* An ingredient in diesel exhaust fluid (DEF), which is 32.5% urea and 67.5% de-ionized water. DEF is sprayed into the exhaust stream of diesel vehicles to break down dangerous  emissions into harmless nitrogen and water.
* A component of animal feed, providing a relatively cheap source of nitrogen to promote growth
* A non-corroding alternative to rock salt for road de-icing. It is often the main ingredient of pet friendly salt substitutes although it is less effective than traditional rock salt or calcium chloride.
* A main ingredient in hair removers such as Nair and Veet
* A browning agent in factory-produced pretzels
* An ingredient in some skin cream, moisturizers, hair conditioners, and shampoos
* A cloud seeding agent, along with other salts
* A flame-proofing agent, commonly used in dry chemical fire extinguisher charges such as the urea-potassium bicarbonate mixture
* An ingredient in many tooth whitening products
* An ingredient in dish soap
* Along with diammonium phosphate, as a yeast nutrient, for fermentation of sugars into ethanol
* A nutrient used by plankton in ocean nourishment experiments for geoengineering purposes
* As an additive to extend the working temperature and open time of hide glue
* As a solubility-enhancing and moisture-retaining additive to dye baths for textile dyeing or printing
* As an optical parametric oscillator in nonlinear optics