According to pharmacokinetic and pharmacodynamic data of the drugs, the pharmacological action is integrated in the model. By means of specific electrical stimuli protocols, the pharmacological effect of a new drug can be investigated in a completely safe, and controlled computational environment, providing preliminary important considerations concerning the cardiotoxicity of new pharmacological compounds.
According to the outcome of the simulations, several aspects can be investigated to identify the pro-arrhythmicity of a new pharmacological compound. The typical changes, called repolarization abnormalities, in the action potential morphology that are considered pro-arrhythmic are:
* Early afterdepolarization
* Electrical alternans
* Repolarization failures