gonadotrophin-releasing hormone from the hypothalamus stimulates the anterior pituitary to release testosterone.
gonadotrophin-releasing hormone from the hypothalamus stimulates the anterior pituitary to release testosterone.
gonadotrophin-releasing hormone from the hypothalamus stimulates the anterior pituitary to release?
testosterone
aas consumption disrupts the hypothalamic–pituitary–gonadal axis (hpg axis) in males. in the hpg axis, gonadotropin-releasing hormone (gnrh) is secreted from the arcuate nucleus of the hypothalamus and stimulates the anterior pituitary to secrete the two gonadotropins, follicle stimulating hormone (fsh) and luteinizing hormone (lh). in adult males, lh stimulates the leydig cells in the testes to produce testosterone which is required to form new sperm through spermatogenesis. aas consumption leads to dose-dependent suppression of gonadotropin release through suppression of gnrh from the hypothalamus (long-loop mechanism) or from direct negative feedback on the anterior pituitary to inhibit gonadotropin release (short-loop mechanism), leading to aas-induced hypogonadism.
anabolic steroid
most of the hormones in the anterior pituitary are each part of an "axis" that is regulated by the hypothalamus. the hypothalamus secretes a number of releasing hormones, often according to a circadian rhythm, into blood vessels that supply the anterior pituitary; most of these are stimulatory (thyrotropin-releasing hormone, corticotropin-releasing hormone, gonadotropin-releasing hormone and growth hormone-releasing hormone), apart from dopamine, which suppresses prolactin production. in response to the releasing hormone rate, the anterior pituitary produces its hormones (tsh, acth, lh, fsh, gh) which in turn stimulate effector hormone glands in the body, while prolactin (prl) acts directly on the breast gland. once the effector glands produce sufficient hormones (thyroxine, cortisol, estradiol or testosterone and igf-1), both the hypothalamus and the pituitary cells sense their abundance and reduce their secretion of stimulating hormones. the hormones of the posterior pituitary are produced in the hypothalamus and are carried by nerve endings to the posterior lobe; their feedback system is therefore located in the hypothalamus, but damage to the nerve endings would still lead to a deficiency in hormone release.
hypopituitarism