In organic chemistry, the Malaprade reaction or Malaprade oxidation is a glycol cleavage reaction in which a vicinal diol is oxidized by periodic acid or a periodate salt to give the corresponding carbonyl functional groups. The reaction was first reported by Léon Malaprade in 1928.  Amino alcohols are also cleaved.
In terms of mechanism, the reaction is thought to proceed by a cyclic diester of iodine(VII).