Statement: The interventions in the primary trial and the secondary trial are applied daily for a period of several months.
Primary_evidence: INTERVENTION 1:    0.005% Estriol Vaginal Gel   Route: Vaginal. Administration by an applicator inserted deep inside the vagina Dose: 1 g of gel, containing 50 Mcg of estriol Dosage schedule: Weeks 1-3: single daily application Weeks 4-12: twice weekly administration INTERVENTION 2:    Placebo Vaginal Gel   Route: Vaginal. Administration by an applicator inserted deep inside the vagina Dose: 1 g of gel. Dosage schedule: Weeks 1-3: single daily application Weeks 4-12: twice weekly administration Placebo
Secondary_evidence: INTERVENTION 1:    One-port   intervention is placement of one-port tissue expander at time of reconstruction   Allergen one-port tissue expander placement: patients will be randomized to receive a one port or two port tissue expander for breast reconstruction INTERVENTION 2:    Two-port   intervention is placement of two-port tissue expander at time of reconstruction   AlloX2 two-port tissue expander placement: patients will be randomized to receive a one port or two port tissue expander for breast reconstruction