EPIC-seq enables the subclassification of NSCLC into histological subtypes such as lung adenocarcinoma (LUAD) and lung squamous cell carcinoma (LUSC). EPIC-seq can also aid with the classification of cell-of-origin (COO) subtypes in DLBCL. By analyzing epigenetic and transcriptional signatures, EPIC-seq-derived classifiers provide valuable insights into tumor heterogeneity and molecular subtyping , providing valuable insights for tailored treatment strategies.