remdesivir and chloroquine effectively inhibit the recently emerged novel coronavirus in humans
remdesivir and chloroquine effectively inhibit the recently emerged novel coronavirus in humans
remdesivir has been recently recognized as a promising antiviral drug against a wide array of rna viruses (including sars/mers-cov5) infection in cultured cells, mice and nonhuman primate (nhp) models.", "remdesivir and chloroquine effectively inhibit the recently emerged novel coronavirus (2019-ncov) in vitro.", "s2) showed that remdesivir also inhibited virus infection efficiently in a human cell line (human liver cancer huh-7 cells), which is sensitive to 2019-ncov.2 chloroquine, a widely-used anti-malarial and autoimmune disease drug, has recently been reported as a potential broad-spectrum antiviral drug.8,9 chloroquine is known to block virus infection by increasing endosomal ph required for virus/cell fusion, as well as interfering with the glycosylation of cellular receptors of sars-cov.10 our time-of-addition assay demonstrated that chloroquine functioned at both entry, and at post-entry stages of the 2019-ncov infection in vero e6 cells (fig.", 


































"notably, two compounds remdesivir (ec50 = 0.77 μm; cc50 > 100 μm; si > 129.87) and chloroquine (ec50 = 1.13 μm; cc50 > 100 μm, si > 88.50) potently blocked virus infection at low-micromolar concentration and showed high si (fig.")