coronavirus nsp10/nsp16 methyltransferase cannot be targeted by nsp10-derived peptide in vitro and in vivo to reduce replication and pathogenesis
coronavirus nsp10/nsp16 methyltransferase cannot be targeted by nsp10-derived peptide in vitro and in vivo to reduce replication and pathogenesis
we demonstrate that a peptide derived from the nsp16-interacting domain of mhv nsp10 could inhibit 2'-o-mtase activity of different coronaviruses in vitro and viral replication of mhv and sars-cov replicon in cell culture, and it could strongly inhibit virus replication and pathogenesis in mhv-infected mice.