 Following his selection, Span signed with the Twins on August 15, 2002 which caused him to miss all of the 2002 minor league season.He started his minor league career in 2003 at Elizabethton, the Twins rookie-league affiliate.In 2004, Span was promoted first to the Gulf Coast League Twins in Fort Myers, Florida and, after only appearing in 5 games, for the Quad Cities of the Low Single A Midwest League.