In early 2004, Schadler, Garde, and Siegel were awarded a U.S. National Science Foundation grant to make a new Molecularium show exclusively for an immersive dome based video display environment, also known as a fulldome medium. They recruited filmmaker, and experience designer, V. Owen Bush to bring the idea to life. Bush founded the production company Nanotoon Entertainment with writer/producer Kurt Przybilla to realize the new project. Bush and Przybilla proposed an adventure story of personified atoms flying a ship called the Molecularium through nanoscale materials including a snowflake, a penny, a stick of gum and the human body.
In February 2005, the team debuted "Molecularium - Riding Snowflakes" a 23-minute digital planetarium show at the Children's Museum of Science and Technology. In 2005, "Molecularium - Riding Snowflakes" won the Domie award at Domefest, a festival for immersive dome films, in Albuquerque New Mexico. "Molecularium - Riding Snowflakes" has shown at Chabot Space and Science Center in Oakland, California, the Newark Museum Planetarium in Newark, New Jersey, Dubai Children’s City, UAE, and Thinktank, Birmingham, UK, among other digital planetariums. It has been translated and versioned in Arabic, Korean and Turkish. It is Distributed by E&S, Spitz, Sky-Skan, and e-Planetarium.
In 2010, the American Library Association (ALA) selected the Molecularium Kid's Site for inclusion to its Great Websites for Kids.