p53 works at the g1 / s transition stage of the cell cycle.
p53 works at the g1 / s transition stage of the cell cycle.
what stage of the cell cycle does p53 work?
g1 / s transition
Na
Na
studies of p53 dependent cell cycle arrest in response to dna damage identified p21 as the primary mediator of downstream cell cycle arrest. notably, el-deiry "et al." identified a protein p21 (waf1) which was present in cells expressing wild type p53 but not those with mutant p53, moreover constitutive expression of p21 led to cell cycle arrest in a number of cell types. dulcic "et al." also found that γ-irradiation of fibroblasts induced a p53 and p21 dependent cell cycle arrest, here p21 was found bound to inactive cyclin e/cdk2 complexes. working in mouse models, it was also shown that whilst mice lacking p21 were healthy, spontaneous tumours developed and g1 checkpoint control was compromised in cells derived from these mice. taken together, these studies thus defined p21 as the primary mediator of p53-dependent cell cycle arrest in response to dna damage.
p21