Mixtures containing HFC-43-10mee can replace CFC-113 and perfluorocarbon (PFC) as solvents in cleaning systems because HFC-43-10mee does not harm the ozone layer, unlike CFC-113 and PFC. Various mixtures of HFC-43-10mee are commercially available for a variety of cleaning purposes. Examples of zeotropic solvents in cleaning processes include: 
* Zeotropic mixtures of HFC-43-10mee and hexamethyldisiloxane can dissolve silicones and are highly compatible with polycarbonates and polyurethane. They can be used to remove silicone lubricant from medical devices. 
* Zeotropic mixtures of HFC-43-10mee and isopropanol can remove ions and water from materials without porous surfaces. This zeotropic mixture helps with absorption drying. 
* Zeotropic mixtures of HFC-43-10mee, fluorosurfactant, and antistatic additives are energy-effiicient and environmentally safe drying fluids that provide spot-free drying.