LOV domains have been found to control gene expression through DNA binding and
to be involved in redox-dependent regulation, like e.g. in the bacterium Rhodobacter sphaeroides. Notably, LOV-based optogenetic tools  have been gaining wide popularity in recent years to control a myriad of cellular events, including cell motility, subcellular organelle distribution, formation of membrane contact sites, microtubule dynamics, transcription,  and protein degradation.