Below is the list of tables from the database along with their columns and datatype. Need to generate an accurate SQL query for the question.
Only use the columns present in the respective table. Only use the columns which are required to generate the SQL query. Only use table joins if required and not otherwise.

### Tables ###
TABLE: CREATE TABLE medicine_enzyme_interaction (id VARCHAR, enzyme_id VARCHAR)
TABLE: CREATE TABLE enzyme (id VARCHAR, enzyme_id VARCHAR)

### Question ###
How many enzymes do not have any interactions?

### Accurate SQL ###

SELECT COUNT(*) FROM enzyme WHERE NOT id IN (SELECT enzyme_id FROM medicine_enzyme_interaction)