the gene linked to cystic fibrosis can be found in ( cftr ) protein.
the gene linked to cystic fibrosis can be found in ( cftr ) protein.
where can the gene linked to cystic fibrosis be found?
( cftr ) protein
intestinal organoids grown from rectal biopsies using culture protocols established by the clevers group have been used to model cystic fibrosis, and led to the first application of organoids for personalised treatment. cystic fibrosis is an inherited disease that is caused by gene mutations of the cystic fibrosis transmembrane conductance regulator gene that encodes an epithelial ion channel necessary for healthy epithelial surface fluids. studies by the laboratory of jeffrey beekman (wilhelmina children's hospital, university medical center utrecht, the netherlands) described in 2013 that stimulation of colorectal organoids with camp-raising agonists such as forskolin or cholera toxin induced rapid swelling of organoids in a fully cftr dependent manner. whereas organoids from non-cystic fibrosis subjects swell in response to forskolin as a consequence of fluid transport into the organoids' lumens, this is severely reduced or absent in organoids derived from people with cystic fibrosis. swelling could be restored by therapeutics that repair the cftr protein (cftr modulators), indicating that individual responses to cftr modulating therapy could be quantitated in a preclinical laboratory setting. schwank et al. also demonstrated that the intestinal cystic fibrosis organoid phenotype could be repaired by crispr-cas9 gene editing in 2013.
organoid
as well as general information about cystic fibrosis in canada and resources for teachers, parents, and health care professionals, cystic fibrosis canada publishes newsletters and reports covering such areas as research and training grants, clinical services and annual data on patients with cystic fibrosis.









































read the cystic fibrosis canada annual report 2014/2015 here









































section::::kin canada.









































since 1964, kin canada, a canadian service organisation, has supported cystic fibrosis canada, raising over $42 million in support of cystic fibrosis research and care.









































section::::see also.









































bullet::::- shinerama









































bullet::::- list of cystic fibrosis organizations









































bullet::::- cystic fibrosis foundation









































bullet::::- cystic fibrosis trust









































section::::external links.
cystic fibrosis canada