<s>[INST] I have Ehler-Danlos (hybermobile) type and now have an extremely high CRP rat 34.4 (I believe anything over 7 is a concern). I've had 4 shoulder replacements. My orthopedic surgeon aspirated some fluid from the joint/prosthesis and has ruled out an infection there. Now my familiy doctor doesn't seem concerned at all with a 34.4 CRP reading but I am! I am 53 years old and have a lot of other symptoms as well, but my main concern right now is that my extremely high CRP may indicate something that should be treated right away - like cancer or lupus. There have been no tests ordered and I feel very confused about how much I should push my doctor to investigate this. By the way, my CRP has been elevated from a shoulder infection prior -- then it was only at 12 -- now at 34.4 that seems very frightening to me. My high sensitivity CRP test put me in the "average" range for heart disease. Do you have any suggestions for me? [/INST] welcome to hcm ...high crp means that there is infection or inflammation ..as per aspiration your doctor could not find infection ..its good ..now crp may be raised in inflammatory conditions ..let the orthopaedic doctor treat condition ...crp will decrease with time  ...and second thing ..raised crp is one of the risk factor of cardiac disease but it is not the only factor ..so just relax </s>