Togni reagent II is used for trifluoromethylation of organic compounds. For phenolates, the substitution takes place preferably in the ortho position. It is possible to obtain a second substitution by using an excess of Togni reagent II.
Reactions with alcohols yield the corresponding trifluoromethyl ethers.
Trifluoromethylation of alkenes is possible under copper catalysis.