*PLC-ε (230-260kDa ) is activated by Ras and Rho GTPases.
*PLC-ζ (75kDa) is thought to play an important role in vertebrate fertilization by producing intracellular calcium oscillations important for the start of embryonic development. However, the mechanism of activation still remains unclear. This isoform is also capable of entering the early-formed pronucleus after fertilization, which seems to coincide with the cessation of calcium mobilization. It, like PLC-δ1 and PLC-β, possesses nuclear export and localization sequences.
*PLC-η has been implicated in neuronal functioning.