{"instruction": "You are an expert in event extraction. Please extract events from the input that conform to the schema definition. Return an empty list for events that do not exist, and return NAN for arguments that do not exist. If an argument has multiple values, please return a list. Respond in the format of a JSON string.", "schema": [{"event_type": "potential therapeutic event", "trigger": true, "arguments": ["Subject.Disorder", "Combination.Drug", "Treatment.Route", "Treatment.Disorder", "Treatment", "Treatment.Freq", "Subject.Age", "Subject.Population", "Subject", "Treatment.Duration", "Treatment.Dosage"]}, {"event_type": "adverse event", "trigger": true, "arguments": ["Subject.Population", "Treatment.Freq", "Treatment.Route", "Effect", "Subject", "Treatment.Disorder", "Treatment.Duration", "Treatment.Time_elapsed", "Subject.Gender", "Subject.Race", "Treatment", "Subject.Age", "Treatment.Drug", "Subject.Disorder"]}], "input": "Discontinuation of methicillin therapy and appropriate antibiotic treatment of endocarditis led to clinical improvement, emphasizing the need to promptly discontinue potential nephrotoxic agents when abnormalities in renal function appear."}
{"potential therapeutic event": [], "adverse event": [{"trigger": "appear.", "arguments": {"Subject.Population": "NAN", "Treatment.Freq": "NAN", "Treatment.Route": "NAN", "Effect": "abnormalities in renal function", "Subject": "NAN", "Treatment.Disorder": "endocarditis", "Treatment.Duration": "NAN", "Treatment.Time_elapsed": "NAN", "Subject.Gender": "NAN", "Subject.Race": "NAN", "Treatment": "methicillin", "Subject.Age": "NAN", "Treatment.Drug": ["antibiotic", "nephrotoxic agents", "methicillin"], "Subject.Disorder": "NAN"}}]}