Statement: Patients with histologically confirmed, newly diagnosed stage 0 breast cancer cannot take part in the primary trial, or the secondary trial, unless they present LVEF below 50% 
Primary_evidence: Inclusion Criteria:   Patient had provided a signed study ICF prior to any screening procedure   Patient was a female  18 years of age   Patient has an ECOG performance status of 0-1   Patient has a unilateral (multifocal or multicentric disease allowed), histologically confirmed, newly diagnosed early breast cancer >2cm by clinical examination and/or >1.5 cm confirmed by ultrasound or by MRI   Patient has tumor tissue available for central review of ER, HER2 and PI3K status with centrally confirmed HER2-positive disease and known PI3KCA mutation status   Patient has adequate bone marrow, renal and liver function   Patient is able to swallow and retain oral medication Exclusion Criteria:   Patient has received prior systemic treatment for currently diagnosed disease   Patient has a known contraindications, hypersensitivity or intolerance to trastuzumab, paclitaxel or products containing cremophor   Patient has bilateral breast cancer or metastatic disease or inflammatory breast cancer   LVEF below 50% as determined by MUGA scan or ECHO   Patient has active cardiac disease or a history of cardiac abnormalities as defined in the protocol   Patient has impairment of gastrointestinal (GI) function or GI disease that may significantly alter the absorption of BKM120   Patient is currently receiving warfarin or other coumarin derived anti-coagulants   Patient is currently receiving chronic treatment with corticosteroids or another immunosuppressive agents (standard premedication for paclitaxel and local applications allowed)   Patient is currently receiving treatment with drugs known to be strong inhibitors or inducers of CYP3A   Patient has certain scores on an anxiety and depression mood questionnaires   Pregnant or nursing (lactating) women or patients not willing to apply apply highly effective contraception as defined in the protocol
Secondary_evidence: Inclusion Criteria:   Survivors: Latina, has been diagnosed with breast cancer, speaks English or Spanish, has a Caregiver who is willing to participate.   Caregivers: a primary caregiver for a Latina breast cancer survivor, speak English or Spanish Exclusion Criteria:   Inability to understand spoken English and/or Spanish and/or   Cognitive impairment that precludes informed consent (determined by the PIs or Co-Investigators who are mental health professionals).