cyclin - cdk is the molecule that initiates the halt of the cycle when damaged dna is detected in g1.
cyclin - cdk is the molecule that initiates the halt of the cycle when damaged dna is detected in g1.
which molecule initiates the halt of the cycle when damaged dna is detected in g1?
cyclin - cdk
Na
Na
throughout the cell cycle there are various checkpoints to ensure the cell is in good condition to progress to mitosis. the three main checkpoints are at g1/s, g2/m, and at the spindle assembly checkpoint regulating progression through anaphase. g1 and g2 checkpoints involve scanning for damaged dna. during s phase the cell is more vulnerable to dna damage than any other part of the cell cycle. g2 checkpoint checks for damaged dna and dna replication completeness. dna damage is an alteration in the chemical structure of dna, such as a break in a strand of dna, a base missing from the backbone of dna, or a chemically changed base such as 8-ohdg. dna damage can occur naturally or via environmental factors. the dna damage response (ddr) is a complex signal transduction pathway which recognizes when dna is damaged and initiates the cellular response to the damage.
dna damage (naturally occurring)