Pyridine is not abundant in nature, except for the leaves and roots of belladonna (Atropa belladonna) and in marshmallow (Althaea officinalis). Pyridine derivatives, however, are often part of biomolecules such as alkaloids.
In daily life, trace amounts of pyridine are components of the volatile organic compounds that are produced in roasting and canning processes, e.g. in fried chicken, sukiyaki, roasted coffee, potato chips, and fried bacon. Traces of pyridine can be found in Beaufort cheese, vaginal secretions, black tea, saliva of those suffering from gingivitis, and sunflower honey.