 US 50 Business is a four- to six-lane divided highway within and on either side of the central business district of Salisbury, where the highway intersects MD 349, US 13 Business, and MD 346.US 50 Business west of MD 349 is a mid-1950s upgrade of the original highway entering Salisbury from the northwest.The business route between MD 349 and MD 346 was a relocation of US 50 from Main Street built in the early 1960s.