The [http://hive.biochemistry.gwu.edu/ High-performance Integrated Virtual Environment] (HIVE) is a distributed computing environment used for healthcare-IT and biological research, including analysis of Next Generation Sequencing (NGS) data, preclinical, clinical and post market data, adverse events, metagenomic data, etc.  Currently it is supported and continuously developed by US Food and Drug Administration (government domain), George Washington University (academic domain), and by DNA-HIVE, WHISE-Global and Embleema (commercial domain). HIVE currently operates fully functionally within the US FDA supporting wide variety (+60) of regulatory research and regulatory review projects as well as for supporting MDEpiNet medical device postmarket registries. Academic deployments of HIVE are used for research activities and publications in NGS analytics, cancer research, microbiome research and in educational programs for students at GWU. Commercial enterprises use HIVE for oncology, microbiology, vaccine manufacturing, gene editing,  healthcare-IT, harmonization of real-world data, in preclinical research and clinical studies.