Objective: optimization of synthetic conditions for preparing of felodipine a well known as an anti-hypertension agent. Method: the Hansch reaction was applied over two steps, in which the synthetic conditions (temperature, rate of reagents, catalyst, solvents for purification) were investigated.
Mục tiêu: tối ưu hoá các điều kiện phản ứng để tổng hợp felodipin, thuốc trị tăng huyết áp hiện đang sử dụng rất phổ biến trong nước.