brd4-bound enhancers drive cell intrinsic sex differences in glioblastoma
brd4-bound enhancers drive cell intrinsic sex differences in glioblastoma
these observations led us to hypothesize that brd4-bound enhancers might underlie sex differences in stem cell function and tumorigenicity in gbm.", "we report that sex-biased brd4 activity drive sex differences in gbm and render male and female tumor cells differentially sensitive to bet inhibitors.", "these sex- biased gene expression patterns were also evident in human glioblastoma stem cells (gscs).", "in an established isogenic murine model of glioblastoma, we discovered correlated transcriptome-wide sex differences in gene expression, h3k27ac marks, large brd4-bound enhancer usage, and brd4 localization to myc and p53 genomic binding sites.", 


































"thus, for the first time, brd4 activity is revealed to drive a sex differences in stem cell and tumorigenic phenotype, resulting in diametrically opposite responses to bet inhibition in male and female gbm cells.")