* Advantages
** At large, protocells are advantageous because they can store more drugs, be loaded faster than other nanomedicine delivery systems, and are more stable than liposomes. By keeping more drugs, researchers can reduce the quantity of medications needed to be administered, potentially reducing side effects and toxicity. In like manner, controlling the direction and movement of a drug also reduces the amount of medication needed, increases the speed of delivery, and allows for the controlled release of high-concentration multicomponent cargo within cancer cells. Finally, the stability of protocells is vital because it ensures that the drugs remain effective and do not degrade before reaching their target. Overall, the development of protocells as a drug delivery system, coupled with chemotactic properties, holds great promise for targeted drug delivery. 
* Limitations
** One fundamental limitation of protocells is their modularity and versatility, which must be accounted for when assessing clinical applications. Modularity and versatility are essential considerations for targeted drug delivery because they enable the customization and adaptation of drug delivery systems to meet specific clinical needs. In fact, without modularity and versatility, it will be hard to tailor protocells to different therapeutic applications and particular populations. Another critical challenge, especially when using enzymes to maneuver the protocell, is that the motility reduces when the enzymes become oversaturated with the chemical stimuli. Reducing motility becomes a problem because this is essential for targeted drug delivery efficiency, limiting the system's effectiveness and increasing the risk of off-target effects. Therefore, further research is still needed to improve our understanding of protocells and their potential clinical applications.