failure of chromosome separation during meiosis is called polysomy.
failure of chromosome separation during meiosis is called polysomy.
failure of chromosome separation during meiosis is called?
polysomy
proper homologous chromosome separation in meiosis i is crucial for sister chromatid separation in meiosis ii. a failure to separate properly is known as nondisjunction. there are two main types of nondisjunction that occur: trisomy and monosomy. trisomy is caused by the presence of one additional chromosome in the zygote as compared to the normal number, and monosomy is characterized by the presence of one fewer chromosome in the zygote as compared to the normal number. if this uneven division occurs in meiosis i, then none of the daughter cells will have proper chromosomal distribution and severe effects can ensue, including down’s syndrome. unequal division can also occur during the second meiotic division. nondisjunction which occurs at this stage can result in normal daughter cells and deformed cells.
homologous chromosome
the special chromosome separation in meiosis, homologous chromosomes separation in meiosis i and chromatids separation in meiosis ii, requires special tension between homologous chromatids and non-homologous chromatids for distinguishing microtubule attachment and it relies on the programmed dna double strand break (dsb) and repair in prophase i. therefore meiotic recombination checkpoint can be a kind of dna damage response at specific time spot. on the other hand, the meiotic recombination checkpoint also makes sure that meiotic recombination does happen in every pair of homologs.









































section::::dsb-dependent pathway.
meiotic recombination checkpoint