the number of base pairs in the diploid human genome is 46.
the number of base pairs in the diploid human genome is 46.
how many base pairs in diploid human genome?
46
Na
Na
there are 6 billion base pairs in the diploid human genome. statistical analysis reveals that a coverage of approximately ten times is required to get coverage of both alleles in 90% human genome from 25 base pair reads with shotgun sequencing. this means a total of 60 billion base pairs that must be sequenced. an applied biosystems solid, illumina or helicos sequencing machine can sequence 2 to 10 billion base pairs in each $8,000 to $18,000 run. the cost must also take into account personnel costs, data processing costs, legal, communications and other costs. one way to assess this is via commercial offerings. the first such whole diploid genome sequencing (6 billion bp, 3 billion from each parent) was from knome and their price dropped from $350,000 in 2008 to $99,000 in 2009. this inspects 3000-fold more bases of the genome than snp chip-based genotyping, identifying both novel and known sequence variants, some relevant to personal health or ancestry. in june 2009, illumina announced the launch of its own personal full genome sequencing service at a depth of 30x for $48,000 per genome. in 2010, they cut the price to $19,500.
personal genomics