* Dedicated equipment is needed for precise continuous dosing (e.g. pumps), connections, etc.
* Start-up and shut-down procedures have to be established. 
* Scale-up of micro effects such as the high area to volume ratio is not possible and economy of scale may not apply. Typically, a scale-up leads to a dedicated plant.
* Safety issues for the storage of reactive material still apply.
The drawbacks have been discussed in view of establishing small scale continuous production processes by Pashkova and Greiner.