{"instruction": "You are an expert in named entity recognition. Please extract entities that match the schema definition from the input. Return an empty list if the entity type does not exist. Please respond in the format of a JSON string.", "schema": ["GENE"], "input": "We used stored plasma samples from 409 patients in the National Institute of Neurological Diseases and Stroke ( NINDS ) tissue plasminogen activator ( t - PA ) Stroke Trial to examine the relationship between an apolipoprotein ( Apo ) E2 or an Apo E4 phenotype and a favorable outcome 3 months after stroke , the risk of intracerebral hemorrhage , and the response to intravenous t - PA therapy ."}
{"GENE": ["tissue plasminogen activator", "t - PA", "apolipoprotein ( Apo ) E2", "Apo E4"]}