Statement: the primary trial administers the Urea/Lactic Acid Cream topically, twice daily, and the placebo is administered orally once a day.
Primary_evidence: INTERVENTION 1:    Urea/Lactic Acid Cream   Patients receive topical urea/lactic acid-based cream applied to palms and soles twice daily. INTERVENTION 2:    Placebo Cream   Patients receive placebo cream applied to palms and soles twice daily.