pepsin is found in the body in the small intestine.
pepsin is found in the body in the small intestine.
where do you find pepsin in the body?
small intestine
pepsin is most active in acidic environments between 37 °c and 42 °c. accordingly, its primary site of synthesis and activity is in the stomach (ph 1.5 to 2). pepsin will digest up to 20% of ingested amide bonds by cleaving preferentially at the c-terminal side of aromatic amino acids such as phenylalanine, tryptophan, and tyrosine. pepsin exhibits preferential cleavage for hydrophobic, preferably aromatic, residues in p1 and p1' positions. increased susceptibility to hydrolysis occurs if there is a sulfur-containing amino acid close to the peptide bond, which has an aromatic amino acid. pepsin cleaves pheval, glnhis, gluala, alaleu, leutyr, tyrleu, glyphe, phe in the insulin b chain. pepsin exhibits maximal activity at ph 2.0 and is inactive at ph 6.5 and above, however pepsin is not fully denatured or irreversibly inactivated until ph 8.0. therefore, pepsin in solution of up to ph 8.0 can be reactivated upon re-acidification. the stability of pepsin at high ph has significant implications on disease attributed to laryngopharyngeal reflux. pepsin remains in the larynx following a gastric reflux event. at the mean ph of the laryngopharynx (ph = 6.8) pepsin would be inactive but could be reactivated upon subsequent acid reflux events resulting in damage to local tissues.
pepsin
bredenbury received a post office in 1890 and was incorporated in 1913. the town was named for bredenbury court, located near bredenbury, herefordshire. the court was the manor home of william henry barneby, who traveled three times (in 1881, 1883, 1888) to western canada and wrote books about his experiences.









































section::::geography.









































bredenbury is located on the yellowhead highway (#16). it is 41 kilometres southeast of yorkton and 50 km west of the manitoba border. bredenbury is approximately 2.5 hours from regina and four hours from winnipeg. the surrounding land is mainly used for agriculture and ranching.









































section::::economy.
bredenbury, saskatchewan