The Jameson Cell reportedly has the following advantages:
* relatively low energy use – the only energy that is required to operate the Cell is to pump the slurry through the slurry lens. This means that it requires significantly less electricity than conventional mechanical or column flotation cells. In addition, the better particle–bubble contact means that fewer Cells are required for the equivalent duty of mechanical cells, giving an even bigger power saving. 
* high recovery of fines – The Cell is able to achieve final product specification from previously discarded coal fines at very high recoveries (95–98%) in a single pass. It has also been shown to be effective in recovering fine particles in base metals, potash and phosphate applications.
* effective froth washing – The Cell uses froth washing as standard to control concentrate grade. A conventional flotation cell has problems with recovering fine particles at high grades due to the entrainment of gangue minerals in the froth. The high throughput of the Jameson Cell means that the froth is produced in a small surface area so it is economic to apply froth washing to all cells
* easily scaled up – the hydrodynamic conditions for particle collection inside the downcomer and separation in the tank are identical between the laboratory, pilot plant and industrial-scale Jameson Cell, meaning that there is direct scale-up. This makes predicting plant performance for small-scale tests straightforward. In contrast, factors have to be used to scale-up the design of mechanical and column flotation cells.
* relatively small footprint – the high intensity of bubble-particle contact means that very low residence times are required in the Cell (residence time in the downcomer is 5–10 seconds and the separation tank volume is small compared with alternative technologies). This means that the total volume of the Cell is lower than the alternatives.
* fast response to process changes – process variables such as air flow rate, froth depth and wash water are all automated making optimisation straightforward. The small tank volumes means very short residence times in the tank (typically 1–3 minutes) so changes made, whether they are deliberate or from normal plant fluctuations, are observed almost instantly. 
* rapid start-up and shutdown – the small volume of the tank means that the Cell can be filled and drained quickly so with plant upsets the Cell can reach steady state very quickly. 
* low maintenance costs – the  Cell has no moving parts and is designed to provide easy access to serviceable parts. The slurry lens orifice has a service life exceeding 5 years under normal operating conditions and the service life of the other wet-end wear parts is reported to be over 10 years under normal operating conditions.
* low capital cost – the small footprint of the Cell reduces the amount of steel required in its construction and, coupled with the simplicity of its design, has lower installation costs when compared with conventional or column flotation cells. 
* low operating costs – the lack of moving parts with a consequent lower power consumption, long wear life and easy access results in low operating costs.
* short payback periods – Cell users typically report short payback periods for their investments in the technology. For example, the 2007 installation of a 5.4 m diameter Jameson Cell with 18 downcomers to treat preflotation concentrate recovered up to 90% of the zinc previously lost to the tailings disposal facility and had a payback of approximately one year at the zinc prices of the day. Peko Mines reported a payback period of two months for its Cell installation. The complete replacement of 32 mechanical cells with eight Jameson Cells at the Goonyella coal mine had a payback of 17 months. More recently, the installation of a Cell ahead of each of two cleaner trains at the Telfer Mine had a payback of between two and seven months.