 The main east-west highway in the Eastern District is U.S. Route 33, which travels through the northern part of the district between Ripley and Spencer, in Roane County.The main north-south route is County Road 21, which runs from Ripley north to Parkersburg, and south to Charleston, passing through Fairplain, Kenna, and Goldtown before entering Kanawha County.North of Ripley, it is known locally as the Parkersburg Road, while south of Ripley it is the Charleston Road.