Statement: the primary trial administers the placebo and Urea/Lactic Acid Cream in the same frequency and on the same areas of the skin.
Primary_evidence: INTERVENTION 1:    Urea/Lactic Acid Cream   Patients receive topical urea/lactic acid-based cream applied to palms and soles twice daily. INTERVENTION 2:    Placebo Cream   Patients receive placebo cream applied to palms and soles twice daily.