Pharmacokinetic properties (see table 3) are important when new drugs are developed.
Patients seek rapid onset of action to relief the headache. Relatively short t, good bioavailability and lipophilicity are pharmacokinetic properties that have been associated with rapid onset of action. It has been speculated that good ability to cross the blood brain barrier and relatively long terminal elimination half-life  may result in a lower incidence of headache recurrence. Sumatriptan and rizatriptan undergo first pass hepatic metabolism and result in lower bioavailability.
 = Elimination half-life;
t = Time to reach peak plasma drug concentration;
Cl = Renal Clearance;
LogD = Measure of lipophilicity at pH 7.4. Increasing number indicate greater solubility;
V  = Volume of distribution</small><br />