aluminum chloride functions as a catalyst in the friedel crafts acylation reaction.
aluminum chloride functions as a catalyst in the friedel crafts acylation reaction.
in the friedel crafts acylation reaction aluminum chloride functions as a?
catalyst
cathinone can be synthetically produced from propiophenone through a friedel-crafts acylation of propionic acid and benzene. the resulting propiophenone can be brominated, and the bromine can be substituted with ammonia to produce a racemic mixture of cathinone. a different synthetic strategy must be employed to produce enantiomerically pure (s)-cathinone. this synthetic route starts out with the n-acetylation of the optically active amino acid, s-alanine. then, phosphorus pentachloride (pcl) is used to chlorinate the carboxylic acid forming an acyl chloride. at the same time, a friedel-crafts acylation is preformed on benzene with aluminum chloride catalyst. finally, the acetyl protecting group is removed by heating with hydrochloric acid to form enantiomerically pure s-(-)-cathinone.
cathinone
the viability of the friedel–crafts acylation depends on the stability of the acyl chloride reagent. formyl chloride, for example, is too unstable to be isolated. thus, synthesis of benzaldehyde through the friedel–crafts pathway requires that formyl chloride be synthesized "in situ". this is accomplished by the gattermann-koch reaction, accomplished by treating benzene with carbon monoxide and hydrogen chloride under high pressure, catalyzed by a mixture of aluminium chloride and cuprous chloride.









































section::::friedel–crafts acylation.:reaction mechanism.
friedel–crafts reaction