 He turned professional in 1995 with the French Le Groupement team and moved on to the Polti team in 1996, where he scored eleventh place at Paris–Roubaix and third place at the French championship.Guesdon had his breakthrough year in 1997.Having signed with the new Française des Jeux team, he scored an early victory for the team in the prestigious spring monument Paris–Roubaix.