{"instruction": "You are an expert in event argument extraction. Please extract event arguments and their roles from the input that conform to the schema definition, which already includes event trigger words. If an argument does not exist, return NAN or an empty dictionary. Please respond in the format of a JSON string.", "schema": [{"event_type": "adverse event", "arguments": ["Combination.Drug", "Treatment.Dosage", "Subject.Gender", "Treatment", "Subject.Disorder", "Subject", "Treatment.Time_elapsed", "Subject.Population", "Treatment.Duration", "Treatment.Disorder", "Subject.Race", "Treatment.Freq", "Effect", "Treatment.Drug"]}], "input": "Thyroid dysfunction has been reported in patients with malignant disease treated with recombinant alpha interferon."}
{"adverse event": [{"Combination.Drug": "NAN", "Treatment.Dosage": "NAN", "Subject.Gender": "NAN", "Treatment": "recombinant alpha interferon", "Subject.Disorder": "NAN", "Subject": "patients with malignant disease", "Treatment.Time_elapsed": "NAN", "Subject.Population": "NAN", "Treatment.Duration": "NAN", "Treatment.Disorder": "malignant disease", "Subject.Race": "NAN", "Treatment.Freq": "NAN", "Effect": "Thyroid dysfunction", "Treatment.Drug": "recombinant alpha interferon"}]}