The Hiyama–Denmark coupling is the modification of the Hiyama coupling that does not require a fluoride additive to utilize organosilanols and organic halides as coupling partners. The general reaction scheme is shown below, showcasing the utilization of a Brønsted base as the activating agent as opposed to fluoride, phosphine ligands are also used on the metal center.
A specific example of this reaction is shown with reagents. If fluoride had been used, as in the original Hiyama protocol, the tert-butyldimethylsilyl (TBS) ether would have likely been destroyed.