Unlike the human body, typical chemical reactions are unable to regenerate the cofactor for further use. Synthetic cofactors have been researched to solve this problem. The analogues have been synthesized from similar compounds such as 1,4-dihydronicotinamide. These synthetic cofactors have since been used to better understand the mechanisms of reactions especially when it comes to stereospecificity, which may be enhanced by metal ions. Analogues serve as an alternative to traditional regeneration techniques.