Because digitized 2D periodic images are in the information theoretical approach just data organized in 2D arrays of pixels, core features of Crystallographic Image Processing can be utilized independent of the type of microscope with which the images/data were recorded. The CIP technique has, accordingly been applied (on the basis of the 2dx program) to atomic resolution Z-contrast images of Si-clathrates, as recorded in an aberration-corrected scanning transmission electron microscope. Images of 2D periodic arrays of flat lying molecules on a substrate as recorded with scanning tunneling microscopes  were also crystallographic processed utilizing the program CRISP.