 By 180 days, patients in both groups had experienced significant improvements in exercise tolerance and recovery time.Interestingly, despite the statistically significant increases, the chronic fatigue syndrome patients supplemented with Coenzyme Q10 could not reach the exercise tolerance levels of normal individuals, at least not within 180 days of supplementation.When the patients taking the Coenzyme Q10 were switched over to placebo, they reverted to the pre-Coenzyme Q10 treatment levels with 60 days (the 100-milligram group) and 90 days (the 300-milligam group).