lactic acid production would be the fate of the anaerobic glycolysis energy system.
lactic acid production would be the fate of the anaerobic glycolysis energy system.
lactic acid production would be the fate of which energy system?
anaerobic glycolysis
highly malignant tumors rely heavily on anaerobic glycolysis (metabolism of glucose to lactic acid even under ample tissue oxygen; warburg effect) and thus need to efflux lactic acid via mcts to the tumor micro-environment to maintain a robust glycolytic flux and to prevent the tumor from being "pickled to death". the mcts have been successfully targeted in pre-clinical studies using rnai and a small-molecule inhibitor alpha-cyano-4-hydroxycinnamic acid (acca; chc) to show that inhibiting lactic acid efflux is a very effective therapeutic strategy against highly glycolytic malignant tumors.
lactate shuttle hypothesis
lactic acid is chiral, consisting of two enantiomers. one is known as -(+)-lactic acid or ("s")-lactic acid and the other, its mirror image, is -(−)-lactic acid or ("r")-lactic acid. a mixture of the two in equal amounts is called -lactic acid, or racemic lactic acid. lactic acid is hygroscopic. -lactic acid is miscible with water and with ethanol above its melting point, which is around 17 or 18 °c. -lactic acid and -lactic acid have a higher melting point. lactic acid produced by fermentation of milk is often racemic, although certain species of bacteria produce solely (r)-lactic acid. on the other hand, lactic acid produced by anaerobic respiration in animal muscles has the s configuration and is sometimes called "sarcolactic" acid, from the greek "sarx" for flesh.
lactic acid