Pathophysiology
https://openalex.org/C10162356
https://www.wikidata.org/wiki/Q1135939
Nitric oxide
https://openalex.org/C519581460
https://www.wikidata.org/wiki/Q207843
Pharmacology
https://openalex.org/C98274493
https://www.wikidata.org/wiki/Q128406
Medicine
https://openalex.org/C71924100
https://www.wikidata.org/wiki/Q11190
Chemistry
https://openalex.org/C185592680
https://www.wikidata.org/wiki/Q2329
Neuroscience
https://openalex.org/C169760540
https://www.wikidata.org/wiki/Q207011
Establising the importance of the topic as a problem to be addressed
X is a leading cause of …
[INST] Please produce a sentence from the paper. The sentence should not mention the title of the paper, rather it be extracted from the Introducing Work section of the paper.
Please provide one singular full sentence from the paper that serves the function provided, using the example as guidance. Be specific, using relevant terminology from the paper.
Refrain from vague or generic statements. Finally produce a search query in the form of a question targeted towards the knowledge contained therein. 
You must output json with the structure of {'Sentence': sentence, 'Query': query}.
Field: "Pharmacology".
Paper: "The tail suspension test: A new method for screening antidepressants in mice"
Function: "Establising the importance of the topic as a problem to be addressed".
Example Sentence: "X is a leading cause of …". [/INST]