{"instruction": "You are an expert in event extraction. Please extract events from the input that conform to the schema definition. Return an empty list for events that do not exist, and return NAN for arguments that do not exist. If an argument has multiple values, please return a list. Respond in the format of a JSON string.", "schema": [{"event_type": "potential therapeutic event", "trigger": true, "arguments": ["Treatment.Drug", "Effect", "Treatment.Time_elapsed", "Treatment.Freq", "Subject.Disorder", "Combination.Drug", "Subject.Gender", "Treatment", "Subject.Race", "Subject.Population", "Treatment.Dosage", "Treatment.Disorder", "Subject.Age", "Subject"]}, {"event_type": "adverse event", "trigger": true, "arguments": ["Treatment.Route", "Subject.Population", "Treatment.Freq", "Subject", "Subject.Age", "Subject.Disorder", "Subject.Race", "Treatment", "Treatment.Time_elapsed", "Treatment.Dosage", "Effect", "Treatment.Disorder", "Treatment.Duration", "Treatment.Drug", "Subject.Gender", "Combination.Drug"]}], "input": "Because of further progression combination treatment of bevacizumab and irinotecan was started and again no liver toxicity was observed."}
{"potential therapeutic event": [], "adverse event": [{"trigger": "observed.", "arguments": {"Treatment.Route": "NAN", "Subject.Population": "NAN", "Treatment.Freq": "NAN", "Subject": "NAN", "Subject.Age": "NAN", "Subject.Disorder": "NAN", "Subject.Race": "NAN", "Treatment": "bevacizumab and irinotecan", "Treatment.Time_elapsed": "NAN", "Treatment.Dosage": "NAN", "Effect": "liver toxicity", "Treatment.Disorder": "NAN", "Treatment.Duration": "NAN", "Treatment.Drug": ["irinotecan", "bevacizumab"], "Subject.Gender": "NAN", "Combination.Drug": ["irinotecan", "bevacizumab"]}}]}