 
 <prompt> text: ```Use di article answer di questions.

Di way bacteria dey resist antibiotics na common tin wey dey happen. Di resistance wey dey happen often show say evolutionary processes dey occur during antibiotic therapy. Di antibiotic treatment fit select for bacterial strains wey get enhanced capacity to survive high doses of antibiotics either physiologically or genetically. Under certain conditions, e fit lead to preferential growth of resistant bacteria, while di growth of susceptible bacteria dey inhibited by di drug. For example, for 1943, di Luria-Delbrück experiment show say antibacterial selection dey happen for strains wey don acquire antibacterial-resistance genes before. Antibiotics like penicillin and erythromycin wey dey effective against many bacterial species and strains before don dey less effective now, because many bacterial strains don dey resistant.

For antimicrobial therapy to work well with antibacterial compounds, e dey depend on different factors. Dis factors include host defense mechanisms, di location of infection, and di pharmacokinetic and pharmacodynamic properties of di antibacterial. Di ability of antibacterials to kill bacteria fit depend on di growth phase of di bacteria, and e often require ongoing metabolic activity and division of bacterial cells. Dis findings dey based on laboratory studies, and for clinical settings, e don show say e fit eliminate bacterial infection. Since di activity of antibacterials dey often depend on di concentration, in vitro characterization of antibacterial activity usually involve determination of di minimum inhibitory concentration and minimum bactericidal concentration of di antibacterial. To predict clinical outcome, di antimicrobial activity of an antibacterial usually dey combined with its pharmacokinetic profile, and several pharmacological parameters dey used as markers of drug efficacy.

1. Wetin dem show for 1943?
2. By wetin?
3. Wetin don dey less effective?
4. Wetin kind?
5. Wetin dey depend on different factors?
6. Wetin e include?
7. Wetin fit depend on di growth phase?
8. Wetin e require?
9. Any other thing?
10. Wetin fit eliminate infections?

Numbered answers:``` <response>: ```1. antibacterial selection for strains wey don already get antibacterial-resistance genes
2. di Luria–Delbrück experiment.
3. . Antibiotics
4. penicillin and erythromycin
5. Di successful result of antimicrobial therapy
6. host defense mechanisms, di place wey infection dey happen, and di pharmacokinetic and pharmacodynamic properties of di antibacterial.
7. A bactericidal activity of antibacterials
8. ongoing metabolic activity
9. division of bacterial cells.
10. antibacterials``` 