tert-Butyllithium is renowned for deprotonation of carbon acids (C-H bonds). One example is the double deprotonation of allyl alcohol. Other examples are the deprotonation of vinyl ethers.
In combination with n-butyllithiium, tert-butylllithium monolithiates ferrocene. tert-Butyllithium deprotonates dichloromethane:
Similar to n-butyllithium, tert-butyllithium can be used for lithium–halogen exchange reactions.