*The science fiction novel Mother of Storms by John Barnes offers a fictional example of catastrophic climate change caused by methane clathrate release.
*In The Life Lottery by Ian Irvine unprecedented seismic activity triggers a release of methane hydrate, reversing global cooling.
*The hypothesis is the basis of an experiment in the PlayStation 2 game Death By Degrees.
*In Transcendent by Stephen Baxter, averting such a crisis is a major plotline.
*The novel The Black Silent by author David Dun features this idea as a key scientific point.
*In the anime Ergo Proxy, a string of explosions in the methane hydrate reserves wipes out 85% of species on Earth.
*The novel The Far Shore of Time by Frederik Pohl features an alien race attempting to destroy humanity by bombing the methane clathrate reserves, thus releasing the gas into the atmosphere.
*The novel The Swarm by Frank Schätzing features what first appear to be freak events related to the world's oceans.
*In Charles Stross Laundry Files' universe, an intentionally triggered clathrate gun scenario is viewed as a possible retaliatory strategy that could be utilized by Blue Hades in response to terminal violation of the Benthic Treaty.