During the Mississippian period (800–1600 CE, varying locally), elites at major political and religious centers throughout the midwestern and southeastern United States used copper ornamentation as a sign of their status by crafting the sacred material into representations connected with the Chiefly Warrior cult of the Southeastern Ceremonial Complex (S.E.C.C.).
This ornamentation includes Mississippian copper plates, repousséd plates of beaten copper now found as far afield as Alabama, Florida, Georgia, Illinois, Mississippi, Oklahoma, and Tennessee. Some of the more famous of the plates are of raptorial birds and avian-themed dancing warriors. These plates, such as the Rogan plates from Etowah, the Spiro plates from the Spiro in Oklahoma, and the Wulfing cache from southeast Missouri, were instrumental in the development of the archaeological concept known as the S.E.C.C.
The only Mississippian culture site where a copper workshop has been located by archaeologists is Cahokia in western Illinois, where a copper workshop dating to the Moorehead Phase () was identified at Mound 34. Gregory Perino identified the site in 1956 and archaeologists subsequently excavated it.
Numerous copper fragments were found at the site; metallographic analysis indicated that Mississippian copper workers worked copper into thin sheet through repeated hammering and annealing, a process that could be successful over open-pit wood fires.
After the collapse of the Mississippian way of life in the 1500s with the advent of European colonization, copper still retained a place in Native American religious life as a special material. Copper was traditionally regarded as sacred by many historic period Eastern tribes. Copper nuggets are included in medicine bundles among Great Lakes tribes. Among 19th century Muscogee Creeks, a group of copper plates carried along the Trail of Tears are regarded as some of the tribe's most sacred items.