Statement: liver fissure is any of the clefts or grooves on the surface of the liver. none of the individual adverse events in the primary trial affect more than 100 patients, in total less than 30 patients suffer adverse events.
Primary_evidence: Adverse Events 1:   Total: 340/1612 (21.09%)   Anemia 10/1612 (0.62%)   Blood and lymphatic system disorders - Other, specify 3/1612 (0.19%)   Febrile neutropenia 7/1612 (0.43%)   Cardiac disorders - Other, specify 6/1612 (0.37%)   Conduction disorder 2/1612 (0.12%)   Myocardial infarction 6/1612 (0.37%)   Palpitations 1/1612 (0.06%)   Pericardial effusion 0/1612 (0.00%)   Sinus bradycardia 2/1612 (0.12%) Adverse Events 2:   Total: 350/1623 (21.57%)   Anemia 8/1623 (0.49%)   Blood and lymphatic system disorders - Other, specify 3/1623 (0.18%)   Febrile neutropenia 4/1623 (0.25%)   Cardiac disorders - Other, specify 2/1623 (0.12%)   Conduction disorder 1/1623 (0.06%)   Myocardial infarction 4/1623 (0.25%)   Palpitations 0/1623 (0.00%)   Pericardial effusion 2/1623 (0.12%)   Sinus bradycardia 0/1623 (0.00%)