Negative regulators act to prevent transcription or translation. Examples such as cFLIP suppress cell death mechanisms leading to pathological disorders like cancer, and thus play a crucial role in drug resistance. Circumvention of such actors is a challenge in cancer therapy. 
Negative regulators of cell death in cancer include cFLIP, Bcl family, Survivin, HSP, IAP, NF-κB, Akt, mTOR, and FADD.