In 1827, Claus became involved, as an assistant of Eduard Friedrich Eversmann, in the botanical research of the steppes of the rivers Ural and Volga. He later used the collected data in his work Flora der Wolgagegenden (Flora of the Volga Region).
In 1834, while still studying at the University of Tartu, Claus went into another botanic trip to the trans-Volga steppes – this time with chemistry professor Gebel. The results of this expeditions were published in 1837–1838.