rad52 is involved in homologous recombinational repair type of dna damage repair.
rad52 is involved in homologous recombinational repair type of dna damage repair.
rad52 is involved in which type of dna damage repair?
homologous recombinational repair
human rad52 also has an important role in repair of dna double-strand breaks at active transcription sites during the g0/g1 phase of the cell cycle. repair of these double-strand breaks appears to use an rna template-based recombination mechanism dependent on rad52. the cockayne syndrome b protein (csb) (coded for by "ercc6") localizes at double-strand breaks at sites of active transcription, followed by rad51, rad51c and rad52 to carry out homologous recombinational repair using the newly synthesized rna as a template.









































section::::micrornas and cancer risk.
rad52
this gene product is highly similar to s. pombe rad9, a cell cycle checkpoint protein required for cell cycle arrest and dna damage repair in response to dna damage. this protein is found to possess 3' to 5' exonuclease activity, which may contribute to its role in sensing and repairing dna damage. it forms a checkpoint protein complex with rad1 and hus1. this is also known as the rad9-rad1-hus1 or 9-1-1 complex. this complex is recruited by checkpoint protein rad17 to the sites of dna damage, which is thought to be important for triggering the checkpoint-signaling cascade. use of alternative polya sites has been noted for this gene. this complex plays a role in dna base excision repair. hus1 binds and stimulates myh dna glycosylase which stimulates base excision repair. rad9 binds with the strongest affinity to dna which attaches the complex to damaged dna. rad1 recruits other base excision factors. previous research has suggested that rad9 is not necessary to repair dna, but it does not mean it can still play a role in dna damage repair. if rad9 is mutated there may be other pathways or mechanisms in dna repair that can compensate for a loss of function.
rad9a