Current methods to radiofluorinate non-activated aromatic rings are generally limited to esoteric electrophilic [F]F reactions, transition-metal mediated, or iodonium salt based methods. The Vasdev Lab has a long-established history of labeling non-activated aromatics and recently discovered a simple synthetic strategy for incorporating [F]fluoride into non-activated aromatic molecules using spirocyclic iodoium ylide based precursors. Based on their paper in Nature Communications, a patent has been licensed by the pharmaceutical industry to employ this method for the synthesis of radiopharmaceuticals in humans. Hence, the iodonium ylide technology for fluorination represents a major advance for PET imaging.