 It involves the presence of basophilic inclusions in the gonads and the presence of virus particles that have been classified as papovaviruses/ papillomaviruses-polyomaviruses.They may be propagated during spawning or by vertical transmission and have an icosahedral shape.Ovocytes appear to be among the infected cells and their nuclei are hypertrophic, and the host does not noticeably respond with an immune response.