 In such a situation, mitoKATP channels open and close to regulate both internal Ca2+ concentration and the degree of membrane swelling.This helps restore proper membrane potential, allowing further H+ outflow, which continues to provide the proton gradient necessary for mitochondrial ATP synthesis.Without aid from the potassium channels, the depletion of high energy phosphate would outpace the rate at which ATP could be created against an unfavorable electrochemical gradient.