C-type lectin-like receptors (CLRs) contain one or more C-type lectin (Ca2+ dependent carbohydrate-binding lectin) domains. Example pairs include: 
* CD94/NKG2, expressed in NK and some T cells and interacts with the ligand HLA-E.
* Dendritic cell immunoreceptor (DCIR)/dendritic cell immunoactivating receptor (DCAR), characterized as a pair in mice, though no human DCAR has been identified.
* NKR-P1 (CD161) is a member of a paired receptor group in rodents, but the human genome contains only one, inhibitory receptor, NKRP1A (KLRB1).
* The Ly49 family in mice has been extensively studied for its role in NK activation using laboratory mice as a model organism, but has no homologous gene cluster in the human genome. The KIR family is the functional equivalent.