One of the main applications of static light scattering for molecular mass determination is in the field of macromolecules, such as proteins and polymers, as it is possible to measure the molecular mass of proteins without any assumption about their shape. Static light scattering is usually combined with other particle characterization techniques, such as size-exclusion chromatography (SEC), dynamic light scattering (DLS), and electrophoretic light scattering (ELS).