2,2-Dimethoxypropane (DMP) is an organic compound with the formula (CH)C(OCH). A colorless liquid, it is the product of the condensation of acetone and methanol. DMP is used as a water scavenger in water-sensitive reactions. Upon acid-catalyzed reaction, DMP reacts quantitatively with water to form acetone and methanol. This property can be used to accurately determine the amount of water in a sample, alternatively to the Karl Fischer method.
DMP is specifically used to prepare acetonides:
:RCHOHCHOHCH + (MeO)CMe → RCHCHCHOCMe + 2 MeOH
Dimethoxypropane is an intermediate for the synthesis of 2-methoxypropene.
In histology, DMP is used for the dehydration of animal tissue.