To study charge transfer reactions of an ITIES, a four-electrode cell is used.
Two reference electrodes are used to control the polarisation of the interface, and two counter electrodes made of noble metals are used to pass the current. The aqueous supporting electrolyte must be hydrophilic, such as LiCl, and the organic electrolyte must be lipophilic, such as tetraheptylammonium tetra-pentafluorophenyl borate.