<s>[INST] does the patch still be effective when it got very wrinkles and water gets into the wrinkles edge when showering? Would Miralax make the Evra patch less effective? I heard that if we have diarrhea while on the pill it would flush out the pill, but since the patch goes straight to the bloodstream, then does it mean I m still protected if throwing up or have diarrhea? Can I place the patch on my thigh in the back (under the buttock) and front? [/INST] the patch should be placed on your lower abdomen, chest (not breast), arm, upper back, or buttocks.  the thigh is not one of the approved places, so it may not work.you are correct that since it is not absorbed in the digestive tract, that diarrhea and miralax will not change it's' effectiveness.as long as it is still sticking on your skin it will work, but if the water washes it off you should replace it.I hope this answers your question, please let me know if you have any more questions. </s>