{"instruction": "You are an expert in named entity recognition. Please extract entities that match the schema definition from the input. Return an empty list if the entity type does not exist. Please respond in the format of a JSON string.", "schema": ["Disease"], "input": "Nine different germ - line mutations in the BRCA1 breast and ovarian cancer susceptibility gene were identified in 15 of 47 kindreds from southern Sweden , by use of SSCP and heteroduplex analysis of all exons and flanking intron region and by a protein - truncation test for exon 11 , followed by direct sequencing ."}
{"Disease": ["breast and ovarian cancer"]}