the e in ebay stands for echo.
the e in ebay stands for echo.
what does the e in ebay stand for?
echo
Na
Na
the microvasculature of the subgranular zone, located in dentate gyrus of hippocampus, plays an important role in neurogenesis. as precursor cells develop in the subgranular zone, they form clusters. these clusters usually contain dozens of cells. the clusters are made up of endothelial cells and neuronal precursor cells that have the ability to differentiate into either neurons or glia cells. with time, these clusters eventually migrate towards microvessels in the subgranular zone. as the clusters get closer to the vessels, some of the precursor cells differentiate in glia cells and eventually the remaining precursor cells will differentiate into neurons. upon investigation of the close association between the vessels and clusters, it is apparent that the actual migration of the precursor cells to these vessels is not random. since endothelial cells forming the vessel wall do secrete brain-derived neurotrophic factor, it is plausible that the neuronal precursor cells migrate to those regions in order to grow, survive, and differentiate. also, since the clusters do contain endothelial cells, they might be attracted to the vascular endothelial growth factor that is released in the area of vessels to promote endothelial survival and angiogenesis. however, as noted previously, clustering along the capillaries in the subgranular zone does decrease when the brain is subject to radiation. the exact reasoning for this disruption of the close association between cluster and vessels remains unknown. it is possible that any signaling that would normally attract the clusters to the region, for example the bone-derived growth factor and the vascular endothelial growth factor, may be suppressed.
radiation-induced cognitive decline