<s>[INST] My baby girl was born on 13th December 12. Her weights was 3.19 kgs. she was diagnosed with heart murmur by doctor. and doctor suggest me for ECO test. after ECO test he told me that my baby has 2 defects in heart. one is 7.5 mm (L R) secundeum interatrial septum defect and second is 5.2 mm (L R) Membrance interventricular septum defect. he told me it is minimum size of defect. so we needs to wait for 3 month and after that we will check it again. it could be fill automatically. so please tell is it possible to fill this hole without a operation [/INST] Hi, ASD >5 mm is significant and is unlikely to close spontaneously. The natural course of a VSD depends to a large degree on the size of the defect. A significant number (30–50%) of small defects close spontaneously, most frequently during the 1st 2 yr of life. Small muscular VSDs are more likely to close (up to 80%) than membranous VSDs are (up to 35%). The vast majority of defects that close do so before the age of 4 yr, although spontaneous closure has been reported in adults. Hope I have answered your query. Let me know if I can assist you further. Regards, Dr. Tushar Kanti Biswas, Internal Medicine Specialist </s>