the majority of drug absorption occurs in the gastrointestinal tract.
the majority of drug absorption occurs in the gastrointestinal tract.
where does the majority of drug absorption occur?
gastrointestinal tract
amongst the physico-chemical properties associated with drug absorption include ionization (pka), and solubility; permeability can be determined by pampa and caco-2. pampa is attractive as an early screen due to the low consumption of drug and the low cost compared to tests such as caco-2, gastrointestinal tract (git) and blood–brain barrier (bbb) with which there is a high correlation.
drug discovery
in recent years, bailey has slightly shifted the focus of his research to assessing the effect of fruit juices on other potentially important mechanisms of drug absorption. current research found that grapefruit and other juices (orange and apple) inhibited a specific intestinal drug uptake transporter (organic anion transporting polypeptide 1a2; oatp1a2) to diminish oral drug absorption discernibly in humans. the initial publication in 2002, which has been cited more than 100 times, supported a new model of intestinal drug absorption and novel mechanism of food-drug interactions. most recently, he showed that the major flavonoid in grapefruit, naringin, was an important clinically active inhibitor of intestinal oatp1a2. this appeared to be the first example of a single dietary constituent modulating drug transport in humans.
dave bailey (athlete)