{"instruction": "You are an expert in event extraction. Please extract events from the input that conform to the schema definition. Return an empty list for events that do not exist, and return NAN for arguments that do not exist. If an argument has multiple values, please return a list. Respond in the format of a JSON string.", "schema": [{"event_type": "potential therapeutic event", "trigger": true, "arguments": ["Treatment.Duration", "Subject.Race", "Subject.Disorder", "Effect", "Combination.Drug", "Subject.Gender", "Treatment.Disorder", "Treatment.Drug", "Treatment", "Treatment.Freq", "Subject.Age", "Subject", "Treatment.Time_elapsed", "Subject.Population", "Treatment.Dosage"]}, {"event_type": "adverse event", "trigger": true, "arguments": ["Subject", "Treatment.Duration", "Subject.Gender", "Treatment.Route", "Treatment.Freq", "Treatment.Disorder", "Treatment", "Treatment.Dosage", "Treatment.Time_elapsed", "Treatment.Drug", "Effect", "Combination.Drug", "Subject.Population", "Subject.Race", "Subject.Disorder", "Subject.Age"]}], "input": "This complex pattern of nail and skin changes is accounted by synergy or an additive effect of chemotherapy agents on cellular proliferation of nail compartments."}
{"potential therapeutic event": [], "adverse event": [{"trigger": "synergy or an additive effect ", "arguments": {"Subject": "NAN", "Treatment.Duration": "NAN", "Subject.Gender": "NAN", "Treatment.Route": "NAN", "Treatment.Freq": "NAN", "Treatment.Disorder": "NAN", "Treatment": "chemotherapy agents", "Treatment.Dosage": "NAN", "Treatment.Time_elapsed": "NAN", "Treatment.Drug": "chemotherapy agents", "Effect": "complex pattern of nail and skin changes", "Combination.Drug": "NAN", "Subject.Population": "NAN", "Subject.Race": "NAN", "Subject.Disorder": "NAN", "Subject.Age": "NAN"}}]}