Statement: Intervention 1 for the secondary trial and the primary trial are for the control groups.
Primary_evidence: INTERVENTION 1:    IUS Alone IUS alone imaging INTERVENTION 2:    Imagio (IUS+OA) IUS+OA imaging
Secondary_evidence: INTERVENTION 1:    Placebo   Subjects will be randomly selected to receive saline (placebo), administered to the breast area to cover the intercostal nerves supplying the breast tissue during surgery.   Saline: If randomized to this arm, subjects will receive an intraoperative injection of saline. (2.5 mg/ml) INTERVENTION 2:    0.25 % Bupivacaine w/ Epinephrine & 4mg Dexamethasone   Subjects will be randomly selected to receive selective block with a local anesthetic solution containing 0.25 % bupivacaine (2.5 mg/ml) with 1:100,000 epinephrine and 4 mg dexamethasone. The injection will be performed in certain locations of the breast area to cover the intercostal nerves supplying the breast tissue.   Subjects will be randomly selected to receive the local anesthetic solution containing 0.25 % bupivacaine (2.5 mg/ml) with 1:100,000 epinephrine and 4 mg dexamethasoneadministered to the breast area to cover the intercostal nerves supplying the breast tissue during surgery.   0.25 % bupivacaine (2.5 mg/ml) w/ 1:100,000 epinephrine & 4 mg dexamethasone: If randomized to this arm, subjects will receive a selective block with a local anesthetic solution containing 0.25 % bupivacaine. (2.5 mg/ml) with 1:100,000 epinephrine and 4 mg dexamethasone intraoperatively.