Paucimannosidic proteins have been reported in vertebrates such as quail, chicken and in mammals, encompassing a limited diversity of paucimannosidic glycan structures. Early findings reported on paucimannosidic glycans on lysosomal glycoproteins in domestic animals. and human tissues, but have subsequently been found also to decorate non-lysosomal glycoproteins. Particularly, the granules of human neutrophils are a principal source of paucimannosidic proteins. Paucimannosidic proteins were also observed in human monocytes and macrophages and paucimannosidic immunoglycopeptides were found to be presented by SARS-CoV-2 challenged dendritic cells. Species within other classes under Animalia related to vertebrates were also documented to express paucimannosidic proteins. with some observations of unusual plant- and invertebrate-like paucimannosidic glycan structures