The combination of vancomycin powder and povidone-iodine lavage has shown promise in reducing the risk of periprosthetic joint infection in hip and knee arthroplasties. In several studies, this combination was found to be more effective than vancomycin alone in preventing joint infection, with lower rates of infection and fewer adverse events. However, there is still a need for prospective randomized studies to confirm these findings and assess the long-term efficacy and safety of this treatment approach. The research directions are to determine the optimal dosage and timing of vancomycin and povidone-iodine lavage, as well as their potential synergistic effect, safety, and efficiency of this possible future treatment option in reducing the risk of periprosthetic joint infection in hip and knee arthroplasties.