 After his PhD, Ouzounis was a Human Frontiers Science Program (HFSP) Postdoctoral fellow at SRI International, Menlo Park, California.Ouzounis started his own laboratory, researching computational genomics, at the European Molecular Biology Laboratory, European Bioinformatics Institute (EMBL-EBI) in 1996.Ouzounis moved his laboratory in 2007 to King's College London (KCL), as a Professor, Chair and Director of the KCL Centre for Bioinformatics.