{"instruction": "You are an expert in event argument extraction. Please extract event arguments and their roles from the input that conform to the schema definition, which already includes event trigger words. If an argument does not exist, return NAN or an empty dictionary. Please respond in the format of a JSON string.", "schema": [{"event_type": "potential therapeutic event", "arguments": ["Treatment.Duration", "Treatment.Freq", "Treatment.Disorder", "Combination.Drug", "Effect", "Treatment.Dosage", "Treatment", "Subject", "Treatment.Time_elapsed", "Subject.Disorder", "Treatment.Route", "Subject.Population", "Treatment.Drug"]}], "input": "The successful development and implementation of this protocol will have impact on patients who have anaphylactic reactions to MTX but require this medication for specific diseases."}
{"potential therapeutic event": []}