An antagonist of a prostaglandin E2 receptor has been shown to serve as an affective contraceptive for female macaques while unaffecting their menstrual cyclicity as well as hormonal patterns. The exact reason behind the reduced amount of successful pregnancies of primates during the study is unclear due a number of possibilities that may affect such result.
Inhibition of the prostaglandin E2 EP receptor has been shown to inhibit tumor growth, angiogenesis, lymphangiogenesis, and metastasis.