Pathogens are recognized by complement C1q or immunoglobulin (IgG) that bind to microglia complement receptors (e.g., ITGAM/ITGB2) or Fc-receptors (e.g., FCGR1) that signal via the immunoreceptor tyrosine-based activation motif (ITAM)-containing adaptor molecules TYROBP or FCER1G, respectively. Alternatively, pathogens are directly recognized by classical innate immune receptors (e.g., TREM2) that require the interaction with TYROBP for further signaling. Proteins on this pathway have targeted assays available via the CPTAC Assay Portal
https://www.wikipathways.org/instance/WP3937
Kristina Hanspers, Eric Weitz, Alexander Pico, Daniela Digles, Denise Slenter