antipsychotic drugs are also known by the two other names lsd.
antipsychotic drugs are also known by the two other names lsd.
antipsychotic drugs are also known by what two other names?
lsd
Na
Na
neurotensin has been implicated in the modulation of dopamine signaling, and produces a spectrum of pharmacological effects resembling those of antipsychotic drugs, leading to the suggestion that neurotensin may be an endogenous neuroleptic. neurotensin-deficient mice display defects in responses to several antipsychotic drugs consistent with the idea that neurotensin signaling is a key component underlying at least some antipsychotic drug actions. these mice exhibit modest defects in prepulse inhibition (ppi) of the startle reflex, a model that has been widely used to investigate antipsychotic drug action in animals. antipsychotic drug administration augments ppi under certain conditions. comparisons between normal and neurotensin-deficient mice revealed striking differences in the ability of different antipsychotic drugs to augment ppi. while the atypical antipsychotic drug clozapine augmented ppi normally in neurotensin-deficient mice, the conventional antipsychotic haloperidol and the newer atypical antipsychotic quetiapine were ineffective in these mice, in contrast to normal mice where these drugs significantly augmented ppi. these results suggest that certain antipsychotic drugs require neurotensin for at least some of their effects. neurotensin-deficient mice also display defects in striatal activation following haloperidol, but not clozapine administration in comparison to normal wild type mice, indicating that striatal neurotensin is required for the full spectrum of neuronal responses to a subset of antipsychotic drugs.
neurotensin