{"instruction": "You are an expert in event extraction. Please extract events from the input that conform to the schema definition. Return an empty list for events that do not exist, and return NAN for arguments that do not exist. If an argument has multiple values, please return a list. Respond in the format of a JSON string.", "schema": [{"event_type": "potential therapeutic event", "trigger": true, "arguments": ["Subject.Disorder", "Treatment.Disorder", "Treatment.Dosage", "Treatment.Drug", "Subject.Population", "Combination.Drug", "Treatment.Duration", "Treatment.Freq", "Subject.Race", "Effect"]}, {"event_type": "adverse event", "trigger": true, "arguments": ["Effect", "Treatment", "Subject.Population", "Treatment.Freq", "Subject", "Treatment.Disorder", "Subject.Age", "Combination.Drug", "Treatment.Time_elapsed", "Subject.Gender", "Treatment.Duration", "Treatment.Route", "Treatment.Dosage", "Treatment.Drug", "Subject.Race", "Subject.Disorder"]}], "input": "A 69-year-old white female whose anticoagulation treatment had been stable for 18 months with warfarin 2.5 mg daily (17.5 mg/wk) presented to an anticoagulation clinic with a critically elevated INR of greater than 12.3 after a dose increase in extended-release niacin (Niaspan) from 500 mg to 1000 mg daily the previous week."}
{"potential therapeutic event": [], "adverse event": [{"trigger": "after ", "arguments": {"Effect": "elevated INR of greater than 12.3", "Treatment": ["dose increase in extended-release niacin (Niaspan) from 500 mg to 1000 mg daily the previous week", "anticoagulation treatment had been stable for 18 months with warfarin 2.5 mg daily (17.5 mg/wk)"], "Subject.Population": "NAN", "Treatment.Freq": "daily", "Subject": "69-year-old white female", "Treatment.Disorder": "NAN", "Subject.Age": "69-year-old", "Combination.Drug": ["warfarin", "extended-release niacin"], "Treatment.Time_elapsed": "NAN", "Subject.Gender": "female", "Treatment.Duration": "NAN", "Treatment.Route": "NAN", "Treatment.Dosage": ["2.5 mg", "1000 mg"], "Treatment.Drug": ["warfarin", "extended-release niacin"], "Subject.Race": "white", "Subject.Disorder": "NAN"}}]}