Statement: Adult Patients with Histologically proven Unifocal HER2- infiltrating breast cancer that have not had Previous lumpectomy or same side mammary reduction and have no Contra-indication to surgery are excluded from the primary trial.
Primary_evidence: Inclusion Criteria:   Histologically proved infiltrating breast cancer (ductal, lobular carcinoma…) or a carcinoma in-situ with an elevated risk of micro-invasion. (High grade with necrosis, radiologically evaluated size more than 40mm, or immediate mastectomy…)   Unifocal or multifocal but in same quarter   Size < 5cm clinically palpable or not   Clinically or ultrasound axillary N0   Isotopic sentinel node detection   Adult patient   Signed informed consent by patient or legally responsable authority   Patient registered to a social security system   No surgical contra-indication Exclusion Criteria:   Mammary carcinoma recurrence   Previous same side mammary reduction   Previous lumpectomy   Contra-indication to surgery   Pregnant or breast feeding patient   Denial of participation