 The structural reorganization of paxillin in cardiomyocytes has also been detected in mouse models of dilated cardiomyopathy.In a mouse model of tropomodulin overexpression, paxillin distribution was revamped coordinate with increased phosphorylation and cleavage of paxillin.Similarly, paxillin was shown to have altered localization in cardiomyocytes from transgenic mice expressing a constitutively-active rac1.