 The road between Brickerville and Myerstown and Bethel and Pine Grove was an unnumbered, unpaved road.In the 1930s, PA 501 was extended north from US 322 in Brickerville to US 422 and the southern terminus of PA 243 in Myerstown along a paved road.Also, US 222 was designated concurrent with the route between PA 72 at Prince Street and Oregon Pike.