 Decades later, when the Hōjō clan sought to gain control of the Kantō, Kawagoe served as an important base of operations.Hōjō Ujitsuna seized it in 1537, and took Edo castle in 1524.For roughly two decades after that, the Uesugi launched a number of attempts to regain the region; in the 1545 battle of Kawagoe, the Hōjō garrison of Kawagoe defeated an attempted siege of Edo castle; this victory would lead to the end of Uesugi power in the region, and the near-total destruction of that clan.