 Following the restructuring at King's in 2009/2010, he decided to return to Greece, joining CPERI at CERTH in Thessaloniki.His research interests include genome structure, function and evolution, evolution of protein function, evolution of genetic information-processing systems, theory and applications of biological sequence comparison, data and knowledge representation for genomics, unsupervised machine learning in very large datasets, biologically-inspired hardware & software engineering (unpublished works), synthetic biology, exobiology, and science communication.Some of his best known contributions in the field of computational genomics include automated sequence annotation, the discovery of genomic context methods, the inference of metabolic pathways from genome sequences, the development of methods for large-scale clustering of sequence similarities, the definition of the Last Universal Common Ancestor (LUCA), and the quantification of horizontal gene transfer patterns across the "net of life".