at least the under ten year old set will stay interested . eleanor ( geena davis ) and fred ( hugh laurie ) little and a nice well to do couple set out to bring home from the orphanage a new little brother for their son george ( johnathan lipnicki ) . they come home with quite the odd new sibling . a sharp dressed little mouse name stuart ( voice by michael j. fox ) . yes and mouse . stuart be happy to have find the sense of belong even if it be in a super size world that contain his new family pet cat snowbell ( voice by nathan lane ) . stuart embarks on the experience of family loyalty and overall friendship . george will finally accept his tiny new brother when the dapper dress stuart save embarrassment at a model boat race . also in the cast represent julia sweeney and harold gould and estelle getty and jeffery jones . and the voice of represent chaz palminteri and bruno kirby and jennifer tilly .