the function of the p53 protein is to regulate gene expression.
the function of the p53 protein is to regulate gene expression.
what is the function of the p53 protein?
regulate gene expression
tumor protein p53, also known as p53, cellular tumor antigen p53 (uniprot name), phosphoprotein p53, tumor suppressor p53, antigen ny-co-13, or transformation-related protein 53 (trp53), is any isoform of a protein encoded by homologous genes in various organisms, such as "tp53" (humans) and "trp53" (mice). this homolog (originally thought to be, and often spoken of as, a single protein) is crucial in multicellular organisms, where it prevents cancer formation, thus, functions as a tumor suppressor. as such, p53 has been described as "the guardian of the genome" because of its role in conserving stability by preventing genome mutation. hence "tp53" is classified as a tumor suppressor gene. ("italics" are used to denote the "tp53" gene name and distinguish it from the protein it encodes.)
p53
the p53 protein is continually produced and degraded in cells of healthy people, resulting in damped oscillation. the degradation of the p53 protein is associated with binding of mdm2. in a negative feedback loop, mdm2 itself is induced by the p53 protein. mutant p53 proteins often fail to induce mdm2, causing p53 to accumulate at very high levels. moreover, the mutant p53 protein itself can inhibit normal p53 protein levels. in some cases, single missense mutations in p53 have been shown to disrupt p53 stability and function.
p53