The two regions responsible for oligomerization between HSF1 monomers (the primary mediator of transcriptional responses to proteotoxic stress) are leucine zipper (LZ) domains 1-3, situated just downstream of the DBD, and 4, located between the RD and the C-terminal TAD.
The two regions responsible for oligomerization between HSF1 monomers (the primary mediator of transcriptional responses to proteotoxic stress) are leucine zipper (LZ) domains 1-3, situated just downstream of the DBD, and 4, located between the RD and the C-terminal TAD.