Blood based protein biomarkers are often used as a diagnostic test that usually monitor one or more protein that are indicative of the presence of  disease or disorder or the presence of a disease/disorder subphtnotype.  Such a Blood based protein biomarker-based test can aoften be used Bas prognosticator of disease outcome. An example is neuronal Ubiquitin carboxy-terminal hydrolase L1 (UCH-L1) and  Glial fibrillary acidic protein (GFAP)  can aid in the diagnosis of the presence a cranial lesion among moderate to mild TBI patients that is otherwise only diagnosable with the use of a CT scan of the head.