There have been many variations on the original composition which was Food and Drug Administration (FDA) approved and termed Bioglass. This composition is known as Bioglass 45S5. The compositions include:
* 45S5: 45 wt% SiO, 24.5 wt% CaO, 24.5 wt% NaO and 6.0  wt% PO. Bioglass
* S53P4: 53 wt% SiO, 23 wt% NaO, 20 wt% CaO and 4 wt% PO.
* 58S: 58 wt% SiO, 33 wt% CaO and 9 wt% PO.
* 70S30C: 70 wt% SiO, 30 wt% CaO.
* 13-93: 53 wt% SiO, 6 wt% NaO, 12 wt% KO, 5 wt% MgO, 20 wt% CaO, 4 wt% PO.