The main focus of George's research was centered on the mechanical implications of the thermal and photochemical organic reactions. His studies covered different areas of organometallic chemistry and he worked on electron transfer processes, organic reactions and functional group transformations. Thus he studied the organic reactions and functional group transformations, heterohexa-1, 3, 5-triene systems with regard to its electrocyclic reactions and the synthetic utility and phototransformations of dibenzobarrelenes. He also studied the picosecond laser flash photolysis techniques and the transient intermediates involved in photoreactions. He was noted for the original approach in his studies of hetero-aromatic systems.
George published his research through over 200 articles in peer-reviewed journals and guided a number of doctoral and post-doctoral scholars in their researches. He has contributed chapters to the Handbook of Chemistry and Physics, edited by C. N. R. Rao and his works have been cited by various authors in their publications. He pioneered photochemistry research at the National Institute for Interdisciplinary Science and Technology and established the Photochemistry Research Unit at the institution. He was a collaborator of C. N. R. Rao in popularizing science education at academic levels and is associated, as the executive director, with the Foundation for Capacity Building in Science (FCBS) initiative which promotes science education among Indian students through seminars and workshops. He also served as a member of the council of the Indian National Science Academy from 1989 to 1991.