dna replication occurs during the mitotic phase of the cell cycle.
dna replication occurs during the mitotic phase of the cell cycle.
state during which phase of the cell cycle dna replication occurs?
mitotic
the cell cycle, or cell-division cycle, is the series of events that take place in a cell leading to duplication of its dna (dna replication) and division of cytoplasm and organelles to produce two daughter cells. in bacteria, which lack a cell nucleus, the cell cycle is divided into the b, c, and d periods. the b period extends from the end of cell division to the beginning of dna replication. dna replication occurs during the c period. the d period refers to the stage between the end of dna replication and the splitting of the bacterial cell into two daughter cells. in cells with a nucleus, as in eukaryotes, the cell cycle is also divided into two main stages: interphase and the mitotic (m) phase (including mitosis and cytokinesis). during interphase, the cell grows, accumulating nutrients needed for mitosis, and undergoes dna replication preparing it for cell division. during the mitotic phase, the replicated chromosomes and cytoplasm separate into two new daughter cells. to ensure the proper division of the cell, there are control mechanisms known as cell cycle checkpoints.
cell cycle
another major accomplishment was the discovery of the origin recognition complex (orc), a key protein made up of six subunits that binds to cellular origins of dna replication and coordinates the entire process of initiating a complete cycle of dna replication throughout the entire cell genome. soon after the discovery of orc, stillman’s group identified other initiation proteins that together form the pre-replication complex (pre-rc), which makes chromosomes competent for the subsequent initiation of dna replication during the s phase of the cell cycle. his group’s recent studies have revealed the intricate details of the mechanism of the initiation of dna replication and illuminated how this process is regulated throughout the cell cycle, including the mechanisms that prevent dna replication from occurring more than once during each cell cycle. these studies include elucidation of the structure of orc and its associated pre-rc proteins.
bruce william stillman