The following genes are analogous or homologous between Drosophila melanogaster (in bold) and human TNFR1 signalling:
* Imd: human orthologue = RIP1
* Tak1: human orthologue = Tak1
* TAB2: human orthologue = TAB2
* Dredd: human orthologue = caspase-8
* FADD: human orthologue = FADD
* Key/Ikkγ: human orthologue = NEMO
* Ird5: human orthologue = IKK2
* Relish: human orthologues = p65/p50 and IκB
* Iap2: human orthologue = cIAP2
* UEV1a: human orthologue = UEV1a
* bend: human orthologue = UBC13