Different rules (4n, 5n, or 6n) are invoked depending on the number of electrons per vertex.
The 4n rules are reasonably accurate in predicting the structures of clusters having about 4 electrons per vertex, as is the case for many boranes and carboranes.  For such clusters, the structures are based on deltahedra, which are polyhedra in which every face is triangular. The 4n clusters are classified as closo-, nido-, arachno- or hypho-, based on whether they represent a complete (closo-) deltahedron, or a deltahedron that is missing one (nido-), two (arachno-) or three (hypho-) vertices.
However, hypho clusters are relatively uncommon due to the fact that the electron count is high enough to start to fill antibonding orbitals and destabilize the 4n structure. If the electron count is close to 5 electrons per vertex, the structure often changes to one governed by the 5n rules, which are based on 3-connected polyhedra.
As the electron count increases further, the structures of clusters with 5n electron counts become unstable, so the 6n rules can be implemented. The 6n clusters have structures that are based on rings.
A molecular orbital treatment can be used to rationalize the bonding of cluster compounds of the 4n, 5n, and 6n types.