When the tissues release carbon dioxide into the bloodstream, around 10% is dissolved into the plasma. The rest of the carbon dioxide is carried either directly or indirectly by hemoglobin. Approximately 10% of the carbon dioxide carried by hemoglobin is in the form of carbaminohemoglobin. This carbaminohemoglobin is formed by the reaction between carbon dioxide and an amino (-NH) residue from the globin molecule, resulting in the formation of a carbamino residue (-NH.COO). The rest of the carbon dioxide is transported in the plasma as bicarbonate anions.