 During the French invasion of Russia, the regiment Vyazemsky commanded was a part of the 3rd brigade of the 15th Infantry Division, which was part of the Yevgeni Markov's corps of the 3rd Reserve Observatory Army.He fought in battles, including the battle of Kobrin and the battle of Gorodechno.On November 9, 1812, Vyazemsky was mortally wounded during the assault of Borisov.