In the 1970s and 1980s improved application technologies such as controlled droplet application (CDA) received extensive research interest, but commercial uptake has been disappointing. By controlling droplet size, ultra-low volume (ULV) or very low volume (VLV) application rates of pesticidal mixtures can achieve similar (or sometimes better) biological results by improved timing and dose-transfer to the biological target (i.e. pest). No atomizer has been developed able to produce uniform (monodisperse) droplets, but rotary (spinning disc and cage) atomizers usually produce a more uniform droplet size spectrum than conventional hydraulic nozzles (see: [http://www.dropdata.org/DD/sprayers.htm#CDA CDA & ULV application equipment]). Other efficient application techniques include: banding, baiting, specific granule placement, seed treatments and weed wiping.
CDA is a good example of a rational pesticide use (RPU) technology (Bateman, 2003), but unfortunately has been unfashionable with public funding bodies since the early 1990s, with many believing that all pesticide development should be the responsibility of pesticide manufacturers. On the other hand, pesticide companies are unlikely widely to promote better targeting and thus reduced pesticide sales, unless they can benefit by adding value to products in some other way. RPU contrasts dramatically with the promotion of pesticides, and many agrochemical concerns, have equally become aware that product stewardship provides better long-term profitability than high pressure salesmanship of a dwindling number of new “silver bullet” molecules. RPU may therefore provide an appropriate framework for collaboration between many of the stake-holders in crop protection.
Understanding the biology and life cycle of the pest is also an important factor in determining droplet size. The Agricultural Research Service, for example, has conducted tests to determine the ideal droplet size of a pesticide used to combat corn earworms. They found that in order to be effective, the pesticide needs to penetrate through the corns silk, where the earworms larvae hatch. The research concluded that larger pesticide droplets best penetrated the targeted corn silk.  Knowing where the pest's destruction originates is crucial in targeting the amount of pesticide needed.