It is possible that specific molecules are dissolved in lyotropic mesophases, where they can be located mainly inside, outside, or at the surface of the aggregates.
Some of such molecules act as dopants, inducing specific properties to the whole phase, other ones can be considered simple guests with limited effect on the surrounding environment but possibly strong consequences on their physico-chemical properties, and some of them are used as probe to detect molecular-level properties of the whole mesophase in specific analytical techniques.