 Although can shrink or stabilize prostate tumors and hence significantly slow the course of prostate cancer and prolong life, it is, unfortunately, not generally curative.While effective in slowing the progression of the disease initially, most advanced prostate cancer patients eventually become resistant to and prostate cancer growth starts to accelerate again, in part due to progressive mutations in the androgen receptor (AR) that result in the transformation of drugs like bicalutamide from antagonists to agonists.A few observations form the basis of the reasoning behind combined androgen blockade (CAB), in which castration and an are combined.