 Most viruses encoding virporins can replicate their genomes in the absence of the viroporin, even if they are impaired in propagation.Rotaviruses and picornaviruses, however, rely on their viroporins to facilitate the formation of viroplasm, or specialized intracellular compartments remodeled from the membrane of the endoplasmic reticulum in which genome replication occurs.Some viroporins have established functional effects exerted through protein-protein interactions.