the d614g mutation in the sars-cov2 spike protein reduces infectivity in an ace2 receptor dependent manner
the d614g mutation in the sars-cov2 spike protein reduces infectivity in an ace2 receptor dependent manner
most prominent among these is the d614g amino acid substitution in the sars-cov2 spike protein, which mediates viral entry.", "these results are consistent with the possibility that the spike d614g mutant increases the infectivity of sars- cov2.", "here, we synthesized and expressed the wt and d614g variant sars-cov2 spike protein, and report that using a sars-cov2 spike protein pseudotyped lentiviral vector we observe that the d614g variant spike has >1/2 log10 increased infectivity in human cells expressing the human ace2 protein as the viral receptor.", 


































"the increased binding/fusion activity of the d614g spike protein was corroborated in a cell fusion assay using spike and ace2 proteins expressed in different cells.")