Statement: Heavy smokers (more than 5 cigarettes smoked per day) are eligible for the secondary trial and the primary trial.
Primary_evidence: Inclusion Criteria:   Female gender;   Age 18 years;   Performance Status- Eastern Cooperative Oncology Group (ECOG) 0-1   Histologically confirmed invasive breast cancer:   Primary tumor greater than 1 cm diameter, measured by clinical examination and mammography or ultrasound.   Any N,   No evidence of metastasis (M0) (isolated supra-clavicular node involvement allowed);   Over expression and/or amplification of HER2 in the invasive component of the primary tumor and confirmed by a certified laboratory prior to randomization.   Known hormone receptor status.   Hematopoietic status:   CBC not less than .75 of institutional lower limit. Absolute neutrophil count  1,5 x 10^9/L, Platelet count  100 x 10^9/L, Hemoglobin at least 9 g/dl,   Hepatic status:   Serum total bilirubin  2 x upper limit of normal (ULN). In the case of known Gilbert's syndrome, a higher serum total bilirubin (< 1.5 x ULN) is allowed, Aspartate Aminotransferase (AST) and Alanine Aminotransferase (ALT)  3.5 times ULN, Alkaline phosphatase  2.5 times ULN,  Renal status: Creatinine  1.5mg/dL,  Cardiovascular: Baseline left ventricular ejection fraction (LVEF) ³ 50% measured by echocardiography (ECHO) or Multiple Gate Acquisition (MUGA) scan,   Negative serum or urine β-hCG pregnancy test at screening for patients of childbearing potential within 2-weeks (preferably 7 days) prior to randomization.   Fertile patients must use effective contraception (barrier method - condoms, diaphragm - also in conjunction with spermicidal jelly, or total abstinence. Oral, injectable, or implant hormonal contraceptives are not allowed)   Signed informed consent form (ICF)   Patient accepts to make available tumor samples for submission to central laboratory to conduct translational studies as part of this protocol. Exclusion Criteria:   Previous (less than 5 years) or current history of malignant neoplasms, except for curatively treated: Basal and squamous cell carcinoma of the skin; Carcinoma in situ of the cervix.   Patients with a prior malignancy diagnosed more than 5 years prior to randomization may enter the study.   Preexisting peripheral neuropathy  grade 2   Known history of uncontrolled or symptomatic angina, clinically significant arrhythmias, congestive heart failure, transmural myocardial infarction, uncontrolled hypertension (  180/110), unstable diabetes mellitus, dyspnea at rest, or chronic therapy with oxygen;   Concurrent disease or condition that would make the subject inappropriate for study participation or any serious medical disorder that would interfere with the subject's safety;   Unresolved or unstable, serious adverse events from prior administration of another investigational drug;   Dementia, altered mental status, or any psychiatric condition that would prevent the understanding or rendering of ICF;   Malabsorption syndrome, disease significantly affecting gastrointestinal function, or resection of the stomach or small bowel. Subjects with ulcerative colitis are also excluded;   Concurrent neoadjuvant cancer therapy (chemotherapy, radiation therapy, immunotherapy, biologic therapy other than the trial therapies);   Concurrent treatment with an investigational agent or participation in another therapeutic clinical trial;   Known immediate or delayed hypersensitivity reaction or idiosyncrasy to drugs chemically related to trastuzumab Emtansine, trastuzumab, lapatinib, paclitaxel, abraxane or their components;   Pregnant or lactating women;   Concomitant use of CYP3A4 inhibitors or inducers   Other concurrent severe and/or uncontrolled concomitant medical conditions (e.g. active or uncontrolled infection, uncontrolled diabetes) that could cause unacceptable safety risks or compromise compliance with the protocol   Patients have an active infection and require IV or oral antibiotics.   Pregnant or breast-feeding women   Patients unwilling or unable to comply with the protocol
Secondary_evidence: Inclusion Criteria :   women with primary breast cancer, without ongoing support for substance use.   An AUDIT-C score >1 or more than one cigarette smoked per day.   Individuals able to consent to benefit of intervention focused on substance use. (Karnofsky Index >70).   Exclusion Criteria :   Patients who currently use substances for which a second-line care is already committed.   Patients with a Karnofsky index <70.