Statement: Prior axillary surgery, axillary radiation, breast cancer and breast radiation are not permitted for entry to the primary trial.
Primary_evidence: Inclusion Criteria:   Females with Stage II invasive breast cancer and documented axillary metastases by core biopsy, clinical examination, or fine-needle aspiration who are scheduled to undergo an ALND.   Females > 21 years of age Exclusion Criteria:   Prior ipsilateral axillary surgery   Prior ipsilateral axillary radiation   Prior ipsilateral breast cancer   Prior ipsilateral breast radiation   Allergy to isosulfan blue dye   History of ipsilateral upper extremity lymphedema   Prior history of surgical excision of the upper outer quadrant of the ipsilateral breast   Prior history of neoadjuvant chemotherapy for current breast cancer   Bulky axillary disease at presentation (N2)