{"instruction": "You are an expert in event extraction. Please extract events from the input that conform to the schema definition. Return an empty list for events that do not exist, and return NAN for arguments that do not exist. If an argument has multiple values, please return a list. Respond in the format of a JSON string.", "schema": [{"event_type": "potential therapeutic event", "trigger": true, "arguments": ["Treatment.Drug", "Combination.Drug", "Effect", "Treatment.Disorder", "Treatment.Dosage", "Subject", "Subject.Disorder", "Subject.Gender", "Treatment.Duration", "Treatment.Time_elapsed", "Subject.Population", "Treatment.Freq", "Treatment.Route", "Subject.Age", "Treatment", "Subject.Race"]}, {"event_type": "adverse event", "trigger": true, "arguments": ["Subject", "Subject.Population", "Treatment.Freq", "Effect", "Combination.Drug", "Treatment.Drug", "Treatment.Duration", "Subject.Disorder", "Treatment.Route", "Treatment.Dosage", "Treatment", "Subject.Gender", "Treatment.Disorder"]}], "input": "Intravenous fluconazole 400 mg, followed by 100 mg every 24 hours according to impaired renal function, was immediately started; to avoid further nephrotoxicity, immunosuppressant therapy was switched from cyclosporine plus mycophenolate mofetil to oral everolimus 0.75 mg every 12 hours."}
{"potential therapeutic event": [{"trigger": "avoid ", "arguments": {"Treatment.Drug": ["cyclosporine", "everolimus", "mycophenolate mofetil", "fluconazole"], "Combination.Drug": ["fluconazole", "everolimus", "cyclosporine", "mycophenolate mofetil"], "Effect": "NAN", "Treatment.Disorder": "nephrotoxicity", "Treatment.Dosage": ["0.75 mg every 12 hours", "400 mg, followed by 100 mg every 24 hours"], "Subject": "NAN", "Subject.Disorder": "NAN", "Subject.Gender": "NAN", "Treatment.Duration": "NAN", "Treatment.Time_elapsed": "NAN", "Subject.Population": "NAN", "Treatment.Freq": "NAN", "Treatment.Route": ["oral", "Intravenous"], "Subject.Age": "NAN", "Treatment": ["Intravenous fluconazole 400 mg, followed by 100 mg every 24 hours", "immunosuppressant therapy was switched from cyclosporine plus mycophenolate mofetil to oral everolimus 0.75 mg every 12 hours"], "Subject.Race": "NAN"}}], "adverse event": []}