Another strategy that has been explored is the stabilization of reactions that develop partial negative charges in the transition state. Examples of successful applications are most commonly reactions that are approximated concerted and pericyclic in nature. During the course of the reaction, one fragment develops partial negative character and the transition state can be stabilized by accepting hydrogen bond(s).
A demonstrative example is the catalysis of Claisen rearrangements of ester-substituted allyl vinyl ethers reported by the Jacobsen research group. A chiral guanidinium catalyst was found to successfully promote the reaction near room temperature with high enantioselectivity. During the transition state, the fragment coordinated to the amidinium catalyst develops partial anionic character due to the electronegativity of the oxygen and the electron-withdrawing ester group.  This increases the strength of hydrogen bonding and lowers the transition state energy, thus accelerating the reaction.
Similarly, negative charge can develop in cycloaddition reactions such as the Diels-Alder reaction, when the partners are appropriately substituted. As a representative example, Rawal and coworkers developed a chiral catalyst based on α,α,α,α-tetraaryl-1,3-dioxolane-4,5-dimethanol (TADDOL) that could catalyze Diels-Alder reactions. In the following example, the reaction with a highly electron-rich diene and an electron-poor dienophile is thought to develop significant negative charge on the enal fragment, and is the transition state is stabilized by increased hydrogen bonding to the TADDOL (Ar = 1-naphthyl).