 The combination of bicalutamide with an estrogen such as ethinylestradiol sulfonate has been used as a form of and as an alternative to the combination of bicalutamide with surgical or medical castration.Androgens like testosterone and play a critical role in the pathogenesis of a number of dermatological conditions including acne, seborrhea, hirsutism (excessive facial/body hair growth in women), and pattern hair loss (androgenic alopecia).In demonstration of this, women with complete androgen insensitivity syndrome (CAIS) do not produce sebum or develop acne and have little to no body, pubic, or axillary hair.