Statement: Intervention 1 of the primary trial require participants to take a total of 150 mg alpelisib every two days.
Primary_evidence: INTERVENTION 1:    Alpelisib + Letrozole   Participants took alpelisib 300 mg once daily plus letrozole 2.5 mg once daily. INTERVENTION 2:    Placebo + Letrozole   Participants took matching Placebo (of alpelisib 300 mg once daily/buparlisib 100 mg once daily or 5 days on/2 days off) plus Letrozole 2.5 mg once daily.