telomeres are located in the middle in a normal chromosome.
telomeres are located in the middle in a normal chromosome.
where are telomeres located in a normal chromosome?
in the middle
Na
Na
at rockefeller university her research focused on identifying proteins associated with telomeres and their role in protecting telomeres from processes of dna repair. in her first several years she dedicated a long amount of time and resources to identifying the major protein components of human telomeres. in 1995, she identified and purified the telomeric-repeat binding factor protein 1 (trf1). with the assistance of bas van steensel, de lange conducted various studies on proteins associated with telomeres. she found that trf1 is crucial in the regulation of the length of telomeres. in her research, she proposed that trf1 inhibits the action of telomerase. telomerase is an rna dependent dna polymerase that can elongate telomeres and is essential in the maintenance of telomeric dna. telomerase can counteract the shortening of telomeres, which occurs during the dna replication process. they also discovered the protein trf2 and found that it prevents the end-to-end fusing of telomeres, in addition to other functions. one of titia's major discoveries was the discovery of the t-loop structure of telomeres in her collaboration with jack griffith. this was shown through electron microscopy demonstrating that linear telomeric dna can be remodeled by trf2 into duplex loops (t loops). this architectural change allows for trf2 to sequester the ends of telomeres, which function to safeguard telomeres by covering overhanging single strands of dna. this mechanism protects against the improper activation of dna damage checkpoints by natural chromosome ends. previous research had observed that in addition to protecting the ends of chromosomes, telomeric complexes also allow cells to distinguish random dna breaks and natural chromosome ends.
titia de lange