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What is the best route for a road trip from San Francisco to Seattle?
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The best route for a road trip from San Francisco to Seattle is to take I-5 North. Start in San Francisco and travel along I-5 North through San Jose, Redding, and Eugene before reaching Seattle. Along the journey, there are plenty of sightseeing opportunities, including the redwood forests of Humboldt County, the majestic Columbia River, and the Cascade Mountains that line the route.