text: user4660: Using Biojava 5, I am trying to convert a sequence of Amino Acids to a Nucleotide sequence. Any idea how to do this?
  
  user9534: Note that unlike the reverse (nucleotide sequence to protein sequence), which is uniquely defined given a reading frame, the mapping from protein sequence to nucleotide sequence is not unique (it is not a function in the mathematical sense). The method you use to select which of the many (exponential in input sequence length) possible sequences to output depends critically on what the question is.
  If the goal is to design a synthetic gene that will produce a desired protein, then you need to optimize it for expression in the organism into which the gene will be inserted, subject to the constraint of the encoded amino acid sequence.
  If the goal is to search for nucleotide sequences in one or more genomes that could give rise to a certain polypeptide, there is a much better way than to do reverse translation at all. In particular, most putative protein-coding open reading frames in most sequenced genomes have already been run through forward translation code and the expected amino acid sequence encoded in them can be found in databases. So, this problem is reduced to a substring search in these databases.
  
original_text: 4660: <p>Using Biojava 5, I am trying to convert a sequence of Amino Acids to a Nucleotide sequence. Any idea how to do this?</p>
   9534: <p>Note that unlike the reverse (nucleotide sequence to protein sequence), which is uniquely defined given a reading frame, the mapping from protein sequence to nucleotide sequence is not unique (it is not a function in the mathematical sense). The method you use to select which of the many (exponential in input sequence length) possible sequences to output depends critically on what the question is.</p>
  <p>If the goal is to design a synthetic gene that will produce a desired protein, then you need to optimize it for expression in the organism into which the gene will be inserted, subject to the constraint of the encoded amino acid sequence.</p>
  <p>If the goal is to search for nucleotide sequences in one or more genomes that could give rise to a certain polypeptide, there is a much better way than to do reverse translation at all. In particular, most putative protein-coding open reading frames in most sequenced genomes have already been run through forward translation code and the expected amino acid sequence encoded in them can be found in databases. So, this problem is reduced to a substring search in these databases.</p>
  