Besides education, CrysTBox is mainly used in research with fields of application spanning from nuclear research to archaeology and paleontology. Among others, the suite was employed in development of additive manufacturing (including 3D printed biodegradable alloys, metallic glass or high-entropy alloys), resistant coatings, laser shock peening, water cleaning technologies or characterization of 50 million years old flint.
Institutions whose research was supported by CrysTBox include educational facilities such as ETH Zurich, University of California, Uppsala University, Oxford University, University of Waterloo, Indian Institute of Technology, Nanyang Technological University or University of Tokyo as well as research institutes like Max Planck Institutes, Chinese Academy of Sciences, Fraunhofer Institutes or US national laboratories (NL) such as Oak Ridge NL, Lawrence Berkeley NL, Idaho NL and Lawrence Livermoore NL.