* Full-length ncRNA capture – BoMoC has high processivity across modified RNA templates resulting in the production of more full-length cDNA products compared to common reverse transcriptase's, which are prone to premature termination at modified sites.
* Single tube reaction – All cDNA synthesis steps can be performed in a single tube, without the need for intermediate purification steps. This allows for automation of the OTTR approach. Additionally, this reduces the total amount of input RNA required purification steps, prone to loss of 
* Capture of modified sites – Mis-incorporation signatures of BoMoC across modified RNA bases have been characterized. Therefore, OTTR allows for the identification of modification status of RNA transcripts where modified sites are known.
* Sequencing of both RNA and DNA templates – While RNA templates have been used to benchmark the OTTR technique, BoMoC is processive over DNA, meaning this library preparation approach could be adapted for DNA characterization.