", "Treatment.Dosage", "Treatment.Freq", "Subject.Race", "Subject.Population", "Treatment.Time_elapsed", "Treatment.Duration", "Combination.Drug", "Effect", "Subject.Gender", "Treatment.Drug"]}], "input": "Our findings suggest that significant progression of marrow reticulin fibrosis during imatinib therapy can be an indicator for a return or progression of CML and, in some patients with CML, imatinib may promote cytogenetic clonal evolution, resulting in a poor response to treatment."}
{"potential therapeutic event": []}