sars-cov-2 infects brain choroid plexus and backs the blood-csf-barrier
sars-cov-2 infects brain choroid plexus and backs the blood-csf-barrier
we find that infected cells of the choroid plexus are an apolipoprotein and ace2 expressing subset of epithelial barrier cells.", "these findings suggest that neurological complications may result from effects on the choroid plexus, an important barrier that normally prevents entry of immune cells and cytokines into the cerebrospinal fluid (csf) and brain.", "we then challenge organoids with both sars-cov-2 spike protein pseudovirus and live virus to demonstrate high viral tropism for choroid plexus epithelial cells but not stromal cells, and little to no infection of neurons or glia.", 


































"here, we use brain organoids to examine sars-cov-2 neurotropism.", "finally, we show that infection with live sars-cov-2 leads to barrier breakdown of the choroid plexus.")