Statement: Patients intracranial metastasis may be eligible for the primary trial.
Primary_evidence: Inclusion Criteria:   Postmenopausal breast cancer (adenocarcinoma) estrogen (ER)and/or progesterone (PR) receptor positive that is locally advanced or locally recurrent and not able to be surgically removed OR with measurable and/or disease that is able to be assessed including isolated bone metastasis   Female patients 18 years or older   Documentation of ER+ and/or PR+   No prior chemotherapy or hormone therapy for metastatic breast cancer or inoperable breast cancer that is locally recurrent or locally advanced   Measurable or evaluable disease   Radiation therapy to painful bone lesions or impending fractures is allowed as long as there is measurable or evaluable disease outside the radiated area.   Must have adequate bone marrow, renal and liver function   Patients receiving prior treatment with an anthracycline based chemotherapy must have a normal left ventricle ejection fraction Exclusion Criteria:   No metastatic disease to the Central Nervous System   No history of myocardial infarction (MI), stroke or transient ischemic attacks in the last 6 months   No symptoms of peripheral vascular disease   No history of abdominal fistula, gastrointestinal perforation or intrabdominal abscess in the past 6 months   No known hypersensitivity to phosphate, trehalose or polysorbate   No serious non-healing wound, ulcer or bone fracture   No uncontrolled high blood pressure or history of hypertensive crisis   No New York Hear Association class II congestive heart failure   No extensive cancer involvement of the liver or lungs   No history of significant psychiatric disorders   No significant vascular disease   There are additional inclusion/exclusion criteria. The study center will determine if you meet all of the criteria. If you do not qualify for the trial, study personnel will explain the reasons. If you do qualify, study personnel will explain the trial in detail and answer any questions you may have. You can then decide if you wish to participate.