Metal pollution in soil will induce high toxicity in hemp plants. Cadmium (Cd) toxicity has been proven to be long term and irreversible in plants. Cd specifically results in oxidative stress and increase in free radicals. Free radicals are found to cause oxidative stress, cell damage, and death. Hemp plants in Cd polluted soils were found to help detoxify the metal while the plants were still conserved. While growth in these hemp plants were slightly reduced when planted in Cd concentration soil, continued plant growth indicated hemp plants were able to detoxify some Cd. Specifically, transporter proteins would move Cd into the cell wall and differentially expressed genes (DEGs) would activate, bind, and defend against Cd stress. These DEGs were found to be involved in cell wall metabolism and were most active when in contact with Cd. The plant hormone ABA plays an important role in activating signal transduction cascades and cell cycling and growth. An increase of ABC transporters in hemp plants contributes to increases in calcium concentration, indicating that calcium-binding proteins can control Cd concentration and absorption.