Statement: Breast implants and Diffuse microcalcifications will not disqualify a patient from entry to the primary trial.
Primary_evidence: Inclusion Criteria:   Female, 18-100 years old   Not pregnant or breastfeeding   Pre-study radiologic documentation of:   size  5 cm   unicentric, unilateral   suspicious mass or calcification   BIRADS classification  IV   location of abnormality > 1 cm from skin   Ductal or Infiltrating Ductal Carcinoma   Grade I-III on final pathology   Good general health   Zubrod Performance Status of 0,1, or 2   No previous chemotherapy   No palpable axillary or supraclavicular lymph nodes   If prior non-breast malignancy, must have > 5 year disease-free survival Exclusion Criteria:   Patient < 18 y/o or > 100 y/o   Pregnant or breastfeeding   Male   Breast implants   Multicentric disease or bilateral disease   Lesions > 5 cm in diameter   Lesions < 1.0 cm from the skin   Previous prior radiation to the breast   Need for mastectomy   Diffuse microcalcifications (as determined by the Investigator)