C-Path programs are focused on reducing the time, cost, and risk of drug development and regulatory review. Where appropriate, C-Path forms consortia to improve the drug development process.
* The Predictive Safety Testing Consortium (PSTC) works to find improved safety biomarkers to detect drug induced toxicity.
* The Patient-Reported Outcome (PRO) Consortium develops, evaluates, and qualifies PRO instruments (e.g., questionnaires) for use in clinical trials designed to assess the safety and effectiveness of medical products.
* The Critical Path to TB Drug Regimens (CPTR) aims to accelerate the development of new, safe, and highly effective tuberculosis treatment regimens with shortened durations of therapy.
*The Polycystic Kidney Disease (PKD) Consortium evaluates the evidence supporting total kidney volume (TKV) as a biomarker for assessing the progression of autosomal dominant PKD.
*The Critical Path for Alzheimer's Disease (CPAD) aims to increase the efficiency of the development process of new treatments for Alzheimer disease (AD) and related neurodegenerative disorders with impaired cognition and function.
*The Critical Path for Parkinson's (CPP) works to improve the clinical trial process.
*The Data Collaboration Center (DCC) develops data solutions for scientific research.
*The Duchenne Regulatory Science Consortium (D-RSC) supports collaborative research through shared data access and drug development tools.
*The Electronic Patient-Reported Outcome Consortium (e-PRO) supports the collection of patient-focused outcomes data in clinical trials.
*The Huntingtons Disease Regulatory Science Consortium (HD-RSC) aims to accelerate the regulatory approval of Huntingtons disease therapies.
*The International Neonatal Consortium (INC) seeks to forge a predictable regulatory path for evaluating the safety and effectiveness of therapies for neonates.
*The Multiple Sclerosis Outcome Assessments Consortium (MSOAC) works to qualify a new measure of disability as a primary or secondary endpoint for future trials of MS therapies.
*The Type 1 Diabetes Consortium (T1D) works to qualify islet autoimmunity antibodies as prognostic biomarkers.
*The goal of the Transplant Therapeutics Consortium (TTC) is to accelerate the medical product development process for transplantation.
*The TB-Platform for Aggregation of Clinical TB Studies (TB-PACTS) curates and standardizes Phase III tuberculosis (TB) clinical trial data.
*The successfully completed Pediatric Trials Consortium worked toward the efficient evaluation of innovative drugs, biologics, and devices for children.