Phoslactomycin (PLM) is a natural product from the isolation of Streptomyces species. This is an inhibitor of the protein serine/threonine phosphatase which is the protein phosphate 2A (PP2A). The PP2A involves the growth factor of the cell such as to induce the formation of mitogen-activated protein interaction and playing a role in cell division and signal transduction. Therefore, PLM is used for the drug that prevents the tumor, cancer, or bacteria. There are nowsaday has 7 kinds of different PLM from PLM A to PLM G which differ the post-synthesis from the biosynthesis of PLM.
Phoslactomycin B (PLM B) is the product of the post synthase of the biosynthesis of phoslactomycin and the intermediate to produce the other PLMs. The biosynthesis of phoslactomycin belongs to type I polyketide synthase (PKS). A polyketide is are characterized by a macrocyclic lactone and is produced by bacteria and fungi. From the PLM B, there are many articles wrote about the synthesis of different PLM A through PLM G.