 
 <prompt> Wetin be di diffrensh between DNA and RNA? Based on di previus kweshon, write sometin wey get di ansa. E fit be 1 - 20 sentenses. Context: <response>: Additionally, genes fit get regulatory regions wey fit dey many kilobases upstream or downstream of the open reading frame. Dem dey act by binding to transcription factors wey go cause the DNA to loop so that the regulatory sequence (and bound transcription factor) go dey close to the RNA polymerase binding site. For example, enhancers dey increase transcription by binding an activator protein wey go help to recruit the RNA polymerase to the promoter; conversely silencers dey bind repressor proteins and make the DNA less available for RNA polymerase. 