The research in his laboratory focuses on cardiovascular and systemic metabolism and particularly on signaling mechanisms that link cardiac stress in diabetes, sepsis and ischemia with altered myocardial fatty acid metabolism. His published work focuses on the transcriptional regulation of proteins that underlie lipoprotein metabolism, cardiac and systemic fatty acid metabolism, and mitochondrial function. His work has identified the role of Krüppel-like factor 5 (KLF5) in the regulation of cardiac fatty acid metabolism in diabetes and ischemic heart failure, as well as how cardiac lipotoxicity leads to cardiac dysfunction, and the importance of cardiac fatty acid oxidation and mitochondrial integrity for the treatment of cardiac dysfunction in sepsis.