 If this point is not reached, phage extinction occurs, and immunosuppressed hosts recover their initial state.It has become clear that Acr proteins play an important role in allowing phage immune evasion, though it is still unclear how anti-CRISPR proteins synthesis can overcome the host’s CRISPR-Cas system, which can shatter the phage genome within minutes after the infection.Within all the Anti-CRISPR proteins that have been discovered so far, mechanisms have been described for only 15 of among them.