For the measurement of the diversity of fragmentomic features, the PFE metric, derived from Shannons Index of entropy, is developed. The default number of 201 bins of lengths 100 to 300 are used for density estimation by the maximum likelihood method. The probability of having a fragment with size , () is computed by the division of the number of fragments with size  by the total number of fragments. Shannons entropy is calculated with fthe formula: .