In cell adhesion laminin-111 and other isoforms are important proteins that anchor cells to the extracellular matrix (ECM). The linkage between cells and the ECM is formed by binding cell surface receptors to one end of the laminin α chain and binding ECM components to another region of the laminin. Globular domains (G-Domain) of the α chain are the regions on laminin-111 that allow the binding of integrins, glycoproteins, sulfated glycolipids and dystroglycan.