In 1997, Myles and his co-workers  has described the total synthesis of (-)-discodermolide using chelation-controlled alkylation as the key coupling. The titanium-mediated hetero-Diels–Alder reaction of aldehyde with the Danishefsky diene successfully produced the challenging Z-trisubstituted C(13)–C(14) olefin in allylic iodide fragment. The stereogenicity in the C(16)–C(21) subunit was induced by employing Evans
aldol chemistry. The stereogenicity of the final fragment was set by a tin-promoted asymmetric allylation. Notably, the correct oxidation state at C(1) of this fragment would reduce the number of steps after the coupling of fragments. The Myles synthesis of (-)-discodermolide has an overall yield of 1.5% with a longest linear sequence of 25 steps and 44 total steps.