Huntingtons disease is characterized by cognitive impairments. There is increased expression of p75NTR in the hippocampus of Huntingtons disease patients (including mice models and humans). Over expression of p75NTR in mice causes cognitive impairments similar to Huntingtons disease.  p75NTR is linked to reduced numbers of dendritic spines in the hippocampus, likely through p75NTR interactions with Transforming protein RhoA. Modulating p75NTR function could be a future direction in treating Huntingtons disease.