{"instruction": "You are an expert in event extraction. Please extract events from the input that conform to the schema definition. Return an empty list for events that do not exist, and return NAN for arguments that do not exist. If an argument has multiple values, please return a list. Respond in the format of a JSON string.", "schema": [{"event_type": "adverse event", "trigger": true, "arguments": ["Subject.Population", "Subject.Gender", "Treatment.Disorder", "Treatment.Drug", "Subject.Race", "Treatment.Route", "Treatment", "Combination.Drug", "Subject.Disorder", "Treatment.Duration", "Treatment.Dosage", "Treatment.Freq", "Subject", "Effect", "Subject.Age", "Treatment.Time_elapsed"]}, {"event_type": "potential therapeutic event", "trigger": true, "arguments": ["Combination.Drug", "Treatment.Drug", "Treatment.Duration", "Treatment.Dosage", "Treatment.Time_elapsed", "Treatment.Disorder", "Subject", "Treatment", "Treatment.Route", "Subject.Population", "Treatment.Freq", "Effect"]}], "input": "The first reported case, in an adult, of cholestyramine induced hyperchloremic metabolic acidosis is a 70 year old female with a two year history of primary biliary cirrhosis confirmed by histologic and immunologic criteria."}
{"adverse event": [{"trigger": "induced ", "arguments": {"Subject.Population": "NAN", "Subject.Gender": "female", "Treatment.Disorder": "primary biliary cirrhosis", "Treatment.Drug": "cholestyramine", "Subject.Race": "NAN", "Treatment.Route": "NAN", "Treatment": "cholestyramine", "Combination.Drug": "NAN", "Subject.Disorder": "NAN", "Treatment.Duration": "NAN", "Treatment.Dosage": "NAN", "Treatment.Freq": "NAN", "Subject": "a 70 year old female with a two year history of primary biliary cirrhosis", "Effect": "hyperchloremic metabolic acidosis", "Subject.Age": "70 year old", "Treatment.Time_elapsed": "NAN"}}], "potential therapeutic event": []}