In addition to the nature of the detected signal, other implementations in this platform allows for an even higher signal-to-noise ratio.  In the case of magnetic sequencing by hybridization, a set of overlapping tiles is used such that the sequence of each nucleotide is determined by the hybridization of an 8-mer.  Therefore, the instrument only requires the sensitivity to detect a change of ~ 6 nm (the length of 8 nucleotides).  Similarly, for sequencing by ligation cycles, successful incorporation is characterized by a ~5 nm increase (ligation of a 7-mer) followed by a ~ 4 nm decrease (RNase cleavage of 6-mer) in hairpin length. In this case, the decrease in length in the second step provides additional confirmation for the obtained signal.