In liquid chromatography: 
* Charged aerosol detector electrically charged aerosol is used for the detection of non-UV-absorbing chargeable molecules, especially saccharides and lipids
* Evaporative light scattering detector evaporating non volatile solutes inside a volatile mobile phase for universal detection. used for saccharides and lipids and other non-UV-absorbing molecules
In gas chromatography:
* Flame ionization detector which uses ionizing flame to detect most hydrocarbon molecules
* Flame photometric detector which uses atomizing flame to get light emitted from specific elements to detect and quantify them
* Nitrogen Phosphorus Detector a thermionic detector with photometeric detection, sensitive specifically to nitrogen and phosphorus hydrocarbons
* Atomic-emission detector is a hyphenation between gas chromatography and atomic emission spectrophotometer for detection of elements.
In all types of chromatography:
* Mass spectrometer is in fact hyphenation between the separative instrument and a mass spectrometry instrument to get information on the molecular weight or atomic weight of the solute. In the advanced mass spectrometry technologies there is information on solutes structure and even chemical properties. The hyphenation between ultra high performance chromatography with high resolution mass spectrometers revolutionalized entire new scientific fields of research and application, such as toxicology, proteomics, lipidomics, genomics, metabolomics and metabonomics.