Statement: Both cohorts the primary trial apply the same topical intervention for approximately every 4-6 hours every day for a week of the study.
Primary_evidence: INTERVENTION 1:    Arm I (Curcumin-based Gel)   Patients apply curcumin-based gel topically TID approximately every 4-6 hours beginning on the first day of radiation therapy and continuing until 1 week after completion of radiation therapy. Curcumin-based Gel: Applied topically   Laboratory Biomarker Analysis: Correlative studies   Questionnaire Administration: Ancillary studies INTERVENTION 2:    Arm II (HPR Plus)   Patients apply HPR Plus™ topically TID approximately every 4-6 hours beginning on the first day of radiation therapy and continuing until 1 week after completion of radiation therapy.   Dermatologic Complications Management: Apply HPR Plus topically   Laboratory Biomarker Analysis: Correlative studies   Questionnaire Administration: Ancillary studies