 As a senior, Spillane was again named second team All-MAC after compiling 88 tackles, 11 of which were for loss, 1.5 sacks and an interception, which he returned 35 yards for a touchdown.Spillane signed with the Tennessee Titans as an undrafted free agent on May 14, 2018.He was cut from the 53-man roster at the end of training camp and subsequently re-signed to the Titans practice squad on September 2.