 In addition, one case of mildly elevated liver enzymes (1 of 14; 7%), possibly related to bicalutamide, was observed but resolved spontaneously without discontinuation of therapy.Additional research is necessary to more clearly determine the true effectiveness and safety of bicalutamide and anastrozole in the treatment of .No long-term results for the study have been published as of yet, but a 5-year follow-up of two of the boys in the study was published and reported continued effectiveness.