Ratsimamanga married Suzanne Urverg-Ratsimamanga on 23 March 1963. She was a French Ashkenazi Jewish biochemist, a Fellow of the World Academy of Sciences (1989), and the African Academy of Sciences (1987), and IMRAs Chair  and Alberts closest collaborator. With Albert, she co-founded "Albert and Suzanne Rakoto Ratsimamanga Foundation" within IMRA.
Ratsimamanga died on 16 September 2001, aged 93, in Antananarivo, Madagascar. A state funeral was held for him.