Dioxiranes are derivatives of this parent in which the hydrogens are replaced by other groups. Difluorodioxirane, which boils at about –80 to –90 °C, is one of the very few dioxirane derivatives that is stable in pure form at room temperature and is thermodynamically stable (ΔH° = –104 kcal/mol).  Dimesityldioxirane is another relatively stable derivative which has been characterized by X-ray crystallography.
Dimethyldioxirane (DMDO) and the still more reactive methyl(trifluoromethyl)dioxirane have seen some use in organic synthesis, Dioxiranes are intermediate in the Shi epoxidation reaction.