{"instruction": "You are an expert in event extraction. Please extract events from the input that conform to the schema definition. Return an empty list for events that do not exist, and return NAN for arguments that do not exist. If an argument has multiple values, please return a list. Respond in the format of a JSON string.", "schema": [{"event_type": "adverse event", "trigger": true, "arguments": ["Subject.Population", "Treatment.Disorder", "Subject.Age", "Treatment.Time_elapsed", "Subject.Disorder", "Effect", "Combination.Drug", "Treatment.Freq", "Treatment.Dosage", "Treatment.Duration", "Subject.Gender", "Treatment", "Treatment.Route", "Subject.Race", "Treatment.Drug", "Subject"]}, {"event_type": "potential therapeutic event", "trigger": true, "arguments": ["Combination.Drug", "Subject.Population", "Subject.Gender", "Subject.Disorder", "Treatment.Drug", "Treatment.Dosage", "Subject", "Treatment.Route", "Treatment.Freq", "Treatment.Disorder", "Subject.Race"]}], "input": "Thalidomide has proven activity in refractory multiple myeloma (MM), and although single-agent thalidomide has minimal prothrombogenic activity, its combination with cytotoxic chemotherapy is associated with a significantly increased risk of DVT."}
{"adverse event": [{"trigger": "associated ", "arguments": {"Subject.Population": "NAN", "Treatment.Disorder": "refractory multiple myeloma (MM)", "Subject.Age": "NAN", "Treatment.Time_elapsed": "NAN", "Subject.Disorder": "NAN", "Effect": "significantly increased risk of DVT", "Combination.Drug": ["cytotoxic", "thalidomide"], "Treatment.Freq": "NAN", "Treatment.Dosage": "NAN", "Treatment.Duration": "NAN", "Subject.Gender": "NAN", "Treatment": ["single-agent thalidomide", "combination with cytotoxic chemotherapy"], "Treatment.Route": "chemotherapy", "Subject.Race": "NAN", "Treatment.Drug": ["cytotoxic", "thalidomide"], "Subject": "NAN"}}], "potential therapeutic event": []}