Amongst Rgg-like proteins, it has been observed that the pH sensitive histidine (particularly H144) and interacting amino acids (Y176, Y182, and E185) of ropB of Streptococcus pyogenes are conserved in S. porcinus, S. pseudoporcinus, S. salivarius , L. pentosus, Enterococcus sp., L. aviaries, E. faecalis, and L. reuteri. Thus, suggesting the usage of a pH sensitive histidine switch complex with gene regulating effector molecules in a slew of other bacteria [See Also: allosteric regulation].