 After passing American Legion Road, the business route enters the city limits of Salisbury and its name changes to Salisbury Parkway.At the intersection with MD 349 (Nanticoke Road) and Isabella Street, US 50 Business turns east, expands to six lanes, becomes a partially controlled access highway, and begins to parallel Main Street, the original alignment of US 50.After crossing the North Prong of the Wicomico River on a drawbridge, the business route intersects Division Street, the original alignment of US 13.