The molecule has two electrophilic sites, the carbon and the S(VI) center.
CSI has been employed for the preparation of β-lactams, some of which are medicinally important. Thus, alkenes undergo a -cycloaddition to give the sulfonamide.  The SOCl group can be removed simply by hydrolysis, leaving the secondary amide.
Other reactions of CSI:
*Cycloaddition to alkynes to give 1,2,3-oxathiazine-2,2-dioxide-6-chlorides.
*Conversion of primary alcohols to carbamates.
*Conversion of carboxylic acids and the acid chlorides into nitriles.
*Preparation of N,N-disubstituted sulfamides, RNSONH
*Preparation of Burgess reagent