V. G. Khlopin’s work in this area concerns gas, volumetric, gravimetric and colorimetric analysis.
Gas analysis. V. G. Khlopin developed instruments for rapid assessment of the amount of helium and neon in gas mixtures (V. G. Khlopin, E. K. Gerling, 1932). These devices have simplified the analysis of noble gases so much that they have made it possible to include it in the general method of gas analysis.
Volumetric analysis. For the first time in the USSR, V. G. Khlopin introduced the method of differential reduction and differential oxidation with the simultaneous determination of several cations in a mixture (1922) and experimentally mastered the simultaneous determination of vanadium, iron and uranium - volumetric methods for the determination of vanadium and uranium were proposed.
Gravimetric analysis. V. G. Khlopin developed a quantitative method for separating tetravalent uranium in the form UFNHF/HO from hexavalent uranium and trivalent and divalent iron.
Colorimetric analysis. Scientists have proposed a method for determining small amounts of iridium in the presence of platinum.
Under the leadership of V.G. Khlopin, several methods of analysis were also developed: a volumetric method for determining small amounts of boron, a volumetric method for determining  and , gravimetric methods for determining uranium, a colorimetric method for determining fluorine, and others.