 However, due to unopposed estrogen signaling, a substantial incidence of gynecomastia is associated with .In addition to potential monotherapy use, have been advocated for temporarily suppressing sex drive during the start of agonist treatment via prevention of the increased androgen signaling associated with the initial testosterone flare.Though treatment of paraphilias and hypersexuality with selective antagonists is a seemingly sound strategy, this may not be true in practice.