{"instruction": "You are an expert in event extraction. Please extract events from the input that conform to the schema definition. Return an empty list for events that do not exist, and return NAN for arguments that do not exist. If an argument has multiple values, please return a list. Respond in the format of a JSON string.", "schema": [{"event_type": "adverse event", "trigger": true, "arguments": ["Combination.Drug", "Subject", "Subject.Gender", "Subject.Race", "Effect", "Treatment.Time_elapsed", "Treatment.Dosage", "Treatment.Freq", "Subject.Population", "Treatment.Disorder", "Treatment.Duration", "Treatment.Route", "Treatment", "Subject.Age", "Treatment.Drug", "Subject.Disorder"]}, {"event_type": "potential therapeutic event", "trigger": true, "arguments": ["Effect", "Combination.Drug", "Treatment.Route", "Subject.Population", "Subject.Disorder", "Treatment", "Treatment.Dosage", "Subject.Race", "Treatment.Freq", "Subject.Age", "Treatment.Disorder", "Treatment.Duration", "Treatment.Time_elapsed", "Subject.Gender", "Subject"]}], "input": "The human immunodeficiency virus protease inhibitor ritonavir is a potent inhibitor of the cytochrome P450 3A4 enzyme, and ritonavir's concomitant administration with the substrates of this enzyme may lead to dangerous drug interactions."}
{"adverse event": [{"trigger": "lead ", "arguments": {"Combination.Drug": ["ritonavir", "substrates of this enzyme"], "Subject": "NAN", "Subject.Gender": "NAN", "Subject.Race": "NAN", "Effect": "drug interactions", "Treatment.Time_elapsed": "NAN", "Treatment.Dosage": "NAN", "Treatment.Freq": "NAN", "Subject.Population": "NAN", "Treatment.Disorder": "NAN", "Treatment.Duration": "NAN", "Treatment.Route": "NAN", "Treatment": "ritonavir's concomitant administration with the substrates of this enzyme", "Subject.Age": "NAN", "Treatment.Drug": ["ritonavir", "substrates of this enzyme"], "Subject.Disorder": "NAN"}}], "potential therapeutic event": []}