In Marfan syndrome, a connective tissue disorder, mutations in the gene encoding for the fibrillin-1 protein impact nearly every one of its domains. Such defects in fibrillin-1 affect the signaling of TGFβ, as microfibrils directly govern the activity of TGFβ. This hinders the formation of the extracellular matrix, and ultimately results in a severe phenotype which involves a few organ systems, including the central nervous system, circulatory system, ocular system, and skeletal system.