The usual method of industrial production is the peroxide process, starting from the ketone, ammonia, and hydrogen peroxide.
In the laboratory, azines are typically prepared by condensation of hydrazine with two equivalents of a carbonyl.
Azines are also produced when chalcone reacts with a hydrazone to produce 3,5-diphenyl-1H-pyrazole, in a conversion also carried out with hydrazine hydrate.