*Bacterial meningitis; an aminoglycoside can be added to increase efficacy against gram-negative meningitis bacteria
*Endocarditis by enterococcal strains (off-label use); often given with an aminoglycoside
*Gastrointestinal infections caused by contaminated water or food (for example, by Salmonella)
*Genito-urinary tract infections
*Healthcare-associated infections that are related to infections from using urinary catheters and that are unresponsive to other medications
*Otitis media (middle ear infection)
*Prophylaxis (i.e. to prevent infection) in those who previously had rheumatic heart disease or are undergoing dental procedures, vaginal hysterectomies, or C-sections. It is also used in pregnant woman who are carriers of group B streptococci to prevent early-onset neonatal infections.
*Respiratory infections, including bronchitis, pharyngitis
*Sinusitis
*Sepsis
*Whooping cough, to prevent and treat secondary infections
Ampicillin used to also be used to treat gonorrhea, but there are now too many strains resistant to penicillins.