Homochirality is the geometric uniformity of materials composed of chiral (non-mirror-symmetric) units. Living organisms use molecules that have the same chirality (handedness): with almost no exceptions, amino acids are left-handed while nucleotides and sugars are right-handed. Chiral molecules can be synthesized, but in the absence of a chiral source or a chiral catalyst, they are formed in a 50/50 (racemic) mixture of both forms. Known mechanisms for the production of non-racemic mixtures from racemic starting materials include: asymmetric physical laws, such as the electroweak interaction; asymmetric environments, such as those caused by circularly polarized light, quartz crystals, or the Earth's rotation, statistical fluctuations during racemic synthesis, and spontaneous symmetry breaking.
Once established, chirality would be selected for. A small bias (enantiomeric excess) in the population can be amplified into a large one by asymmetric autocatalysis, such as in the Soai reaction. In asymmetric autocatalysis, the catalyst is a chiral molecule, which means that a chiral molecule is catalyzing its own production. An initial enantiomeric excess, such as can be produced by polarized light, then allows the more abundant enantiomer to outcompete the other.
Homochirality may have started in outer space, as on the Murchison meteorite the amino acid L-alanine is more than twice as frequent as its D form, and L-glutamic acid is more than three times as abundant as its D counterpart. Amino acids from meteorites show a left-handed bias, whereas sugars show a predominantly right-handed bias, as found in living organisms, suggesting an abiogenic origin of these compounds.
In 2010, an experiment by Robert Root-Bernstein shows that "two D-RNA-oligonucleotides having inverse base sequences (D-CGUA and D-AUGC) and their corresponding L-RNA-oligonucleotides (L-CGUA and L-AUGC) were synthesized and their affinity determined for Gly and eleven pairs of L- and D-amino acids". This suggests that homochirality, including codon directionality, might have "emerged as a function of the origin of the genetic code".