{"instruction": "You are an expert in event argument extraction. Please extract event arguments and their roles from the input that conform to the schema definition, which already includes event trigger words. If an argument does not exist, return NAN or an empty dictionary. Please respond in the format of a JSON string.", "schema": [{"event_type": "adverse event", "arguments": ["Treatment.Freq", "Subject.Gender", "Combination.Drug", "Treatment.Time_elapsed", "Subject.Age", "Subject.Race", "Treatment.Dosage", "Subject", "Treatment.Drug", "Treatment.Disorder", "Treatment.Route", "Treatment", "Subject.Disorder", "Treatment.Duration"]}], "input": "In this case, 5-FU increased PHT, which in turn may have increased the PB concentration, suggesting that when fluoropyrimidine antitumor agents are administered to patients receiving PHT in combination with other drugs, some measures should be taken in consideration of secondary effects of antitumor agents on other drugs that may possibly interact with PHT, including frequent monitoring of blood drug concentration."}
{"adverse event": [{"Treatment.Freq": "NAN", "Subject.Gender": "NAN", "Combination.Drug": ["5-FU", "PHT"], "Treatment.Time_elapsed": "NAN", "Subject.Age": "NAN", "Subject.Race": "NAN", "Treatment.Dosage": "NAN", "Subject": "patients", "Treatment.Drug": ["5-FU", "PHT"], "Treatment.Disorder": "NAN", "Treatment.Route": "NAN", "Treatment": "5-FU increased PHT, which in turn may have increased the PB concentration", "Subject.Disorder": "NAN", "Treatment.Duration": "NAN"}]}