intranasal fusion inhibitory lipopeptide requires direct contact sars-cov-2 transmission in ferrets
intranasal fusion inhibitory lipopeptide requires direct contact sars-cov-2 transmission in ferrets
one-sentence summary a dimeric form of a sars-cov-2-derived lipopeptide is a potent inhibitor of fusion and infection in vitro and transmission in vivo.", "we have designed a dimeric lipopeptide fusion inhibitor that blocks this critical first step of infection for emerging coronaviruses and document that it completely prevents sars-cov-2 infection in ferrets.", "daily intranasal administration to ferrets completely prevented sars-cov-2 direct-contact transmission during 24-hour co- housing with infected animals, under stringent conditions that resulted in infection of 100% of untreated animals."


































)