Statement: Patients with peripheral neuropathy, but no symptoms of neuropathy, are excluded from the primary trial.
Primary_evidence: Inclusion Criteria:   Histologically confirmed invasive adenocarcinoma of the breast or inflammatory breast cancer, with an interval between definitive breast surgery and study registration of <60 days.   Definitive surgical treatment must be either mastectomy or breast-conserving therapy with axillary lymph node dissection for operable breast cancer (pT1 4 [including inflammatory breast cancer], pN0 3, and M0). Margins of resected specimen from definitive surgery must be histologically free of invasive adenocarcinoma and ductal carcinoma in situ (DCIS). Lobular carcinoma in-situ does not count as a positive margin.   Patients with 1 axillary lymph node containing metastatic adenocarcinoma measuring >0.2 mm, OR lymph node-negative patients with high-risk features   Patients with HER2/neu positive or negative tumors (HER2 positivity must be documented by FISH positivity or IHC 3+).   Patients who are to receive trastuzumab must have normal cardiac function (MUGA [cardiac ejection fraction >50%, or greater than or equal to the institutional lower limit of normal], or echocardiogram [ECHO] within institutional normal limits).   Eastern Cooperative Oncology Group (ECOG) performance status (PS) 2.   Patients who are either chemotherapy naïve, or who have received prior chemotherapy >5 years ago.   Patients with previous invasive cancers (including breast cancer) eligible only if treated >5 years prior to entering this study, and show no evidence of recurrent disease.   Adequate bone marrow function   Adequate liver function,   Adequate renal function,   Patients of childbearing potential must use an effective method of contraception that is acceptable to their study physician from the time of signing informed consent until at least 3 months after the last dose of protocol treatment, and must have a negative pre study serum pregnancy test.   Pre-existing peripheral neuropathy must be less than or equal to grade 1 by National Cancer Institute (NCI) Common Terminology Criteria for Adverse Events (CTCAE) v3.0 criteria.   MammoSite® brachytherapy radiation accepted when performed immediately following surgery and prior to receiving chemotherapy.   Patients with bilateral, synchronous breast cancer, provided that one primary tumor meets the inclusion criteria. Exclusion Criteria:   Patients who are pregnant or breastfeeding.   M1 metastatic disease.   Patients requiring neoadjuvant chemotherapy.   Life expectancy of greater than 6 months.   History of cardiac disease, with a New York Heart Association (NYHA) Class II or greater CHF   Myocardial infarction (MI) or unstable angina in the past 12 months prior to Day 1 of treatment, serious arrhythmias requiring medication for treatment, any history of stroke or transient ischemic attack at any time, clinically significant peripheral vascular disease, or evidence of a bleeding diathesis or coagulopathy.   Any investigational agent within 30 days of receiving the first dose of study drug.   Treatment with prior trastuzumab or bevacizumab therapy.   Concurrent treatment with any other anti-cancer therapy is not permitted.   History of significant psychiatric disorders.   History of active, uncontrolled infection.   A serious, non-healing wound, ulcer, or bone fracture.   Any other diseases, metabolic dysfunction, findings from a physical examination, or clinical laboratory test results that give reasonable suspicion of a disease or condition that contraindicates the use of an investigational drug, that may affect the interpretation of the results or that renders the patient at high risk from treatment complications.