 Nucleotide excision repair is also needed for repair of oxidative DNA damage due to hydrogen peroxide (), and DGCR8 depleted cells are sensitive to .In "Drosophila", flies with mutations that augment JNK signaling accumulate less oxidative damage and live dramatically longer than wild-type flies.In the tiny roundworm "Caenorhabditis elegans", loss-of-function mutants of JNK-1 have a decreased life span, while amplified expression of wild-type JNK-1 extends life span by 40%.