*In the United States, the CDC first tested samples from the general population for lead and a few pesticides in 1976. In the late 1990s, the National Health and Nutrition Examination Survey (NHANES) program had a major expansion.
*National Report on Human Exposure to Environmental Chemicals
The CDCs Division of Laboratory Sciences within the National Center for Environmental Health has developed a National Biomonitoring Program, and has published the biennial National Report on Human Exposure to Environmental Chemicals' since 2001. As the selection of chemicals is controversial, the CDC has identified influential criteria:Evidence of exposure in a U.S. population, presence and significance of health effects after a given level of exposure, desire to track public health initiatives to reduce exposure to a given agent, existing method for accurately measuring biologically relevant concentrations of the chemical, sufficient tissue specimens, in particular, blood and/or urine samples and cost-effectiveness.
CDC established three criteria for removing chemicals from future surveys: a new replacement chemical (i.e., a metabolite or other chemical) is more representative of exposure than the chemical currently measured, or if after three survey periods, detection rates for all chemicals within a method-related group are less than 5 percent for all population subgroups (i.e., two sexes, three race/ethnicity groups, and the age groups used in the National Report), or if after three survey periods, levels of chemicals within a method-related group are unchanged or declining in all demographic subgroups documented in the National Report.
* The National Childrens Study plans to follow 100,000 children across the United States from birth until age 21. The study was authorized as part of the Childrens Health Act of 2000 as the largest effort undertaken to address the effects of social, economic and environmental factors on a childs health. the CDCs Environmental Health Laboratory announced in 2009 it would play a key role in the biomonitoring of the ongoing National Children's Study. In collaboration with the National Institute of Child Health and Development, National Institute of Environmental Health Sciences and U.S. Environmental Protection Agency.
*Some U.S. states have received federal support and established biomonitoring programs. In 2001, the CDC awarded planning grants to 33 states to assist in capacity building for expanding biomonitoring. 
**The California Environmental Contaminant Biomonitoring Program (CECBP) was established by law in 2006 and is administered by the California Department of Public Health.
**Minnesota's Biomonitoring Pilot Program was established by law in 2007 and is run by the Minnesota Department of Health.