cocaethylene is produced as an active metabolite of cocaine.
cocaethylene is produced as an active metabolite of cocaine.
cocaethylene is produced as an active metabolite of?
cocaine
cocaethylene









































cocaethylene (ethylbenzoylecgonine) is the ethyl ester of benzoylecgonine. it is structurally similar to cocaine, which is the methyl ester of benzoylecgonine. cocaethylene is formed by the liver when cocaine and ethanol coexist in the blood.









































section::::metabolic production from cocaine.
cocaethylene
ticlopidine is a prodrug and is metabolized by at least five main pathways. there is one active metabolite that has been identified and shown to have antiplatelet activity. this active metabolite is formed by a cyp-dependent pathway. cyp2c19 and cyp2b6 are enzymes suggested to contribute to the metabolic transformation of ticlopidine to the thiolactone intermediate, 2-oxo-ticlopidine in the liver. the thiolactone intermediate is then converted to ticlopidine active metabolite via cyp oxidation where oxidation activation occurs. however the cyp enzymes that are involved in this pathway are unknown. in the formation of the active metabolite additional metabolites have been identified and they are dihydrothienopyridinium (m5) and thienodihydropyridinium metabolites (m6). these metabolites may be responsible for the toxic side effects of ticlopidine.
adenosine diphosphate receptor inhibitor