in silico mutagenesis of bat ace2 with s protein and translational efficiency explain sars-cov-2 infectivity in different species
in silico mutagenesis of bat ace2 with s protein and translational efficiency explain sars-cov-2 infectivity in different species
genomic variability across species, including humans, results in ace2 variants that destabilize its fold, modify ace2/sars- cov-2 recognition, or both.", "sars-cov-2 cell entry depends on ace2 and tmprss2 and is blocked by a clinically proven protease inhibitor.", "two significant factors conditioning infection are ace2-mediated sars-cov-2 cellular entry and viral proteome translation efficiency.", "we observed that humans are the species in which sars- cov-2 is both most efficiently translated as well as optimally interacting with ace2.", 


































"sars-cov-2 translational efficiency and ace2 expression across species.")