{"instruction": "You are an expert in event argument extraction. Please extract event arguments and their roles from the input that conform to the schema definition, which already includes event trigger words. If an argument does not exist, return NAN or an empty dictionary. Please respond in the format of a JSON string.", "schema": [{"event_type": "potential therapeutic event", "arguments": ["Subject", "Treatment.Duration", "Combination.Drug", "Treatment.Freq", "Subject.Disorder", "Treatment.Dosage", "Treatment.Drug", "Subject.Age", "Effect", "Subject.Gender", "Treatment.Route", "Treatment", "Subject.Race", "Treatment.Disorder", "Subject.Population"]}], "input": "Hypothyroidism, occurring in up to 11 percent of patients treated with amiodarone, can also alter drug metabolism and sensitize the central nervous system, thus increasing the potential for toxicity."}
{"potential therapeutic event": []}