Mitigation of adverse impacts of runoff can take several forms:
* Land use development controls aimed at minimizing impervious surfaces in urban areas
* Erosion controls for farms and construction sites
* Flood control and retrofit programs, such as green infrastructure 
* Chemical use and handling controls in agriculture, landscape maintenance, industrial use, etc.
Land use controls. Many world regulatory agencies have encouraged research on methods of minimizing total surface runoff by avoiding unnecessary hardscape. Many municipalities have produced guidelines and codes (zoning and related ordinances) for land developers that encourage minimum width sidewalks, use of pavers set in earth for driveways and walkways and other design techniques to allow maximum water infiltration in urban settings. An example of a local program specifying design requirements, construction practices and maintenance requirements for buildings and properties is in Santa Monica, California.  
Erosion controls have appeared since medieval times when farmers realized the importance of contour farming to protect soil resources. Beginning in the 1950s these agricultural methods became increasingly more sophisticated. In the 1960s some state and local governments began to focus their efforts on mitigation of construction runoff by requiring builders to implement erosion and sediment controls (ESCs).  This included such techniques as: use of straw bales and barriers to slow runoff on slopes, installation of silt fences, programming construction for months that have less rainfall and minimizing extent and duration of exposed graded areas. Montgomery County, Maryland implemented the first local government sediment control program in 1965, and this was followed by a statewide program in Maryland in 1970.
Flood control programs as early as the first half of the twentieth century became quantitative in predicting peak flows of riverine systems. Progressively strategies have been developed to minimize peak flows and also to reduce channel velocities. Some of the techniques commonly applied are: provision of holding ponds (also called detention basins or balancing lakes) to buffer riverine peak flows, use of energy dissipators in channels to reduce stream velocity and land use controls to minimize runoff.
Chemical use and handling. Following enactment of the U.S. Resource Conservation and Recovery Act (RCRA) in 1976, and later the Water Quality Act of 1987, states and cities have become more vigilant in controlling the containment and storage of toxic chemicals, thus preventing releases and leakage. Methods commonly applied are: requirements for double containment of underground storage tanks, registration of hazardous materials usage, reduction in numbers of allowed pesticides and more stringent regulation of fertilizers and herbicides in landscape maintenance. In many industrial cases, pretreatment of wastes is required, to minimize escape of pollutants into sanitary or stormwater sewers.
The U.S. Clean Water Act (CWA) requires that local governments in urbanized areas (as defined by the Census Bureau) obtain stormwater discharge permits for their drainage systems. Essentially this means that the locality must operate a stormwater management program for all surface runoff that enters the municipal separate storm sewer system ("MS4"). EPA and state regulations and related publications outline six basic components that each local program must contain:
* Public education (informing individuals, households, businesses about ways to avoid stormwater pollution)
* Public involvement (support public participation in implementation of local programs)
* Illicit discharge detection & elimination (removing sanitary sewer or other non-stormwater connections to the MS4)
* Construction site runoff controls (i.e. erosion and sediment controls)
* Post-construction (i.e. permanent) stormwater management controls
* Pollution prevention (e.g. improved chemical handling, including management of motor fuels and oil, fertilizers, pesticides and roadway deicers) and "good housekeeping" measures (e.g. system maintenance).
Other property owners which operate storm drain systems similar to municipalities, such as state highway systems, universities, military bases and prisons, are also subject to the MS4 permit requirements.