An intense effort has been made towards the total synthesis of (+)-discodermolide in order to meet the growing interest of studying its clinical profile. More than a dozen of syntheses have been published by different research groups. After decade of work, discodermolide syntheses have become more convergent and more practical. All of the total syntheses approaches started with the construction of three major fragments of roughly equivalent complexity, each of which contains the methyl-hydroxyl-methyl triad of contiguous centers that matches the stereogenicity of discodermolide target. Here are three examples of the retrosynthetic analyses of (+)-discodermolide: