The Great Oxygenation Event (GOE) is characterized by the disappearance of sulfur isotope mass-independent fractionation (MIF) in the sedimentary records at around 2.45 billion years ago (Ga).  The MIF of sulfur isotope (ΔS) is defined by the deviation of measured δS value from the δS value inferred from the measured δS value according to the mass dependent fractionation law. The Great Oxidation Event represented a massive transition of global sulfur cycles. Before the Great Oxidation Event, the sulfur cycle was heavily influenced by the ultraviolet (UV) radiation and the associated photochemical reactions, which induced the sulfur isotope mass-independent fractionation (ΔS ≠ 0). The preservation of sulfur isotope mass-independent fractionation signals requires the atmospheric O lower than 10 of present atmospheric level (PAL).  The disappearance of sulfur isotope mass-independent fractionation at ~2.45 Ga indicates that atmospheric pO exceeded 10 present atmospheric level after the Great Oxygenation Event.  Oxygen played an essential role in the global sulfur cycles after the Great Oxygenation Event, such as oxidative weathering of sulfides.  The burial of pyrite in sediments in turn contributes to the accumulation of free O in Earth's surface environment.