The same molecular-kinetic picture of a single component gas can also be applied to a gaseous mixture. For instance, in the Chapman–Enskog approach the viscosity  of a binary mixture of gases can be written in terms of the individual component viscosities , their respective volume fractions, and the intermolecular interactions. 
As for the single-component gas, the dependence of  on the parameters of the intermolecular interactions enters through various collisional integrals which may not be expressible in closed form. To obtain usable expressions for  which reasonably match experimental data, the collisional integrals may be computed numerically or from correlations. In some cases, the collision integrals are regarded as fitting parameters, and are fitted directly to experimental data. This is a common approach in the development of reference equations for gas-phase viscosities. An example of such a procedure is the Sutherland approach for the single-component gas, discussed above.
For gas mixtures consisting of simple molecules, Revised Enskog Theory has been shown to accurately represent both the density- and temperature dependence of the viscosity over a wide range of conditions.