The region of Assyria fell under the successive control of the Median Empire of 678 to 549 BC , the Achaemenid Empire of 550 to 330 BC , the Macedonian Empire ( late 4th century BC ) , the Seleucid Empire of 312 to 63 BC , the Parthian Empire of 247 BC to 224 AD , the Roman Empire ( from 116 to 118 AD ) and the Sasanian Empire of 224 to 651 AD .