researchers identify multiple sites that shut down sars-cov-2 polymerase reaction
researchers identify multiple sites that shut down sars-cov-2 polymerase reaction
they then demonstrated that sofosbuvir and four other nucleotide analogues (the active triphosphate forms of the hiv inhibitors alovudine, zidovudine, tenofovir alafenamide, and emtricitabine) also inhibited the sars-cov-2 polymerase with different levels of efficiency.", "while all 11 molecules tested displayed incorporation, six exhibited immediate termination of the polymerase reaction, two showed delayed termination, and three did not terminate the polymerase reaction.", "in an earlier set of experiments testing the properties of the polymerase of the coronavirus that causes sars, the researchers found that the triphosphate of sofosbuvir was able to terminate the virus polymerase reaction.", 


































"researchers at columbia engineering and the university of wisconsin-madison have identified a library of molecules that shut down the sars-cov-2 polymerase reaction, a key step that establishes the potential of these molecules as lead compounds to be further modified for the development of covid-19 therapeutics.")