 East of MD 346, US 50 Business is part of the relocation of US 50 between Salisbury and Berlin completed in the mid-1960s.US 50 Business was designated when the US 50 portion of the Salisbury Bypass was completed in 2002.US 50 Business begins at a partial interchange with US 50, with ramps from US 50 east to US 50 Business east and US 50 Business west to US 50 west.