 US 301 has an at-grade railroad crossing with the Chestertown Branch of the Northern Line of the Maryland and Delaware Railroad west of the junction of the two Northern Line branches at Massey.North of the railroad, the U.S. highway has a superstreet intersection with MD 313 (Galena Road) south of Galena.US 301 has a diamond interchange with MD 290 (Galena Sassafras Road) before crossing the Sassafras River into Cecil County west of Sassafras.