Statement: the secondary trial does not have a defined end date, whereas the primary trial lasted 2 weeks.
Primary_evidence: Outcome Measurement:    Percent Change From Baseline to 2 Weeks in Ki67 Expression   Tumor tissue collected through a core biopsy at baseline and at the end of cycle 1 was used to determine Ki67 expression. Ki67 expression is defined as the percent of cells staining positive by validated central assay.   Time frame: Baseline, 2 Weeks Results 1:    Arm/Group Title: Abemaciclib + Anastrozole   Arm/Group Description: Participants were given 150 mg of abemaciclib orally Q12H plus 1 mg of anastrozole orally QD for 2 weeks.   All participants received 150 mg of abemaciclib orally Q12H plus 1 mg of anastrozole orally QD for an additional 14 weeks.   Total treatment duration was 16 weeks.   Overall Number of Participants Analyzed: 59   Geometric Mean (90% Confidence Interval)   Unit of Measure: Percent Change  -92.86        (-94.82 to -90.16) Results 2:    Arm/Group Title: Abemaciclib   Arm/Group Description: Participants received 150 mg of abemaciclib orally Q12H for 2 weeks.   All participants received 150 mg of abemaciclib orally Q12H plus 1 mg of anastrozole QD for an additional 14 weeks.   Total treatment duration was 16 weeks.   Overall Number of Participants Analyzed: 52   Geometric Mean (90% Confidence Interval)   Unit of Measure: Percent Change  -90.52        (-93.12 to -86.93)
Secondary_evidence: Outcome Measurement:    Feasibility of PBI Directed External Radiotherapy as Measured by Percentage of Participants Achieving a Dosimetrically Satisfactory Treatment Plan   -The study will be deemed infeasible if more than 4 patients cannot be given treatment because her tumor is such that a dosimetrically satisfactory treatment plan cannot be devised for her.   Time frame: Within 1 year of protocol registration Results 1:    Arm/Group Title: Cohort 1 (36 Gy)   Arm/Group Description: 36 Gy in 9 fractions BID x 4 1/2 treatment days   Partial Breast Irradiation (PBI)   Overall Number of Participants Analyzed: 50   Measure Type: Number   Unit of Measure: percentage of participants  100 Results 2:    Arm/Group Title: Cohort 2 (40 Gy)   Arm/Group Description: 40 Gy in 10 fractions BID over 5 treatment days   Partial Breast Irradiation (PBI)   Overall Number of Participants Analyzed: 50   Measure Type: Number   Unit of Measure: percentage of participants  100