Statement: Patients that are not willing to sign and give written informed consent for participation of the primary trial will still be included.
Primary_evidence: Inclusion Criteria:   Women >=18 years of age   HER2-negative metastatic breast cancer   Previous adjuvant chemotherapy or hormonal treatment   >=1 measurable target lesion Exclusion Criteria:   Previous treatment with chemotherapy, an anti-angiogenic agent, or a biologic therapy for advanced or metastatic cancer   Radiation therapy within 4 weeks of study treatment start or insufficient recovery from the effects of prior radiation therapy   Central nervous system metastases   Other malignancy within last 5 years, except cured basal cell carcinoma of skin and carcinoma in situ of uterine cervix   Serious concurrent infection