{"instruction": "You are an expert in event argument extraction. Please extract event arguments and their roles from the input that conform to the schema definition, which already includes event trigger words. If an argument does not exist, return NAN or an empty dictionary. Please respond in the format of a JSON string.", "schema": [{"event_type": "adverse event", "arguments": ["Subject.Population", "Subject", "Treatment.Dosage", "Subject.Gender", "Subject.Disorder", "Treatment.Duration", "Combination.Drug", "Subject.Age", "Effect", "Treatment.Time_elapsed", "Treatment", "Subject.Race", "Treatment.Drug", "Treatment.Disorder", "Treatment.Route", "Treatment.Freq"]}], "input": "We believe the most likely cause was hepatic inhibition of the CYP3A4 hepatic isoenzyme by fusidic acid resulting in an acute severe rise in plasma simvastatin level and extensive myocellular damage."}
{"adverse event": [{"Subject.Population": "NAN", "Subject": "NAN", "Treatment.Dosage": "NAN", "Subject.Gender": "NAN", "Subject.Disorder": "NAN", "Treatment.Duration": "NAN", "Combination.Drug": "NAN", "Subject.Age": "NAN", "Effect": "an acute severe rise in plasma simvastatin level and extensive myocellular damage", "Treatment.Time_elapsed": "NAN", "Treatment": "fusidic acid", "Subject.Race": "NAN", "Treatment.Drug": "fusidic acid", "Treatment.Disorder": "NAN", "Treatment.Route": "NAN", "Treatment.Freq": "NAN"}]}