 A year later, she published a paper describing the opposing effects of H1 and HMGB1 on the nucleosome.Histone H1 was shown to stabilize the structure by winding two turns of linker DNA around the octamer while HMGB1 destabilized the nucleosome by bending adjacent DNA.NMR spectroscopy was again used to show that H1 binds to the acidic tail of HMGB1 via its basic C-terminus, thus halting the HMGB1-DNA interaction.