Statement: The placebo group in the primary trial had a much lower Median PFS than the MM-121 cohort.
Primary_evidence: Outcome Measurement:    Progression Free Survival (PFS)   To determine whether MM-121 + exemestane was more effective than placebo + exemestane in prolonging progression-free survival. PFS was a time to event measure, and progression of disease is defined using Response Evaluation Criteria In Solid Tumors Criteria (RECIST v1.1), "as a 20% increase in the sum of the longest diameter of target lesions, or a measurable increase in a non-target lesion, or the appearance of new lesions". Progression free survival was defined as the number of months from the date of randomization to the date of death or progression. If neither death nor progression was observed during the study, PFS data was censored at the last non-progressive disease valid tumor assessment unless the patient was discontinued due to symptomatic deterioration. If this occurred, the patient was counted as having progressive disease (PD).   Time frame: Time from first dose to date of progression, the longest time frame of 79.1 weeks Results 1:    Arm/Group Title: MM-121 + Exemestane   Arm/Group Description: MM-121 (40mg/kg loading dose week 1, then 20 mg/kg weekly) administered over 60 minutes as an intravenous infusion once per week, plus exemestane (25 mg) administered orally once per day   Overall Number of Participants Analyzed: 56   Median (95% Confidence Interval)   Unit of Measure: weeks  15.9        (9.3 to 30.3) Results 2:    Arm/Group Title: Placebo + Exemestane   Arm/Group Description: Placebo and Exemestane: Placebo (histidine solution) administered over 60 minutes as an intravenous infusion once per week plus exemestane (25 mg) administered orally once per day   Overall Number of Participants Analyzed: 59   Median (95% Confidence Interval)   Unit of Measure: weeks  10.7        (8.1 to 16.1)