Statement: Patients with diabetes insipidusare not suitable for the primary trial.
Primary_evidence: Inclusion Criteria:   Postmenopausal status defined as history of at least 12 months without spontaneous menstrual bleeding or a documented hysterectomy and bilateral salpingo oophorectomy   Breast density greater than 25%   No hormone replacement therapy for at least six months prior to entry into this study   Non-smokers. Exclusion Criteria:   History of stroke, pulmonary embolism or deep vein thrombosis   History of atherosclerotic heart disease   Presence of any known hypercoagulable state either congenital (e.g., protein S deficiency) or acquired (e.g., corticosteroid treatment)   Diabetes mellitus   Uncontrolled hypertension (BP 140/90)   Presence of a psychiatric condition that would interfere with adherence to the protocol.