 He was nephew to Aulus Plautius, the man who led the Invasion of Britain in 43 AD, and it was through his good offices that Plautius Lateranus escaped the death penalty in AD 48, after his affair with the emperor Claudius' wife Messalina was discovered.Fortunately, Claudius held Aulus Plautius in high esteem.Though he escaped death, he was removed from his senatorial position, but was later granted re-admittance under Nero 

In AD 65, Plautius Lateranus, who was then consul designatus, was accused of conspiracy against the emperor in the Pisonian conspiracy.