The TRIM family is split into two groups that differ in domain structure and genomic organization:
* Group 1 members possess a variety of C-terminal domains, and are represented in both vertebrate  and invertebrates
* Group 2 is absent in invertebrates, possess a C-terminal SPRY domain
Members of the family include:
* Group 1
** PHD-BROMO domain containing: TRIM24 (TIF1α), TRIM28 (TIF1β), TRIM33 (TIF1γ)–  act as corepressors
**   1-10:   TRIM1, TRIM2, TRIM3,  TRIM8, TRIM9
** 11-20: TRIM12, TRIM13, TRIM14, TRIM16, TRIM18, TRIM19
** 21-30: TRIM23, TRIM25,  TRIM29, TRIM30
** 31-40:  TRIM32, TRIM36, TRIM37
** 41-50:  TRIM42, TRIM44, TRIM45, TRIM46, TRIM47
** 51-60: TRIM51, TRIM53, TRIM54, TRIM55, TRIM56, TRIM57, TRIM59
** 61-70:  TRIM62, TRIM63, TRIM65, TRIM66, TRIM67, TRIM69, TRIM70
** 71-75: TRIM71
* Group 2
**  1-10: TRIM4, TRIM5, TRIM6, TRIM7, TRIM10
** 11-20: TRIM11, TRIM12, TRIM15, TRIM17, TRIM20
** 21-30: TRIM21, TRIM22, TRIM26, TRIM27, TRIM30
** 31-40: TRIM31, TRIM34, TRIM35, TRIM38, TRIM39, TRIM40
** 41-50: TRIM41, TRIM43, TRIM48, TRIM49, TRIM50
** 51-60: TRIM51, TRIM52, TRIM53, TRIM57, TRIM58, TRIM60
** 61-70: TRIM61, TRIM64, TRIM68, TRIM69, TRIM70
** 71-75: TRIM72, TRIM73, TRIM74, TRIM75