The end result of the war, a greatly reduced French presence on the American mainland, meant that Indians could no longer easily play the British and French off each other, which opened the floodgates of British settlers. In the end, the American Indians were perhaps the biggest losers of the Seven Years War. Thanks, Thought Bubble. So 2,000 miles south, in the Caribbean, there was also quite a lot of fighting between the British and the French over sugar colonies. Most of these were naval battles, and by 1761, Spain got involved because, you know, they had some sugar colonies of their own. While these battles get a lot of ink, it's interesting to note that by far the greatest threat to combatants was disease. By October of 1761, the British had lost about 1,000 men to war and 5,000 to disease.