Whereas traditional bioinformatics is a wide subject it has a large focus on molecular biology, pharmaceutical bioinformatics more specifically targets chemical-biological interaction and exploratory focus of chemical and biological interactors using e.g. cheminformatics and chemometrics methods. Methods include, apart from many general bioinformatics methods, ligand-based modeling such as Quantitative structure–activity relationship (QSAR) and proteochemometrics, computer-aided molecular design, chembioinformatics databases, algorithms for chemical software, and biopharmaceutical chemistry including analyses of biological activity and other issues related to drug discovery.