Drahoš considers himself a centrist politician. As a candidate, Jiří Drahoš has presented himself as someone who can unite society, and as a respectable person who would act according to the constitution. Drahoš emphasises the importance of Czech science and education and has called for solidarity with those "who cannot take care of themselves". He has called for a "responsible approach" to the landscape and environment and has described human reason, creativity and ingeniousness as the only "renewable resource" of the wealth of the Czech Republic.
Drahoš wants the Czech Republic to play an active role in discussions over the future of the European Union, and wants the country to be a part of the Western world. He supports European integration but has said that he believes that the European Union should not impose unnecessary regulations on member states. He also said that he would not rush into Czech adoption of the Euro. Drahoš opposes a referendum about Czech membership of the European Union, and said that important geopolitical questions should not be decided by referendum. He supports the Czech Republic's membership of NATO.
In August 2015, Drahoš signed a petition named "scientists against fear and apathy" in opposition to both anti-Islamic radicalism and anti-immigrant populism.
Drahoš suggested that the Catalan independence referendum was "not legal", supporting the position of the Spanish government.
Drahoš says he supports the anti-Russian sanctions imposed by the United States and the EU. However he also said that having good relations with Russia is in the interest of the Czech Republic and European Union. Drahoš supports trade and economic relations with China, arguing that "China is a superpower" and "many countries are doing business with China."
In 2017, Drahoš rejected the European Unions proposal of compulsory migrant quotas, saying, "there is no successful model of Muslim integration in Europe". Drahoš also said that "Europe cant feed 100 million Africans, it is necessary to help them at home."
Drahoš described the pre-war German minority in Czechoslovakia as "Adolf Hitler's fifth column", and said that he agreed with the post-war expulsion of Germans from Czechoslovakia.
Drahoš has described himself as a sympathizer with Israel.