<s>[INST] My sister just informed me that she has been suffering from constant pain. It starts in her lower back, radiates up to the middle of her shoulder blade and then down her left side. She has paid on her left side and it will go numb at times. She often gets what she says is a knot that forms in her left upper arm (bicep) and she has to massage it out. She recently went the doctor and they have run MRI s and CT Scans...but they are unable to diagnose anything. They initially thought she had a stroke...but not now. She told me she is in constant pain...sometimes dull and sometimes intense. She does have Morphan Syndrome (sp?). Could this be a symptom? I asked if she had mentioned that to her doctor and she had not. [/INST] Hello, It is not a sign of Marfan syndrome. Most probably it’s due to spine related problems like a prolapsed disc or nerve compression. Consult an orthopedician and get evaluated. An MRI scan is required for further assessment. Hope I have answered your query. Let me know if I can assist you further. Regards, Dr. Shinas Hussain, General & Family Physician </s>