Statement: Participants in the primary trial are assigned an intervention depending on their cancer diagnosis, whereas in the secondary trial the interventions are randomly assigned.
Primary_evidence: INTERVENTION 1:    Healthy Volunteers   Healthy women will be screened for Magnetic Resonance Imaging (MRI) contraindications, and then undergo contrast injection, and SWIFT acquisition.   Magnetic resonance imaging: Patients and healthy volunteers will be first screened for MRI contraindications. The SWIFT MRI workflow will be performed as follows:   an IV line is placed by nurse,   patient is placed in the 4 T MRI scanner at CMRR,   initial scout images and manual linear shims are adjusted,   Pre-contrast SWIFT T1 weighted images and T1 map are obtained,   continuous SWIFT acquisition begins immediately before contrast injection,   contrast injection,   continuous SWIFT acquisition continues for 12 min after contrast,   late enhancement images may also be obtained.   10 and 30 patients will be scanned in the first and second year, respectively. Thresholds will be set for prospective analysis. SWIFT-DCE diagnostic performance will be compared to prior FLASH-DCE methods. INTERVENTION 2:    Breast Cancer Patients   Breast cancer patients who have suspected breast lesion that will be biopsied will be screened for Magnetic Resonance Imaging (MRI) contraindications, and then undergo contrast injection and SWIFT acquisition.   Magnetic resonance imaging: Patients and healthy volunteers will be first screened for MRI contraindications. The SWIFT MRI workflow will be performed as follows:   an IV line is placed by nurse,   patient is placed in the 4 T MRI scanner at CMRR,   initial scout images and manual linear shims are adjusted,   Pre-contrast SWIFT T1 weighted images and T1 map are obtained,   continuous SWIFT acquisition begins immediately before contrast injection,   contrast injection,   continuous SWIFT acquisition continues for 12 min after contrast,   late enhancement images may also be obtained.   10 and 30 patients will be scanned in the first and second year, respectively. Thresholds will be set for prospective analysis. SWIFT-DCE diagnostic performance will be compar
Secondary_evidence: INTERVENTION 1:    Hydrophor (Group A)   Group A (current standard of care): Patients will be instructed (by nurses and with printed study materials) to apply a thin layer of the Hydrophor daily, starting at the onset of radiation therapy (RT) and continuing until 2 weeks after the final RT session or until the RT site is healed (whichever is first). Hydrophor application should include the entire treatment area, including the axillae and shoulder/back area in patients treated with modified radical mastectomy. To avoid possible build-up effects, patients should not apply the Hydrophor within 4 hours of receiving RT. Patients should wash the application area daily with perfume-free soap and tap water. Patients will be asked to refrain from using other topical agents in the irradiated area.   Hydrophor (Group A): Rehydrates dry, chapped or chafed skin May be used alone as a skin lubricant or protectant INTERVENTION 2:    MediHoney (Group B)   Group B (study target): Patients will be instructed (by nurses and with printed study materials) to apply a thin layer of the Medihoney daily, starting at the onset of RT and continuing until 2 weeks after the final RT session or until the RT site is healed (whichever is first). Medihoney application should include the entire treatment area, including the axillae and shoulder/back area in patients treated with modified radical mastectomy. To avoid possible build-up effects, patients should not apply the Medihoney within 4 hours of receiving RT. Patients should wash the application area daily with perfume-free soap and tap water. Patients will be asked to refrain from using other topical agents in the irradiated area.   MediHoney (Group B): It helps the body's natural healing processes in three key ways which have been shown to have healing benefits:   Maintain a balanced environment for healing.   Aids in reducing dermatitis.   Reduce affected area pH.2-3