<s>[INST] Hi Ive been prescribed motilium for my nausea & reflux which I ve had for about 8 months. I ve had a gastroscopy, Ct scan chest & stomach, barium swallow & colonoscopy all came up ok. I m also on warfarin (aortic valve replacement)& other meds. Im just wondering if I should b taking this with my heart condition? Any advice please as I m getting very confused & anxious . Also a recent blood test came back as highly probable for celiac disease. I ve been Gluten free for 4 weeks today & still feel nauseous intermittently. Help please [/INST] Hello and Welcome to ‘Ask A Doctor’ service. I have reviewed your query and here is my advice. I understand your concern and would explain that it is safe to take Domperidone concomitantly with warfarin and other drugs. But, you should know that this drug may lead to severe adverse effects on the heart (life QT prolongation syndrome, severe arrhythmia and acute cardiac death). For this reason, I would recommend periodically check up with a resting ECG every 2 months while taking this drug, just to be sure that everything is OK. Hope I have answered your query. Let me know if I can assist you further. </s>