The Orbitrap is a high-resolution Fourier transform mass spectrometer that has recently been adapted to allow for site-specific analyses. Molecules introduced into the Orbitrap are fragmented, accelerated, and analyzed. Because the Orbitrap characterizes molecular masses by measuring oscillations at radio frequencies, it is able to reach very high levels of precision, depending on measurement method (i.e., down to 0.1 per mille for long integration times). It is significantly faster than site-specific isotope measurements that can be performed using NMR, and can measure molecules with different rare isotopes but the same nominal mass at natural abundances (unlike GC and LCMS). It is also widely generalizable to molecules that can be introduced via gas or liquid solvent. Resolution of the Orbitrap is such that nominal isobars (e.g., H versus N versus C enrichments) can be distinguished from one another, and so molecules do not need to be converted into a homogeneous substrate to facilitate isotope analysis. Like other isotope measurements, measurements of site-specific enrichments on the Orbitrap should be compared to a standard of known composition.