the sars-cov-2 spike mutation d614g increases entry fitness across a range of ace2 levels , directly outcompetes the wild type , and is preferentially incorporated into trimers
the sars-cov-2 spike mutation d614g increases entry fitness across a range of ace2 levels , directly outcompetes the wild type , and is preferentially incorporated into trimers
we developed a cell line with inducible ace2 expression to confirm that d614g more efficiently enters cells with ace2 levels spanning the different primary cells targeted by sars-cov-2.", "mounting evidence suggests d614g enhances viral entry.", "using a new assay for crosslinking and directly extracting spike trimers from the pseudovirus surface, we found an increase in trimerization efficiency and viral incorporation of d614g protomers.")