Context:
A 33-year-old woman comes to the physician because of a 4-day history of fever and neck pain that radiates to the jaw and ears. She has also noticed swelling in the front part of her throat since the onset of the pain. She reports feeling anxious and sweating profusely over the past 2 days. She has no history of major illness and takes no medication. Her temperature is 38.1°C (100.6°F), pulse is 95/min, and blood pressure is 140/70 mm Hg. Examination shows moist palms and a bilateral fine resting tremor of the outstretched hands. Examination of the neck shows a thyroid gland that is tender, firm, and enlarged. Serum studies show:
Hemoglobin 12.7 g/dL
ESR 65 mm/h
Serum
Creatinine 0.7 mg/dL
Thyroid-stimulating hormone 0.063 μU/mL
Triiodothyronine (T3) 218 ng/dL
Thyroxine (T4) 88 μg/dL
123I scan shows an enlarged thyroid gland with multiple areas of decreased uptake. Which of the following is the most likely diagnosis?"

Question: Which of the following is the most likely diagnosis?"

Answer: Subacute thyroiditis


Context: A 20-year-old female arrives at the urgent care clinic at her university’s health plan asking for an HIV test. She is an undergraduate at the university and just started having sexual intercourse with her new boyfriend. They use protection only occasionally so she wants to get tested to make sure everything is okay. She has never been tested for STDs before. She reports no symptoms and has not seen a physician regularly for any medical conditions in the past. Her family history is uncertain because she was adopted. Her HIV immunoassay and HIV-1/HIV-2 differentiation immunoassay both come back positive. She asks on the phone, “Doctor, tell it to me straight. Do I have AIDS?” Which of the following is the most accurate response?

Question: Do I have AIDS?” Which of the following is the most accurate response?

Answer: We need additional bloodwork to see if you have AIDS.


Context:
A 32-year-old woman visits the office with a complaint of recurrent abdominal pain for the past 2 months. She says the pain has been increasing every day and is located in the right upper quadrant. She has been using oral contraceptive pills for the past 2 years. She is a nonsmoker and does not drink alcohol. Her vital signs show a heart rate of 85/min, respiratory rate of 16/min, temperature of 37.6 °C (99.68 °F), and blood pressure of 120/80 mm Hg. Physical examination reveals right upper quadrant tenderness and hepatomegaly 3 cm below the right costal border. Her serology tests for viral hepatitis are as follows:
HBsAg Negative
Anti-HBs Negative
IgM anti-HBc Negative
Anti-HCV Negative
A hepatic ultrasound shows hepatomegaly with diffusely increased echogenicity and a well-defined, predominantly hypoechoic mass in segment VI of the right lobe of the liver. What is the most likely diagnosis?

Question: What is the most likely diagnosis?

Answer: Hepatic adenoma


Context: A previously healthy 67-year-old man comes to the physician because of a history of recurrent right lower abdominal pain for the past 2 years. A CT scan shows a 1.2-cm (0.47-in) mass located in the terminal ileum. He undergoes surgical removal of the mass. A photomicrograph of the resected specimen is shown. Cells from this tissue are most likely to stain positive for which of the following?

Question: Cells from this tissue are most likely to stain positive for which of the following?

Answer: Chromogranin A


Context:
A 66-year-old woman presents to the emergency department with abdominal pain. Her symptoms began when she was eating dinner. She has a past medical history of obesity, constipation, intravenous drug use, and diabetes. The patient is instructed to be nil per os and is transferred to the surgical floor. Three days later she had a cholecystectomy and is recovering on the surgical floor. Her laboratory values are ordered as seen below.

Hemoglobin: 11 g/dL
Hematocrit: 33%
Leukocyte count: 8,500/mm^3 with normal differential
Platelet count: 197,000/mm^3

Serum:
Na+: 139 mEq/L
Cl-: 100 mEq/L
K+: 4.3 mEq/L
HCO3-: 25 mEq/L
BUN: 20 mg/dL
Glucose: 99 mg/dL
Creatinine: 1.1 mg/dL
Ca2+: 10.5 mg/dL
Alkaline phosphatase: 533 U/L
GGT: 50 U/L
AST: 22 U/L
ALT: 20 U/L

The patient is currently asymptomatic and states that she feels well. Which of the following is associated with this patient's underlying condition?

Question: Which of the following is associated with this patient's underlying condition?

Answer: Blastic and lytic skeletal lesions


Context: A 55-year-old obese woman is referred to the cardiology clinic for progressive dyspnea. She has had no recent travel or sick contacts. Besides a multivitamin, she has only tried online weight-loss medications for the past five years, including fenfluramine-phentermine. An echocardiogram reveals a dilated right ventricle with systolic pressure of 60 mmHg as well as both tricuspid and pulmonary regurgitation. A right heart catheterization shows a mean pulmonary artery pressure of 40 mmHg. What disease process is most analogous to this patient's presentation?

Question: What disease process is most analogous to this patient's presentation?

Answer: Carcinoid syndrome


Context: An 18-year-old man seeks an evaluation from a physician for painful right axillary swelling since 2 days ago. He has malaise. He has no history of serious illnesses and takes no medications. He has a pet kitten which was recently treated for fleas. The temperature is 38.5℃ (101.3℉), the pulse is 88/min, the respiration rate is 14/min, and the blood pressure is 120/80 mm Hg. There are 2 painless papules on the patient’s right forearm that appeared on the healing scratch marks left by his pet kitten a few days ago. Several lymph nodes in the right axilla are enlarged and tender. The overlying skin is erythematous. No other lymphadenopathy is detected in other areas. The rest of the examination shows no abnormalities. Which of the following is the most appropriate pharmacotherapy at this time?

Question: Which of the following is the most appropriate pharmacotherapy at this time?

Answer: No pharmacotherapy


Context: A prospective cohort study was conducted to assess the relationship between LDL-C and the incidence of heart disease. The patients were selected at random. Results showed a 10-year relative risk (RR) of 2.30 for people with elevated LDL-C levels compared to individuals with normal LDL levels. The p value was 0.04. This study is most likely to have which of the following 95% confidence intervals?

Question: This study is most likely to have which of the following 95% confidence intervals?

Answer: 1.01-3.70


Context: A 60-year-old man is brought to the emergency department by police officers because he was seen acting strangely in public. The patient was found talking nonsensically to the characters on cereal boxes in a grocery store. Past medical history is significant for multiple hospitalizations for alcohol-related injuries and alcohol withdrawal seizures. Vital signs are within normal limits. On physical examination, the patient is disheveled and oriented x1. Neurologic examination shows horizontal nystagmus and severe ataxia is also noted, that after interviewing the patient, he forgets the face of persons and the questions asked shortly after he walks out the door. He, however, remembers events from his distant past quite well. Which of the following is the most likely diagnosis in this patient?

Question: Which of the following is the most likely diagnosis in this patient?

Answer: Korsakoff amnesia


Context: A 76-year-old man presents for a follow-up appointment at his primary care provider’s office. The patient has severe osteoarthritis, which substantially limits his daily physical activity. Several imaging studies have confirmed severe articular degeneration and evidence of bone grinding on bone in his hip joints. The patient suffers from chronic pain and depression that have been resistant to medication. At the physician’s office, his blood pressure is 119/67 mm Hg, the respirations are 18/min, the pulse is 87/min, and the temperature is 36.7°C (98.0°F). On physical examination, the patient has a flat affect and appears anxious. He has significant pain and limited passive and active range of motion of his hip joints bilaterally. This patient would most likely benefit from which of the following procedures if there are no contraindications?

Question: This patient would most likely benefit from which of the following procedures if there are no contraindications?

Answer: Total hip arthroplasty


Context: A 7-year-old boy and the rest of his family visit a physician for a physical after migrating to the United States. His mother reports that her son is always fatigued and has no energy to play like the other kids in their remote village in Nigeria. He was born at 39 weeks via spontaneous vaginal delivery and is meeting all developmental milestones. He is behind on most of his vaccines, and they develop a plan to get him caught up. On examination, the boy presents with jaundice, mild hepatomegaly, and tachycardia. A CBC with manual differential reveals atypical appearing red blood cells. The physician takes time to review the lab work results with the mother, and he discusses her son’s diagnosis. It is expected that one molecule at the biochemical level should be high. Which of the following best describes this molecule and its significance in this patient?

Question: Which of the following best describes this molecule and its significance in this patient?

Answer: Pathological; an intermediate of glycolysis


Context: A 14-year-old male of eastern European descent presents to the free clinic at a university hospital for a respiratory infection, which his mother explains occurs quite frequently. The male is noted to be of short stature, have a gargoyle-like facies, clouded corneas, poor dentition, and is severely mentally retarded. A urinalysis revealed large amounts of heparan and dermatan sulfate. Which of the following is the most likely diagnosis?

Question: Which of the following is the most likely diagnosis?

Answer: Hurler's syndrome


Context: A 4-year-old girl is brought to the physician by her mother for a follow-up examination. She has a history of recurrent asthma attacks. The mother reports that her daughter has also had mild abdominal pain for the past 2 weeks. The patient's current medications include daily inhaled fluticasone and inhaled albuterol as needed. She appears well. Her temperature is 37°C (98.6°F), pulse is 100/min, and blood pressure is 130/85 mm Hg. The lungs are clear to auscultation. Cardiac examination shows no murmurs, rubs, or gallops. Abdominal examination shows a left-sided, nontender, smooth abdominal mass that does not cross the midline. The remainder of the examination shows no abnormalities. A complete blood count and serum concentrations of electrolytes, urea nitrogen, and creatinine are within the reference range. Which of the following is the most likely diagnosis?

Question: Which of the following is the most likely diagnosis?

Answer: Wilms' tumor


Context: A 58-year-old man with a history of hepatitis C infection presents to his physician because of unintentional weight loss and weakness. He has lost 6.8 kg (15 lb) within the last 6 months. Vital signs are within normal limits. Physical examination shows jaundice, splenomegaly, and caput medusae. A complete metabolic panel is ordered. Which of the following tests is the most likely to result in a diagnosis?

Question: Which of the following tests is the most likely to result in a diagnosis?

Answer: Alanine aminotransferase


Context: An investigator studying fungal growth isolates organisms from an infant with diaper rash. The isolate is cultured and exposed to increasing concentrations of nystatin. Selected colonies continue to grow and replicate even at high concentrations of the drug. Which of the following is the most likely explanation for this finding?

Question: Which of the following is the most likely explanation for this finding?

Answer: Reduced ergosterol content in cell membrane


Context: A rheumatologist is evaluating the long-term risk of venous thromboembolism in patients with newly diagnosed rheumatoid arthritis by comparing two retrospective cohort studies. In study A, the hazard ratio for venous thromboembolism was found to be 1.7 with a 95% confidence interval of 0.89–2.9. Study B identified a hazard ratio for venous thromboembolism of 1.6 with a 95% confidence interval of 1.1–2.5. Which of the following statements about the reported association in these studies is most accurate?

Question: Which of the following statements about the reported association in these studies is most accurate?

Answer: The p-value of study A is likely larger than the p-value of study B.


Context: A 17-year-old girl is brought into the clinic by her mother who is concerned that she may be depressed. The mother states that her daughter feels unattractive and does not fit into any of the social groups at school. When talking to the patient, it is discovered that she mostly avoids the kids in school because of fear of rejection. She usually keeps to herself and says she hasn’t involved herself in any group activities since elementary school. The patient’s mother is worried that this kind of behavior might continue or worsen if it progresses into her college years. Which of the following is the most likely diagnosis in this patient?

Question: Which of the following is the most likely diagnosis in this patient?

Answer: Avoidant personality disorder


Context: A 16-year-old female presents to her pediatrician complaining of 2 weeks of fever and 1 week of swollen lumps in her left armpit. Upon examination of the left upper extremity, her physician notes the presence of a single papule which the patient claimed appeared one week ago. The patient started her first job at a pet store 2.5 weeks ago. Which of the following is the vector of transmission of the causative agent?

Question: Which of the following is the vector of transmission of the causative agent?

Answer: Cats


Context: A 63-year-old woman presents to her primary care provider with her spouse for routine follow-up. She has a history of schizophrenia and is currently living at a nursing facility. Her symptoms first started 2 years ago, when she developed auditory hallucinations and her family noticed that her thoughts and speech became more tangential and disorganized. After being referred to a psychiatrist, the patient was started on medication. Currently she reports occasional auditory hallucinations, but her spouse states that her symptoms have improved dramatically with medication. On exam, her temperature is 98.4°F (36.9°C), blood pressure is 110/74 mmHg, pulse is 64/min, and respirations are 12/min. The patient has normal affect with well-formulated, non-pressured speech. She denies any audiovisual hallucinations. Notably, however, the patient has repetitive lip-smacking behavior and occasionally sweeps her tongue across her lips. The spouse is curious about how this developed. Which of the following is the most likely medication this patient was started on?

Question: Which of the following is the most likely medication this patient was started on?

Answer: Haloperidol


Context: A 65-year-old G4P4 woman presents to her primary care physician complaining of a breast lump. She reports that she felt the lump while conducting a breast self-examination. Her past medical history is notable for endometrial cancer status post radical hysterectomy. She takes aspirin and fish oil. The patient drinks 3-4 alcoholic beverages per day and has a distant smoking history. Her temperature is 98.6°F (37°C), blood pressure is 130/75 mmHg, pulse is 90/min, and respirations are 18/min. A firm palpable mass in the upper outer quadrant of the right breast is noted on physical exam. Further workup reveals invasive ductal adenocarcinoma. She eventually undergoes radical resection and is started on a medication that is known to inhibit thymidylate synthetase. This patient is at increased risk for which of the following medication adverse effects?

Question: This patient is at increased risk for which of the following medication adverse effects?

Answer: Photosensitivity


Context: A 59-year-old man is evaluated for progressive joint pain. There is swelling and tenderness over the first, second, and third metacarpophalangeal joints of both hands. His hand radiograph shows beak-like osteophytes on his 2nd and 3rd metacarpophalangeal joints, subchondral cysts, and osteopenia. He has had diabetes mellitus for 2 years which is not well controlled with medications. Lab studies show a transferrin saturation of 88% and serum ferritin of 1,200 ng/mL. This patient is at risk of which of the following complications?

Question: This patient is at risk of which of the following complications?

Answer: Hypogonadism


Context: A 60-year-old woman is brought to the emergency department because of altered mental status for 2 hours. She and her husband were at the grocery store when she suddenly could not remember why she was there or how she got there. She has not had any head trauma. She has a history of depression and migraines. She does not smoke and drinks a glass of wine each night with dinner. She takes fluoxetine daily. She appears distressed and anxious. Her vital signs are within normal limits. She is fully alert and oriented to self and place but not to time. Every few minutes she asks how she got to the emergency department. She is able to follow commands and sustain attention. She recalls 3/3 objects immediately and recalls 0/3 objects at 5 minutes. The remainder of the neurological exam shows no abnormalities. Which of the following is the most likely diagnosis?

Question: Which of the following is the most likely diagnosis?

Answer: Transient global amnesia


Context: A team of biology graduate students are performing research on epigenetics and chromosome inactivation. The goal is to silence all the genes on a chromosome at once. The team chooses to develop a model based on a known human gene that can accomplish this task in vivo. Which of the genes listed below would be a suitable model for their research?

Question: Which of the genes listed below would be a suitable model for their research?

Answer: XIST


Context: A 36-year-old man presents to a physician with the complaint of a dry cough for the last 2 months. He denies any nasal discharge, sneezing, nose congestion, blood in sputum, breathlessness, fever, or weight loss. He started smoking 2 years back. His temperature is 37.3°C (99.2°F), the heart rate is 88/min, the blood pressure is 118/78 mm Hg, and the respiratory rate is 18/min. Auscultation of the lungs reveals localized rhonchi over the left infrascapular region. His chest radiogram reveals a single, round-shaped nodule with scalloped margins in the lower zone of the left lung. The nodule is surrounded by normally aerated lung tissue, and its size is approx. 9 mm (0.35 in) in diameter. The physician explains to him that he requires further diagnostic evaluation, as the nodule could be malignant. On the radiogram, which of the following features of the nodule is associated with the increased possibility of a malignant lesion?

Question: On the radiogram, which of the following features of the nodule is associated with the increased possibility of a malignant lesion?

Answer: Lack of calcification


Context: A 23-year-old man comes to the physician because of progressive pain, redness, and swelling of his left forearm. The symptoms began after he scratched his arm on a metal table 4 days ago. Examination of the left forearm shows a 2-cm, tender, erythematous, fluctuant lesion at the site of trauma. Incision and drainage of the lesion is performed and a small amount of thick, white liquid is expressed. Which of the following cytokines is involved in the recruitment of the primary cell type found in this liquid?

Question: Which of the following cytokines is involved in the recruitment of the primary cell type found in this liquid?

Answer: IL-8


Context: Your test subject is a stout 52-year-old gentleman participating in a study on digestion. After eating a platter of meat riblets and beef strips a test subjects digestive tract undergoes vast hormonal changes. Which of the following changes likely occurred in this patient as a result of the meal?

Question: Which of the following changes likely occurred in this patient as a result of the meal?

Answer: Increased release of secretin from S cells of the duodenum


Context: A 27-year-old G1P0 woman at 25 weeks estimated gestational age presents with a blood pressure of 188/99 mm Hg during a routine prenatal visit. She has no symptoms, except for a mild headache. The patient's heart rate is 78/min. An injectable antihypertensive along with a beta-blocker is administered, and her blood pressure returns to normal within a couple of hours. She is sent home with advice to continue the beta-blocker. The patient returns after a couple of weeks with joint pain in both of her knees and fatigue. A blood test for anti-histone antibodies is positive. Which of the following is the mechanism of action of the intravenous antihypertensive medication most likely used in this patient?

Question: Which of the following is the mechanism of action of the intravenous antihypertensive medication most likely used in this patient?

Answer: Interference with action of inositol trisphosphate (IP3) on intracellular calcium release


Context: A 65-year-old man presents with acute abdominal pain accompanied by chills, nausea, and vomiting. His past medical history is significant for benign prostatic hyperplasia and diabetes mellitus type 2. His medications are tamsulosin and metformin. His last HbA1c, 5 months ago, was 6.7. He had a screening colonoscopy 5 years ago which was normal. He denies blood in the stool or urine and has had no change in bowel habits. Throughout the encounter, the patient has difficulty getting comfortable on the exam table. His temperature is 38.2°C (100.7°F), the heart rate is 103/min, the respiratory rate is 15/min, and the blood pressure is 105/85 mm Hg. Physical exam is significant for left costovertebral angle tenderness. Peritoneal signs are absent. CBC, CMP, and urinalysis results are pending. Abdominal X-ray is shown. Which of the following is the next best step in management?

Question: Which of the following is the next best step in management?

Answer: Surgical removal and antibiotics


Context:
A 74-year-old man returns to his physician to follow-up on laboratory studies obtained for anemia 2 weeks ago. He has no complaints. He has a 20-year history of hypertension and several years of knee osteoarthritis. He walks 2 miles a day. He does not smoke. He drinks alcohol moderately. He takes hydrochlorothiazide, losartan, and pain killers, including ibuprofen. The vital signs include: temperature 37.1°C (98.8°F), pulse 68/min, respiratory rate 12/min, and blood pressure 110/70 mm Hg. The physical examination shows no abnormalities. The laboratory studies show the following:
Laboratory test
Hemoglobin 10 g/dL
Mean corpuscular volume 75 μm3
Leukocyte count 5,000/mm3
Platelet count 350,000/mm3
ESR 18 mm/hr
Serum
Ferritin 5 μg/L
Iron 30 μg/L
Total iron-binding capacity 500 μg/dL
Calcium (Ca+) 9 mg/dL
Albumin 4 g/dL
Urea nitrogen 14 mg/dL
Creatinine 0.9 mg/dL
Monoclonal protein on serum electrophoresis is 12 g/L (non-IgM). Clonal bone marrow plasma cells comprise 4% of the total number of cells. Skeletal survey with magnetic resonance imaging reveals no pathologic findings. In addition to iron deficiency anemia, which of the following diagnosis is most appropriate to consider?

Question: In addition to iron deficiency anemia, which of the following diagnosis is most appropriate to consider?

Answer: Monoclonal gammopathy of undetermined significance


Context: A 2-year-old boy is brought to the physician because of fever, productive cough, and shortness of breath. Since birth, he has had multiple respiratory infections requiring treatment with antibiotics. His immunizations are up-to-date. He is in the 10th percentile for height and weight. His temperature is 38°C (100.3°F). Examination detects diffuse bilateral wheezing and cervical lymphadenopathy. Flow cytometric analysis of a serum sample from the patient fails to fluoresce after incubation with dihydrorhodamine. This patient is at greatest risk of infection with which of the following organisms?

Question: This patient is at greatest risk of infection with which of the following organisms?

Answer: Serratia marcescens


Context: A 23-year-old woman presented to the clinic for her first prenatal appointment with fatigue and pain in the perineum for the past 8 days. The past medical history is benign and she claimed to have only had unprotected intercourse with her husband. She had a documented allergic reaction to amoxicillin 2 years ago. The vaginal speculum exam revealed a clean, ulcerated genital lesion, which was tender and non-exudative. No lymphadenopathy was detected. A rapid plasma reagin (RPR) test revealed a titer of 1:64 and the fluorescent treponemal antibody absorption (FTA- abs) test was positive. What is the next best step in the management of this patient?

Question: What is the next best step in the management of this patient?

Answer: Penicillin desensitization, then intramuscular benzathine penicillin, G 2.4 million units


Context: A 63-year-old woman is brought to the emergency department by one of her neighbors because of fever and confusion. She has a 10-year history of diabetes mellitus and hemorrhoids. Her medications include insulin and metformin. Her blood pressure is 90/70 mm Hg, the pulse is 115/min, the respirations are 21/min, and the temperature is 39.5℃ (103.1℉). The cardiopulmonary examination shows no other abnormalities. The serum creatinine level is 2.5 mg/dL. An MRI shows swelling of subcutaneous soft tissue and gas. She is resuscitated with IV fluids. Broad-spectrum empiric IV antibiotics are administered. Which of the following is the most appropriate next step in management?

Question: Which of the following is the most appropriate next step in management?

Answer: Surgical debridement


Context: A previously healthy 14-year-old boy is brought to the physician for evaluation because of loss of appetite, sleeplessness, and extreme irritability for 3 weeks. He recently quit the school's football team after missing many practices. He has also been avoiding his family and friends because he is not in the mood to see them but admits that he is lonely. He has not left his room for 2 days, which prompted his father to bring him to the physician. He has no medical conditions and does not take any medications. He does not drink alcohol or use recreational drugs. While the father is in the waiting room, mental status examination is conducted, which shows a constricted affect. Cognition is intact. He says that he would be better off dead and refuses to be treated. He says he wants to use his father's licensed firearm to “end his misery” over the weekend when his parents are at church. Which of the following is the most appropriate next step in management?

Question: Which of the following is the most appropriate next step in management?

Answer: Involuntary hospitalization after informing the parents


Context: A 58-year-old man comes to the clinic complaining of increased urinary frequency for the past 3 days. The patient reports that he has had to get up every few hours in the night to go to the bathroom, and says "whenever I feel the urge I have to go right away.” Past medical history is significant for a chlamydial infection in his twenties that was adequately treated. He endorses lower back pain and subjective warmth for the past 2 days. A rectal examination reveals a slightly enlarged prostate that is tender to palpation. What is the most likely explanation for this patient’s symptoms?

Question: What is the most likely explanation for this patient’s symptoms?

Answer: Infection with Escherichia coli


Context: A 21-year-old woman presents with right eye irritation, redness, and watery discharge. These symptoms started abruptly 4 days ago. She is on summer vacation and does not report any contacts with evidently ill patients. However, during the vacation, she frequently visited crowded places. The patient denies any other symptoms. At the presentation, the patient’s vital signs include: blood pressure 125/80 mm Hg, heart rate 75/min, respiratory rate 14/min, and temperature 36.7℃ (98℉). The physical examination shows conjunctival injection, watery discharge, and mild follicular transformation of the conjunctiva of the right eye. There are no corneal lesions. Ipsilateral preauricular lymph nodes are enlarged. Which of the following would be a proper medical therapy for this patient

Question: Which of the following would be a proper medical therapy for this patient

Answer: No medical treatment required


Context: A 30-year-old man presents with a 1-month history of frequent intermittent headaches. He says the headaches typically occur between 3–4 times/day, mostly at night, each lasting minutes to 1–2 hours. He describes the pain as severe, stabbing, unilateral, and localized to the left periorbital region. He says he frequently notes increased tear production and conjunctival injection in the left eye and rhinorrhea during these headaches. He mentions that he had a similar 3-week episode of these same, frequent intermittent headaches 3 months ago which stopped completely until 1 month ago. He denies any seizures, loss of consciousness, nausea, vomiting, photophobia, or phonophobia. His past medical history is significant for stable angina secondary to coronary artery disease diagnosed on a stress echocardiogram 1 year ago. He reports occasional alcohol use, which he says precipitates the headaches, but denies any smoking or recreational drug use. The patient is afebrile, and his vital signs are within normal limits. A physical examination is unremarkable. A noncontrast computed tomography (CT) scan of the head is normal. Which of the following is the best abortive treatment for this patient?

Question: Which of the following is the best abortive treatment for this patient?

Answer: High-flow 100% oxygen


Context: A 28-year-old man comes to the physician because of skin lesions on and around his anus. He noticed them 3 days ago. The lesions are not painful and he does not have any urinary complaints. He has smoked one pack of cigarettes daily for 10 years and he drinks 6–7 beers on weekends. He is sexually active with two male partners and uses condoms inconsistently. He appears healthy. A photograph of the perianal region is shown. The lesions turn white after application of a dilute acetic acid solution. The remainder of the examination shows no abnormalities. An HIV test is negative. Which of the following is the most appropriate next step in management?

Question: Which of the following is the most appropriate next step in management?

Answer: Curettage


Context: A 28-year-old woman presents with severe diarrhea and abdominal pain. She says she has had 10 watery stools since the previous morning and is experiencing severe cramping in her abdomen. She reports similar past episodes of diarrhea with excruciating abdominal pain and mentions that she has taken diphenoxylate and atropine before which had helped her diarrhea and pain but resulted in severe constipation for a week. Which of the following receptors does diphenoxylate activate to cause the effects mentioned by this patient?

Question: Which of the following receptors does diphenoxylate activate to cause the effects mentioned by this patient?

Answer: µ receptor


Context: A 29-year-old woman comes to the physician because of poor balance and recurrent falls for the past month. She has also had blurry vision in her right eye for the past 2 weeks. She reports worsening of her symptoms after taking warm baths. Physical examination shows generalized hyperreflexia and an intention tremor. Romberg sign is positive. Visual acuity is 20/50 in the left eye and 20/100 in the right eye, and she is unable to distinguish red from green colors. The cells primarily affected by this patient's condition are most likely derived from which of the following embryologic structures?

Question: The cells primarily affected by this patient's condition are most likely derived from which of the following embryologic structures?

Answer: Neuroectoderm


Context: A 4-year-old boy is brought to the emergency department for a right ankle injury sustained during a fall earlier that morning. His parents report that he is 'clumsy' when he runs and has fallen multiple times in the last year. He has reached most of his developmental milestones but did not walk until the age of 17 months. He is an only child and was adopted at age 1. He appears tearful and in mild distress. His temperature is 37.2°C (98.9°F), pulse is 72/min, respirations are 17/min, and blood pressure is 80/50 mm Hg. His right ankle is mildly swollen with no tenderness over the medial or lateral malleolus; range of motion is full with mild pain. He has marked enlargement of both calves. Patellar and Achilles reflexes are 1+ bilaterally. Strength is 4/5 in the deltoids, knee flexors/extensors, and 5/5 in the biceps and triceps. Babinski sign is absent. When standing up from a lying position, the patient crawls onto his knees and slowly walks himself up with his hands. Which of the following is the most likely underlying mechanism of this patient's condition?

Question: Which of the following is the most likely underlying mechanism of this patient's condition?

Answer: Absence of dystrophin protein


Context: A group of 6 college students with multiple sclerosis (MS) was evaluated for flares in a neurology clinic. The results are shown in the figure. Each row represents a patient. The gray bars represent the duration of the flare. The arrowheads indicate that disease was already present before and/or persisted beyond the timeframe of the study. Based on the figure, which of the following is the most valid statement about MS flares in this group of students?

Question: Based on the figure, which of the following is the most valid statement about MS flares in this group of students?

Answer: Incidence during the month of May was 2


Context: A 33-year-old man presents to the emergency department with sudden onset right hand and right leg weakness. The patient was at home cleaning when his symptoms began. He also complains of diffuse and severe pain throughout his entire body which he states he has experienced before. The patient is an immigrant from South America, and his medical history is not known. His temperature is 98.9°F (37.2°C), blood pressure is 128/67 mmHg, pulse is 80/min, respirations are 16/min, and oxygen saturation is 99% on room air. CT of the head demonstrates no bleeding. Physical exam is notable for 2/5 strength in the patient's right arm and right leg. Which of the following is the best management in this patient?

Question: Which of the following is the best management in this patient?

Answer: Exchange transfusion


Context: A 28-year-old man presents to his primary care physician because he has been experiencing constipation for the last 6 days. He says that the constipation started 1 day after he started taking an over the counter medication for sinus congestion and a chronic cough. He has no other findings associated with the constipation. His past medical history is significant for seasonal allergies but he is not currently taking any other medications besides the one he reported. Which of the following drugs was most likely responsible for this patient's symptoms?

Question: Which of the following drugs was most likely responsible for this patient's symptoms?

Answer: Dextromethorphan


Context: A 28-year-old woman follows up at an outpatient surgery clinic with an abnormal scarring of her incisional wound from an abdominal surgical procedure  6 months ago. She gives a history of a wound infection with a purulent discharge 1 week after surgery. On examination of the scar, a dense, raised, healed lesion is noted at the incision site. She also complains of an occasional itching sensation over the scar. There is no history of such scar changes in her family. An image of the lesion is given below. Which of the following statements best describe the scar abnormality?

Question: Which of the following statements best describe the scar abnormality?

Answer: There is excessive scar tissue projecting beyond the level of the surrounding skin, but not extending into the underlying subcutaneous tissue.


Context: You are attempting to quantify the degree of infectivity of a novel respiratory virus. You assess 1,000 patients who have been exposed to the virus and find that 500 ultimately are found positive for the virus within a 1-year follow up period. Conversely, from a 1,000 patient control group who has not been exposed to carriers of the virus, only 5 became positive over the same 1-year period. What is the relative risk of a contracting this virus if exposed?

Question: What is the relative risk of a contracting this virus if exposed?

Answer: [500/ (500 + 500)] / [5 / (5 + 995)]


Context:
A 19-year-old man comes to the physician because of recurrent yellowing of his eyes over the past 2 years. He reports that each episode lasts 1–2 weeks and resolves spontaneously. He has no family history of serious illness. He recently spent a week in Mexico for a vacation. He is sexually active with two partners and uses condoms inconsistently. He does not drink alcohol or use illicit drugs. His vital signs are within normal limits. Physical examination shows jaundice of the conjunctivae and the skin. The abdomen is soft with no organomegaly. The remainder of the physical examination shows no abnormalities. Laboratory studies show:
Serum
Total bilirubin 4.0 mg/dL
Direct bilirubin 3.0 mg/dL
Alkaline phosphatase 75 U/L
AST 12 U/L
ALT 12 U/L
Anti-HAV IgG positive
HBsAg negative
Anti-HBsAg positive
HCV RNA negative
Urine
Bilirubin present
Urobilinogen normal
Which of the following is the most likely underlying cause of this patient's condition?"

Question:
Laboratory studies show:
Serum
Total bilirubin 4.0 mg/dL
Direct bilirubin 3.0 mg/dL
Alkaline phosphatase 75 U/L
AST 12 U/L
ALT 12 U/L
Anti-HAV IgG positive
HBsAg negative
Anti-HBsAg positive
HCV RNA negative
Urine
Bilirubin present
Urobilinogen normal
Which of the following is the most likely underlying cause of this patient's condition?"

Answer: Impaired hepatic storage of bilirubin


Context: A 49-year-old man presents to his primary care provider complaining of weakness and fatigue. He reports that he has started moving slower than normal and has noticed difficulty buttoning up his pants or tying his tie. He is accompanied by his wife who reports that he has started to move more slowly over the past 2 years. He has also become increasingly irritable and has had trouble sleeping. His past medical history is notable for hypertension, diabetes mellitus, and obesity. He takes enalapril and metformin. His family history is notable for multiple strokes in his mother and father. His temperature is 99°F (37.2°C), blood pressure is 140/90 mmHg, pulse is 90/min, and respirations are 17/min. On exam, strength is 4+/5 bilaterally in his upper extremities and 4/5 in his lower extremities. Some muscle atrophy is noted in his legs and feet. Patellar reflexes are 3+ bilaterally. He has a tremor in his right hand that diminishes when he is instructed to hold a pen in his hand. He is oriented to person, place and time. He states that he feels depressed but denies suicidal ideation. His physician prescribes multiple medications including a drug that is also indicated in the treatment of prolactinomas. Which of the following is the mechanism of action of this medication?

Question: Which of the following is the mechanism of action of this medication?

Answer: Activate dopamine receptors


Context: A 1-year-old boy is brought to his pediatrician for a follow-up appointment. He was recently diagnosed with failure to thrive and developmental delay. His weight is 7 kg (15.4 lb), height is 61 cm (24 in), and head circumference is 42 cm (16.5 in). The patient’s father had a younger sister who suffered from mental and physical delay and died at a very young age. The patient was able to raise his head at the age of 7 months and began to sit alone only recently. He babbles, coos, and smiles to other people. On presentation, his blood pressure is 75/40 mm Hg, heart rate is 147/min, respiratory rate is 28/min, and temperature is 36.4°C (97.5°F). He has a coarse face with small deep orbits, proptotic eyes, big lips, and gingival hyperplasia. His skin is pale with decreased elasticity. His lung and heart sounds are normal. Abdominal examination reveals diminished anterior abdominal wall muscle tone and hepatomegaly. Muscle tone is increased in all groups of muscles on both upper and lower extremities. The physician becomes concerned and performs testing for the suspected hereditary disease. A blood test shows increased lysosomal enzyme concentration in the serum and decreased N-acetylglucosamine-1-phosphotransferase (GlcNAc phosphotransferase) activity within the leukocytes. Which of the statements listed below describes the mechanism of the patient’s condition?

Question: Which of the statements listed below describes the mechanism of the patient’s condition?

Answer: The lysosomal enzymes are secreted from the cells instead of being targeted to lysosomes because of lack of mannose phosphorylation on N-linked glycoproteins.


Context: A 13-year-old girl presents with a right infected ingrown toenail. On examination, the skin on the lateral side of the toe is red, warm, swollen, and severely tender to touch. When gentle pressure is applied, pus oozes out. Culture and sensitivity analysis of the pus shows methicillin-resistant Staphylococcus aureus (MRSA). Which of the following antibiotics is most effective against this organism?

Question: Which of the following antibiotics is most effective against this organism?

Answer: Clindamycin


Context:
A 39-year-old man comes to the physician for a follow-up examination. He was diagnosed with latent tuberculosis infection 3 months ago. He has had generalized fatigue and dyspnea on exertion for the past 6 weeks. He does not smoke and drinks 2–3 beers on weekends. Vital signs are within normal limits. Examination shows conjunctival pallor. Laboratory studies show:
Hemoglobin 7.8 g/dL
Mean corpuscular volume 72 μm3
Red cell distribution width 17% (N = 13–15)
Reticulocyte count 0.7%
Leukocyte count 6,800/mm3
Platelet count 175,000/mm3
Serum
Creatinine 0.8 mg/dL
Iron 246 μg/dL
Ferritin 446 ng/mL
Total iron-binding capacity 212 μg/dL (N = 250–450)
Which of the following is the most likely cause of this patient's symptoms?"

Question:
Laboratory studies show:
Hemoglobin 7.8 g/dL
Mean corpuscular volume 72 μm3
Red cell distribution width 17% (N = 13–15)
Reticulocyte count 0.7%
Leukocyte count 6,800/mm3
Platelet count 175,000/mm3
Serum
Creatinine 0.8 mg/dL
Iron 246 μg/dL
Ferritin 446 ng/mL
Total iron-binding capacity 212 μg/dL (N = 250–450)
Which of the following is the most likely cause of this patient's symptoms?"

Answer: Adverse effect of medication


Context: A 33-year-old woman comes to the physician for a follow-up examination. She was treated for a urinary stone 1 year ago with medical expulsive therapy. There is no personal or family history of serious illness. Her only medication is an oral contraceptive pill that she has been taking for 12 years. She appears healthy. Physical examination shows no abnormalities. A complete blood count, serum creatinine, and electrolytes are within the reference range. Urinalysis is within normal limits. An ultrasound of the abdomen shows a well-demarcated hyperechoic 3-cm (1.2-in) hepatic lesion. A contrast-enhanced CT of the abdomen shows a well-demarcated 3-cm hepatic lesion with peripheral enhancement and subsequent centripetal flow followed by rapid clearance of contrast. There is no hypoattenuating central scar. In addition to stopping the oral contraceptive pill, which of the following is the most appropriate next step in management?

Question: In addition to stopping the oral contraceptive pill, which of the following is the most appropriate next step in management?

Answer: Reimage in 6 months


Context: A 73-year-old man is brought to the emergency department because of fever, malaise, dyspnea, and a productive cough with purulent sputum for the past day. His temperature is 39.2°C (102.6°F). Pulmonary examination shows crackles over the right upper lung field. Sputum Gram stain shows gram-positive cocci. Despite the appropriate treatment, the patient dies 5 days later. At autopsy, gross examination shows that the right lung has a pale, grayish-brown appearance and a firm consistency. Microscopic examination of the tissue is most likely to show which of the following?

Question: Microscopic examination of the tissue is most likely to show which of the following?

Answer: Fibrinopurulent leukocytic exudate with lysed erythrocytes


Context: A 27-year-old woman presents to the clinic with a runny nose and productive cough for the past two weeks. She also complains of headaches and lethargy. She was started on sertraline after she was diagnosed with major depressive disorder 2 months ago and had the dosage periodically increased to achieve symptom control. She is afraid of starting any other medication because of possible side-effects or life-threatening drug interactions. What advice is the most accurate regarding possible complication to her current pharmacotherapy?

Question: What advice is the most accurate regarding possible complication to her current pharmacotherapy?

Answer: Migraine medication can trigger a life-threatening complication.


Context: A 24-year-old man presents to the office, complaining of a rash and “not feeling well.” The patient reports fatigue, a headache, and a possible fever. He says he has felt this way since a camping trip with his family in North Carolina, but he denies any contact with sick individuals. On examination, his vital signs include: temperature 38.5°C (101.3°F), blood pressure 100/60 mm Hg, heart rate 82 beats per minute, respiratory rate 14 breaths per minute, and O2 saturation 99% on room air. The patient appears unwell. He has a maculopapular rash on his upper and lower extremities, including the palms of his hands and soles of his feet. He says he started feeling sick a few days before he got the rash, which prompted him to come into the office. The patient denies itching but admits to some nausea and vomiting. He also admits to unprotected sex with a single female partner for the past three years. What is the most likely causative agent of this patient’s presentation?

Question: What is the most likely causative agent of this patient’s presentation?

Answer: A gram-negative bacteria transmitted via the Dermacentor tick


Context: A 67-year-old man presents to the emergency department with anxiety and trouble swallowing. He states that his symptoms have slowly been getting worse over the past year, and he now struggles to swallow liquids. He recently recovered from the flu. Review of systems is notable only for recent weight loss. The patient has a 33 pack-year smoking history and is a former alcoholic. Physical exam is notable for poor dental hygiene and foul breath. Which of the following is the most likely diagnosis?

Question: Which of the following is the most likely diagnosis?

Answer: Squamous cell carcinoma


Context: A group of scientists studied the effects of cytokines on effector cells, including leukocytes. They observed that interleukin-12 (IL-12) is secreted by antigen-presenting cells (APCs) in response to bacterial lipopolysaccharide. When a CD4+ T cell is exposed to this interleukin, which of the following responses will it have?

Question: When a CD4+ T cell is exposed to this interleukin, which of the following responses will it have?

Answer: Cell-mediated immune responses


Context: A 36-year-old woman presents with a whitish vaginal discharge over the last week. She also complains of itching and discomfort around her genitals. She says her symptoms are getting progressively worse. She has been changing her undergarments frequently and changed the brand of detergent she uses to wash her clothes, but it did not resolve her problem. Additionally, she admits to having painful urination and increased urinary frequency for the past one month, which she was told are expected side effects of her medication. The patient denies any recent history of fever or malaise. She has 2 children, both delivered via cesarean section in her late twenties. Past medical history is significant for hypertension and diabetes mellitus type 2. Current medications are atorvastatin, captopril, metformin, and empagliflozin. Her medications were changed one month ago to improve her glycemic control, as her HbA1c at that time was 7.5%. Her vital signs are a blood pressure of 126/84 mm Hg and a pulse of 78/min. Her fingerstick glucose is 108 mg/dL. Pelvic examination reveals erythema and mild edema of the vulva. A thick, white, clumpy vaginal discharge is seen. The vaginal pH is 4.0. Microscopic examination of a KOH-treated sample of the discharge demonstrates lysis of normal cellular elements with branching pseudohyphae. Which of the following is the next best step in the management of this patient?

Question: Which of the following is the next best step in the management of this patient?

Answer: Start fluconazole.


Context: A 44-year-old female patient comes to the physician’s office with her husband with complaints of abdominal pain. For the past 4 months, she has experienced cramping right upper quadrant pain that starts after meals. The physician performs a right upper quadrant ultrasound that shows round echogenic masses in the gallbladder. The physician offers an elective cholecystectomy to the patient to improve her symptoms and explains the procedure in detail to the patient including potential risks and complications. The patient acknowledges and communicates her understanding of her diagnosis as well as the surgery and decides to proceed with the surgery in one month. The patient signs a form indicating her consent to this procedure. Which of the following must also be communicated to the patient at this time?

Question: Which of the following must also be communicated to the patient at this time?

Answer: The patient has the right to revoke her consent at any time before the procedure


Context: A patient presents to the clinic with symptoms of dizziness on standing up. He says it started soon after he was diagnosed with hypertension and started taking treatment for it. He has no other medical history. The physician decides to switch to another antihypertensive that does not cause orthostatic hypotension. Which of the following should be the drug of choice for this patient?

Question: Which of the following should be the drug of choice for this patient?

Answer: Propanolol


Context: A 42-year-old woman comes to the physician with a 6-month history of breast tenderness and menstrual irregularities. Physical examination shows no abnormalities. An ultrasound of the pelvis shows a right adnexal mass. A laparoscopic right salpingo-oophorectomy is performed. Histologic examination of the adnexal mass shows small cuboidal cells arranged in clusters surrounding a central cavity with eosinophilic secretions. These cells resemble primordial follicles. Which of the following laboratory values was most likely increased in this patient at the time of presentation?

Question: Which of the following laboratory values was most likely increased in this patient at the time of presentation?

Answer: Estradiol


Context: A 50-year-old man presents to the emergency department complaining of chest pain and drooling that started immediately after eating a steak. His past medical history is significant for lye ingestion 5 years ago during a suicidal attempt. He also suffers from hypertension and diabetes mellitus, type 2. He takes fluoxetine, lisinopril, and metformin every day. He also regularly sees a counselor to cope with his previous suicide attempt. Both of his parents are still alive and in good health. His heart rate is 96/min, temperature is 36.7°C (98.1°F).On physical examination, the patient can talk normally and breaths without effort. He is drooling. The chest pain is vague and constant. A chest X-ray shows no subcutaneous emphysema. An endoscopy confirms the presence of a retained bolus of meat 24 cm beyond the incisors where a stricture is identified. The bolus is removed and the stricture is dilated. Which of the following anatomic spaces contains the stricture?

Question: Which of the following anatomic spaces contains the stricture?

Answer: The superior mediastinum


Context: A 45-year-old man presents with a chief complaint of pain in the great toe. He has a history of gout, which is under control. He was diagnosed with diabetes 5 years ago and is currently taking metformin. He was recently diagnosed with hypertension and was placed on a hypertensive drug. He is a non-smoker and does not abuse alcohol. The family history is significant for ischemic heart disease in his father. His current blood pressure is 136/84 mm Hg and the pulse is 78/min. The physical examination did not reveal any abnormalities. He uses over-the-counter multivitamin supplements. Which of the following drugs could have resulted in these symptoms?

Question: Which of the following drugs could have resulted in these symptoms?

Answer: Thiazide diuretics


Context: A 15-year-old girl is brought to the physician for a school physical examination. She feels well. She is performing well in school and getting good grades. She is 147 cm (4 ft 10 in) tall and weighs 60 kg (132 lbs); BMI is 27.6 kg/m2. Her temperature is 37°C (98.6°F), pulse is 82/min, respirations are 16/min, and blood pressure is 138/82 mm Hg in the left arm and 110/74 mm Hg in the left leg. Physical examination shows an unusually short and broad neck with bilateral excess skin folds that extend to the shoulders and low-set ears. There is an increased carrying angle when she fully extends her arms at her sides. An x-ray of the chest shows inferior rib notching. Which of the following additional findings is most likely in this patient?

Question: Which of the following additional findings is most likely in this patient?

Answer:
Streak ovaries on pelvic ultrasound
"


Context: A 27-year-old woman, gravida 2, para 1, at 32 weeks' gestation comes to the physician for a prenatal visit. She feels that her baby's movements have decreased recently. She says that she used to feel 10–12 movements/hour earlier, but that it has recently decreased to about 7–8/hour. Pregnancy and delivery of her first child were uncomplicated. Medications include folic acid and a multivitamin. Her temperature is 37.2°C (99°F), and blood pressure is 108/60 mm Hg. Pelvic examination shows a uterus consistent in size with a 32-week gestation. The fetus is in a transverse lie presentation. The fetal heart rate is 134/min. A 14-minute recording of the nonstress test is shown. Which of the following is the most appropriate next step in managing this patient?

Question: Which of the following is the most appropriate next step in managing this patient?

Answer: Provide reassurance to the mother


Context: А 41-уеаr-old woman рrеѕеnts to thе offісе wіth a сomрlаіnt of а hеаdасhе for 1 month and a еріѕodе of аbnormаl bodу movеmеnt. The headaches are more severe іn thе mornіng, moѕtlу after waking up. Ѕhе doеѕn’t give a history of any mајor іllnеѕѕ or trauma in the past. Неr vіtаlѕ ѕіgnѕ include: blood рrеѕѕurе 160/80 mm Нg, рulѕе 58/mіn, tеmреrаturе 36.5°C (97.8°F), аnd rеѕріrаtorу rаtе 11/mіn. Оn fundoscopic ехаmіnаtіon, mіld раріllеdеmа is present. Her рuріlѕ аrе еquаl аnd rеасtіvе to lіght. No foсаl nеurologісаl dеfісіt сan bе еlісіtеd. A contrast computed tomography scan of the head is shown in the picture. Which of the following is the most likely biopsy finding in this case?

Question: Which of the following is the most likely biopsy finding in this case?

Answer: Spindle cells concentrically arranged in whorled pattern with laminated calcification


Context: A 40-year-old woman has complaints of dyspnea, cough, and arthritis in her ankle joints. A CT scan reveals multiples granulomas in both lungs, as well as bilateral hilar lymphadenopathy. On examination, cutaneous nodules over the trunk are found. Erythrocyte sedimentation rate, angiotensin-converting enzyme, and serum calcium levels are elevated. She is treated with steroids. What is the most likely diagnosis?

Question: What is the most likely diagnosis?

Answer: Sarcoidosis


Context: A cell biologist is studying the activity of a novel chemotherapeutic agent against a cancer cell line. After incubation with the agent and cell detachment from the tissue culture plate, the DNA is harvested from the cells and run on a gel. Of note, there are large bands at every multiple of 180 base pairs on the gel. Which of the following explains the pathophysiology of this finding?

Question: Which of the following explains the pathophysiology of this finding?

Answer: Caspase activation


Context:
A 2-week-old newborn is brought to the physician because of worsening feeding difficulty since birth. Examination shows a grade 2/6 harsh holosystolic murmur, heard most clearly at the left lower sternal border, and a soft mid-diastolic rumble over the cardiac apex. Echocardiography shows shunting of blood through the ventricular septum during systole. The patient undergoes surgery for closure of the defect. Which of the following sets of changes are expected after successful repair of this cardiac defect?
 $$$ Left atrial pressure %%% Left ventricular pressure %%% Right ventricular pressure $$$

Question: $$$ Left atrial pressure %%% Left ventricular pressure %%% Right ventricular pressure $$$


Context: A 77-year-old man with a history of advanced dementia, hypertension, Parkinson’s disease, and diabetes mellitus type 2 is brought to the hospital from a nursing home after several days of non-bloody diarrhea and vomiting. The patient is evaluated and admitted to the hospital. Physical examination shows a grade 2/6 holosystolic murmur over the left upper sternal border, clear lung sounds, a distended abdomen with normal bowel sounds, a resting tremor, and 2+ edema of the lower extremities up to the ankle. Over the next few hours, the nurse records a total of 21 cc of urine output over the past 5 hours. Which of the following criteria suggest pre-renal failure?

Question: Which of the following criteria suggest pre-renal failure?

Answer: Fractional excretion of sodium of 0.5%


Context: A 7-year-old boy is brought to the physician by his mother because of a 2-week history of intermittent shortness of breath and a dry cough that is worse at night. He had an upper respiratory tract infection 3 weeks ago. Lungs are clear to auscultation. Spirometry shows normal forced vital capacity and peak expiratory flow rate. The physician administers a drug, after which repeat spirometry shows a reduced peak expiratory flow rate. Which of the following drugs was most likely administered?

Question: Which of the following drugs was most likely administered?

Answer: Methacholine


Context: А 42-уеаr-old woman рrеѕеntѕ wіth fасіаl аѕуmmеtrу. The patient says yesterday she noticed that her face appeared to be dеvіаted to the rіght. Ѕhе dеnіеѕ аnу trаumа or rесеnt trаvеl. Неr раѕt mеdісаl hіѕtorу іѕ nonсontrіbutorу. Her vitals are blood pressure 110/78 mm Hg, temperature 36.5°C (97.8°F), pulse 78/min, and respiratory rate 11/min. Оn рhуѕісаl ехаmіnаtіon, thеrе іѕ drooріng of thе left ѕіdе of thе fасе. Тhе left nаѕolаbіаl fold іѕ аbѕеnt, аnd ѕhе іѕ unаblе to сloѕе hеr left еуе or wrinkle thе left ѕіdе of hеr forеhеаd. Whеn the patient аѕkеd to ѕmіlе, thе resulting аѕуmmеtrу is shown in the given photograph. The remainder of the nеurologіс ехаm іѕ normаl. A noncontrast CT scan of the head is unremarkable. Which of the following is the most likely cause of her presentation?

Question: Which of the following is the most likely cause of her presentation?

Answer: Idiopathic


Context: You are the intern on the labor and delivery floor. Your resident asks you to check on the patient in Bed 1. She is a 27-year-old prima gravida with no significant past medical history. She has had an uncomplicated pregnancy and has received regular prenatal care. You go to her bedside and glance at the fetal heart rate tracing (Image A). What is the most likely cause of this finding?

Question: What is the most likely cause of this finding?

Answer: Fetal head compression


Context: A 22-year-old woman presents to her primary care provider with an unrelenting headache accompanied by fever, chills, and malaise for the past 4 days. She also complains of an earache and dry hacking cough. Past medical history is noncontributory. She takes oral contraceptives and a multivitamin with calcium daily. She drinks alcohol socially and smokes occasionally. Today, her temperature is 37.9°C (100.2°F), pulse is 104/min, respiratory rate is 20/min and blood pressure is 102/82 mm Hg. On physical exam, she appears uncomfortable, but not ill. Her heart rate is elevated with a regular rhythm and her lungs have mild rhonchi in the lower lobes bilaterally. A chest X-ray shows patchy, diffuse infiltrates of the interstitium bilaterally that is worse in the lower lobes. A sputum culture is taken for stereomicroscopy. The pathogen organism appears small, pleomorphic, and lacks a cell wall. Which of the following is the most likely pathogen?

Question: Which of the following is the most likely pathogen?

Answer: Mycoplasma pneumonia


Context: One day after doctors helped a 28-year-old primigravid woman deliver a 4,700 g (10 lb 6 oz) boy, the newborn has bluish discoloration of the lips and fingernails. His temperature is 37.3°C (99.1°F), the pulse is 166/min, the respirations are 63/min, and the blood pressure is 68/44 mm Hg. Pulse oximetry on room air shows an oxygen saturation of 81%. Examination shows central cyanosis. A grade 2/6 holosystolic murmur is heard over the left lower sternal border. A single second heart sound is present. Supplemental oxygen does not improve cyanosis. An X-ray of the chest shows an enlarged cardiac silhouette with a narrowed mediastinum. Which of the following cardiac defects would be associated with this newborn’s diagnosis?

Question: Which of the following cardiac defects would be associated with this newborn’s diagnosis?

Answer: Ventricular septal defect


Context: A 44-year-old woman is admitted after an episode of dizziness and palpitations with a subsequent loss of consciousness. At the time of admission, the patient is alert, but then quickly becomes lethargic and reports reoccurrence of palpitations. Past medical history is significant for an episode of ventricular tachycardia 4 months ago, now managed with pharmacologic antiarrhythmic prophylaxis. An ECG is obtained and is shown on the image. Which of the following antiarrhythmic drugs below is most likely responsible for this patient's condition?

Question: Which of the following antiarrhythmic drugs below is most likely responsible for this patient's condition?

Answer: Sotalol


Context: A 62-year-old woman presents to the clinic with a lacerated wound on her left forearm. She got the wound accidentally when she slipped in her garden and scraped her hand against some nails sticking out of the fence. The patient has rheumatoid arthritis and takes methylprednisolone 16 mg/day. She cannot recall her vaccination history. On physical examination her blood pressure is 140/95 mm Hg, heart rate is 81/min, respiratory rate is 16/min, and temperature is 36.9°C (98.4°F). The wound is irregularly shaped and lacerated and measures 4 × 5 cm with a depth of 0.5 cm. It is contaminated with dirt. The physician decides to administer both the tetanus toxoid and immunoglobulin after wound treatment. What is true regarding the tetanus prophylaxis in this patient?

Question: What is true regarding the tetanus prophylaxis in this patient?

Answer: The immunoglobulin administration will provide sufficient levels of anti-tetanus toxin antibodies until the production of the patient’s own antibodies starts.


Context:
A 50-year-old man is brought to the emergency department because of a 3-day history of left flank pain. The patient has had two episodes of urolithiasis during the last year. He initially had pain with urination that improved with oxycodone. Over the past day, the pain has worsened and he has additionally developed fever and chills. He has hypertension and type 2 diabetes mellitus. He has smoked one pack of cigarettes daily for 20 years. He does not drink alcohol. His current medications include metformin and lisinopril. The patient appears ill and uncomfortable. His temperature is 39.1°C (102.3°F), pulse is 108/min, respirations are 22/min, and blood pressure is 90/62 mm Hg. The lungs are clear to auscultation. Cardiac examination shows no murmurs, rubs, or gallops. Examination of the back shows left costovertebral angle tenderness. Physical and neurologic examinations show no other abnormalities. Laboratory studies show:
Hemoglobin 14.2 g/dL
Leukocyte count 13,900/mm3
Hemoglobin A1c 8.2%
Serum
Na+ 138 mEq/L
K+ 3.8 mEq/L
Cl-
98 mEq/L
Calcium 9.3 mg/dL
Glucose 190 mg/dL
Creatinine 2.1 mg/dL
Urine pH 8.3
Urine microscopy
Bacteria moderate
RBC 6–10/hpf
WBC 10–15/hpf
WBC casts numerous
Ultrasound shows enlargement of the left kidney with a dilated pelvis and echogenic debris. CT scan shows a 16-mm stone at the left ureteropelvic junction, dilation of the collecting system, thickening of the wall of the renal pelvis, and signs of perirenal inflammation. Intravenous fluid resuscitation and intravenous ampicillin, gentamicin, and morphine are begun. Which of the following is the most appropriate next step in the management of this patient?"

Question: Which of the following is the most appropriate next step in the management of this patient?"

Answer: Percutaneous nephrostomy


Context: A 48-year-old homeless man is brought to the emergency department 2 hours after his right arm was burned by a fire. He is diagnosed with extensive third-degree burns of the right forearm and upper arm and is admitted to the hospital for debridement and grafting. During his stay in the hospital, he suddenly develops confusion and agitation. Neurologic examination shows horizontal nystagmus and a broad-based gait. Laboratory studies show decreased erythrocyte transketolase activity. Administration of which of the following most likely caused this patient's current condition?

Question: Administration of which of the following most likely caused this patient's current condition?

Answer: Glucose


Context: An 11-year-old girl comes to the physician with her mother because of a 2-day history of passing “cola-colored“ urine. During the past week, her mother noticed episodes of facial swelling. The patient had a rash on her face about 4 weeks ago. A renal biopsy after immunofluorescence is shown. Which of the following is the most likely diagnosis?

Question: Which of the following is the most likely diagnosis?

Answer: Poststreptococcal glomerulonephritis


Context: A 69-year-old woman with type 2 diabetes mellitus has an HbA1c of 3.9% and has been using basal-bolus insulin to manage her diabetes for the past 5 years. She has been maintaining a healthy diet, taking her insulin as scheduled but her records show morning hyperglycemia before eating breakfast. To determine the cause of this hyperglycemia, you ask her to set an alarm and take her blood glucose at 3 am. At 4 am her blood glucose is 49 mg/dL. Which of the following statements best describes the management of this patient’s current condition?

Question: Which of the following statements best describes the management of this patient’s current condition?

Answer: She is experiencing Somogyi effect so her nighttime insulin should be decreased


Context: A 37-year-old man is brought to the emergency department after being attacked with a knife. Physical examination shows a 4-cm laceration in the midline of the right forearm. An MRI of the right arm shows damage to a nerve that runs between the superficial and deep flexor digitorum muscles. Loss of sensation over which of the following areas is most likely in this patient?

Question: Loss of sensation over which of the following areas is most likely in this patient?

Answer: Fingertip of the index finger


Context: A 25-year-old nulliparous woman at 8 weeks' gestation comes to her physician accompanied by her husband for her first prenatal visit. She has no personal or family history of serious illness. Her vaccinations are up-to-date and she takes no medications. She has no history of recreational drug use and does not drink alcohol. Her vital signs are within normal limits. She is 167 cm (5 ft 6 in) tall and weighs 68 kg (150 lb); BMI is 24.3 kg/m2. She tested negative for HIV, Chlamydia trachomatis, and Neisseria gonorrhoeae 4 years ago. Which of the following tests should be done at this visit?

Question: Which of the following tests should be done at this visit?

Answer: ELISA for HIV, rapid plasma reagin test, and serum HBsAg


Context: A 24-year-old woman presents with generalized edema, hematuria, and severe right-sided flank pain. Her vital signs are normal. A 24-hour urine collection shows >10 grams of protein in her urine. Serum LDH is markedly elevated. Contrast-enhanced spiral CT scan shows thrombosis of the right renal vein. Which of the following is the most likely mechanism behind this thrombosis?

Question: Which of the following is the most likely mechanism behind this thrombosis?

Answer: Urinary loss of antithrombin III


Context: Ten days after undergoing left hip replacement, a 73-year-old hospitalized man develops a fever, dyspnea, cough productive of yellow sputum, confusion, nausea, and diarrhea. Several patients in the hospital report similar symptoms. Physical examination shows decreased breath sounds on the left side and inspiratory crackles over the left lung. An x-ray of the chest shows opacities in the lower lobe of the left lung. Treatment with ampicillin does not improve his symptoms. Subsequent evaluation of the patient's urine detects a pathogen-specific antigen, confirming the diagnosis. Which of the following sources of infection is most likely responsible for this local disease outbreak?

Question: Which of the following sources of infection is most likely responsible for this local disease outbreak?

Answer: Colonization of the air conditioning system


Context: A group of scientists is studying various methods of bacterial reproduction. They find out that bacteria also exchange genetic material via these reproductive processes. They are about to study one such method known as bacterial conjugation. Which of the following occurs through bacterial conjugation?

Question: Which of the following occurs through bacterial conjugation?

Answer: Two Pseudomonas aeruginosa bacteria with identical copies of a plasmid after sharing DNA through sex pili.


Context:
An 81-year-old man is brought in by his neighbor with altered mental status. The patient’s neighbor is unsure exactly how long he was alone, but estimates that it was at least 3 days. The neighbor says that the patient usually has his daughter at home to look after him but she had to go into the hospital recently. The patient is unable to provide any useful history. Past medical history is significant for long-standing hypercholesterolemia and hypertension, managed medically with rosuvastatin and hydrochlorothiazide, respectively. His vital signs include: blood pressure, 140/95 mm Hg; pulse, 106/min; temperature, 37.2°C (98.9°F); and respiratory rate, 19/min. On physical examination, the patient is confused and unable to respond to commands. His mucus membranes are dry and he has tenting of the skin. The remainder of the exam is unremarkable. Laboratory findings are significant for the following:
Sodium 141 mEq/L
Potassium 4.1 mEq/L
Chloride 111 mEq/L
Bicarbonate 21 mEq/L
BUN 40 mg/dL
Creatinine 1.4 mg/dL
Glucose (fasting) 80 mg/dL
  Magnesium 1.9 mg/dL
Calcium 9.3 mg/dL
Phosphorous 3.6 mg/dL
24-hour urine collection
Urine Sodium 169 mEq/24 hr (ref: 100–260 mEq/24 hr)
Urine Creatinine 79.5 g/24 hr (ref: 1.0–1.6 g/24 hr)
Which of the following is the most likely cause of this patient’s acute renal failure?

Question:
Laboratory findings are significant for the following:
Sodium 141 mEq/L
Potassium 4.1 mEq/L
Chloride 111 mEq/L
Bicarbonate 21 mEq/L
BUN 40 mg/dL
Creatinine 1.4 mg/dL
Glucose (fasting) 80 mg/dL
  Magnesium 1.9 mg/dL
Calcium 9.3 mg/dL
Phosphorous 3.6 mg/dL
24-hour urine collection
Urine Sodium 169 mEq/24 hr (ref: 100–260 mEq/24 hr)
Urine Creatinine 79.5 g/24 hr (ref: 1.0–1.6 g/24 hr)
Which of the following is the most likely cause of this patient’s acute renal failure?

Answer: Dehydration


Context: A 52-year-old man is brought to the emergency department by a friend because of a 5-day history of fever and cough productive of purulent sputum. One week ago, he was woken up by an episode of heavy coughing while lying on his back. He drinks large amounts of alcohol daily and has spent most of his time in bed since his wife passed away 2 months ago. His temperature is 38°C (100.4°F), pulse is 96/min, respirations are 24/min, and blood pressure is 110/84 mm Hg. Pulse oximetry on room air shows an oxygen saturation of 87%. Physical examination shows poor dentition and swollen gums. A CT scan of the chest is most likely to show a pulmonary infiltrate in which of the following locations?

Question: A CT scan of the chest is most likely to show a pulmonary infiltrate in which of the following locations?

Answer: Superior segment of the right lower lobe


Context: A 42-year-old man is brought to the emergency department because his neck was fixed in lateral flexion. For the past week, the patient has been complaining of low-grade fever, head pain, and neck pain. His partner has also noticed him behaving erratically. His family and personal medical history are not relevant. Upon admission, he is found with a body temperature of 38.6°C (101.5°F), and physical examination is unremarkable except for neck pain and fixed lateral flexion of the neck. He is confused, but there are no motor or sensory deficits. Deep tendon reflexes are accentuated. Magnetic resonance imaging of the brain shows leptomeningeal and gyral enhancement. Which of the following explains this patient’s condition?

Question: Which of the following explains this patient’s condition?

Answer: Viral infection


Context: A 36-year-old software professional consults a physician to discuss his concerns about small-vessel vasculitis as his mother and sister both have autoimmune small-vessel vasculitides. He has read about vasculitides and recently he came across an article which stated that an analgesic that he often uses for relief from a headache can cause small-vessel vasculitis. Due to his positive family history, he is especially concerned about his risk of developing small-vessel vasculitis. Which of the following clinical presentations is most likely to occur in this man?

Question: Which of the following clinical presentations is most likely to occur in this man?

Answer: Palpable purpura


Context: A 22-year-old man with no significant medical history presents with a two day history of bilateral eye redness, irritation, and watery mucous discharge as seen in the photograph provided. He has crusting of his eyes in the mornings without adhesion of his eyelids. He does not wear contact lenses and has had a sore throat the last three days. On physical exam, a left preauricular lymph node is enlarged and tender. An ophthalmologic exam reveals no additional abnormalities. Which of the following is the most appropriate treatment for this patient?

Question: Which of the following is the most appropriate treatment for this patient?

Answer: Warm compresses


Context:
A 58-year-old man with an unknown previous medical history is found on the floor at home by his daughter. During the initial assessment, the patient has right-sided arm weakness and incomprehensible speech. The patient is admitted to the hospital where he is diagnosed with an ischemic stroke where his magnetic resonance image (MRI) scan showed diffusion restriction in the right middle cerebral artery (MCA) territory. Further evaluation reveals the patient had been on the floor for about 2 days before he was found by his daughter. At presentation to the hospital, the blood pressure is 161/88 mm Hg and the heart rate is 104/min and regular. His laboratory values at the time of admission are shown:
BUN 40 mg/dL
Creatinine 1.9 mg/dL
Potassium 5.3 mEq/dL
Sodium 155 mEq/dL
Chloride 100 mEq/dL
HCO3 24 mmol/L
Hemoglobin 13.8 g/dL
Hematocrit 40%
Leukocytes 11,000/mL
Platelets 300,000/µL
Serum creatine kinase 40,000 U/L
Which of the following is most indicated in this patient?

Question:
His laboratory values at the time of admission are shown:
BUN 40 mg/dL
Creatinine 1.9 mg/dL
Potassium 5.3 mEq/dL
Sodium 155 mEq/dL
Chloride 100 mEq/dL
HCO3 24 mmol/L
Hemoglobin 13.8 g/dL
Hematocrit 40%
Leukocytes 11,000/mL
Platelets 300,000/µL
Serum creatine kinase 40,000 U/L
Which of the following is most indicated in this patient?

Answer: Forced diuresis with intravenous (IV) fluids


Context: A 16-year-old girl is brought to the emergency department by her parents because of fever, vomiting, rash, and worsening confusion since this morning. On questioning, her mother reports that her last menstrual period was 1 week ago and that she recently started using tampons. She appears lethargic and is only oriented to person. Her temperature is 40.4°C (104.7°F), pulse 174/minute, and blood pressure is 62/44 mm Hg. Examination shows oropharyngeal hyperemia and diffuse macular erythroderma. Which of the following is the most likely cause of this patient's condition?

Question: Which of the following is the most likely cause of this patient's condition?

Answer: Polyclonal T cell activation


Context: A 27-year-old man is brought to the emergency department after a motor vehicle accident. He complains of tingling of his legs, and he is unable to move them. His temperature is 36.5°C (97.7°F), the blood pressure is 110/75 mm Hg, and the pulse is 88/min. On physical examination, pinprick sensation is absent below the umbilicus and there is no rectal tone. Muscle strength in the lower extremities is 1/5 bilaterally. He has 5/5 strength in his bilateral upper extremities. Plain films and computerized tomography (CT) show the displacement of the lumbar vertebrae. Which of the following is the best next step in the management of this patient?

Question: Which of the following is the best next step in the management of this patient?

Answer: Intravenous methylprednisolone


Context: A 40-year-old Indian female is hospitalized with exertional dyspnea and lower extremity edema. The patient immigrated to the United States at age 15 and does not use tobacco, alcohol, or drugs. A mid-diastolic murmur is present and heard best at the apex. Which of the following symptoms would be most consistent with the rest of the patient’s presentation?

Question: Which of the following symptoms would be most consistent with the rest of the patient’s presentation?

Answer: Hoarseness


Context: A 14-year-old Caucasian girl presents to the pediatrician for poor balance. She reports a 7-month history of frequent falls that has progressively worsened. She has fallen 3 times in the past week and feels like she cannot walk normally. She was born full-term and spent 2 days in the neonatal intensive care unit for respiratory distress. She has had an otherwise normal childhood. Her family history is notable for multiple cardiac deaths before the age of 60. Her mother had a posterior spinal fusion for kyphoscoliosis as an adolescent. On exam, the patient has 4/5 strength in her bilateral upper and lower extremities. She walks with a staggering gait. Pes cavus is appreciated bilaterally. Skin examination is normal. This patient has a condition that is caused by a trinucleotide repeat of which of the following nucleotides?

Question: This patient has a condition that is caused by a trinucleotide repeat of which of the following nucleotides?

Answer: GAA


Context:
A 47-year-old farmer presents to his primary care physician for the first time appointment. The patient has never seen a doctor and states that he is in good health. He has worked as a farmer for the past 30 years and has no complaints. His temperature is 98.9°F (37.2°C), blood pressure is 197/118 mmHg, pulse is 90/min, respirations are 14/min, and oxygen saturation is 98% on room air. Physical exam is notable for an obese man in no current distress. Laboratory values are seen below.

Serum:
Na+: 139 mEq/L
Cl-: 101 mEq/L
K+: 5.2 mEq/L
HCO3-: 25 mEq/L
BUN: 34 mg/dL
Glucose: 179 mg/dL
Creatinine: 2.1 mg/dL
Ca2+: 10.2 mg/dL

Which of the following is the best management of this patient's blood pressure?

Question:
Serum:
Na+: 139 mEq/L
Cl-: 101 mEq/L
K+: 5.2 mEq/L
HCO3-: 25 mEq/L
BUN: 34 mg/dL
Glucose: 179 mg/dL
Creatinine: 2.1 mg/dL
Ca2+: 10.2 mg/dL

Which of the following is the best management of this patient's blood pressure?

Answer: Lisinopril


Context:
A 26-year-old woman presents to the office complaining of bloating and consistent fatigue. Past medical notes on her record show that she has seen several doctors at the clinic in the past year for the same concerns. During the discussion, she admits that coming to the doctor intensifies her anxiety and she does not enjoy it. However, she came because she fears that she has colon cancer and says, “There’s gotta be something wrong with me, I can feel it.” Past medical history is significant for obsessive-compulsive disorder (OCD). She sees a therapist a few times a month. Her grandfather died of colon cancer at 75. Today, her blood pressure is 120/80 mm Hg, heart rate is 90/min, respiratory rate is 18/min, and temperature is 37.0°C (98.6°F). Physical examination reveals a well-nourished, well-developed woman who appears anxious and tired. Her heart has a regular rhythm and her lungs are clear to auscultation bilaterally. Her abdomen is soft, non-tender, and non-distended. No masses are palpated, and a digital rectal examination is unremarkable. Laboratory results are as follows:
Serum chemistry
Hemoglobin 13 g/dL
Hematocrit
38%
MCV 90 fl
TSH
4.1 μU/mL
Fecal occult blood test  negative
Which of the following is the most likely diagnosis?

Question:
Laboratory results are as follows:
Serum chemistry
Hemoglobin 13 g/dL
Hematocrit
38%
MCV 90 fl
TSH
4.1 μU/mL
Fecal occult blood test  negative
Which of the following is the most likely diagnosis?

Answer: Illness anxiety disorder


Context: A 45-year-old man presents to his primary care physician for lower extremity pain and unsteadiness. He describes the pain as severe and stabbing and affecting his lower extremities. These episodes of pain last for minutes at a time. He also reports knocking into furniture regularly. Medical history is significant for streptococcal pharyngitis, where he had a severe allergic reaction to appropriate treatment. He is currently sexually active with men and does not use condoms. On physical exam, his pupils are miotic in normal and low light. The pupils do not constrict further when exposed to the penlight and there is no direct or consensual pupillary dilation when the penlight is removed. The pupils constrict further when exposed to a near object. He has decreased vibration and proprioception sense in his lower extremities, absent lower extremity deep tendon reflexes, and a positive Romberg test. Which of the following is the best next step in management?

Question: Which of the following is the best next step in management?

Answer: Intravenous penicillin


Context: A 25-year-old male wrestler presents to his primary care physician for knee pain. He was in a wrestling match yesterday when he was abruptly taken down. Since then, he has had pain in his left knee. The patient states that at times it feels as if his knee locks as he moves it. The patient has a past medical history of anabolic steroid abuse; however, he claims to no longer be using them. His current medications include NSAIDs as needed for minor injuries from participating in sports. On physical exam, you note medial joint tenderness of the patient’s left knee, as well as some erythema and bruising. The patient has an antalgic gait as you observe him walking. Passive range of motion reveals a subtle clicking of the joint. There is absent anterior displacement of the tibia relative to the femur on an anterior drawer test. The rest of the physical exam, including examination of the contralateral knee is within normal limits. Which of the following structures is most likely damaged in this patient?

Question: Which of the following structures is most likely damaged in this patient?

Answer: Medial meniscus


Context: A 71-year-old woman comes to the physician because of progressive shortness of breath and swollen legs for 4 weeks. She has tried sleeping in a raised position using 2 pillows but still wakes up occasionally from a choking sensation. She returned from a safari tour in Tanzania 3 months ago. She has type 2 diabetes mellitus, arterial hypertension, and gastroesophageal reflux disease. Her sister has polymyalgia rheumatica. Her current medications include insulin, enalapril, and omeprazole. She has smoked one half-pack of cigarettes daily for 45 years. Her temperature is 37°C (98.6°F), pulse is 112/min, respirations are 22/min, and blood pressure is 119/76 mm Hg. Pulse oximetry on room air shows an oxygen saturation of 90%. Examination shows pitting edema below the knees and jugular venous distention. Crackles are heard at both lung bases. A photograph of her tongue is shown. Her hemoglobin concentration is 10.0 g/dL, leukocyte count is 6,100/mm3, and erythrocyte sedimentation rate is 62 mm/h. ECG shows sinus rhythm and low-voltage QRS complexes. Echocardiography shows symmetrical left ventricular hypertrophy, reduced diastolic filling, and an ejection fraction of 55%. Which of the following is the most likely cause of this patient's symptoms?

Question: Which of the following is the most likely cause of this patient's symptoms?

Answer: Multiple myeloma


Context: A 6-year-old boy is brought to the pediatrician by his mother for diarrhea and a skin rash. His mother reports that he had a cough, sore throat, and runny nose 1 week ago. Although his upper respiratory symptoms improved after two days, he started having multiple watery bowel movements 3 days ago. He also developed a red pruritic rash on his arms, legs, and neck at that time. His mother also reports that he has had similar symptoms in the past that have occurred after the boy gets sick. His temperature is 98.8°F (37.1°C), blood pressure is 109/68 mmHg, pulse is 92/min, and respirations are 19/min. The child is alert and oriented to person but not place or time. He is unable to count to 10 even though his mother says he can normally count to 100 easily. He walks with a wide-based gait. An erythematous patchy rash is noted on his upper and lower extremities bilaterally. A complete blood count and basic metabolic panel are within normal limits. A urinalysis reveals elevated levels of neutral amino acids. Which of the following is the most appropriate acute treatment for this patient?

Question: Which of the following is the most appropriate acute treatment for this patient?

Answer: Nicotinic acid


Context: A 49-year-old man comes to the physician because of a 5-month history of progressive fatigue and exertional dyspnea. Cardiac examination shows a loud S2 in the 2nd left intercostal space. Right heart catheterization shows a pulmonary artery pressure of 32 mm Hg. Treatment with bosentan is initiated. The beneficial effect of this drug is due to binding to which of the following?

Question: The beneficial effect of this drug is due to binding to which of the following?

Answer: Endothelin receptors


Context: A 2-week-old newborn girl is brought to the physician for a follow-up examination after the initial newborn examination showed asymmetry of the legs. She was born at term to a 26-year-old woman, gravida 3, para 2. Pregnancy was complicated by a breech presentation and treated with an emergency lower-segment transverse cesarean section. The newborn's head circumference is 35 cm (13.7 in). She is at the 60th percentile for length and 75th percentile for weight. Cardiac examination shows no abnormalities. The spine and overlying skin do not indicate significant abnormalities. Abduction of the right hip after cupping the pelvis and flexing the right hip and knee causes a palpable clunk. The feet exhibit no deformities. Ultrasonography of the hip revealed a 50° angle between the lines along the bone acetabulum and the ilium. Which of the following is the most appropriate next step in management?

Question: Which of the following is the most appropriate next step in management?

Answer: Treat using a harness


Context: A 26-year-old woman comes to the physician because of a progressive swelling in her mouth that she first noticed 5 years ago. Initially, the swelling was asymptomatic but has now caused some difficulty while chewing food for the past month. She has no pain. She has not undergone any dental procedures in the past 5 years. She has bronchial asthma. Her only medication is an albuterol inhaler. She appears healthy. Her temperature is 37°C (98.6°F), pulse is 70/min, and blood pressure is 110/70 mm Hg. Examination shows a 1.5-cm smooth, unilobular, bony hard, nontender mass in the midline of the hard palate. There is no cervical or submandibular lymphadenopathy. The remainder of the examination shows no abnormalities. Which of the following is the most likely diagnosis?

Question: Which of the following is the most likely diagnosis?

Answer:
Torus palatinus
"


Context: A 54-year-old man presents to the emergency department after vomiting blood an hour ago. He says this happens to him occasionally but denies feeling pain in these episodes. The man is disheveled and has slurred speech as he describes his symptoms. He is reluctant to give further history and wants immediate treatment of his condition. Upon examination, the patient has evidence of tortuous veins visible on his abdomen plus a yellow tinge to his sclerae. He suddenly begins vomiting copious amounts of blood and soon becomes unresponsive. His blood pressure drops to 70/40 mm Hg. He is given 3 units of whole blood but passes away shortly after the incident. Which of the following was the most likely cause of his vomiting of blood?

Question: Which of the following was the most likely cause of his vomiting of blood?

Answer: Increased pressure in the distal esophageal vein due to increased pressure in the left gastric vein


Context: A 60-year-old man is brought to the emergency room because of fever and increasing confusion for the past 2 days. He has paranoid schizophrenia treated with chlorpromazine. He appears diaphoretic. His temperature is 40°C (104°F), pulse is 130/min, respirations are 29/min, and blood pressure is 155/100 mm Hg. Neurologic examination shows psychomotor agitation and incoherent speech. There is generalized muscle rigidity. His deep tendon reflexes are decreased bilaterally. Serum laboratory analysis shows a leukocyte count of 11,300/mm3 and serum creatine kinase concentration of 833 U/L. The most appropriate drug for this patient acts by inhibiting which of the following?

Question: The most appropriate drug for this patient acts by inhibiting which of the following?

Answer: Ryanodine receptor on the sarcoplasmic reticulum


Context: A 10-month-old infant is brought to the emergency by his parents after a seizure. The parents report no history of trauma, fever, or a family history of seizures. However, they both say that the patient fell while he was running. Neurologic examination was normal. A head CT scan was ordered and is shown in figure A. Which of the following is most likely found in this patient?

Question: Which of the following is most likely found in this patient?

Answer: Retinal hemorrhages


Context: An 80-year-old woman presents to her cardiologist for a scheduled appointment. She was shown to have moderate atrial dilation on echocardiography 3 years ago and was started on oral medications. The patient insists that she does not want aggressive treatment because she wants her remaining years to be peaceful. She has not been compliant with her medications and declines further investigations. Her heart rate today is 124/min and irregular. Which of the following organs is least likely to be affected by complications of her condition if she declines further management?

Question: Which of the following organs is least likely to be affected by complications of her condition if she declines further management?

Answer: Liver


Context: A 3-year-old girl is brought in by her parents to her pediatrician for concerns about their child’s behavior. Since the parents started taking their child to daycare, they have become concerned that their daughter has not been behaving like other children her age. Most notably, she seldom responds when her name is called at home or at daycare. Additionally, she has been getting in trouble with the day care staff for not following directions but instead demanding to play with the train set at all times. She has been asked numerous times to share the toys, but the patient does not play with the other children. The parents state that the patient was born vaginally following a normal pregnancy, and the patient had been meeting developmental milestones all along. While she does not speak much, she is able to construct sentences up to 4-5 words. On exam, the patient’s temperature is 98.2°F (36.8°C), blood pressure is 106/60 mmHg, pulse is 76/min, and respirations are 14/min. The patient does not cooperate with gross or fine motor testing, but she appears to have no trouble running around the room and draws very detailed trains with crayons. While drawing and standing, she frequently makes flapping motions with her hands. The patient has ample vocabulary, but speaks in a singsong voice mostly to herself and does not engage during the exam. Which of the following is the most likely diagnosis?

Question: Which of the following is the most likely diagnosis?

Answer: Autism spectrum disorder


Context: A 27-year-old man comes to the physician because of multiple, dry, scaly lesions on his elbows. The lesions appeared 4 months ago and have progressively increased in size. They are itchy and bleed when he scratches them. There is no associated pain or discharge. He was diagnosed with HIV infection 6 years ago. He has smoked a pack of cigarettes daily for the past 10 years. Current medications include raltegravir, lamivudine, abacavir, and cotrimoxazole. An image of the lesions is shown. His CD4+ T-lymphocyte count is 470/mm3 (normal ≥ 500). Which of the following is the most likely cause of this patient's skin findings?

Question: Which of the following is the most likely cause of this patient's skin findings?

Answer: Increased keratinocyte proliferation


Context: A 45-year-old African-American woman presents with dyspnea, cough, and non-radiating chest pain. Her chest pain is relieved by leaning forward and worsens upon leaning backwards. A scratchy rub is heard best with the patient leaning forward. Physical examination did not elucidate evidence of a positive Kussmaul's sign, pulsus paradoxus, or pericardial knock. The patient most likely is suffering from which of the following?

Question: The patient most likely is suffering from which of the following?

Answer: Acute pericarditis


Context: Shortly after the removal of a subclavian venous catheter by a surgical resident in an academic medical center, a 50-year-old man develops tachycardia, respiratory distress, and hypotension. Despite appropriate lifesaving treatment, the patient dies. Examination of the lungs during autopsy shows air in the main pulmonary artery. A root cause analysis is performed to prevent similar events occurring in the future. Which of the following actions is a primary approach for this type of error analysis?

Question: Which of the following actions is a primary approach for this type of error analysis?

Answer: Conduct interviews with all staff members involved in the patient's care


Context: A 63-year-old woman comes to the physician because of a skin lesion on her neck for 7 months. It is neither pruritic nor painful. She has tried using over-the-counter topical medications, but none have helped. She has hypertension, hypothyroidism, and gastroesophageal reflux disease. Current medications include amlodipine, hydrochlorothiazide, levothyroxine, and pantoprazole. She is a farmer and lives with her two children. Her temperature is 37.7°C (98.8°F), pulse is 80/min, respirations are 15/min, and blood pressure is 128/84 mm Hg. Examination shows a 5-mm (0.2-in) nontender, indurated, nodular lesion with rolled-out edges on the anterolateral aspect of the neck. There is a central area of ulceration. There is no cervical lymphadenopathy. The lungs are clear to auscultation. Cardiac examination shows no abnormalities. In addition to dermoscopy, which of the following is the most appropriate next step in management?

Question: In addition to dermoscopy, which of the following is the most appropriate next step in management?

Answer: Perform an excisional biopsy of the entire lesion


Context: A 45-year-old man comes to the physician for a follow-up examination after being diagnosed with hypertension 6 months ago. He has cut salt out of his diet and started exercising regularly, but home blood pressure measurements continue to be elevated. His blood pressure is 160/85 mm Hg. An antihypertensive medication is prescribed that decreases blood pressure by decreasing the transmembrane calcium current across vascular smooth muscle cells. Side effects include peripheral edema and flushing. Which of the following best describes why this drug does not affect skeletal muscle contraction?

Question: Which of the following best describes why this drug does not affect skeletal muscle contraction?

Answer: Skeletal muscle contraction occurs independently of extracellular calcium influx