Polyelectrolytes that bear both cationic and anionic repeat groups are called polyampholytes. The competition between the acid-base equilibria of these groups leads to additional complications in their physical behavior. These polymers usually only dissolve when sufficient added salt screens the interactions between oppositely charged segments. In the case of amphoteric macroporous hydrogels, the action of concentrated salt solution does not lead to the dissolution of polyampholyte material due to the covalent cross-linking of macromolecules. Synthetic 3-D macroporous hydrogels shows the excellent ability to adsorb heavy-metal ions in a wide range of pH from extremely diluted aqueous solutions, which can be later used as an adsorbent for purification of salty water All proteins are polyampholytes, as some amino acids tend to be acidic, while others are basic.