The sigma-2 receptor takes part in a number of normal-function roles, including cell proliferation, autophagy, cholesterol homeostasis, and both non-neuronal and neuronal signaling. Much of sigma-2 receptor function relies on signaling cascades. The receptor's interaction with EGFR and PGRMC1 proteins allow for sigma-2 receptors to play diverse roles within cell through Ras, PLC, and PI3K signaling.