Carbon-carbon bond activation reactions have numerous applications in organic synthesis, materials science, and pharmaceuticals. In organic synthesis, these reactions are used to construct complex molecules in a highly efficient and selective manner. For example, in 2021 Dong Group described the first enantioselective total synthesis of the natural product penicibilaenes using a late-stage carbon-carbon bond activation strategy. There are also a lot of other examples highlighting the potential of carbon-carbon bond activation strategies in the total synthesis of complex natural products with high stereocontrol.