Although there are numerous benefits in using the SQT approach, drawbacks in its use have been identified. The major limitations include: lack of statistical criteria development within the framework, large database requirements, difficulties in chemical mixture application, and data interpretation can be laboratory intensive (Chapman 1989). The SQT does not evidently consider the bioavailability of complexed or sediment-associated contaminants (FDEP 1994). Lastly, it is difficult to translate laboratory toxicity results to biological effects seen in the field (Kamlet 1989).