{"instruction": "You are an expert in event argument extraction. Please extract event arguments and their roles from the input that conform to the schema definition, which already includes event trigger words. If an argument does not exist, return NAN or an empty dictionary. Please respond in the format of a JSON string.", "schema": [{"event_type": "adverse event", "arguments": ["Treatment.Disorder", "Subject.Race", "Subject.Age", "Effect", "Treatment.Drug", "Subject.Disorder", "Subject.Gender", "Treatment.Duration", "Treatment.Route", "Subject.Population", "Treatment.Dosage", "Treatment.Freq", "Subject", "Treatment"]}], "input": "A 69-year-old white female whose anticoagulation treatment had been stable for 18 months with warfarin 2.5 mg daily (17.5 mg/wk) presented to an anticoagulation clinic with a critically elevated INR of greater than 12.3 after a dose increase in extended-release niacin (Niaspan) from 500 mg to 1000 mg daily the previous week."}
{"adverse event": [{"Treatment.Disorder": "NAN", "Subject.Race": "white", "Subject.Age": "69-year-old", "Effect": "elevated INR of greater than 12.3", "Treatment.Drug": ["extended-release niacin", "warfarin"], "Subject.Disorder": "NAN", "Subject.Gender": "female", "Treatment.Duration": "NAN", "Treatment.Route": "NAN", "Subject.Population": "NAN", "Treatment.Dosage": ["2.5 mg", "1000 mg"], "Treatment.Freq": "daily", "Subject": "69-year-old white female", "Treatment": ["dose increase in extended-release niacin (Niaspan) from 500 mg to 1000 mg daily the previous week", "anticoagulation treatment had been stable for 18 months with warfarin 2.5 mg daily (17.5 mg/wk)"]}]}