Another example is the combination of non-steroidal anti-inflammatory drugs (NSAIDs) and glucocorticoids. Although NSAIDs and glucocorticoids have different mechanisms of action, the drugs are able to diminish the protective effect of gastric mucosa from gastric acid. As a result, the concomitant use of NSAIDs and glucocorticoids increases the risk of gastric bleeding and worsens peptic ulcer disease. As a result, the combination of NSAIDs and glucocorticoids is not recommended.