<s>[INST] I have Follicular Lymphoma ( initially large cell follicular ) treated with R CHOP and put in remission for 3 years. Relapsed one year ago with follicular only and treated with Rituxan. Had a 3 month remission and than relapsed. Being treated again with Rituxan. Cancer returned to left side of neck and clavicle both relapses. However--I am now experiencing sciatic pain ( with no cause) could this be the lymphoma? 38 years old female [/INST] Hi,Follicular lymphoma is a indolent disease, so the patient leaves with a disease for a long duration. Although the involvement of bone is rare, it can involve any part of the body. You need to undergo MRI of the spine to see for the cause of sciatic pain.It may also give a clue if there is relapse of lymphoma to spine and bone scan also may show the uptake. The involvement of spine can be conformed only with biopsy of the lesion. With the presence of disease elsewhere in the body, biopsy of spine may not be required and requires treatment for lymphoma.Hope i have answered your question. </s>