G stimulates the membrane-bound phospholipase C beta, which then cleaves PIP (a minor membrane phosphoinositol) into two second messengers, IP3 and diacylglycerol (DAG).
The Inositol Phospholipid Dependent Pathway is used as a signal transduction pathway for many hormones including:
* ADH (Vasopressin/AVP) – Induces the synthesis and release of glucocorticoids (Zona fasciculata of adrenal cortex); Induces vasoconstriction (V1 Cells of Posterior pituitary)
* TRH – Induces the synthesis and release of TSH (Anterior pituitary gland)
* TSH – Induces the synthesis and release of a small amount of T4 (Thyroid Gland)
* Angiotensin II – Induces Aldosterone synthesis and release (zona glomerulosa of adrenal cortex in kidney)
* GnRH – Induces the synthesis and release of FSH and LH (Anterior Pituitary)