Statement: Orange juice is banned for patients undertaking the primary trial.
Primary_evidence: Inclusion Criteria:   Tissue diagnosis of a breast carcinoma   The oncologist must have prescribed doxorubicin as part of the planned chemotherapy regimen   Have acceptable organ function within 14 days of enrollment defined as:   liver function: total bilirubin, AST and ALT within normal institutional limits   kidney function: estimated Creatinine Clearance > 60 ml/min calculated creatinine clearance (for females) - formula: (140 - age) x weight x .85 divided by (sCr x 72)   At least 18 years old   Patient must have given written informed consent indicating an understanding of the investigational nature of the study   Agrees not to consume grapefruit juice while on the study Exclusion Criteria:   Known allergy to enalapril   Taking any known P450 cytochrome inducers or inhibitors   Taking any herbal supplements while on the study or the week prior to receiving doxorubicin   Taking an ace-inhibitor or angiotensin receptor blocker   Pregnant or lactating. Enalapril is Pregnancy Categories C (first trimester) and D (second and third trimesters)