 In 2013, Spiro moved to a New York criminal defense firm run by Benjamin Brafman, known for their high-profile clientele.Spiro has represented artists like Mick Jagger, Jay-Z, and Bobby Shmurda, as well as athletes such as Thabo Sefolosha, Pero Antić, Chris Copeland, Ben Gordon, DeMarcus Cousins, Matt Barnes, Charles Oakley, Aaron Hernandez, Julian Edelman, Jay Bromley, J. R. Smith, and Lorenzo Mauldin.He also led investigations and litigation involving Robert Durst, Philip Seymour Hoffman, and L'Wren Scott (Mick Jagger's girlfriend), and defended Thomas Gilbert Jr., who was accused of killing his father.