Ali Akbar Moosavi-Movahedi's research career has been mostly marked on thermodynamics of protein denaturation especially by surfactants, protein folding/unfolding, protein glycation, biophysics of molecular diabetes, amyloid and protein aggregation and fibrillation, bioactive peptides, nutraceuticals, functional foods  and artificial enzyme. He has been selected as the chair of UNESCO Chair on Interdisciplinary Research in Diabetes, University of Tehran which is mostly oriented in the area of oxidative stress and diabetes complications.
He has established a highly equipped BCL laboratory for collaborations and working with different international research groups.
Ali A. Moosavi-Movahedi has been one of the pioneering scientists in establishing the first PhD programs in Biochemistry and Biophysics in Iran. He has initiated a few science and technology institutional foundations in Iran. His publications include 20 books and numerous full research papers published mostly in international research journals, mainly around structural elucidation of proteins, enzymes, and DNA strands. He is the chair of Center of Excellence in Biothermodynamics  and national committee member of the International Science Council (ISC) (previous name: ICSU) at University of Tehran.
He is a member of a few national and international scientific societies and is currently the president of Iran Society of Biophysical Chemistry(ISOBC). Several awards are given to researchers by the society such as ISOBC Global Science Contribution for senior highly cited distinguished scientists, ISOBC for talented young (under 35 year) researcher, Moosavi-Movahedi Award for young (under 40 years) eminent PhD that confer to scientists in Annual ISOBC Congress. ISOBC is a member of the International Union of Biochemistry and Molecular Biology (IUBMB) and the European Biophysical Societies' Association (EBSA).
He is the founding member of the Federation of Iran Bioscience Societies (FIrBS), Universal Scientific Education and Research Network (USERN), Biochemical Society of Iran, Iranian Biology Society.
He is the Editor-in-Chief of a journal named "Science Cultivation," which publishes aimed popularization of science, policy research in science and technology, promotion of science, assisting managers and policymakers in scientific centers, steering the direction of research for scientific elites and innovators in science and technology. This Journal attempts to create the necessary context for cultivating and fertilizing new areas of sciences through monitoring, culture building, and scientific capacity building.
He supports organizing National, Regional, and International conferences in the field of Biophysical Chemistry, biothermodynamics, Biomolecular Sciences and also in the area of enculturing science and technology advancements.
He has published a new international book entitled "Rationality and Scientific Lifestyle for Health" Springer 2021.