 In addition, they are used to treat sex offenders as a means of chemical castration for the purpose of reducing the likelihood of recidivism.Although they have not been studied in the treatment of paraphilias and hypersexuality, like flutamide and bicalutamide have been suggested as potential medications for these indications and may have superior tolerability and safety relative to antigonadotropic antiandrogens.As an example, because do not reduce estrogen levels, unlike antigonadotropic antiandrogens, they preserve bone mineral density (BMD) and have little or no risk of osteoporosis and associated bone fractures.