There are 30 isoforms of FAM227B and one paralog, FAM227A. The conserved domains in these isoforms (as well as the paralog) are of various sizes and encode the protein FWWh (pfam14922) of unknown function, which all contain the distinctive motif FWW with a hydrophobic residue h. The main isoform used for analysis of FAM227B is isoform 1 (NM_152647.3). The next most reliable isoform of FAM227B is isoform 2 ( NM_001330293.2). The second isoform is shorter and has a distinct C-terminus.
Below are cartoons depicting the different lengths and cutting patterns of the isoforms*:
The cartoons do not precisely depict differences between all the isoforms, but instead act as a simple depiction of a larger pattern between the isoforms.