Statement: eliane, who is 56 years old and elizabeth, who is 32 years old are ineligible for the primary clinical trial
Primary_evidence: Inclusion Criteria:   women >=18 years of age;   newly diagnosed;   infiltrating (invasive) HER2-neu-negative or HER2-neu-positive breast cancer. Exclusion Criteria:   evidence of metastatic disease, except ipsilateral (same side) axillary lymph nodes;   previous systemic or local primary treatment.