{"instruction": "You are an expert in event argument extraction. Please extract event arguments and their roles from the input that conform to the schema definition, which already includes event trigger words. If an argument does not exist, return NAN or an empty dictionary. Please respond in the format of a JSON string.", "schema": [{"event_type": "potential therapeutic event", "arguments": ["Treatment.Duration", "Treatment.Drug", "Combination.Drug", "Subject", "Effect", "Treatment.Freq", "Subject.Age", "Treatment.Route", "Subject.Gender", "Treatment", "Treatment.Disorder", "Subject.Disorder", "Treatment.Time_elapsed", "Subject.Population"]}], "input": "1.\nArtelinic acid (AL), a water-soluble artemisinin analogue for treatment of multidrug resistant malaria, is metabolized to the active metabolite dihydroqinghaosu (DQHS) solely by  CYP3A4/5."}
{"potential therapeutic event": [{"Treatment.Duration": "NAN", "Treatment.Drug": "Artelinic acid", "Combination.Drug": "NAN", "Subject": "NAN", "Effect": "NAN", "Treatment.Freq": "NAN", "Subject.Age": "NAN", "Treatment.Route": "NAN", "Subject.Gender": "NAN", "Treatment": "Artelinic acid (AL), a water-soluble artemisinin analogue", "Treatment.Disorder": "multidrug resistant malaria", "Subject.Disorder": "NAN", "Treatment.Time_elapsed": "NAN", "Subject.Population": "NAN"}]}