Cannabinoid CP55,940 and △-tetrahydrocannabinol (△-THC) can induce the release of dynorphin B, which in return acts as an agonist of κ-opioid receptors, resulting in the production of antinociception. Similarly, Tyr-D-Arg-Phe-Sar (TAPS) is capable of promoting a release of dynorphin B through the simulation of μ-opioid receptors, causing a production of antinociception. The antinociceptive effect produced by dynorphin B allows for spinal analgesia.