user19559: I've tried to copy CH340G from other schematics and existing Arduino Uno Clones... 
Searched online & StackExchange but no good :/ My problem is almost the same as this one
Here is my schematic

I can read & send data from the serial monitor

OS: Win 10 64 Bit 
USB Driver: 3.5.2019.1 

Upload Options:

Arduino IDE version: 1.8.12 
Board: Arduino Uno (also tired nano & nano old bootloader options)

What I've tried:

With & without the driver
Rebooted the computer
Tried different ports
Different cables
In case of IC not working, I've desoldered IC from working UNO
Changed RX, TX vice versa
Without R1 & R2
Different capacitors on C6 and C3
Buuut results are always the same as below

avrdude: Version 6.3-20190619
         Copyright (c) 2000-2005 Brian Dean, http://www.bdmicro.com/
         Copyright (c) 2007-2014 Joerg Wunsch

         System wide configuration file is "C:\Program Files (x86)\Arduino\hardware\tools\avr/etc/avrdude.conf"

         Using Port                    : COM3
         Using Programmer              : arduino
         Overriding Baud Rate          : 115200
avrdude: stk500_recv(): programmer is not responding
avrdude: stk500_getsync() attempt 1 of 10: not in sync: resp=0xf3
avrdude: stk500_recv(): programmer is not responding
avrdude: stk500_getsync() attempt 2 of 10: not in sync: resp=0xf3
avrdude: stk500_recv(): programmer is not responding
avrdude: stk500_getsync() attempt 3 of 10: not in sync: resp=0xf3
avrdude: stk500_recv(): programmer is not responding
avrdude: stk500_getsync() attempt 4 of 10: not in sync: resp=0xf3
avrdude: stk500_recv(): programmer is not responding
avrdude: stk500_getsync() attempt 5 of 10: not in sync: resp=0xf3
avrdude: stk500_recv(): programmer is not responding
avrdude: stk500_getsync() attempt 6 of 10: not in sync: resp=0xf3
avrdude: stk500_recv(): programmer is not responding
avrdude: stk500_getsync() attempt 7 of 10: not in sync: resp=0xf3
avrdude: stk500_recv(): programmer is not responding
avrdude: stk500_getsync() attempt 8 of 10: not in sync: resp=0xf3
avrdude: stk500_recv(): programmer is not responding
avrdude: stk500_getsync() attempt 9 of 10: not in sync: resp=0xf3
avrdude: stk500_recv(): programmer is not responding
avrdude: stk500_getsync() attempt 10 of 10: not in sync: resp=0xf3

avrdude done.  Thank you.

Problem uploading to board.  See http://www.arduino.cc/en/Guide/Troubleshooting#upload for suggestions.

I appreciate any help, idea, suggestion
Regards

user19559: The schematic is totally working. My mistake was after burning bootloader, I was uploading code via ISP. If you upload code via ISP, you're removing bootloader. 
Thank you everyone who helped me to I wasn't mistaken at schematic and else...

19559: <p>I've tried to copy CH340G from other schematics and existing Arduino Uno Clones... 
Searched online &amp; StackExchange but no good :/ My problem is almost the same as this one</p>

<p>Here is my schematic</p>

<p><a href="https://i.stack.imgur.com/KnsKI.png" rel="nofollow noreferrer"><img src="https://i.stack.imgur.com/KnsKI.png" alt="Schematics"></a></p>

<p>I can read &amp; send data from the serial monitor</p>

<ul>
<li>OS: Win 10 64 Bit </li>
<li>USB Driver: 3.5.2019.1 </li>
</ul>

<p><strong>Upload Options:</strong></p>

<ul>
<li>Arduino IDE version: 1.8.12 </li>
<li>Board: Arduino Uno (<em>also tired nano &amp; nano old bootloader options</em>)</li>
</ul>

<p>What I've tried:</p>

<ul>
<li>With &amp; without the driver</li>
<li>Rebooted the computer</li>
<li>Tried different ports</li>
<li>Different cables</li>
<li>In case of IC not working, I've desoldered IC from working UNO</li>
<li>Changed RX, TX vice versa</li>
<li>Without R1 &amp; R2</li>
<li>Different capacitors on C6 and C3
Buuut results are always the same as below</li>
</ul>

<pre><code>avrdude: Version 6.3-20190619
         Copyright (c) 2000-2005 Brian Dean, http://www.bdmicro.com/
         Copyright (c) 2007-2014 Joerg Wunsch

         System wide configuration file is "C:\Program Files (x86)\Arduino\hardware\tools\avr/etc/avrdude.conf"

         Using Port                    : COM3
         Using Programmer              : arduino
         Overriding Baud Rate          : 115200
avrdude: stk500_recv(): programmer is not responding
avrdude: stk500_getsync() attempt 1 of 10: not in sync: resp=0xf3
avrdude: stk500_recv(): programmer is not responding
avrdude: stk500_getsync() attempt 2 of 10: not in sync: resp=0xf3
avrdude: stk500_recv(): programmer is not responding
avrdude: stk500_getsync() attempt 3 of 10: not in sync: resp=0xf3
avrdude: stk500_recv(): programmer is not responding
avrdude: stk500_getsync() attempt 4 of 10: not in sync: resp=0xf3
avrdude: stk500_recv(): programmer is not responding
avrdude: stk500_getsync() attempt 5 of 10: not in sync: resp=0xf3
avrdude: stk500_recv(): programmer is not responding
avrdude: stk500_getsync() attempt 6 of 10: not in sync: resp=0xf3
avrdude: stk500_recv(): programmer is not responding
avrdude: stk500_getsync() attempt 7 of 10: not in sync: resp=0xf3
avrdude: stk500_recv(): programmer is not responding
avrdude: stk500_getsync() attempt 8 of 10: not in sync: resp=0xf3
avrdude: stk500_recv(): programmer is not responding
avrdude: stk500_getsync() attempt 9 of 10: not in sync: resp=0xf3
avrdude: stk500_recv(): programmer is not responding
avrdude: stk500_getsync() attempt 10 of 10: not in sync: resp=0xf3

avrdude done.  Thank you.

Problem uploading to board.  See http://www.arduino.cc/en/Guide/Troubleshooting#upload for suggestions.
</code></pre>

<p>I appreciate any help, idea, suggestion
Regards</p>
 19559: <p>The schematic is totally working. My mistake was after burning bootloader, I was uploading code via ISP. If you upload code via ISP, you're removing bootloader. </p>

<p>Thank you everyone who helped me to I wasn't mistaken at schematic and else...</p>
