Although there may not be a precise elucidation of pancratistatin biological synthesis, there have been speculations on biosynthesis of narciclasine and lycoricidine that are very similar to pancratistatin in terms of structure. The biosynthesis is accomplished via synthesis from O-methylnorbelladine by para-para phenol coupling to obtain vittatine as an intermediate. Subsequent elimination of two carbon atoms and hydroxylations of vittatine then leads to narciclasine.