The dynamic reciprocity theory states that a cell’s fate depends on the exchange of chemical signals between the extracellular matrix and the nucleus of the cell. Focussing on connections between laminin-111 and other proteins involved in cell-to-cell communication could spark further research that may help to further our current understanding of cancer and how to slow down or stop its process.
Actin plays a role in nuclear activity which is an important process with regard to cell signalling influencing cell differentiation and replication. It has been suggested that actin interactions directly influence gene transcription as it interacts with chromatin remodeling complexes as well as RNA polymerases I, II and III. However, the exact role that actin plays in transcription has not yet been determined.