Mississippi basin
* The Greater Twin Cities area of Minneapolis and St. Paul, Minnesota features two important Mississippi confluences. Near historical Fort Snelling and the town of Mendota—about 9 miles downstream on the Mississippi from Minneapolis—the Minnesota River flows into the Mississippi at Pike Island. The area around this confluence is a location of spiritual, cultural, and historical significance to the Dakota people and is also the site of the earliest European settlements in the Twin Cities area. About 30 miles further downstream from the Minnesota-Mississippi confluence—and 25 miles downstream from St. Paul—the Mississippi joins with the St. Croix River near Hastings, Minnesota, and Prescott, Wisconsin.   
* Vicksburg, Mississippi lies atop bluffs overlooking the confluence of the Mississippi River with its tributary the Yazoo. Both rivers, as well as the bluffs, played an important role in the Vicksburg Campaign, a pivotal event of the American Civil War.
* The Missouri River flows into the Mississippi River at Jones-Confluence Point State Park, just north of St. Louis, Missouri. Slightly further upstream, the Illinois River flows into the Mississippi.
* The Madison, Jefferson and Gallatin Rivers in Three Forks, Montana form the confluence of the Missouri River.
* At Keokuk, Iowa, the Des Moines River flows into the Mississippi. This forms the political tripoint between the U.S. states of Iowa, Missouri, and Illinois.
* Just south of Cairo, Illinois, the Ohio River flows into the Mississippi, forming the tripoint between the states of Illinois, Missouri, and Kentucky.
* The Ohio River is formed by the confluence of the Monongahela and Allegheny rivers, located in Pittsburgh, Pennsylvania. The site is of great historical significance; in the 1970s it was upgraded by the creation of Point State Park, highlighted by a large fountain.
Atlantic watersheds
* At Harpers Ferry, West Virginia, the Shenandoah River flows into the Potomac River, at the tripoint of the U.S. states of Virginia, West Virginia, and Maryland.
* At Philadelphia, Pennsylvania, the Schuylkill River flows into the Delaware River, next to the former Philadelphia Naval Shipyard; the site remains industrial.
* At Cohoes, New York, a few miles north of Albany, the Mohawk River flows into the Hudson in three channels separated by islands. The confluence is historically important: upstream traffic on or along the Hudson often took a left turn at the Mohawk, which offers a uniquely level passageway through the Appalachian Mountains that assisted commerce and the settlement of the West.
* At Ottawa, the capital of Canada, the Rideau River flows—unusually, as a waterfall—into the Ottawa River; see Rideau Falls. On the island separating the two portions of the falls is a park with military monuments, among them the Ottawa Memorial.
* The Hochelaga Archipelago, including the island and city of Montreal, is located where the Ottawa River flows into the St. Lawrence River in Quebec, Canada.
* Winnipeg, Canada, is at the confluence of the Red River, and the Assiniboine River.  The area is referred to as The Forks by locals, and has been an important trade location for over 6000 years.
Pacific watersheds
* The Green River flows into the Colorado River at the heart of Canyonlands National Park in Utah's Canyon Country.
* The Snake River flows into the Columbia River at Sacagawea State park near the Tri-Cities of Washington. It should also be noted that the significant Yakima river also flows into the Columbia just a few miles upstream, thus giving the region the unofficial preposition of Three Rivers
* In Portland, Oregon, the Willamette River flows into the Columbia at Kelley Point Park, built on land acquired from the Port of Portland in 1984.
* Lytton, British Columbia, Canada, is located at the confluence of the muddy Fraser River and the clearer Thompson River.