 In the non-responders, the blood and tissue CoQ10 levels did increase with the supplementation but not to the extent that they increased in the responders.The average time to a discernible change in exercise tolerance and recovery time was 30 days in the group of patients who took 300 milligrams of Coenzyme Q10 daily and 60 days in the group of patients that took 100 milligrams of Coenzyme Q10 daily.The increased dosage of Coenzyme Q10 yielded greater effectiveness.