Karunadasa began her independent career at Stanford University in 2012. Her group synthesizes hybrid perovskite materials that combine small organic molecules with inorganic solids. Three-dimensional lead iodide perovskites are being investigated for solar cells, but they can be both unstable and toxic. For example, their sensitivity to water makes them difficult materials to use in the fabrication of large-scale devices. Karunadasa is interested in ways to mitigate these shortcomings, and any transient changes that may occur when these materials absorb light. In particular, Karunadasa has created two-dimensional perovskites, with thin inorganic sheets, that can be tuned to emit every colour of visible light. In these systems the organic small molecules are sandwiched between the sheets. In the case of thick inorganic sheets, the inorganic materials act as absorbers, and enhance the stability of the perovskite materials. The organo-metal-halide perovskites created by Karunadasa and her collaborator Michael D. McGehee can be processed in solution. She believes that through careful chemical design it is possible to determine the fate of photogenerated charge carriers. Karunadasa has investigated the lifetimes of acoustic phonons in lead iodide perovskites with Michael Toney and Aron Walsh.