* Phosphofructokinase 1 catalyzes the first committed step of glycolysis.
* LpxC catalyzes the first committed step of lipid A biosynthesis.
* 8-amino-7-oxononanoate synthase catalyzes the first committed step in plant biotin synthesis.
* MurA catalyzes the first committed step of peptidoglycan biosynthesis.
*Aspartate transcarbamoylase catalyzes the committed step in the pyrimidine biosynthetic pathway in E. coli.
*3-deoxy-D-arabinose-heptulsonate 7-phosphate synthase catalyses the first committed step of the shikimate pathway responsible for the synthesis of the aromatic amino acids Tyrosine, Tryptophan and Phenylalanine in plants, bacteria, fungi and some lower eukaryotes.
*Citrate synthase catalyzes the addition of acetyl-CoA to oxaloacetate and is the first committed step of the Citric Acid Cycle.
*Acetyl-CoA carboxylase catalyzes the irreversible carboxylation of acetyl-CoA to malonyl-CoA in the first committed step of fatty acid biosynthesis.
*Glucose-6-phosphate dehydrogenase catalyzes the conversion of G6P into 6-phosphogluconolactone to produce NADPH in the first and committed step of the pentose phosphate pathway.