β-Catenin has been shown to interact with:
* APC, 
* AXIN1, 
* Androgen receptor, 
* CBY1, 
* CDH1, 
* CDH2, 
* CDH3, 
* CDK5R1, 
* CHUK, 
* CTNND1, 
* CTNNA1, 
* EGFR, 
* Emerin
* ESR1 
* FHL2, 
* GSK3B, 
* HER2/neu, 
* HNF4A, 
* IKK2, 
* LEF1 including transgenically, 
* MAGI1, 
* MUC1, 
* NR5A1, 
* PCAF, 
* PHF17, 
* Plakoglobin, 
* PTPN14, 
* PTPRF, 
* PTPRK (PTPkappa),
*PTPRT (PTPrho),
*PTPRU (PCP-2),
* PSEN1, 
* PTK7
* RuvB-like 1, 
* SMAD7, 
* SMARCA4 
* SLC9A3R1, 
* USP9X,  and
* VE-cadherin.
* XIRP1