the percentage of the inheritance of obesity that is accounted for by genetic factors is about 40 -- 70 %.
the percentage of the inheritance of obesity that is accounted for by genetic factors is about 40 -- 70 %.
the percentage of the inheritance of obesity that is accounted for by genetic factors is about?
40 -- 70 %
Na
Na
when mendel’s work on inheritance was rediscovered in 1900, scientists debated whether mendel’s laws could account for the continuous variation observed for many traits. one group known as the biometricians argued that continuous traits such as height were largely heritable, but could not be explained by the inheritance of single mendelian genetic factors. work by ronald fisher in 1918 mostly resolved debate by demonstrating that the variation in continuous traits could be accounted for if multiple such factors contributed additively to each trait. however, the number of genes involved in such traits remained undetermined; until recently, genetic loci were expected to have moderate effect sizes and each explain several percent of heritability. after the conclusion of the human genome project in 2001, it seemed that the sequencing and mapping of many individuals would soon allow for a complete understanding of traits’ genetic architectures. however, variants discovered through genome-wide association studies (gwass) accounted for only a small percentage of predicted heritability; for example, while height is estimated to be 80-90% heritable, early studies only identified variants accounting for 5% of this heritability. later research showed that most missing heritability could be accounted for by common variants missed by gwass because their effect sizes fell below significance thresholds; a smaller percentage is accounted for by rare variants with larger effect sizes, although in certain traits such as autism, rare variants play a more dominant role. while many genetic factors involved in complex traits have been identified, determining their specific contributions to phenotypes—specifically, the molecular mechanisms through which they act—remains a major challenge.
complex traits