{"instruction": "You are an expert in relationship extraction. Please extract relationship triples that match the schema definition from the input. Return an empty list for relationships that do not exist. Please respond in the format of a JSON string.", "schema": ["adverse effect"], "input": "Attempts were made to stop and then restart the theophylline therapy at progressively lower doses ; however , with each attempt , the patient 's reaction to the drug became more toxic , with serum theophylline levels ranging between 99.9 and 149.9 micromol / L ( 18 and 27 microg / mL ) ."}
{"adverse effect": [{"subject": "reaction to the drug became more toxic", "object": "theophylline"}]}