 Mutations in "PXN" as well as abnormal expression of paxillin protein has been implicated in the progression of various cancers.Human paxillin is 64.5 kDa in molecular weight and 591 amino acids in length.The C-terminal region of paxillin is composed of four tandem double zinc finger LIM domains that are cysteine/histidine-rich with conserved repeats; these serve as binding sites for the protein tyrosine phosphatase-PEST, tubulin and serves as the targeting motif for focal adhesions.