 Many investigators have found scanning for mutations using high resolution melting as a viable and practical way to study entire genes.DNA mismatch-binding proteins can distinguish single nucleotide mismatches and thus facilitate differential analysis of SNPs.For example, MutS protein from "Thermus aquaticus" binds different single nucleotide mismatches with different affinities and can be used in capillary electrophoresis to differentiate all six sets of mismatches (Drabovich & Krylov 2006).