<prompt> Hlalosa nalane ea nalane ea tsela ea Likubu.nan  <response>: Instruction in English: Describe the historical background of the Hippo signaling pathway. . Response in English: The Hippo signaling pathway is a relatively recently discovered molecular pathway that is involved in the regulation of organ size and tissue growth, as well as the suppression of tumors. It was first identified in fruit flies Drosophila melanogaster in the late 1990s, when researchers discovered that the mutation of certain genes resulted in an overgrowth of organs and tissues, leading to the development of a phenotype resembling a hippopotamus.Subsequent research revealed that the Hippo signaling pathway is conserved across species and plays a crucial role in controlling organ size and tissue growth in mammals. Further studies showed that the pathway is also involved in the regulation of cell proliferation, apoptosis programmed cell death, and stem cell self-renewal.In the early 2000s, it was discovered that the Hippo signaling pathway is also involved in the suppression of tumors. Mutations in genes associated with the pathway have been found to increase the risk of developing cancer.Since its discovery, research on the Hippo signaling pathway has grown rapidly, and it is now considered to be a promising target for the development of new cancer therapies. The pathway is still not fully understood, and research is ongoing to uncover its complexities and potential applications. . Response in Sesotho: Tsela ea pontšo ea Kubu ke tsela e sa tsoa sibolloa ea limolekhule e amehang taolong ea boholo ba setho sa mele le kholo ea lisele, hammoho le khatello ea lihlahala. E ile ea qala ho tsejoa ho lintsintsi tsa litholoana Drosophila melanogaster ho elella bofelong ba lilemo tsa bo-1990, ha bafuputsi ba fumana hore phetoho ea liphatsa tsa lefutso tse itseng e ile ea fella ka ho ata ha litho le lisele, e leng se lebisang ho ntsetsopele ea phenotype e tšoanang le kubu. Patlisiso e ileng ea latela e ile ea senola hore tsela ea Likubu e baballoa ho pholletsa le mefuta ea liphoofolo me e phetha karolo ea bohlokoa ho laola boholo ba setho le ho hōla ha lisele tsa liphoofolo tse anyesang. Liphuputso tse ling li bontšitse hore tsela e boetse e ameha taolong ea ho ata ha lisele, apoptosis lefu la lisele tse hlophisitsoeng, le ho inchafatsa ha lisele tsa stem. Mathoasong a lilemo tsa bo-2000, ho ile ha sibolloa hore tsela ea Likubu e boetse e ameha ho hatelleng lihlahala. Liphetoho liphatseng tsa lefutso tse amanang le tsela li fumanoe li eketsa kotsi ea ho tšoaroa ke mofetše. Ho tloha ha e sibolloa, liphuputso tse mabapi le tsela ea Li-Hippo tse bontšang matšoao li eketsehile ka potlako, me hona joale e nkoa e le sepheo se tšepisang bakeng sa ntsetsopele ea mekhoa e mecha ea phekolo ea kankere. Tsela e ntse e sa utloisisoe ka botlalo, me lipatlisiso li ntse li tsoela pele ho senola mathata a eona le litšebeliso tse ka bang teng. 