 After winning the Argentinian league with San Lorenzo, Ledesma was signed by the Greek champions Olympiacos, for roughly €1,800,000 giving him an opportunity to play in the Greek league and the UEFA Champions League.After one year with Olympiacos, he was loaned back to San Lorenzo for one season in August 2008.On 13 July 2010, Ledesma returned to Colón on a free transfer.