{"instruction": "You are an expert in event argument extraction. Please extract event arguments and their roles from the input that conform to the schema definition, which already includes event trigger words. If an argument does not exist, return NAN or an empty dictionary. Please respond in the format of a JSON string.", "schema": [{"event_type": "adverse event", "arguments": ["Combination.Drug", "Subject.Race", "Treatment.Disorder", "Treatment", "Subject.Disorder", "Treatment.Time_elapsed", "Subject.Age", "Treatment.Duration", "Treatment.Route", "Treatment.Dosage", "Subject.Population", "Treatment.Freq", "Effect", "Subject.Gender", "Treatment.Drug"]}], "input": "This fourth type of cutaneous minocycline hyperpigmentation may be a variant of Type I, but based on clinical, pathological and microanalytical differences, appears to be a new entity."}
{"adverse event": [{"Combination.Drug": "NAN", "Subject.Race": "NAN", "Treatment.Disorder": "NAN", "Treatment": "minocycline", "Subject.Disorder": "NAN", "Treatment.Time_elapsed": "NAN", "Subject.Age": "NAN", "Treatment.Duration": "NAN", "Treatment.Route": "NAN", "Treatment.Dosage": "NAN", "Subject.Population": "NAN", "Treatment.Freq": "NAN", "Effect": "hyperpigmentation", "Subject.Gender": "NAN", "Treatment.Drug": "minocycline"}]}