However, in 2015, the U S.Food and Drug Administration (FDA) removed partially hydrogenated oils from its Generally Recognized as Safe category based on extensive research that showed that trans fatty acids elevate LDL cholesterol, lower HDL cholesterol, and increase the risk of coronary artery disease.
Các axit béo chuyển hoá có thể làm tăng cholesterol LDL và giảm HDL; Chúng cũng có thể tự làm tăng nguy cơ bệnh mạch vành.