 
 <prompt> How serious fit shift work be wen we dey talk about how e fit affect human beings? Given di last question, write one context wey contain di answer. E fit be 1 - 20 sentences. Context: <response>: Shift-work or chronic jet-lag get serious effect for body circadian and metabolic events. Animals wey dem force make dem chop during their resting time dey show say dem dey get big body and the way clock and metabolic genes dey work dey change. For humans, shift-work wey dey make person chop at irregular times dey cause wahala for insulin sensitivity and body size. Shift-work also dey bring more risk for metabolic wahala like cardio-metabolic syndrome, hypertension, and inflammation. 