On some other instances in biology (not necessarily about cell signaling), the term "Scaffold protein" is used in a broader sense, where a protein holds several things together for any purpose. 
;In chromosome folding: Chromosome scaffold has important role to hold the chromatin into compact chromosome. Chromosome scaffold is made of proteins including condensin, topoisomerase IIα  and kinesin family member 4 (KIF4) Chromosome scaffold constituent proteins are also called scaffold protein. 
;In enzymatic reaction: Large multifunctional enzymes that performs a series or chain of reaction in a common pathway, sometimes called scaffold proteins. such as Pyruvate dehydrogenase. 
;In molecule shape formation:  An enzyme or structural protein that holds several molecules together to hold them in proper spatial arrangement, such as Iron sulphur cluster scaffold proteins.
;Structural scaffold: In cytoskeleton and ECM, the molecules provide mechanical scaffold. Such as type 4 collagen