A parasympatholytic agent is a substance or activity that reduces the activity of the parasympathetic nervous system. 
The term parasympatholytic typically refers to the effect of a drug, although some poisons act to block the parasympathetic nervous system as well. Most drugs with parasympatholytic properties are anticholinergics.
Parasympatholytic agents and sympathomimetic agents have similar effects to each other, although some differences between the two groups can be observed. For example, both cause mydriasis, but parasympatholytics reduce accommodation (cycloplegia), whereas sympathomimetics do not.
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