{"instruction": "You are an expert in event argument extraction. Please extract event arguments and their roles from the input that conform to the schema definition, which already includes event trigger words. If an argument does not exist, return NAN or an empty dictionary. Please respond in the format of a JSON string.", "schema": [{"event_type": "adverse event", "arguments": ["Subject.Gender", "Treatment", "Treatment.Time_elapsed", "Subject", "Effect", "Combination.Drug", "Subject.Disorder", "Treatment.Disorder", "Treatment.Drug", "Subject.Age", "Subject.Population", "Treatment.Freq", "Treatment.Route"]}], "input": "Intravenous fluconazole 400 mg, followed by 100 mg every 24 hours according to impaired renal function, was immediately started; to avoid further nephrotoxicity, immunosuppressant therapy was switched from cyclosporine plus mycophenolate mofetil to oral everolimus 0.75 mg every 12 hours."}
{"adverse event": []}