 At this point, the route turns west and remains along Lancaster Avenue, curving to the north into business areas as a three-lane road with a center left-turn lane and reaching an interchange with I-78/US 22.Past this interchange, PA 501 narrows to two lanes and heads through farmland, turning northwest as it passes to the east of a warehouse.The road continues through a mix of farms and trees with some homes, heading to the north.