In the United States, the Clean Water Act requires all direct effluent discharges to surface waters to be regulated with permits under the National Pollutant Discharge Elimination System (NPDES). Indirect dischargers–facilities which send their wastewater to municipal sewage treatment plants–may be subject to pretreatment requirements. NPDES permits require discharging facilities to limit or treat effluent to the levels that result from using the most effective treatment technologies possible at a practical cost to mitigate the effects of discharges on the receiving waters. EPA has published technology-based regulations, called "effluent guidelines", for 59 industrial categories. The agency reviews the standards annually, conducts research on various categories, and makes revisions as appropriate. Noncompliance with these standards and all other conditions in the permits is punishable by law. Each year, effluent guidelines regulations prevent billions of pounds of contaminants from being released into bodies of water.
EPA regulations require effluent limitations to be expressed as mass-based limits (rather than concentration-based limits) in the permits, so that discharging facilities will not use dilution as a substitute for treatment. In cases where setting mass-based limits are infeasible, the permit authority must set conditions in the permit that prohibit dilution.