The asymmetric hydrogenation of indoles has been established with N-Boc protection.
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A Pd(TFA)/H8-BINAP system achieves the enantioselective cis-hydrogenation of 2,3- and 2-substituted indoles.
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Akin to the behavior of indoles, pyrroles can be converted to pyrrolidines by asymmetric hydrogenation.
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