By integrating the above four data sets, CTD automatically constructs putative chemical-gene-phenotype-disease networks to illuminate molecular mechanisms underlying environmentally-influenced diseases.
These inferred relationships are statistically scored and ranked and can be used by scientists and computational biologists to generate and verify testable hypotheses about toxicogenomic mechanisms and how they relate to human health.
Users can search CTD to explore scientific data for chemicals, genes, diseases, or interactions between any of these three concepts.  Currently, CTD integrates toxicogenomic data for vertebrates and invertebrates.
CTD integrates data from or hyperlinks to these databases:
*ChemIDplus,  a dictionary of more than 400,000 chemicals housed in the US National Library of Medicine
*DrugBank
*Data Infrastructure for Chemical Safety project (diXa) Data Warehouse by the European Bioinformatics Institute which as of November 2015 contained 469 compounds, 188 disease datasets in three sub-categories liver, kidney and cardiovascular disease.
*Gene Ontology Consortium
*KEGG
*NCBI Entrez-Gene
*NCBI PubMed
*NCBI Taxonomy
*NLM Medical Subject Headings
*OMIM
*Reactome