 The composition of the league's nine groups was announced on 30 August 2018.Gozzano, Pro Patria, Virtus Verona, Rimini, Imolese, Albissola, Vis Pesaro, Rieti, Potenza, Cavese and Vibonese all depart Serie D, having been promoted to Serie C.

Prato, Gavorrano and Santarcangelo joined the league, having been relegated from Serie C. 

Akragas was relegated from Serie C to Serie D, but the club did not register and was put into liquidation due to financial difficulties.Fondi was relegated from Serie C, but the club merged with F.C.