The main advantages for SRCD over lab-based cCD machines arise from the use of the synchrotron light emission as the source.  A number of biologically interesting absorption bands are found in the region between ~170 nm and ~350 nm.  For proteins these come from their secondary and tertiary structures, while structural bands for nucleic acids, (DNA and RNA), and saccharides are also located in this region.  However, for cCD machines the photon flux from the source reduces by around two orders of magnitude in the wavelength range from 250 nm down to 180 nm, exactly in the region of most significance for these biological molecules.  By contrast, typically, the photon flux for an SRCD beamline in this region is at least three orders of magnitude higher than a cCD machine, retaining that level down to ~150 nm.  The increased flux means the measured signals from the sample will be increased relative to the background noise, so there is a significant improvement in the signal-to-noise ratio of the sample.  This will improve the accuracy of the data recorded meaning interpretation can be undertaken with more confidence in the results.  A further advantage of the increased flux is that the concentration of the sample can be reduced while still retaining a significant increase in signal strength, so samples that are difficult to produce in quantity have more chance of producing usable CD data from SRCD rather than a cCD machine. Increasing the lower wavelength range provides more spectral data for analysis which means there is more information content available in that data, meaning that more parameters, here secondary structure features in the protein structure, can be accurately determined.