scientists prove sars-cov-2 potential to infect human brain organoids
scientists prove sars-cov-2 potential to infect human brain organoids
to explore the direct involvement of sars-cov-2 in the cns in physiologically relevant models, the research team assessed sars-cov-2 infection in human neural progenitor cells (hnpcs), neurospheres and brain organoids derived from induced pluripotent stem cells (ipscs).", "\"overall, our study provides the first evidence of direct sars-cov-2 infection in human brain organoids, which contributes to our understanding of the pathogenesis of neurological complications in covid-19,\" said prof. huang jiandong from hku, who led the study.", 


































"extensive protein expression and infectious viral particles were detected in neurospheres and brain organoids infected with sars-cov-2, which suggested sars-cov-2 could productively infect the human brain.", "importantly, sars-cov-2 infection in 3d human brain organoids was localised to tuj1 (neuronal marker) - and nestin (npc marker)-positive cells, suggesting sars-cov-2 could directly target cortical neurons and npcs.", "the research team suggested that chronic and long-term consequences of sars- cov-2 infection of the cns should be closely monitored."


































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