human organ chip-enabled pipeline to rapidly repurpose therapeutics during viral pandemics
human organ chip-enabled pipeline to rapidly repurpose therapeutics during viral pandemics
these data highlight the value of organ chip technology as a more stringent and physiologically relevant platform for drug repurposing, and suggest that amodiaquine should be considered for future clinical testing.", "with the emergence of the covid-19 pandemic, the airway chips were used to assess the inhibitory activities of approved drugs that showed inhibition in traditional cell culture assays only to find that most failed when tested in the organ chip platform.", "we provide a first demonstration of drug repurposing by using oseltamivir in influenza a virus-infected organ chip cultures and show that co-administration of the approved anticoagulant drug, nafamostat, can double oseltamivirs therapeutic time window.", 


































"here we show that human organ-on-a-chip (organ chip) microfluidic culture devices lined by highly differentiated human primary lung airway epithelium and endothelium can be used to model virus entry, replication, strain- dependent virulence, host cytokine production, and recruitment of circulating immune cells in response to infection by respiratory viruses with great pandemic potential.")