Cyanosulfidic chemistry has several limitations. While the products are all formed from the same starting materials, many of the reactions require the periodic delivery of new reagents which complicates the syntheses. The chemical synthesis is therefore not truly “one-pot” chemistry which would require all reactants to be provided at the beginning which no further alterations. Sutherland and colleagues argue that a “flow-chemistry” approach featuring the movement of compounds through a stream experiencing different geochemical conditions makes their proposed system plausible.