Some polymer solutions have an LCST at temperatures higher than the UCST. As shown in the diagram, this means that there is a temperature interval of complete miscibility, with partial miscibility at both higher and lower temperatures.
In the case of polymer solutions, the LCST also depends on polymer degree of polymerization, polydispersity and branching as well as on the polymer's composition and architecture.  One of the most studied polymers whose aqueous solutions exhibit LCST is poly(N-isopropylacrylamide). Although it is widely believed that this phase transition occurs at , the actual temperatures may differ 5 to 10 °C (or even more) depending on the polymer concentration, molar mass of polymer chains, polymer dispersity as well as terminal moieties. Furthermore, other molecules in the polymer solution, such as salts or proteins, can alter the cloud point temperature. Another monomer whose homo- and co-polymers exhibit LCST behavior in solution is 2-(dimethylamino)ethyl methacrylate.
The LCST depends on the polymer preparation and in the case of copolymers, the monomer ratios, as well as the hydrophobic or hydrophilic nature of the polymer.
To date, over 70 examples of non-ionic polymers with an LCST in aqueous solution have been found.