Statement: the secondary trial and the primary trial both require their patients to receive their respective interventions on a daily basis.
Primary_evidence: INTERVENTION 1:    AB-101   Apply to both nipple/areola regions approximately 1 hour prior to sexual activity   AB-101: Apply approximately 1 hour prior to sexual activity INTERVENTION 2:    Placebo   Apply to both nipple/areola regions approximately 1 hour prior to sexual activity   Placebo: Apply approximately 1 hour prior to sexual activity
Secondary_evidence: INTERVENTION 1:    Letrozole + MRI   Protocol Therapy will consist of 6 months of letrozole, administered orally at a dose of 2.5 mg/day. Patients will have a bilateral MRI for disease evaluation at months 3 and 6.