 Themes in S'eiltin's works include the impact of Western colonization, postmodernism, and statements of resistance and hope.One of S'eiltin's works, "Hit (House in Tlingit Language)", is a 2007 mixed-media installation, including video components, that includes a replica M16 rifle suspended in a 55-gallon glass tank of oil and water.The work demonstrates themes of colonialism and toxic masculinity.