Today we know that AHR / CYP1-signaling is involved in an amazing array of genetic networks and subcellular processes critical to lifesub production ; crosstalk with hypoxia and Hypoxia-inducible factors ( HIF ) -signaling pathways ; transforming growth factor -signaling pathways , as well as growth suppression ; tumor initiation ; tumor promotion ; transgenerational inheritance and epigenetic effects ; chromatin remodeling ; histone modification ; and aging-related and degenerative disease s .