We stay at the Artisan at least once a year just to do something outside of the house....love the decor in the lobby (various well-known paintings) and the bar (a multitude of mirrors all different sizes and shapes cover the ceiling).  Each room is themed with a different artist's paintings.  If you prefer the huge rooms of the Venetian or Ceasar's, this is not the place for you - it's guest rooms are standard hotel size, but it's the decor that sets them apart.  Also, if you'd like a suite to have a few friends over for a laid back get-together, the Artisan does have a smallish, similarly decorated suite with a pool table available for half the cost of the huge suites on the Strip.  I also remember the music out by the pool being particularly good - despite the pool being kinda between overpasses, they did a nice job with it and the cabanas.  Oh!  And the food in the restaurant was great!  The only negatives I can possibly think of would be room size and that you HAVE to valet park.