an ultra-high affinity synthetic nanobody blocks sars-cov-2 infection by locking water into an inactive conformation
an ultra-high affinity synthetic nanobody blocks sars-cov-2 infection by locking water into an inactive conformation
affinity maturation and structure-guided design of multivalency yielded a trivalent nanobody, mnb6-tri, with femtomolar affinity for sars-cov-2 spike and picomolar neutralization of sars-cov-2 infection.", "here, we develop single-domain antibodies (nanobodies) that potently disrupt the interaction between the sars-cov-2 spike and ace2.")