 Mean total levels of estradiol in the boys were 3.8 pg/mL at baseline and were relatively unchanged at 6 and 12 months (2.5 pg/mL and 3.5 pg/mL, respectively).The dosage of bicalutamide was initiated at 12.5 mg/day and was then increased, with adjustment as necessary to maintain trough circulating ("R")-bicalutamide concentrations within a target range of 5 to 15 μg/mL.This range is similar to ("R")-bicalutamide levels achieved with approximately 30 to 100 mg/day bicalutamide in adult men with prostate cancer.