Trifluoroacetic acid is a corrosive strong acid but it does not pose the hazards associated with hydrofluoric acid because the carbon-fluorine bond is not labile.  TFA is harmful when inhaled, causes severe skin burns and is toxic for aquatic organisms even at low concentrations.
TFA's reaction with bases and metals, especially light metals, is strongly exothermic. The reaction with lithium aluminium hydride (LAH) results in an explosion.
TFA is a metabolic breakdown product of the volatile anaesthetic agent halothane. It is thought to be responsible for halothane induced hepatitis.