white blood cells are made in bone marrow in your body.
white blood cells are made in bone marrow in your body.
where are white blood cells made in your body?
bone marrow
the cancellous part of bones contain bone marrow. bone marrow produces blood cells in a process called hematopoiesis. blood cells that are created in bone marrow include red blood cells, platelets and white blood cells. progenitor cells such as the hematopoietic stem cell divide in a process called mitosis to produce precursor cells. these include precursors which eventually give rise to white blood cells, and erythroblasts which give rise to red blood cells. unlike red and white blood cells, created by mitosis, platelets are shed from very large cells called megakaryocytes. this process of progressive differentiation occurs within the bone marrow. after the cells are matured, they enter the circulation. every day, over 2.5 billion red blood cells and platelets, and 50–100 billion granulocytes are produced in this way.
bone
psgl-1 is expressed on all white blood cells and plays an important role in the recruitment of white blood cells into inflamed tissue: white blood cells normally do not interact with the endothelium of blood vessels. however, inflammation causes the expression of cell adhesion molecules (cam) such as p-selectin on the surface of the blood vessel wall. white blood cells present in flowing blood can interact with cam. the first step in this interaction process is carried out by psgl-1 interacting with p-selectin and/or e-selectin on endothelial cells and adherent platelets. this interaction results in "rolling" of the white blood cell on the endothelial cell surface followed by stable adhesion and transmigration of the white blood cell into the inflamed tissue.
p-selectin glycoprotein ligand-1