 On October 7, 1926, both the Lancaster and Lititz Turnpike and the Lexington Turnpike were sold to the state and Lancaster County at $70,000 and $4,000, respectively.When routes were first legislated in Pennsylvania in 1911, the current route of PA 501 was not given a route number.PA 501 was designated in 1928 to run from PA 72 (Prince Street) in Lancaster north to PA 5 (now US 322) in Brickerville, running along a paved road.