genome-wide crispr screen reveals host genes that regulate sars-cov-2 infection
genome-wide crispr screen reveals host genes that regulate sars-cov-2 infection
here we performed a genome-wide crispr screen with sars-cov-2 and identified known sars-cov-2 host factors including the receptor ace2 and protease cathepsin l. we additionally discovered novel pro-viral genes and pathways including the swi/snf chromatin remodeling complex and key components of the tgf-β signaling pathway.