There have been several enantioselective versions of this reaction developed, and even employed in synthesis of complex molecules. Hoyvedas synthesis of (R')-(-)-sporochnol included an asymmetric copper-catalyzed allylic substitution with an organozinc nucleophile and peptide ligand.
A TaniaPHOS ligand, a ferrocenylphosphine, is used with a methyl Grignard nucleophile to form an allylic stereocenter towards the total synthesis of (S)-(-)-Zearalenone
Allylic substitutions are one class of the several types of reactions carried out by organocuprate reagents.