{"instruction": "You are an expert in event argument extraction. Please extract event arguments and their roles from the input that conform to the schema definition, which already includes event trigger words. If an argument does not exist, return NAN or an empty dictionary. Please respond in the format of a JSON string.", "schema": [{"event_type": "adverse event", "arguments": ["Combination.Drug", "Subject.Disorder", "Subject", "Treatment.Dosage", "Treatment.Route", "Effect", "Treatment", "Treatment.Duration", "Treatment.Freq", "Treatment.Drug", "Subject.Gender", "Subject.Age", "Subject.Population", "Treatment.Disorder", "Treatment.Time_elapsed"]}], "input": "Agranulocytosis is a rare adverse effect associated with prolonged vancomycin therapy, and is potentially serious, especially in end stage renal disease (ESRD) patients."}
{"adverse event": [{"Combination.Drug": "NAN", "Subject.Disorder": "NAN", "Subject": "end stage renal disease (ESRD) patients", "Treatment.Dosage": "NAN", "Treatment.Route": "NAN", "Effect": "Agranulocytosis", "Treatment": "prolonged vancomycin therapy", "Treatment.Duration": "prolonged", "Treatment.Freq": "NAN", "Treatment.Drug": "vancomycin", "Subject.Gender": "NAN", "Subject.Age": "NAN", "Subject.Population": "NAN", "Treatment.Disorder": "end stage renal disease (ESRD)", "Treatment.Time_elapsed": "NAN"}]}