Adhesion GPCRs are found in fungi.  They are believed to have evolved from the  cAMP receptor family, arising approximately 1275 million years ago before the split of Unikonts from a common ancestor. Several fungi have novel adhesion GPCRs that have both short, 2–66 amino acid residues, and long, 312–4202 amino acid residues. Analysis of fungi showed that there were no secretin receptor family GPCRs, which suggests that they evolved from adhesion GPCRs in a later organism.
Genome analysis of the Teleost Takifugu rubripes has revealed that it has only two adhesion GPCRs that showed homology to Ig-hepta/GPR116.  While the Fugu genome is relatively compact and limited with the number of adhesion GPCRs, Tetraodon nigroviridis, another species of puffer fish, has considerably more, totaling 29 adhesion GPCRs.