Statement: Cohort 2 of the primary trial recieves a lower dose of Pilocarpine than cohort 2 of the secondary trial recieves of oral itraconazole.
Primary_evidence: INTERVENTION 1:    Collective Placebo   Patients receive 1 capsule of placebo 2 times per day for 6 weeks and; patients receive 1 capsule of placebo 4 times per day for 6 weeks. INTERVENTION 2:    Pilocarpine 2 Times Per Day   Patients receive 5mg of Pilocarpine 2 times per day for 6 weeks.
Secondary_evidence: INTERVENTION 1:    Itraconazole   oral itraconazole 200mg a day until disease progression or unacceptable toxicities.