DCCC has been employed to separate a wide variety of phytochemicals from their crude extracts. The long list of natural product separations includes: saponins, alkaloids, senna glycosides, monosaccarides, triterpene glycosides, flavone glycosides, xanthones, iridoid glycosides, vitamin B, lignans, imbricatolic acid, gallic acid, carotenoids, and triterpenoids.
DCCC instruments have been commercially manufactured and distributed by Büchi and Tokyo Rikakikai (Eyela).