The YoctoReactor (yR) is a 3D proximity-driven approach which exploits the self-assembling nature of DNA oligonucleotides into 3, 4 or 5-way junctions to direct small molecule synthesis at the center of the junction. Figure 5 illustrates the basic concept with a 4-way DNA junction.
The center of the DNA junction constitutes a volume on the order of a yoctoliter, hence the name YoctoReactor.  This volume contains a single molecule reaction yielding reaction concentrations in the high mM range.  The effective concentration facilitated by the DNA greatly accelerates chemical reactions that otherwise would not take place at the actual concentration several orders of magnitude lower.