Overdoses of eszopiclone up to 90 times the recommended dose have been reported in which the patient fully recovered. Fatalities have been reported only in cases in which eszopiclone was combined with other drugs or alcohol. Overdose may be successfully treated with flumazenil, a GABA receptor antagonist used also for benzodiazepine overdose.
Poison control centers reported that between 2005 and 2006 there were 525 total eszopiclone overdoses recorded in the state of Texas, the majority of which were intentional suicide attempts.
If consumed within the last hour, eszopiclone overdose can be treated with the administration of activated charcoal or via gastric lavage.