Late transition metals from groups 10, 11, and 12 when placed at the anomeric carbon show strong axial preferences. This phenomenon termed as the metallo-anomeric effect originates from stabilizing hyperconjugative interactions between oxygen or other heteroatoms with lone pairs and C-M anti-bonding orbitals that act as good acceptors. The generalized metallo-anomeric effect refers to thermodynamic stabilization of synclinal conformers of compounds with the general formula M-CH-OR. Axial/equatorial preferences can be influenced by ligands attached to the metal and electronic configuration. In general terms, moving from a lighter to a heavier element in the group, the magnitude of the metallo-anomeric effect increases. Furthermore, higher oxidation states favor axial/synclinal conformers.