Amyloid precursor protein has been shown to interact with:
* APBA1,
* APBA2,
* APBA3,
* APBB1,
* APPBP1,
* APPBP2,
* BCAP31,
* BLMH
* CLSTN1,
* CAV1,
* COL25A1,
* FBLN1,
* GSN,
* HSD17B10, and
* SHC1.
APP interacts with reelin, a protein implicated in a number of brain disorders, including Alzheimer's disease.