<s>[INST] my father has a hypertension since 10 years &started amlodipine since 8 years before month ago he feels severe headache and his physician gave him cinazine and aspirin ,he is 62 yrs oll smoker ,aweek ago ,aperipheral edema in his legs I just want to know if there is any containdication especially that coth are vasodilators? [/INST] Hi, I understand your concern and would explain that both Cinnarizine and Amlodipine can lead to leg swelling. For this reason, I would not recommend taking them concomitantly as your father is experiencing this adverse effect. Hope I have answered your query. Let me know if I can assist you further. Regards, Dr. Ilir Sharka, Cardiologist </s>