{"instruction": "You are an expert in event argument extraction. Please extract event arguments and their roles from the input that conform to the schema definition, which already includes event trigger words. If an argument does not exist, return NAN or an empty dictionary. Please respond in the format of a JSON string.", "schema": [{"event_type": "potential therapeutic event", "arguments": ["Combination.Drug", "Effect", "Subject", "Treatment.Drug", "Treatment", "Treatment.Freq", "Treatment.Route", "Treatment.Dosage", "Subject.Race", "Subject.Gender", "Subject.Population", "Treatment.Time_elapsed", "Treatment.Disorder", "Subject.Disorder", "Subject.Age"]}], "input": "Treatment was begun with amphotericin B-deoxycholate but renal toxicity signs led to its substitution by fluconazole."}
{"potential therapeutic event": []}