Some reports have been published on the pharmacokinetics of CoQ. The plasma peak can be observed 6-8 hours after oral administration when taken as a pharmacological substance. In some studies, a second plasma peak also was observed at approximately 24 hours after administration, probably due to both enterohepatic recycling and redistribution from the liver to circulation.
Deuterium-labeled crystalline CoQ was used to investigate pharmacokinetics in humans to determine an elimination half-time of 33 hours.