In a recent publication, REMS technology has received the attention of the European Society for Clinical and Economic Aspects of Osteoporosis, Osteoarthritis and Musculoskeletal Diseases  ([http://www.esceo.org/ ESCEO]). In this work, all the available technologies for bone strength assessment and fracture risk estimation have been reviewed and discussed in relation to the clinical needs currently unmet. In this context, REMS has been considered a valuable approach for osteoporosis diagnosis and for fracture risk assessment, at the same time overcoming several of the current limitations acknowledged for the currently available bone health assessment technologies. One example is the work of Degennaro et al. in which a significant BMD reduction has been detected in pregnant women compared to non-pregnant women for the very first time. Several international working groups has used REMS technology for research purposes: Bojincă et al. has proven the effectiveness of REMS BMD estimates in patients affected by rheumatoid arthritis. Kirilova et al. assessed the values of lumbar spine and hip REMS-based BMD in premenopausal and postmenopausal women. In Khu et al. REMS has been used for characterizing the relationship between body mass index and bone health. The growing interest towards REMS is also demonstrated by the publication of scientific review papers focused on this technology.