The above descriptions ignore the effects of Gβγ–signalling, which can also be important, in particular in the case of activated G-coupled GPCRs. The primary effectors of Gβγ are various ion channels, such as G-protein-regulated inwardly rectifying K channels (GIRKs), P/Q- and N-type voltage-gated Ca channels, as well as some isoforms of AC and PLC, along with some phosphoinositide-3-kinase (PI3K) isoforms.