Sala married three times; first to Maria Ennan, who gave birth to a sole child, daughter Maria, who on 5 January 1608 was baptized in Winterthur. She later married the Oldenburg physician Anton Günther Billich, who was friends with Sala. However they divorced in 1634, Sala's granddaughter Marie Sophie was never recognized by Billich.
Sala married a second time in the German Reformed Community in Hamburg on the 15 April 1621, to Cornelia de L'Hommels.
His third marriage was with Katharina von Brockdorff (born 1608) in Lübeck in 1628. Their descendants were confirmed in the Reich through the nobility in which the Sala family had been established in Italy. Sala's great-grandson Gerd Carl Graf von Sala even achieved entry to the imperial count in 1751. However, the German Sala branch died out with his son Hans Christian in 1806.
Sala died on the 2nd. October 1637 at the age of 61 in Bützow, after having cut himself three days earlier. He was buried on 20 October in the Cathedral of St. Maria, St. Johannes Evangelista and St. Cäcilia.