{"instruction": "You are an expert in event argument extraction. Please extract event arguments and their roles from the input that conform to the schema definition, which already includes event trigger words. If an argument does not exist, return NAN or an empty dictionary. Please respond in the format of a JSON string.", "schema": [{"event_type": "adverse event", "arguments": ["Treatment.Freq", "Treatment", "Treatment.Drug", "Subject.Population", "Effect", "Treatment.Dosage", "Subject.Gender", "Treatment.Duration", "Treatment.Time_elapsed", "Subject.Race", "Subject", "Combination.Drug", "Subject.Disorder", "Treatment.Disorder", "Subject.Age"]}], "input": "With the use of optical coherence tomography (OCT), two patients with IFN-associated retinopathy who had developed macular edema and reduced visual acuity during the clinical course of IFN therapy were observed."}
{"adverse event": [{"Treatment.Freq": "NAN", "Treatment": "IFN", "Treatment.Drug": "IFN", "Subject.Population": "NAN", "Effect": ["retinopathy", "macular edema and reduced visual acuity"], "Treatment.Dosage": "NAN", "Subject.Gender": "NAN", "Treatment.Duration": "NAN", "Treatment.Time_elapsed": "NAN", "Subject.Race": "NAN", "Subject": "NAN", "Combination.Drug": "NAN", "Subject.Disorder": "NAN", "Treatment.Disorder": "NAN", "Subject.Age": "NAN"}]}