 Layer three is the pyramidal layer and is made up larger pyramidal shaped neurons.These three layers are composed of pyramidal cells, cells that have a pyramidal shaped axon with long dendrites connecting to other cells in neighbouring columns.The second section of the neomammalian brain is the Internal Granular Layer, and is known as layer four by neuroscientists; this layer is responsible for receiving afferent signals from the hypothalamus and sends messages to the other layers.