{"instruction": "You are an expert in named entity recognition. Please extract entities that match the schema definition from the input. Return an empty list if the entity type does not exist. Please respond in the format of a JSON string.", "schema": ["GENE"], "input": "Metformin plasma concentrations remained unchanged except for patients transferred from 1 . 5 to 2 . 0 g daily to 850 mg twice daily ; in these patients plasma concentrations increased from 1 . 83 + / - 0 . 87 to 2 . 50 + / - 0 . 89 micrograms / l ( p less than 0 . 01 ) ."}
{"GENE": []}