citric acid cycle takes place in matrix of the mitochondrion in mitochondria.
citric acid cycle takes place in matrix of the mitochondrion in mitochondria.
where does citric acid cycle take place in mitochondria?
matrix of the mitochondrion
in eukaryotic cells, the citric acid cycle occurs in the matrix of the mitochondrion. in prokaryotic cells, such as bacteria, which lack mitochondria, the citric acid cycle reaction sequence is performed in the cytosol with the proton gradient for atp production being across the cell's surface (plasma membrane) rather than the inner membrane of the mitochondrion. the overall yield of energy-containing compounds from the tca cycle is three nadh, one fadh, and one gtp.









































section::::discovery.
citric acid cycle
start from the state where glycogen is available and the citric acid cycle is severely down-regulated. once the cell has received a non-trivial load, and has expended the phosphocreatine reserve, a small quantity of atp will become discharged down to amp. amp will instantly up-regulate myophosphorylase, which will start liberating glucose from glycogen and make it available to the glycolytic pathway, producing pyruvate and recharging amp back to atp. due to the greater availability of pyruvate as a substrate, and pyruvate also contributing a citric acid cycle intermediate, α-ketoglutarate, while consuming glutamate, the citric acid cycle will also speed up. the combination of glycolysis and the citric acid cycle now balances atp production with atp demand and the pool of amp does not grow further. because all pyruvate is not burned down in the citric acid cycle — a consequence of the pyruvate's concentration regulating its burning at this moment — the excess is converted to lactate and passed into blood as lactic acid.
adenosine monophosphate deaminase deficiency type 1