Main metabolic pathways involved in hamartoma predisposition syndromes (PJS: Peutz-Jeghers syndrome; CS/BRRS - Cowden syndrome/Bannayan-Ruvalcaba-Riley syndrome; TSC - tuberous sclerosis complex. PI3K – phosphoinositol kinase, PIP3 – phosphatidylinositol-3,4,5-triphosphate; PIP2 – phosphatidylinositol-4,5-bisphosphate; PTEN - phosphatase and tensin homolog; TSC1 and TSC2 - hamartin/tuberin complex; mTOR - mammalian target of rapamycin. Therapeuthic potential of rapamycin and other inhibitors of mTOR signalling is presented
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