 The route headed east from PA 72 on Liberty Street before it turned north and followed Lititz Avenue out of Lancaster, continuing along its current alignment to Brickerville.PA 243 was designated in 1928 to run from US 22/PA 3 (now US 422) in Myerstown north to PA 43 (now Old Route 22) in Bethel, following an unpaved road.PA 243 was paved by 1930.