 When a male reporter from "Despertar de Oaxaca" criticized Rodriguez’ use of ski masks in her series “La Mujer Enmascarada,” assuming it was an anachronic reference to "zapatismo", Rodriguez countered, “[T]he mask depends on your history and your personal experience.Maybe to you it represents zapatismo, but to an Esquimo it represents protection from the cold.” In 1999 Rodriguez told "Artsy", “What interests me about my art is the creation of a female language made up of symbols and images in the hopes of establishing a woman’s voice without any apologies.”

Another hallmark of Rodriguez’ art is her frequent use of cartoons.In her early work, underground-style cartoons allow Rodriguez to make satirical commentaries about women’s issues.