 Comparatively, APEX methods have greater discriminating power than methods using this differential hybridization, as it is often impossible to obtain the optimal hybridization conditions for the thousands of probes on DNA microarrays (usually this is addressed by having highly redundant probes).However, the same density of probes cannot be achieved in APEX methods, which translates into lower output per run.Illumina Incorporated's Infinium assay is an example of a whole-genome genotyping pipeline that is based on primer extension method.