{"instruction": "You are an expert in event extraction. Please extract events from the input that conform to the schema definition. Return an empty list for events that do not exist, and return NAN for arguments that do not exist. If an argument has multiple values, please return a list. Respond in the format of a JSON string.", "schema": [{"event_type": "potential therapeutic event", "trigger": true, "arguments": ["Treatment", "Subject.Disorder", "Subject", "Combination.Drug", "Subject.Gender", "Treatment.Drug", "Treatment.Duration", "Subject.Age", "Treatment.Time_elapsed", "Treatment.Disorder", "Effect"]}, {"event_type": "adverse event", "trigger": true, "arguments": ["Treatment.Freq", "Treatment", "Treatment.Dosage", "Subject.Population", "Subject.Age", "Combination.Drug", "Treatment.Route", "Effect", "Treatment.Drug", "Treatment.Duration", "Treatment.Time_elapsed", "Subject.Disorder", "Subject.Gender", "Subject.Race", "Subject", "Treatment.Disorder"]}], "input": "Although use of the Naranjo adverse reaction probability scale indicated a probable relationship (score of 6) between the patient's development of methotrexate toxicity and omeprazole use, we believe this was a drug-drug interaction case consistent with previous reports in the literature."}
{"potential therapeutic event": [], "adverse event": [{"trigger": "relationship ", "arguments": {"Treatment.Freq": "NAN", "Treatment": ["and omeprazole use", "methotrexate"], "Treatment.Dosage": "NAN", "Subject.Population": "NAN", "Subject.Age": "NAN", "Combination.Drug": ["omeprazole", "methotrexate"], "Treatment.Route": "NAN", "Effect": "methotrexate toxicity", "Treatment.Drug": ["omeprazole", "methotrexate"], "Treatment.Duration": "NAN", "Treatment.Time_elapsed": "NAN", "Subject.Disorder": "NAN", "Subject.Gender": "NAN", "Subject.Race": "NAN", "Subject": "the patient", "Treatment.Disorder": "NAN"}}]}