inhibition of pikfyve kinase prevents infection by zaire ebolavirus and sars-cov-2
inhibition of pikfyve kinase prevents infection by zaire ebolavirus and sars-cov-2
we describe here potent inhibitory effects on content release and infection by chimeric vesicular stomatitis virus (vsv) containing the envelope proteins of zaire ebolavirus (vsv-zebov) or severe acute respiratory syndrome coronavirus 2 (sars-cov-2) (vsv-sars-cov-2) elicited by apilimod and vacuolin-1, small- molecule inhibitors of the main endosomal phosphatidylinositol-3-phosphate/phosphatidylinositol 5-kinase, pikfyve.", "we have constructed chimeric forms of vesicular stomatitis virus (vsv) bearing the fusion proteins of zaire ebolavirus (zebov) or sars coronavirus 2 (sars-cov-2) and shown that two small-molecule inhibitors of an endosomal lipid kinase (pikfyve) inhibit viral infection by preventing release of the viral contents from endosomes."


































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