sars-cov-2 nsp1 binds the ribosomal mrna channel to promote translation
sars-cov-2 nsp1 binds the ribosomal mrna channel to promote translation
first, nsp1 acts as a strong inhibitor of translation, tightly binding ribosomes and reducing the pool of available ribosomes that can engage in translation.", "following viral infection and translation of viral genomic mrna (red), nsp1 acts as a translation inhibitor, reducing the pool of ribosomes that can engage in translation.", "these findings suggest that the extra density can be assigned to nsp1 that competes with mrna for ribosome binding to inhibit translation.", "3: sars-cov-2 nsp1 inhibits translation in hela cell lysates by binding to the 40s ribosomal subunit."


































)