One of the not-so-good things was the spread of disease. So in the historical record, we have two major plagues in Rome during the Roman Empire, and we believe these plagues were smallpox, although some people believe it might have been measles. And it is believed that it came from traders, it came from Asia, from the Middle East, and these were significant plagues. And the reason why we think that it was due to trade is that there's some evidence in Han China during this first plague of similar symptoms, of a similar plague. But it really affected Rome. In these plagues, it's estimated that as much as 10% of the population might have died. In certain cities, it might have been 25, 30% of the population.