TMSCl is reactive toward nucleophiles, resulting in the replacement of the chloride.  In a characteristic reaction of TMSCl, the nucleophile is water, resulting in hydrolysis to give the hexamethyldisiloxane:
The related reaction of trimethylsilyl chloride with alcohols can be exploited to produce anhydrous solutions of hydrochloric acid in alcohols, which find use in the mild synthesis of esters from carboxylic acids and nitriles as well as, acetals from ketones.  Similarly, trimethylsilyl chloride is also used to silanize laboratory glassware, making the surfaces more lipophilic.