{"instruction": "You are an expert in event extraction. Please extract events from the input that conform to the schema definition. Return an empty list for events that do not exist, and return NAN for arguments that do not exist. If an argument has multiple values, please return a list. Respond in the format of a JSON string.", "schema": [{"event_type": "potential therapeutic event", "trigger": true, "arguments": ["Treatment.Duration", "Treatment.Route", "Treatment.Disorder", "Effect", "Subject.Race", "Treatment.Drug", "Treatment.Freq", "Subject.Age", "Subject", "Subject.Gender", "Treatment.Dosage", "Subject.Population", "Subject.Disorder", "Treatment.Time_elapsed", "Combination.Drug", "Treatment"]}, {"event_type": "adverse event", "trigger": true, "arguments": ["Treatment.Route", "Subject.Race", "Treatment.Time_elapsed", "Treatment.Freq", "Subject.Gender", "Effect", "Treatment.Duration", "Subject", "Treatment.Dosage", "Treatment.Disorder", "Subject.Disorder", "Combination.Drug", "Subject.Population", "Subject.Age", "Treatment.Drug", "Treatment"]}], "input": "We describe two patients with rheumatoid factor-positive, polyarticular-onset juvenile rheumatoid arthritis in whom accelerated nodulosis developed during methotrexate therapy."}
{"potential therapeutic event": [], "adverse event": [{"trigger": "developed ", "arguments": {"Treatment.Route": "NAN", "Subject.Race": "NAN", "Treatment.Time_elapsed": "NAN", "Treatment.Freq": "NAN", "Subject.Gender": "NAN", "Effect": "accelerated nodulosis", "Treatment.Duration": "NAN", "Subject": "two patients with rheumatoid factor-positive, polyarticular-onset juvenile rheumatoid arthritis", "Treatment.Dosage": "NAN", "Treatment.Disorder": "rheumatoid factor-positive, polyarticular-onset juvenile rheumatoid arthritis", "Subject.Disorder": "NAN", "Combination.Drug": "NAN", "Subject.Population": "two", "Subject.Age": "NAN", "Treatment.Drug": "methotrexate", "Treatment": "methotrexate therapy"}}]}