Calorie restriction, vitamin E, and increased glutathione appear to reduce or halt the production of lipofuscin.
The nootropic drug piracetam appears to significantly reduce accumulation of lipofuscin in the brain tissue of rats.
Other possible treatments:
*Centrophenoxine
*Acetyl-L-carnitine
*Ginkgo biloba
*Dimethylethanolamine
*Curcumin
Wet macular degeneration can be treated using selective photothermolysis where a pulsed unfocused laser predominantly heats and kills lipofuscin-rich cells, leaving untouched healthy cells to multiply and fill in the gaps. The technique is also used as a skin treatment to remove tattoos, liverspots, and in general make skin appear younger. This ability to selectively target lipofuscin has opened up research opportunities in the field of anti-aging medicine.
Soraprazan (remofuscin) has been found to remove lipofuscin from retinal pigment epithelial cells in animals. This opens up a new therapy option for the treatment of dry age-related macular degeneration and Stargardt disease, for which there is currently no treatment. The drug has now been granted orphan drug designation for the treatment of Stargardt disease by the European Medicines Agency.