 Nevertheless, the presence of an "aca" gene just below anti-CRISPR genes has been observed.The first Acr protein families to be discovered were AcrF1, AcrF2, AcrF3, AcrF4 and AcrF5.These inhibitors are mainly found in "Pseudomonas" phages, which are capable of infecting "Pseudomonas aeruginosas" possessing a type I‑F CRISPR–Cas system.