text: user5180: I am trying to perform de novo structure prediction of a 1135 long protein sequence; can DMPfold and I-Tasser work well for de novo structure prediction of 1135 amino acid long sequence?
  
  user4622: For DMPfold you might like to look at Figure 5B of the paper, which implies that performance starts to drop off after ~600 residues. Only proteins up to 500 residues were used in the training set, for example.
  A protein of that length is almost certainly multi-domain. I would consider doing domain prediction; we have a tool DomPred, but many others are available. Then run the sequences of the domains individually and recombine them later.
  I don't know about I-Tasser's ability to do this, perhaps see if they mention it in their papers.
  
original_text: 5180: <p>I am trying to perform de novo structure prediction of a 1135 long protein sequence; can DMPfold and I-Tasser work well for de novo structure prediction of 1135 amino acid long sequence?</p>
   4622: <p>For DMPfold you might like to look at Figure 5B of <a href="https://www.nature.com/articles/s41467-019-11994-0" rel="nofollow noreferrer">the paper</a>, which implies that performance starts to drop off after ~600 residues. Only proteins up to 500 residues were used in the training set, for example.</p>
  
  <p>A protein of that length is almost certainly multi-domain. I would consider doing domain prediction; we have a tool <a href="http://bioinf.cs.ucl.ac.uk/psipred" rel="nofollow noreferrer">DomPred</a>, but many others are available. Then run the sequences of the domains individually and recombine them later.</p>
  
  <p>I don't know about I-Tasser's ability to do this, perhaps see if they mention it in their papers.</p>
  