While the Toll and Imd signalling pathways of Drosophila are commonly depicted as independent for explanatory purposes, the underlying complexity of Imd signalling involves a number of likely mechanisms wherein Imd signalling interacts with other signalling pathways including Toll and JNK. While the paradigm of Toll and Imd as largely independent provides a useful context for the study of immune signalling, the universality of this paradigm as it applies to other insects has been questioned. In Plautia stali stinkbugs, suppression of either Toll or Imd genes simultaneously leads to reduced activity of classic Toll and Imd effectors from both pathways.