Aminosulfuranes compare favorably with many of the other fluorination methods available. They are easier to handle than sulfur tetrafluoride; however SF does not promote cationic rearrangements. With respect to carboxylic acids, aminosulfuranes and SF are complementary: the former gives acid fluorides, while the latter gives trifluoromethyl compounds.
Perfluorinated alkylamines, such as Ishikawas reagent (N,N'-diethyl-1,1,2,3,3,3-hexafluoropropylamine WRONG MOLECULE IN SCHEME BELOW), are highly selective for hydroxyl groups and do not react with aldehydes and ketones. The amide byproducts of these reagents, however, are harder to separate from the desired products than aminosulfurane byproducts.
Alkali and tetraalkylammonium fluorides can be used to displace sulfonate esters; however, these reactions require higher temperatures than aminosulfurane fluorination of the corresponding free alcohols.