text: user4595: I am working on cancer genomics failed to follow some terms even by googling 
  What is the difference of focal genome amplifications versus convergent amplification of given region of genome for instance fibroblast growth factors region?
  Thank you for any clarification 
  
  user3541: I think these definitions still have a degree of subjectivity and I don't think they are mutually exclusive.
  Convergent amplification basically means that "similar" cancers/neoplasms have "similar" amplification patterns, i.e. at around the same loci (see Myllykangas S et al.,2006 for an example).
  Focal genome amplification is defined as "CNA [copy number alteration] of limited size, frequently enriched for cancer driver genes" (Krijgsmanthis et al., 2014).
  
original_text: 4595: <p>I am working on cancer genomics failed to follow some terms even by googling </p>
  
  <p>What is the difference of <strong><em>focal genome amplifications</em></strong> versus <strong><em>convergent amplification</em></strong> of given region of genome for instance fibroblast growth factors region?</p>
  
  <p>Thank you for any clarification </p>
   3541: <p>I think these definitions still have a degree of subjectivity and I don't think they are mutually exclusive.</p>
  
  <p>Convergent amplification basically means that "similar" cancers/neoplasms have "similar" amplification patterns, i.e. at around the same loci (see <a href="https://www.ncbi.nlm.nih.gov/pubmed/16751803" rel="nofollow noreferrer">Myllykangas S et al.,2006</a> for an example).</p>
  
  <p>Focal genome amplification is defined as "CNA [copy number alteration] of limited size, frequently enriched for cancer driver genes" (<a href="https://www.sciencedirect.com/science/article/pii/S0167488914003000?via%3Dihub" rel="nofollow noreferrer">Krijgsmanthis et al., 2014</a>).</p>
  