 Abnormal activity (higher or lower than physiological) of P38 has been implicated in pathological events in several tissues, that include neuronal,
bone, lung, cardiac and skeletal muscle, red blood cells, and fetal tissues.The protein product of Proto-oncogene RAS can increase activity of p38, and thereby cause excessively high activity of transcription factor NF-κB.This transcription factor is normally regulated from intracellular pathways that integrate signals from the surrounding tissue and the immune system.