-Hb dissociation curve is a sigmoidal curve that represents the relationship between O concentration and the percentage saturation of Hb. As the concentration increases from about 90% there is a plateau in the curve that has several important biological implications.|right|thumb|300px||
The oxygen–hemoglobin dissociation curve, also called the oxyhemoglobin dissociation curve or oxygen dissociation curve (ODC), is a curve that plots the proportion of hemoglobin in its saturated (oxygen-laden) form on the vertical axis against the prevailing oxygen tension on the horizontal axis. This curve is an important tool for understanding how our blood carries and releases oxygen. Specifically, the oxyhemoglobin dissociation curve relates oxygen saturation (S) and partial pressure of oxygen in the blood (P), and is determined by what is called "hemoglobin affinity for oxygen"; that is, how readily hemoglobin acquires and releases oxygen molecules into the fluid that surrounds it.