Diazirines have been used in photoaffinity labeling experiments involving nucleic acids as well. Examples include:
* Incorporation of a diazirine moiety on a nucleoside sugar in a DNA polymer to investigate interactions between the minor groove of DNA and DNA polymerases.
* Incorporation of a diazirine moiety on a nucleoside base in a DNA polymer to investigate the mode of DNA repair by proteins.
Diazirines have also been used to study protein lipid interactions, for example the interaction of various sphingolipids with proteins in vivo.