<prompt> Ha u fuoa phetoho ea liphatsa tsa lefutso, hlalosa hore na e bolela eng.Ho hlakoloa ha mofuta oa CFTR.  <response>: Instruction in English: Given a genetic mutation, explain what it means. . Response in English: A deletion of the CFTR gene means that certain portions of the DNA sequence of the CFTR gene have been removed or deleted. CFTR is an acronym for cystic fibrosis transmembrane conductance regulator, which is a protein responsible for the movement of salt and water in and out of cells. Since genes contain the instructions for building proteins, any change or mutation, including deletion, could alter the function of the protein it produces. In this particular case, a deletion in the CFTR gene could lead to the development of Cystic Fibrosis- a condition that affects the respiratory, digestive and reproductive systems and can lead to chronic lung infections and reduced ability to breathe over time. . Response in Sesotho: Ho hlakolwa ha lefutso la CFTR ho bolela hore dikarolo tse itseng tsa tatellano ya DNA ya lefutso la CFTR di tlositswe kapa di hlakotswe. CFTR ke khutsufatso ea cystic fibrosis transmembrane conductance regulator, e leng protheine e ikarabellang bakeng sa motsamao oa letsoai le metsi ho kena le ho tsoa liseleng. Kaha liphatsa tsa lefutso li na le litaelo tsa ho haha liprotheine, phetoho leha e le efe kapa phetoho leha e le efe, ho akarelletsa le ho hlakoloa, e ka fetola mosebetsi oa protheine eo e e hlahisang. Tabeng ena, ho hlakoloa ha lefutso la CFTR ho ka lebisa ho ntsetsopele ea Cystic Fibrosis- boemo bo amang tsamaiso ea ho hema, ea tšilo ea lijo le ea ho ikatisa me e ka lebisa ho mafu a sa foleng a matšoafo le ho fokotsa matla a ho hema ha nako e ntse e ea. 