{"instruction": "You are an expert in event extraction. Please extract events from the input that conform to the schema definition. Return an empty list for events that do not exist, and return NAN for arguments that do not exist. If an argument has multiple values, please return a list. Respond in the format of a JSON string.", "schema": [{"event_type": "potential therapeutic event", "trigger": true, "arguments": ["Subject.Disorder", "Treatment.Route", "Treatment.Time_elapsed", "Treatment.Drug", "Subject.Population", "Subject.Age", "Treatment.Disorder", "Subject.Race", "Treatment.Dosage", "Treatment", "Treatment.Duration", "Subject", "Treatment.Freq", "Subject.Gender"]}, {"event_type": "adverse event", "trigger": true, "arguments": ["Treatment.Route", "Subject.Population", "Subject.Age", "Subject.Disorder", "Treatment.Drug", "Combination.Drug", "Treatment.Time_elapsed", "Treatment.Duration", "Treatment.Freq", "Subject", "Subject.Gender", "Treatment.Dosage", "Subject.Race", "Treatment.Disorder", "Treatment", "Effect"]}], "input": "Grade 3 hepatotoxicity (AST and ALT > 5 to 20 upper limit normal) or higher has been observed in as many as 1.4% of MS patients on IFN beta."}
{"potential therapeutic event": [], "adverse event": [{"trigger": "observed ", "arguments": {"Treatment.Route": "NAN", "Subject.Population": "1.4%", "Subject.Age": "NAN", "Subject.Disorder": "NAN", "Treatment.Drug": "IFN beta", "Combination.Drug": "NAN", "Treatment.Time_elapsed": "NAN", "Treatment.Duration": "NAN", "Treatment.Freq": "NAN", "Subject": "1.4% of MS patients", "Subject.Gender": "NAN", "Treatment.Dosage": "NAN", "Subject.Race": "NAN", "Treatment.Disorder": "MS", "Treatment": "IFN beta", "Effect": "Grade 3 hepatotoxicity"}}]}