phenothiazines such as chlorpromazine were the first type of synthesized.
phenothiazines such as chlorpromazine were the first type of synthesized.
phenothiazines such as chlorpromazine were the first type of?
synthesized
there appears to be a dose-dependent risk for seizures with chlorpromazine treatment. tardive dyskinesia (involuntary, repetitive body movements) and akathisia (a feeling of inner restlessness and inability to stay still) are less commonly seen with chlorpromazine than they are with high potency typical antipsychotics such as haloperidol or trifluoperazine, and some evidence suggests that, with conservative dosing, the incidence of such effects for chlorpromazine may be comparable to that of newer agents such as risperidone or olanzapine.









































chlorpromazine may deposit in ocular tissues when taken in high dosages for long periods of time.









































section::::adverse effects.:contraindications.









































absolute contraindications include:









































bullet::::- circulatory
chlorpromazine
consuming food prior to taking chlorpromazine orally limits its absorption, likewise cotreatment with benztropine can also reduce chlorpromazine absorption. alcohol can also reduce chlorpromazine absorption. antacids slow chlorpromazine absorption. lithium and chronic treatment with barbiturates can increase chlorpromazine clearance significantly. tricyclic antidepressants (tcas) can decrease chlorpromazine clearance and hence increase chlorpromazine exposure. cotreatment with cyp1a2 inhibitors like ciprofloxacin, fluvoxamine or vemurafenib can reduce chlorpromazine clearance and hence increase exposure and potentially also adverse effects. chlorpromazine can also potentiate the cns depressant effects of drugs like barbiturates, benzodiazepines, opioids, lithium and anesthetics and hence increase the potential for adverse effects such as respiratory depression and sedation.
chlorpromazine