There is no conclusive evidence that thalidomide or lenalidomide is useful to bring about or maintain remission in Crohn's disease.
Thalidomide was studied in a Phase II trial for Kaposis sarcoma, a rare soft-tissue cancer most commonly seen in the immunocompromised, that is caused by the Kaposis sarcoma-associated herpesvirus (KSHV).
* AIDS wasting syndrome, associated diarrhea
* Renal cell carcinoma (RCC)
* Glioblastoma multiforme
* Prostate cancer
* Melanoma
* Colorectal cancer
* Crohn's disease 
* Rheumatoid arthritis
* Behcet's syndrome
* Breast cancer
* Head and neck cancer
* Ovarian cancer
* Chronic heart failure
* Graft-versus-host disease
* Tuberculous meningitis