{"instruction": "You are an expert in event extraction. Please extract events from the input that conform to the schema definition. Return an empty list for events that do not exist, and return NAN for arguments that do not exist. If an argument has multiple values, please return a list. Respond in the format of a JSON string.", "schema": [{"event_type": "adverse event", "trigger": true, "arguments": ["Subject.Age", "Effect", "Combination.Drug", "Subject", "Treatment.Dosage", "Treatment.Route", "Subject.Disorder", "Subject.Race", "Treatment.Disorder", "Treatment", "Treatment.Drug", "Treatment.Time_elapsed", "Subject.Gender", "Treatment.Duration", "Treatment.Freq", "Subject.Population"]}, {"event_type": "potential therapeutic event", "trigger": true, "arguments": ["Subject.Race", "Treatment.Dosage", "Treatment.Time_elapsed", "Subject.Disorder", "Subject.Age", "Subject", "Treatment.Duration", "Treatment.Route", "Treatment.Disorder", "Treatment", "Combination.Drug", "Treatment.Drug", "Subject.Population"]}], "input": "Hypothyroidism, occurring in up to 11 percent of patients treated with amiodarone, can also alter drug metabolism and sensitize the central nervous system, thus increasing the potential for toxicity."}
{"adverse event": [{"trigger": "occurring ", "arguments": {"Subject.Age": "NAN", "Effect": "Hypothyroidism", "Combination.Drug": "NAN", "Subject": "11 percent of patients", "Treatment.Dosage": "NAN", "Treatment.Route": "NAN", "Subject.Disorder": "NAN", "Subject.Race": "NAN", "Treatment.Disorder": "NAN", "Treatment": "amiodarone", "Treatment.Drug": "amiodarone", "Treatment.Time_elapsed": "NAN", "Subject.Gender": "NAN", "Treatment.Duration": "NAN", "Treatment.Freq": "NAN", "Subject.Population": "11 percent"}}], "potential therapeutic event": []}