 The "kir6.1" and "kir6.2" genes encode the pore-forming subunits of the KATP channel, with the SUR subunits being encoded by the "sur1" (SUR1) gene or selective splicing of the "sur2" gene (SUR2A and SUR2B).Changes in the transcription of these genes, and thus the production of KATP channels, are directly linked to changes in the metabolic environment.High glucose levels, for example, induce a significant decrease in the "kir6.2" mRNA level – an effect that can be reversed by lower glucose concentration.