Iridium-catalyzed transfer-hydrogenative carbonyl allylation method has been applied to the synthesis of polyketide natural products. Some examples are shown below. In every case, the target compound was prepared in significantly fewer steps than was previously achieved. For example, total syntheses of roxaticin, bryostatin and cryptocaryol were accomplished via double Krische allylation of 1,3-propane diol. This method was also used in the synthesis of mandelalide A.
The Krische bisallylation has been applied to the synthesis of psymberin in 17 LLS and 32 total steps. Through the use of the Krische allylation, this synthesis was accomplished via a much shorter route than previous syntheses. The Krische allylation to his synthesis of callyspongiolide using the chiral SEGPHOS catalyst complex. ] In 2018, Harran also prepared callyspongiolide using the Krische allylation as a convergent method for fragment union. Double crotylation was used by Krische to prepare 6-deoxyerythronolide B and swinholide A.