 The OATPs most associated with these interactions are OATP1B1, OATP1B3 and OATP2B1, which are all present on the hepatocyte basolateral (sinusoidal) membrane.OATP1B1 and OATP1B3 are known to play an important role in hepatic drug disposition.These OATPs contribute towards first step of hepatic accumulation and can influence the disposition of drug via hepatic route.