text: user6539: what is the most optimal keyword search query to input into  NCBI In order to find all the available proteins accession numbers for a specific family? 
  For example, how would I find all the reviewed accession numbers for all currently available human ALDP (AdrenoLeukoDystrophy Protein) family of proteins that are in NCBI? 
  Also, is there a specific database within NCBI that is optimized for my task? 
  Thanks.
  
  user3577: A simple approach is to search for the gene name in NCBI Gene portal but this can miss a few cases and often include genes that are unrelated because the gene symbol is used by other unrelated genes as well. 
  For a cleaner dataset, you can use the NCBI Orthologs as follows. Search for human ALDP in the NCBI homepage with All Databases selected in the dropdown menu as shown below: 
  
  After you click the 'Search' button, you will be directed to a result page that looks like this: 
  
  Click on the 'Orthologs' button and you will be directed to a page with the list of proteins that are similar to the one you have started from. Note, these may not be orthologs in the truest sense; see this description about how they are calculated. 
  You can search for the taxonomic group that you are interested in, pick and choose the organisms of your interest and download the table in CSV format. It will have the NCBI GeneID, RNA and protein accessions. 
  
original_text: 6539: <p>what is the most optimal keyword search query to input into  NCBI In order to find all the available proteins accession numbers for a specific family? </p>
  
  <p>For example, how would I find all the reviewed accession numbers for all currently available human ALDP (AdrenoLeukoDystrophy Protein) family of proteins that are in NCBI? </p>
  
  <p>Also, is there a specific database within NCBI that is optimized for my task? </p>
  
  <p>Thanks.</p>
   3577: <p>A simple approach is to search for the gene name in <a href="https://www.ncbi.nlm.nih.gov/gene/?term=ALDP[name]" rel="nofollow noreferrer">NCBI Gene portal</a> but this can miss a few cases and often include genes that are unrelated because the gene symbol is used by other unrelated genes as well. </p>
  
  <p>For a cleaner dataset, you can use the NCBI Orthologs as follows. Search for <code>human ALDP</code> in the NCBI homepage with <code>All Databases</code> selected in the dropdown menu as shown below: </p>
  
  <p><a href="https://i.stack.imgur.com/GGcbA.png" rel="nofollow noreferrer"><img src="https://i.stack.imgur.com/GGcbA.png" alt="enter image description here"></a></p>
  
  <p>After you click the 'Search' button, you will be directed to a <a href="https://www.ncbi.nlm.nih.gov/search/all/?term=human%20ALDP" rel="nofollow noreferrer">result page</a> that looks like this: </p>
  
  <p><a href="https://i.stack.imgur.com/3dJvD.png" rel="nofollow noreferrer"><img src="https://i.stack.imgur.com/3dJvD.png" alt="enter image description here"></a></p>
  
  <p>Click on the 'Orthologs' button and you will be directed to a <a href="https://www.ncbi.nlm.nih.gov/gene/215/ortholog/?scope=117570" rel="nofollow noreferrer">page</a> with the list of proteins that are similar to the one you have started from. Note, these may not be orthologs in the truest sense; see this <a href="https://www.ncbi.nlm.nih.gov/kis/info/how-are-orthologs-calculated/" rel="nofollow noreferrer">description</a> about how they are calculated. </p>
  
  <p>You can search for the taxonomic group that you are interested in, pick and choose the organisms of your interest and download the table in CSV format. It will have the NCBI GeneID, RNA and protein accessions. </p>
  