The phosphatome includes proteins that are structurally closely related to phosphatases but lack catalytic activity. These retain biological function, and may regulate pathways that involve active phosphatases, or bind to phosphorylated substrates without cleaving them. Examples include [https://www.ncbi.nlm.nih.gov/gene/6815 STYX], where the phosphatase domain has become a phospho-tyrosine binding domain, and [https://www.ncbi.nlm.nih.gov/gene/2580 GAK], whose inactive phosphatase domain instead binds phospholipids.