both mutations in sars-cov-2 associate with severe and mild outcome
both mutations in sars-cov-2 associate with severe and mild outcome
here, we correlated protein-level mutations in the sars-cov-2 virus to clinical outcome.", "conclusions we demonstrate that mutations in the viral genes may have a direct correlation to clinical outcome.", "mutations correlated to mild outcome were located in the orf8, nsp6, orf3a, nsp4, and in the nucleocapsid phosphoprotein n. mutations associated with inferior outcome were located in the surface (s) glycoprotein, in the rna dependent rna polymerase, in the 3-to5 exonuclease, in orf3a, nsp2 and n. mutations leading to severe outcome with low prevalence were found in the surface (s) glycoprotein and in nsp7.", 


































"our results help to quickly identify sars-cov-2 infections harboring mutations related to severe outcome.")