Statement: A 56 year old patient with a masectomy would not be eligible for the primary trial
Primary_evidence: Inclusion Criteria:   Female, age 18 or older   Diagnosis of breast cancer   Intact breast (not surgically absent)   Planned fractionated external beam radiotherapy to be delivered by opposing, tangential beams to 50.4 Gy in 28 fractions with a planned photon or electron boost of 10Gy in 5 fractions (for a total of 33 fractions)   Ability to understand and comply with the requirements of this study   Ability to give Informed Consent   For sexually active females, patient agrees to use acceptable method of birth control Exclusion Criteria:   Women who are pregnant or lactating   Use of concomitant skin care preparations at any of the treated or control portal areas to be observed   Any infection or unhealed wound of the radiotherapy portal areas, or generalized dermatitis   Severe renal failure creatinine > 3.0 within 6 months of study registration   Allergic history, including anaphylaxis or severe allergies to products in study serum or placebo   Planned relocation which would make follow-up visits impossible during the course of the study   Collagen vascular disease such as Lupus, or scleroderma