As of 2012, she is a full professor of inorganic chemistry and head of the research group Smart Biomaterials in the Department of Inorganic and Bioinorganic Chemistry of the Faculty of Pharmacy at Universidad Complutense de Madrid. 
Vallet-Regí has written more than 600 articles and several books. She was the most-cited Spanish scientist, according to ISI Web of Knowledge, in the field of Materials Science in these past decades.