<s>[INST] Hi my ALT and ALP have been elevated for several months, highest about 278, both currently at 143. I don t drink or smoke, but do over eat, very much a chocoholic, loving carbohydrates / sugary stuff. I have some fat in my liver and a 4mm gallbladder polyup. I m male 34 bout 5ft 8in height, bout 15 nearly 16 stone; so certainly overweight. Symptoms of severe lethargy have reduced as the serum levels have fallen, which may be drug related; reduced duloxetine down from 120mg per day to 90mg. Curious as to what the cause of the persistently elevated but reducing serum levels is. Can you shed some light? Thanks :) [/INST] Dear FriendI understy your concern.I am more worried about your raised liver enzymes.They should be evaluated.I advise you to get following investigation:1. HBsAg2. Anti HCV Antibody.3. Complete LFT.If no cause is found on these investigation s we will do workup for Non Alcoholic Fatty Liver Disease.Don't take the things lightly.There is definitely some problem.Stay Healthy. </s>