Sam68 not only regulates the alternatve splicing of a number of cancer-related genes, but also interacts with splicing complex proteins KHDRBS3 (T-STAR) and Metadherin (involved in HIF-1alpha mediated angiogenesis), which also alter CD44 splicing.
Sam68 not only regulates the alternatve splicing of a number of cancer-related genes, but also interacts with splicing complex proteins KHDRBS3 (T-STAR) and Metadherin (involved in HIF-1alpha mediated angiogenesis), which also alter CD44 splicing.