pre mrna splicing occurs at the spliceosome in eukaryotes.
pre mrna splicing occurs at the spliceosome in eukaryotes.
where does pre mrna splicing occur in eukaryotes?
spliceosome
cdc40









































pre-mrna-processing factor 17 is a protein that in humans is encoded by the "cdc40" gene.









































pre-mrna splicing occurs in two sequential transesterification steps. the protein encoded by this gene is found to be essential for the catalytic step ii in pre-mrna splicing process. it is found in the spliceosome, and contains seven wd repeats, which function in protein-protein interactions. this protein has a sequence similarity to yeast prp17 protein, which functions in two different cellular processes: pre-mrna splicing and cell cycle progression. it suggests that this protein may play a role in cell cycle progression.
cdc40
exitrons are a result of alternative splicing (as), in which introns are typically cut out of a pre mrna sequence, while exons remain in the sequence and are translated into proteins. the same sequence within a pre mrna strand can be considered an intron or exon depending on the desired protein to be produced. as a result, different final mrna sequences are generated and a large variety of proteins can be made from one single gene. mutations that exist in these sequences can also alter the way in which a sequence is spliced and as a result, change the protein produced. splicing mutations of a mrna sequence has been found to account for 15-60% of human genetic diseases, which suggests there may be a crucial role of exitrons in organ homeostasis.
exitron