Levofloxacin is rapidly and essentially completely absorbed after oral administration, with a plasma concentration profile over time that is essentially identical to that obtained from intravenous administration of the same amount over 60 minutes.  As such, the intravenous and oral formulations of levofloxacin are considered interchangeable. Levofloxacin's ability to bind to proteins in the body ranges from 24 to 38%.
The drug undergoes widespread distribution into body tissues.  Peak levels in skin are achieved 3 hours after administration and exceed those in plasma by a factor of 2. Similarly, lung tissue concentrations range from two-fold to five-fold higher than plasma concentrations in the 24 hours after a single dose.
The mean terminal plasma elimination half-life of levofloxacin ranges from approximately 6 to 8 hours following single or multiple doses of levofloxacin given orally or intravenously. Elimination occurs mainly via excretion of unmetabolized drug in the urine.  Following oral administration, 87% of an administered dose was recovered in the urine as unchanged drug within 2 days.  Less than 5% was recovered in the urine as the desmethyl and N-oxide metabolites, the only metabolites identified in humans.