sars-cov-2 activates lung epithelia cell proinflammatory signaling and leads to immune dysregulation in covid-19 patients by single-cell sequencing
sars-cov-2 activates lung epithelia cell proinflammatory signaling and leads to immune dysregulation in covid-19 patients by single-cell sequencing
results compared to healthy controls, the overall ace2 (receptor of sars- cov-2) expression was significantly higher in lung epithelial cells of covid-19 patients, in particular in ciliated cell, club cell and basal cell.", "moreover, sars-cov-2 infection altered the community interplay of lung epithelial cells and immune cells: the interaction between epithelial cells with macrophage, t and nk cell was stronger, but their interaction with neutrophils was lost in covid-19 patients compared to healthy controls.", 


































"conclusions sars-cov-2 infection activates pro-inflammatory signaling in lung epithelial cells expressing ace2 and causes dysregulation of immune response to release more pro-inflammatory cytokines.")