please read the patents for informatiom
Paul A J Janssen, US3080372 (1963 to RES LAB DR C JANSSEN, RESEARCH LABORATORIUM DR C JANSSEN).

Lyles-Eggleston M, Altundas R, Xia J, Sikazwe DM, Fan P, Yang Q, Li S, Zhang W, Zhu X, Schmidt AW, Vanase-Frawley M, Shrihkande A, Villalobos A, Borne RF, Ablordeppey SY. Design, synthesis, and evaluation of metabolism-based analogues of haloperidol incapable of forming MPP+-like species. J Med Chem. 2004 Jan 29;47(3):497-508. doi: 10.1021/jm0301033. PMID: 14736232.
Own work
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