thomas earl starzl said organ transplants are best left to the professionals.
thomas earl starzl said organ transplants are best left to the professionals.
who said organ transplants are best left to the professionals?
thomas earl starzl
Na
Na
the degree of histocompatibility required is dependent on individual factors, including the type of tissue or organ and the medical condition of the recipient. while whole organ transplants can be successful between unmatched individuals, increased histocompatibility lowers rates of rejection, result in longer lifespans, and overall lower associated hospital costs. the impact of hla matching differs even among whole organ transplants, with some studies reporting less importance in liver transplants as compared to heart, lung, and other organs. in comparison, hematopoietic stem cell transplants are often require higher degrees of matching due to the increased risk of graft-versus-host disease, in which the donor's immune system recognizes the recipient's mhc molecules as foreign and mounts an immune response. some transplanted tissue is not exposed to t cells that could detect foreign mhc molecules, such as corneas, and thus histocompatibility is not a factor in transplantation. individual factors such as age sometimes factors into matching protocol, as the immune response of older transplant patients towards mhc proteins is slower and therefore less compatibility is necessary for positive results. post-operative immunosuppressant therapy is often used to lessen the immune response and prevent tissue rejection by dampening the immune system's response to the foreign hla molecules, and can increase the likelihood of successful transplantation in non-identical transplants.
histocompatibility