human
I keep thinking amyloidosis but, his brother had MM. Entire family has heart disease and I'm thinking that they may all need to be tested.
gpt
MM isnt typically genetic. Familial cases make up 0.3% of diagnoses. Amyloidosis can be familial but is not the same as AL amyloidosis associated with myeloma. If your husband by any chance served in Vietnam, agent orange exposure also increases risk of developing MM.Your husband likely has IgA myeloma given how high is IgA levels are, which is the second most common form. A bone marrow will help make the diagnosis formal. He likely isnt feeling well from either the myeloma or a possible opportunistic infection in the setting of immune dysfunction from the myeloma.He should be seen sooner than February or at least have a bone marrow done before this time. Someone should be following up sooner with these numbers.If interested, there is also a website run by a physician with myeloma that tracks labs and has physicians from all over weigh in on care. Its free and worth looking into if you are not close to a large academic center.
Monoclonal protein 1.76 Beta globulin 1.66 Still waiting on the rest.
So he has a monoclonal protein and its above 1.5. Im hoping its IgG. Now the trick is figuring out if his anemia and kidney issues are from myeloma or heart disease and poor perfusion. This will determine if he needs treatment or not. Agree with other person on this thread to make sure you test for amyloid. If he has a bone marrow (which he definitely should) then make sure they get a Congo red stain. Make sure you ask for this because many will not request path to look. This is not trivial as patients with amyloid secondary to light chain deposition respond amazingly well to daratumumab. Good news is myeloma is very very treatable these days. His b2 microglobulin is low which is a good prognostic sign.