The synthesis of borjatriol involved the rare isolation of a migrated epoxide. The diastereomeric mixture of rearrangement products was carried through the remainder of the synthesis.
The final two steps in the total synthesis of spatol involved intramolecular electrophilic trapping of an alkoxide derived from a rearranged epoxide. Attack of the intermediate alkoxide on the adjacent mesylate afforded a bis(epoxide), and debenzylation provided the target compound.