Thomas Shirley Hele, OBE, MD, FRCP (b Carlisle 24 October 1881 – d Cambridge 23 January 1953) was an academic in the 20th century.
Hele was educated at Carlisle Grammar School ; Sedbergh School; Emmanuel College, Cambridge (Fellow, 1911); and Barts. He was University Lecturer in Biochemistry from 1921; Tutor at Emmanuel from 1922 to 1935; its Master from 1935 to 1951; and Vice-Chancellor of the University of Cambridge from 1943 to 1945.