sars-cov-2 viroporin regulates the nlrp3 inflammatory pathway
sars-cov-2 viroporin regulates the nlrp3 inflammatory pathway
we report that the sars-cov-2 viroporin encoded by orf3a activates the nlrp3 inflammasome, the most promiscuous of known inflammasomes.", "in a pared-down system, we investigate the influence of orf3a, an essential sars-cov-2 protein, on the inflammatory machinery and find that it activates nlrp3, the most prominent inflammasome by causing potassium loss across the cell membrane.")