<prompt> Ke mohlala ofe oa mofuta oa phetoho liphatseng tsa lefutso o ka bakang bothata bo tebileng ba bophelo bo botle?nan  <response>: Instruction in English: What is an example of a type of mutation that can cause a serious health disorder? . Response in English: One example of a type of mutation that can cause a serious health disorder is a single nucleotide polymorphism, or SNP. This is a change in a single nucleotide A, T, C, or G within the DNA sequence. SNPs can occur in both coding and non-coding regions of the genome and can have a range of effects on health, depending on where they occur and the nature of the change. For instance, Sickle cell anemia is one example of a serious health disorder caused by a SNP - this occurs when a single nucleotide is changed in the hemoglobin gene, coding for an abnormal protein that distorts the shape of red blood cells. This results in a host of medical complications including anemia, pain, and a higher susceptibility to infections. . Response in Sesotho: Mohlala o mong oa mofuta oa phetoho e ka bakang bothata bo tebileng ba bophelo bo botle ke nucleotide polymorphism e le ngoe, kapa SNP. Ena ke phetoho ea nucleotide e le ngoe A, T, C, kapa G ka hara tatellano ea DNA. Li-SNP li ka etsahala libakeng tse peli tsa li-coding le tse se nang li-coding tsa genome me li ka ba le mefuta e mengata ea liphello tsa bophelo bo botle, ho itšetlehile ka hore na li etsahala hokae le mofuta oa phetoho. Ka mohlala, Sickle cell anemia ke mohlala o mong oa boloetse bo tebileng ba bophelo bo botle bo bakoang ke SNP - sena se etsahala ha nucleotide e le ngoe e fetoloa phatsong ea hemoglobin, e kenyang protheine e sa tloaelehang e senyang sebōpeho sa lisele tse khubelu tsa mali. Sena se fella ka mathata a mangata a bongaka a kenyeletsang phokolo ea mali, bohloko, le ho ba le monyetla o moholo oa ho tšoaetsoa. 