the human brain vasculature shows a distinct expression pattern of sars-cov-2 entry factors
the human brain vasculature shows a distinct expression pattern of sars-cov-2 entry factors
our study serves as a publicly available single-cell atlas of sars-cov-2 related entry factors and interaction partners in human and mouse brain endothelial- and perivascular cells, which can be employed for future studies in clinical samples of covid-19 patients.", "we observed a distinct expression pattern of the cathepsins b (ctsb) and -l (ctsl) - which are able to substitute for the ace2 co-receptor tmprss2 - in the human vasculature with ctsb being mainly expressed in the brain vasculature and ctsl predominantly in the peripheral vasculature, and these observations were confirmed at the protein level in the human protein atlas and using immunofluorescence stainings.", 


































"this expression pattern of sars-cov-2 viral-entry associated proteases and sars-cov-2 interaction partners was also present in endothelial cells and microglia in the fetal brain, suggesting a developmentally established sars-cov-2 entry machinery in the human vasculature.", "at both the adult and fetal stages, we detected a distinct pattern of sars-cov-2 entry associated genes transcripts in brain vascular endothelial cells and microglia, providing a potential explanation for an inflammatory response in the brain endothelium upon sars-cov-2 infection."


































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