{"instruction": "You are an expert in event extraction. Please extract events from the input that conform to the schema definition. Return an empty list for events that do not exist, and return NAN for arguments that do not exist. If an argument has multiple values, please return a list. Respond in the format of a JSON string.", "schema": [{"event_type": "adverse event", "trigger": true, "arguments": ["Treatment.Drug", "Subject.Population", "Combination.Drug", "Effect", "Subject.Disorder", "Treatment.Freq", "Treatment.Time_elapsed", "Subject.Age", "Subject", "Treatment.Route", "Subject.Gender", "Treatment.Dosage", "Treatment"]}, {"event_type": "potential therapeutic event", "trigger": true, "arguments": ["Subject.Population", "Treatment.Duration", "Treatment.Time_elapsed", "Effect", "Subject.Gender", "Treatment.Freq", "Treatment", "Subject.Race", "Treatment.Disorder", "Treatment.Route", "Subject.Disorder"]}], "input": "In this case, 5-FU increased PHT, which in turn may have increased the PB concentration, suggesting that when fluoropyrimidine antitumor agents are administered to patients receiving PHT in combination with other drugs, some measures should be taken in consideration of secondary effects of antitumor agents on other drugs that may possibly interact with PHT, including frequent monitoring of blood drug concentration."}
{"adverse event": [{"trigger": "interact ", "arguments": {"Treatment.Drug": ["PHT", "5-FU"], "Subject.Population": "NAN", "Combination.Drug": ["PHT", "5-FU"], "Effect": "secondary effects of antitumor agents on other drugs", "Subject.Disorder": "NAN", "Treatment.Freq": "NAN", "Treatment.Time_elapsed": "NAN", "Subject.Age": "NAN", "Subject": "patients", "Treatment.Route": "NAN", "Subject.Gender": "NAN", "Treatment.Dosage": "NAN", "Treatment": "5-FU increased PHT, which in turn may have increased the PB concentration"}}], "potential therapeutic event": []}