the process of replication occurs at origins in the cell.
the process of replication occurs at origins in the cell.
where does the process of replication occur in the cell?
origins
in eukaryotic cells (cells that package their dna within a nucleus), chromosomes consist of very long linear double-stranded dna molecules. during the s-phase of each cell cycle (figure 1), all of the dna in a cell is duplicated in order to provide one copy to each of the daughter cells after the next cell division. the process of duplicating dna is called dna replication, and it takes place by first unwinding the duplex dna molecule, starting at many locations called dna replication origins, followed by an unzipping process that unwinds the dna as it is being copied. however, replication does not start at all the different origins at once. rather, there is a defined temporal order in which these origins fire. frequently a few adjacent origins open up to duplicate a segment of a chromosome, followed some time later by another group of origins opening up in an adjacent segment. replication does not necessarily start at exactly the same origin sites every time, but the segments appear to replicate in the same temporal sequence regardless of exactly where within each segment replication starts. figure 2 shows a cartoon of how this is generally envisioned to occur, while figure 3 shows an animation of when different segments replicate in one type of human cell.
replication timing
these nucleocapsids are surrounded by a single envelope that has projections made of glycoproteins protruding from its surface. these projections evenly cover the surface of the virion, and are about 5–10 nm long. they aid in attachment to the host receptor in replication.









































section::::replication.









































nairoviruses attach to the host receptor by their gn-gc glycoprotein dimer. the virus is then endocytosed into the host cell via a vesicle. the ribonucleocapsid segments are released into the cytoplasm, commencing transcription. transcription and replication occur within the cell, and the newly synthesized virions are released by budding.









































section::::transmission & distribution.
orthonairovirus