Because of the small size of the fluidic conduits, nanofluidic structures are naturally applied in situations demanding that samples be handled in exceedingly small quantities, including Coulter counting, 
analytical separations and determinations of biomolecules, such as proteins and DNA, 
and facile handling of mass-limited samples.  One of the more promising areas of nanofluidics is its potential for integration into microfluidic systems, i.e. micrototal analytical systems or lab-on-a-chip structures.  For instance, NCAMs, when incorporated into microfluidic devices, can reproducibly perform digital switching, allowing transfer of fluid from one microfluidic channel to another, 
selectivity separate and transfer analytes by size and mass, 
mix reactants efficiently, 
and separate fluids with disparate characteristics. 
In addition, there is a natural analogy between the fluid handling capabilities of nanofluidic structures and the ability of electronic components to control the flow of electrons and holes. This analogy has been used to realize active electronic functions such as rectification 
and field-effect 
and bipolar transistor
action with ionic currents. Application of nanofluidics is also to nano-optics for producing tuneable microlens array
Nanofluidics have had a significant impact in biotechnology, medicine and clinical diagnostics with the development of lab-on-a-chip devices for PCR and related techniques. Attempts have been made to understand the behaviour of flowfields around nanoparticles in terms of fluid forces as a function of Reynolds and Knudsen number using computational fluid dynamics.  The relationship between lift, drag and Reynolds number has been shown to differ dramatically at the nanoscale compared with macroscale fluid dynamics.