The first event appears to be the accumulation of cell adhesion molecules such as NF186 or NrCAM.  The intra-cellular regions of these cell-adhesion molecules interact with ankyrin G, which serves as an anchor for sodium channels.  At the same time, the periaxonal extension of the glial cell wraps around the axon, giving rise to the paranodal regions.  This movement along the axon contributes significantly to the overall formation of the nodes of Ranvier by permitting heminodes formed at the edges of neighboring glial cells to fuse into complete nodes. 
Septate-like junctions form at the paranodes with the enrichment of NF155 in glial paranodal loops.  Immediately following the early differentiation of the nodal and paranodal regions, potassium channels, Caspr2 and TAG1 accumulate in the juxta-paranodal regions. This accumulation coincides directly with the formation of compact myelin. In mature nodal regions, interactions with the intracellular proteins appear vital for the stability of all nodal regions.  In the CNS, oligodendrocytes do not possess microvilli, but appear capable to initiate the clustering of some axonal proteins through secreted factors.  The combined effects of such factors with the subsequent movements generated by the wrapping of oligodendrocyte periaxonal extension could account for the organization of CNS nodes of Ranvier.