ad26 vaccine protects against sars-cov-2 severe clinical disease in hamsters
ad26 vaccine protects against sars-cov-2 severe clinical disease in hamsters
we assessed the clinical and virologic characteristics of high-dose sars-cov-2 infection in hamsters and evaluated the protective efficacy of an adenovirus serotype 26 (ad26) vector- based vaccine19 encoding a stabilized sars-cov-2 spike (s) in this stringent model.", "in this study, we demonstrated that a single immunization of an ad26 vector encoding a full-length prefusion stabilized s immunogen (s.pp) protected against severe clinical disease after high-dose sars-cov-2 challenge in hamsters.", 


































"in summary, our data demonstrate that a single immunization of ad26-s.pp provides robust protection against severe clinical disease after high-dose sars-cov-2 infection in hamsters.")