2,6-Di-tert-butylpyridine is prepared by the reaction of tert-butyllithium with pyridine. The synthesis is reminiscent of the Chichibabin reaction.
Some related bulky pyridine compounds have been described, including 2,4,6-tri-t-butylpyridine and 2,6-di-tert-butyl-4-methylpyridine.