A typical reaction with dissolution involves a weak base, B, dissolving in an acidic aqueous solution.
This reaction is very important for pharmaceutical products. Dissolution of weak acids in alkaline media is similarly important.
The uncharged molecule usually has lower solubility than the ionic form, so solubility depends on pH and the acid dissociation constant of the solute. The term "intrinsic solubility" is used to describe the solubility of the un-ionized form in the absence of acid or alkali.
Leaching of aluminium salts from rocks and soil by acid rain is another example of dissolution with reaction: alumino-silicates are bases which react with the acid to form soluble species, such as Al(aq).
Formation of a chemical complex may also change solubility. A well-known example is the addition of a concentrated solution of ammonia to a suspension of silver chloride, in which dissolution is favoured by the formation of an ammine complex.
When sufficient ammonia is added to a suspension of silver chloride, the solid dissolves. The addition of water softeners to washing powders to inhibit the formation of soap scum provides an example of practical importance.