The initial adsorption of the molecule adhesive will also depend on the wetting between the adhesive and membrane. This can be described using Young's equation:
where  is the interfacial tension between the membrane and gas or bodily environment,  is the interfacial tension between the bioadhesive and membrane,  is the interfacial tension between the bioadhesive and bodily environment, and  is the contact angle of the bioadhesive on the membrane. The ideal contact angle is 0° meaning the bioadhesive perfectly wets the membrane and good contact is achieved. The interfacial tensions can be measured using common experimental techniques such as a Wilhelmy plate or the Du Noüy ring method to predict if the adhesive will make good contact with the membrane.