The sum activity of peripheral deiodinases (G, also referred to as SPINA-GD) is reduced in nonthyroidal illness with hypodeiodination.
G is obtained with
or
: Dilution factor for T3 (reciprocal of apparent volume of distribution, 0.026 L)<br />
: Clearance exponent for T3 (8e-6 sec)<br />
K: Dissociation constant of type-1-deiodinase (5e-7 mol/L)<br />
K: Dissociation constant T3-TBG (2e9 L/mol)