NanoProfessionals have alternate molecular structures for the top of the head, and possibly include a hat. Most can be synthesized from the NanoKid by an acetal exchange reaction with the desired 1,2- or 1,3- diol, using p-toluenesulfonic acid as catalyst and heated by microwave irradiation for a few minutes. The ultimate set of products was a recognizably diverse population of NanoPutians: NanoAthlete, NanoPilgrim, NanoGreenBeret, NanoJester, NanoMonarch, NanoTexan, NanoScholar, NanoBaker, and NanoChef.
The majority of the figures are easily recognizable in their most stable conformation. A few have as their stable conformation a less recognizable shape, so these are often drawn in the more recognizable but less stable way. Many liberties were taken in the visual depiction of the head dressings of the NanoPutians. Some products are formed as a mixture of diastereomers—the configuration of the "neck" compared to parts of the "hat".