There is no known antidote against MFA, but there are some suggestions regarding the treatment of MFA poisoning. Advised is to use an intravenous injection of fast-acting anesthetics directly after poisoning. The anesthetic should be pentothal sodium or evipan sodium followed by an intramuscular injection of long-acting cortical depressants like sodium phenobarbitone or rectal avertin. Afterward, careful supervision of oxygen supply is necessary together with a BLB mask and the use of artificial respiration. Possibly, the use of hypertonic glucose intravenously is required as in status epilepticus. At last, careful use of tubocurarine chloride should be applied to control any convulsions. If any vomiting occurs, lean the patient forward to maintain an open airway.
Alternatively, there is a therapy aimed at the prevention of fluorocitrate synthesis, the blocking of aconitase within the mitochondria, and to provide a citrate outflow from the mitochondria to keep the TCA cycle going. For now, ethanol has proven to be the most effective against FC formation. When ethanol is oxidized, it increases blood acetate levels which inhibits FC production. In humans, an oral dose of 40-60 mL 96% ethanol is advised followed by 1.0-1.5 g/kg of 5-10% ethanol intravenously during the first hour and 0.1 g/kg during the following 6–8 hours. This therapy is meant for fluoroacetate (FA) poisoning which is highly related MFA, so this therapy aimed at MFA may result in other outcomes.
Treatment with monoacetin (glycerol monoacetate) helped against FA poisoning. It aids in increasing acetate levels of the blood and it decreases citrate levels in the heart, brain, and kidneys. However, this is only tested experimentally. In monkeys, monoacetin even reverses the effects of FA: all biological effects normalized. As with ethanol, monoacetin is effective against FA poisoning.
There is up until now, no proven treatment against MFA. However, the beforementioned treatments can provide starting points for therapy aimed at MFA since FA and MFA are closely related compounds.