 The U.S. Highway curves north and intersects the Pope's Creek Subdivision rail line and crosses the Western Branch of the Patuxent River south of its cloverleaf interchange with MD 4 (Stephanie Roper Highway).US 301 meets the eastern end of MD 725 (Marlboro Pike) east of Upper Marlboro.The highway continues north and gains a wide median at the southern edge of the city of Bowie.