structure-guided multivalent nanobodies block sars-cov-2 infection and suppress mutational escape.
structure-guided multivalent nanobodies block sars-cov-2 infection and suppress mutational escape.
we further validated virus neutralization microscopically by quantifying the replication of an mneongreen expressing clone of sars-cov-2 on human caco2 cells in the presence of nanobodies over time (fig.", "affinity maturation and structure-guided design of multivalency yielded a trivalent nanobody, mnb6-tri, with femtomolar affinity for sars-cov-2 spike and picomolar neutralization of sars-cov-2 infection.", "the structure-based multivalent nanobodies we present have strong potential clinical applications owing to increased neutralizing activity and in-built protection from rapid emergence of escape mutants."


































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