 Mark Lamarr was team A's captain for the first three series, after which Will Self took over.From the 2008 Anniversary Special, comedian Jack Dee became captain of team A.

Ulrika Jonsson has been team B's captain for the programme's entire run, with the exceptions of the pilot episode (in which Jonsson appeared as a guest) and a 2002 special, where Sara Cox assumed the captaincy due to illness, Jonsson did appear in a pre-recorded sketch used in the special.In series 4 and 5 Johnny Vegas was a permanent panelist on team B, and Angelos Epithemiou (played by comedian Dan Skinner), appeared in the same capacity in series 6 before replacing George Dawes (played by Matt Lucas) as scorekeeper thereafter.