formation of bony callus in fracture repair is followed by lamellar bone deposition.
formation of bony callus in fracture repair is followed by lamellar bone deposition.
formation of bony callus in fracture repair is followed by?
lamellar bone deposition
Na
Na
in osteoblast progenitor cells, osteoactivin works as a positive regulator of osteoblast differentiation during later stages of matrix maturation and mineralization that is mediated at least in part by bmp-2 in a smad1 dependent manner to promote osteoblast differentiation. in addition, using a rat fracture model, osteoactivin (oa) enhances the repairing process in bone fracture, demonstrated by its high expression during chondrogenesis (soft callus) and osteogenesis (hard callus) compared to the intact femurs that is why osteoactivin (oa) could be a novel therapeutic agent used to treat generalized osteoporosis or localized osteopenia during fracture repair by stimulating bone growth and regeneration. similarly, osteoactivin expression increases during osteoclast differentiation and it is functionally implicated in this process, possibly by promoting the fusion of osteoclast progenitor cells.
gpnmb