use of convalescent serum reduces severity of covid-19 in nonhuman modelss
use of convalescent serum reduces severity of covid-19 in nonhuman modelss
one of the first proteins produced during viral infection, nsp1, binds to the host ribosome and blocks the mrna entry channel.", "in spite of the presence of nsp1 on the ribosome, viral translation proceeds however.", "thus, nsp1 acts as a ribosome gatekeeper, shutting down host translation or fostering sars-cov-2 translation depending on the presence of the sl1 5utr hairpin.", "we show that nsp1 remains bound on the ribosome during viral translation.")