Aside from total synthesis, a potentially useful application of hydrogen-bond catalysis is the bulk synthesis of difficult-to-access chiral small molecules. A notable example is the gram-scale Strecker synthesis of unnatural amino acids using thiourea catalysis, reported in the journal Nature in 2009. The catalyst, whether polymer-bound or homogeneous, is derived from natural tert-leucine and can catalyze (4 mol% catalyst loading) the formation of the Strecker product from benzhydryl amines and aqueous HCN. Hydrolysis of the nitrile and deprotections produces pure unnatural tert-leucine in 84% overall yield and 99% ee.