<s>[INST] I have a 11 yrs old girl. She is having intermittant stomach pain and we took treatment for liver. Recently sonography results indicate mild fluid collection in POD and mild enlargement of spleen. Does liver dysfunction affect in anyway the spleen. She is having still pain now. [/INST] Hi thanks for asking question.You have not mentioned which liver pathology is treated.Yes liver condition can affect spleen if portal hypertension present.So if any cryptogenic liver cirrhosis Like condition present then spleenomegaly with fluid collection can occur.Inflammation or infective condition also can lead fluid collection.Do her LFT , RFT as detail investigation.It might be helpful.ex.hypoalbumin can lead to edema and fluid collection.The detailed history and physical examination finding needed for further work up.Take care...Wish you good health. </s>