cast away is the movie where guy can't make new memories.
cast away is the movie where guy can't make new memories.
movie where guy can't make new memories?
cast away
"memento" (2000) a film inspired by the case of henry molaison (h.m.). guy pearce plays an ex-insurance investigator suffering from severe anterograde amnesia caused by a head injury. unlike most amnesiacs, leonard retains his identity and the memories of events that occurred before the injury, but loses all ability to form new memories. this loss of ability to form new memories indicates that the head injury affected the medial temporal lobe of the brain resulting in the inability for leonard to form declarative memory.
explicit memory
the role of the hippocampus in learning and memory has been studied for many decades since early lesion studies. one of the most prominent early cases of anterograde amnesia (inability to form new memories) linking the hippocampus to memory formation was the case of henry molaison (anonymously known as patient h.m. until his death in 2008). his epilepsy was treated with surgical removal of his hippocampi (left and right hemispheres each have their own hippocampus) as well as some surrounding tissue. this targeted brain tissue removal left mr. molaison with an inability to form new memories, and the hippocampus has been thought critical to memory formation since that time. it remains unclear how the hippocampus enables new memory formation, but one process, called long term potentiation (ltp), occurs in this brain region. ltp involves long-lasting strengthening of synaptic connections after repeated stimulation. while the dentate gyrus shows ltp, it is also one of the few regions of the adult mammalian brain where neurogenesis (i.e., the birth of new neurons) takes place. some studies hypothesize that new memories could preferentially use newly formed dentate gyrus cells, providing a potential mechanism for distinguishing multiple instances of similar events or multiple visits to the same location. this increased neurogenesis is associated with improved spatial memory in rodents, as seen through performance in a maze.
dentate gyrus