 While she generally takes a Republican standpoint in relation to political issues, she has at times expressed frustration with Republican candidates and politicians, for example over incidents such as Congress stalling the vote on aid for Hurricane Sandy in 2012.For several decades, Mosbacher has been involved with a number of non-profit organizations.In 1995 she founded the Children’s Advocacy Center of Manhattan (CAC), currently known as the New York Center for Children, which aims to assist abused children and their families.