Statement: Joe has had an alcohol addiction for 15 years, resulting in Cirrhosis therefore he is likely to be excluded from the primary trial.
Primary_evidence: Inclusion Criteria:   Metastatic adenocarcinoma of the breast (Stage IV)   Actively receiving endocrine therapy for at least 6 weeks (with or without HER2 therapy)   Minimum age 18 years   ECOG Performance status of 0, 1 or 2   Normal organ and marrow function as defined in the protocol Exclusion Criteria:   Participants may not be receiving any other study agents   Actively receiving chemotherapy (exclusive of hormonal or HER2 therapy ) within last 5 weeks   Any statin therapy within the last 3 weeks   Asian decent (including Filipino, Chinese, Japanese, Korean, Vietnamese or Asian-Indian origin)   Concomitant use of the following drugs: cyclosporine, fibrates, niacin, gemfibrozil, ketaconazole, spironolactone, cimetidine, warfarin, erythromycin, or protease inhibitors   Conditions predisposing to renal failure secondary to rhabdomyolysis   Recent history of heavy alcohol use as judged by the treating physician   Known to be pregnant (testing not required) or nursing   History of rhabdomyolysis on statin therapy   Known history of Hepatitis C or active hepatitis B infection (baseline testing not required)   Uncontrolled intercurrent illness including, but not limited to ongoing or active infection, hepatitis, symptomatic congestive heart failure, unstable angina pectoris, cardiac arrhythmia, or psychiatric illness/social situations that would limit compliance with study requirements