In 1799, Benjamin Thompson (Count Rumford) had proposed the establishment in London of an Institution for Diffusing Knowledge, i.e. the Royal Institution. The house in Albemarle Street was bought in April 1799. Rumford became secretary to the institution, and Dr Thomas Garnett was the first lecturer.
In February 1801 Davy was interviewed by the committee of the Royal Institution, comprising Joseph Banks, Benjamin Thompson and Henry Cavendish. Davy wrote to Davies Giddy on 8 March 1801 about the offers made by Banks and Thompson, a possible move to London and the promise of funding for his work in galvanism. He also mentioned that he might not be collaborating further with Beddoes on therapeutic gases. The next day Davy left Bristol to take up his new post at the Royal Institution, it having been resolved that Humphry Davy be engaged in the service of the Royal Institution in the capacity of assistant lecturer in chemistry, director of the chemical laboratory, and assistant editor of the journals of the institution, and that he be allowed to occupy a room in the house, and be furnished with coals and candles, and that he be paid a salary of 100l. per annum.
On 25 April 1801, Davy gave his first lecture on the relatively new subject of Galvanism. He and his friend Coleridge had had many conversations about the nature of human knowledge and progress, and Davy's lectures gave his audience a vision of human civilisation brought forward by scientific discovery. "It [science] has bestowed on him powers which may almost be called creative; which have enabled him to modify and change the beings surrounding him, and by his experiments to interrogate nature with power, not simply as a scholar, passive and seeking only to understand her operations, but rather as a master, active with his own instruments." The first lecture garnered rave reviews, and by the June lecture Davy wrote to John King that his last lecture had attendance of nearly 500 people. "There was Respiration, Nitrous Oxide, and unbounded Applause. Amen!" Davy revelled in his public status.