The Mecke reagent is used as a simple spot-test to presumptively identify alkaloids as well as other compounds. It is composed of a mixture of selenous acid and concentrated sulfuric acid, which is dripped onto the substance being tested.
The United States Department of Justice method for producing the reagent is the addition of 100 mL of concentrated (95–98%) sulfuric acid to 1 g of selenous acid. While sale to the general public is legal, it is not recommended as strong corrosives can cause permanent skin and eye damage and require extensive safety ratings.