 US 301 and MD 5 diverge at a partial interchange in Brandywine, from which MD 5 continues north along Branch Avenue toward Washington and US 301 drops to four lanes.US 301 curves northeast and intersects Brandywine Road, which heads east through the center of Brandywine as MD 381.Brandywine Road to the west provides access from southbound US 301 to northbound MD 5 and from southbound MD 5 to northbound US 301.