text: user12603: The R package limma is ideal to perform differential expression analysis. Is there any limma alternative in Python?
  I'm trying to use statsmodels and scikitlearn in conjunction with some other cool tools (such as pycombat) to get limma-like workflows. However, I'm missing many capabilities from the limma toolbox.
  
  user12603: August 2021
  To date, it seems that the response to this question is "No". However, there is a GitHub repository called edgePy, aiming to "become an implementation of edgeR for differential expression analysis in the Python language" (edgeR is somewhat similar to limma).
  PS: Many thanks to @ATpoint90 (the Twitter "hive mind" summoner) and @sridnona6 (edgePy developer).
  
original_text: 12603: <p>The R package <a href="https://bioconductor.org/packages/release/bioc/html/limma.html" rel="nofollow noreferrer"><code>limma</code></a> is ideal to perform differential expression analysis. Is there any <code>limma</code> alternative in Python?</p>
  <p>I'm trying to use <a href="https://www.statsmodels.org/stable/index.html" rel="nofollow noreferrer"><code>statsmodels</code></a> and <a href="https://scikit-learn.org/stable/" rel="nofollow noreferrer"><code>scikitlearn</code></a> in conjunction with some other cool tools (such as <a href="https://github.com/epigenelabs/pyComBat" rel="nofollow noreferrer"><code>pycombat</code></a>) to get <code>limma</code>-like workflows. However, I'm missing many capabilities from the <code>limma</code> toolbox.</p>
   12603: <p><strong>August 2021</strong></p>
  <p>To date, it seems that the response to this question is <strong>&quot;No&quot;</strong>. However, there is a GitHub repository called <a href="https://github.com/r-bioinformatics/edgePy" rel="nofollow noreferrer"><code>edgePy</code></a>, aiming to <em>&quot;become an implementation of <a href="https://bioconductor.org/packages/release/bioc/html/edgeR.html" rel="nofollow noreferrer"><code>edgeR</code></a> for differential expression analysis in the Python language&quot;</em> (<code>edgeR</code> is somewhat similar to <code>limma</code>).</p>
  <p>PS: Many thanks to @ATpoint90 (the Twitter <a href="https://twitter.com/ATpoint90/status/1423669033702940678" rel="nofollow noreferrer">&quot;hive mind&quot; summoner</a>) and @sridnona6 (<code>edgePy</code> developer).</p>
  