Azines characteristically undergo hydrolysis to hydrazines.  The reaction proceeds by the intermediacy of a hydrazone:
:RC=N-N=CR  +  HO  →  RC=N-NH  +  RC=O
:RC=N-NH  +  HO  →  NH  +  RC=O
Azines have been used as precursors to hydrazones: 
:RC=N-N=CR  +  NH  →  2 RC=N-NH
They are also precursors to diazo compounds.
The coordination chemistry of azines (as ligands) has also been studied. 
Acetone is used to derivatize hydrazine into acetone azine for analysis by gas chromatography. This method is used to determine trace levels of hydrazine in drinking water and pharmaceuticals.