{"instruction": "You are an expert in relationship extraction. Please extract relationship triples that match the schema definition from the input. Return an empty list for relationships that do not exist. Please respond in the format of a JSON string.", "schema": ["adverse effect"], "input": "We review the literature on previously reported cases of cutaneous necrosis after injection of standard interferon alfa or pegylated interferon alfa-2b and discuss the different pathophysiologic mechanisms that might be involved ."}
{"adverse effect": [{"subject": "cutaneous necrosis", "object": "interferon alfa"}, {"subject": "cutaneous necrosis", "object": "pegylated interferon alfa-2b"}]}