 Many vaginal anomalies are not detected at birth because the external genitalia can appear to be normal.Some congenital syndromes present with vaginal anomalies in association with other serious conditions.These include Fraser syndrome, WNT4 deficiency, and Bardet-Biedl syndrome, Isolated incidents of vaginal anomalies can occur with no apparent cause and in other instances these anomalies are part of a syndrome or cluster of other abnormalities.