astrocyte cell contributes to the blood-brain barrier in the central nervous system by providing biochemical support to endothelial cells.
astrocyte cell contributes to the blood-brain barrier in the central nervous system by providing biochemical support to endothelial cells.
what type of cell contributes to the blood-brain barrier in the central nervous system by providing biochemical support to endothelial cells?
astrocyte cell
the blood–brain barrier is composed of high-density cells restricting passage of substances from the bloodstream much more than do the endothelial cells in capillaries elsewhere in the body. astrocyte cell projections called astrocytic feet (also known as "glia limitans") surround the endothelial cells of the bbb, providing biochemical support to those cells. the bbb is distinct from the quite similar blood–cerebrospinal fluid barrier, which is a function of the choroidal cells of the choroid plexus, and from the blood–retinal barrier, which can be considered a part of the whole realm of such barriers.
blood–brain barrier
pericytes (previously known as rouget cells) are multi-functional mural cells of the microcirculation that wrap around the endothelial cells that line the capillaries and venules throughout the body. pericytes are embedded in basement membrane, where they communicate with endothelial cells of the body's smallest blood vessels by means of both direct physical contact and paracrine signaling. pericytes help to maintain homeostatic and hemostatic functions in the brain and also sustain the blood–brain barrier. these cells are also a key component of the "neurovascular unit", which includes endothelial cells, astrocytes, and neurons. pericytes regulate capillary blood flow, the clearance and phagocytosis of cellular debris, and the permeability of the blood–brain barrier. pericytes stabilize and monitor the maturation of endothelial cells by means of direct communication between the cell membrane as well as through paracrine signaling. a deficiency of pericytes in the central nervous system can cause the blood–brain barrier to break down.
pericyte