 Based in Manhattan, New York, in the 1970s Mosbacher was married to Robert Muir, and after their divorce in 1977, for a time she was married to George Barrie, the CEO of Faberge and Brut Productions.On March 1, 1985, she married Robert Mosbacher, moving to Houston.In 1989 President, George H. W. Bush appointed Robert Mosbacher to the position of United States Secretary of Commerce.