Trimethylboroxine is used in the methylation of various aryl halides through palladium-catalyzed Suzuki-Miyaura coupling reactions:
Another form of the Suzuki-Miyaura coupling reaction exhibits selectivity to aryl chlorides:
Boroxines have also been examined as precursors to monomeric oxoborane, HB≡O. This compound quickly converts back to the cyclic boroxine, even at low temperatures.