MIKE 21C can be used for designing protection schemes against bank erosion, evaluating measures to reduce or manage shoaling, analyzing alignments and dimensions of navigation channels for minimizing capital and maintenance dredging, predicting the impact of bridge, tunnel and pipeline crossings on river channel hydraulics and morphology, optimizing restoration plans for habitat environment in channel floodplain systems, designing monitoring networks based on morphological forecasting.
Due to its accurate descriptions of the physical processes, MIKE 21C can simulate a braided river developing from a plane bed, which was illustrated by Enggrob & Tjerry (1998).