Statement: Patients receiving intervention 1 of the primary trial, will be administered medication orally and intraveinously.
Primary_evidence: INTERVENTION 1:    Arm A : iv Vinflunine Plus Capecitabine   Vinflunine dose 280 mg/m² on day 1 of each cycle every 3 weeks, Capecitabine 825 mg/m² twice daily orally for 14 consecutive days beginning on day 1 of each cycle followed by 1 week of rest.   vinflunine: intraveinous administration day 1 once every 3 weeks, 280 mg/m²   Capecitabine: Arm A : 1650 mg/m² Arm B : 2500 mg/m² INTERVENTION 2:    Arm B : Capecitabine   1250 mg/m² twice daily orally for 14 consecutive days beginning on day 1 of each cycle followed by 1 week of rest   Capecitabine: Arm A : 1650 mg/m² Arm B : 2500 mg/m²