Inverse agonists differ from regular agonists in that they effect receptors to which a regular agonist binds such that the bound receptors demonstrate reduced activity compared to when they are normally inactive. In other words, inverse antagonists limit the efficacy of the bound receptor in some way. This is noted to be beneficial in instances wherein expression of receptors or up-regulated receptor sensitivity could be detrimental, thus making suppression of response the best recourse. A handful of examples of inverse agonist use in therapy include β-blockers, antihistamines, ACP-103 to treat Parkinson's disease, hemopressin, drugs to treat obesity, and more besides.