Many elegant structural mimics have been synthesized reproducing the atomic content and connectivity of the active site.  The work by Pickett is a prime example of this field.  The catalytic activity of these mimics do not however compare to the native enzyme.  In contrast, functional mimics, also known as bio-inspired catalysts, aim to reproduce only the functional features of an enzyme often through the use of different atomic content and connectivity from that found in the native enzymes.  Functional mimics have made advances in the reactive chemistry and have implications on the mechanistic activity of the enzyme as well as acting as catalysts in their own right.