This 2022 U.S. Climate Ambition Report - the Eighth National Communication and Fifth Biennial Report of the United States to the UN Framework Convention on Climate Change - reports that the United States achieved its target of net economy-wide emissions reductions in the range of 17 percent below 2005 levels in 2020. It summarizes a series of policies and measures the United States has taken that will contribute to achieving its nationally determined contribution (NDC) target to reduce economy-wide net greenhouse gas (GHG) emissions 50-52 percent below 2005 levels in 2030, as well as to achieving net-zero emissions no later than 2050. These targets and actions align with the goal to limit global temperature rise to no more than 1.5 degrees Celsius above pre-industrial levels. The report also provides information regarding a range of actions undertaken by the United States to support adaptation and build resilience to the impacts of climate change in the United States, and to support climate action internationally. It reflects not only actions by the federal government, but those of a wide range of stakeholders engaged in taking action, building awareness, and advancing cutting-edge science and technology to enhance global climate efforts.