Novec 649 is a low-temperature heat-transfer fluid. It has been used as a full-immersion fluid in a proof of concept data center cooling system by Intel and SGI. As it boils off easily due to its  boiling point, it is used in two-phase immersion cooling system with a condensing loop running cold water. Effects of evaporative cooling was utilized to remove additional heat. Novec 649 is also being considered to be used for cooling silicon photomultiplier (SiPM) sensors to  in single-phase configuration as part of Large Hadron Collider’s high luminosity upgrade. 
Traditional perfluorocarbon (PFC) based compounds used for cooling, such as Fluorinert, display high global warming potentials (GWPs), typically 5,000 to 10,000 times that of CO. Novec 649 was chosen as a good drop-in replacement due to it having similar thermo-physical properties to Fluorinert FC-72 (perfluorohexane, C6F14) while exhibiting a very low global warming potential of 1.