 The route heads north from Lancaster and runs through suburban and rural areas in northern Lancaster County, passing through Lititz and crossing US 322 in Brickerville.PA 501 continues into Lebanon County and heads into the Lebanon Valley, where it passes through Schaefferstown and intersects US 422 in Myerstown.The route passes through western Berks County, where it has an interchange with Interstate 78 (I-78)/US 22 near the community of Bethel.