Evans and his co-workers  has developed a strategy that relies heavily on asymmetric aldol methodology for the production of the polypropionate backbone. They used a Claisen condensation reaction to construct the C(13)–C(14) trisubstituted Z-olefin. The Evans synthesis of (+)-discodermolide has an overall yield of 6.4% with a longest linear sequence of 31 steps and 49 total steps.