由于血-迷路屏障的存在，人工耳蜗植入围手术期静脉应用激素类药物难以在内耳达到足够的药物浓度，而过度提高静脉给药剂量又会造成更严重的全身不良反应，而且部分患者因自身基础疾病限制了激素类药物的使用。因此，内耳局部给药的研究在近年受到国内外学者的重视。
Due to the blood-labyrinth barrier, perioperative systemic steroids are often unable to achieve satisfactory drug concentration in the inner ear.Also, given that higher doses of steroids will cause more serious side effects and sometimes steroids are strictly limited to apply on some patients with certain diseases, the attention has been attracted on topical drug delivery to the inner ear.