production of new bony matrix is by mesenchymal stem cells cell type.
production of new bony matrix is by mesenchymal stem cells cell type.
production of new bony matrix is by which cell type?
mesenchymal stem cells
although osteocytes have reduced synthetic activity and (like osteoblasts) are not capable of mitotic division, they are actively involved in the routine turnover of bony matrix, through various mechanosensory mechanisms. they destroy bone through a rapid, transient (relative to osteoclasts) mechanism called osteocytic osteolysis. hydroxyapatite, calcium carbonate and calcium phosphate is deposited around the cell.









































section::::structure.
osteocyte
dna methylation marks — genomic regions with specific methylation pattern in a specific biological state such as tissue, cell type, individual — are regarded as possible functional regions involved in gene transcriptional regulation. although various human cell types may have the same genome, these cells have different methylomes. the systematic identification and characterization of methylation marks across cell types are crucial to understanding the complex regulatory network for cell fate determination. hongbo liu et al. proposed an entropy-based framework termed smart to integrate the whole genome bisulfite sequencing methylomes across 42 human tissues/cells and identified 757,887 genome segments. nearly 75% of the segments showed uniform methylation across all cell types. from the remaining 25% of the segments, they identified cell type-specific hypo/hypermethylation marks that were specifically hypo/hypermethylated in a minority of cell types using a statistical approach and presented an atlas of the human methylation marks. further analysis revealed that the cell type-specific hypomethylation marks were enriched through h3k27ac and transcription factor binding sites in cell type-specific manner. in particular, they observed that the cell type-specific hypomethylation marks are associated with the cell type-specific super-enhancers that drive the expression of cell identity genes. this framework provides a complementary, functional annotation of the human genome and helps to elucidate the critical features and functions of cell type-specific hypomethylation.
dna methylation