In 2008, Ardisson and his co-workers reported a strategy that applies a crotyltitanation reaction repeatedly to yield homoallylic (Z)-O-ene-carbamate alcohols with excellent selectivity. This crotyltitanation reaction not only efficiently produces the syn-anti methyl-hydroxy-methyl triads of (+)-discodermolide, but also yields products that can be easily converted to terminal (Z)-diene. The C13-C14 (Z)-olefin is installed through a highly selective dyotropic rearrangement.  The Ardission synthesis of (+)-discodermolide has an overall yield of 1.6% with a longest linear sequence of 21 steps.