The C–H···O interaction was discovered in 1937 by Samuel Glasstone. Glasstone studied properties of mixtures of acetone with different halogenated derivatives of hydrocarbons and realized that dipole moments of these mixtures differ from dipole moments of pure substances. He explained this by establishing the concept of C–H···O interactions. The first crystallographic analysis of C-H ⋯O hydrogen bonds were published by June Sutor in 1962.