Triptans are specific and selective agonists for the 5-HT receptors. Sumatriptan binds to 5-HT receptors, zolmitriptan, rizatriptan, naratriptan, almotriptan, and frovatriptan binds to 5-HT and eletriptan binds to 5-HT receptors. Triptans are believed to exert their effects through vasoconstriction, leading to reduced carotid arterial circulation without affecting cerebral blood flow, peripheral neuronal inhibition, or inhibition of transmission through second order neurons of the trigeminocervical complex.