The periactive zone surrounds the active zone and is the site of endocytosis of the presynaptic terminal.  In the periactive zone, scaffolding proteins such as intersectin 1 recruit proteins that mediate endocytosis such as dynamin, clathrin and endophilin.  In Drosophila the intersectin homolog, Dap160,  is located in the periactive zone of the neuromuscular junction and mutant Dap160 deplete synaptic vesicles during high frequency stimulation.