Although the ancient atomists works were unavailable, scholastic thinkers still had Aristotles critiques of atomism. Although the atomism of Epicurus had fallen out of favor in the centuries of Scholasticism, the minima naturalia of Aristotelianism received extensive consideration. Speculation on minima naturalia provided philosophical background for the mechanistic philosophy of early modern thinkers such as Descartes, and for the alchemical works of Geber and Daniel Sennert, who in turn influenced the corpuscularian alchemist Robert Boyle, one of the founders of modern chemistry. 
A chief theme in late Roman and Scholastic commentary on this concept was reconciling minima naturalia with the general Aristotelian principle of infinite divisibility. Commentators like John Philoponus and Thomas Aquinas reconciled these aspects of Aristotle's thought by distinguishing between mathematical and "natural" divisibility. With few exceptions, much of the curriculum in the universities of Europe was based on such Aristotelianism for most of the Middle Ages.