The advent of Wacker Process has spurred on many investigations into the utility and applicability of the reactions to more complex terminal olefins. The Tsuji-Wacker oxidation is the palladium(II)-catalyzed transformation of such olefins into carbonyl compounds. Clement and Selwitz were the first to find that using an aqueous DMF as solvent allowed for the oxidation of 1-dodecene to 2-dodecanone, which addressed the insolubility problem of higher order olefins in water. Fahey noted the use of 3-methylsulfolane in place of DMF as solvent increased the yield of oxidation of 3,3-Dimethylbut-1-ene. Two years after, Tsuji applied the Selwitz conditions for selective oxidations of terminal olefins with multiple functional groups, and demonstrated its utility in synthesis of complex substrates. Further development of the reaction has led to various catalytic systems to address selectivity of the reaction, as well as introduction of intermolecular and intramolecular oxidations with non-water nucleophiles.