high affinity nanobodies block sars-cov-2 spike receptor binding domain interaction with human angiotensin converting enzyme.
high affinity nanobodies block sars-cov-2 spike receptor binding domain interaction with human angiotensin converting enzyme.
( a ) illustration of the structure of sars-cov-2 spike protein, with receptor binding domain in contact with the human ace2 receptor on the surface of a lung epithelial cell.", "the sars-cov-2 virus gains entry to human cells via the angiotensin converting enzyme 2 (ace2) receptor by the interaction of the receptor binding domain (rbd) of the spike protein on the viral surface4,5,6,7,8.", "we have isolated nanobodies that bind to the sars-cov-2 spike protein receptor binding domain and block spike protein interaction with the angiotensin converting enzyme 2 (ace2) with 15 nm affinity.", 


































"we have isolated nanobodies that bind to the sars-cov-2 spike protein receptor binding domain and block spike protein interaction with the angiotensin converting enzyme 2 (ace2) with 1-5 nm affinity.")