<s>[INST] Hi, I have received back some blood test which appeared to be fairly ok....accept I noticed a test the doctor did not bring up that concerns me.  The Immunofixation Serum test states a faint 1gG Kappa monoclonal immunoglobulin is detected.  Should I be concerned?  I've not felt myself for a while and have a several cancer situations in my family in which two of my siblings passed. [/INST] Hi Now your concern is pretty genuine, I suppose that you do not any symptoms ,this IgG K could be Monoclonal gammapathy of unknown significanceyou should make sure that 1 a bone marrow is done2 your Hemogram and kidney function tests with serum ca is done3 please forward the value of Ig G band now if this is MGUS then there is 1 -2 % chance of progression to multiple myelomaall this but we neeed more details before diagnosing this condition Take care </s>