Synovial Sarcoma X chromosome breakpoint-2 (SSX2) proteins are known to localize in nucleus and work as a transcriptional repressor. In addition, expression of SSX2 is frequently observed in melanoma, but the role of the gene has not been evaluated. Thus, researchers have used the principle of ectopic expression to express SSX2 to different cell lines including cancer model cells. They found important phenotypes of ectopic SSX2 expression that is involved in tumorigenesis: 1) immediate induction of genomic instability, 2) long-term support of tumor cell growth.