Hexosaminidases (Hex) are important glycoside hydrolases for the generation of plant-specific paucimannosidic proteins across Plantae. HEXO1-HEXO3 have been reported to be key mediators of paucimannose expression in various plant species including Nicotiana benthamiana, A.thaliana and L. japonicus. Moreover, α1,3-fucosyltransferase (FUT11/12) and β1,2-xylosyltransferase as well as α-mannosidase II were also reported to play critical roles in the generation of the paucimannosidic proteins expressed by plants.