Capnellene-8β,10α-diol and its acylated derivatives exhibit significant cytotoxicity in vitro against cervical epitheloid carcinoma (HeLa, oral epidermoid (KB), medulloblastoma (Daoy) and colon adenocarcinoma (WiDr) human tumor cell lines. The diol was also effective against human leukemia, renal leiomyoblastoma, colon and breast cancer cell lines. In the same study, capnellene-8β-ol demonstrated selective toxicity for the renal leiomyoblastoma and ovarian cancer cell lines, while 3β-acetoxycapnellene-8β,10α,14β-triol was active against leukemia cell lines. The antitumor properties of capnellene derivatives have yet to be explored in vivo.