the cellular immune response to covid-19 deciphered by single cell multi-omics across two uk centres.
the cellular immune response to covid-19 deciphered by single cell multi-omics across two uk centres.
together, these data detail the cellular processes present in peripheral blood during an acute immune response to covid-19, and serve as a template for multi-omic single cell data integration across multiple centers to rapidly build powerful resources to help combat diseases such as covid-19.", "full single cell transcriptomes coupled with quantification of 188 cell surface proteins, and t and b lymphocyte antigen receptor repertoires have provided several insights into covid-19: 1. a new non-classical monocyte state that sequesters platelets and replenishes the alveolar macrophage pool; 2. platelet activation accompanied by early priming towards megakaryopoiesis in immature haematopoietic stem/progenitor cells and expansion of megakaryocyte-primed progenitors; 3. increased clonally expanded cd8+ effector:effector memory t cells, and proliferating cd4+ and cd8+ t cells in patients with more severe disease; and 4. relative increase of iga plasmablasts in asymptomatic stages that switches to expansion of igg plasmablasts and plasma cells, accompanied with higher incidence of bcr sharing, as disease severity increases.", 


































"to characterise the systemic host immune response to sars-cov-2, we performed single-cell rna- sequencing coupled with analysis of cell surface proteins, providing molecular profiling of over 800,000 peripheral blood mononuclear cells from a cohort of 130 patients with covid-19.")