Nesfatin-1 is a polypeptide encoded in the N-terminal region of the protein precursor, Nucleobindin-2 (NUCB2).
Recombinant human Nesfatin-1 is a 9.7 kDa protein containing 82 amino acid residues. Nesfatin-1 is expressed in the hypothalamus, in other areas of the brain, and in pancreatic islets, gastric endocrine cells and adipocytes.