{"instruction": "You are an expert in event argument extraction. Please extract event arguments and their roles from the input that conform to the schema definition, which already includes event trigger words. If an argument does not exist, return NAN or an empty dictionary. Please respond in the format of a JSON string.", "schema": [{"event_type": "adverse event", "arguments": ["Subject", "Subject.Gender", "Treatment.Drug", "Treatment.Freq", "Subject.Population", "Effect", "Treatment.Dosage", "Treatment", "Subject.Disorder", "Subject.Age", "Combination.Drug", "Treatment.Duration", "Treatment.Time_elapsed", "Treatment.Disorder"]}], "input": "It is presumed that her hyperchloremic metabolic acidosis was secondary to cholestyramine because of the similarity to pediatric reports; the rapid and lasting response to intravenous sodium bicarbonate; the absence of another etiology; normal serum potassium, chloride and bicarbonate despite continued spironolactone therapy after recovery."}
{"adverse event": [{"Subject": "NAN", "Subject.Gender": "NAN", "Treatment.Drug": "cholestyramine", "Treatment.Freq": "NAN", "Subject.Population": "NAN", "Effect": "hyperchloremic metabolic acidosis", "Treatment.Dosage": "NAN", "Treatment": "cholestyramine", "Subject.Disorder": "NAN", "Subject.Age": "NAN", "Combination.Drug": "NAN", "Treatment.Duration": "NAN", "Treatment.Time_elapsed": "NAN", "Treatment.Disorder": "NAN"}]}