Aciculitin A-C exhibits cytotoxicity against human colon tumor cell line HCT-116 with IC value of 0.5 μg/mL. 
Aciculitin D exhibits cytotoxicity against human colon tumor cell line HCT-116 with IC value of 0.51 μM. Aciculitin D also exhibits cytotoxicity against HeLa, human cervical cells with IC value of 0.57 μM.