Carboxylic acids, amides, esters, and carboxylate salts convert to the trifluoromethyl derivatives, although conditions vary widely:
For carboxlic acids, the first step gives the acyl fluorides, in keeping with the tendency of SF to fluorinate acidic hydroxyl groups:
Similarly SF converts sulfonic acids to sulfonyl fluorides:
Aldehydes and ketones convert to geminal difluorides:
Alcohols convert to alkyl fluorides, although this conversion works best with acidic alcohols, such as fluorinated alcohols: