More recently, slightly elevated serum GGT has also been found to correlate with cardiovascular diseases and is under active investigation as a cardiovascular risk marker. GGT in fact accumulates in atherosclerotic plaques, suggesting a potential role in pathogenesis of cardiovascular diseases, and circulates in blood in the form of distinct protein aggregates,  some of which appear to be related to specific pathologies such as metabolic syndrome, alcohol addiction and chronic liver disease.
Elevated levels of GGT can also be due to congestive heart failure.