The MEDICIS facility is located in the extension of building 179 at the CERN Meyrin site, next to the ISOLDE building. The facility was established by CERN in 2010, along with contributions from the CERN Knowledge Transfer Fund, as well as receiving a European Commission Marie-Skłodowska-Curie training grant under the title MEDICIS-PROMED. The construction of the facility started in September 2013 and was completed in 2017.
ISOLDE directs a 1.4 GeV proton beam from the Proton Synchrotron Booster (PSB) onto a thick target, the material dependent on the desired produced isotopes. Only 10% of the proton beam used in the ISOLDE facility is absorbed by the target, with the rest otherwise hitting the beam dump. MEDICIS uses these wasted protons to irradiate a second target, which produces specific isotopes, placed behind each of ISOLDE's target stations, the High Resolution Separator (HRS) and the General Purpose Separator (GPS). Alternatively, the facility uses pre-irradiated targets that are provided by external institutions. MEDICIS was one of the few facilities operating throughout the Long Shutdown 2, due to it being provided with 34 externally irradiated target materials.
Due to the high levels of radiation, the targets are transferred from the irradiation station to the radioisotope mass-separation beamline using an automated rail conveyer system (RCS). A KUKA robot is used to transport the target to the station, where the isotope of interest can be collected and radiochemically purified. This is done by heating the target up to very high temperatures, often more than 2000 °C, which causes the specified isotopes to diffuse. The isotopes are then ionised and accelerated by an ion source to be sent through a mass separator. The mass separator extracts the isotope of interest so that it can be implanted onto thin gold foils with a one-sided metallic or salt coating. 
In 2019, the MEDICIS Laser Ion Source Setup At CERN (MELISSA) became fully operational, containing the individual lasers, auxiliary and control systems, and optical beam transport. The MELISSA laser laboratory has helped to successfully increase the separation efficiency and the yield of the isotopes. The laser excites only isotopes of the desired element, allowing an element-selective isotope separation for a given atomic mass from other isobars by the mass separator.
A shielded trolley is used to retrieve the samples after the radioisotopes have been collected, in order to avoid risk of contamination. Once the target is finished being used, it is sent to a hot cell in order to be safely dismantled and put in waste bins. Once collected, the samples can be sent to hospitals and research facilities with the purpose of developing patient imaging and treatment, and therapy protocols.
Additionally next to the MEDICIS facility, there is a nanolab laboratory designed for the development and assembly of nanomaterials. The nanomaterials are sealed in a glovebox, meaning there is no contact with the outside environment. It builds up on the development of the first nanostructured targets used for isotope production, and further exploits developments initiated in MEDICIS-Promed under the guidance of Prof. "Kostya" Novozelov.