These advancements have produced five main types of Conia-ene reactions characterized by the operative activation mode: namely, enolate, alkyne, or ene-yne activation, and one- or two-metal dual activation. Note that though the mechanisms of Conia-ene variants differ from the initial ene-like cyclization, they are still considered Conia-ene or Conia-ene-type reactions. In addition, due to the complexity of some Conia-ene reaction systems, the true mechanism may lay somewhere between several different activation modes.