 Prorenin is a relatively large molecule, weighing approximately 46 KDa.Prorenin was discovered by Eugenie Lumbers in 1971.In addition to juxtaglomerular cells, prorenin is also synthesised by other organs, such as the adrenal glands, the ovaries, the testis and the pituitary gland, which is why it is found in the plasma of anephric individuals.