{"instruction": "You are an expert in event extraction. Please extract events from the input that conform to the schema definition. Return an empty list for events that do not exist, and return NAN for arguments that do not exist. If an argument has multiple values, please return a list. Respond in the format of a JSON string.", "schema": [{"event_type": "potential therapeutic event", "trigger": true, "arguments": ["Treatment.Freq", "Subject.Disorder", "Treatment.Dosage", "Subject.Age", "Treatment.Route", "Subject.Gender", "Effect", "Treatment", "Subject.Population", "Treatment.Duration", "Treatment.Disorder", "Treatment.Drug", "Combination.Drug", "Treatment.Time_elapsed", "Subject.Race", "Subject"]}, {"event_type": "adverse event", "trigger": true, "arguments": ["Treatment.Freq", "Treatment", "Treatment.Drug", "Subject.Race", "Treatment.Disorder", "Treatment.Route", "Treatment.Time_elapsed", "Treatment.Duration", "Subject.Disorder", "Subject.Gender", "Combination.Drug", "Subject", "Subject.Age", "Treatment.Dosage", "Effect", "Subject.Population"]}], "input": "Based on our previous demonstration that quinine could be used clinically to reverse P-glycoprotein-mediated resistance, we designed a multicenter, randomized trial aiming to determine whether quinine would improve the survival of adult patients (15-60 years old) with de novo acute myelogenous leukemia (AML)."}
{"potential therapeutic event": [{"trigger": "improve ", "arguments": {"Treatment.Freq": "NAN", "Subject.Disorder": "NAN", "Treatment.Dosage": "NAN", "Subject.Age": ["adult", "15-60 years old"], "Treatment.Route": "NAN", "Subject.Gender": "NAN", "Effect": "reverse P-glycoprotein-mediated resistance", "Treatment": "quinine", "Subject.Population": "NAN", "Treatment.Duration": "NAN", "Treatment.Disorder": "de novo acute myelogenous leukemia (AML)", "Treatment.Drug": "quinine", "Combination.Drug": "NAN", "Treatment.Time_elapsed": "NAN", "Subject.Race": "NAN", "Subject": "adult patients (15-60 years old)"}}], "adverse event": []}