carl wilhelm scheele devised the first test for detection of arsenic in 1775.
carl wilhelm scheele devised the first test for detection of arsenic in 1775.
who devised the first test for detection of arsenic in 1775?
carl wilhelm scheele
section::::precursor methods.









































the first breakthrough in the detection of arsenic poisoning was in 1775 when carl wilhelm scheele discovered a way to change arsenic trioxide to garlic-smelling arsine gas (ash), by treating it with nitric acid (hno) and combining it with zinc.









































in 1787, german physician johann metzger (1739-1805) discovered that if arsenic trioxide were heated in the presence of carbon, the arsenic would sublime. this is the reduction of aso by carbon:
marsh test
there are two routes by which inorganic arsenic compounds are methylated. the first route uses cyt19 arsenic methyltransferase to methylate arsenic (iii) to a mono-methylated arsenic (v) compound. this compound is then converted to a mono-methylated arsenic (iii) compound using glutathione s-transferase omega-1 (gsto1). the mono-methylated arsenic (v) compound can then be methylated again by cyt19 arsenic methyltransferase, which forms a dimethyl arsenic (v) compound, which can be converted to a dimethyl arsenic (iii) compound by glutathione s-transferase omega-1 (gtso1). the other route uses glutathione (gsh) to conjugate with arsenic (iii) to form an arsenic (gs) complex. this complex can form a monomethylated arsenic (iii) gs complex, using cyt19 arsenic methyltransferase, and this monomethylated gs complex is in equilibrium with the monomethylated arsenic (iii). cyt19 arsenic methyltransferase can methylate the complex one more time, and this forms a dimethylated arsenic gs complex, which is in equilibrium with a dimethyl arsenic (iii) complex. both of the mono-methylated and di-methylated arsenic compounds can readily be excreted in urine. however, the monomethylated compound was shown to be more reactive and more toxic than the inorganic arsenic compounds to human hepatocites (liver), keratinocytes in the skin, and bronchrial epithelial cells (lungs).
arsenic biochemistry