 The amino (N) terminal charged tails are the site of the post-translational modifications, such as the one seen in H3K36me3.H3K36me3 can bind chromodomain proteins such as MSL3 hMRG15 and scEaf3.It can bind PWWP proteins such as BRPF1 DNMT3A, HDGF2 and Tudor domains such as PHF19 and PHF1.