The Nevada Test Site (NTS), is a United States Department of Energy reservation located in southeastern Nye County, Nevada, about 65 miles (105 km) northwest of the city of Las Vegas. Formerly known as the Nevada Proving Grounds, the site was established on 11 January 1951 for the testing of nuclear devices, covering approximately  of desert and mountainous terrain. Nuclear testing at the Nevada Test Site began with a  bomb dropped on Frenchman Flat on 27 January 1951. Many of the iconic images of the nuclear era come from the NTS.
During the 1950s, the mushroom clouds from atmospheric tests could be seen for almost . The city of Las Vegas experienced noticeable seismic effects, and the distant mushroom clouds, which could be seen from the downtown hotels, became tourist attractions. St. George, Utah, received the brunt of the fallout of above-ground nuclear testing in the Yucca Flats/Nevada Test Site. Winds routinely carried the fallout of these tests directly through St. George and southern Utah. Marked increases in cancers, such as leukemia, lymphoma, thyroid cancer, breast cancer, melanoma, bone cancer, brain tumors, and gastrointestinal tract cancers, were reported from the mid-1950s through 1980.
From 1986 through 1994, two years after the United States put a hold on full-scale nuclear weapons testing, 536 anti-nuclear protests were held at the Nevada Test Site involving 37,488 participants and 15,740 arrests, according to government records. Those arrested included the astronomer Carl Sagan and the actors Kris Kristofferson, Martin Sheen, and Robert Blake.
The Nevada Test Site contains 28 areas, 1,100 buildings, 400 miles (640  km) of paved roads, 300 miles of unpaved roads, ten heliports, and two airstrips. The most recent test was a sub-critical test of the properties of plutonium, conducted underground on December 7, 2012.