Chemogenetics and usage of DREADDs have allowed researchers to advance in biomedical research areas including many neurodegenerative and psychiatric conditions. Chemogenetics have been used in these fields to induce specific and reversible brain lesions and therefore, study specific activities of neuron population. Although chemogenetics offers specificity and high spatial resolution, it still faces some challenges when used in investigating neuropsychiatric disorders. Neuropsychiatric disorders usually have a complex nature where lesions in the brain have not been identified as the main cause. Chemogenetics has been used to reverse some of the deficits revolving such conditions; however, it has not been able to identify the main cause of neuropsychiatric diseases and cure these conditions completely due to complex nature of these conditions. Nevertheless, chemogenetics has been used successfully in a preclinical model of drug-resistant epilepsy, where seizures arise from a discrete part of the brain.