 Isaac was the cantor of the synagogue in Nonnenstraat where his father, Hirschl (or Chaim) Pressburg, had been the rabbi.There had been rabbis in the family for at least a century.Henriette Pressburg married Hirschel (later Heinrich) Marx (1777–1838) on 22 November 1814 in the Nijmegen Synagogue, she receiving a twenty thousand guilder dowry.