Several synthetic molecular knots have been reported. Knot types that have been successfully synthesized in molecules are and 8 knots. Though the  and  knots have been found to naturally occur in knotted molecules, they have not been successfully synthesized. Small-molecule composite knots have also not yet been synthesized.
Artificial DNA, RNA, and protein knots have been successfully synthesized. DNA is a particularly useful model of synthetic knot synthesis, as the structure naturally forms interlocked structures and can be easily manipulated into forming knots control precisely the raveling necessary to form knots. Molecular knots are often synthesized with the help of crucial metal ion ligands.