 She was the second of the five children of Isaac Heymans Pressburg (1747–1832) and Nanette Salomons Cohen (1754–1833).The Pressburgs were a prosperous family, with Isaac working as a textile merchant.They were prominent members of Nijmegen's growing Jewish community, living first in Nonnenstraat then, when Henriette was 19, in Grotestraat.