{"instruction": "You are an expert in event argument extraction. Please extract event arguments and their roles from the input that conform to the schema definition, which already includes event trigger words. If an argument does not exist, return NAN or an empty dictionary. Please respond in the format of a JSON string.", "schema": [{"event_type": "adverse event", "arguments": ["Subject.Age", "Subject.Race", "Treatment.Freq", "Combination.Drug", "Subject", "Treatment.Time_elapsed", "Treatment.Dosage", "Subject.Disorder", "Treatment.Disorder", "Subject.Population", "Effect", "Treatment", "Treatment.Duration", "Subject.Gender"]}], "input": "However, in the mid-to-late 1980s, a series of letters to the editor and case reports announced an association between tamoxifen therapy in women with breast cancer and the development of endometrial carcinoma."}
{"adverse event": [{"Subject.Age": "NAN", "Subject.Race": "NAN", "Treatment.Freq": "NAN", "Combination.Drug": "NAN", "Subject": "women with breast cancer", "Treatment.Time_elapsed": "NAN", "Treatment.Dosage": "NAN", "Subject.Disorder": "NAN", "Treatment.Disorder": "breast cancer", "Subject.Population": "NAN", "Effect": "endometrial carcinoma", "Treatment": "tamoxifen", "Treatment.Duration": "NAN", "Subject.Gender": "women"}]}