 This research is important because choline metabolism has possible links to fish malodor syndrome, non-alcoholic fatty liver disease, atherosclerosis, and cardiovascular disease.Another key publication, A prominent glycyl radical enzyme in human gut microbiomes metabolizes trans-4-hydroxy-L-proline outlines an important research approach utilized by Balskus and her team; chemically-guided functional profiling.First an enzyme family of interest is identified (in this case, the GRE family) and the amino acid sequences of all the members are compared.