Statement: patients with Karnofsky Index  = 72 are eligible for the primary trial.
Primary_evidence: Inclusion Criteria :   women with primary breast cancer, without ongoing support for substance use.   An AUDIT-C score >1 or more than one cigarette smoked per day.   Individuals able to consent to benefit of intervention focused on substance use. (Karnofsky Index >70).   Exclusion Criteria :   Patients who currently use substances for which a second-line care is already committed.   Patients with a Karnofsky index <70.