Vancomycin is considered a last resort medication for the treatment of sepsis and lower respiratory tract, skin, and bone infections caused by Gram-positive bacteria. The minimum inhibitory concentration susceptibility data for a few medically significant bacteria are:
* S. aureus: 0.25 μg/mL to 4.0 μg/mL
* S. aureus (methicillin resistant or MRSA): 1 μg/mL to 138 μg/mL
* S. epidermidis: ≤0.12 μg/mL to 6.25 μg/mL