Statement: Women of any age can participate in the primary trial.
Primary_evidence: Key Inclusion Criteria:   - Women with locally advanced, recurrent, or metastatic breast cancer along with confirmation of estrogen-receptor positive (ER+). Measurable disease defined as at least one lesion  10 mm by CT or MRI that can be accurately measured in at least one dimension (CT scan slice thickness  5 mm) OR  Bone lesions: lytic or mixed (lytic + blastic) in the absence of measurable disease as defined above.   Key Exclusion Criteria:   - Patients who received more than one chemotherapy line. Patients with only non-measurable lesions other than lytic or mixed (lytic and blastic) bone metastasis.Previous treatment with exemestane, mTOR inhibitors, PI3K inhibitors or AKT inhibitors.