sars-cov-2 inhibits platelet ace2 to enhance thrombosis in covid-19
sars-cov-2 inhibits platelet ace2 to enhance thrombosis in covid-19
sars-cov-2 and its spike protein directly bind platelet ace2 and enhance platelet activation in vitro.", "sars-cov-2 spike protein binds to ace2 and phosphorylates ace2, leading to mapk signaling activation (phosphorylation of erk, p-38, and jnk) and subsequent platelet activation, coagulation factors release, and inflammatory cytokines secretion.", "collectively, these data suggest that sars- cov-2-activated platelets may result in the pro-thrombotic state described in covid-19 patients.")