In the adult brain, the endocannabinoid system facilitates the neurogenesis of hippocampal granule cells. In the subgranular zone of the dentate gyrus, multipotent neural progenitors (NP) give rise to daughter cells that, over the course of several weeks, mature into granule cells whose axons project to and synapse onto  dendrites on the CA3 region.  NPs in the hippocampus have been shown to possess fatty acid amide hydrolase (FAAH) and express CB and utilize 2-AG.  Intriguingly, CB activation by endogenous or exogenous cannabinoids promote NP proliferation and differentiation; this activation is absent in CB knockouts and abolished in the presence of antagonist.