 Despite the apparent efficacy of bicalutamide for priapism, a small clinical study found that bicalutamide monotherapy at a dosage of 50 mg/day had no effect on nocturnal erections in men with prostate cancer.The antigonadotropic antiandrogens , medroxyprogesterone acetate (MPA), and analogues have all been widely used to treat paraphilias (e.g., pedophilia) and hypersexuality in men.They suppress androgen levels to castrate or near-castrate levels and are highly effective in reducing sexual urges, arousal, and behaviors.