Lamina-associated domains (LADs) are parts of the chromatin that heavily interact with the lamina, a network-like structure at the inner membrane of the nucleus. LADs consist mostly of transcriptionally silent chromatin, being enriched with trimethylated Lys27 on histone H3, (i.e. H3K27me3); which is a common posttranslational histone modification of heterochromatin. LADs have CTCF-binding sites at their periphery.