 After exiting Waverly, it briefly reenters Pee Pee Township before crossing the Scioto River and entering Seal Township.In the community of Greggs Hill, SR 220 passes under two railroad overpasses and makes an S-curve before continuing south.For the remainder of the route, the route heads nearly due south east of Piketon and through Zahns Corner before ending at an intersection with the four-lane divided SR 32 and SR 124 (also called the James A. Rhodes Appalachian Highway).