{"instruction": "You are an expert in event argument extraction. Please extract event arguments and their roles from the input that conform to the schema definition, which already includes event trigger words. If an argument does not exist, return NAN or an empty dictionary. Please respond in the format of a JSON string.", "schema": [{"event_type": "adverse event", "arguments": ["Treatment", "Treatment.Freq", "Treatment.Dosage", "Combination.Drug", "Effect", "Treatment.Disorder", "Treatment.Time_elapsed", "Subject.Gender", "Subject", "Treatment.Route", "Subject.Disorder", "Subject.Age", "Treatment.Duration", "Subject.Race", "Treatment.Drug"]}], "input": "Nine eyes from 6 patients, 74 years to 90 years of age, referred by ophthalmologists for repair of cicatricial entropion after at least 2 years of twice-a-day application of dipivefrin."}
{"adverse event": [{"Treatment": "at least 2 years of twice-a-day application of dipivefrin", "Treatment.Freq": "twice-a-day", "Treatment.Dosage": "NAN", "Combination.Drug": "NAN", "Effect": "cicatricial entropion", "Treatment.Disorder": "NAN", "Treatment.Time_elapsed": "NAN", "Subject.Gender": "NAN", "Subject": "Nine eyes from 6 patients, 74 years to 90 years of age", "Treatment.Route": "NAN", "Subject.Disorder": "NAN", "Subject.Age": "74 years to 90 years", "Treatment.Duration": "2 years", "Subject.Race": "NAN", "Treatment.Drug": "dipivefrin"}]}