 The U.S. Highway has a superstreet intersection with MD 544 (McGinnes Road) just west of that highway's eastern end at MD 313 and just south of Unicorn Branch.US 301 crosses the Chester River into Kent County west of Millington.The highway continues through an indirect interchange with MD 291 (River Road); access to MD 291 is via side ramps with two unsigned portions of MD 701, which parallels the northbound and southbound sides of US 301 as Howard Johnson Road and Edge Road, respectively.