 Pfizer states that development on P57, the active ingredient of hoodia, was stopped due to the difficulty of synthesizing it.Jasjit Bindra, lead researcher for hoodia at Pfizer, states there were indications of unwanted effects on the liver caused by other components, which could not be easily removed from the supplement, adding, "Clearly, hoodia has a long way to go before it can earn approval from the Food and Drug Administration.Until safer formulations are developed, dieters should be wary of using it."