Trisoxazolines have been used for the copper catalysed Friedel–Crafts alkylation of indoles, largely with alkylidene malonates, with good yields and ee's reported. A number of interesting solvent effects have also been observed, including a relationship between enantioselectivity and the steric bulk of the solvent when using of alcohols and a reversal of enantioselectivity when changing the reaction solvent from coordinating solvents to weakly coordinating solvents.