Since IEC and HIC conditions are the closest ones to physiological conditions which are fit for maintaining biological activity, the combinations of them are widely used in the separation of biological products. IEC/HIC MMC has improved separation power and selectivity on the grounds that it applies both electrostatic and hydrophobic interactions.  One such example is [http://www.bio-rad.com/en-us/product/mixed-mode-media/nuvia-cprime-media Nuvia(tm) cPrime(tm)], from [http://www.bio-rad.com/ Bio-Rad Laboratories].