the regulatory site of an enzyme is called allosteric site.
the regulatory site of an enzyme is called allosteric site.
which site of an enzyme is called allosteric site?
regulatory site
allosteric modulation is used to alter the activity of molecules and enzymes in biochemistry and pharmacology. for comparison, a typical drug is made to bind to the active site of an enzyme which thus prohibits binding of a substrate to that enzyme causing a decrease in enzyme activity. allosteric modulation occurs when an effector binds to an allosteric site (also known as a regulatory site) of an enzyme and alters the enzyme activity. allosteric modulators are designed to fit the allosteric site to cause a conformational change of the enzyme, in particular a change in the shape of the active site, which then causes a change in its activity. in contrast to typical drugs, modulators are not competitive inhibitors. they can be positive (activating) causing an increase of the enzyme activity or negative (inhibiting) causing a decrease of the enzyme activity. the use of allosteric modulation allows the control of the effects of specific enzyme activities; as a result, allosteric modulators are very effective in pharmacology.
allosteric regulation
2-epimerase converts udp-"n"-acetyl--glucosamine to udp-"n"-acetyl--mannosamine. bacterial 2-epimerase differs from its human counterpart in that the bacterial molecule has an allosteric site. for enzymatic activity, the allosteric site needs to be occupied by the substrate udp-"n"-acetylglucosamine; this is the first enzyme described in which the substrate is present in both the catalytic and allosteric sites. because epimerox targets the allosteric site of the bacterial 2-epimerase, low human toxicity is expected since the human 2-epimerase does not have this site.
epimerox