granulosa cells are the type of cells that are primarily responsible for the secretion of intrinsic factor.
granulosa cells are the type of cells that are primarily responsible for the secretion of intrinsic factor.
what type of cells are primarily responsible for the secretion of intrinsic factor?
granulosa cells
in pernicious anemia, which is usually an autoimmune disease, autoantibodies directed against intrinsic factor or parietal cells themselves lead to an intrinsic factor deficiency, malabsorption of vitamin b, and subsequent megaloblastic anemia. atrophic gastritis can also cause intrinsic factor deficiency and anemia through damage to the parietal cells of the stomach wall. pancreatic exocrine insufficiency can interfere with normal dissociation of vitamin b from its binding proteins in the small intestine, preventing its absorption via the intrinsic factor complex. other risk factors contributing to pernicious anemia are anything that damages or removes a portion of the stomach's parietal cells, including bariatric surgery, gastric tumors, gastric ulcers, and excessive consumption of alcohol.
intrinsic factor
the intrinsic factor is secreted by the stomach, and so is present in the gastric juice as well as in the gastric mucous membrane. the optimum ph for its action is approximately 7. its concentration does not correlate with the amount of hcl or pepsin in the gastric juice, e.g., intrinsic factor may be present even when pepsin is largely absent. the site of formation of the intrinsic factor varies in different species. in pigs it is obtained from the pylorus and beginning of the duodenum; in human beings it is present in the fundus and body of the stomach.
intrinsic factor