According to a research study conducted Hutton, M et al, a missense mutation occurring on the 5 region of the RNA associated with the tau protein was found to be correlated with inherited dementia (known as FTDP-17). The splice-site mutations all destabilize a potential stem–loop structure which is most likely involved in regulating the alternative splicing of exon10 in chromosome 17. Consequently, more usage occurs on the 5 splice site and an increased proportion of tau transcripts that include exon 10 are created. Such drastic increase in mRNA will increase the proportion of Tau containing four microtubule-binding repeats, which is consistent with the neuropathology described in several families with FTDP-17, a type inherited dementia.