Animal based approaches to phenotypic screening are not as amenable to screening libraries containing thousands of small molecules.  Therefore, these approaches have found more utility in evaluating already approved drugs or late stage drug candidates for drug repositioning.
A number of companies including Melior Discovery, Phylonix, and Sosei have specialized in using phenotypic screening in animal disease models for drug positioning. Many other companies are involved in phenotypic screening research approaches, including Eurofins Discovery Phenotypic Services, Evotec, Dharmacon, Inc., ThermoScientific, Cellecta, and Persomics.