Tripotassium phosphate has few industrial applications.
It is used as an inert, easily removed proton acceptor in organic synthesis. Some of the reactions are listed below:
# The hydrate () has been used to catalyze the deprotection of BOC amines. Microwave radiation is used to aid the reaction.
# As a catalyst for the synthesis of unsymmetrical diaryl ethers using [Bmim] as the solvent. Aryl methane-sulfonates are deprotected and then followed by a nucleophilic aromatic substitution (SAr) with activated aryl halides.
# As a base in the cross-coupling reaction of aryl halides with terminal alkynes. It also plays a role in the deacetonation of 4-aryl-2-methylbut-3-yn-2-ol intermediates.
# As the base in the cross-coupling reaction between aryl halides and phenols or aliphatic alcohols.