Grb2 has been shown to interact with:
* ADAM15, 
* Abl gene, 
* Arachidonate 5-lipoxygenase, 
* B-cell linker, 
* BCAR1, 
* BCR gene, 
* Beta-2 adrenergic receptor, 
* C-Met, 
* CBLB, 
* CD117, 
* CD22, 
* CD28, 
* CDKN1B, 
* CRK, 
* Cbl gene, 
* Colony stimulating factor 1 receptor, 
* DCTN1, 
* DNM1, 
* Dock180, 
* Dystroglycan, 
* EPH receptor A2, 
* ETV6, 
* Epidermal growth factor receptor, 
* Erythropoietin receptor, 
* FRS2, 
* Fas ligand, 
* GAB1, 
* GAB2, 
* Glycoprotein 130, 
* Granulocyte colony-stimulating factor receptor, 
* HER2/neu, 
* HNRNPC,
* Huntingtin, 
* INPP5D, 
* IRS1, 
* ITK, 
* Janus kinase 1, 
* Janus kinase 2, 
* KHDRBS1, 
* Linker of activated T cells, 
* Lymphocyte cytosolic protein 2, 
* MAP2, 
* MAP3K1 
* MAP4K1, 
* MED28, 
* MST1R, 
* MUC1, 
* Mitogen-activated protein kinase 9, 
* NCKIPSD, 
* NEU3, 
* PDGFRB, 
* PIK3R1, 
* PLCG1, 
* PRKAR1A, 
* PTK2, 
* PTPN11, 
* PTPN12, 
* PTPN1, 
* PTPN6, 
* PTPRA, 
* RAPGEF1, 
* RET proto-oncogene, 
* SH2B1, 
* SH3KBP1, 
* SHC1, 
* SOS1, 
* Src, 
* Syk, 
* TNK2, 
* TrkA, 
* VAV1, 
* VAV2, 
* VAV3,  and
* Wiskott-Aldrich syndrome protein.