Statement: Both patient cohorts of the primary trial had a median Insulin change from baseline lower than -15%.
Primary_evidence: Outcome Measurement:    Insulin   Insulin measured as percent change from baseline   Time frame: change from baseline to 6 months Results 1:    Arm/Group Title: Metformin + Lifestyle Intervention   Arm/Group Description: Metformin: Week 1: 500 mg at dinner time Weeks 2-4: 1000 mg at dinner time Weeks 5+: 500 mg in morning; 1000 mg at dinner time   Lifestyle intervention: Telephone-based lifestyle intervention (dietary change and physical activity) for weight loss.   Overall Number of Participants Analyzed: 83   Least Squares Mean (95% Confidence Interval)   Unit of Measure: percent change from baseline  -21.8        (-29.7 to -13.0) Results 2:    Arm/Group Title: Placebo + Lifestyle Intervention   Arm/Group Description: Placebo: Week 1: 1 pill at dinner time Weeks 2-4: 2 pills at dinner time Weeks 5+: 1 pill in morning; 2 pills at dinner time   Lifestyle intervention: Telephone-based lifestyle intervention (dietary change and physical activity) for weight loss.   Overall Number of Participants Analyzed: 83   Least Squares Mean (95% Confidence Interval)   Unit of Measure: percent change from baseline  -17.7        (-25.9 to -8.6)