 
 <prompt> Wetin dem dey call substance wey dey help bring biochemical reaction? <response>: Antibacterial-resistant strains and species, wey dem dey call "superbugs", dey add to di wahala wey dey come out as diseases wey don dey control before. For example, bacteria wey dey cause tuberculosis (TB) wey no dey gree for antibacterial treatments wey dey work before, dey bring plenty wahala for treatment. Every year, we dey estimate say almost half a million new cases of multidrug-resistant tuberculosis (MDR-TB) dey happen worldwide. For example, NDM-1 na enzyme wey dem just discover wey dey make bacteria no gree for plenty beta-lactam antibacterials. Health Protection Agency for United Kingdom don talk say "most isolates wey get NDM-1 enzyme no dey gree for all di normal intravenous antibiotics wey dem dey use treat serious infections." 