comparative genomics suggests limited variability and similar evolutionary patterns between major clades of sars-cov-2
comparative genomics suggests limited variability and similar evolutionary patterns between major clades of sars-cov-2
while levels of genomic variability between sars-cov-2 isolates are limited, to our knowledge, it is not clear whether the observed patterns of variability in viral super-clades reflect ongoing adaptation of sars-cov-2, or merely genetic drift and founder effects.", "although this study can not be conclusive, we believe that the evidence presented here is strongly consistent with the notion that the biased geographic distribution of sars- cov-2 isolates should not be associated with adaptive evolution of this novel pathogen.", 


































"here, we analyze more than 1100 complete, high quality sars-cov-2 genome sequences, and provide evidence for the absence of distinct evolutionary patterns/signatures in the genomes of the currently known major clades of sars-cov-2.", "we observe that while cross species adaptation of the virus is associated with hypervariability of specific protein coding regions (including the rdb domain of the spike protein), the more variable genomic regions between extant sars- cov-2 episomes correspond with the 3 and 5 utrs, suggesting that at present viral protein coding genes should not be subjected to different adaptive evolutionary pressures in different viral strains."


































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