{"instruction": "You are an expert in event extraction. Please extract events from the input that conform to the schema definition. Return an empty list for events that do not exist, and return NAN for arguments that do not exist. If an argument has multiple values, please return a list. Respond in the format of a JSON string.", "schema": [{"event_type": "potential therapeutic event", "trigger": true, "arguments": ["Subject.Gender", "Treatment.Duration", "Subject.Disorder", "Treatment.Drug", "Treatment.Route", "Treatment.Time_elapsed", "Effect", "Treatment", "Treatment.Dosage", "Treatment.Freq", "Subject", "Combination.Drug"]}, {"event_type": "adverse event", "trigger": true, "arguments": ["Treatment.Dosage", "Subject.Age", "Treatment.Drug", "Treatment", "Subject.Population", "Subject.Gender", "Treatment.Duration", "Treatment.Route", "Effect", "Combination.Drug", "Subject.Disorder", "Treatment.Freq", "Treatment.Disorder", "Subject", "Treatment.Time_elapsed", "Subject.Race"]}], "input": "Reinstitution of penicillamine treatment caused a recurrence thus proving a causal relationship between penicillamine and the described nail-changes."}
{"potential therapeutic event": [], "adverse event": [{"trigger": "causal relationship ", "arguments": {"Treatment.Dosage": "NAN", "Subject.Age": "NAN", "Treatment.Drug": "penicillamine", "Treatment": "penicillamine", "Subject.Population": "NAN", "Subject.Gender": "NAN", "Treatment.Duration": "NAN", "Treatment.Route": "NAN", "Effect": "nail-changes", "Combination.Drug": "NAN", "Subject.Disorder": "NAN", "Treatment.Freq": "NAN", "Treatment.Disorder": "NAN", "Subject": "NAN", "Treatment.Time_elapsed": "NAN", "Subject.Race": "NAN"}}]}