* Oxime compounds are used as antidotes for nerve agents. A nerve agent inactivates acetylcholinesterase by phosphorylation. Oxime compounds can reactivate acetylcholinesterase by attaching to phosphorus, forming an oxime-phosphonate, which then splits away from the acetylcholinesterase molecule. Oxime nerve-agent antidotes are pralidoxime (also known as 2-PAM), obidoxime, methoxime, HI-6, Hlo-7, and TMB-4. The effectiveness of the oxime treatment depends on the particular nerve agent used.
* Perillartine, the oxime of perillaldehyde, is used as an artificial sweetener in Japan.  It is 2000 times sweeter than sucrose.
* Diaminoglyoxime is a key precursor to various compounds containing the highly reactive furazan ring.
* Methyl ethyl ketoxime is a skin-preventing additive in many oil-based paints.
* Buccoxime and 5-methyl-3-heptanone oxime ("Stemone") are perfume ingredients.
*Fluvoxamine is used as an antidepressant.