M. V. George, born on 3 October 1928 in the south Indian state of Kerala, graduated in chemistry from Madras University in 1948 and moved to the Dr. Bhimrao Ambedkar University (then known as Agra University) from where he secured his masters degree in 1951. He did his doctoral studies at St. Johns College, Agra of Agra University under the guidance of P. I. Ittyerah, a former principal of the college, and after securing PhD in 1954, he did his post-doctoral studies at various colleges in the US, UK, Germany and Canada.
He returned to India in 1963 and started his career as a member of faculty at the Indian Institute of Technology, Kanpur. He stayed at the institution for quarter of a century until 1988 during which period he headed the Department of Chemistry from 1966 to 1969, succeeding C. N. R. Rao. Returning to his home state of Kerala in 1988, he joined the Regional Research Laboratory of the Council of Scientific and Industrial Research (present-day National Institute for Interdisciplinary Science and Technology) as an emeritus professor and served the institution until his superannuation from service. In between, he had various stints at the University of Notre Dame as a visiting professor during 1978–2001.