type i interferon limits viral dissemination-driven clinical heterogeneity in a native murine betacoronavirus model of covid-19
type i interferon limits viral dissemination-driven clinical heterogeneity in a native murine betacoronavirus model of covid-19
we find that extrapulmonary manifestations are due to viral metastasis and identify a critical role for type-i but not type-iii interferons in preventing systemic viral dissemination.", "we find that whereas high viral inoculums uniformly led to hypoxemic respiratory failure and death, lethal dose 50% (ld50) inoculums led to a recapitulation of most hallmark clinical features of covid-19, including lymphocytopenias, heart and liver damage, and autonomic dysfunction.")