Another approach to evaluation of ion suppression is to make a comparison between:
* Detector response of calibration standard (either aqueous or in another suitable solvent) - This gives the best case scenario for detector response, i.e. under conditions of zero ion suppression
* Pre-prepared sample matrix spiked with an identical concentration of analyte - This demonstrates the effect of ion suppression
* Detector response of sample matrix spiked with an identical concentration of analyte and subjected to the usual sample preparation procedure - This can demonstrate the difference between any signal loss due to under-recovery during the sample preparation process and true ion suppression