Equilibrium isotope fractionation is the partial separation of isotopes between two or more substances in chemical equilibrium. Equilibrium fractionation is strongest at low temperatures, and (along with kinetic isotope effects) forms the basis of the most widely used isotopic paleothermometers (or climate proxies): D/H and O/O records from ice cores, and O/O records from calcium carbonate. It is thus important for the construction of geologic temperature records. Isotopic fractionations attributed to equilibrium processes have been observed in many elements, from hydrogen (D/H) to uranium (U/U). In general, the light elements (especially hydrogen, boron, carbon, nitrogen, oxygen and sulfur) are most susceptible to fractionation, and their isotopes tend to be separated to a greater degree than heavier elements.