restriction of sars-cov-2 replication by targeting programmed 1 ribosomal frameshifting in vitro
restriction of sars-cov-2 replication by targeting programmed 1 ribosomal frameshifting in vitro
importantly, frameshift inhibition by merafloxacin substantially impedes sars-cov-2 replication in vero e6 cells, thereby providing the proof of principle of targeting 1 prf as an effective antiviral strategy for sars-cov-2.", "through an unbiased, reporter-based high-throughput compound screen, we identified merafloxacin, a fluoroquinolone antibacterial, as a 1 prf inhibitor of sars-cov-2.", "frameshift inhibition by merafloxacin is robust to mutations within the pseudoknot region and is similarly effective on 1 prf of other beta coronaviruses."


































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