Selenols are important in certain biological processes. Three enzymes found in mammals contain selenols at their active sites: glutathione peroxidase, iodothyronine deiodinase, and thioredoxin reductase. The selenols in these proteins are part of the essential amino acid selenocysteine. The selenols function as reducing agents to give selenenic acid derivative (), which in turn are re-reduced by thiol-containing enzymes.  Methaneselenol (commonly named "methylselenol") (), which can be produced in vitro by incubating selenomethionine with a bacterial methionine gamma-lyase (METase) enzyme, by biological methylation of selenide ion or in vivo by reduction of methaneseleninic acid (), has been invoked to explain the anticancer activity of certain organoselenium compounds. Precursors of methaneselenol are under active investigation in cancer prevention and therapy. In these studies, methaneselenol is found to be more biologically active than ethaneselenol () or 2-propaneselenol ().