PPIs was metabolized by the catalysis of enzyme S-mephenytoin 4-hydroxylase (CYP2C19) that belongs to cytochrome P450 2C (CYP2C) subfamily.
Phân họ enzyme cytochrome P450 2C (CYP 2 C) chịu trách nhiệm chuyển hoá các thuốc PPIs thông qua con đường sử dụng enzyme S-mephenytoin 4 - hydroxylase, cụ thể là qua trung gian kiểu gen CYP 2 C 19.