R-454B, also known by the trademarked names Opteon XL41, Solstice 454B, and Puron Advance, is a zeotropic blend of 68.9 percent difluoromethane (R-32), a hydrofluorocarbon, and 31.1 percent 2,3,3,3-tetrafluoropropene (R-1234yf), a hydrofluoroolefin. Because of its reduced global warming potential (GWP), R-454B is intended to be an alternative to refrigerant R-410A in new equipment. R-454B has a GWP of 466, which is 78 percent lower than R-410A's GWP of 2088.
R-454B is non-toxic and mildly flammable, with an ASHRAE safety classification of A2L. In the United States, it is expected to be packaged in a container that is red or has a red band on the shoulder or top.