<s>[INST] My mother (65) has been taking Nexito-10 for a along time as per advice of Psychiatrist but recently she has been suffering from Parkinson disease as a result we conduct a medicine specialist who prescribed along with other medicine Propranol-40mg instead of Nexito-10. Please clear me is Propranol-40mg relief the mental problems of my mother? [/INST] Hello,Propranolol can not be substituted for nexito. And nexito is not contraindicated in in parkinson disease. Rather depression and parkinson occur togather commonly.So you must talk to your doctor about this.Thanks. </s>