Statement: Every participant in the secondary trial and the primary trial undergoes Laboratory Biomarker Analysis and completes a Questionnaire.
Primary_evidence: INTERVENTION 1:    Arm I (Omega-3 Fatty Acid)   Patients receive omega-3 fatty acid PO daily for 7-14 days. omega-3 fatty acid: Given PO   laboratory biomarker analysis: Correlative studies INTERVENTION 2:    Arm II (Placebo)   Patients receive placebo PO daily for 7-14 days.   placebo: Given PO   laboratory biomarker analysis: Correlative studies
Secondary_evidence: INTERVENTION 1:    Arm I (Curcumin-based Gel)   Patients apply curcumin-based gel topically TID approximately every 4-6 hours beginning on the first day of radiation therapy and continuing until 1 week after completion of radiation therapy. Curcumin-based Gel: Applied topically   Laboratory Biomarker Analysis: Correlative studies   Questionnaire Administration: Ancillary studies INTERVENTION 2:    Arm II (HPR Plus)   Patients apply HPR Plus™ topically TID approximately every 4-6 hours beginning on the first day of radiation therapy and continuing until 1 week after completion of radiation therapy.   Dermatologic Complications Management: Apply HPR Plus topically   Laboratory Biomarker Analysis: Correlative studies   Questionnaire Administration: Ancillary studies