{"instruction": "You are an expert in event argument extraction. Please extract event arguments and their roles from the input that conform to the schema definition, which already includes event trigger words. If an argument does not exist, return NAN or an empty dictionary. Please respond in the format of a JSON string.", "schema": [{"event_type": "adverse event", "arguments": ["Effect", "Combination.Drug", "Treatment.Time_elapsed", "Treatment.Duration", "Subject.Disorder", "Subject.Age", "Subject", "Subject.Gender", "Subject.Race", "Treatment.Drug", "Treatment.Disorder", "Treatment.Route", "Treatment", "Treatment.Freq", "Treatment.Dosage"]}], "input": "Based on our previous demonstration that quinine could be used clinically to reverse P-glycoprotein-mediated resistance, we designed a multicenter, randomized trial aiming to determine whether quinine would improve the survival of adult patients (15-60 years old) with de novo acute myelogenous leukemia (AML)."}
{"adverse event": []}