In the last years, in silico medicine turned out to be promising, aiding scientists and clinicians to prevent and adequately cure several diseases. Computational modeling aid in understanding complex phenomena, allowing scientists to vary parameters aiming to measure variables that otherwise could have not been investigated.
In the field of electrophysiology, the pharmacological cardiotoxicity assessment can be carried out leveraging specific computational models. According to the type and parameters to be investigated in the research, it is possible to analyze the pharmacological effect on the atria and ventricles separately.
Since the two cardiac chambers are very different each other and play a key role both on a functional and anatomical basis, suitable computational models have to be accounted for to describe their different behaviour. During the years, several models have been developed o best characterize and replicate the cellular action potential behaviour of the most relevant anatomical region of the heart, such as Courtemanche model for atria or O'Hara model for ventricles.