DEAD is an efficient component in Diels-Alder reactions and in click chemistry, for example the synthesis of bicyclo[2.1.0]pentane, which originates from Otto Diels. It has also been used to generate aza-Baylis-Hillman adducts with acrylates.
DEAD can be used for synthesis of heterocyclic compounds. Thus, pyrazoline derivatives convert by condensation to α,β-unsaturated ketones:
Another application is the use of DEAD as an enophile in ene reactions: