 On November 5, 1612, he was consecrated bishop in the Sistine Chapel by Scipione Caffarelli-Borghese, Archpriest of the Arcibasilica di San Giovanni in Laterano, with Fabio Biondi, Titular Latin Patriarch of Jerusalem, and Ulpiano Volpi, Archbishop of Chieti, serving as co-consecrators.On February 12, 1621, he was named Prefect of the Apostolic Datary.He was created Cardinal Priest in the consistory of April 19, 1621 during the papacy of Pope Gregory XV and received the red hat and title of San Matteo in Merulana on May 17, 1621.