In science fiction, mutagens are often represented as substances that are capable of completely changing the form of the recipient or granting them superpowers. Powerful radiations are the agents of mutation for the superheroes in Marvel Comicss Fantastic Four, Daredevil, and Hulk, while in the Teenage Mutant Ninja Turtles franchise the mutagen is a chemical agent also called "ooze", and for Inhumans the mutagen is the Terrigen Mist. Mutagens are also featured in video games such as Cyberia, System Shock, The Witcher, Metroid Prime: Trilogy, Resistance: Fall of Man, Resident Evil, Infamous,  Freedom Force, Command & Conquer, Gears of War 3, StarCraft, BioShock, Fallout, Underrail, and Maneater'.
In the "nuclear monster" films of the 1950s, nuclear radiation mutates humans and common insects often to enormous size and aggression; these films include Godzilla, Them!, Attack of the 50 Foot Woman, Tarantula!, and The Amazing Colossal Man.