Below is the list of tables from the database along with their columns and datatype. Need to generate an accurate SQL query for the question.
Only use the columns present in the respective table. Only use the columns which are required to generate the SQL query. Only use table joins if required and not otherwise.

### Tables ###
TABLE: CREATE TABLE medicine ( id number, name text, trade_name text, fda_approved text )
TABLE: CREATE TABLE medicine_enzyme_interaction ( enzyme_id number, medicine_id number, interaction_type text )
TABLE: CREATE TABLE enzyme ( id number, name text, location text, product text, chromosome text, omim number, porphyria text )

### Question ###
What are the medicine and trade names that cannot interact with the enzyme with the product 'Heme'?

### Accurate SQL ###

SELECT name, trade_name FROM medicine EXCEPT SELECT T1.name, T1.trade_name FROM medicine AS T1 JOIN medicine_enzyme_interaction AS T2 ON T2.medicine_id = T1.id JOIN enzyme AS T3 ON T3.id = T2.enzyme_id WHERE T3.product = 'Protoporphyrinogen IX'