an engineered stable mini-cell to plug sars-cov2 spikes
an engineered stable mini-cell to plug sars-cov2 spikes
therefore, molecular entities able to interfere with binding of the sars-cov-2 spike protein to ace2 have a great potential to inhibit viral entry.", "starting from the available structural data on the interaction between sars-cov-2 spike protein and the host ace2 receptor, we here engineered a mini-protein with the aim of creating a soluble and stable spike interactor.", "by plugging the spike protein, our mini-protein constitutes a valid tool for the development of treatments against different types of coronavirus.", 


































"this mini-protein, which was recombinantly produced in high yields, possesses a stable α helical conformation and is able to interact with the rbd of glycosylated spike protein from sars-cov-2 with nanomolar affinity, as measured by microscale thermophoresis.", "like other coronaviruses, this novel virus relies on the surface spike glycoprotein to access the host cells, mainly through the interaction of its receptor binding domain (rbd) with the human angiotensin- converting enzyme 2 (ace2).")