an ultra-potent synthetic nanobody neutralizes sars-cov-2 by locking light into an inactive conformation
an ultra-potent synthetic nanobody neutralizes sars-cov-2 by locking light into an inactive conformation
cryogenic electron microscopy (cryo-em) revealed that one exceptionally stable nanobody, nb6, binds spike in a fully inactive conformation with its receptor binding domains (rbds) locked into their inaccessible down-state, incapable of binding ace2.