In nerve terminals, synaptic vesicles are produced quickly to compensate for their rapid depletion during neurotransmitter release. Their biogenesis involves segregating synaptic vesicle membrane proteins from other cellular proteins and packaging those distinct proteins into vesicles of appropriate size. Besides, it entails the endocytosis of synaptic vesicle membrane proteins from the plasma membrane.
Synaptoblastic and synaptoclastic refer to synapse-producing and synapse-removing activities within the biochemical signalling chain. This terminology is associated with the Bredesen Protocol for treating Alzheimers disease, which conceptualizes Alzheimers as an imbalance between these processes. As of October 2023, studies concerning this protocol remain small and few results have been obtained within a standardized control framework.