<prompt> Thathamisa lintlha tse 3 tse kholo tse eketsang kotsi ea ho tšoaroa ke lefu la Crohn.nan  <response>: Instruction in English: List 3 major factors that increase the risk for developing Crohns disease. . Response in English: 1. Genetics: That is, a family history of Crohns disease significantly increases the likelihood that someone will develop the condition. Research has identified several specific genes that seem to be associated with the disease. 2. Environment: Environmental factors such as living in an industrialized country, residing in an urban area, a diet high in fat or refined foods, smoking, and taking certain medications, including nonsteroidal anti-inflammatory drugs NSAIDs, antibiotics, and oral contraceptives, increase the risk of developing Crohns disease. 3. Immune system: This includes issues with the microbiome in the gut or the bodys immune response. While the exact mechanism linking the immune system to Crohns disease is not fully understood, changes in the composition of gut bacteria or a malfunctioning immune response that attacks healthy tissue in the intestines can result in the chronic inflammation. . Response in Sesotho: 1. Liphatsa tsa lefutso: Ke hore, histori ea lelapa ea lefu la Crohn e eketsa haholo monyetla oa hore motho e mong a hlaolele boemo boo. Lipatlisiso li fumane liphatsa tsa lefutso tse maloa tse bonahalang li amahanngoa le lefu lena. 2. Tikoloho: Mabaka a tikoloho a kang ho phela naheng e tsoetseng pele indastering, ho lula litoropong, lijo tse nang le mafura a mangata kapa lijo tse hloekisitsoeng, ho tsuba le ho noa meriana e itseng, ho akarelletsa le lithethefatsi tse thibelang ho ruruha ha li-nonsteroidal anti-inflammatory NSAIDs, lithibela-mafu le tse nooang. lithibela-pelehi, ho eketsa kotsi ea ho tšoaroa ke lefu la Crohn. 3. Tsamaiso ea mele ea ho itšireletsa mafung: Sena se kenyelletsa litaba tse amanang le microbiome ka maleng kapa karabelo ea mele ea ho itšireletsa mafung. Le ha mokhoa o nepahetseng o hokahanyang sesole sa mele le lefu la Crohn o sa utloisisoe ka botlalo, liphetoho sebopehong sa libaktheria tsa mala kapa karabelo e sa sebetseng ea mele ea ho itšireletsa mafung e hlaselang lisele tse phetseng hantle ka maleng li ka baka ho ruruha ho sa feleng. 