 However, bicalutamide does not increase sex hormone levels if combined with adequate doses of an antigonadotropin such as a analogue, estrogen, or progestogen, due to the negative feedback effects of these medications on sex-hormone production.Because bicalutamide does not lower androgen levels, it may be a particularly favorable antiandrogen for transgender women who wish to help preserve sex drive, sexual function, and/or fertility, as antiandrogens that strongly suppress levels of testosterone and its metabolites, such as and modulators, can greatly disrupt these functions.Although bicalutamide has the potential to increase testosterone levels, there is no effect of this testosterone due to the blockade of the by bicalutamide.