 When SR 124 was moved on a new alignment south of Piketon between 1953 and 1955, SR 220 was routed along a former portion of SR 124 called Zahns Corner Road.In the mid 1990s when the Appalachian Highway was dualized across the state, SR 220's eastern terminus was moved further east along another old segment of SR 124 bringing the total mileage to over .By 2013, SR 220's eastern terminus was moved to a location near its original southern terminus from 1923 when a portion of Schuster Road (CR 81) was taken over by the state between the Appalachian Highway and the intersection of SR 220 and Zahns Corner Road.