It stands out: Extension of vector-borne diseases that depends on changes in vegetation, availability of reservoirs or intermediate hosts associated with the direct effects of temperature and humidity on parasites and vectors.. Morbidity and mortality related to heat stress. High temperatures maintained for several days increase the mortality of the population. This is aggravated if the housing conditions are not adequate. Deaths occur mainly in the elderly population and are attributed to cardiovascular and respiratory disorders.  The rise in sea level and rainfall affect the populations that inhabit coastal areas or riverbanks. This fact is more important in the case of irregular settlements. In this case, greater overcrowding is considered, with an increase in respiratory or infectious diseases transmitted by water or by rodents, associated with a lack of sanitation, the presence of waste or the inadequate quality of drinking water. The country has sentinel posts for influenza and diarrhoea, and notification of hepatitis A, leptospirosis and hantavirus is mandatory. One of the factors that favor the development of harmful algal blooms in Uruguay is related to climatic aspects with temperatures above 20 C as in the summer season, light intensity and low water turbulence. Health is affected both by direct exposure in recreational bathing areas and by consumption of untreated contaminated water in the case of freshwater cyanotoxins, or ingestion of molluscs contaminated by saltwater red tide. Health effects caused by dermatitis, gastroenterocolitis, respiratory infections or liver disease, secondary to exposure to cyanotoxins, are not required to be registered; unlike food poisoning, where cases of ingestion of contaminated bivalve molluscs could be reported. In any case, there are no specific records discriminated. An underregistration is estimated. Stratospheric ozone depletion Strictly speaking, it is not part of &quot;climate change&quot;, which occurs in the troposphere, but several interactions between ozone depletion and greenhouse gas-induced warming have recently been described. The incidence of non-melanoma skin cancer has increased over time, constituting an important impact on health. In Uruguay, it has not been possible to determine a relationship between this type of cancer and the alteration of the ozone layer; but it is related to greater sun exposure for cultural or work-related reasons. The occurrence of extreme events