The P-N bond is susceptible to attack by protic reagents.  Alcoholysis occurs readily:
:PhPNEt  +  ROH   →   PhPOR  +  HNEt
The P-N bond reverts to the chloride upon treatment with anhydrous hydrogen chloride:
:PhPNEt  +  2 HCl   →   PhPCl  +  [HNEt]Cl
Similarly, transamination is used in the conversion of one aminophosphine to another:
:P(NMe) + RNH    P(NR)(NMe)  +  HNMe
With tris(dimethylamino)phosphine is a reactant, the equilibrium can be driven by evaporation of dimethylamine.
Since the P-NR bond is not attacked by Grignard reagents, aminophosphine chlorides are useful reagents in the preparation of unsymmetrical tertiary phosphines.  Illustrative is the conversion of dimethylaminophosphorus dichloride to chlorodimethylphosphine:
:2 MeMgBr  +  MeNPCl  →  MeNPMe  +  2 MgBrCl
:MeNPMe  +  2 HCl  →  ClPMe  +  MeNHCl
Illustrative also is the chemistry of 1,2-bis(dichlorophosphino)benzene, a versatile precursor to diphosphine ligands, is prepared using aminophosphine reagents.  It is prepared from 1,2-dibromobenzene via lithiation and treatment with (EtN)PCl (Et = ethyl).  This route gives CH[P(NEt)], which is treated with hydrogen chloride:
:CH[P(NEt)]  +  8 HCl  →   CH(PCl)  +  4 EtNHCl