In Nyāya Sūtra's Book 4, Chapter 1, verses 19–21, postulates God exists, states a consequence, then presents contrary evidence, and from contradiction concludes that the postulate must be invalid.
A literal interpretation of the three verses suggests that Nyāya school rejected the need for a God for the efficacy of human activity. Since human action and results do not require assumption or need of the existence of God, sutra IV.1.21 is seen as a criticism of the "existence of God and theism postulate". The context of the above verses includes various efficient causes. Nyāya Sūtra verses IV.1.22 to IV.1.24, for example, examine the hypothesis that "random chance" explains the world, after these Indian scholars had rejected God as the efficient cause.