 
 <prompt> Wetin fit happun wen antibiotic target no dey inside bacterial genome? If antibiotic target dey absent from bacterial genome, e fit cause resistance to the antibiotic wey dey target am. Dis fit make di antibiotic no fit kill di bacteria wey dey cause infection, and e fit make di infection worse. E fit also make di bacteria evolve and develop new ways to survive without di antibiotic. Dis fit lead to serious health problems and make di antibiotic less effective for treating infections. <response>: Several molecular mechanisms of antibacterial resistance dey exist. Intrinsic antibacterial resistance fit dey part of the genetic makeup of bacterial strains. For example, an antibiotic target fit dey absent from the bacterial genome. Acquired resistance fit result from a mutation for the bacterial chromosome or the acquisition of extra-chromosomal DNA. Antibacterial-producing bacteria don evolve resistance mechanisms wey don show say dem dey similar to, and fit don dey transferred to, antibacterial-resistant strains. The spread of antibacterial resistance dey often happen through vertical transmission of mutations during growth and by genetic recombination of DNA by horizontal genetic exchange. For instance, antibacterial resistance genes fit dey exchanged between different bacterial strains or species via plasmids wey carry these resistance genes. Plasmids wey carry several different resistance genes fit confer resistance to multiple antibacterials. Cross-resistance to several antibacterials fit also happen when a resistance mechanism wey dey encoded by a single gene dey give resistance to more than one antibacterial compound. 