 One commonly encountered neuropathologic histologic architectural pattern seen within certain tumors is the rosette.The purpose of this report is to review
the patterns of rosettes and pseudorosettes in the context of such tumors as medulloblastoma/primitive neuroectodermal tumor (PNET),
retinoblastoma, ependymoma, central neurocytoma and pineocytoma.More advanced methods of tissue examination such as histochemical and immunohistochemical profiling, genetic analysis, and electron microscopy have been developed, the microscopic review of H&E stained material remains a critical component of tumor diagnosis.