text: user1082: Can anyone help me explain what allelic imbalance is, hopefully shortly? 
  Surprisingly, we cannot find any introduction online. 
  
  user3624: It might be used differently in different contexts, but generally speaking, in my world - allelic imbalance is when there's a difference in the level of gene expression from different alleles, usually through genetic (e.g. a variant in a promoter) or epigenetic mechanisms (e.g. one copy silenced, as in imprinted regions).
  There are a few blog posts here with some more information, and plenty of papers (google "Allelic imbalance") if you want to dig deeper.
  
original_text: 1082: <p>Can anyone help me explain what allelic imbalance is, hopefully shortly? 
  Surprisingly, we cannot find any introduction online. </p>
   3624: <p>It might be used differently in different contexts, but generally speaking, in my world - allelic imbalance is when there's a difference in the level of gene expression from different alleles, usually through genetic (e.g. a variant in a promoter) or epigenetic mechanisms (e.g. one copy silenced, as in imprinted regions).</p>
  
  <p>There are a <a href="http://nathansheffield.com/wordpress/what-is-allelic-imbalance/" rel="nofollow noreferrer">few</a> <a href="https://www.rna-seqblog.com/direct-testing-for-allele-specific-expression-differences-between-conditions/" rel="nofollow noreferrer">blog</a> posts here with some more information, and plenty of papers (google "Allelic imbalance") if you want to dig deeper.</p>
  