The tripartite motif is always present at the N-terminus of the TRIM proteins. The TRIM motif includes the following three domains:
* (1) a RING finger domain
* (2) one or two B-box zinc finger domains
** when only one B-box is present, it is always a type-2 B-box
** when two B-boxes are present the type-1 B-Box always precedes the type-2 B-Box
* (3) coiled coil region
The C-terminus of TRIM proteins contain either:
* Group 1 proteins: a C-terminal domain selected from the following list:
** NHL and IGFLMN domains, either in association or alone
** PHD domain associated with a bromodomain
** MATH domain (in e.g., TRIM37)
** ARF domain (in e.g., TRIM23)
**  EXOIII domain (in e.g., TRIM19) or
* Group 2 proteins: a SPRY C-terminal domain
**e.g. TRIM21