Vigilant caution should be taken while using TRIzol (due to the phenol and chloroform). 
TRIzol is labeled as acute oral, dermal, and inhalation toxicity besides skin corrosion/irritation in the manufacturer MDS.
Exposure to TRIzol can be a serious health hazard. Exposure can lead to serious chemical burns, permanent scarring and kidney failure. 
Experiments should be performed under a chemical hood, with lab coat, nitrile gloves and a plastic apron. 
TRIzol waste should never be mixed with bleach or acids: the guanidinium thiocyanate in TRIzol reacts to form highly toxic gases.