As the French Revolution gained momentum, attacks mounted on the deeply unpopular Ferme générale, and it was eventually abolished in March 1791. In 1792 Lavoisier was forced to resign from his post on the Gunpowder Commission and to move from his house and laboratory at the Royal Arsenal. On 8 August 1793, all the learned societies, including the Academy of Sciences, were suppressed at the request of Abbé Grégoire.
On 24 November 1793, the arrest of all the former tax farmers was ordered. Lavoisier and the other Farmers General faced nine accusations of defrauding the state of money owed to it, and of adding water to tobacco before selling it. Lavoisier drafted their defense, refuting the financial accusations, reminding the court of how they had maintained a consistently high quality of tobacco. The court, however, was inclined to believe that by condemning them and seizing the goods of the Farmers General, it would recover huge sums for the state. Lavoisier was convicted and guillotined on 8 May 1794 in Paris, at the age of 50, along with his 27 co-defendants.
According to popular legend, the appeal to spare his life, in order that he could continue his experiments, was cut short by the judge, Coffinhal: "La République na pas besoin de savants ni de chimistes; le cours de la justice ne peut être suspendu."' ("The Republic needs neither scholars nor chemists; the course of justice cannot be delayed.") The judge Coffinhal himself would be executed less than three months later, in the wake of the Thermidorian reaction.
Lavoisiers importance to science was expressed by Lagrange who lamented the beheading by saying: "Il ne leur a fallu quun moment pour faire tomber cette tête, et cent années peut-être ne suffiront pas pour en reproduire une semblable." ("It took them only an instant to cut off this head, and one hundred years might not suffice to reproduce its like.")