With non-covalent imprinting, interaction forces between template molecule and functional monomer are the same as the interaction forces between the polymer matrix and analyte. The forces involved in this procedure can include hydrogen bonds, dipole dipole interactions, and induced dipole forces. This method is the most widely used approach to create MIPs due to easy preparation and the wide variety of functional monomers that can be bound to the template molecule. Among the functional groups, methacrylic acid is the most commonly used compound due to its ability to interact with other functional groups. Another way to alternate the non-covalent interaction between the template molecule and polymer is through the technique ‘bite and switch’ developed by Professor Sergey A. Piletsk<nowiki/>y and Sreenath Subrahmanyam. In this process, functional groups first non-covalently bond with the binding site, but during the rebinding step, the polymer matrix forms irreversible covalent bonds with the target molecule.