"以补为喜"的心理需求，"东亚病夫"的社会不安和"强种保国"的观念是人造自来血在近代风靡的社会原因。企业顺应时局变化，在"辛亥革命"后，利用"共和"的必然趋势宣传产品，既迎合了统治阶层的意愿和需要，也顺应了民众的健康需求。
"Artificial plasma" was fashionable on the market, because the customers joyfully have requirements of nourishing live psychologically, fear being "sick man of Asia" and hopefully strengthen the race and country. After the Revolution of 1911, the companies wanted to meet not only the need and requirement of the ruler class, but also of the common people.