The European Medicines Agency (EMA) has concluded that the extract of the natural product Saw palmetto can be used to treat symptoms of benign prostatic hyperplasia (BPH) as research has shown its 5-ARI effects. An extract of Serenoa repens, also known as saw palmetto extract, is a 5-ARI that is sold as an over-the-counter dietary supplement. It is also used under the brand name Permixon in Europe as a pharmaceutical drug for the treatment of benign prostatic hyperplasia.