pRb is known to interact with more than 300 proteins, some of which are listed below:
* Abl gene
* Androgen receptor
* Apoptosis-antagonizing transcription factor
* ARID4A
* Aryl hydrocarbon receptor
* BRCA1
* BRF1
* C-jun
* C-Raf
* CDK9
* CUTL1
* Cyclin A1
* Cyclin D1
* Cyclin T2
* DNMT1
* E2F1
* E2F2,
* E4F1
* EID1
* ENC1
* FRK
* HBP1
* HDAC1
* HDAC3
* Histone deacetylase 2
* Insulin
* JARID1A
* Large tumor antigen
* LIN9
* MCM7
* MORF4L1
* MRFAP1,
* MyoD
* NCOA6
* PA2G4
* Peroxisome proliferator-activated receptor gamma
* PIK3R3
* Plasminogen activator inhibitor-2
* Polymerase (DNA directed), alpha 1
* PRDM2
* PRKRA
* Prohibitin
* Promyelocytic leukemia protein
* RBBP4
* RBBP7
* RBBP8
* RBBP9
* SNAPC1
* SKP2
* SNAPC3
* SNW1
* SUV39H1
* TAF1
* THOC1
* TRAP1
* TRIP11
* UBTF
* USP4.