engineering human ace2 to optimize binding to the spike protein of sars coronavirus 2
engineering human ace2 to optimize binding to the spike protein of sars coronavirus 2
the selection of ace2 variants for high binding signal therefore reports not only on affinity, but also on presentation at the membrane of folded structure recognized by sars-cov-2 s. whether these mutations selectively stabilize a virus-recognized local structure in ace2 versus the global protein fold is unclear.