the zinc channel antiviral protein restricts sars-cov-2
the zinc channel antiviral protein restricts sars-cov-2
strikingly, sars-cov-2 and its closest relatives from bats show the strongest cpg suppression among all known human and bat coronaviruses, respectively.", "thus, our results identify zap as an effector of the ifn response against sars-cov-2, although this pandemic pathogen may be preadapted to the low cpg environment in humans.", "type i, ii and iii ifns all strongly inhibited sars-cov-2 and further induced zap expression.", "here, we show that zinc finger antiviral protein (zap) that specifically targets cpg dinucleotides in viral rna sequences restricts sars-cov-2.", 


































"highlights sars-cov-2 and its closest bat relatives show strong cpg suppression ifn-β, -γ and -λ inhibit sars-cov-2 with high efficiency zap restricts sars-cov-2 and contributes to the antiviral effect of ifns ")