 The non-deuterostome invertebrate type 1 paracaspase closest related to PCASP3 can surprisingly be found in molluscs, which could indicate that there were 2 paralog type 1 paracaspases present in the first bilaterans (like in cnidarians), and that different bilateran lineages have kept one or the other paralog.The paracaspase in Dictyostelium seems to regulate osmotic stress tolerance by vacuolar expansion.Paracaspase in animals has mostly been studied in humans and mice (see