In the Late Bronze Age, the site became an administrative center of a larger region in the kingdom of Isuwa. The city was heavily fortified, probably due to the Hittite threat from the west. It was culturally influenced by the Hurrians, Mitanni and the Hittites.
Around 1350 BC, Šuppiluliuma I of the Hittites conquered Melid in his war against Tushratta of Mitanni. At the time Melid was a regional capital of Isuwa at the frontier between the Hittites and the Mitanni; it was loyal to Tushratta. Suppiluliuma I used Melid as a base for his military campaign to sack the Mitanni capital Washukanni.