pepsin is found in the stomach in the digestive system.
pepsin is found in the stomach in the digestive system.
where is pepsin found in the digestive system?
in the stomach
pepsin is most active in acidic environments between 37 °c and 42 °c. accordingly, its primary site of synthesis and activity is in the stomach (ph 1.5 to 2). pepsin will digest up to 20% of ingested amide bonds by cleaving preferentially at the c-terminal side of aromatic amino acids such as phenylalanine, tryptophan, and tyrosine. pepsin exhibits preferential cleavage for hydrophobic, preferably aromatic, residues in p1 and p1' positions. increased susceptibility to hydrolysis occurs if there is a sulfur-containing amino acid close to the peptide bond, which has an aromatic amino acid. pepsin cleaves pheval, glnhis, gluala, alaleu, leutyr, tyrleu, glyphe, phe in the insulin b chain. pepsin exhibits maximal activity at ph 2.0 and is inactive at ph 6.5 and above, however pepsin is not fully denatured or irreversibly inactivated until ph 8.0. therefore, pepsin in solution of up to ph 8.0 can be reactivated upon re-acidification. the stability of pepsin at high ph has significant implications on disease attributed to laryngopharyngeal reflux. pepsin remains in the larynx following a gastric reflux event. at the mean ph of the laryngopharynx (ph = 6.8) pepsin would be inactive but could be reactivated upon subsequent acid reflux events resulting in damage to local tissues.
pepsin
bullet::::- --- cholecystolithiasis









































bullet::::- --- gallbladder neoplasms









































section::::--- digestive system diseases.:--- digestive system abnormalities.









































section::::--- digestive system diseases.:--- digestive system abnormalities.:--- choledochal cyst.









































bullet::::- --- caroli disease









































section::::--- digestive system diseases.:--- digestive system fistula.









































section::::--- digestive system diseases.:--- digestive system fistula.:--- esophageal fistula.









































bullet::::- --- tracheoesophageal fistula









































section::::--- digestive system diseases.:--- digestive system fistula.:--- intestinal fistula.









































bullet::::- --- rectal fistula









































bullet::::- --- rectovaginal fistula









































section::::--- digestive system diseases.:--- digestive system neoplasms.









































section::::--- digestive system diseases.:--- digestive system neoplasms.:--- biliary tract neoplasms.









































bullet::::- --- bile duct neoplasms









































bullet::::- --- common bile duct neoplasms









































bullet::::- --- gallbladder neoplasms
list of mesh codes (c06)