 Wolfe is Anishnawbe (Ojibway) with family ties to Brunswick House First Nation, Nishnawbe Aski Nation.From 1999-2003 Wolfe was an Outpost Nurse in Sioux Lookout and Moose Factory.Wolfe with fellow Aboriginal midwifery students Cheryllee Bourgeois and Ellen Blais she started the Toronto Aboriginal Midwives Initiative in 2002, and held community meetings and consultations to determine what the Native community wanted and needed.