Lohr and coworkers (2001) report that in a comprehensive study of pancreatic secretions of individuals without pancreatic carcinoma, p53 mutations could be found in the pancreatic juices of a small percentage of participants.  Because mutations of p53 has been extensively found in pancreatic carcinomas, the researchers for this investigation were attempting to determine if the mutation itself can be linked to the development of pancreatic cancer.  While Lohr was able to find p53 mutations via TGGE in a few subjects, none subsequently developed pancreatic carcinoma.  Thus, the researchers conclude by noting that the p53 mutation may not be the sole indicator of pancreatic carcinoma oncogenesis.