stat2 signaling restricts viral dissemination but not severe pneumonia in sars-cov-2 infected hamsters
stat2 signaling restricts viral dissemination but not severe pneumonia in sars-cov-2 infected hamsters
we establish that in hamsters a dysregulated innate immune response is a driving force behind sars-cov-2 pathogenesis, in which in particular signal transducer and activator of transcription factor 2 (stat2)-dependent type i and iii ifn signaling plays a dual role: (i) restricting infection and dissemination on one hand but (ii) driving development of severe lung disease on the other.", "together, these data suggest that stat2 is critical for keeping virus replication and production of infectious progeny in the lungs down, as well as for restricting systemic sars-cov-2 spread and suppressing viral replication outside of the lung compartment.", 


































"by using unique ko hamster lines, we demonstrated that stat2 plays a critical role in mediating antiviral responses and restricting systemic dissemination of sars-cov-2 (see fig.")