*Paul Alivisatos (Ph.D. 1986) - Professor Emeritus,  National Medal of Science (2015); Priestley Medal (2020)
*Neil Bartlett - Professor (1969)
*Carolyn Bertozzi (Ph.D. 1993) - Professor (1996-2015), Nobel Prize (2022)
*Melvin Calvin (B.S. 1931, Ph.D. 1935) - Professor, Nobel laureate (1961)
*Robert E. Connick (Ph.D. 1942) - Professor Emeritus of Chemistry, Dean
*Jennifer Doudna - Professor, Wolf Award (2020), Nobel laureate (2020)
*William F. Giauque (B.S. 1920, Ph.D. 1922) - Professor, Nobel laureate (1949)
*John F. Hartwig - Professor, Wolf Award (2019)
*Martin Head-Gordon (B.S. 1983, Ph.D. 1989) - Professor (1992), Medal of the International Academy of Quantum Molecular Sciences (1998)
*Dudley R. Herschbach - Assistant Professor, Nobel laureate (1986)
*Joel Henry Hildebrand (Ph.D. 1906) - Dean (1949–1951), Chairman of the Dept. of Chemistry (1941–1943), Professor
*Darleane Hoffman - Professor, National Medal of Science (1997)
*Judith Klinman - Professor, National Medal of Science (2012)
*Yuan T. Lee (Ph.D. 1965) - Professor, Nobel laureate (1986)
*Gilbert Newton Lewis - Dean (1912–1941), Professor
*Willard F. Libby (B.S. 1931, Ph.D. 1933) - Professor (1933-1941), Nobel laureate (1960)
*Jeffrey R. Long - Professor, National Science Foundation Special Creativity Award
*David MacMillan - Professor (1998-2000), Nobel Prize (2021)
*George C. Pimentel (Ph.D. 1949) - Professor (1949-1989), National Medal of Science (1985)
*Kenneth Pitzer (Ph.D. 1937) - Dean (1951–60), Professor, President of Rice University and Stanford University
*John Prausnitz - Professor, National Medal of Science (2003)
*Glenn T. Seaborg (Ph.D. 1937) - Professor, Nobel laureate (1951)
*Gabor Somorjai - Professor, National Medal of Science (2002)
*Andrew Streitwieser - Professor, National Academy of Science
*Peidong Yang - Professor, MacArthur Genius Award (2015)
*Omar Yaghi - Professor, Wolf Award (2018)