 But that has its limitations as agonist and antagonist do not necessarily bind in the same manner nor to the same site.So the importance of certain moiety may be overestimated and some moieties may be overlooked.An example for the synthesis of montelukast sodium

An example for the synthesis of zafirlukast

The receptor for cysteinyl leukotrienes LTC4, LTD4 and LTE4 are a viable target because of the importance of cysteinyl leukotrienes in mediating the responses in asthma.