* Manaus, Brazil is on the Rio Negro near its confluence with the Amazon (see Meeting of Waters). It is the chief port and a hub for the region's extensive river system.
* The Iguazú flows into the Paraná at the "Triple Frontier" (, ), the tripoint for Paraguay, Argentina, and Brazil.
* In Ciudad Guayana, Venezuela there is a confluence between Orinoco River and Caroní River.