text: user3171: 
  Did anyone know how to find the differential expressed genes within pseudotime trajectory with Seurat cluster? In monocle tutorial, we can use BEAM to find the differential expressed genes between the two branches even with the states difference. But how can I find the differential expressed genes with seurat culster enven with the genotype diffence? Thank you so much!
  
  user-1: You probably want approaches such as tradeSeq.
  For Seurat to tradeSeq see also this issue.
  
original_text: 3171: <p><a href="https://i.stack.imgur.com/vr0D4.jpg" rel="nofollow noreferrer"><img src="https://i.stack.imgur.com/vr0D4.jpg" alt="enter image description here" /></a></p>
  <p>Did anyone know how to find the differential expressed genes within pseudotime trajectory with Seurat cluster? In monocle tutorial, we can use BEAM to find the differential expressed genes between the two branches even with the states difference. But how can I find the differential expressed genes with seurat culster enven with the genotype diffence? Thank you so much!</p>
   -1: <p>You probably want approaches such as <a href="https://bioconductor.org/packages/release/bioc/html/tradeSeq.html" rel="nofollow noreferrer">tradeSeq</a>.</p>
  <p>For Seurat to tradeSeq see also this <a href="https://github.com/statOmics/tradeSeq/issues/45" rel="nofollow noreferrer">issue</a>.</p>
  