Exposure to MAM before birth increases susceptibility to epileptic seizures caused by flurothyl. Prenatal MAM exposure in rats results in a model of brain malformation.  In some MAM animals, video-EEG monitoring has documented the presence of spontaneous electrographic seizure activity  In some epilepsy rat models, MAM is administered at the fifteenth gestational day. Previous studies have found impaired cognitive function in GD15 MAM rats, and a reduced seizure threshold.  At the cellular level, dysplastic hippocampal neurons in the MAM model were shown to have reduced potassium current function and expression for the Kv4.2 channel subunit   These findings may contribute to the spontaneous seizures and reduced seizure thresholds seen in this model.