 Three N-terminal YXXP motifs may serve as binding sites for talin or v-Crk SH2.Paxillin is a signal transduction adaptor protein discovered in 1990 in the laboratory of Keith Burridge The C-terminal region of paxillin contains four LIM domains that target paxillin to focal adhesions.It is presumed through a direct association with the cytoplasmic tail of beta-integrin.