In their 2010 Synlett article, Martina Wernerova and organic chemist, Tomáš Hudlický, raised concerns about inaccurate reporting of yields, and offered solutions—including the proper characterization of compounds. After performing careful control experiments, Wernerova and Hudlický said that each physical manipulation (including extraction/washing, drying over desiccant, filtration, and column chromatography) results in a loss of yield of about 2%.  Thus, isolated yields measured after standard aqueous workup and chromatographic purification should seldom exceed 94%. They called this  phenomenon  "yield inflation" and said that yield inflation had gradually crept upward in recent decades in chemistry literature.  They attributed yield inflation to careless measurement of yield on reactions conducted on small scale, wishful thinking and a desire to report higher numbers for publication purposes. Hudlickýs 2020 article published in Angewandte Chemie—since retracted—honored and echoed Dieter Seebachs often-cited 1990 thirty-year review of organic synthesis, which had also been published in Angewandte Chemie. In his 2020  Angewandte Chemie 30-year review, Hudlický  said that the suggestions that he and Wernerova had made in their 2010 Synlett article, were "ignored by the editorial boards of organic journals, and by most referees."