 PA 501 crosses Blue Mountain into Schuylkill County and continues to its northern terminus.The portion of the road in northern Lancaster County was originally established as two private turnpikes in the 19th century, becoming a public road in 1926.PA 501 was designated in 1928 to run from PA 72 in Lancaster north to PA 5 (now US 322) in Brickerville while PA 243 was designated onto the road running between US 22/PA 3 (now US 422) in Myerstown and PA 43 in Bethel.