Epilepsy is a neurological condition marked by recurring seizures. It occurs when the brain's electrical activity becomes unbalanced, leading to repeated seizures. These seizures disrupt the normal electrical patterns in the brain, causing sudden and synchronized bursts of electrical energy. As a result, individuals may experience temporary changes in consciousness, movements, or sensations.
Glutamate excitotoxicity is thought to play an important role in the initiation and maintenance of epileptic seizures. The seizure-induced high flux of glutamate overstimulated glutamate receptors, which triggered a chain reaction of excitation in glutamatergic networks.