Dicloxacillin is used to treat mild-to-moderate staphylococcal infections. To decrease the development of resistance, dicloxacillin is recommended to treat infections that are suspected or proven to be caused by beta-lactamase-producing bacteria.
Dicloxacillin is similar in pharmacokinetics, antibacterial activity, and indications to flucloxacillin, and the two agents are considered interchangeable. It is believed to have lower incidence of severe hepatic adverse effects than flucloxacillin, but a higher incidence of renal adverse effects.
Dicloxacillin is used for the treatment of infections caused by susceptible bacteria. Specific approved indications include: 
*Staphylococcal skin infections and cellulitis – including impetigo, otitis externa, folliculitis, boils, carbuncles, and mastitis
*Pneumonia (adjunct)
*Osteomyelitis, septic arthritis, throat infections, streptococcus
*Septicaemia
*Empirical treatment for endocarditis
*Surgical prophylaxis