the fto gene has the potential influence of viruses.
the fto gene has the potential influence of viruses.
what potential influence does the fto gene have?
viruses
fto gene









































fat mass and obesity-associated protein also known as alpha-ketoglutarate-dependent dioxygenase fto is an enzyme that in humans is encoded by the "fto" gene located on chromosome 16. as one homolog in the alkb family proteins, it is the first mrna demethylase that has been identified. certain variants of the fto gene appear to be correlated with obesity in humans.









































section::::function.
fto gene
an example of an intronic vus controlling gene expression is the snp found in an intron of the fto gene. the fto gene encodes the fat mass and obesity-associated protein, and the snp (or vus) found in its intron was shown by genome-wide association studies to be associated with an increased risk for obesity and diabetes. the initial assumption was that this mutation was misregulating fto to cause the disease risk. however, it was later shown that the intronic variant was in fact regulating the distant irx3 gene and not the fto gene. that is just one example of how difficult it can be to determine the significance of a vus even when many research labs are focused on it, and it illustrates that clinicians cannot reliably interpret genetic results that have not been fully clarified by prior research.
variant of uncertain significance