Through supramolecular chemistry, pregel solution can solidify through reversible supramolecular interactions such as host-guest interactions. Such interaction can be manipulated through the mechanical force or the temperature. When energy exerted to the network is high enough, physical crosslinking point will break and the polymer will be at liquid state, after leaving the nozzle, the crosslinking can be rapidly formed to solidify the solution.
A case would be the Host–Guest Chemistry reported by Scherman et al. Where the formation of inclusion complex between [[Cucurbituril|Cucurbit[8]uril]] and [https://pubchem.ncbi.nlm.nih.gov/compound/1-Benzyl-3-methylimidazolium-bromide 1-benzyl-3-vinylimidazolium bromide] (BVIm) formed physical crosslinking point for the network. The formation of this physical crosslinking point is controlled by the temperature of the solution. By heating up the solution and cooling it down rapidly at extrusion nuzzle, the hydogel fiber is formed. Also, subsequent crosslinking is performed to form a perment network.