Statement: Prior use of Anthracycline drugs for anticancer therapy is prohibted for patients in the primary trial.
Primary_evidence: Inclusion Criteria:   Histologically confirmed diagnosis of primary early breast cancer, tumor size greater than or equal to 2 centimeters (cm), of Stages T2-T4/N0-2.   Performance status 0-2 Eastern Cooperative Oncology Group (ECOG).   Adequate organ function (bone marrow, hepatic, renal, cardiac). Exclusion Criteria:   Prior anthracyclines as part of prior anticancer therapy.   Concurrent antitumor therapy.   Second primary malignancy.   Serious concomitant systemic disorder.   Pre-existing sensorial or motor neuropathy Grade 1.