 After playing sparingly against Oklahoma in the 2019 Peach Bowl due to a hamstring injury, Edwards-Helaire rushed 16 times for 110 yards and caught five passes for 54 yards in LSU's 42–25 win over Clemson in the 2020 National Championship Game.Following the end of the season Edwards-Helaire announced that he would forgo his senior season to enter the 2020 NFL Draft.Edwards-Helaire was selected by the Kansas City Chiefs in the first round with the 32nd overall pick in the 2020 NFL Draft.