sars-cov-2 orf3b is a potent interferon antagonist whose activity is further inhibited by a naturally occurring elongation variant
sars-cov-2 orf3b is a potent interferon antagonist whose activity is further inhibited by a naturally occurring elongation variant
interestingly, extension of sars-cov2 orf3b by removal of a premature stop codon enhances its ability to antagonise ifn-β induction.", "finally, sars-cov2 isolates from two severe covid-19 cases were shown to express the extended orf3b which shows increased ifn-β antagonism.", "a natural elongation variant of sars-cov-2 orf3b isolated from two patients showed a stronger suppression of interferon induction than wildtype sars-cov-2 orf3b.", "they find the truncated orf3b encoded by sars-cov-2 (22 aa) suppresses ifn-β induction more efficiently than the full-length sars-cov ortholog (~153 aa)."


































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