* A miniature binary weapon is used in an assassination in the Frederick Forsyth novel The Devils Alternative'. It consists of two half-capsules, a non-resistant one containing potassium cyanide and an acid-resistant one containing hydrochloric acid. The substances mix after the halves are assembled and the seal between them is broken, and form hydrogen cyanide. The surplus acid eats through the capsule walls of the non-resistant half, and after a delay of several hours, the lethal content is released into the intestinal tract of whoever ingested it.  While technically possible, the assassination tool as discussed in the novel is presumably fictional. However, there are claims that in September 2003, the SVR (Russian Foreign Intelligence Service) prepared to assassinate Boris Berezovsky with a similar device.
* In the 10th and 11th episodes of the 6th season of TV-series Dexter are shown preparation and application of binary weapon consisting of two containers filled with DF and isopropyl alcohol. When mixed, the two substances form sarin.
* The 2002 movie xXx features a Soviet-made binary chemical weapon codenamed "Silent Night", after its supposed ability to render an area silent by killing its inhabitants. In the movie, the chemical was acquired by the terrorist group Anarchy-99, and their leader, Yorgi, plans to launch missiles containing Silent Night from an autonomous solar-powered submarine called Ahab, with the intent to sow chaos among civilized nations as they all blame each other for the attacks.
* Michael Crichtons 1972 novel Binary' uses a binary nerve agent "VZ" as the main plot device intended to kill the President of the United States, and indirectly most of the inhabitants of San Diego.