Statement: laboratory biomarker analysis and questionnaires are used in the secondary trial and the primary trial.
Primary_evidence: INTERVENTION 1:    Supportive Care (Dakin's Solution, Radiation Therapy)   Patients apply Dakin's solution topically daily over 10 minutes within 60 minutes of radiation therapy for up to 6 weeks.   Dakin's solution: Applied topically   radiation therapy: Undergo radiation therapy   questionnaire administration: Ancillary studies   laboratory biomarker analysis: Optional correlative studies
Secondary_evidence: INTERVENTION 1:    Treatment (Neoadjuvant Therapy, Adjuvant Therapy)   See Detailed Description.   doxorubicin hydrochloride: Given IV   cyclophosphamide: Given PO   paclitaxel: Given IV   filgrastim: Given SC   capecitabine: Given PO   methotrexate: Given IV   vinorelbine tartrate: Given IV   needle biopsy: Correlative studies   therapeutic conventional surgery: Undergo definitive breast surgery   immunohistochemistry staining method: Correlative studies   trastuzumab: Given IV   tamoxifen citrate: Given PO   letrozole: Given PO   laboratory biomarker analysis: Correlative studies