The ENCyclOpedia of Rna Epitranscriptome (ENCORE) is an upgraded version of [https://rna.sysu.edu.cn/encore/index.php RMBase] that a comprehensive epitranscriptome platform with tens of new software and tools, to decode the distribution pattern, metagene profile, biogenesis mechanisms, regulatory functions, interactome, evolutional conservation and novel reader proteins of more than 70 different types of RNA modifications by analyzing thousands of high-throughput sequencing data.