assay_chembl_id,assay_description,canonical_smiles,Source,Name,hERG_uM,Activity,pIC50
CHEMBL841079,Inhibition of hERG currents Kv11.1,O=C1NCCN1CCN1CCC(c2cn(-c3ccc(F)cc3)c3ccc(Cl)cc23)CC1,J Med Chem,CHEMBL12713,0.014,Yes,7.853871964
CHEMBL691014,K+ channel blocking activity in human embryonic kidney cells expressing HERG Kv11.1,O=C(CCCN1CC=C(n2c(=O)[nH]c3ccccc32)CC1)c1ccc(F)cc1,J Med Chem,CHEMBL1108,0.0322,Yes,7.492144128
CHEMBL691014,K+ channel blocking activity in human embryonic kidney cells expressing HERG Kv11.1,COc1ccc(CCN(C)CCCC(C#N)(c2ccc(OC)c(OC)c2)C(C)C)cc1OC,J Med Chem,CHEMBL6966,0.143,Yes,6.844663963
CHEMBL877203,K+ channel blocking activity in Chinese hamster ovary cells expressing HERG Kv11.1,CCCCN(CCCC)CCC(O)c1cc2c(Cl)cc(Cl)cc2c2cc(C(F)(F)F)ccc12,J Med Chem,CHEMBL1107,0.196,Yes,6.707743929
CHEMBL691014,K+ channel blocking activity in human embryonic kidney cells expressing HERG Kv11.1,CCOC(=O)N1CCC(=C2c3ccc(Cl)cc3CCc3cccnc32)CC1,J Med Chem,CHEMBL998,0.173,Yes,6.761953897
CHEMBL691014,K+ channel blocking activity in human embryonic kidney cells expressing HERG Kv11.1,O=C1NCCN1CCN1CCC(c2cn(-c3ccc(F)cc3)c3ccc(Cl)cc23)CC1,J Med Chem,CHEMBL12713,0.014,Yes,7.853871964
CHEMBL822598,K+ channel blocking activity in human embryonic kidney cells expressing HERG Kv11.1,COC(=O)[C@H]1[C@@H](OC(=O)c2ccccc2)C[C@@H]2CC[C@H]1N2C,J Med Chem,CHEMBL370805,0.0044,Yes,8.356547324
CHEMBL822598,K+ channel blocking activity in human embryonic kidney cells expressing HERG Kv11.1,O=C1Cc2cc(CCN3CCN(c4nsc5ccccc45)CC3)c(Cl)cc2N1,J Med Chem,CHEMBL708,0.152,Yes,6.818156412
CHEMBL749472,K+ channel blocking activity in neuroblastoma cells expressing HERG Kv11.1,COc1ccc(Cl)cc1C(=O)NCCc1ccc(S(=O)(=O)NC(=O)NC2CCCCC2)cc1,J Med Chem,CHEMBL472,74,No,4.13076828
CHEMBL691014,K+ channel blocking activity in human embryonic kidney cells expressing HERG Kv11.1,CCCc1nn(C)c2c(=O)[nH]c(-c3cc(S(=O)(=O)N4CCN(C)CC4)ccc3OCC)nc12,J Med Chem,CHEMBL192,100,No,4
CHEMBL662305,K+ channel blocking activity in Chinese hamster ovary cells expressing HERG Kv11.1,COc1c(N2C[C@@H]3CCCN[C@@H]3C2)c(F)cc2c(=O)c(C(=O)O)cn(C3CC3)c12,J Med Chem,CHEMBL32,129,No,3.88941029
CHEMBL662305,K+ channel blocking activity in Chinese hamster ovary cells expressing HERG Kv11.1,COc1c(N2CCNC(C)C2)c(F)cc2c(=O)c(C(=O)O)cn(C3CC3)c12,J Med Chem,CHEMBL31,130,No,3.886056648
CHEMBL656604,K+ channel blocking activity in COS-7 African green monkey kidney derived cells expressing HERG Kv11.1,CC(C)COCC(CN(Cc1ccccc1)c1ccccc1)N1CCCC1,J Med Chem,CHEMBL1008,0.55,Yes,6.259637311
CHEMBL691014,K+ channel blocking activity in human embryonic kidney cells expressing HERG Kv11.1,CN(CCOc1ccc(NS(C)(=O)=O)cc1)CCc1ccc(NS(C)(=O)=O)cc1,J Med Chem,CHEMBL473,0.015,Yes,7.823908741
CHEMBL662305,K+ channel blocking activity in Chinese hamster ovary cells expressing HERG Kv11.1,Cc1c(F)c(N2CCNC(C)C2)cc2c1c(=O)c(C(=O)O)cn2C1CC1,J Med Chem,CHEMBL583,104,No,3.982966661
CHEMBL691013,K+ channel blocking activity in human embryonic kidney cells expressing HERG Kv11.1,COc1ccc(CCN2CCC(Nc3nc4ccccc4n3Cc3ccc(F)cc3)CC2)cc1,J Med Chem,CHEMBL296419,0.0009,Yes,9.045757491
CHEMBL691014,K+ channel blocking activity in human embryonic kidney cells expressing HERG Kv11.1,O=C(CCCN1CCC(O)(c2ccc(Cl)cc2)CC1)c1ccc(F)cc1,J Med Chem,CHEMBL54,0.0281,Yes,7.55129368
CHEMBL822598,K+ channel blocking activity in human embryonic kidney cells expressing HERG Kv11.1,Fc1ccc(Cn2c(NC3CCNCC3)nc3ccccc32)cc1,J Med Chem,CHEMBL61301,0.028,Yes,7.552841969
CHEMBL691014,K+ channel blocking activity in human embryonic kidney cells expressing HERG Kv11.1,CC(C)(C)c1ccc(C(O)CCCN2CCC(C(O)(c3ccccc3)c3ccccc3)CC2)cc1,J Med Chem,CHEMBL17157,0.204,Yes,6.690369833
CHEMBL691014,K+ channel blocking activity in human embryonic kidney cells expressing HERG Kv11.1,O=c1[nH]c2ccccc2n1C1CCN(CCCC(c2ccc(F)cc2)c2ccc(F)cc2)CC1,J Med Chem,CHEMBL1423,0.018,Yes,7.744727495
CHEMBL822598,K+ channel blocking activity in human embryonic kidney cells expressing HERG Kv11.1,CN1CCN(C2=Nc3cc(Cl)ccc3Nc3ccccc32)CC1,J Med Chem,CHEMBL42,0.191,Yes,6.718966633
CHEMBL691014,K+ channel blocking activity in human embryonic kidney cells expressing HERG Kv11.1,COc1cc(N)c(Cl)cc1C(=O)NC1CCN(CCCOc2ccc(F)cc2)CC1OC,J Med Chem,CHEMBL1729,0.0065,Yes,8.187086643
CHEMBL691014,K+ channel blocking activity in human embryonic kidney cells expressing HERG Kv11.1,Cc1cccc(CCN2CCC(C(=O)c3ccc(NS(C)(=O)=O)cc3)CC2)n1,J Med Chem,CHEMBL327980,0.0077,Yes,8.113509275
CHEMBL875385,K+ channel blocking activity in human embryonic kidney cells expressing HERG Kv11.1,C[C@@H]1CN(c2c(F)c(N)c3c(=O)c(C(=O)O)cn(C4CC4)c3c2F)C[C@H](C)N1,J Med Chem,CHEMBL850,34.4,No,4.463441557
CHEMBL691014,K+ channel blocking activity in human embryonic kidney cells expressing HERG Kv11.1,O=c1[nH]c2ccccc2n1CCCN1CCC(n2c(=O)[nH]c3cc(Cl)ccc32)CC1,J Med Chem,CHEMBL219916,0.162,Yes,6.790484985
CHEMBL822598,K+ channel blocking activity in human embryonic kidney cells expressing HERG Kv11.1,Cc1nc2n(c(=O)c1CCN1CCC(c3noc4cc(F)ccc34)CC1)CCCC2,J Med Chem,CHEMBL85,0.163,Yes,6.787812396
CHEMBL691014,K+ channel blocking activity in human embryonic kidney cells expressing HERG Kv11.1,CN(c1nccc(=O)[nH]1)C1CCN(c2nc3ccccc3n2Cc2ccc(F)cc2)CC1,J Med Chem,CHEMBL94454,0.35,Yes,6.455931956
CHEMBL662305,K+ channel blocking activity in Chinese hamster ovary cells expressing HERG Kv11.1,CN1CCN(CCCCN2C(=O)CN(/N=C/c3ccc(-c4ccc(Cl)cc4)o3)C2=O)CC1,J Med Chem,CHEMBL123558,0.56,Yes,6.251811973
CHEMBL691014,K+ channel blocking activity in human embryonic kidney cells expressing HERG Kv11.1,CSc1ccc2c(c1)N(CCC1CCCCN1C)c1ccccc1S2,J Med Chem,CHEMBL479,0.0357,Yes,7.447331784
CHEMBL686879,Inhibition of Ikr current in isolated guinea pig myocytes during a 0.5 s voltage clamp step from -50 to -10 mV.,CN(C)CCN1C(=O)C(NC(=O)CCc2ccc(Cl)cc2Cl)N=C(c2ccccc2)c2ccccc21,J Med Chem,CHEMBL128007,0.1,Yes,7
CHEMBL766816,Inhibition of K+ channel activity in CHO cells expressing HERG Kv11.1,O=C1NCCN1CCN1CCC(c2cn(-c3ccccc3)c3ccc(Cl)cc23)CC1,Bioorg Med Chem Lett,CHEMBL443476,0.088,Yes,7.055517328
CHEMBL766816,Inhibition of K+ channel activity in CHO cells expressing HERG Kv11.1,O=C1NCCN1CCN1CCC(c2cn(C3CCCCC3)c3ccc(Cl)cc23)CC1,Bioorg Med Chem Lett,CHEMBL53661,0.137,Yes,6.863279433
CHEMBL766816,Inhibition of K+ channel activity in CHO cells expressing HERG Kv11.1,O=C1NCCN1CCN1CC=C(c2cn(-c3ccc(F)cc3)c3ccc(Cl)cc23)CC1,Bioorg Med Chem Lett,CHEMBL12186,0.01,Yes,8
CHEMBL766816,Inhibition of K+ channel activity in CHO cells expressing HERG Kv11.1,O=C1NCCN1CCN1CCC(C2CN(c3ccc(F)cc3)c3ccccc32)CC1,Bioorg Med Chem Lett,CHEMBL556312,0.0235,Yes,7.628932138
CHEMBL766816,Inhibition of K+ channel activity in CHO cells expressing HERG Kv11.1,COc1cc(N)c(Cl)cc1C(=O)NC1CCN(CCCOc2ccc(F)cc2)CC1OC,Bioorg Med Chem Lett,CHEMBL1729,0.045,Yes,7.346787486
CHEMBL766816,Inhibition of K+ channel activity in CHO cells expressing HERG Kv11.1,COc1ccc(CCN(C)CCCC(C#N)(c2ccc(OC)c(OC)c2)C(C)C)cc1OC,Bioorg Med Chem Lett,CHEMBL6966,0.143,Yes,6.844663963
CHEMBL766816,Inhibition of K+ channel activity in CHO cells expressing HERG Kv11.1,O=C(O)Cc1ccc(-n2cc(C3CCN(CCN4CCNC4=O)CC3)c3cc(Cl)ccc32)cc1,Bioorg Med Chem Lett,CHEMBL55835,0.579,Yes,6.237321436
CHEMBL766816,Inhibition of K+ channel activity in CHO cells expressing HERG Kv11.1,CC(C)(C)c1ccc(C(O)CCCN2CCC(C(O)(c3ccccc3)c3ccccc3)CC2)cc1,Bioorg Med Chem Lett,CHEMBL17157,0.056,Yes,7.251811973
CHEMBL766816,Inhibition of K+ channel activity in CHO cells expressing HERG Kv11.1,Fc1ccc(-n2cc(C3CCN(CCN4CCN=C4S)CC3)c3ccccc32)cc1,Bioorg Med Chem Lett,CHEMBL298978,0.0062,Yes,8.207608311
CHEMBL766816,Inhibition of K+ channel activity in CHO cells expressing HERG Kv11.1,O=C(O)c1ccc(-n2cc(C3CCN(CCN4CCNC4=O)CC3)c3cc(Cl)ccc32)cc1,Bioorg Med Chem Lett,CHEMBL300927,75,No,4.124938737
CHEMBL766816,Inhibition of K+ channel activity in CHO cells expressing HERG Kv11.1,CN(CCOc1ccc(NS(C)(=O)=O)cc1)CCc1ccc(NS(C)(=O)=O)cc1,Bioorg Med Chem Lett,CHEMBL473,0.01,Yes,8
CHEMBL766816,Inhibition of K+ channel activity in CHO cells expressing HERG Kv11.1,CN(C)Cc1cn(-c2ccc(F)cc2)c2ccc(Cl)cc12,Bioorg Med Chem Lett,CHEMBL301956,0.011,Yes,7.958607315
CHEMBL766816,Inhibition of K+ channel activity in CHO cells expressing HERG Kv11.1,O=C(CCCN1CCC(O)(c2ccc(Cl)cc2)CC1)c1ccc(F)cc1,Bioorg Med Chem Lett,CHEMBL54,0.032,Yes,7.494850022
CHEMBL766816,Inhibition of K+ channel activity in CHO cells expressing HERG Kv11.1,O=C1NCCN1CCN1CCC(c2cn(-c3ccc(F)cc3)c3ccccc23)CC1,Bioorg Med Chem Lett,CHEMBL12780,0.007,Yes,8.15490196
CHEMBL766816,Inhibition of K+ channel activity in CHO cells expressing HERG Kv11.1,COC(=O)Cc1ccc(-n2cc(C3CCN(CCN4CCNC4=O)CC3)c3cc(Cl)ccc32)cc1,Bioorg Med Chem Lett,CHEMBL415944,0.131,Yes,6.882728704
CHEMBL766816,Inhibition of K+ channel activity in CHO cells expressing HERG Kv11.1,CS(=O)(=O)Nc1ccc2c(c1)C(O)CC1(CCN(C3CCc4cc(C#N)ccc4C3)CC1)O2,Bioorg Med Chem Lett,CHEMBL52627,0.034,Yes,7.468521083
CHEMBL766816,Inhibition of K+ channel activity in CHO cells expressing HERG Kv11.1,CC(C)(O)c1ccc(C(O)CCCN2CCC(C(O)(c3ccccc3)c3ccccc3)CC2)cc1,Bioorg Med Chem Lett,CHEMBL52832,0.46,Yes,6.337242168
CHEMBL766816,Inhibition of K+ channel activity in CHO cells expressing HERG Kv11.1,COC(=O)c1ccc(-n2cc(C3CCN(CCN4CCNC4=O)CC3)c3cc(Cl)ccc32)cc1,Bioorg Med Chem Lett,CHEMBL52999,0.036,Yes,7.443697499
CHEMBL766816,Inhibition of K+ channel activity in CHO cells expressing HERG Kv11.1,Fc1ccc(-n2cc(C3CCNCC3)c3cc(Cl)ccc32)cc1,Bioorg Med Chem Lett,CHEMBL273235,0.204,Yes,6.690369833
CHEMBL766816,Inhibition of K+ channel activity in CHO cells expressing HERG Kv11.1,O=C1NCCN1CCN1CCC(c2cn(-c3ccc(F)cc3)c3ccc(Cl)cc23)CC1,Bioorg Med Chem Lett,CHEMBL12713,0.003,Yes,8.522878745
CHEMBL766816,Inhibition of K+ channel activity in CHO cells expressing HERG Kv11.1,O=c1[nH]c2ccccc2n1C1CCN(CCCC(c2ccc(F)cc2)c2ccc(F)cc2)CC1,Bioorg Med Chem Lett,CHEMBL1423,0.018,Yes,7.744727495
CHEMBL768686,Inhibitory activity against Potassium channel HERG,COc1cc(N)c(Cl)cc1C(=O)NC1CCN(CCCOc2ccc(F)cc2)CC1OC,J Med Chem,CHEMBL1729,0.047,Yes,7.327902142
CHEMBL768686,Inhibitory activity against Potassium channel HERG,O=C1NCCN1CCN1CCC(c2cn(-c3ccc(F)cc3)c3ccc(Cl)cc23)CC1,J Med Chem,CHEMBL12713,0.003,Yes,8.522878745
CHEMBL768686,Inhibitory activity against Potassium channel HERG,Cc1c(F)c(N2CCNC(C)C2)cc2c1c(=O)c(C(=O)O)cn2C1CC1,J Med Chem,CHEMBL583,50,No,4.301029996
CHEMBL768686,Inhibitory activity against Potassium channel HERG,O=c1[nH]c2ccccc2n1C1CCN(CCCC(c2ccc(F)cc2)c2ccc(F)cc2)CC1,J Med Chem,CHEMBL1423,0.018,Yes,7.744727495
CHEMBL768686,Inhibitory activity against Potassium channel HERG,COc1ccc(CCN2CCC(Nc3nc4ccccc4n3Cc3ccc(F)cc3)CC2)cc1,J Med Chem,CHEMBL296419,0.0009,Yes,9.045757491
CHEMBL768686,Inhibitory activity against Potassium channel HERG,CC(C)(C)c1ccc(C(O)CCCN2CCC(C(O)(c3ccccc3)c3ccccc3)CC2)cc1,J Med Chem,CHEMBL17157,0.056,Yes,7.251811973
CHEMBL768686,Inhibitory activity against Potassium channel HERG,CSc1ccc2c(c1)N(CCC1CCCCN1C)c1ccccc1S2,J Med Chem,CHEMBL479,0.191,Yes,6.718966633
CHEMBL766814,Inhibition of human Potassium channel HERG expressed in mammalian cells,COC(=O)C1=C(C)NC(C)=C(C(=O)OC)C1c1ccccc1[N+](=O)[O-],Bioorg Med Chem Lett,CHEMBL193,50.11872,No,4.300000029
CHEMBL766814,Inhibition of human Potassium channel HERG expressed in mammalian cells,CN(CCOc1ccc(NS(C)(=O)=O)cc1)CCc1ccc(NS(C)(=O)=O)cc1,Bioorg Med Chem Lett,CHEMBL473,0.01,Yes,8
CHEMBL766814,Inhibition of human Potassium channel HERG expressed in mammalian cells,CCOC(=O)N1CCC(=C2c3ccc(Cl)cc3CCc3cccnc32)CC1,Bioorg Med Chem Lett,CHEMBL998,0.16982,Yes,6.770011163
CHEMBL766814,Inhibition of human Potassium channel HERG expressed in mammalian cells,Oc1ccc(CCN2CCC(Nc3nc4ccccc4n3Cc3ccc(F)cc3)CC2)cc1,Bioorg Med Chem Lett,CHEMBL60796,0.001,Yes,9
CHEMBL766814,Inhibition of human Potassium channel HERG expressed in mammalian cells,CC(C)COCC(CN(Cc1ccccc1)c1ccccc1)N1CCCC1,Bioorg Med Chem Lett,CHEMBL1008,0.54954,Yes,6.260000691
CHEMBL766814,Inhibition of human Potassium channel HERG expressed in mammalian cells,C[C@H]1COc2c(N3CCN(C)CC3)c(F)cc3c(=O)c(C(=O)O)cn1c23,Bioorg Med Chem Lett,CHEMBL33,912.01084,No,3.04
CHEMBL766814,Inhibition of human Potassium channel HERG expressed in mammalian cells,CCCCN(CCCC)CCC(O)c1cc2c(Cl)cc(Cl)cc2c2cc(C(F)(F)F)ccc12,Bioorg Med Chem Lett,CHEMBL1107,0.19953,Yes,6.699991797
CHEMBL684971,Blockade of the delayed rectifier K+ current (IKr) of guinea pig myocytes,CSc1ccc([C@@H]2N=C(OCc3ccc(NS(C)(=O)=O)cc3)N(C)Cc3ccccc32)cc1.Cl,J Med Chem,CHEMBL3350235,56,No,4.251811973
CHEMBL766814,Inhibition of human Potassium channel HERG expressed in mammalian cells,COc1ccc(CCN2CCC(Nc3nc4ccccc4n3Cc3ccc(F)cc3)CC2)cc1,Bioorg Med Chem Lett,CHEMBL296419,0.006026,Yes,8.219970873
CHEMBL766814,Inhibition of human Potassium channel HERG expressed in mammalian cells,CCCCCCCN(CC)CCCC(O)c1ccc(NS(C)(=O)=O)cc1,Bioorg Med Chem Lett,CHEMBL533,0.01,Yes,8
CHEMBL766814,Inhibition of human Potassium channel HERG expressed in mammalian cells,COc1cc(N)c(Cl)cc1C(=O)NC1CCN(CCCOc2ccc(F)cc2)CC1OC,Bioorg Med Chem Lett,CHEMBL1729,0.03981,Yes,7.400007822
CHEMBL766814,Inhibition of human Potassium channel HERG expressed in mammalian cells,CC(C)N(CCC(C(N)=O)(c1ccccc1)c1ccccn1)C(C)C,Bioorg Med Chem Lett,CHEMBL517,91.20108,No,4.040000019
CHEMBL766814,Inhibition of human Potassium channel HERG expressed in mammalian cells,CC1COc2c(N3CCN(C)CC3)c(F)cc3c(=O)c(C(=O)O)cn1c23,Bioorg Med Chem Lett,CHEMBL4,1412.53754,No,2.850000001
CHEMBL687333,Blockade of the delayed rectifier K+ current (IKr) of guinea pig myocytes,CN1Cc2ccccc2[C@@H](c2ccccc2)N=C1OCc1ccc(NS(C)(=O)=O)cc1.O=C(O)/C=C/C(=O)O,J Med Chem,CHEMBL1788206,38,No,4.420216403
CHEMBL684971,Blockade of the delayed rectifier K+ current (IKr) of guinea pig myocytes,CN1Cc2ccccc2[C@H](c2ccc(F)cc2F)N=C1CCc1ccc(NS(C)(=O)=O)cc1.Cl,J Med Chem,CHEMBL1788304,85,No,4.070581074
CHEMBL766814,Inhibition of human Potassium channel HERG expressed in mammalian cells,O=C(CCCN1CCC(O)(c2ccc(Cl)cc2)CC1)c1ccc(F)cc1,Bioorg Med Chem Lett,CHEMBL54,0.0302,Yes,7.519993057
CHEMBL766814,Inhibition of human Potassium channel HERG expressed in mammalian cells,CN(c1nccc(=O)[nH]1)C1CCN(c2nc3ccccc3n2Cc2ccc(F)cc2)CC1,Bioorg Med Chem Lett,CHEMBL94454,0.43652,Yes,6.359995853
CHEMBL766814,Inhibition of human Potassium channel HERG expressed in mammalian cells,O=C(O)c1cn(C2CC2)c2cc(N3CCNCC3)c(F)cc2c1=O,Bioorg Med Chem Lett,CHEMBL8,954.99259,No,3.019999998
CHEMBL766814,Inhibition of human Potassium channel HERG expressed in mammalian cells,CN1CCN(C2=Nc3cc(Cl)ccc3Nc3ccccc32)CC1,Bioorg Med Chem Lett,CHEMBL42,0.32359,Yes,6.490004908
CHEMBL766814,Inhibition of human Potassium channel HERG expressed in mammalian cells,CSc1ccc2c(c1)N(CCC1CCCCN1C)c1ccccc1S2,Bioorg Med Chem Lett,CHEMBL479,0.36308,Yes,6.439997673
CHEMBL766814,Inhibition of human Potassium channel HERG expressed in mammalian cells,COc1c(N2CCNC(C)C2)c(F)cc2c(=O)c(C(=O)O)cn(C3CC3)c12,Bioorg Med Chem Lett,CHEMBL31,128.82496,No,3.889999984
CHEMBL766814,Inhibition of human Potassium channel HERG expressed in mammalian cells,CC(C)(C)c1ccc(C(O)CCCN2CCC(C(O)(c3ccccc3)c3ccccc3)CC2)cc1,Bioorg Med Chem Lett,CHEMBL17157,0.19953,Yes,6.699991797
CHEMBL766814,Inhibition of human Potassium channel HERG expressed in mammalian cells,Cc1c(F)c(N2CCNC(C)C2)cc2c1c(=O)c(C(=O)O)cn2C1CC1,Bioorg Med Chem Lett,CHEMBL583,50.11872,No,4.300000029
CHEMBL766814,Inhibition of human Potassium channel HERG expressed in mammalian cells,COc1cc(Cc2cnc(N)nc2N)cc(OC)c1OC,Bioorg Med Chem Lett,CHEMBL22,239.88329,No,3.620000003
CHEMBL766814,Inhibition of human Potassium channel HERG expressed in mammalian cells,O=C(O)COCCN1CCN(C(c2ccccc2)c2ccc(Cl)cc2)CC1,Bioorg Med Chem Lett,CHEMBL1000,30.19952,No,4.51999996
CHEMBL766814,Inhibition of human Potassium channel HERG expressed in mammalian cells,COc1ccc(CCN(C)CCCC(C#N)(c2ccc(OC)c(OC)c2)C(C)C)cc1OC,Bioorg Med Chem Lett,CHEMBL6966,0.14125,Yes,6.850011544
CHEMBL766814,Inhibition of human Potassium channel HERG expressed in mammalian cells,Cc1nc2n(c(=O)c1CCN1CCC(c3noc4cc(F)ccc34)CC1)CCCC2,Bioorg Med Chem Lett,CHEMBL85,0.15136,Yes,6.819988881
CHEMBL684971,Blockade of the delayed rectifier K+ current (IKr) of guinea pig myocytes,CN(CCOc1ccc(NS(C)(=O)=O)cc1)CCc1ccc(NS(C)(=O)=O)cc1,J Med Chem,CHEMBL473,44,No,4.356547324
CHEMBL766814,Inhibition of human Potassium channel HERG expressed in mammalian cells,COc1ccc(CCN2CCC(Nc3nc4ccccc4n3Cc3ccc(F)cc3)CC2)cc1,Bioorg Med Chem Lett,CHEMBL296419,0.01,Yes,8
CHEMBL766814,Inhibition of human Potassium channel HERG expressed in mammalian cells,CN1CCC[C@H]1c1cccnc1,Bioorg Med Chem Lett,CHEMBL3,245.47089,No,3.610000003
CHEMBL766814,Inhibition of human Potassium channel HERG expressed in mammalian cells,O=c1[nH]c2ccccc2n1C1CCN(CCCC(c2ccc(F)cc2)c2ccc(F)cc2)CC1,Bioorg Med Chem Lett,CHEMBL1423,0.05012,Yes,7.299988938
CHEMBL766814,Inhibition of human Potassium channel HERG expressed in mammalian cells,O=C1NCCN1CCN1CCC(c2cn(-c3ccc(F)cc3)c3ccc(Cl)cc23)CC1,Bioorg Med Chem Lett,CHEMBL12713,0.01,Yes,8
CHEMBL766814,Inhibition of human Potassium channel HERG expressed in mammalian cells,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(OC)C[C@@H](C)C(=O)[C@H](C)[C@@H](O)[C@]1(C)O,Bioorg Med Chem Lett,CHEMBL1741,58.88437,No,4.229999967
CHEMBL766815,Inhibition of K+ channel activity in mammalian cells expressing HERG Kv11.1,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(OC)C[C@@H](C)C(=O)[C@H](C)[C@@H](O)[C@]1(C)O,Bioorg Med Chem Lett,CHEMBL1741,33.11311,No,4.480000028
CHEMBL766814,Inhibition of human Potassium channel HERG expressed in mammalian cells,COc1c(N2C[C@@H]3CCCN[C@@H]3C2)c(F)cc2c(=O)c(C(=O)O)cn(C3CC3)c12,Bioorg Med Chem Lett,CHEMBL32,128.82496,No,3.889999984
CHEMBL766814,Inhibition of human Potassium channel HERG expressed in mammalian cells,O=C(CCCN1CC=C(n2c(=O)[nH]c3ccccc32)CC1)c1ccc(F)cc1,Bioorg Med Chem Lett,CHEMBL1108,0.03236,Yes,7.489991487
CHEMBL766814,Inhibition of human Potassium channel HERG expressed in mammalian cells,CN1CCCCC1CCN1c2ccccc2Sc2ccc([S+](C)[O-])cc21,Bioorg Med Chem Lett,CHEMBL1088,0.32359,Yes,6.490004908
CHEMBL766814,Inhibition of human Potassium channel HERG expressed in mammalian cells,COc1ccc(C2CCN(CC[C@H]3CCOc4ccccc43)CC2)cc1OC,Bioorg Med Chem Lett,CHEMBL96153,0.25119,Yes,6.599997654
CHEMBL766814,Inhibition of human Potassium channel HERG expressed in mammalian cells,COc1ccc(C2CCN(CCC3CCOc4ccccc43)CC2)cc1OC,Bioorg Med Chem Lett,CHEMBL94664,0.19953,Yes,6.699991797
CHEMBL766814,Inhibition of human Potassium channel HERG expressed in mammalian cells,NC1=NCC2c3ccccc3Cc3ccccc3N12,Bioorg Med Chem Lett,CHEMBL1106,100,No,4
CHEMBL766814,Inhibition of human Potassium channel HERG expressed in mammalian cells,Cc1nccn1CC1CCc2c(c3ccccc3n2C)C1=O,Bioorg Med Chem Lett,CHEMBL46,0.81283,Yes,6.090000276
CHEMBL766814,Inhibition of human Potassium channel HERG expressed in mammalian cells,C=C[C@H]1CN2CC[C@H]1C[C@@H]2[C@@H](O)c1ccnc2ccc(OC)cc12,Bioorg Med Chem Lett,CHEMBL1294,0.32359,Yes,6.490004908
CHEMBL766814,Inhibition of human Potassium channel HERG expressed in mammalian cells,Cc1cc2c(s1)Nc1ccccc1N=C2N1CCN(C)CC1,Bioorg Med Chem Lett,CHEMBL715,0.18197,Yes,6.740000205
CHEMBL684971,Blockade of the delayed rectifier K+ current (IKr) of guinea pig myocytes,CN1Cc2ccccc2[C@@H](c2ccc(F)cc2F)N=C1CCc1ccc(NS(C)(=O)=O)cc1.Cl,J Med Chem,CHEMBL2092890,38,No,4.420216403
CHEMBL766814,Inhibition of human Potassium channel HERG expressed in mammalian cells,Cl.O=C1Cc2cc(CCN3CCN(c4nsc5ccccc45)CC3)c(Cl)cc2N1,Bioorg Med Chem Lett,CHEMBL1712,0.12023,Yes,6.919987153
CHEMBL766814,Inhibition of human Potassium channel HERG expressed in mammalian cells,Cc1cccc(CCN2CCC(C(=O)c3ccc(NS(C)(=O)=O)cc3)CC2)n1,Bioorg Med Chem Lett,CHEMBL327980,0.01995,Yes,7.7000571
CHEMBL766814,Inhibition of human Potassium channel HERG expressed in mammalian cells,Fc1ccc(Cn2c(NC3CCNCC3)nc3ccccc32)cc1,Bioorg Med Chem Lett,CHEMBL61301,0.02818,Yes,7.550059011
CHEMBL827917,Inhibition of Potassium channel HERG,CN(C)CCCn1nc(C2=C(c3cn(-c4ccc5ccccc5c4)c4ccccc34)C(=O)NC2=O)c2ccccc21,J Med Chem,CHEMBL368895,0.028,Yes,7.552841969
CHEMBL832717,Inhibitory concentration against human Kv11.1 ERG potassium channel,CC(C)(Cc1ccc2ccccc2c1)NC[C@@H](O)COc1cccc(Cl)c1C#N,Bioorg Med Chem Lett,CHEMBL180672,0.194,Yes,6.71219827
CHEMBL832277,Inhibition of human voltage-gated potassium channel subunit Kv11.1 (ERG K+ channel) in open state,COc1ccc(CCN2CCC(Nc3nc4ccccc4n3Cc3ccc(F)cc3)CC2)cc1,Bioorg Med Chem Lett,CHEMBL296419,0.000912,Yes,9.040005162
CHEMBL832277,Inhibition of human voltage-gated potassium channel subunit Kv11.1 (ERG K+ channel) in open state,CN1CCN(CCCCN2C(=O)CN(/N=C/c3ccc(-c4ccc(Cl)cc4)o3)C2=O)CC1.Cl,Bioorg Med Chem Lett,CHEMBL537847,0.56234,Yes,6.250001023
CHEMBL832277,Inhibition of human voltage-gated potassium channel subunit Kv11.1 (ERG K+ channel) in open state,CC(C)COCC(CN(Cc1ccccc1)c1ccccc1)N1CCCC1,Bioorg Med Chem Lett,CHEMBL1008,0.54954,Yes,6.260000691
CHEMBL832277,Inhibition of human voltage-gated potassium channel subunit Kv11.1 (ERG K+ channel) in open state,O=c1[nH]c2ccccc2n1CCCN1CCC(n2c(=O)[nH]c3cc(Cl)ccc32)CC1,Bioorg Med Chem Lett,CHEMBL219916,0.16218,Yes,6.790002704
CHEMBL832277,Inhibition of human voltage-gated potassium channel subunit Kv11.1 (ERG K+ channel) in open state,O=C(CCCN1CC=C(n2c(=O)[nH]c3ccccc32)CC1)c1ccc(F)cc1,Bioorg Med Chem Lett,CHEMBL1108,0.03236,Yes,7.489991487
CHEMBL832277,Inhibition of human voltage-gated potassium channel subunit Kv11.1 (ERG K+ channel) in open state,COc1c(N2CCNC(C)C2)c(F)cc2c(=O)c(C(=O)O)cn(C3CC3)c12,Bioorg Med Chem Lett,CHEMBL31,128.82496,No,3.889999984
CHEMBL832277,Inhibition of human voltage-gated potassium channel subunit Kv11.1 (ERG K+ channel) in open state,Cc1c(F)c(N2CCNC(C)C2)cc2c1c(=O)c(C(=O)O)cn2C1CC1,Bioorg Med Chem Lett,CHEMBL583,77.62471,No,4.110000009
CHEMBL832277,Inhibition of human voltage-gated potassium channel subunit Kv11.1 (ERG K+ channel) in open state,CCCCN(CCCC)CCC(O)c1cc2c(Cl)cc(Cl)cc2c2cc(C(F)(F)F)ccc12,Bioorg Med Chem Lett,CHEMBL1107,0.19953,Yes,6.699991797
CHEMBL832277,Inhibition of human voltage-gated potassium channel subunit Kv11.1 (ERG K+ channel) in open state,O=C(CCCN1CCC(O)(c2ccc(Cl)cc2)CC1)c1ccc(F)cc1,Bioorg Med Chem Lett,CHEMBL54,0.02818,Yes,7.550059011
CHEMBL832277,Inhibition of human voltage-gated potassium channel subunit Kv11.1 (ERG K+ channel) in open state,COc1c(N2C[C@@H]3CCCN[C@@H]3C2)c(F)cc2c(=O)c(C(=O)O)cn(C3CC3)c12,Bioorg Med Chem Lett,CHEMBL32,117.48976,No,3.929999983
CHEMBL832277,Inhibition of human voltage-gated potassium channel subunit Kv11.1 (ERG K+ channel) in open state,Fc1ccc(Cn2c(NC3CCNCC3)nc3ccccc32)cc1,Bioorg Med Chem Lett,CHEMBL61301,0.02818,Yes,7.550059011
CHEMBL832277,Inhibition of human voltage-gated potassium channel subunit Kv11.1 (ERG K+ channel) in open state,O=c1[nH]c2ccccc2n1C1CCN(CCCC(c2ccc(F)cc2)c2ccc(F)cc2)CC1,Bioorg Med Chem Lett,CHEMBL1423,0.0182,Yes,7.739928612
CHEMBL832277,Inhibition of human voltage-gated potassium channel subunit Kv11.1 (ERG K+ channel) in open state,Cc1nc2n(c(=O)c1CCN1CCC(c3noc4cc(F)ccc34)CC1)CCCC2,Bioorg Med Chem Lett,CHEMBL85,0.16218,Yes,6.790002704
CHEMBL832277,Inhibition of human voltage-gated potassium channel subunit Kv11.1 (ERG K+ channel) in open state,O=C1NCCN1CCN1CCC(c2cn(-c3ccc(F)cc3)c3ccc(Cl)cc23)CC1,Bioorg Med Chem Lett,CHEMBL12713,0.01413,Yes,7.849857838
CHEMBL832277,Inhibition of human voltage-gated potassium channel subunit Kv11.1 (ERG K+ channel) in open state,COc1ccc(CCN(C)CCCC(C#N)(c2ccc(OC)c(OC)c2)C(C)C)cc1OC,Bioorg Med Chem Lett,CHEMBL6966,0.14454,Yes,6.84001195
CHEMBL832278,Inhibition of partially open human voltage-gated potassium channel subunit Kv11.1 (ERG K+ channel),COc1cc(N)c(Cl)cc1C(=O)NC1CCN(CCCOc2ccc(F)cc2)CC1OC,Bioorg Med Chem Lett,CHEMBL1729,0.006457,Yes,8.189969214
CHEMBL832278,Inhibition of partially open human voltage-gated potassium channel subunit Kv11.1 (ERG K+ channel),CN(c1nccc(=O)[nH]1)C1CCN(c2nc3ccccc3n2Cc2ccc(F)cc2)CC1,Bioorg Med Chem Lett,CHEMBL94454,0.35481,Yes,6.450004148
CHEMBL832278,Inhibition of partially open human voltage-gated potassium channel subunit Kv11.1 (ERG K+ channel),CC(C)(C)c1ccc(C(O)CCCN2CCC(C(O)(c3ccccc3)c3ccccc3)CC2)cc1,Bioorg Med Chem Lett,CHEMBL17157,0.12882,Yes,6.890016705
CHEMBL832278,Inhibition of partially open human voltage-gated potassium channel subunit Kv11.1 (ERG K+ channel),CSc1ccc2c(c1)N(CCC1CCCCN1C)c1ccccc1S2,Bioorg Med Chem Lett,CHEMBL479,0.03548,Yes,7.450016389
CHEMBL832278,Inhibition of partially open human voltage-gated potassium channel subunit Kv11.1 (ERG K+ channel),O=C1Cc2cc(CCN3CCN(c4nsc5ccccc45)CC3)c(Cl)cc2N1,Bioorg Med Chem Lett,CHEMBL708,0.15136,Yes,6.819988881
CHEMBL827807,Inhibitory concentration against IKr potassium channel,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)C(=O)[C@H](C)[C@@H](O)[C@]1(C)O,Bioorg Med Chem Lett,CHEMBL532,39,No,4.408935393
CHEMBL827807,Inhibitory concentration against IKr potassium channel,CCCNCC(O)COc1ccc(O)cc1C(=O)CCc1ccccc1,Bioorg Med Chem Lett,CHEMBL1264,40,No,4.397940009
CHEMBL827807,Inhibitory concentration against IKr potassium channel,NCC(O)COc1ccccc1C(=O)CCc1ccccc1,Bioorg Med Chem Lett,CHEMBL1365,44,No,4.356547324
CHEMBL827807,Inhibitory concentration against IKr potassium channel,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(OC)C[C@@H](C)C(=O)[C@H](C)[C@@H](O)[C@]1(C)O,Bioorg Med Chem Lett,CHEMBL1741,46,No,4.337242168
CHEMBL827807,Inhibitory concentration against IKr potassium channel,O=C(O)COCCN1CCN(C(c2ccccc2)c2ccc(Cl)cc2)CC1,Bioorg Med Chem Lett,CHEMBL1000,108,No,3.966576245
CHEMBL827807,Inhibitory concentration against IKr potassium channel,O=C1NC(=O)C(c2ccccc2)(c2ccccc2)N1,Bioorg Med Chem Lett,CHEMBL16,240,No,3.619788758
CHEMBL827807,Inhibitory concentration against IKr potassium channel,CCC1(c2ccccc2)C(=O)NC(=O)NC1=O,Bioorg Med Chem Lett,CHEMBL40,3000,No,2.522878745
CHEMBL827807,Inhibitory concentration against IKr potassium channel,Nc1ccncc1,Bioorg Med Chem Lett,CHEMBL284348,4400,No,2.356547324
CHEMBL827807,Inhibitory concentration against IKr potassium channel,COc1ccc(CCN2CCC(Nc3nc4ccccc4n3Cc3ccc(F)cc3)CC2)cc1,Bioorg Med Chem Lett,CHEMBL296419,0.0015,Yes,8.823908741
CHEMBL827807,Inhibitory concentration against IKr potassium channel,CS(=O)(=O)Nc1ccc2c(c1)C(=O)CC1(CCN(CCc3ccc4nonc4c3)CC1)O2,Bioorg Med Chem Lett,CHEMBL129583,0.008,Yes,8.096910013
CHEMBL827807,Inhibitory concentration against IKr potassium channel,CCCCCCCN(CC)CCCCc1ccc([N+](=O)[O-])cc1,Bioorg Med Chem Lett,CHEMBL182977,0.01,Yes,8
CHEMBL827807,Inhibitory concentration against IKr potassium channel,CCCCCCCN(CC)CCCC(O)c1ccc(NS(C)(=O)=O)cc1,Bioorg Med Chem Lett,CHEMBL533,0.02,Yes,7.698970004
CHEMBL827807,Inhibitory concentration against IKr potassium channel,COc1ccc(CCN(C)CCCN(C(=O)c2ccc([N+](=O)[O-])cc2)c2ccc(OC)c(OC)c2)cc1OC,Bioorg Med Chem Lett,CHEMBL182646,0.02,Yes,7.698970004
CHEMBL827807,Inhibitory concentration against IKr potassium channel,Cc1cccc(CCN2CCC(C(=O)c3ccc(NS(C)(=O)=O)cc3)CC2)n1,Bioorg Med Chem Lett,CHEMBL327980,0.02,Yes,7.698970004
CHEMBL827807,Inhibitory concentration against IKr potassium channel,COc1ccc(C2CCN(CC[C@H]3CCOc4ccccc43)CC2)cc1OC,Bioorg Med Chem Lett,CHEMBL96153,0.03,Yes,7.522878745
CHEMBL827807,Inhibitory concentration against IKr potassium channel,CN(CCOc1ccc(NS(C)(=O)=O)cc1)CCc1ccc(NS(C)(=O)=O)cc1,Bioorg Med Chem Lett,CHEMBL473,0.03,Yes,7.522878745
CHEMBL827807,Inhibitory concentration against IKr potassium channel,CC(C)(C)c1ccc(C(O)CCCN2CCC(C(O)(c3ccccc3)c3ccccc3)CC2)cc1,Bioorg Med Chem Lett,CHEMBL17157,0.05,Yes,7.301029996
CHEMBL827807,Inhibitory concentration against IKr potassium channel,CCCCCCC[N+](CC)(CC)CCCCc1ccc(Cl)cc1,Bioorg Med Chem Lett,CHEMBL9484,0.15,Yes,6.823908741
CHEMBL827807,Inhibitory concentration against IKr potassium channel,CCC[S+]([O-])CCCN(CC)CC(O)COc1ccc(C#N)cc1,Bioorg Med Chem Lett,CHEMBL362103,0.25,Yes,6.602059991
CHEMBL827807,Inhibitory concentration against IKr potassium channel,Cc1nc2n(c(=O)c1CCN1CCC(c3noc4cc(F)ccc34)CC1)CCCC2,Bioorg Med Chem Lett,CHEMBL85,0.26,Yes,6.585026652
CHEMBL827807,Inhibitory concentration against IKr potassium channel,COc1ccccc1OCCNCC(O)COc1cccc2[nH]c3ccccc3c12,Bioorg Med Chem Lett,CHEMBL723,0.35,Yes,6.455931956
CHEMBL827807,Inhibitory concentration against IKr potassium channel,CN1CCN(CCCCN2C(=O)CN(/N=C/c3ccc(-c4ccc(Cl)cc4)o3)C2=O)CC1,Bioorg Med Chem Lett,CHEMBL123558,0.4,Yes,6.397940009
CHEMBL827807,Inhibitory concentration against IKr potassium channel,CC(C)COCC(CN(Cc1ccccc1)c1ccccc1)N1CCCC1,Bioorg Med Chem Lett,CHEMBL1008,0.43,Yes,6.366531544
CHEMBL827807,Inhibitory concentration against IKr potassium channel,CC(CC(c1ccccc1)c1ccccc1)NC(C)(C)C,Bioorg Med Chem Lett,CHEMBL363295,0.5,Yes,6.301029996
CHEMBL827807,Inhibitory concentration against IKr potassium channel,CCCNCC(O)COc1ccccc1C(=O)CCc1ccccc1,Bioorg Med Chem Lett,CHEMBL631,0.8,Yes,6.096910013
CHEMBL827807,Inhibitory concentration against IKr potassium channel,CCN(CC)CCNC(=O)c1ccc(NC(C)=O)cc1,Bioorg Med Chem Lett,CHEMBL1097,100,No,4
CHEMBL827807,Inhibitory concentration against IKr potassium channel,COC(=O)C1=C(C)NC(C)=C(C(=O)OC)C1c1ccccc1[N+](=O)[O-],Bioorg Med Chem Lett,CHEMBL193,280,No,3.552841969
CHEMBL827807,Inhibitory concentration against IKr potassium channel,CCCC(C)C1(CC)C(=O)NC(=O)NC1=O,Bioorg Med Chem Lett,CHEMBL448,22800,No,1.642065153
CHEMBL827807,Inhibitory concentration against IKr potassium channel,CCCCN(CCCC)CCC(O)c1cc2c(Cl)cc(Cl)cc2c2cc(C(F)(F)F)ccc12,Bioorg Med Chem Lett,CHEMBL1107,0.04,Yes,7.397940009
CHEMBL827807,Inhibitory concentration against IKr potassium channel,CN1Cc2ccccc2[C@@H](c2ccccc2)N=C1CCc1ccccc1,Bioorg Med Chem Lett,CHEMBL362721,0.09,Yes,7.045757491
CHEMBL827807,Inhibitory concentration against IKr potassium channel,COc1ccc(CCNCCCNC(=O)c2ccc([N+](=O)[O-])cc2)cc1OC,Bioorg Med Chem Lett,CHEMBL184461,0.42,Yes,6.37675071
CHEMBL829261,Inhibition of human Potassium channel HERG,NC(CC(=O)N1CCC[C@H]1C(=O)NCc1ccc(C(=O)O)cc1)Cc1ccc(F)c(F)c1.O=C(O)C(F)(F)F,Bioorg Med Chem Lett,CHEMBL182223,79,No,4.102372909
CHEMBL829261,Inhibition of human Potassium channel HERG,NC(CC(=O)N1CCC[C@H]1C(=O)NCc1ccc(C(F)(F)F)cc1)Cc1ccccc1F.O=C(O)C(F)(F)F,Bioorg Med Chem Lett,CHEMBL435882,0.87,Yes,6.060480747
CHEMBL829261,Inhibition of human Potassium channel HERG,CC(C)[C@@H](Oc1ccc(CNC(=O)[C@@H]2CCCN2C(=O)CC(N)Cc2cc(F)ccc2F)cc1)C(=O)O.O=C(O)C(F)(F)F,Bioorg Med Chem Lett,CHEMBL364102,76,No,4.119186408
CHEMBL827842,Inhibitory activity against human Potassium channel HERG,NCc1ccc(F)c(C2CCN(C(=O)c3cccc(-c4nc(-c5cccs5)no4)c3)CC2)c1,Bioorg Med Chem Lett,CHEMBL186730,0.8,Yes,6.096910013
CHEMBL827842,Inhibitory activity against human Potassium channel HERG,NCc1ccc(F)c(C2CCN(C(=O)c3cc(C(=O)O)cc(-c4nc(-c5cccs5)no4)c3)CC2)c1,Bioorg Med Chem Lett,CHEMBL188068,76.8,No,4.11463878
CHEMBL829377,Inhibitory concentration against Potassium channel HERG was determined,C[C@@H](c1ccc(-c2cccc(-c3nn[nH]n3)c2)cc1)[C@H](N)C(=O)N1CC[C@H](F)C1.O=C(O)C(F)(F)F,Bioorg Med Chem Lett,CHEMBL195378,59,No,4.229147988
CHEMBL828008,Mean inhibitory concentration against potassium channel HERG,COc1ccc([C@@H](O)C[C@H]2c3cc(OC)c(OC)cc3CCN2C)cc1,Bioorg Med Chem Lett,CHEMBL196983,0.79,Yes,6.102372909
CHEMBL828008,Mean inhibitory concentration against potassium channel HERG,COc1cc2c(cc1OC)[C@H](C[C@H](O)c1ccc(Cl)cc1)N(C)CC2,Bioorg Med Chem Lett,CHEMBL197467,0.4,Yes,6.397940009
CHEMBL827704,In vitro inhibitory concentration against displacement of 35[S] MK-499 binding to hERG channel expressed in HEK293 cells,COc1cccc(CN2CCCCCCC2)c1OCc1csc(-c2ccccc2)n1,Bioorg Med Chem Lett,CHEMBL197243,0.18,Yes,6.744727495
CHEMBL827704,In vitro inhibitory concentration against displacement of 35[S] MK-499 binding to hERG channel expressed in HEK293 cells,COc1cccc(CN2CCCCCCC2)c1OCc1csc(-c2ccc(Cl)cc2)n1,Bioorg Med Chem Lett,CHEMBL197304,0.04,Yes,7.397940009
CHEMBL827704,In vitro inhibitory concentration against displacement of 35[S] MK-499 binding to hERG channel expressed in HEK293 cells,Clc1ccc(-c2nc(COc3ccccc3CN3CCCCCCC3)cs2)cc1,Bioorg Med Chem Lett,CHEMBL195180,0.03,Yes,7.522878745
CHEMBL829152,Inhibitory concentration against potassium channel HERG,COc1ccc(CCN2CCC(Nc3nc4ccccc4n3Cc3ccc(F)cc3)CC2)cc1,Bioorg Med Chem Lett,CHEMBL296419,0.01,Yes,8
CHEMBL829152,Inhibitory concentration against potassium channel HERG,CN(CCOc1ccc(NS(C)(=O)=O)cc1)CCc1ccc(NS(C)(=O)=O)cc1,Bioorg Med Chem Lett,CHEMBL473,0.01,Yes,8
CHEMBL829152,Inhibitory concentration against potassium channel HERG,O=C1NCCN1CCN1CCC(c2cn(-c3ccc(F)cc3)c3ccc(Cl)cc23)CC1,Bioorg Med Chem Lett,CHEMBL12713,0.01,Yes,8
CHEMBL829152,Inhibitory concentration against potassium channel HERG,CCCCCCCN(CC)CCCC(O)c1ccc(NS(C)(=O)=O)cc1,Bioorg Med Chem Lett,CHEMBL533,0.01,Yes,8
CHEMBL829152,Inhibitory concentration against potassium channel HERG,Cc1cccc(C)c1NC(=O)CN1CCN(CCCC(c2ccc(F)cc2)c2ccc(F)cc2)CC1,Bioorg Med Chem Lett,CHEMBL92870,0.01585,Yes,7.799970733
CHEMBL829152,Inhibitory concentration against potassium channel HERG,Cc1ccc(O)c([C@H](CCN(C(C)C)C(C)C)c2ccccc2)c1,Bioorg Med Chem Lett,CHEMBL1382,0.01698,Yes,7.770062314
CHEMBL829152,Inhibitory concentration against potassium channel HERG,Cc1cccc(CCN2CCC(C(=O)c3ccc(NS(C)(=O)=O)cc3)CC2)n1,Bioorg Med Chem Lett,CHEMBL327980,0.01995,Yes,7.7000571
CHEMBL829152,Inhibitory concentration against potassium channel HERG,O=C(CCCN1CCC(O)(c2ccc(Cl)cc2)CC1)c1ccc(F)cc1,Bioorg Med Chem Lett,CHEMBL54,0.0302,Yes,7.519993057
CHEMBL829152,Inhibitory concentration against potassium channel HERG,O=C(CCCN1CC=C(n2c(=O)[nH]c3ccccc32)CC1)c1ccc(F)cc1,Bioorg Med Chem Lett,CHEMBL1108,0.03236,Yes,7.489991487
CHEMBL829152,Inhibitory concentration against potassium channel HERG,COc1cc(N)c(Cl)cc1C(=O)NC1CCN(CCCOc2ccc(F)cc2)CC1OC,Bioorg Med Chem Lett,CHEMBL1729,0.03981,Yes,7.400007822
CHEMBL829152,Inhibitory concentration against potassium channel HERG,O=c1[nH]c2ccccc2n1C1CCN(CCCC(c2ccc(F)cc2)c2ccc(F)cc2)CC1,Bioorg Med Chem Lett,CHEMBL1423,0.05012,Yes,7.299988938
CHEMBL829152,Inhibitory concentration against potassium channel HERG,O=C1Cc2cc(CCN3CCN(c4nsc5ccccc45)CC3)c(Cl)cc2N1,Bioorg Med Chem Lett,CHEMBL708,0.12023,Yes,6.919987153
CHEMBL829152,Inhibitory concentration against potassium channel HERG,COc1ccc(CCN(C)CCCC(C#N)(c2ccc(OC)c(OC)c2)C(C)C)cc1OC,Bioorg Med Chem Lett,CHEMBL6966,0.14125,Yes,6.850011544
CHEMBL829152,Inhibitory concentration against potassium channel HERG,Cc1nc2n(c(=O)c1CCN1CCC(C3NOc4cc(F)ccc43)CC1)CCCC2,Bioorg Med Chem Lett,CHEMBL364512,0.15136,Yes,6.819988881
CHEMBL829152,Inhibitory concentration against potassium channel HERG,O=c1[nH]c2ccccc2n1CCCN1CCC(n2c(=O)[nH]c3cc(Cl)ccc32)CC1,Bioorg Med Chem Lett,CHEMBL219916,0.16218,Yes,6.790002704
CHEMBL829152,Inhibitory concentration against potassium channel HERG,CCOC(=O)N1CCC(=C2c3ccc(Cl)cc3CCc3cccnc32)CC1,Bioorg Med Chem Lett,CHEMBL998,0.16982,Yes,6.770011163
CHEMBL829152,Inhibitory concentration against potassium channel HERG,Cc1cc2c(s1)Nc1ccccc1N=C2N1CCN(C)CC1,Bioorg Med Chem Lett,CHEMBL715,0.18197,Yes,6.740000205
CHEMBL829152,Inhibitory concentration against potassium channel HERG,CSc1ccc2c(c1)N(CCC1CCCCN1C)c1ccccc1S2,Bioorg Med Chem Lett,CHEMBL479,0.19055,Yes,6.719991047
CHEMBL829152,Inhibitory concentration against potassium channel HERG,CC(C)(C)c1ccc(C(O)CCCN2CCC(C(O)(c3ccccc3)c3ccccc3)CC2)cc1,Bioorg Med Chem Lett,CHEMBL17157,0.19953,Yes,6.699991797
CHEMBL829152,Inhibitory concentration against potassium channel HERG,CCCCN(CCCC)CCC(O)c1cc2c(Cl)cc(Cl)cc2c2cc(C(F)(F)F)ccc12,Bioorg Med Chem Lett,CHEMBL1107,0.19953,Yes,6.699991797
CHEMBL829152,Inhibitory concentration against potassium channel HERG,COc1ccc(C2CCN(CC[C@H]3CCOc4ccccc43)CC2)cc1OC,Bioorg Med Chem Lett,CHEMBL96153,0.25119,Yes,6.599997654
CHEMBL829152,Inhibitory concentration against potassium channel HERG,C=C[C@H]1CN2CC[C@H]1C[C@@H]2[C@@H](O)c1ccnc2ccc(OC)cc12,Bioorg Med Chem Lett,CHEMBL1294,0.32359,Yes,6.490004908
CHEMBL829152,Inhibitory concentration against potassium channel HERG,CCOC(=O)C1(c2ccccc2)CCN(C)CC1,Bioorg Med Chem Lett,CHEMBL607,0.32359,Yes,6.490004908
CHEMBL829152,Inhibitory concentration against potassium channel HERG,CN1CCN(C2=Nc3cc(Cl)ccc3Nc3ccccc32)CC1,Bioorg Med Chem Lett,CHEMBL42,0.32359,Yes,6.490004908
CHEMBL829152,Inhibitory concentration against potassium channel HERG,CN(c1nccc(=O)[nH]1)C1CCN(c2nc3ccccc3n2Cc2ccc(F)cc2)CC1,Bioorg Med Chem Lett,CHEMBL94454,0.43652,Yes,6.359995853
CHEMBL829152,Inhibitory concentration against potassium channel HERG,CN1CCCCC1CCN1c2ccccc2Sc2ccc([S+](C)[O-])cc21,Bioorg Med Chem Lett,CHEMBL1088,0.54954,Yes,6.260000691
CHEMBL829152,Inhibitory concentration against potassium channel HERG,CC(C)COCC(CN(Cc1ccccc1)c1ccccc1)N1CCCC1,Bioorg Med Chem Lett,CHEMBL1008,0.54954,Yes,6.260000691
CHEMBL829152,Inhibitory concentration against potassium channel HERG,Cc1nccn1CC1CCc2c(c3ccccc3n2C)C1=O,Bioorg Med Chem Lett,CHEMBL46,0.81283,Yes,6.090000276
CHEMBL829152,Inhibitory concentration against potassium channel HERG,O=C(O)COCCN1CCN(C(c2ccccc2)c2ccc(Cl)cc2)CC1,Bioorg Med Chem Lett,CHEMBL1000,30.19952,No,4.51999996
CHEMBL829152,Inhibitory concentration against potassium channel HERG,Cc1c(F)c(N2CCNC(C)C2)cc2c1c(=O)c(C(=O)O)cn2C1CC1,Bioorg Med Chem Lett,CHEMBL583,50.11872,No,4.300000029
CHEMBL829152,Inhibitory concentration against potassium channel HERG,COC(=O)C1=C(C)NC(C)=C(C(=O)OC)C1c1ccccc1[N+](=O)[O-],Bioorg Med Chem Lett,CHEMBL193,50.11872,No,4.300000029
CHEMBL829152,Inhibitory concentration against potassium channel HERG,C/C=C1/N(C)C(C)CC1(c1ccccc1)c1ccccc1,Bioorg Med Chem Lett,CHEMBL196431,50.11872,No,4.300000029
CHEMBL829152,Inhibitory concentration against potassium channel HERG,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(OC)C[C@@H](C)C(=O)[C@H](C)[C@@H](O)[C@]1(C)O,Bioorg Med Chem Lett,CHEMBL1741,58.88437,No,4.229999967
CHEMBL829152,Inhibitory concentration against potassium channel HERG,CC(C)N(CCC(C(N)=O)(c1ccccc1)c1ccccn1)C(C)C,Bioorg Med Chem Lett,CHEMBL517,91.20108,No,4.040000019
CHEMBL829152,Inhibitory concentration against potassium channel HERG,NC1=NCC2c3ccccc3Cc3ccccc3N12,Bioorg Med Chem Lett,CHEMBL1106,91.20108,No,4.040000019
CHEMBL829152,Inhibitory concentration against potassium channel HERG,COc1c(N2C[C@@H]3CCCN[C@@H]3C2)c(F)cc2c(=O)c(C(=O)O)cn(C3CC3)c12,Bioorg Med Chem Lett,CHEMBL32,128.82496,No,3.889999984
CHEMBL829152,Inhibitory concentration against potassium channel HERG,COc1c(N2CCNC(C)C2)c(F)cc2c(=O)c(C(=O)O)cn(C3CC3)c12,Bioorg Med Chem Lett,CHEMBL31,128.82496,No,3.889999984
CHEMBL829152,Inhibitory concentration against potassium channel HERG,CCN(CC)CCNC(=O)c1ccc(N)cc1,Bioorg Med Chem Lett,CHEMBL640,138.03843,No,3.859999989
CHEMBL829152,Inhibitory concentration against potassium channel HERG,CN1CCC[C@H]1c1cccnc1,Bioorg Med Chem Lett,CHEMBL3,245.47089,No,3.610000003
CHEMBL829152,Inhibitory concentration against potassium channel HERG,COc1ccc2c3c1O[C@H]1[C@@H](O)C=C[C@H]4[C@@H](C2)N(C)CC[C@@]341,Bioorg Med Chem Lett,CHEMBL485,301.99517,No,3.520000003
CHEMBL829152,Inhibitory concentration against potassium channel HERG,C[C@H]1COc2c(N3CCN(C)CC3)c(F)cc3c(=O)c(C(=O)O)cn1c23,Bioorg Med Chem Lett,CHEMBL33,912.01084,No,3.04
CHEMBL829152,Inhibitory concentration against potassium channel HERG,O=C(O)c1cn(C2CC2)c2cc(N3CCNCC3)c(F)cc2c1=O,Bioorg Med Chem Lett,CHEMBL8,954.99259,No,3.019999998
CHEMBL829152,Inhibitory concentration against potassium channel HERG,CN1CC[C@]23c4c5ccc(O)c4O[C@H]2[C@@H](O)C=C[C@H]3[C@H]1C5,Bioorg Med Chem Lett,CHEMBL70,1000,No,3
CHEMBL829152,Inhibitory concentration against potassium channel HERG,CC1COc2c(N3CCN(C)CC3)c(F)cc3c(=O)c(C(=O)O)cn1c23,Bioorg Med Chem Lett,CHEMBL4,1412.53754,No,2.850000001
CHEMBL865567,Inhibition of hERG potassium channel expressed in CHO cells by whole cell patch clamp method,C[C@@H]1CNC[C@H]2Cc3ccc(Cl)nc3N21,Bioorg Med Chem Lett,CHEMBL203230,40,No,4.397940009
CHEMBL869626,Inhibitory activity against human hERG receptor expressed in HEK cells,CN(C)C(=O)N1CC(c2cc(F)ccc2F)=C[C@H]1c1cccc(O)c1,Bioorg Med Chem Lett,CHEMBL381533,33,No,4.48148606
CHEMBL853270,Inhibition of hERG potassium channel in HEK293 cells by patch clamp assay,COc1ccc(CCN2CCC(Nc3nc4ccccc4n3Cc3ccc(F)cc3)CC2)cc1,J Med Chem,CHEMBL296419,0.0009,Yes,9.045757491
CHEMBL853270,Inhibition of hERG potassium channel in HEK293 cells by patch clamp assay,CC(=O)Nc1cccc(N2CCN(CCCCNS(=O)(=O)c3ccc(C)cc3)CC2)c1,J Med Chem,CHEMBL210537,0.3,Yes,6.522878745
CHEMBL869841,Inhibition of hERG channel by voltage clamp assay,CN1CCN(CCCN(C(=O)Nc2ccc(F)c(C(F)(F)F)c2)[C@@H]2CC[C@]3(c4ccc(C#N)cc4)C[C@H]23)CC1,Bioorg Med Chem Lett,CHEMBL205285,0.052,Yes,7.283996656
CHEMBL869841,Inhibition of hERG channel by voltage clamp assay,CN1CCN(CCCN(C(=O)Nc2ccc(F)c(C(F)(F)F)c2)[C@@H]2CC[C@]3(c4ccc5c(N)noc5c4)C[C@H]23)CC1,Bioorg Med Chem Lett,CHEMBL209964,0.69,Yes,6.161150909
CHEMBL869869,Inhibition of HERG potassium channel expressed in HEK cells by whole cell patch clamp method,CN(C(=O)c1ccc(-c2ccc(C(F)(F)F)cc2)cc1)[C@H]1CCN(C(=O)N(C)[C@@H]2CCN(CCCc3ccc(Cl)cc3)C2)C1,Bioorg Med Chem Lett,CHEMBL375330,0.17,Yes,6.769551079
CHEMBL909940,Displacement of [3H]dofetilide from hERG,COc1ccc2c(=O)cc(C(=O)NC3CCN(Cc4ccc5c(c4)OCO5)CC3)oc2c1,J Med Chem,CHEMBL206081,0.0115,Yes,7.93930216
CHEMBL909940,Displacement of [3H]dofetilide from hERG,N#Cc1ccc2c(=O)cc(C(=O)NC3CCN(Cc4ccc5c(c4)OCO5)CC3)oc2c1,J Med Chem,CHEMBL387417,0.005,Yes,8.301029996
CHEMBL909940,Displacement of [3H]dofetilide from hERG,O=C(NC1CCN(Cc2ccc3c(c2)OCO3)CC1)c1cc(=O)c2ccc(F)cc2o1,J Med Chem,CHEMBL214021,0.0151,Yes,7.821023053
CHEMBL909940,Displacement of [3H]dofetilide from hERG,O=C(NC1CCN(Cc2ccc3c(c2)OCO3)CC1)c1cc(=O)c2ccc(Cl)cc2o1,J Med Chem,CHEMBL217789,0.0036,Yes,8.443697499
CHEMBL909940,Displacement of [3H]dofetilide from hERG,O=C(NC1CCN(Cc2ccc3c(c2)OCO3)CC1)c1cc(=O)c2ccc(Br)cc2o1,J Med Chem,CHEMBL217706,0.0025,Yes,8.602059991
CHEMBL909940,Displacement of [3H]dofetilide from hERG,CCc1ccc2c(=O)cc(C(=O)NC3CCN(Cc4ccc5c(c4)OCO5)CC3)oc2c1,J Med Chem,CHEMBL214377,0.0074,Yes,8.13076828
CHEMBL909940,Displacement of [3H]dofetilide from hERG,O=C(NC1CCN(Cc2ccc3c(c2)OCO3)CC1)c1cc(=O)c2ccc(OC(F)F)cc2o1,J Med Chem,CHEMBL213715,0.0036,Yes,8.443697499
CHEMBL909940,Displacement of [3H]dofetilide from hERG,O=C(NC1CCN(Cc2ccc3c(c2)OCO3)CC1)c1cc(=O)c2ccc(O)cc2o1,J Med Chem,CHEMBL215631,0.0637,Yes,7.195860568
CHEMBL909940,Displacement of [3H]dofetilide from hERG,O=C(NC1CCN(Cc2ccc3c(c2)OCO3)CC1)c1cc(=O)c2cc(F)ccc2o1,J Med Chem,CHEMBL214731,0.004,Yes,8.397940009
CHEMBL909940,Displacement of [3H]dofetilide from hERG,O=C(NC1CCN(Cc2ccc3c(c2)OCO3)CC1)c1cc(=O)c2cc(F)c(F)cc2o1,J Med Chem,CHEMBL387178,0.0062,Yes,8.207608311
CHEMBL909940,Displacement of [3H]dofetilide from hERG,COc1cc2oc(C(=O)NC3CCN(Cc4ccc5c(c4)OCO5)CC3)cc(=O)c2cc1F,J Med Chem,CHEMBL217442,0.0159,Yes,7.798602876
CHEMBL909940,Displacement of [3H]dofetilide from hERG,O=C(NC1CCN(Cc2ccc3c(c2)OCO3)CC1)c1cc(=O)c2cc(F)c(Cl)cc2o1,J Med Chem,CHEMBL387418,0.0105,Yes,7.978810701
CHEMBL909940,Displacement of [3H]dofetilide from hERG,O=C(NC1CCN(Cc2ccc3c(c2)OCO3)CC1)c1cc(=O)c2ccccc2o1,J Med Chem,CHEMBL214767,0.0067,Yes,8.173925197
CHEMBL909940,Displacement of [3H]dofetilide from hERG,O=C(NC1CCN(Cc2ccc3c(c2)OCO3)CC1)c1cc(=O)c2cc(Cl)c(Cl)cc2o1,J Med Chem,CHEMBL204828,0.0014,Yes,8.853871964
CHEMBL909940,Displacement of [3H]dofetilide from hERG,O=C(NC1CCN(Cc2ccccc2)CC1)c1cc(=O)c2ccc(F)cc2o1,J Med Chem,CHEMBL213761,0.0199,Yes,7.701146924
CHEMBL909940,Displacement of [3H]dofetilide from hERG,O=C(NC1CCN(Cc2ccc3c(c2)OC(F)(F)O3)CC1)c1cc(=O)c2ccc(F)cc2o1,J Med Chem,CHEMBL217707,0.0056,Yes,8.251811973
CHEMBL909940,Displacement of [3H]dofetilide from hERG,CC(=O)Nc1ccc(CN2CCC(NC(=O)c3cc(=O)c4ccc(F)cc4o3)CC2)cc1,J Med Chem,CHEMBL216680,0.0477,Yes,7.321481621
CHEMBL909940,Displacement of [3H]dofetilide from hERG,CC(=O)c1ccc(CN2CCC(NC(=O)c3cc(=O)c4ccc(F)cc4o3)CC2)cc1,J Med Chem,CHEMBL384487,0.0203,Yes,7.692503962
CHEMBL909940,Displacement of [3H]dofetilide from hERG,COc1ccc(CN2CCC(NC(=O)c3cc(=O)c4ccc(F)cc4o3)CC2)cc1F,J Med Chem,CHEMBL214768,0.0085,Yes,8.070581074
CHEMBL909940,Displacement of [3H]dofetilide from hERG,COc1ccc(CN2CCC(NC(=O)c3cc(=O)c4ccc(F)cc4o3)CC2)c(F)c1,J Med Chem,CHEMBL387309,0.0147,Yes,7.832682665
CHEMBL909940,Displacement of [3H]dofetilide from hERG,O=C(NC1CCN(Cc2cccc(F)c2)CC1)c1cc(=O)c2ccc(F)cc2o1,J Med Chem,CHEMBL216225,0.0212,Yes,7.673664139
CHEMBL909940,Displacement of [3H]dofetilide from hERG,COc1ccc(CN2CCC(NC(=O)c3cc(=O)c4ccc(F)cc4o3)CC2)cc1,J Med Chem,CHEMBL217593,0.0054,Yes,8.26760624
CHEMBL909940,Displacement of [3H]dofetilide from hERG,COc1cccc(CN2CCC(NC(=O)c3cc(=O)c4ccc(F)cc4o3)CC2)c1,J Med Chem,CHEMBL217400,0.0104,Yes,7.982966661
CHEMBL909940,Displacement of [3H]dofetilide from hERG,O=C(NC1CCN(Cc2ccc3c(c2)OCCO3)CC1)c1cc(=O)c2ccc(F)cc2o1,J Med Chem,CHEMBL425448,0.0122,Yes,7.913640169
CHEMBL909940,Displacement of [3H]dofetilide from hERG,O=C(NC1CCN(Cc2cc3c(cc2Cl)OCO3)CC1)c1cc(=O)c2ccc(F)cc2o1,J Med Chem,CHEMBL217105,0.0135,Yes,7.869666232
CHEMBL908975,Binding affinity to hERG potassium channel,COc1ccc2c(=O)n(CC(O)CO)c(C#N)c(-c3cccc(F)c3)c2c1,J Med Chem,CHEMBL215023,33.5,No,4.474955193
CHEMBL908975,Binding affinity to hERG potassium channel,COc1ccc2c(=O)n(C[C@@H](O)CO)c(C#N)c(-c3ccccc3)c2c1,J Med Chem,CHEMBL217571,76,No,4.119186408
CHEMBL908975,Binding affinity to hERG potassium channel,COc1ccc2c(=O)n(C[C@H](O)CO)c(C#N)c(-c3ccccc3)c2c1,J Med Chem,CHEMBL216894,135,No,3.869666232
CHEMBL908975,Binding affinity to hERG potassium channel,COc1ccc2c(=O)n(CCO)c(C#N)c(-c3cccc(F)c3)c2c1,J Med Chem,CHEMBL214969,62,No,4.207608311
CHEMBL854890,Displacement of 3H-dofetilide from hERG-expressing HEK membrane homogenates,O=C(NC1CCN(Cc2ccc3ncoc3c2)CC1)c1cc(=O)c2ccc(F)cc2o1,Bioorg Med Chem Lett,CHEMBL216524,34.6,No,4.460923901
CHEMBL854890,Displacement of 3H-dofetilide from hERG-expressing HEK membrane homogenates,O=C(NC1CCN(Cc2ccc3oc(=O)oc3c2)CC1)c1cc(=O)c2ccc(F)cc2o1,Bioorg Med Chem Lett,CHEMBL216323,85.2,No,4.069560405
CHEMBL854890,Displacement of 3H-dofetilide from hERG-expressing HEK membrane homogenates,O=C(NC1CCN(Cc2ccc3ccc(=O)[nH]c3c2)CC1)c1cc(=O)c2ccc(F)cc2o1,Bioorg Med Chem Lett,CHEMBL216482,85.5,No,4.068033885
CHEMBL854890,Displacement of 3H-dofetilide from hERG-expressing HEK membrane homogenates,Cn1c(=O)ccc2ccc(CN3CCC(NC(=O)c4cc(=O)c5ccc(F)cc5o4)CC3)cc21,Bioorg Med Chem Lett,CHEMBL266725,47.4,No,4.324221658
CHEMBL854890,Displacement of 3H-dofetilide from hERG-expressing HEK membrane homogenates,O=C(NC1CCN(Cc2ccc3ccc(=O)oc3c2)CC1)c1cc(=O)c2ccc(F)cc2o1,Bioorg Med Chem Lett,CHEMBL386281,51.1,No,4.2915791
CHEMBL854890,Displacement of 3H-dofetilide from hERG-expressing HEK membrane homogenates,CC(=O)Nc1ccc(CN2CCC(NC(=O)c3cc(=O)c4ccc(F)cc4o3)CC2)cc1,Bioorg Med Chem Lett,CHEMBL216680,47.7,No,4.321481621
CHEMBL854890,Displacement of 3H-dofetilide from hERG-expressing HEK membrane homogenates,CC(=O)Nc1cccc(CN2CCC(NC(=O)c3cc(=O)c4ccc(F)cc4o3)CC2)c1,Bioorg Med Chem Lett,CHEMBL269352,60.7,No,4.216811309
CHEMBL854891,Displacement of 3H-dofetilide from hERG-expressing HEK membrane homogenates,CC(=O)Nc1ccc2c(c1)C(N1CCC(NC(=O)c3cc(=O)c4ccc(F)cc4o3)CC1)CC2,Bioorg Med Chem Lett,CHEMBL215661,34.8,No,4.458420756
CHEMBL855968,Inhibition of hERG potassium channel,C[C@H](c1nc(-c2ccc(Cl)cc2Cl)no1)[C@H](N)C(=O)N1CCCC1.O=C(O)C(F)(F)F,Bioorg Med Chem Lett,CHEMBL438992,36.7,No,4.435333936
CHEMBL855968,Inhibition of hERG potassium channel,CS(=O)(=O)c1ccc(-c2noc([C@@H](CC3CC3)[C@H](N)C(=O)N3CC[C@H](F)C3)n2)c(F)c1.O=C(O)C(F)(F)F,Bioorg Med Chem Lett,CHEMBL375745,58.5,No,4.232844134
CHEMBL907269,Inhibition of human ERG potassium channel in HEK293 cells by patch clamp assay,CC(C)(C)c1ccc(C(O)CCCN2CCC(C(O)(c3ccccc3)c3ccccc3)CC2)cc1,Bioorg Med Chem Lett,CHEMBL17157,56,No,4.251811973
CHEMBL856827,Displacement of [35S]MK-499 from hERG potassium channel expressed in HEK293 cells,c1ccc(COc2ccc(CCNc3ccncc3)cc2)cc1,J Med Chem,CHEMBL48029,0.13,Yes,6.886056648
CHEMBL914755,Displacement of [3H]dofetilide from hERG expressed in HEK293 cells,CN1CCN(Cc2ccc3c(c2)Cc2c(-c4csc(C#CCCOc5ccccc5)c4)n[nH]c2-3)CC1,J Med Chem,CHEMBL225090,0.45,Yes,6.346787486
CHEMBL914755,Displacement of [3H]dofetilide from hERG expressed in HEK293 cells,CN1CCN(Cc2ccc3c(c2)Cc2c(-c4csc(C#CCOc5ccccc5Cl)c4)n[nH]c2-3)CC1,J Med Chem,CHEMBL225318,0.79,Yes,6.102372909
CHEMBL914755,Displacement of [3H]dofetilide from hERG expressed in HEK293 cells,CC1CCN(Cc2ccc3c(c2)Cc2c(-c4csc(C#CCOc5ccccc5)c4)n[nH]c2-3)CC1,J Med Chem,CHEMBL387972,0.08,Yes,7.096910013
CHEMBL914758,Inhibition of hERG expressed in HEK293 cells assessed as effect on ionic current by patch clamp assay,CN1CCN(Cc2ccc3c(c2)Cc2c(-c4csc(C#CCOc5ccccc5)c4)n[nH]c2-3)C(=O)C1,J Med Chem,CHEMBL225334,53,No,4.27572413
CHEMBL889312,Blockade of hERG expressed in HEK293 cells by whole-cell patch clamp method,CN(CCOc1ccc(NS(C)(=O)=O)cc1)CCc1ccc(NS(C)(=O)=O)cc1,J Med Chem,CHEMBL473,0.0092,Yes,8.036212173
CHEMBL889312,Blockade of hERG expressed in HEK293 cells by whole-cell patch clamp method,CC1(C)C2=C3CC4C5=[N+](CCC4OC3CCN2c2ccc(CC(=O)NCCCCCCN(CCOc3ccc(NS(C)(=O)=O)cc3)CCc3ccc(NS(C)(=O)=O)cc3)cc21)c1ccc(S(=O)(=O)[O-])cc1C5(C)C,J Med Chem,CHEMBL227000,0.31,Yes,6.508638306
CHEMBL888509,Inhibition of human ERG potassium channel,Cc1cc(=O)n2nc(N3CC[C@H](c4cc(F)c(F)cc4F)[C@@H](N)C3)ccc2n1.O=C(O)C(F)(F)F,Bioorg Med Chem Lett,CHEMBL231397,33.2,No,4.478861916
CHEMBL888509,Inhibition of human ERG potassium channel,N[C@H]1CN(c2ccc3nc(=O)ccn3n2)CC[C@@H]1c1cc(F)c(F)cc1F.O=C(O)C(F)(F)F,Bioorg Med Chem Lett,CHEMBL231396,100,No,4
CHEMBL888509,Inhibition of human ERG potassium channel,N[C@H]1CN(c2ccn3cnnc3n2)CC[C@@H]1c1cc(F)c(F)cc1F.O=C(O)C(F)(F)F,Bioorg Med Chem Lett,CHEMBL231294,100,No,4
CHEMBL895731,Inhibition of hERG,CN(C(=O)CC[C@@H](C1CCCCC1)N1Cc2cc(Oc3ccccc3)ccc2N=C1N)C1CCCCC1,J Med Chem,CHEMBL244347,0.14,Yes,6.853871964
CHEMBL895464,Displacement of [3H]dofetilide from hERG expressed in CHO cells,Cc1cc(-c2ccc3c(c2)CCN(CCSc2nnc(-c4ccc(F)c(F)c4)n2C)CC3)n(C)n1,J Med Chem,CHEMBL242602,0.50119,Yes,6.299997603
CHEMBL895464,Displacement of [3H]dofetilide from hERG expressed in CHO cells,Cc1cc(-c2ccc3c(c2)CCN(CCCSc2nnc(-c4ccc(C(F)(F)F)cc4)n2C)CC3)n(C)n1,J Med Chem,CHEMBL390649,0.03162,Yes,7.500038134
CHEMBL895464,Displacement of [3H]dofetilide from hERG expressed in CHO cells,Cc1cc(-c2ccc3c(c2)CCN(CCCSc2nnc(-c4ccc(F)c(F)c4)n2C)CC3)n(C)n1,J Med Chem,CHEMBL245118,0.25119,Yes,6.599997654
CHEMBL895464,Displacement of [3H]dofetilide from hERG expressed in CHO cells,COc1ccc(-c2nnc(SCCCN3CCc4ccc(-c5cc(C)on5)cc4CC3)n2C)cn1,J Med Chem,CHEMBL244945,0.15849,Yes,6.799998135
CHEMBL895464,Displacement of [3H]dofetilide from hERG expressed in CHO cells,COc1ccc(-c2nnc(SCCCN3CCc4ccc(-c5cc(C)on5)cc4CC3)n2C)cc1,J Med Chem,CHEMBL242600,0.03981,Yes,7.400007822
CHEMBL895464,Displacement of [3H]dofetilide from hERG expressed in CHO cells,COc1ccccc1-c1nnc(SCCCN2CCc3ccc(-c4cc(C)on4)cc3CC2)n1C,J Med Chem,CHEMBL390429,0.03981,Yes,7.400007822
CHEMBL895464,Displacement of [3H]dofetilide from hERG expressed in CHO cells,Cc1cc(-c2ccc3c(c2)CCN(CCCSc2nnc(C4CCC(C)CC4)n2C)CC3)no1,J Med Chem,CHEMBL243860,0.12589,Yes,6.900008766
CHEMBL895464,Displacement of [3H]dofetilide from hERG expressed in CHO cells,Cc1cc(-c2ccc3c(c2)CCN(CCCSc2nnc(C4CCCC4)n2C)CC3)no1,J Med Chem,CHEMBL243859,0.79433,Yes,6.099999035
CHEMBL895464,Displacement of [3H]dofetilide from hERG expressed in CHO cells,Cc1cc(-c2ccc3c(c2)CCN(CCCSc2nnc(C(C)(C)C)n2C)CC3)no1,J Med Chem,CHEMBL243474,0.39811,Yes,6.399996913
CHEMBL895464,Displacement of [3H]dofetilide from hERG expressed in CHO cells,Cc1cc(-c2ccc3c(c2)CCN(CCCSc2nnc(C(F)(F)F)n2C)CC3)no1,J Med Chem,CHEMBL243900,0.31623,Yes,6.499996932
CHEMBL895464,Displacement of [3H]dofetilide from hERG expressed in CHO cells,Cc1cc(-c2ccc3c(c2)CCN(CCCSc2nnc(C)n2C)CC3)no1,J Med Chem,CHEMBL243899,0.79433,Yes,6.099999035
CHEMBL895464,Displacement of [3H]dofetilide from hERG expressed in CHO cells,Cc1cc(-c2ccc3c(c2)CCN(CCCSc2nnc(-c4cccc(F)c4)n2C)CC3)no1,J Med Chem,CHEMBL244280,0.25119,Yes,6.599997654
CHEMBL895464,Displacement of [3H]dofetilide from hERG expressed in CHO cells,Cc1cc(-c2ccc3c(c2)CCN(CCCSc2nnc(-c4ccc(Cl)c(Cl)c4)n2C)CC3)no1,J Med Chem,CHEMBL397222,0.01,Yes,8
CHEMBL895464,Displacement of [3H]dofetilide from hERG expressed in CHO cells,Cc1cc(-c2ccc3c(c2)CCN(CCCSc2nnc(-c4ccc(Cl)cc4)n2C)CC3)no1,J Med Chem,CHEMBL244279,0.02512,Yes,7.599980365
CHEMBL895464,Displacement of [3H]dofetilide from hERG expressed in CHO cells,Cc1cc(-c2ccc3c(c2)CCN(CCCSc2nnc(-c4cccc(Cl)c4)n2C)CC3)no1,J Med Chem,CHEMBL244278,0.07943,Yes,7.100015437
CHEMBL895464,Displacement of [3H]dofetilide from hERG expressed in CHO cells,Cc1cc(-c2ccc3c(c2)CCN(CCCSc2nnc(-c4ccccc4Cl)n2C)CC3)no1,J Med Chem,CHEMBL244087,0.0631,Yes,7.199970641
CHEMBL895464,Displacement of [3H]dofetilide from hERG expressed in CHO cells,Cc1cc(-c2ccc3c(c2)CCN(CCCSc2nnc(-c4cccn4C)n2C)CC3)no1,J Med Chem,CHEMBL395743,0.25119,Yes,6.599997654
CHEMBL895464,Displacement of [3H]dofetilide from hERG expressed in CHO cells,Cc1cc(-c2ccc3c(c2)CCN(CCCSc2nnc(-c4cccs4)n2C)CC3)no1,J Med Chem,CHEMBL244086,0.12589,Yes,6.900008766
CHEMBL895464,Displacement of [3H]dofetilide from hERG expressed in CHO cells,Cc1cc(-c2ccc3c(c2)CCN(CCCSc2nnc(-c4ccncc4)n2C)CC3)no1,J Med Chem,CHEMBL244085,0.79433,Yes,6.099999035
CHEMBL895464,Displacement of [3H]dofetilide from hERG expressed in CHO cells,Cc1cc(-c2ccc3c(c2)CCN(CCCSc2nnc(-c4ccccn4)n2C)CC3)no1,J Med Chem,CHEMBL243898,0.25119,Yes,6.599997654
CHEMBL895464,Displacement of [3H]dofetilide from hERG expressed in CHO cells,Cc1ccc(-c2nnc(SCCCN3CCc4ccc(-c5cc(C)on5)cc4CC3)n2C)cc1,J Med Chem,CHEMBL395742,0.02512,Yes,7.599980365
CHEMBL895464,Displacement of [3H]dofetilide from hERG expressed in CHO cells,Cc1cc(-c2ccc3c(c2)CCN(CCCSc2nnc(-c4ccc(C(F)(F)F)cc4)n2C)CC3)no1,J Med Chem,CHEMBL243897,0.0631,Yes,7.199970641
CHEMBL895464,Displacement of [3H]dofetilide from hERG expressed in CHO cells,Cc1cc(-c2ccc3c(c2)CCN(CCCSc2nnc(-c4ccc(C#N)cc4)n2C)CC3)no1,J Med Chem,CHEMBL243896,0.01995,Yes,7.7000571
CHEMBL895464,Displacement of [3H]dofetilide from hERG expressed in CHO cells,Cc1cc(-c2ccc3c(c2)CCN(CCCSc2nnc(-c4ccc5nc(C)c(C)nc5c4)n2C)CC3)no1,J Med Chem,CHEMBL243708,0.31623,Yes,6.499996932
CHEMBL895464,Displacement of [3H]dofetilide from hERG expressed in CHO cells,Cc1ccc2c(-c3nnc(SCCCN4CCc5ccc(-c6cc(C)on6)cc5CC4)n3C)cccc2n1,J Med Chem,CHEMBL243707,0.50119,Yes,6.299997603
CHEMBL895464,Displacement of [3H]dofetilide from hERG expressed in CHO cells,Cc1cnc(-c2ccc3c(c2)CCN(CCCSc2nnc(-c4cccn4C)n2C)CC3)o1,J Med Chem,CHEMBL244277,0.50119,Yes,6.299997603
CHEMBL895464,Displacement of [3H]dofetilide from hERG expressed in CHO cells,Cc1cnc(-c2ccc3c(c2)CCN(CCCSc2nnc(-c4ccc5[nH]ccc5c4)n2C)CC3)o1,J Med Chem,CHEMBL244276,0.03981,Yes,7.400007822
CHEMBL895464,Displacement of [3H]dofetilide from hERG expressed in CHO cells,Cc1cnc(-c2ccc3c(c2)CCN(CCCSc2nnc(-c4cc5ccccc5[nH]4)n2C)CC3)o1,J Med Chem,CHEMBL397429,0.05012,Yes,7.299988938
CHEMBL895464,Displacement of [3H]dofetilide from hERG expressed in CHO cells,Cc1cnc(-c2ccc3c(c2)CCN(CCCSc2nnc(-c4cccs4)n2C)CC3)o1,J Med Chem,CHEMBL244275,0.31623,Yes,6.499996932
CHEMBL895464,Displacement of [3H]dofetilide from hERG expressed in CHO cells,Cc1ccc2c(-c3nnc(SCCCN4CCc5ccc(-c6ncc(C)o6)cc5CC4)n3C)cccc2n1,J Med Chem,CHEMBL244084,0.79433,Yes,6.099999035
CHEMBL895478,Binding affinity to hERG expressed in CHO cells by patch clamp assay,Cc1ccc2c(-c3nnc(SCCCN4CCc5ccc(-c6cc(C)on6)cc5CC4)n3C)cccc2n1,J Med Chem,CHEMBL243707,0.12589,Yes,6.900008766
CHEMBL890046,Inhibition of hERG,CCN(CC)C(C)CCCNc1nccc(NCc2ccc(Cl)cc2Cl)n1.N,Bioorg Med Chem Lett,CHEMBL233047,0.3,Yes,6.522878745
CHEMBL898851,Inhibition of human ERG,CN(C)C(=O)[C@@H](c1ccc(-c2ccc3ncnn3c2)cc1)[C@H](N)C(=O)N1CC[C@H](F)C1,Bioorg Med Chem Lett,CHEMBL237337,86,No,4.065501549
CHEMBL903096,Displacement of [3H]dofetilide from hERG expressed in CHOK1 cells,Cl.O=C(c1ccccc1)N1CCN(c2ccc(OCCCN3CCCCC3)cc2)C(=O)C1,J Med Chem,CHEMBL559206,63.09573,No,4.200000031
CHEMBL903096,Displacement of [3H]dofetilide from hERG expressed in CHOK1 cells,Cl.O=C(c1ccc(Cl)cc1)N1CCN(c2ccc(OC3CCN(C4CCC4)CC3)cc2)C(=O)C1,J Med Chem,CHEMBL540634,31.62278,No,4.499999953
CHEMBL903096,Displacement of [3H]dofetilide from hERG expressed in CHOK1 cells,C[C@H]1CCCN1CCCOc1ccc(N2CCN(C(=O)c3ccc(F)cc3F)CC2=O)cc1.O=CO,J Med Chem,CHEMBL239724,31.62278,No,4.499999953
CHEMBL903096,Displacement of [3H]dofetilide from hERG expressed in CHOK1 cells,C[C@@H]1CCCN1CCCOc1ccc(N2CCN(C(=O)c3cc(F)cc(F)c3)CC2=O)cc1.O=CO,J Med Chem,CHEMBL239081,0.50119,Yes,6.299997603
CHEMBL903096,Displacement of [3H]dofetilide from hERG expressed in CHOK1 cells,O=C(c1ccc(F)cc1F)N1CCN(c2ccc(OCCCN3CCCCCC3)cc2)C(=O)C1.O=CO,J Med Chem,CHEMBL238872,50.11872,No,4.300000029
CHEMBL903096,Displacement of [3H]dofetilide from hERG expressed in CHOK1 cells,O=C(c1cc(F)cc(F)c1)N1CCN(c2ccc(OCCCN3CCCCC3)cc2)C(=O)C1.O=CO,J Med Chem,CHEMBL240394,39.81072,No,4.399999968
CHEMBL903096,Displacement of [3H]dofetilide from hERG expressed in CHOK1 cells,O=C(c1ccc(F)cc1)N1CCN(c2ccc(OCCCN3CCCCC3)cc2)C(=O)C1.O=CO,J Med Chem,CHEMBL240185,50.11872,No,4.300000029
CHEMBL903096,Displacement of [3H]dofetilide from hERG expressed in CHOK1 cells,Cc1ccc(C(=O)N2CCN(c3ccc(OCCCN4CCCCC4)cc3)C(=O)C2)cc1.Cl,J Med Chem,CHEMBL536991,31.62278,No,4.499999953
CHEMBL886903,Displacement of [3H]dofetilide from hERG expressed in HEK293 cell membrane,O=C(NCCN1CCCCC1)c1ccc(CN2CCC(NC(=O)c3cc(=O)c4ccc(F)cc4o3)CC2)cc1,Bioorg Med Chem Lett,CHEMBL246050,66,No,4.180456064
CHEMBL886903,Displacement of [3H]dofetilide from hERG expressed in HEK293 cell membrane,CC(C)CO/N=C/COc1ccc(CN2CCC(NC(=O)c3cc(=O)c4ccc(F)cc4o3)CC2)cc1F,Bioorg Med Chem Lett,CHEMBL394639,0.45,Yes,6.346787486
CHEMBL886903,Displacement of [3H]dofetilide from hERG expressed in HEK293 cell membrane,O=C(NC1CCN(Cc2ccc(OCCCN(C3CC3)C3CC3)c(F)c2)CC1)c1cc(=O)c2ccc(F)cc2o1,Bioorg Med Chem Lett,CHEMBL247891,0.74,Yes,6.13076828
CHEMBL886903,Displacement of [3H]dofetilide from hERG expressed in HEK293 cell membrane,O=C(NC1CCN(Cc2ccc(OCCCN3CCOCC3)c(F)c2)CC1)c1cc(=O)c2ccc(F)cc2o1,Bioorg Med Chem Lett,CHEMBL247690,34,No,4.468521083
CHEMBL886903,Displacement of [3H]dofetilide from hERG expressed in HEK293 cell membrane,O=C(NC1CCN(Cc2ccc(OCCCN3CCCCC3)c(F)c2)CC1)c1cc(=O)c2ccc(F)cc2o1,Bioorg Med Chem Lett,CHEMBL248297,42,No,4.37675071
CHEMBL886903,Displacement of [3H]dofetilide from hERG expressed in HEK293 cell membrane,CN(C)CCCOc1ccc(CN2CCC(NC(=O)c3cc(=O)c4ccc(F)cc4o3)CC2)cc1F,Bioorg Med Chem Lett,CHEMBL248296,65,No,4.187086643
CHEMBL887127,Inhibition of cardiac hERG,C[C@@H](C1CCC(N(C)C(=O)C2CC2)CC1)[C@H](N)C(=O)N1CC[C@H](F)C1.Cl,Bioorg Med Chem Lett,CHEMBL392825,39,No,4.408935393
CHEMBL887127,Inhibition of cardiac hERG,C[C@@H](C1CCC(N(C)C(=O)c2cccc(F)c2)CC1)[C@H](N)C(=O)N1CC[C@H](F)C1.Cl,Bioorg Med Chem Lett,CHEMBL245379,78,No,4.107905397
CHEMBL887127,Inhibition of cardiac hERG,Cl.N[C@H](C(=O)N1CC[C@H](F)C1)C1CCC(NS(=O)(=O)c2ccc(F)cc2F)CC1,Bioorg Med Chem Lett,CHEMBL395213,49,No,4.30980392
CHEMBL941016,Inhibition of hERG expressed in HEK cells,CC(=O)C1=NN2c3cc(F)ccc3OC[C@H]2[C@@]1(CCCN)c1ccccc1,Bioorg Med Chem Lett,CHEMBL250127,0.94,Yes,6.026872146
CHEMBL943040,Inhibition of hERG by patch clamp assay,Cc1nnc(-c2ccc(CN3C[C@H](N)[C@H](C(=O)N4CCC[C@H]4C#N)C3)cc2)o1,Bioorg Med Chem Lett,CHEMBL399726,165,No,3.782516056
CHEMBL925077,Inhibition of hERG,CC(=O)c1cccc(NC(=O)N[C@@H]2CCCC[C@H]2CN2CCC[C@@H](Cc3ccc(F)cc3)C2)c1,Bioorg Med Chem Lett,CHEMBL250689,0.4,Yes,6.397940009
CHEMBL944718,Inhibition of hERG potassium channel expressed in CHO cells by isotope efflux assay,C[C@@H](NC(=O)c1ccc(-c2ccc(Cl)cc2)o1)C(=O)N1CCN(CCCOc2ccc(C(=O)C3CC3)cc2)CC1,J Med Chem,CHEMBL251241,0.8,Yes,6.096910013
CHEMBL944859,Displacement of [33S]MK499 from human ERG expressed in HEK cells,CC(C)[C@]1(C(=O)NCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)CC[C@@H](N2CCC(c3ccc(F)cc3)CC2)C1,Bioorg Med Chem Lett,CHEMBL428594,0.016,Yes,7.795880017
CHEMBL944859,Displacement of [33S]MK499 from human ERG expressed in HEK cells,CC(C)[C@]1(C(=O)NCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)CC[C@@H](N2CCC(c3cccc(C(=O)O)c3)CC2)C1,Bioorg Med Chem Lett,CHEMBL255511,0.6,Yes,6.22184875
CHEMBL944859,Displacement of [33S]MK499 from human ERG expressed in HEK cells,CC(C)[C@]1(C(=O)NCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)CC[C@@H](N2CCC(c3ccncn3)CC2)C1,Bioorg Med Chem Lett,CHEMBL256954,0.13,Yes,6.886056648
CHEMBL944859,Displacement of [33S]MK499 from human ERG expressed in HEK cells,CC(C)(O)[C@]1(C(=O)NCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)CC[C@@H](N2CCC(c3cc(Cl)ncn3)CC2)C1,Bioorg Med Chem Lett,CHEMBL401608,0.186,Yes,6.730487056
CHEMBL944859,Displacement of [33S]MK499 from human ERG expressed in HEK cells,CC(C)(O)[C@]1(C(=O)NCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)CC[C@@H](N2CCC(c3cncnc3)CC2)C1,Bioorg Med Chem Lett,CHEMBL429849,0.844,Yes,6.073657553
CHEMBL944859,Displacement of [33S]MK499 from human ERG expressed in HEK cells,CC(C)[C@]1(C(=O)NCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)CC[C@@H](N2CCC(c3cccc(O)c3)CC2)C1,Bioorg Med Chem Lett,CHEMBL255312,0.067,Yes,7.173925197
CHEMBL944859,Displacement of [33S]MK499 from human ERG expressed in HEK cells,COc1cccc(C2CCN([C@@H]3CC[C@@](C(=O)NCc4cc(C(F)(F)F)cc(C(F)(F)F)c4)(C(C)C)C3)CC2)c1,Bioorg Med Chem Lett,CHEMBL403033,0.217,Yes,6.663540266
CHEMBL944859,Displacement of [33S]MK499 from human ERG expressed in HEK cells,CC(C)[C@]1(C(=O)NCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)CC[C@@H](N2CCC(c3cccc(F)c3)CC2)C1,Bioorg Med Chem Lett,CHEMBL258246,0.045,Yes,7.346787486
CHEMBL944859,Displacement of [33S]MK499 from human ERG expressed in HEK cells,CC(C)(O)[C@]1(C(=O)NCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)CC[C@@H](N2CCC(c3ccc(F)cc3)CC2)C1,Bioorg Med Chem Lett,CHEMBL428602,0.054,Yes,7.26760624
CHEMBL944859,Displacement of [33S]MK499 from human ERG expressed in HEK cells,CC(C)[C@]1(C(=O)NCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)CC[C@@H](N2CCC(c3cccnc3)CC2)C1,Bioorg Med Chem Lett,CHEMBL255513,0.224,Yes,6.649751982
CHEMBL928561,Displacement of [3H]dofetilide from human ERG expressed in HEK293 cell membranes,Cc1cccnc1C(=O)N1CCC(C)(N2CCC(N(c3ccccc3)c3cccnc3)CC2)CC1,Bioorg Med Chem Lett,CHEMBL255431,0.41,Yes,6.387216143
CHEMBL928561,Displacement of [3H]dofetilide from human ERG expressed in HEK293 cell membranes,Cc1cccc(C)c1C(=O)N1CCC(C)(N2CCC(N(Cc3ccccc3)c3ccccc3)CC2)CC1,Bioorg Med Chem Lett,CHEMBL301454,0.67,Yes,6.173925197
CHEMBL928561,Displacement of [3H]dofetilide from human ERG expressed in HEK293 cell membranes,Cc1cccc(C)c1C(=O)N1CCC(C)(N2CCC(N(c3ccccc3)c3ccccc3)CC2)CC1,Bioorg Med Chem Lett,CHEMBL62152,0.15,Yes,6.823908741
CHEMBL928561,Displacement of [3H]dofetilide from human ERG expressed in HEK293 cell membranes,Cc1cc[n+]([O-])c(C)c1C(=O)N1CCC(C)(N2CCC(N(Cc3ccccc3)c3ccccc3)CC2)CC1,Bioorg Med Chem Lett,CHEMBL61536,0.55,Yes,6.259637311
CHEMBL928561,Displacement of [3H]dofetilide from human ERG expressed in HEK293 cell membranes,Cc1ccnc(C)c1C(=O)N1CCC(C)(N2CCC(N(c3ccccc3)c3ccccc3)CC2)CC1,Bioorg Med Chem Lett,CHEMBL58387,0.57,Yes,6.244125144
CHEMBL930660,Inhibition of human ERG,CNC(=O)[C@@H](C)Oc1cccc2ncnc(Nc3ccc(OCc4ccccn4)c(Cl)c3)c12,Bioorg Med Chem Lett,CHEMBL403594,32,No,4.494850022
CHEMBL931097,Inhibition of human ERG,Cc1cc(-c2nc3c4c(ccc3o2)CCN(CCCSc2nnc(-c3ocnc3C)n2C)CC4)n(C)n1,Bioorg Med Chem Lett,CHEMBL272297,0.79433,Yes,6.099999035
CHEMBL931097,Inhibition of human ERG,Cc1ccc2c(-c3nnc(SCCCN4CCc5ccc6oc(-c7cc(C)nn7C)nc6c5CC4)n3C)cccc2n1,Bioorg Med Chem Lett,CHEMBL402853,0.79433,Yes,6.099999035
CHEMBL931097,Inhibition of human ERG,Cc1nc(C)c(-c2nnc(SCCCN3CCc4ccc5oc(C(F)(F)F)nc5c4CC3)n2C)s1,Bioorg Med Chem Lett,CHEMBL270376,0.79433,Yes,6.099999035
CHEMBL931097,Inhibition of human ERG,Cn1c(SCCCN2CCc3ccc4oc(C(F)(F)F)nc4c3CC2)nnc1-c1ccccc1,Bioorg Med Chem Lett,CHEMBL270387,0.25119,Yes,6.599997654
CHEMBL931097,Inhibition of human ERG,Cc1ncoc1-c1nnc(SCCCN2CCc3ccc4oc(C(F)(F)C(F)(F)F)nc4c3CC2)n1C,Bioorg Med Chem Lett,CHEMBL402215,0.31623,Yes,6.499996932
CHEMBL931097,Inhibition of human ERG,Cc1ccc2c(-c3nnc(SCCCN4CCc5ccc6oc(C(F)(F)C(F)(F)F)nc6c5CC4)n3C)cccc2n1,Bioorg Med Chem Lett,CHEMBL271034,0.25119,Yes,6.599997654
CHEMBL931097,Inhibition of human ERG,Cc1ncoc1-c1nnc(SCCCN2CCc3nc4cc(C(F)(F)F)ccn4c3CC2)n1C,Bioorg Med Chem Lett,CHEMBL272588,0.79433,Yes,6.099999035
CHEMBL931097,Inhibition of human ERG,Cc1ccc2c(-c3nnc(SCCCN4CCc5nc6cc(C(F)(F)F)ccn6c5CC4)n3C)cccc2n1,Bioorg Med Chem Lett,CHEMBL411293,0.25119,Yes,6.599997654
CHEMBL931097,Inhibition of human ERG,Cc1ccn2c3c(nc2c1)CCN(CCCSc1nnc(-c2cccc4nc(C)ccc24)n1C)CC3,Bioorg Med Chem Lett,CHEMBL257717,0.25119,Yes,6.599997654
CHEMBL931097,Inhibition of human ERG,CCc1nc2ccc3c(c2s1)CCN(CCCSc1nnc(-c2cccc4nc(C)ccc24)n1C)CC3,Bioorg Med Chem Lett,CHEMBL256442,0.15849,Yes,6.799998135
CHEMBL948183,Displacement of [3H]Dofetilide from human ERG,Cc1ccc2c(-c3nnc(SCCCN4CCc5cc6c(cc5CC4)OCC(=O)N6)n3C)cccc2n1,Bioorg Med Chem Lett,CHEMBL271066,0.00631,Yes,8.199970641
CHEMBL948183,Displacement of [3H]Dofetilide from human ERG,Cc1ccc2c(-c3nnc(SCCCN4CCc5cc6c(cc5CC4)OCCN6)n3C)cccc2n1,Bioorg Med Chem Lett,CHEMBL408169,0.39811,Yes,6.399996913
CHEMBL948183,Displacement of [3H]Dofetilide from human ERG,Cc1ncoc1-c1nnc(SCCCN2CCc3cc4c(cc3CC2)OCC(=O)N4)n1C,Bioorg Med Chem Lett,CHEMBL257536,0.0631,Yes,7.199970641
CHEMBL948183,Displacement of [3H]Dofetilide from human ERG,Cc1noc2cc3c(cc12)CCN(CCCSc1nnc(-c2ccc(C(F)(F)F)cc2)n1C)CC3,Bioorg Med Chem Lett,CHEMBL401576,0.12589,Yes,6.900008766
CHEMBL948183,Displacement of [3H]Dofetilide from human ERG,Cc1ccc2c(-c3nnc(SCCCN4CCc5cc6onc(C)c6cc5CC4)n3C)cccc2n1,Bioorg Med Chem Lett,CHEMBL257946,0.79433,Yes,6.099999035
CHEMBL948183,Displacement of [3H]Dofetilide from human ERG,Cc1ccc2c(-c3nnc(SCCCN4CCc5cc6nc(-c7cc(C)nn7C)oc6cc5CC4)n3C)cccc2n1,Bioorg Med Chem Lett,CHEMBL270567,0.50119,Yes,6.299997603
CHEMBL948183,Displacement of [3H]Dofetilide from human ERG,Cc1ncoc1-c1nnc(SCCCN2CCc3cc4nc(C(F)(F)C(F)(F)F)oc4cc3CC2)n1C,Bioorg Med Chem Lett,CHEMBL271083,0.19953,Yes,6.699991797
CHEMBL948183,Displacement of [3H]Dofetilide from human ERG,Cc1ccc2c(-c3nnc(SCCCN4CCc5cc6nc(C(F)(F)C(F)(F)F)oc6cc5CC4)n3C)cccc2n1,Bioorg Med Chem Lett,CHEMBL270227,0.1,Yes,7
CHEMBL948183,Displacement of [3H]Dofetilide from human ERG,CCc1nc2cc3c(cc2o1)CCN(CCCSc1nnc(-c2ccc(C(F)(F)F)cc2)n1C)CC3,Bioorg Med Chem Lett,CHEMBL271096,0.25119,Yes,6.599997654
CHEMBL948183,Displacement of [3H]Dofetilide from human ERG,Cc1nc2cc3c(cc2o1)CCN(CCCSc1nnc(-c2cccnc2)n1C)CC3,Bioorg Med Chem Lett,CHEMBL256653,50.11872,No,4.300000029
CHEMBL948183,Displacement of [3H]Dofetilide from human ERG,Cc1ccc2c(-c3nnc(SCCCN4CCc5cc6nc(C(C)(C)C)oc6cc5CC4)n3C)cccc2n1,Bioorg Med Chem Lett,CHEMBL429132,0.79433,Yes,6.099999035
CHEMBL948183,Displacement of [3H]Dofetilide from human ERG,CCCc1nc2cc3c(cc2o1)CCN(CCCSc1nnc(-c2cccc4nc(C)ccc24)n1C)CC3,Bioorg Med Chem Lett,CHEMBL402826,0.63096,Yes,6.199998172
CHEMBL948183,Displacement of [3H]Dofetilide from human ERG,Cc1nc2cc3c(cc2o1)CCN(CCCSc1nnc(-c2ocnc2C)n1C)CC3,Bioorg Med Chem Lett,CHEMBL255827,31.62278,No,4.499999953
CHEMBL948183,Displacement of [3H]Dofetilide from human ERG,Cc1ccc2c(-c3nnc(SCCN4CCc5cc6nc(C(F)(F)F)oc6c(C)c5CC4)n3C)cccc2n1,Bioorg Med Chem Lett,CHEMBL257900,0.39811,Yes,6.399996913
CHEMBL948183,Displacement of [3H]Dofetilide from human ERG,Cc1ccc2c(-c3nnc(SCCN4CCc5cc6nc(C(F)(F)F)oc6c(Br)c5CC4)n3C)cccc2n1,Bioorg Med Chem Lett,CHEMBL408208,0.63096,Yes,6.199998172
CHEMBL948183,Displacement of [3H]Dofetilide from human ERG,Cc1ccc2c(-c3nnc(SCCN4CCc5cc6nc(C)oc6cc5CC4)n3C)cccc2n1,Bioorg Med Chem Lett,CHEMBL256650,50.11872,No,4.300000029
CHEMBL948183,Displacement of [3H]Dofetilide from human ERG,Cc1ccc2c(-c3nnc(SCCCCN4CCc5cc6nc(C(F)(F)F)oc6c(C)c5CC4)n3C)cccc2n1,Bioorg Med Chem Lett,CHEMBL271097,0.25119,Yes,6.599997654
CHEMBL948183,Displacement of [3H]Dofetilide from human ERG,Cc1ccc2c(-c3nnc(SCCCCN4CCc5cc6nc(C(F)(F)F)oc6c(Br)c5CC4)n3C)cccc2n1,Bioorg Med Chem Lett,CHEMBL257369,0.25119,Yes,6.599997654
CHEMBL948183,Displacement of [3H]Dofetilide from human ERG,Cc1nc2cc3c(cc2o1)CCN(CCCCSc1nnc(-c2ocnc2C)n1C)CC3,Bioorg Med Chem Lett,CHEMBL271073,50.11872,No,4.300000029
CHEMBL948183,Displacement of [3H]Dofetilide from human ERG,Cc1ccc2c(-c3nnc(SCCCN4CCc5cc6nc(C(C)(C)C)oc6c(C)c5CC4)n3C)cccc2n1,Bioorg Med Chem Lett,CHEMBL402087,0.25119,Yes,6.599997654
CHEMBL948183,Displacement of [3H]Dofetilide from human ERG,CCc1nc2cc3c(c(C)c2o1)CCN(CCCSc1nnc(-c2cccc4nc(C)ccc24)n1C)CC3,Bioorg Med Chem Lett,CHEMBL401752,0.50119,Yes,6.299997603
CHEMBL948183,Displacement of [3H]Dofetilide from human ERG,Cc1ccc2c(-c3nnc(SCCCN4CCc5cc6nc(C(C)(C)C)oc6c(Br)c5CC4)n3C)cccc2n1,Bioorg Med Chem Lett,CHEMBL255566,0.39811,Yes,6.399996913
CHEMBL948183,Displacement of [3H]Dofetilide from human ERG,CCc1nc2cc3c(cc2s1)CCN(CCCSc1nnc(-c2cccc4nc(C)ccc24)n1C)CC3,Bioorg Med Chem Lett,CHEMBL271631,0.25119,Yes,6.599997654
CHEMBL948183,Displacement of [3H]Dofetilide from human ERG,Cc1ccc2c(-c3nnc(SCCC(C)N4CCc5cc6c(cc5CC4)C(=O)N(C)C6)n3C)cccc2n1,Bioorg Med Chem Lett,CHEMBL272300,39.81072,No,4.399999968
CHEMBL948183,Displacement of [3H]Dofetilide from human ERG,Cc1ccc2c(-c3nnc(SCCCCN4CCc5cc6c(cc5CC4)C(=O)N(C)C6)n3C)cccc2n1,Bioorg Med Chem Lett,CHEMBL270853,31.62278,No,4.499999953
CHEMBL948146,Displacement of [3H]dofetilide from human recombinant ERG potassium channel expressed in HEK293 cells by patch clamp method,OCc1ccc(OC2CCN(CC3CCNCC3)CC2)cc1Cl,J Med Chem,CHEMBL272241,2951.20923,No,2.53
CHEMBL948146,Displacement of [3H]dofetilide from human recombinant ERG potassium channel expressed in HEK293 cells by patch clamp method,O=C(c1ccc(O)cc1OC[C@@H](O)CN1CCC2(CC1)Cc1cc(Cl)ccc1O2)N1C[C@H](O)CO1,J Med Chem,CHEMBL439304,0.02512,Yes,7.599980365
CHEMBL948146,Displacement of [3H]dofetilide from human recombinant ERG potassium channel expressed in HEK293 cells by patch clamp method,O=C(c1ccncc1)N1CCC2(CCN(Cc3cccc(Oc4ccccc4)c3)CC2)CC1,J Med Chem,CHEMBL271801,0.36308,Yes,6.439997673
CHEMBL948146,Displacement of [3H]dofetilide from human recombinant ERG potassium channel expressed in HEK293 cells by patch clamp method,COc1ccccc1Oc1cccc(CN2CCC3(CC2)CCN(C(=O)c2ccc(Cl)cc2)CC3)c1,J Med Chem,CHEMBL409648,0.1,Yes,7
CHEMBL948146,Displacement of [3H]dofetilide from human recombinant ERG potassium channel expressed in HEK293 cells by patch clamp method,O=C(c1ccc(Cl)cc1)N1CCC2(CCN(Cc3cccc(Oc4ccccc4)c3)CC2)CC1,J Med Chem,CHEMBL429436,0.08128,Yes,7.090016305
CHEMBL948146,Displacement of [3H]dofetilide from human recombinant ERG potassium channel expressed in HEK293 cells by patch clamp method,COc1ccccc1Oc1ccccc1CN1CCC2(CC1)CCN(C(=O)c1cc[n+]([O-])cc1)CC2,J Med Chem,CHEMBL270971,0.20893,Yes,6.679999196
CHEMBL948146,Displacement of [3H]dofetilide from human recombinant ERG potassium channel expressed in HEK293 cells by patch clamp method,COc1ccccc1Oc1ccccc1CN1CCC2(CC1)CCN(C(=O)c1ccncc1)CC2,J Med Chem,CHEMBL271128,0.0302,Yes,7.519993057
CHEMBL948146,Displacement of [3H]dofetilide from human recombinant ERG potassium channel expressed in HEK293 cells by patch clamp method,COc1ccccc1Oc1ccccc1CN1CCC2(CC1)CCN(C(=O)c1ccccn1)CC2,J Med Chem,CHEMBL271127,0.12023,Yes,6.919987153
CHEMBL948146,Displacement of [3H]dofetilide from human recombinant ERG potassium channel expressed in HEK293 cells by patch clamp method,O=C(c1ccncc1)N1CCC2(CCN(Cc3ccccc3Oc3ccccc3)CC2)CC1,J Med Chem,CHEMBL271768,0.02089,Yes,7.68006156
CHEMBL948146,Displacement of [3H]dofetilide from human recombinant ERG potassium channel expressed in HEK293 cells by patch clamp method,COc1ccccc1Oc1ccccc1CN1CCC2(CC1)CCN(C(=O)c1ccc(Cl)cc1)CC2,J Med Chem,CHEMBL409224,0.002512,Yes,8.599980365
CHEMBL948146,Displacement of [3H]dofetilide from human recombinant ERG potassium channel expressed in HEK293 cells by patch clamp method,O=C(c1ccc(Cl)cc1)N1CCC2(CCN(Cc3ccccc3Oc3ccccc3)CC2)CC1,J Med Chem,CHEMBL259243,0.006457,Yes,8.189969214
CHEMBL948146,Displacement of [3H]dofetilide from human recombinant ERG potassium channel expressed in HEK293 cells by patch clamp method,COc1ccccc1Oc1ccccc1CN1CCC2(CC1)CCN(C(=O)c1ccnc(N)c1)CC2,J Med Chem,CHEMBL429924,158489.3193,No,1
CHEMBL948146,Displacement of [3H]dofetilide from human recombinant ERG potassium channel expressed in HEK293 cells by patch clamp method,COc1ccccc1Oc1ccccc1CN1CCC2(CC1)CCN(C(=O)c1ccccn1)CC2,J Med Chem,CHEMBL271127,537031.7964,No,1
CHEMBL948146,Displacement of [3H]dofetilide from human recombinant ERG potassium channel expressed in HEK293 cells by patch clamp method,COc1ccccc1Oc1ccccc1CN1CCC2(CC1)CCN(C(=O)c1ccccc1-c1nnn[nH]1)CC2,J Med Chem,CHEMBL410862,512861.384,No,1
CHEMBL948146,Displacement of [3H]dofetilide from human recombinant ERG potassium channel expressed in HEK293 cells by patch clamp method,COc1ccccc1Oc1ccccc1CN1CCC2(CC1)CCN(C(=O)c1cc(Cl)c(Cl)cc1C(=O)O)CC2,J Med Chem,CHEMBL408483,954992.586,No,1
CHEMBL948146,Displacement of [3H]dofetilide from human recombinant ERG potassium channel expressed in HEK293 cells by patch clamp method,O=C(O)c1ccccc1N1CCC(CN2CCC(Oc3ccc(CO)c(Cl)c3)CC2)CC1,J Med Chem,CHEMBL409449,645654.229,No,1
CHEMBL948146,Displacement of [3H]dofetilide from human recombinant ERG potassium channel expressed in HEK293 cells by patch clamp method,O=C(O)c1cccc(N2CCC(CN3CCC(Oc4ccc(CO)c(Cl)c4)CC3)CC2)c1,J Med Chem,CHEMBL270116,512861.384,No,1
CHEMBL948146,Displacement of [3H]dofetilide from human recombinant ERG potassium channel expressed in HEK293 cells by patch clamp method,O=C(O)[C@H](Cc1ccccc1)N1CCC(CN2CCC(Oc3ccc(CO)c(Cl)c3)CC2)CC1,J Med Chem,CHEMBL272842,758577.575,No,1
CHEMBL948146,Displacement of [3H]dofetilide from human recombinant ERG potassium channel expressed in HEK293 cells by patch clamp method,N#CCCN1CCC(CN2CCC(Oc3ccc(CO)c(Cl)c3)CC2)CC1,J Med Chem,CHEMBL271766,251188.6432,No,1
CHEMBL948146,Displacement of [3H]dofetilide from human recombinant ERG potassium channel expressed in HEK293 cells by patch clamp method,COc1ccccc1Oc1ccccc1CN1CCC2(CC1)CCN(C(=O)c1ccccc1C(=O)O)CC2,J Med Chem,CHEMBL272441,43651.58322,No,1.36
CHEMBL948146,Displacement of [3H]dofetilide from human recombinant ERG potassium channel expressed in HEK293 cells by patch clamp method,COc1ccccc1Oc1ccccc1CN1CCC2(CC1)CCN(C(=O)c1cc(N)ccn1)CC2,J Med Chem,CHEMBL272846,6165.95002,No,2.21
CHEMBL948146,Displacement of [3H]dofetilide from human recombinant ERG potassium channel expressed in HEK293 cells by patch clamp method,Cc1ccc(C(=O)O)c(C(=O)N2CCC(CN3CCC(Oc4ccc(CO)c(Cl)c4)CC3)CC2)c1,J Med Chem,CHEMBL429763,100000,No,1
CHEMBL948146,Displacement of [3H]dofetilide from human recombinant ERG potassium channel expressed in HEK293 cells by patch clamp method,O=C(O)c1ccccc1C(=O)N1CCC(CN2CCC(Oc3ccc(CO)c(Cl)c3)CC2)CC1,J Med Chem,CHEMBL272242,97723.7221,No,1.01
CHEMBL948146,Displacement of [3H]dofetilide from human recombinant ERG potassium channel expressed in HEK293 cells by patch clamp method,CS(=O)(=O)c1ccc(CC(C(=O)O)N2CCC(CN3CCC(Oc4ccc(CO)c(Cl)c4)CC3)CC2)cc1,J Med Chem,CHEMBL429581,85113.80382,No,1.07
CHEMBL948146,Displacement of [3H]dofetilide from human recombinant ERG potassium channel expressed in HEK293 cells by patch clamp method,O=C(O)c1cccc(N2CCC(CN3CCC(Oc4ccc(CO)c(Cl)c4)CC3)CC2)n1,J Med Chem,CHEMBL271998,66069.3448,No,1.18
CHEMBL948146,Displacement of [3H]dofetilide from human recombinant ERG potassium channel expressed in HEK293 cells by patch clamp method,O=C(O)CN1CCC(CN2CCC(Oc3ccc(CO)c(Cl)c3)CC2)CC1,J Med Chem,CHEMBL406028,64565.4229,No,1.19
CHEMBL948146,Displacement of [3H]dofetilide from human recombinant ERG potassium channel expressed in HEK293 cells by patch clamp method,Cc1ncc(N2CCC(CN3CCC(Oc4ccc(CO)c(Cl)c4)CC3)CC2)cc1C(=O)O,J Med Chem,CHEMBL411448,37153.52291,No,1.43
CHEMBL948146,Displacement of [3H]dofetilide from human recombinant ERG potassium channel expressed in HEK293 cells by patch clamp method,O=C(O)[C@H](Cc1ccccn1)N1CCC(CN2CCC(Oc3ccc(CO)c(Cl)c3)CC2)CC1,J Med Chem,CHEMBL271405,33113.11215,No,1.48
CHEMBL948146,Displacement of [3H]dofetilide from human recombinant ERG potassium channel expressed in HEK293 cells by patch clamp method,CCC1C[C@H](N2CCC(CN3CCC(Oc4ccc(CO)c(Cl)c4)CC3)CC2)C(=O)O1,J Med Chem,CHEMBL271971,28183.82931,No,1.55
CHEMBL948146,Displacement of [3H]dofetilide from human recombinant ERG potassium channel expressed in HEK293 cells by patch clamp method,COC(=O)CCCN1CCC(CN2CCC(Oc3ccc(CO)c(Cl)c3)CC2)CC1,J Med Chem,CHEMBL402450,20417.37945,No,1.69
CHEMBL933193,Inhibition of human ERG by FLIPR assay,COc1ccc(N2C(=O)[C@@H](Cc3ccc(OCCc4nc(-c5ccccc5)oc4C)cc3)[C@H]2C(=O)O)cc1,Bioorg Med Chem Lett,CHEMBL411118,54,No,4.26760624
CHEMBL949251,Inhibition of human ERG potassium current expressed in HEK293 cells by patch-clamp technique,Cc1cc(C)n(-c2cc(NC(=O)CN3CCN(C)CC3)nc(-c3ccc(C)o3)n2)n1,J Med Chem,CHEMBL270467,0.95,Yes,6.022276395
CHEMBL949251,Inhibition of human ERG potassium current expressed in HEK293 cells by patch-clamp technique,Cc1cc(C)n(-c2cc(NC(=O)CCN(C)C)nc(-c3ccc(C)o3)n2)n1,J Med Chem,CHEMBL410234,0.65,Yes,6.187086643
CHEMBL949251,Inhibition of human ERG potassium current expressed in HEK293 cells by patch-clamp technique,CCN[C@H]1CCN(CC(=O)Nc2cc(-n3nc(C)cc3C)nc(-c3ccc(C)o3)n2)C1,J Med Chem,CHEMBL409229,0.42,Yes,6.37675071
CHEMBL949251,Inhibition of human ERG potassium current expressed in HEK293 cells by patch-clamp technique,Cc1cc(C)n(-c2cc(NC(=O)CN3CC[C@H](N(C)C)C3)nc(-c3ccc(C)o3)n2)n1,J Med Chem,CHEMBL271606,0.6,Yes,6.22184875
CHEMBL949251,Inhibition of human ERG potassium current expressed in HEK293 cells by patch-clamp technique,Cc1cc(C)n(-c2cc(NC(=O)CN3CCCN(C)CC3)nc(-c3ccc(C)o3)n2)n1,J Med Chem,CHEMBL409419,0.285,Yes,6.54515514
CHEMBL933468,Inhibition of human ERG,C[C@H](c1nc(-c2ccc(S(C)(=O)=O)cc2Cl)no1)[C@H](N)C(=O)N1CCCC1.O=C(O)C(F)(F)F,Bioorg Med Chem Lett,CHEMBL437206,37,No,4.431798276
CHEMBL933468,Inhibition of human ERG,CS(=O)(=O)c1ccc(-c2noc([C@@H](CCO)[C@H](N)C(F)=C3CCCC3)n2)c(Cl)c1.O=C(O)C(F)(F)F,Bioorg Med Chem Lett,CHEMBL445674,47,No,4.327902142
CHEMBL922329,Inhibition of human ERG channel,COC1OC2(CCN(Cc3ccccc3)CC2)c2cnn(-c3ccccc3)c21,Bioorg Med Chem,CHEMBL410832,0.00041,Yes,9.387216143
CHEMBL922329,Inhibition of human ERG channel,CCCCN1CCC2(CC1)OC(OC)c1c2cnn1-c1ccccc1,Bioorg Med Chem,CHEMBL259732,0.00065,Yes,9.187086643
CHEMBL988126,Inhibition of human ERG potassium channel,COc1ccc(Cl)cc1C(=O)NCCc1ccc(S(=O)(=O)NC(=O)NC2CCCCC2)cc1,Bioorg Med Chem,CHEMBL472,74,No,4.13076828
CHEMBL988126,Inhibition of human ERG potassium channel,COc1cc(NS(C)(=O)=O)ccc1Nc1c2ccccc2nc2ccccc12,Bioorg Med Chem,CHEMBL43,0.21,Yes,6.677780705
CHEMBL988126,Inhibition of human ERG potassium channel,Cc1cc2c(s1)Nc1ccccc1N=C2N1CCN(C)CC1,Bioorg Med Chem,CHEMBL715,0.181,Yes,6.742321425
CHEMBL988126,Inhibition of human ERG potassium channel,Cc1nccn1C[C@H]1CCc2c(c3ccccc3n2C)C1=O,Bioorg Med Chem,CHEMBL428411,0.81,Yes,6.091514981
CHEMBL988126,Inhibition of human ERG potassium channel,CN(C)c1cn(-c2ccc(F)cc2)c2ccc(Cl)cc12,Bioorg Med Chem,CHEMBL513608,0.011,Yes,7.958607315
CHEMBL988126,Inhibition of human ERG potassium channel,CCC[S+]([O-])CCCN(CC)CC(O)COc1ccc(C#N)cc1,Bioorg Med Chem,CHEMBL362103,0.005,Yes,8.301029996
CHEMBL973619,Inhibition of human ERG expressed in CHO cells by Patch clamp assay,O=C(COc1cccc(Cl)c1)NC1CCN(Cc2ccn(-c3ccc(C(F)(F)F)cc3)c2)CC1,Bioorg Med Chem Lett,CHEMBL472363,0.56,Yes,6.251811973
CHEMBL973619,Inhibition of human ERG expressed in CHO cells by Patch clamp assay,O=C(COc1cccc(Cl)c1)NC1CCN(Cc2ccn(-c3ccc(OC(F)(F)F)cc3)c2)CC1,Bioorg Med Chem Lett,CHEMBL512185,0.49,Yes,6.30980392
CHEMBL1016403,Inhibition of human ERG,CN1CCN(c2ncnc3c2nc(-c2ccc(Cl)cc2Cl)n3-c2ccc(Cl)cc2)CC1,J Med Chem,CHEMBL498411,0.35,Yes,6.455931956
CHEMBL1016403,Inhibition of human ERG,CN1CCN(c2ncnc3c2nc(-c2ccccc2Cl)n3-c2ccc(Cl)cc2)CC1,J Med Chem,CHEMBL496555,0.63,Yes,6.200659451
CHEMBL1006160,Inhibition of human ERG potassium channel by patch-clamp assay,CS(=O)(=O)c1ccc(OCC2CC2)c(C(=O)N2CCN(c3ccc(C#N)cc3F)CC2)c1,Bioorg Med Chem Lett,CHEMBL497999,0.6,Yes,6.22184875
CHEMBL1018632,Inhibition of human ERG by patch clamp technique,C[C@@H]1CN(CC2(C(N)=O)CCC2)CCN1S(=O)(=O)c1ccc(C(C)(O)C(F)(F)F)cc1,Bioorg Med Chem Lett,CHEMBL465956,65,No,4.187086643
CHEMBL1018632,Inhibition of human ERG by patch clamp technique,C[C@@H]1CN(CC2(c3ccncc3)CC2)CCN1S(=O)(=O)c1ccc(C(C)(O)C(F)(F)F)cc1,Bioorg Med Chem Lett,CHEMBL522964,0.44,Yes,6.356547324
CHEMBL1027667,Inhibition of human ERG channel,N#Cc1ccc2cc1Oc1ccc3c(c1)[C@@H](CC3)N1CC[C@@H](NCc3cncn3C2)C1=O,J Med Chem,CHEMBL526466,0.08,Yes,7.096910013
CHEMBL1027667,Inhibition of human ERG channel,CC(=O)Nc1cccc(N2CCN(CCCCNS(=O)(=O)c3ccc(C)cc3)CC2)c1,J Med Chem,CHEMBL210537,0.3,Yes,6.522878745
CHEMBL1027667,Inhibition of human ERG channel,N#Cc1ccc2cc1Oc1ccc3c(c1)[C@@H](CCO3)N1CC[C@@H](NCc3cncn3C2)C1=O,J Med Chem,CHEMBL516874,0.15,Yes,6.823908741
CHEMBL1027667,Inhibition of human ERG channel,CSc1ccc2c(c1)N(CCC1CCCCN1C)c1ccccc1S2,J Med Chem,CHEMBL479,0.0332,Yes,7.478861916
CHEMBL1027667,Inhibition of human ERG channel,O=C(CCCN1CCC(O)(c2ccc(Cl)cc2)CC1)c1ccc(F)cc1,J Med Chem,CHEMBL54,0.0268,Yes,7.571865206
CHEMBL1027667,Inhibition of human ERG channel,O=c1[nH]c2ccccc2n1C1CCN(CCCC(c2ccc(F)cc2)c2ccc(F)cc2)CC1,J Med Chem,CHEMBL1423,0.0546,Yes,7.262807357
CHEMBL1027667,Inhibition of human ERG channel,CN1CCN(C2=Nc3cc(Cl)ccc3Nc3ccccc32)CC1,J Med Chem,CHEMBL42,0.32,Yes,6.494850022
CHEMBL1027667,Inhibition of human ERG channel,Cc1nc2n(c(=O)c1CCN1CCC(c3noc4cc(F)ccc34)CC1)CCCC2,J Med Chem,CHEMBL85,0.148,Yes,6.829738285
CHEMBL1027667,Inhibition of human ERG channel,O=C1NCCN1CCN1CCC(c2cn(-c3ccc(F)cc3)c3ccc(Cl)cc23)CC1,J Med Chem,CHEMBL12713,0.0147,Yes,7.832682665
CHEMBL1027667,Inhibition of human ERG channel,O=C1Cc2cc(CCN3CCN(c4nsc5ccccc45)CC3)c(Cl)cc2N1,J Med Chem,CHEMBL708,0.125,Yes,6.903089987
CHEMBL1027667,Inhibition of human ERG channel,CN1CCCCC1CCN1c2ccccc2Sc2ccc([S+](C)[O-])cc21,J Med Chem,CHEMBL1088,0.32,Yes,6.494850022
CHEMBL1027667,Inhibition of human ERG channel,C[N+]1([O-])CCN(C2=Nc3cc(Cl)ccc3Nc3ccccc32)CC1,J Med Chem,CHEMBL1688,133.3,No,3.875169851
CHEMBL1027667,Inhibition of human ERG channel,CN1CCC[C@H]1c1cccnc1,J Med Chem,CHEMBL3,244.3,No,3.612076533
CHEMBL1027667,Inhibition of human ERG channel,CC(C)(C)c1ccc(C(O)CCCN2CCC(C(O)(c3ccccc3)c3ccccc3)CC2)cc1,J Med Chem,CHEMBL17157,0.213,Yes,6.671620397
CHEMBL1027667,Inhibition of human ERG channel,COc1cc(N)c(Cl)cc1C(=O)NC1CCN(CCCOc2ccc(F)cc2)CC1OC,J Med Chem,CHEMBL1729,0.0067,Yes,8.173925197
CHEMBL1027667,Inhibition of human ERG channel,Cc1cccc(CCN2CCC(C(=O)c3ccc(NS(C)(=O)=O)cc3)CC2)n1.Cl.Cl,J Med Chem,CHEMBL536480,0.0181,Yes,7.742321425
CHEMBL1027667,Inhibition of human ERG channel,Cc1cc2c(s1)Nc1ccccc1N=C2N1CCN(C)CC1,J Med Chem,CHEMBL715,0.2313,Yes,6.635824367
CHEMBL1027667,Inhibition of human ERG channel,N#Cc1ccc2cc1Oc1cc(Cl)cc(c1)CN1CC[C@@H](NCc3cncn3C2)C1=O,J Med Chem,CHEMBL524352,0.22,Yes,6.657577319
CHEMBL1027667,Inhibition of human ERG channel,N#Cc1ccc2cc1Oc1cccc(c1)C(c1ccccc1)N1CC[C@@H](NCc3cncn3C2)C1=O,J Med Chem,CHEMBL501480,0.32,Yes,6.494850022
CHEMBL1027667,Inhibition of human ERG channel,N#Cc1ccc2cc1Oc1cccc(c1)C(c1cccc(Cl)c1)N1CC[C@@H](NCc3cncn3C2)C1=O,J Med Chem,CHEMBL525413,0.082,Yes,7.086186148
CHEMBL1027667,Inhibition of human ERG channel,N#Cc1ccc2cc1Oc1cccc(c1)C(c1cccc(Cl)c1)N1CC[C@@H](NCc3cncn3C2)C1=O,J Med Chem,CHEMBL525413,0.53,Yes,6.27572413
CHEMBL1027667,Inhibition of human ERG channel,N#Cc1ccc2cc1Oc1ccc3cccc(c3c1)N1CC[C@@H](NCCc3cncn3C2)C1=O,J Med Chem,CHEMBL498260,0.21,Yes,6.677780705
CHEMBL1027667,Inhibition of human ERG channel,CN1CCc2cncn2Cc2ccc(C#N)c(c2)Oc2ccc3cccc(c3c2)N2CC[C@@H]1C2=O,J Med Chem,CHEMBL498100,0.18,Yes,6.744727495
CHEMBL1027667,Inhibition of human ERG channel,N#Cc1ccc2cc1Oc1ccc3c(c1)[C@@H](CC3)N1CC[C@@H](NCc3cncn3C2)C1=O,J Med Chem,CHEMBL526466,0.08,Yes,7.096910013
CHEMBL1027667,Inhibition of human ERG channel,N#Cc1ccc2cc1Oc1ccc3c(c1)[C@@H](CCO3)N1CC[C@@H](NCc3cncn3C2)C1=O,J Med Chem,CHEMBL516874,0.15,Yes,6.823908741
CHEMBL1027667,Inhibition of human ERG channel,N#Cc1ccc(Cn2cncc2CN[C@H]2CCN(Cc3cccc(Cl)c3)C2=O)cc1,J Med Chem,CHEMBL312137,0.44,Yes,6.356547324
CHEMBL1027667,Inhibition of human ERG channel,N#Cc1ccc(Cn2cncc2CN[C@H]2CCN(C(=O)c3cccnc3N)C2=O)cc1,J Med Chem,CHEMBL484816,50,No,4.301029996
CHEMBL1027667,Inhibition of human ERG channel,N#Cc1ccc(Cn2cncc2CN[C@H]2CCN(C(=O)c3cccnc3O)C2=O)cc1,J Med Chem,CHEMBL485161,50,No,4.301029996
CHEMBL1027667,Inhibition of human ERG channel,CCCCN(Cc1cncn1Cc1ccc(C#N)cc1)[C@H]1CCN(Cc2ccccc2)C1=O,J Med Chem,CHEMBL100415,0.19,Yes,6.721246399
CHEMBL1027667,Inhibition of human ERG channel,N#Cc1ccc(Cn2cncc2CN(Cc2cccnc2)[C@H]2CCN(Cc3ccccc3)C2=O)cc1,J Med Chem,CHEMBL327946,0.87,Yes,6.060480747
CHEMBL1027667,Inhibition of human ERG channel,N#Cc1ccc(Cn2cncc2CN(CCCc2ccccc2)[C@H]2CCN(Cc3ccccc3)C2=O)cc1,J Med Chem,CHEMBL329067,0.024,Yes,7.619788758
CHEMBL1027667,Inhibition of human ERG channel,N#Cc1ccc(Cn2cncc2CN(CCCN)[C@H]2CCN(Cc3ccccc3)C2=O)cc1,J Med Chem,CHEMBL322007,0.48,Yes,6.318758763
CHEMBL1027667,Inhibition of human ERG channel,N#Cc1ccc(Cn2cncc2CN(CCN2CCOCC2)[C@H]2CCN(Cc3ccccc3)C2=O)cc1,J Med Chem,CHEMBL526277,0.19,Yes,6.721246399
CHEMBL1027667,Inhibition of human ERG channel,CSc1ccc2c(c1)N(CCC1CCCCN1C)c1ccccc1S2,J Med Chem,CHEMBL479,0.0332,Yes,7.478861916
CHEMBL1027667,Inhibition of human ERG channel,O=C(CCCN1CCC(O)(c2ccc(Cl)cc2)CC1)c1ccc(F)cc1,J Med Chem,CHEMBL54,0.0268,Yes,7.571865206
CHEMBL1027667,Inhibition of human ERG channel,O=c1[nH]c2ccccc2n1C1CCN(CCCC(c2ccc(F)cc2)c2ccc(F)cc2)CC1,J Med Chem,CHEMBL1423,0.0546,Yes,7.262807357
CHEMBL1027667,Inhibition of human ERG channel,CN1CCN(C2=Nc3cc(Cl)ccc3Nc3ccccc32)CC1,J Med Chem,CHEMBL42,0.32,Yes,6.494850022
CHEMBL1027667,Inhibition of human ERG channel,Cc1nc2n(c(=O)c1CCN1CCC(c3noc4cc(F)ccc34)CC1)CCCC2,J Med Chem,CHEMBL85,0.148,Yes,6.829738285
CHEMBL1027667,Inhibition of human ERG channel,O=C1NCCN1CCN1CCC(c2cn(-c3ccc(F)cc3)c3ccc(Cl)cc23)CC1,J Med Chem,CHEMBL12713,0.0147,Yes,7.832682665
CHEMBL1027667,Inhibition of human ERG channel,O=C1Cc2cc(CCN3CCN(c4nsc5ccccc45)CC3)c(Cl)cc2N1,J Med Chem,CHEMBL708,0.125,Yes,6.903089987
CHEMBL1027667,Inhibition of human ERG channel,CN1CCCCC1CCN1c2ccccc2Sc2ccc([S+](C)[O-])cc21,J Med Chem,CHEMBL1088,0.32,Yes,6.494850022
CHEMBL1027667,Inhibition of human ERG channel,C[N+]1([O-])CCN(C2=Nc3cc(Cl)ccc3Nc3ccccc32)CC1,J Med Chem,CHEMBL1688,133.29995,No,3.875170013
CHEMBL1027667,Inhibition of human ERG channel,CN1CCC[C@H]1c1cccnc1,J Med Chem,CHEMBL3,244.29974,No,3.612076995
CHEMBL1027667,Inhibition of human ERG channel,CC(C)(C)c1ccc(C(O)CCCN2CCC(C(O)(c3ccccc3)c3ccccc3)CC2)cc1,J Med Chem,CHEMBL17157,0.213,Yes,6.671620397
CHEMBL1027667,Inhibition of human ERG channel,COc1cc(N)c(Cl)cc1C(=O)NC1CCN(CCCOc2ccc(F)cc2)CC1OC,J Med Chem,CHEMBL1729,0.0067,Yes,8.173925197
CHEMBL1027667,Inhibition of human ERG channel,Cc1cccc(CCN2CCC(C(=O)c3ccc(NS(C)(=O)=O)cc3)CC2)n1.Cl.Cl,J Med Chem,CHEMBL536480,0.0181,Yes,7.742321425
CHEMBL1027667,Inhibition of human ERG channel,Cc1cc2c(s1)Nc1ccccc1N=C2N1CCN(C)CC1,J Med Chem,CHEMBL715,0.2313,Yes,6.635824367
CHEMBL1027667,Inhibition of human ERG channel,CC(C)(C)OC(=O)NCCCN(Cc1cncn1Cc1ccc(C#N)cc1)[C@H]1CCN(Cc2ccccc2)C1=O,J Med Chem,CHEMBL98553,0.11,Yes,6.958607315
CHEMBL954102,Inhibition of human ERG expressed in CHO cells by whole cell patch clamp technique,COc1cc(Cc2cnc(N)nc2N)cc(OC)c1OC,Bioorg Med Chem,CHEMBL22,239.88329,No,3.620000003
CHEMBL954102,Inhibition of human ERG expressed in CHO cells by whole cell patch clamp technique,COc1ccc(C2CCN(CCC3CCOc4ccccc43)CC2)cc1OC,Bioorg Med Chem,CHEMBL94664,0.19953,Yes,6.699991797
CHEMBL954102,Inhibition of human ERG expressed in CHO cells by whole cell patch clamp technique,Cc1cc2c(s1)Nc1ccccc1N=C2N1CCN(C)CC1,Bioorg Med Chem,CHEMBL715,0.18197,Yes,6.740000205
CHEMBL954102,Inhibition of human ERG expressed in CHO cells by whole cell patch clamp technique,Fc1ccc(Cn2c(NC3CCNCC3)nc3ccccc32)cc1,Bioorg Med Chem,CHEMBL61301,0.02818,Yes,7.550059011
CHEMBL954102,Inhibition of human ERG expressed in CHO cells by whole cell patch clamp technique,O=C(CCCN1CC=C(n2c(=O)[nH]c3ccccc32)CC1)c1ccc(F)cc1,Bioorg Med Chem,CHEMBL1108,0.03236,Yes,7.489991487
CHEMBL954102,Inhibition of human ERG expressed in CHO cells by whole cell patch clamp technique,Oc1ccc(CCN2CCC(Nc3nc4ccccc4n3Cc3ccc(F)cc3)CC2)cc1,Bioorg Med Chem,CHEMBL60796,0.001,Yes,9
CHEMBL954102,Inhibition of human ERG expressed in CHO cells by whole cell patch clamp technique,COc1ccc(CCN(C)CCCC(C#N)(c2ccc(OC)c(OC)c2)C(C)C)cc1OC,Bioorg Med Chem,CHEMBL6966,0.14125,Yes,6.850011544
CHEMBL954102,Inhibition of human ERG expressed in CHO cells by whole cell patch clamp technique,CSc1ccc2c(c1)N(CCC1CCCCN1C)c1ccccc1S2,Bioorg Med Chem,CHEMBL479,0.36308,Yes,6.439997673
CHEMBL954102,Inhibition of human ERG expressed in CHO cells by whole cell patch clamp technique,COc1ccc(C2CCN(CC[C@H]3CCOc4ccccc43)CC2)cc1OC,Bioorg Med Chem,CHEMBL96153,0.25119,Yes,6.599997654
CHEMBL954102,Inhibition of human ERG expressed in CHO cells by whole cell patch clamp technique,CC(C)(C)c1ccc(C(O)CCCN2CCC(C(O)(c3ccccc3)c3ccccc3)CC2)cc1,Bioorg Med Chem,CHEMBL17157,0.19953,Yes,6.699991797
CHEMBL954102,Inhibition of human ERG expressed in CHO cells by whole cell patch clamp technique,O=C1NCCN1CCN1CCC(c2cn(-c3ccc(F)cc3)c3ccc(Cl)cc23)CC1,Bioorg Med Chem,CHEMBL12713,0.01,Yes,8
CHEMBL954102,Inhibition of human ERG expressed in CHO cells by whole cell patch clamp technique,Cc1nc2n(c(=O)c1CCN1CCC(c3noc4cc(F)ccc34)CC1)CCCC2,Bioorg Med Chem,CHEMBL85,0.15136,Yes,6.819988881
CHEMBL954102,Inhibition of human ERG expressed in CHO cells by whole cell patch clamp technique,C=C[C@H]1CN2CC[C@H]1C[C@@H]2[C@@H](O)c1ccnc2ccc(OC)cc12,Bioorg Med Chem,CHEMBL1294,0.32359,Yes,6.490004908
CHEMBL954102,Inhibition of human ERG expressed in CHO cells by whole cell patch clamp technique,O=c1[nH]c2ccccc2n1C1CCN(CCCC(c2ccc(F)cc2)c2ccc(F)cc2)CC1,Bioorg Med Chem,CHEMBL1423,0.05012,Yes,7.299988938
CHEMBL954102,Inhibition of human ERG expressed in CHO cells by whole cell patch clamp technique,Cc1nccn1CC1CCc2c(c3ccccc3n2C)C1=O,Bioorg Med Chem,CHEMBL46,0.81283,Yes,6.090000276
CHEMBL954102,Inhibition of human ERG expressed in CHO cells by whole cell patch clamp technique,CC1COc2c(N3CCN(C)CC3)c(F)cc3c(=O)c(C(=O)O)cn1c23,Bioorg Med Chem,CHEMBL4,1412.53754,No,2.850000001
CHEMBL954102,Inhibition of human ERG expressed in CHO cells by whole cell patch clamp technique,COC(=O)C1=C(C)NC(C)=C(C(=O)OC)C1c1ccccc1[N+](=O)[O-],Bioorg Med Chem,CHEMBL193,50.11872,No,4.300000029
CHEMBL954102,Inhibition of human ERG expressed in CHO cells by whole cell patch clamp technique,CN1CCC[C@H]1c1cccnc1,Bioorg Med Chem,CHEMBL3,245.47089,No,3.610000003
CHEMBL954102,Inhibition of human ERG expressed in CHO cells by whole cell patch clamp technique,COc1c(N2C[C@@H]3CCCN[C@@H]3C2)c(F)cc2c(=O)c(C(=O)O)cn(C3CC3)c12,Bioorg Med Chem,CHEMBL32,128.82496,No,3.889999984
CHEMBL954102,Inhibition of human ERG expressed in CHO cells by whole cell patch clamp technique,CN(c1nccc(=O)[nH]1)C1CCN(c2nc3ccccc3n2Cc2ccc(F)cc2)CC1,Bioorg Med Chem,CHEMBL94454,0.43652,Yes,6.359995853
CHEMBL954102,Inhibition of human ERG expressed in CHO cells by whole cell patch clamp technique,CN1CCCCC1CCN1c2ccccc2Sc2ccc([S+](C)[O-])cc21,Bioorg Med Chem,CHEMBL1088,0.32359,Yes,6.490004908
CHEMBL954102,Inhibition of human ERG expressed in CHO cells by whole cell patch clamp technique,CCOC(=O)N1CCC(=C2c3ccc(Cl)cc3CCc3cccnc32)CC1,Bioorg Med Chem,CHEMBL998,0.16982,Yes,6.770011163
CHEMBL954102,Inhibition of human ERG expressed in CHO cells by whole cell patch clamp technique,C[C@H]1COc2c(N3CCN(C)CC3)c(F)cc3c(=O)c(C(=O)O)cn1c23,Bioorg Med Chem,CHEMBL33,912.01084,No,3.04
CHEMBL954102,Inhibition of human ERG expressed in CHO cells by whole cell patch clamp technique,CCCCCCCN(CC)CCCC(O)c1ccc(NS(C)(=O)=O)cc1,Bioorg Med Chem,CHEMBL533,0.01,Yes,8
CHEMBL954102,Inhibition of human ERG expressed in CHO cells by whole cell patch clamp technique,O=C(CCCN1CCC(O)(c2ccc(Cl)cc2)CC1)c1ccc(F)cc1,Bioorg Med Chem,CHEMBL54,0.0302,Yes,7.519993057
CHEMBL954102,Inhibition of human ERG expressed in CHO cells by whole cell patch clamp technique,CCCCN(CCCC)CCC(O)c1cc2c(Cl)cc(Cl)cc2c2cc(C(F)(F)F)ccc12,Bioorg Med Chem,CHEMBL1107,0.19953,Yes,6.699991797
CHEMBL954102,Inhibition of human ERG expressed in CHO cells by whole cell patch clamp technique,Cc1c(F)c(N2CCNC(C)C2)cc2c1c(=O)c(C(=O)O)cn2C1CC1,Bioorg Med Chem,CHEMBL583,50.11872,No,4.300000029
CHEMBL954102,Inhibition of human ERG expressed in CHO cells by whole cell patch clamp technique,COc1c(N2CCNC(C)C2)c(F)cc2c(=O)c(C(=O)O)cn(C3CC3)c12,Bioorg Med Chem,CHEMBL31,128.82496,No,3.889999984
CHEMBL954102,Inhibition of human ERG expressed in CHO cells by whole cell patch clamp technique,NC1=NCC2c3ccccc3Cc3ccccc3N12,Bioorg Med Chem,CHEMBL1106,100,No,4
CHEMBL954102,Inhibition of human ERG expressed in CHO cells by whole cell patch clamp technique,Cc1cccc(CCN2CCC(C(=O)c3ccc(NS(C)(=O)=O)cc3)CC2)n1,Bioorg Med Chem,CHEMBL327980,0.01995,Yes,7.7000571
CHEMBL954102,Inhibition of human ERG expressed in CHO cells by whole cell patch clamp technique,CN(CCOc1ccc(NS(C)(=O)=O)cc1)CCc1ccc(NS(C)(=O)=O)cc1,Bioorg Med Chem,CHEMBL473,0.01,Yes,8
CHEMBL954102,Inhibition of human ERG expressed in CHO cells by whole cell patch clamp technique,CC(C)N(CCC(C(N)=O)(c1ccccc1)c1ccccn1)C(C)C,Bioorg Med Chem,CHEMBL517,91.20108,No,4.040000019
CHEMBL954102,Inhibition of human ERG expressed in CHO cells by whole cell patch clamp technique,O=C1Cc2cc(CCN3CCN(c4nsc5ccccc45)CC3)c(Cl)cc2N1,Bioorg Med Chem,CHEMBL708,0.12023,Yes,6.919987153
CHEMBL954102,Inhibition of human ERG expressed in CHO cells by whole cell patch clamp technique,CN1CCN(C2=Nc3cc(Cl)ccc3Nc3ccccc32)CC1,Bioorg Med Chem,CHEMBL42,0.32359,Yes,6.490004908
CHEMBL954102,Inhibition of human ERG expressed in CHO cells by whole cell patch clamp technique,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(OC)C[C@@H](C)C(=O)[C@H](C)[C@@H](O)[C@]1(C)O,Bioorg Med Chem,CHEMBL1741,58.88437,No,4.229999967
CHEMBL954102,Inhibition of human ERG expressed in CHO cells by whole cell patch clamp technique,COc1cc(N)c(Cl)cc1C(=O)NC1CCN(CCCOc2ccc(F)cc2)CC1OC,Bioorg Med Chem,CHEMBL1729,0.03981,Yes,7.400007822
CHEMBL954102,Inhibition of human ERG expressed in CHO cells by whole cell patch clamp technique,O=C(O)c1cn(C2CC2)c2cc(N3CCNCC3)c(F)cc2c1=O,Bioorg Med Chem,CHEMBL8,954.99259,No,3.019999998
CHEMBL954102,Inhibition of human ERG expressed in CHO cells by whole cell patch clamp technique,O=C(O)COCCN1CCN(C(c2ccccc2)c2ccc(Cl)cc2)CC1,Bioorg Med Chem,CHEMBL1000,30.19952,No,4.51999996
CHEMBL954102,Inhibition of human ERG expressed in CHO cells by whole cell patch clamp technique,CC(C)COCC(CN(Cc1ccccc1)c1ccccc1)N1CCCC1,Bioorg Med Chem,CHEMBL1008,0.54954,Yes,6.260000691
CHEMBL954102,Inhibition of human ERG expressed in CHO cells by whole cell patch clamp technique,COc1ccc(CCN2CCC(Nc3nc4ccccc4n3Cc3ccc(F)cc3)CC2)cc1,Bioorg Med Chem,CHEMBL296419,0.01,Yes,8
CHEMBL980868,Blockade of human ERG channel by whole cell patch clamp assay,CS(=O)(=O)N1CCN(Cc2cc3nc(-c4cccc5[nH]ncc45)nc(N4CCOCC4)c3s2)CC1,J Med Chem,CHEMBL521851,64,No,4.193820026
CHEMBL989030,Inhibition of human ERG channel in HEK293 cells by voltage-clamp method,C1=C(c2ccccc2)c2ccccc2OC12CCNCC2,J Med Chem,CHEMBL492447,0.68,Yes,6.167491087
CHEMBL989030,Inhibition of human ERG channel in HEK293 cells by voltage-clamp method,CCN(CC)C(=O)c1ccc(C2=CC3(CCNCC3)Oc3cccc(O)c32)cc1,J Med Chem,CHEMBL494480,78,No,4.107905397
CHEMBL989030,Inhibition of human ERG channel in HEK293 cells by voltage-clamp method,CCN(CC)C(=O)c1ccc(C2=CC3(CCNCC3)Oc3cc(O)ccc32)cc1,J Med Chem,CHEMBL495094,60,No,4.22184875
CHEMBL989030,Inhibition of human ERG channel in HEK293 cells by voltage-clamp method,CCN(CC)C(=O)c1ccc(C2=CC3(CCN(C)CC3)Oc3ccccc32)cc1,J Med Chem,CHEMBL494275,0.766,Yes,6.11577123
CHEMBL989030,Inhibition of human ERG channel in HEK293 cells by voltage-clamp method,CCN(CC)C(=O)c1ccc(C2=CC3(CCN(C(C)=O)CC3)Oc3ccccc32)cc1,J Med Chem,CHEMBL494274,47.44,No,4.32385532
CHEMBL989030,Inhibition of human ERG channel in HEK293 cells by voltage-clamp method,CCN(CC)C(=O)c1cccc(C2=CC3(CCNCC3)Oc3ccccc32)c1,J Med Chem,CHEMBL523204,0.303,Yes,6.518557371
CHEMBL989030,Inhibition of human ERG channel in HEK293 cells by voltage-clamp method,COC(=O)c1ccc(C2=CC3(CCNCC3)Oc3ccccc32)cc1,J Med Chem,CHEMBL494265,0.663,Yes,6.178486472
CHEMBL989030,Inhibition of human ERG channel in HEK293 cells by voltage-clamp method,Oc1ccc(C2=CC3(CCNCC3)Oc3ccccc32)cc1,J Med Chem,CHEMBL495074,0.643,Yes,6.191789027
CHEMBL989030,Inhibition of human ERG channel in HEK293 cells by voltage-clamp method,COc1ccc(C2=CC3(CCNCC3)Oc3ccccc32)cc1,J Med Chem,CHEMBL495073,0.585,Yes,6.232844134
CHEMBL989030,Inhibition of human ERG channel in HEK293 cells by voltage-clamp method,FC(F)(F)c1ccc(C2=CC3(CCNCC3)Oc3ccccc32)cc1,J Med Chem,CHEMBL492449,0.379,Yes,6.42136079
CHEMBL989030,Inhibition of human ERG channel in HEK293 cells by voltage-clamp method,Cc1ccc(C2=CC3(CCNCC3)Oc3ccccc32)cc1,J Med Chem,CHEMBL492448,0.462,Yes,6.335358024
CHEMBL1027247,Displacement of [3H]astemizole from human ERG expressed in HEK293 cells,CS(=O)(=O)Nc1ccc(OC[C@@H](O)CNCCc2ccc(Cl)c(Cl)c2)cc1,J Med Chem,CHEMBL492438,0.73,Yes,6.13667714
CHEMBL1027247,Displacement of [3H]astemizole from human ERG expressed in HEK293 cells,CS(=O)(=O)Nc1ccc(OC[C@@H](O)CN(CCc2ccc(Cl)c(Cl)c2)Cc2cccc(O)c2)cc1,J Med Chem,CHEMBL493712,0.78,Yes,6.107905397
CHEMBL1027247,Displacement of [3H]astemizole from human ERG expressed in HEK293 cells,CS(=O)(=O)Nc1ccc(OC[C@@H](O)CN(CCc2ccc(Cl)c(Cl)c2)Cc2ccccc2O)cc1,J Med Chem,CHEMBL495328,0.83,Yes,6.080921908
CHEMBL1027247,Displacement of [3H]astemizole from human ERG expressed in HEK293 cells,CS(=O)(=O)Nc1ccc(OC[C@@H](O)CN(CCc2ccc(Cl)c(Cl)c2)Cc2ccccc2)cc1,J Med Chem,CHEMBL493087,0.43,Yes,6.366531544
CHEMBL1027247,Displacement of [3H]astemizole from human ERG expressed in HEK293 cells,CC(C)CN(CCc1ccc(Cl)c(Cl)c1)C[C@H](O)COc1ccc(NS(C)(=O)=O)cc1,J Med Chem,CHEMBL494105,0.73,Yes,6.13667714
CHEMBL1027247,Displacement of [3H]astemizole from human ERG expressed in HEK293 cells,CCCCN(CCc1ccc(Cl)c(Cl)c1)C[C@H](O)COc1ccc(NS(C)(=O)=O)cc1,J Med Chem,CHEMBL494504,0.07,Yes,7.15490196
CHEMBL1027247,Displacement of [3H]astemizole from human ERG expressed in HEK293 cells,CCCN(CCc1ccc(Cl)c(Cl)c1)C[C@H](O)COc1ccc(NS(C)(=O)=O)cc1,J Med Chem,CHEMBL524038,0.13,Yes,6.886056648
CHEMBL1027247,Displacement of [3H]astemizole from human ERG expressed in HEK293 cells,CCN(CCc1ccc(Cl)c(Cl)c1)C[C@H](O)COc1ccc(NS(C)(=O)=O)cc1,J Med Chem,CHEMBL492620,0.17,Yes,6.769551079
CHEMBL1027247,Displacement of [3H]astemizole from human ERG expressed in HEK293 cells,CN(CCc1ccc(Cl)c(Cl)c1)C[C@H](O)COc1ccc(NS(C)(=O)=O)cc1,J Med Chem,CHEMBL523167,0.37,Yes,6.431798276
CHEMBL1033089,Inhibition of human ERG,COCC(=O)O[C@]1(CCN(C)CCCc2nc3ccccc3[nH]2)CCc2cc(F)ccc2[C@@H]1C(C)C,J Med Chem,CHEMBL45816,0.806,Yes,6.093664958
CHEMBL1033089,Inhibition of human ERG,CCC(C)C(C)CN1CCC(CNC(=O)c2cc(Cl)cc(Cl)c2)CC1,J Med Chem,CHEMBL522697,0.883,Yes,6.054039296
CHEMBL1033089,Inhibition of human ERG,O=C(NCC1CCN(Cc2ccc(Br)nc2)CC1)c1cc(Cl)cc(Cl)c1,J Med Chem,CHEMBL523535,0.655,Yes,6.1837587
CHEMBL1033089,Inhibition of human ERG,O=C(NCC1CCN(Cc2cccc(C(F)(F)F)c2)CC1)c1cc(Cl)cc(Cl)c1,J Med Chem,CHEMBL523525,0.483,Yes,6.316052869
CHEMBL1033089,Inhibition of human ERG,CC(C)(C)CCN1CCC(CNC(=O)Nc2cccc(Cl)c2)(c2ccccc2)CC1,J Med Chem,CHEMBL488294,0.088,Yes,7.055517328
CHEMBL1033089,Inhibition of human ERG,Cc1ccc(CN2CCC(CNC(=O)c3cc(Cl)cc(Cl)c3)CC2)cc1,J Med Chem,CHEMBL488295,0.135,Yes,6.869666232
CHEMBL949428,Inhibition of human cloned ERG,CCCCN(CCCC)CCC(O)c1cc2c(Cl)cc(Cl)cc2c2cc(C(F)(F)F)ccc12,J Med Chem,CHEMBL1107,0.04,Yes,7.397940009
CHEMBL950430,Inhibition of human ERG by electrophysiology assay,CC(=O)Nc1cc(-c2cccc(N3CCN(C)CC3)n2)nc(-n2nc(C)cc2C)n1,J Med Chem,CHEMBL486162,0.54,Yes,6.26760624
CHEMBL975252,Inhibition of human ERG by patch-clamp assay,Cc1ncc(C)c(C(=O)N2CCC([C@H](N)Cc3cc(F)c(F)cc3F)CC2)n1,Bioorg Med Chem Lett,CHEMBL485123,85,No,4.070581074
CHEMBL975252,Inhibition of human ERG by patch-clamp assay,Cc1nccnc1C(=O)N1CCC([C@H](N)Cc2cc(F)c(F)cc2F)CC1,Bioorg Med Chem Lett,CHEMBL485124,55,No,4.259637311
CHEMBL975252,Inhibition of human ERG by patch-clamp assay,N[C@H](Cc1cc(F)c(F)cc1F)C1CCN(C(=O)c2cnc3ncccn23)CC1,Bioorg Med Chem Lett,CHEMBL485125,59,No,4.229147988
CHEMBL1011901,Inhibition of human ERG by MK-0499 binding assay,O=C([C@@H]1C[C@H]1c1ccc(C(F)(F)F)cc1)N1CCN(S(=O)(=O)c2cc(-c3cn[nH]c3)cc(C(F)(F)F)c2)CC1,J Med Chem,CHEMBL519252,0.5,Yes,6.301029996
CHEMBL1011901,Inhibition of human ERG by MK-0499 binding assay,O=C([C@@H]1C[C@H]1c1ccc(C(F)(F)F)cc1)N1CCN(S(=O)(=O)c2cc(-c3ccn[nH]3)cc(C(F)(F)F)c2)CC1,J Med Chem,CHEMBL487708,0.5,Yes,6.301029996
CHEMBL1011901,Inhibition of human ERG by MK-0499 binding assay,O=C([C@@H]1C[C@H]1c1ccc(C(F)(F)F)cc1)N1CCN(S(=O)(=O)c2cc(C(O)C(F)(F)F)cc(C(F)(F)F)c2)CC1,J Med Chem,CHEMBL520543,0.06,Yes,7.22184875
CHEMBL1011901,Inhibition of human ERG by MK-0499 binding assay,O=C([C@@H]1C[C@H]1c1ccc(C(F)(F)F)cc1)N1CCN(S(=O)(=O)c2cc(CCO)cc(C(F)(F)F)c2)CC1,J Med Chem,CHEMBL490026,0.9,Yes,6.045757491
CHEMBL1011901,Inhibition of human ERG by MK-0499 binding assay,Cc1n[nH]cc1-c1cc(C(F)(F)F)cc(S(=O)(=O)N2CCN(C(=O)[C@@H]3C[C@H]3c3ccc(C(F)(F)F)cc3)CC2)c1,J Med Chem,CHEMBL487912,0.04,Yes,7.397940009
CHEMBL953933,Displacement of [35S]MK499 from human ERG in HEK293 cell membrane,Cc1nn(-c2ccccc2)cc1CN1CCC2(CC1)OCc1ccccc12,Bioorg Med Chem Lett,CHEMBL460893,0.74,Yes,6.13076828
CHEMBL952419,Antagonist activity at human ERG by voltage-clamp electrophysiology assay,CC(C)(C)CCN1CCC(CNC(=O)Nc2cccc(Cl)c2)(c2ccccc2)CC1,J Med Chem,CHEMBL488294,0.088,Yes,7.055517328
CHEMBL952419,Antagonist activity at human ERG by voltage-clamp electrophysiology assay,Cc1ccc(CN2CCC(CNC(=O)c3cc(Cl)cc(Cl)c3)CC2)cc1,J Med Chem,CHEMBL488295,0.135,Yes,6.869666232
CHEMBL947435,Inhibition of human ERG in embryonic kidney cells by radioligand-binding competition assay,CN(C)CCN1CCN(c2ncc3cc(-c4ccccc4)c(-c4ccc(CN5CCC(c6nnc(-c7ccc(=O)[nH]c7)[nH]6)CC5)cc4)nc3n2)CC1,Bioorg Med Chem Lett,CHEMBL503652,0.8,Yes,6.096910013
CHEMBL1020033,Displacement of [35S]MK499 from human ERG expressed in HEL cells,CN1CC[C@H](N(C)C(=O)N2CC(c3cc(F)ccc3F)=C[C@@]2(CO)c2ccccc2)[C@@H](F)C1,J Med Chem,CHEMBL481932,36.9,No,4.432973634
CHEMBL948532,Displacement of [35S]MK499 from human ERG K+ channel expressed in HEK293 cells,Cc1ccccc1C1CCN(C[C@H]2CCc3cccnc3[C@@H](O)C2)CC1,J Med Chem,CHEMBL471994,0.31,Yes,6.508638306
CHEMBL948532,Displacement of [35S]MK499 from human ERG K+ channel expressed in HEK293 cells,Cc1ccccc1C1CCN(C[C@H]2CCc3cccnc3[C@@H](O)C2)CC1,J Med Chem,CHEMBL471994,0.22,Yes,6.657577319
CHEMBL948532,Displacement of [35S]MK499 from human ERG K+ channel expressed in HEK293 cells,Cc1ccccc1C1CCN(C[C@@H]2CCc3c(C)cccc3[C@@H](O)C2)CC1,J Med Chem,CHEMBL513585,0.086,Yes,7.065501549
CHEMBL948532,Displacement of [35S]MK499 from human ERG K+ channel expressed in HEK293 cells,Cc1ccccc1[C@@H]1CCN(C[C@@H]2CCc3cccnc3[C@@H](O)C2)C[C@H]1O,J Med Chem,CHEMBL512896,40,No,4.397940009
CHEMBL948532,Displacement of [35S]MK499 from human ERG K+ channel expressed in HEK293 cells,O[C@H]1C[C@H](CN2CCC(c3c(Cl)cccc3Cl)CC2)CCc2cccnc21,J Med Chem,CHEMBL486644,0.94,Yes,6.026872146
CHEMBL984535,Displacement of [35S]MK-499 from human ERG expressed in HEK293 cells,Cc1noc(/C(=C/c2cccc(-c3cc(C(C)(C)S(C)(=O)=O)cc4cccnc34)c2)c2ccc(S(C)(=O)=O)cc2)n1,Bioorg Med Chem Lett,CHEMBL372575,49.9,No,4.301899454
CHEMBL984535,Displacement of [35S]MK-499 from human ERG expressed in HEK293 cells,O=C(Nc1c(Cl)cncc1Cl)c1cn(-c2ccc(Cl)cc2)c2ncccc2c1=O,Bioorg Med Chem Lett,CHEMBL456171,0.198,Yes,6.70333481
CHEMBL984535,Displacement of [35S]MK-499 from human ERG expressed in HEK293 cells,Cc1noc(/C(=C/c2cccc(-n3cc(C(=O)Nc4c(Cl)cncc4Cl)c(=O)c4cccnc43)c2)c2ccc(S(C)(=O)=O)cc2)n1,Bioorg Med Chem Lett,CHEMBL499477,0.68,Yes,6.167491087
CHEMBL984535,Displacement of [35S]MK-499 from human ERG expressed in HEK293 cells,CC(C)NC(=O)c1cn(-c2ccccc2)c2ncccc2c1=O,Bioorg Med Chem Lett,CHEMBL456173,71.5,No,4.145693958
CHEMBL984535,Displacement of [35S]MK-499 from human ERG expressed in HEK293 cells,CC(C)NC(=O)c1cn(-c2cccc(Br)c2)c2ncccc2c1=O,Bioorg Med Chem Lett,CHEMBL456172,31.6,No,4.500312917
CHEMBL984535,Displacement of [35S]MK-499 from human ERG expressed in HEK293 cells,CC(C)CNC(=O)c1cn(-c2cccc(Br)c2)c2ncccc2c1=O,Bioorg Med Chem Lett,CHEMBL464600,31.8,No,4.49757288
CHEMBL984535,Displacement of [35S]MK-499 from human ERG expressed in HEK293 cells,CC(=O)c1cccc(-c2cccc(-n3cc(C(=O)Nc4nccc(Cl)c4Cl)c(=O)c4cccnc43)c2)c1,Bioorg Med Chem Lett,CHEMBL514564,0.74,Yes,6.13076828
CHEMBL984535,Displacement of [35S]MK-499 from human ERG expressed in HEK293 cells,CSc1ccc(-c2cccc(-n3cc(C(=O)NC(C)C)c(=O)c4cccnc43)c2)cc1,Bioorg Med Chem Lett,CHEMBL485547,0.96,Yes,6.017728767
CHEMBL984535,Displacement of [35S]MK-499 from human ERG expressed in HEK293 cells,CC(C)(O)c1ccc(-c2cccc(-n3cc(C(=O)NC4CC4)c(=O)c4cccnc43)c2)cn1,Bioorg Med Chem Lett,CHEMBL520502,36.6,No,4.436518915
CHEMBL984535,Displacement of [35S]MK-499 from human ERG expressed in HEK293 cells,CC(C)(O)c1ccc(-c2cccc(-n3cc(C(=O)NC4CC4)c(=O)c4cccnc43)c2)c[n+]1[O-],Bioorg Med Chem Lett,CHEMBL485620,50.1,No,4.300162274
CHEMBL984535,Displacement of [35S]MK-499 from human ERG expressed in HEK293 cells,O=C(NC1CC1)c1cn(-c2cccc(C#Cc3ccc[n+]([O-])c3)c2)c2ncccc2c1=O,Bioorg Med Chem Lett,CHEMBL485629,65.7,No,4.18243463
CHEMBL984535,Displacement of [35S]MK-499 from human ERG expressed in HEK293 cells,CC(C)(O)c1ccc(C#Cc2cccc(-n3cc(C(=O)NC4CC4)c(=O)c4cccnc43)c2)c[n+]1[O-],Bioorg Med Chem Lett,CHEMBL520463,89.4,No,4.048662481
CHEMBL984535,Displacement of [35S]MK-499 from human ERG expressed in HEK293 cells,O=C(NC1CC1)c1cn(-c2cccc(-c3cccnc3)c2)c2ncccc2c1=O,Bioorg Med Chem Lett,CHEMBL519355,34,No,4.468521083
CHEMBL988836,Displacement of [3H]dofetilide from human ERG in HEK293 cells,CNC(=O)c1c(NCCC2CCCC2)nc(C#N)nc1OCC1CCN(C)CC1,Bioorg Med Chem Lett,CHEMBL478012,0.36,Yes,6.443697499
CHEMBL988836,Displacement of [3H]dofetilide from human ERG in HEK293 cells,CNC(=O)c1c(NCC2CCC3(CCC3)CC2)nc(C#N)nc1OCC1CCN(C(C)C)CC1,Bioorg Med Chem Lett,CHEMBL478013,0.54,Yes,6.26760624
CHEMBL988836,Displacement of [3H]dofetilide from human ERG in HEK293 cells,CNC(=O)c1c(NCC2CCC3(CCC3)CC2)nc(C#N)nc1OCC1CCN(CCO)CC1,Bioorg Med Chem Lett,CHEMBL514042,0.89,Yes,6.050609993
CHEMBL988836,Displacement of [3H]dofetilide from human ERG in HEK293 cells,CNC(=O)c1c(NCC2CCC3(CCC3)CC2)nc(C#N)nc1OCCC1CCN(C)CC1,Bioorg Med Chem Lett,CHEMBL478011,0.42,Yes,6.37675071
CHEMBL988836,Displacement of [3H]dofetilide from human ERG in HEK293 cells,CNC(=O)c1c(NCC2CCC3(CCC3)CC2)nc(C#N)nc1OCC1CCN(C)CC1,Bioorg Med Chem Lett,CHEMBL515025,0.71,Yes,6.148741651
CHEMBL1021966,"Displacement of [35S]N-[(4R)-1'-[(2R)-6-cyano-1,2,3,4-tetrahydro-2-naphthyl]-3,4-dihydro-4-hydroxyspiro[2H-1-benzopyran-2,4'-piperidin]6-yl]methanesulfonamide from human ERG expressed in HEK293 cells",N#Cc1ccnc(C2=NC(c3ccc(F)cc3)(c3ccc(F)cc3)CN2)c1,J Med Chem,CHEMBL522456,0.101,Yes,6.995678626
CHEMBL1021966,"Displacement of [35S]N-[(4R)-1'-[(2R)-6-cyano-1,2,3,4-tetrahydro-2-naphthyl]-3,4-dihydro-4-hydroxyspiro[2H-1-benzopyran-2,4'-piperidin]6-yl]methanesulfonamide from human ERG expressed in HEK293 cells",CC[C@@H]1NC(c2cc(C#N)ccn2)=NC1(c1ccc(F)cc1)c1ccc(F)cc1,J Med Chem,CHEMBL522793,0.49,Yes,6.30980392
CHEMBL1021966,"Displacement of [35S]N-[(4R)-1'-[(2R)-6-cyano-1,2,3,4-tetrahydro-2-naphthyl]-3,4-dihydro-4-hydroxyspiro[2H-1-benzopyran-2,4'-piperidin]6-yl]methanesulfonamide from human ERG expressed in HEK293 cells",CCC[C@@H]1NC(c2cc(C#N)ccn2)=NC1(c1ccc(F)cc1)c1ccc(F)cc1,J Med Chem,CHEMBL490949,0.49,Yes,6.30980392
CHEMBL1021997,Inhibition of human ERG,CC(C)CNc1nc(C#N)nc(N2CCNCC2)c1N,Bioorg Med Chem Lett,CHEMBL474484,52,No,4.283996656
CHEMBL1021997,Inhibition of human ERG,CC(C)(C)CNc1nc(C#N)nc(N2CCOCC2)c1N,Bioorg Med Chem Lett,CHEMBL471757,70,No,4.15490196
CHEMBL1022018,Inhibition of human ERG by patch-clamp technique,O=C([C@@H]1C[C@H](N2CCN(c3ncccn3)CC2)CN1)N1C[C@@H](F)[C@@H](F)C1,Bioorg Med Chem Lett,CHEMBL474421,54,No,4.26760624
CHEMBL1022018,Inhibition of human ERG by patch-clamp technique,O=C([C@@H]1C[C@H](N2CCN(c3ncccn3)CC2)CN1)N1CCC(F)(F)C1,Bioorg Med Chem Lett,CHEMBL515387,126,No,3.899629455
CHEMBL968701,Inhibition of human ERG expressed in HEK293 cells by patch-clamp method,CN(C)C(=N)c1ccc(C(=O)Nc2ccc(Cl)cc2C(=O)Nc2ccc(Cl)cn2)cc1,Bioorg Med Chem Lett,CHEMBL221906,0.33,Yes,6.48148606
CHEMBL986351,"Displacement of [35S]N-[(4R)-1'-[(2R)-6-cyano-1,2,3,4-tetrahydro-2-naphthalenyl]-3,4-dihydro-4-hydroxyspiro[2H-1-benzopyran-2,4'-piperidin]-6-yl]methanesulfonamide from human ERG in HEK293 cells",O=c1c2ccccc2ncn1-c1ccc(OCCCN2CCCC2)cc1,J Med Chem,CHEMBL518431,0.71,Yes,6.148741651
CHEMBL986351,"Displacement of [35S]N-[(4R)-1'-[(2R)-6-cyano-1,2,3,4-tetrahydro-2-naphthalenyl]-3,4-dihydro-4-hydroxyspiro[2H-1-benzopyran-2,4'-piperidin]-6-yl]methanesulfonamide from human ERG in HEK293 cells",Cc1nc2c(C(F)(F)F)cccc2c(=O)n1-c1ccc(OCCCN2CCCC2)cc1,J Med Chem,CHEMBL476322,0.35,Yes,6.455931956
CHEMBL978140,Inhibition of human ERG channel,COC(=O)C(CCCN(C)CCCc1nc2ccccc2[nH]1)(c1ccc(Br)cc1)C(C)C,Bioorg Med Chem Lett,CHEMBL468397,0.178,Yes,6.749579998
CHEMBL979037,Inhibition of human ERG potassium channel,CC(C)C(=O)N(Cc1ccc(Cl)cc1Cl)[C@H]1CCNC1,Bioorg Med Chem Lett,CHEMBL513139,40.2,No,4.395773947
CHEMBL976349,Displacement of radiolabeled dofetilide from human ERG,Fc1ccc(-c2noc(C3CCN(c4cnc5ccc(Cl)cc5c4)CC3)n2)c(Cl)c1,Bioorg Med Chem Lett,CHEMBL468176,0.5,Yes,6.301029996
CHEMBL981950,Displacement of [3H]astemizole from human ERG potassium channel expressed in HEK293 cell membrane,O=C1OCCN1C1CCN(CCc2ccc(Oc3nc4ccccc4s3)cc2)CC1,J Med Chem,CHEMBL482056,0.5,Yes,6.301029996
CHEMBL962309,Displacement of [3H]dofetilide from human ERG channel,CC(c1ccccc1Oc1ccc(Cl)c(Cl)c1)N(C)C,Bioorg Med Chem Lett,CHEMBL487053,0.9,Yes,6.045757491
CHEMBL962309,Displacement of [3H]dofetilide from human ERG channel,CNCc1ccc(Br)cc1Oc1ccc(Cl)c(Cl)c1,Bioorg Med Chem Lett,CHEMBL451137,0.974,Yes,6.011441043
CHEMBL962309,Displacement of [3H]dofetilide from human ERG channel,COc1ccc(CN(C)C)c(Oc2ccc(Cl)c(Cl)c2)c1,Bioorg Med Chem Lett,CHEMBL455423,0.234,Yes,6.630784143
CHEMBL962309,Displacement of [3H]dofetilide from human ERG channel,CNCc1ccc(OC)cc1Oc1ccc(Cl)c(Cl)c1,Bioorg Med Chem Lett,CHEMBL500329,0.692,Yes,6.159893906
CHEMBL962309,Displacement of [3H]dofetilide from human ERG channel,CNC(C)c1ccc(OC)cc1Oc1ccc(Cl)c(Cl)c1,Bioorg Med Chem Lett,CHEMBL527094,0.785,Yes,6.105130343
CHEMBL962309,Displacement of [3H]dofetilide from human ERG channel,CNCc1ccc(Cl)cc1Oc1ccc(Cl)cc1,Bioorg Med Chem Lett,CHEMBL462387,0.645,Yes,6.190440285
CHEMBL962309,Displacement of [3H]dofetilide from human ERG channel,CNCc1ccc(Cl)cc1Oc1ccc(F)c(C(F)(F)F)c1,Bioorg Med Chem Lett,CHEMBL453880,0.873,Yes,6.058985756
CHEMBL956578,Displacement of [35S]MK499 from human ERG expressed in HEK293 cells,Cn1c(-c2ccc(OC3CCN(C4CCC4)CC3)cc2)nc2c(C(F)(F)F)cccc2c1=O,Bioorg Med Chem Lett,CHEMBL453894,0.35,Yes,6.455931956
CHEMBL956578,Displacement of [35S]MK499 from human ERG expressed in HEK293 cells,O=c1c2ccccc2nc(-c2ccc(OCCCN3CCCCC3)cc2)n1-c1ccccc1,Bioorg Med Chem Lett,CHEMBL487060,0.46,Yes,6.337242168
CHEMBL956578,Displacement of [35S]MK499 from human ERG expressed in HEK293 cells,O=c1c2ccccc2nc(-c2ccc(OCCCN3CCCCC3)cc2)n1Cc1ccccc1,Bioorg Med Chem Lett,CHEMBL487059,0.17,Yes,6.769551079
CHEMBL1027290,Inhibition of human ERG,Nc1ccc(-c2ccccc2F)cc1NC(=O)c1ccc(CN2CCC3(CCCN3)CC2)cc1,Bioorg Med Chem Lett,CHEMBL473271,0.183,Yes,6.73754891
CHEMBL1027290,Inhibition of human ERG,Nc1ccc(-c2cccc(F)c2)cc1NC(=O)c1ccc(CN2CCC3(CCCN3)CC2)cc1,Bioorg Med Chem Lett,CHEMBL473475,0.167,Yes,6.777283529
CHEMBL1027290,Inhibition of human ERG,Nc1ccc(-c2ccc(F)cc2)cc1NC(=O)c1ccc(CN2CCC3(CCNC3)CC2)cc1,Bioorg Med Chem Lett,CHEMBL473478,0.237,Yes,6.625251654
CHEMBL1023104,Inhibition of human ERG,CN(C)C(=O)[C@@H](c1ccc(C2=CN3N=CNC3C=C2)cc1)[C@H](N)C(=O)N1CC[C@H](F)C1,Bioorg Med Chem,CHEMBL459357,86,No,4.065501549
CHEMBL1023104,Inhibition of human ERG,CC(C)[C@H](Oc1ccc(CNC(=O)[C@@H]2CCCN2C(=O)C[C@H](N)Cc2cc(F)ccc2F)cc1)C(=O)O.O=C(O)C(F)(F)F,Bioorg Med Chem,CHEMBL445949,76,No,4.119186408
CHEMBL1011672,Inhibition of wild-type human ERG expressed in HEK293 cells by whole cell patch clamp method,COc1cc(N)c(Cl)cc1C(=O)NC1CCN(CCCOc2ccc(F)cc2)CC1OC,J Med Chem,CHEMBL1729,0.01,Yes,8
CHEMBL1011672,Inhibition of wild-type human ERG expressed in HEK293 cells by whole cell patch clamp method,Cc1cccc(CCN2CCC(C(=O)c3ccc(NS(C)(=O)=O)cc3)CC2)n1.Cl.Cl,J Med Chem,CHEMBL536480,0.02,Yes,7.698970004
CHEMBL1011672,Inhibition of wild-type human ERG expressed in HEK293 cells by whole cell patch clamp method,CC(C)(C)c1ccc(C(O)CCCN2CCC(C(O)(c3ccccc3)c3ccccc3)CC2)cc1,J Med Chem,CHEMBL17157,0.03,Yes,7.522878745
CHEMBL1011674,Inhibition of human ERG Y652A mutant expressed in HEK293 cells by whole cell patch clamp method,CC(C)(C)c1ccc(C(O)CCCN2CCC(C(O)(c3ccccc3)c3ccccc3)CC2)cc1,J Med Chem,CHEMBL17157,0.35,Yes,6.455931956
CHEMBL1011676,Inhibition of human ERG F656A mutant expressed in HEK293 cells by whole cell patch clamp method,CC(C)(C)c1ccc(C(O)CCCN2CCC(C(O)(c3ccccc3)c3ccccc3)CC2)cc1,J Med Chem,CHEMBL17157,0.96,Yes,6.017728767
CHEMBL1011677,Inhibition of human ERG S624A mutant expressed in HEK293 cells by whole cell patch clamp method,COc1cc(N)c(Cl)cc1C(=O)NC1CCN(CCCOc2ccc(F)cc2)CC1OC,J Med Chem,CHEMBL1729,0.12,Yes,6.920818754
CHEMBL1011677,Inhibition of human ERG S624A mutant expressed in HEK293 cells by whole cell patch clamp method,Cc1cccc(CCN2CCC(C(=O)c3ccc(NS(C)(=O)=O)cc3)CC2)n1.Cl.Cl,J Med Chem,CHEMBL536480,0.69,Yes,6.161150909
CHEMBL1011677,Inhibition of human ERG S624A mutant expressed in HEK293 cells by whole cell patch clamp method,CC(C)(C)c1ccc(C(O)CCCN2CCC(C(O)(c3ccccc3)c3ccccc3)CC2)cc1,J Med Chem,CHEMBL17157,0.03,Yes,7.522878745
CHEMBL1011678,Inhibition of human ERG expressed in HEK293 cells by whole cell patch clamp method,CC(C)(C(=O)O)c1ccc(C(O)CCCN2CCC(C(O)(c3ccccc3)c3ccccc3)CC2)cc1,J Med Chem,CHEMBL914,65,No,4.187086643
CHEMBL1034067,Displacement of [3H]dofetilide from human ERG expressed in HEK293 cells,CC(C[C@H](NC(=O)C1CCC1)c1ccccc1)N1CCC(n2cc(-c3ccccc3)[nH]c2=O)CC1,Bioorg Med Chem Lett,CHEMBL460009,0.0047,Yes,8.327902142
CHEMBL1034067,Displacement of [3H]dofetilide from human ERG expressed in HEK293 cells,CC(C[C@H](NC(=O)C1CCC1)c1ccccc1)N1CCC(c2[nH]ncc2-c2ccncc2)CC1,Bioorg Med Chem Lett,CHEMBL460217,0.117,Yes,6.931814138
CHEMBL1034067,Displacement of [3H]dofetilide from human ERG expressed in HEK293 cells,CCN(C(=O)Cc1ccc(OC)cc1)[C@H]1C[C@H]2CC[C@@H](C1)N2CC[C@H](NC(=O)C1CCC1)c1ccccc1,Bioorg Med Chem Lett,CHEMBL456019,0.248,Yes,6.605548319
CHEMBL1034067,Displacement of [3H]dofetilide from human ERG expressed in HEK293 cells,Cc1nnc(C)n1C1CCN(C(C)C[C@H](NC(=O)C2CCC2)c2ccccc2)CC1,Bioorg Med Chem Lett,CHEMBL469542,0.849,Yes,6.07109231
CHEMBL1036648,Inhibition of human ERG channel in HEK293 cells by voltage-clamp method,O=C(CCCN1CC=C(n2c(=O)[nH]c3ccccc32)CC1)c1ccc(F)cc1,Eur J Med Chem,CHEMBL1108,0.03236,Yes,7.489991487
CHEMBL1036648,Inhibition of human ERG channel in HEK293 cells by voltage-clamp method,Fc1ccc(Cn2c(NC3CCNCC3)nc3ccccc32)cc1,Eur J Med Chem,CHEMBL61301,0.02754,Yes,7.560036064
CHEMBL1036648,Inhibition of human ERG channel in HEK293 cells by voltage-clamp method,Cc1cccc(CCN2CCC(C(=O)c3ccc(NS(C)(=O)=O)cc3)CC2)n1,Eur J Med Chem,CHEMBL327980,0.02291,Yes,7.639974911
CHEMBL1036648,Inhibition of human ERG channel in HEK293 cells by voltage-clamp method,CS(=O)(=O)Nc1ccc2c(c1)[C@H](O)CC1(CCN([C@@H]3CCc4cc(C#N)ccc4C3)CC1)O2,Eur J Med Chem,CHEMBL477015,0.02138,Yes,7.669992299
CHEMBL1036648,Inhibition of human ERG channel in HEK293 cells by voltage-clamp method,O=c1[nH]c2ccccc2n1C1CCN(CCCC(c2ccc(F)cc2)c2ccc(F)cc2)CC1,Eur J Med Chem,CHEMBL1423,0.00302,Yes,8.519993057
CHEMBL1036648,Inhibition of human ERG channel in HEK293 cells by voltage-clamp method,Oc1ccc(CCN2CCC(Nc3nc4ccccc4n3Cc3ccc(F)cc3)CC2)cc1,Eur J Med Chem,CHEMBL60796,0.001,Yes,9
CHEMBL1036648,Inhibition of human ERG channel in HEK293 cells by voltage-clamp method,CN(CCOc1ccc(NS(C)(=O)=O)cc1)CCc1ccc(NS(C)(=O)=O)cc1,Eur J Med Chem,CHEMBL473,0.04898,Yes,7.309981219
CHEMBL1036648,Inhibition of human ERG channel in HEK293 cells by voltage-clamp method,O=c1[nH]c2ccccc2n1CCCN1CCC(n2c(=O)[nH]c3cc(Cl)ccc32)CC1,Eur J Med Chem,CHEMBL219916,0.05754,Yes,7.240030142
CHEMBL1036648,Inhibition of human ERG channel in HEK293 cells by voltage-clamp method,CCC1(c2ccccc2)C(=O)NC(=O)NC1=O,Eur J Med Chem,CHEMBL40,3019.95172,No,2.52
CHEMBL1036648,Inhibition of human ERG channel in HEK293 cells by voltage-clamp method,CCN(CC)CC(=O)Nc1c(C)cccc1C,Eur J Med Chem,CHEMBL79,263.0268,No,3.579999999
CHEMBL1036648,Inhibition of human ERG channel in HEK293 cells by voltage-clamp method,CN1CCC[C@H]1c1cccnc1,Eur J Med Chem,CHEMBL3,245.47089,No,3.610000003
CHEMBL1036648,Inhibition of human ERG channel in HEK293 cells by voltage-clamp method,Nc1nnc(-c2cccc(Cl)c2Cl)c(N)n1,Eur J Med Chem,CHEMBL741,229.08677,No,3.639999991
CHEMBL1036648,Inhibition of human ERG channel in HEK293 cells by voltage-clamp method,COC(=O)C1=CC[C@@H]2CC[C@H]1N2C,Eur J Med Chem,CHEMBL451136,169.82437,No,3.769999988
CHEMBL1036648,Inhibition of human ERG channel in HEK293 cells by voltage-clamp method,CN1CC(=O)N2[C@H](c3ccc4c(c3)OCO4)c3[nH]c4ccccc4c3C[C@@H]2C1=O,Eur J Med Chem,CHEMBL779,100,No,4
CHEMBL1036648,Inhibition of human ERG channel in HEK293 cells by voltage-clamp method,CCOC(=O)C1(c2ccccc2)CCN(C)CC1,Eur J Med Chem,CHEMBL607,75.85776,No,4.119999986
CHEMBL1007470,Displacement of [35S]MK499 from human ERG expressed in HEK293 cells,Cc1c(CNC(C)C)nn(-c2ccc(Cl)cc2Cl)c1-c1ccc(Cl)cc1,Bioorg Med Chem Lett,CHEMBL494230,0.023,Yes,7.638272164
CHEMBL1007470,Displacement of [35S]MK499 from human ERG expressed in HEK293 cells,Cc1c(CNC2CCCC2)nn(-c2ccc(Cl)cc2Cl)c1-c1ccc(Cl)cc1,Bioorg Med Chem Lett,CHEMBL512827,0.023,Yes,7.638272164
CHEMBL1007470,Displacement of [35S]MK499 from human ERG expressed in HEK293 cells,Cc1ncc(-c2c(C)c(CN[C@H]3CC[C@@H](F)C3)nn2-c2ncccc2Cl)cc1F,Bioorg Med Chem Lett,CHEMBL466648,41,No,4.387216143
CHEMBL972465,Displacement of [35S]MK499 from human ERG expressed in HEK293 cells,CCN1CCN(c2cc3[nH]c(SC(C)(C)C)nc3cc2Cl)[C@H](C)C1,Bioorg Med Chem Lett,CHEMBL468504,0.99,Yes,6.004364805
CHEMBL972465,Displacement of [35S]MK499 from human ERG expressed in HEK293 cells,CCN1CCN(c2cc3[nH]c(S[C@]4(C)CC[C@@H](c5nc(C)no5)CC4)nc3cc2Cl)CC1,Bioorg Med Chem Lett,CHEMBL466252,0.38,Yes,6.420216403
CHEMBL1023674,Inhibition of human ERG in MCF7 cells,CN1CCN(CCCCN2C(=O)CN(/N=C/c3ccc(-c4ccc(Cl)cc4)o3)C2=O)CC1,Eur J Med Chem,CHEMBL123558,0.56234,Yes,6.250001023
CHEMBL1023674,Inhibition of human ERG in MCF7 cells,CC(C)COCC(CN(Cc1ccccc1)c1ccccc1)N1CCCC1,Eur J Med Chem,CHEMBL1008,0.54954,Yes,6.260000691
CHEMBL1023674,Inhibition of human ERG in MCF7 cells,CN(c1nccc(=O)[nH]1)C1CCN(c2nc3ccccc3n2Cc2ccc(F)cc2)CC1,Eur J Med Chem,CHEMBL94454,0.35481,Yes,6.450004148
CHEMBL1023674,Inhibition of human ERG in MCF7 cells,CCCCN(CCCC)CCC(O)c1cc2c(Cl)cc(Cl)cc2c2cc(C(F)(F)F)ccc12,Eur J Med Chem,CHEMBL1107,0.19953,Yes,6.699991797
CHEMBL1023674,Inhibition of human ERG in MCF7 cells,CCOC(=O)N1CCC(=C2c3ccc(Cl)cc3CCc3cccnc32)CC1,Eur J Med Chem,CHEMBL998,0.17378,Yes,6.760000207
CHEMBL1023674,Inhibition of human ERG in MCF7 cells,O=c1[nH]c2ccccc2n1CCCN1CCC(n2c(=O)[nH]c3cc(Cl)ccc32)CC1,Eur J Med Chem,CHEMBL219916,0.16218,Yes,6.790002704
CHEMBL1023674,Inhibition of human ERG in MCF7 cells,COc1ccc(CCN(C)CCCC(C#N)(c2ccc(OC)c(OC)c2)C(C)C)cc1OC,Eur J Med Chem,CHEMBL6966,0.14454,Yes,6.84001195
CHEMBL1023674,Inhibition of human ERG in MCF7 cells,CC(C)(C)c1ccc(C(O)CCCN2CCC(C(O)(c3ccccc3)c3ccccc3)CC2)cc1,Eur J Med Chem,CHEMBL17157,0.12882,Yes,6.890016705
CHEMBL1023674,Inhibition of human ERG in MCF7 cells,CSc1ccc2c(c1)N(CCC1CCCCN1C)c1ccccc1S2,Eur J Med Chem,CHEMBL479,0.03548,Yes,7.450016389
CHEMBL1023674,Inhibition of human ERG in MCF7 cells,O=C(CCCN1CC=C(n2c(=O)[nH]c3ccccc32)CC1)c1ccc(F)cc1,Eur J Med Chem,CHEMBL1108,0.03236,Yes,7.489991487
CHEMBL1023674,Inhibition of human ERG in MCF7 cells,O=C(CCCN1CCC(O)(c2ccc(Cl)cc2)CC1)c1ccc(F)cc1,Eur J Med Chem,CHEMBL54,0.02818,Yes,7.550059011
CHEMBL1023674,Inhibition of human ERG in MCF7 cells,O=c1[nH]c2ccccc2n1C1CCN(CCCC(c2ccc(F)cc2)c2ccc(F)cc2)CC1,Eur J Med Chem,CHEMBL1423,0.0182,Yes,7.739928612
CHEMBL1023674,Inhibition of human ERG in MCF7 cells,O=C1NCCN1CCN1CCC(c2cn(-c3ccc(F)cc3)c3ccc(Cl)cc23)CC1,Eur J Med Chem,CHEMBL12713,0.01413,Yes,7.849857838
CHEMBL1023674,Inhibition of human ERG in MCF7 cells,CN(CCOc1ccc(NS(C)(=O)=O)cc1)CCc1ccc(NS(C)(=O)=O)cc1,Eur J Med Chem,CHEMBL473,0.0123,Yes,7.910094889
CHEMBL1023674,Inhibition of human ERG in MCF7 cells,Cc1cccc(CCN2CCC(C(=O)c3ccc(NS(C)(=O)=O)cc3)CC2)n1,Eur J Med Chem,CHEMBL327980,0.007762,Yes,8.110026362
CHEMBL1023674,Inhibition of human ERG in MCF7 cells,COc1cc(N)c(Cl)cc1C(=O)NC1CCN(CCCOc2ccc(F)cc2)CC1OC,Eur J Med Chem,CHEMBL1729,0.006457,Yes,8.189969214
CHEMBL1023674,Inhibition of human ERG in MCF7 cells,COc1ccc(CCN2CCC(Nc3nc4ccccc4n3Cc3ccc(F)cc3)CC2)cc1,Eur J Med Chem,CHEMBL296419,0.000912,Yes,9.040005162
CHEMBL1023674,Inhibition of human ERG in MCF7 cells,COc1ccc(Cl)cc1C(=O)NCCc1ccc(S(=O)(=O)NC(=O)NC2CCCCC2)cc1,Eur J Med Chem,CHEMBL472,74.13102,No,4.130000024
CHEMBL1023674,Inhibition of human ERG in MCF7 cells,Cc1c(F)c(N2CCNC(C)C2)cc2c1c(=O)c(C(=O)O)cn2C1CC1,Eur J Med Chem,CHEMBL583,77.62471,No,4.110000009
CHEMBL1023674,Inhibition of human ERG in MCF7 cells,CCCc1nn(C)c2c(=O)[nH]c(-c3cc(S(=O)(=O)N4CCN(C)CC4)ccc3OCC)nc12,Eur J Med Chem,CHEMBL192,100,No,4
CHEMBL1023674,Inhibition of human ERG in MCF7 cells,COc1c(N2C[C@@H]3CCCN[C@@H]3C2)c(F)cc2c(=O)c(C(=O)O)cn(C3CC3)c12,Eur J Med Chem,CHEMBL32,117.48976,No,3.929999983
CHEMBL1023674,Inhibition of human ERG in MCF7 cells,COc1c(N2CCNC(C)C2)c(F)cc2c(=O)c(C(=O)O)cn(C3CC3)c12,Eur J Med Chem,CHEMBL31,128.82496,No,3.889999984
CHEMBL1023674,Inhibition of human ERG in MCF7 cells,Fc1ccc(Cn2c(NC3CCNCC3)nc3ccccc32)cc1,Eur J Med Chem,CHEMBL61301,0.02818,Yes,7.550059011
CHEMBL1023674,Inhibition of human ERG in MCF7 cells,O=C1Cc2cc(CCN3CCN(c4nsc5ccccc45)CC3)c(Cl)cc2N1,Eur J Med Chem,CHEMBL708,0.15136,Yes,6.819988881
CHEMBL1023674,Inhibition of human ERG in MCF7 cells,Cc1nc2n(c(=O)c1CCN1CCC(c3noc4cc(F)ccc34)CC1)CCCC2,Eur J Med Chem,CHEMBL85,0.16218,Yes,6.790002704
CHEMBL1023674,Inhibition of human ERG in MCF7 cells,CN1CCN(C2=Nc3cc(Cl)ccc3Nc3ccccc32)CC1,Eur J Med Chem,CHEMBL42,0.19055,Yes,6.719991047
CHEMBL1023476,Inhibition human ERG expressed in HEK293 cells assessed as blockade of membrane current by patch clamp method,Cn1cnc(C(=O)N(Cc2cccc(OC(F)(F)F)c2)C[C@H]2[C@@H]3CN(CC4CC4)C[C@@H]32)c1,Bioorg Med Chem Lett,CHEMBL560750,0.53,Yes,6.27572413
CHEMBL1023476,Inhibition human ERG expressed in HEK293 cells assessed as blockade of membrane current by patch clamp method,Cn1cnc(C(=O)N(Cc2cccc(OC(F)(F)F)c2)C[C@H]2[C@@H]3CN(CC4CCCC4)C[C@@H]32)c1,Bioorg Med Chem Lett,CHEMBL563220,0.46,Yes,6.337242168
CHEMBL1023476,Inhibition human ERG expressed in HEK293 cells assessed as blockade of membrane current by patch clamp method,Cn1cnc(C(=O)N(Cc2cccc(Cl)c2)[C@H]2CC[C@@H](N)CC2)c1,Bioorg Med Chem Lett,CHEMBL563761,65.6,No,4.183096161
CHEMBL1052984,Inhibition of human ERG channel,CC[C@H]1CN2CC[C@]3(C(=O)Nc4ccccc43)[C@@H]2C[C@@H]1/C(=C\OC)C(=O)OC,J Nat Prod,CHEMBL519266,773,No,3.111820506
CHEMBL1024556,Inhibition of human ERG channel,Clc1cccc(OC(c2ccccc2)C2CCNCC2)c1Cl,Bioorg Med Chem Lett,CHEMBL541226,0.95,Yes,6.022276395
CHEMBL1063190,Inhibition of human ERG expressed in CHO cells by patch clamp assay,O=C(CN1CCN(Cc2ccn(-c3ccc(C(F)(F)F)cn3)c2)CC1)NC(c1ccc(F)cc1)c1ccc(F)cc1,Bioorg Med Chem Lett,CHEMBL541944,0.8,Yes,6.096910013
CHEMBL1063190,Inhibition of human ERG expressed in CHO cells by patch clamp assay,O=C(CC1CCN(Cc2ccn(-c3ccc(C(F)(F)F)cn3)c2)CC1)NC(c1ccc(F)cc1)c1ccc(F)cc1,Bioorg Med Chem Lett,CHEMBL538936,0.8,Yes,6.096910013
CHEMBL1063190,Inhibition of human ERG expressed in CHO cells by patch clamp assay,O=C(CC1CCN(Cc2ccn(-c3ccc(C(F)(F)F)cc3)c2)CC1)N(CCCO)Cc1ccc(F)cc1,Bioorg Med Chem Lett,CHEMBL549635,0.63,Yes,6.200659451
CHEMBL1063190,Inhibition of human ERG expressed in CHO cells by patch clamp assay,O=C(CC1CCN(Cc2ccn(-c3ccc(C(F)(F)F)cc3)c2)CC1)N1CCCC(C(=O)N2CCCC2)C1,Bioorg Med Chem Lett,CHEMBL564032,31,No,4.508638306
CHEMBL1063190,Inhibition of human ERG expressed in CHO cells by patch clamp assay,O=C(COc1cccc(Cl)c1)NC1CCN(Cc2ccn(-c3ccc(C(F)(F)F)cc3)c2)CC1,Bioorg Med Chem Lett,CHEMBL472363,0.56,Yes,6.251811973
CHEMBL1061548,Inhibition of [35S]MK499 binding to human ERG transfected in HEK293 cells by microscintillation counting,C[C@@H]1Sc2ccccc2O[C@@H]1c1ccc(OCCCN2CCCC2)cc1,Bioorg Med Chem Lett,CHEMBL557853,0.005,Yes,8.301029996
CHEMBL1061548,Inhibition of [35S]MK499 binding to human ERG transfected in HEK293 cells by microscintillation counting,CC[C@@H]1Sc2ccccc2O[C@@H]1c1ccc(OCCCN2CCCC2)cc1,Bioorg Med Chem Lett,CHEMBL549433,0.011,Yes,7.958607315
CHEMBL1061548,Inhibition of [35S]MK499 binding to human ERG transfected in HEK293 cells by microscintillation counting,c1ccc([C@@H]2Sc3ccccc3O[C@@H]2c2ccc(OCCCN3CCCC3)cc2)cc1,Bioorg Med Chem Lett,CHEMBL564514,0.012,Yes,7.920818754
CHEMBL1061548,Inhibition of [35S]MK499 binding to human ERG transfected in HEK293 cells by microscintillation counting,C[C@H]1Sc2ccccc2O[C@@H]1c1ccc(OCCCN2CCCC2)cc1,Bioorg Med Chem Lett,CHEMBL550393,0.025,Yes,7.602059991
CHEMBL1061548,Inhibition of [35S]MK499 binding to human ERG transfected in HEK293 cells by microscintillation counting,CC1=C(c2ccc(OCCCN3CCCC3)cc2)Oc2ccccc2S1,Bioorg Med Chem Lett,CHEMBL560923,0.0044,Yes,8.356547324
CHEMBL1061548,Inhibition of [35S]MK499 binding to human ERG transfected in HEK293 cells by microscintillation counting,C[C@H]1[C@@H](c2ccc(OCCCN3CCCC3)cc2)Oc2ccccc2S1(=O)=O,Bioorg Med Chem Lett,CHEMBL549908,0.44,Yes,6.356547324
CHEMBL1061548,Inhibition of [35S]MK499 binding to human ERG transfected in HEK293 cells by microscintillation counting,CC1=C(c2ccc(OCCCN3CCCC3)cc2)Oc2ccccc2S1(=O)=O,Bioorg Med Chem Lett,CHEMBL556100,0.47,Yes,6.327902142
CHEMBL1057876,Displacement of [3H]dofetilide from human ERG channel by scintillation proximity assay,O=C1N(CCN2Cc3ccccc3C2)CCN1c1cccc(C(F)(F)F)c1,Bioorg Med Chem Lett,CHEMBL559029,0.79433,Yes,6.099999035
CHEMBL1057876,Displacement of [3H]dofetilide from human ERG channel by scintillation proximity assay,O=C1N(CCN2Cc3ccccc3C2)CCN1c1cccc(OC(F)(F)F)c1,Bioorg Med Chem Lett,CHEMBL565017,0.63096,Yes,6.199998172
CHEMBL1057876,Displacement of [3H]dofetilide from human ERG channel by scintillation proximity assay,Cc1ccc(N2CCN(CCN3Cc4ccccc4C3)C2=O)s1,Bioorg Med Chem Lett,CHEMBL552460,31.62278,No,4.499999953
CHEMBL1057876,Displacement of [3H]dofetilide from human ERG channel by scintillation proximity assay,Cc1ccc(N2CCN(CCN3Cc4ccccc4C3)C2=O)cn1,Bioorg Med Chem Lett,CHEMBL564477,31.62278,No,4.499999953
CHEMBL1057876,Displacement of [3H]dofetilide from human ERG channel by scintillation proximity assay,O=C1N(CCN2Cc3ccccc3C2)CCN1Cc1ccc(Cl)c(Cl)c1,Bioorg Med Chem Lett,CHEMBL560650,0.79433,Yes,6.099999035
CHEMBL1057876,Displacement of [3H]dofetilide from human ERG channel by scintillation proximity assay,O=C1N(CCN2Cc3ccccc3C2)CCN1Cc1cc(Cl)ccc1Cl,Bioorg Med Chem Lett,CHEMBL552367,0.39811,Yes,6.399996913
CHEMBL1057876,Displacement of [3H]dofetilide from human ERG channel by scintillation proximity assay,O=C1N(CCN2CCC(C(F)(F)F)CC2)CCN1c1cccc(I)c1,Bioorg Med Chem Lett,CHEMBL560574,0.19953,Yes,6.699991797
CHEMBL1057876,Displacement of [3H]dofetilide from human ERG channel by scintillation proximity assay,COc1cccc(N2CCN(CCN3CCN(C(C)C)CC3)C2=O)c1,Bioorg Med Chem Lett,CHEMBL550358,63.09573,No,4.200000031
CHEMBL1063998,Inhibition of human ERG,COc1cccnc1C(=O)N1CCN(c2ccc(NC(=O)C(C)(C)c3ccccc3)cc2Cl)CC1.Cl,Bioorg Med Chem Lett,CHEMBL557502,50.11872,No,4.300000029
CHEMBL1055593,Displacement of [35S]MK499 from human ERG channel in HEK293 cells,CCNc1cc(N2CCOCC2)cc(CCc2nc(C)c(CC)o2)n1,Bioorg Med Chem Lett,CHEMBL564513,0.4,Yes,6.397940009
CHEMBL1055593,Displacement of [35S]MK499 from human ERG channel in HEK293 cells,CCc1oc(CCc2cc(N3CCOCC3)cc(NC)n2)nc1C,Bioorg Med Chem Lett,CHEMBL571013,0.83,Yes,6.080921908
CHEMBL1055593,Displacement of [35S]MK499 from human ERG channel in HEK293 cells,CCCNc1cc(N2CCOCC2)cc(CCc2nc(C)c(CC)o2)n1,Bioorg Med Chem Lett,CHEMBL559593,0.48,Yes,6.318758763
CHEMBL1055593,Displacement of [35S]MK499 from human ERG channel in HEK293 cells,CCc1oc(CCc2cc(N3CCOCC3)cc(NC(C)C)n2)nc1C,Bioorg Med Chem Lett,CHEMBL557648,0.54,Yes,6.26760624
CHEMBL1055593,Displacement of [35S]MK499 from human ERG channel in HEK293 cells,CCc1oc(CCc2cc(N3CCOCC3)cc(NCCOC)n2)nc1C,Bioorg Med Chem Lett,CHEMBL562677,0.9,Yes,6.045757491
CHEMBL1055593,Displacement of [35S]MK499 from human ERG channel in HEK293 cells,CCOC(=O)CNc1cc(N2CCOCC2)cc(CCc2nc(C)c(CC)o2)n1,Bioorg Med Chem Lett,CHEMBL562831,0.91,Yes,6.040958608
CHEMBL1055593,Displacement of [35S]MK499 from human ERG channel in HEK293 cells,CCc1sc(CCc2cc(N3CCOCC3)cc(NC(C)c3cc(Cl)cc(NC(=O)OC(C)C)c3)n2)nc1C,Bioorg Med Chem Lett,CHEMBL564536,0.036,Yes,7.443697499
CHEMBL1056550,Inhibition of human ERG channel expressed in HEK293 cells by voltage clamp assay,O=C(c1ccc(C2=CC3(CCNCC3)Oc3ccccc32)cc1)N1CCOCC1,J Med Chem,CHEMBL551414,54.256,No,4.265552228
CHEMBL1056550,Inhibition of human ERG channel expressed in HEK293 cells by voltage clamp assay,CCN(CC)C(=O)c1ccc(C2=CC3(CCNCC3)Oc3ccccc32)cn1,J Med Chem,CHEMBL557054,44.113,No,4.355433406
CHEMBL1056550,Inhibition of human ERG channel expressed in HEK293 cells by voltage clamp assay,CCN(CC)C(=O)c1ccc(C2=CC3(CCNCC3)Oc3ccccc32)nc1,J Med Chem,CHEMBL561138,71.666,No,4.144686835
CHEMBL1056550,Inhibition of human ERG channel expressed in HEK293 cells by voltage clamp assay,CCN(CC)C(=O)c1ccc(C2=CC3(CCNCC3)Oc3ccccc32)c(F)c1,J Med Chem,CHEMBL559414,0.418,Yes,6.378823718
CHEMBL1056550,Inhibition of human ERG channel expressed in HEK293 cells by voltage clamp assay,CCN(CC)C(=O)c1ccc(C2=CC3(CCNCC3)Oc3ccccc32)c(O)c1,J Med Chem,CHEMBL561339,56.7,No,4.246416941
CHEMBL1051824,Inhibition of human ERG expressed in HEK293 cells by patch-clamp technique,C[C@H](C1=C(CCN(C)C)Cc2ccccc21)c1ccccn1,J Med Chem,CHEMBL564226,0.9,Yes,6.045757491
CHEMBL1053229,Displacement of [35S]MK499 from human ERG potassium channel expressed in HEK293 cells,COc1ccc(CN[C@@H]2CC[C@@H](C(=O)N3CCC(C(=O)N4CCCC4)(c4ccccc4)CC3)C(C)(C)C2)cc1,Bioorg Med Chem Lett,CHEMBL557932,0.9,Yes,6.045757491
CHEMBL1053229,Displacement of [35S]MK499 from human ERG potassium channel expressed in HEK293 cells,COc1ccc([C@@H](C)N[C@@H]2CC[C@@H](C(=O)N3CCC(c4ccccc4)(c4ccc(OC)nc4)CC3)C(C)(C)C2)cc1,Bioorg Med Chem Lett,CHEMBL171377,0.52,Yes,6.283996656
CHEMBL1053229,Displacement of [35S]MK499 from human ERG potassium channel expressed in HEK293 cells,COc1ccc([C@@H](C)N[C@@H]2CC[C@@H](C(=O)N3CCC(c4ccccc4)(c4ccccc4)CC3)C(C)(C)C2)cc1,Bioorg Med Chem Lett,CHEMBL549851,0.53,Yes,6.27572413
CHEMBL1059781,Displacement of [35S]MK499 from human ERG expressed in HEK293 cells overexpressing Ikr channel protein,Cc1ccc(-n2c(-c3ncccc3Cl)nc(CN[C@H]3CC[C@@H](F)C3)c2C)cn1,Bioorg Med Chem Lett,CHEMBL551208,31,No,4.508638306
CHEMBL1059781,Displacement of [35S]MK499 from human ERG expressed in HEK293 cells overexpressing Ikr channel protein,Cc1nc(CN[C@H]2CC[C@@H](F)C2)c(C(C)C)n1-c1cc(F)cc(F)c1,Bioorg Med Chem Lett,CHEMBL556300,34,No,4.468521083
CHEMBL1054110,Inhibition of human ERG,CS(=O)(=O)c1ccc2c(c1)nc1n2C[C@H](N)[C@@H](c2cc(F)c(F)cc2F)C1.O=C(O)C(F)(F)F,Bioorg Med Chem Lett,CHEMBL559940,38,No,4.420216403
CHEMBL1054110,Inhibition of human ERG,N[C@H]1Cn2c(nc3cnc(C(F)(F)F)cc32)C[C@@H]1c1cc(F)c(F)cc1F.O=C(O)C(F)(F)F.O=C(O)C(F)(F)F,Bioorg Med Chem Lett,CHEMBL541438,57,No,4.244125144
CHEMBL1054110,Inhibition of human ERG,N[C@H]1Cn2c(nc3cnccc32)C[C@@H]1c1cc(F)c(F)cc1F.O=C(O)C(F)(F)F.O=C(O)C(F)(F)F,Bioorg Med Chem Lett,CHEMBL562188,89,No,4.050609993
CHEMBL1054110,Inhibition of human ERG,N[C@H]1Cn2c(nc3cnc(F)cc32)C[C@@H]1c1cc(F)c(F)cc1F.O=C(O)C(F)(F)F.O=C(O)C(F)(F)F,Bioorg Med Chem Lett,CHEMBL559477,81,No,4.091514981
CHEMBL1054110,Inhibition of human ERG,N[C@H]1Cn2c(nc3ncccc32)C[C@@H]1c1cc(F)c(F)cc1F.O=C(O)C(F)(F)F.O=C(O)C(F)(F)F,Bioorg Med Chem Lett,CHEMBL562388,90,No,4.045757491
CHEMBL1059865,Displacement of [3H]dofetilide from human ERG channel by scintillation proximity assay,C[C@@]12CC(c3ccccc3)C[C@@H](C1)N(CCN1CCN(c3cccc(Cl)c3)C1=O)C2,Bioorg Med Chem Lett,CHEMBL551927,0.0631,Yes,7.199970641
CHEMBL1059865,Displacement of [3H]dofetilide from human ERG channel by scintillation proximity assay,O=C1N(CCN2C[C@H]3CC[C@H](CC3)C2)CCN1c1cccc(Cl)c1,Bioorg Med Chem Lett,CHEMBL565075,0.39811,Yes,6.399996913
CHEMBL1059865,Displacement of [3H]dofetilide from human ERG channel by scintillation proximity assay,O=C1N(CCN2C[C@@H]3CC[C@H]2Cc2ccccc2C3)CCN1c1cccc(Cl)c1,Bioorg Med Chem Lett,CHEMBL562464,0.0631,Yes,7.199970641
CHEMBL1059865,Displacement of [3H]dofetilide from human ERG channel by scintillation proximity assay,COc1cccc(C2CCCN(CCN3CCN(c4cccc(Cl)c4)C3=O)C2)c1,Bioorg Med Chem Lett,CHEMBL556496,0.19953,Yes,6.699991797
CHEMBL1059865,Displacement of [3H]dofetilide from human ERG channel by scintillation proximity assay,O=C1N(CCN2CCCC(OCc3ccccc3)C2)CCN1c1cccc(Cl)c1,Bioorg Med Chem Lett,CHEMBL557110,0.07943,Yes,7.100015437
CHEMBL1059865,Displacement of [3H]dofetilide from human ERG channel by scintillation proximity assay,O=C1N(CCN2CCC(c3ccc(Cl)cc3)CC2)CCN1c1cccc(Cl)c1,Bioorg Med Chem Lett,CHEMBL561128,0.007943,Yes,8.100015437
CHEMBL1059865,Displacement of [3H]dofetilide from human ERG channel by scintillation proximity assay,COc1cccc(CCN(C)CCN2CCN(c3cccc(Cl)c3)C2=O)c1,Bioorg Med Chem Lett,CHEMBL563926,0.63096,Yes,6.199998172
CHEMBL1059865,Displacement of [3H]dofetilide from human ERG channel by scintillation proximity assay,O=C1N(CCN2CCC(c3nnc(-c4ccccc4)o3)CC2)CCN1c1cccc(Cl)c1,Bioorg Med Chem Lett,CHEMBL561326,0.25119,Yes,6.599997654
CHEMBL1059865,Displacement of [3H]dofetilide from human ERG channel by scintillation proximity assay,Cc1cc(CN(C)CCN2CCN(c3cccc(Cl)c3)C2=O)on1,Bioorg Med Chem Lett,CHEMBL549438,50.11872,No,4.300000029
CHEMBL1059865,Displacement of [3H]dofetilide from human ERG channel by scintillation proximity assay,O=C1N(CCN2CCCc3sccc3C2)CCN1c1cccc(Cl)c1,Bioorg Med Chem Lett,CHEMBL559873,0.79433,Yes,6.099999035
CHEMBL1059865,Displacement of [3H]dofetilide from human ERG channel by scintillation proximity assay,CC1(C)[C@@H]2CC[C@]13CCN(CCN1CCN(c4cccc(Cl)c4)C1=O)C3C2,Bioorg Med Chem Lett,CHEMBL562833,0.79433,Yes,6.099999035
CHEMBL1062483,Displacement of [3H]dofetilide from human ERG,O=C(c1ccccc1Oc1ccccc1)N(CC1CCC1)[C@H]1CCNC1,Bioorg Med Chem Lett,CHEMBL549584,0.76,Yes,6.119186408
CHEMBL1061741,Inhibition of human ERG expressed in CHO cells by patch-clamp assay,O=C(COc1cccc(Cl)c1)NC1CCN(Cc2ccn(-c3ccc(C(F)(F)F)cc3)c2)CC1,Bioorg Med Chem Lett,CHEMBL472363,0.56,Yes,6.251811973
CHEMBL1060930,Inhibition of human ERG channel expressed in HEK293 cells by patch clamp assay,CN(CC1CCOCC1)C1CCN(c2nc3ccccc3n2Cc2ccc(F)cc2)CC1,Bioorg Med Chem Lett,CHEMBL550818,0.029,Yes,7.537602002
CHEMBL1060930,Inhibition of human ERG channel expressed in HEK293 cells by patch clamp assay,Cc1cnn(C2CCN(c3nc4ccccc4n3Cc3ccc(F)cc3)CC2)c1,Bioorg Med Chem Lett,CHEMBL556450,0.809,Yes,6.092051478
CHEMBL1060930,Inhibition of human ERG channel expressed in HEK293 cells by patch clamp assay,CN(c1nccc(=O)[nH]1)C1CCN(c2nc3ccccc3n2Cc2ccc(F)cc2)CC1,Bioorg Med Chem Lett,CHEMBL94454,0.441,Yes,6.355561411
CHEMBL1062741,Inhibition of human ERG by whole cell patch clamp assay,CN1CC[C@@H](N(Cc2ccccc2C(F)(F)F)c2ccc(C#N)c(Cl)c2)C1,Bioorg Med Chem Lett,CHEMBL563341,0.78,Yes,6.107905397
CHEMBL1042376,Inhibition of human ERG by patch-clamp assay,CC[C@H]1OC(=O)[C@H](C)C(=O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(OC)C[C@@H](C)C(=O)[C@H](C)[C@H]2N(CCCCn3cnc(-c4cccnc4)c3)C(=O)O[C@]12C,J Med Chem,CHEMBL1136,40,No,4.397940009
CHEMBL1042376,Inhibition of human ERG by patch-clamp assay,CC[C@H]1OC(=O)[C@H](C)C(=O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)C(=O)[C@H](C)[C@H]2N(C3CN(Cc4ccnc5cccnc45)C3)C(=O)O[C@]12C,J Med Chem,CHEMBL583090,196,No,3.707743929
CHEMBL1042376,Inhibition of human ERG by patch-clamp assay,CC[C@H]1OC(=O)[C@H](C)C(=O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)C(=O)[C@H](C)[C@H]2N(C3CN(Cc4ccnc5ncccc45)C3)C(=O)O[C@]12C,J Med Chem,CHEMBL583091,80,No,4.096910013
CHEMBL1042376,Inhibition of human ERG by patch-clamp assay,CC[C@H]1OC(=O)[C@H](C)C(=O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)C(=O)[C@H](C)[C@H]2N(C3CN([C@H](C)c4ccnc5ncccc45)C3)C(=O)O[C@]12C,J Med Chem,CHEMBL583093,43,No,4.366531544
CHEMBL1042376,Inhibition of human ERG by patch-clamp assay,CC[C@H]1OC(=O)[C@H](C)C(=O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)C(=O)[C@H](C)[C@H]2N(C3CN(Cc4c(O)cnc5ncccc45)C3)C(=O)O[C@]12C,J Med Chem,CHEMBL583298,140,No,3.853871964
CHEMBL1042376,Inhibition of human ERG by patch-clamp assay,CC[C@H]1OC(=O)[C@H](C)C(=O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)C(=O)[C@H](C)[C@H]2N(C3CN(Cc4c(O)cnc5cccnc45)C3)C(=O)O[C@]12C,J Med Chem,CHEMBL583299,67,No,4.173925197
CHEMBL1054535,Inhibition of human ERG expressed in HEK cells,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)C(=O)[C@H](C)[C@@H](O)[C@]1(C)O,J Med Chem,CHEMBL532,0.039,Yes,7.408935393
CHEMBL1054535,Inhibition of human ERG expressed in HEK cells,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)[C@H](OCC(=O)NC)[C@H](C)[C@@H](O)[C@]1(C)O,J Med Chem,CHEMBL572996,0.411,Yes,6.386158178
CHEMBL1054535,Inhibition of human ERG expressed in HEK cells,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)[C@H](O)[C@H](C)[C@@H](O)[C@]1(C)O,J Med Chem,CHEMBL584549,0.01,Yes,8
CHEMBL1052905,Inhibition of human ERG,CCOC(=O)CCc1ccc(OC[C@H](O)CNC(C)(C)Cc2ccc3ccccc3c2)c(C#N)c1.Cl,J Med Chem,CHEMBL1204009,0.0017,Yes,8.769551079
CHEMBL1052905,Inhibition of human ERG,CC(C)(Cc1ccc2ccccc2c1)NC[C@@H](O)COc1cccc(Cl)c1C#N,J Med Chem,CHEMBL180672,0.003,Yes,8.522878745
CHEMBL1052905,Inhibition of human ERG,CC(C)(Cc1ccc2ccccc2c1)NC[C@@H](O)COc1ccccc1C#N,J Med Chem,CHEMBL382741,0.0032,Yes,8.494850022
CHEMBL1052905,Inhibition of human ERG,COc1ccc(CC(C)(C)NC[C@H](O)COc2cccc3[nH]c(=O)[nH]c23)cc1,J Med Chem,CHEMBL486278,0.0118,Yes,7.928117993
CHEMBL1052905,Inhibition of human ERG,CC(C)(Cc1ccc2ccccc2c1)NC[C@@H](O)COc1ccc(CCC(=O)O)cc1C#N,J Med Chem,CHEMBL570593,0.0327,Yes,7.485452247
CHEMBL1052905,Inhibition of human ERG,CC(C)(Cc1ccc2ccccc2c1)NC[C@@H](O)COc1ccc(CCC(=O)O)cc1,J Med Chem,CHEMBL572163,0.0385,Yes,7.41453927
CHEMBL1045843,Inhibition of wild type human ERG expressed in CHOK1 cells by whole-cell plate-based electrophysiology,O=C(c1ccc(Cl)cc1)N1CCC2(CCN(Cc3cccc(Oc4ccccc4)c3)CC2)CC1,J Med Chem,CHEMBL429436,0.60256,Yes,6.219999702
CHEMBL1045843,Inhibition of wild type human ERG expressed in CHOK1 cells by whole-cell plate-based electrophysiology,O=C(c1ccc(Cl)cc1)N1CCC2(CCN(Cc3ccccc3Oc3ccccc3)CC2)CC1,J Med Chem,CHEMBL259243,0.08318,Yes,7.079981084
CHEMBL1045843,Inhibition of wild type human ERG expressed in CHOK1 cells by whole-cell plate-based electrophysiology,COc1ccccc1Oc1ccccc1CN1CCC2(CC1)CCN(C(=O)c1ccc(Cl)cc1)CC2,J Med Chem,CHEMBL409224,0.0871,Yes,7.059981845
CHEMBL1045843,Inhibition of wild type human ERG expressed in CHOK1 cells by whole-cell plate-based electrophysiology,COc1ccccc1Oc1ccccc1CN1CCC2(CC1)CCN(C(=O)c1ccncc1)CC2,J Med Chem,CHEMBL271128,0.04571,Yes,7.339988779
CHEMBL1045843,Inhibition of wild type human ERG expressed in CHOK1 cells by whole-cell plate-based electrophysiology,COc1ccccc1Oc1ccccc1CN1CCC2(CC1)CCN(C(=O)c1cc[n+]([O-])cc1)CC2,J Med Chem,CHEMBL270971,0.21878,Yes,6.659992382
CHEMBL1045843,Inhibition of wild type human ERG expressed in CHOK1 cells by whole-cell plate-based electrophysiology,COc1ccccc1Oc1ccccc1CN1CCC2(CC1)CCN(C(=O)c1ccncn1)CC2,J Med Chem,CHEMBL573216,0.07079,Yes,7.150028088
CHEMBL1045843,Inhibition of wild type human ERG expressed in CHOK1 cells by whole-cell plate-based electrophysiology,O=C(c1ccncc1)N1CCC2(CCN(Cc3cccc(Oc4ccccc4)c3)CC2)CC1,J Med Chem,CHEMBL271801,0.44668,Yes,6.350003493
CHEMBL1045843,Inhibition of wild type human ERG expressed in CHOK1 cells by whole-cell plate-based electrophysiology,O=C(c1ccncn1)N1CCC2(CCN(Cc3ccccc3Oc3ccccc3)CC2)CC1,J Med Chem,CHEMBL566974,0.22909,Yes,6.639993868
CHEMBL1045843,Inhibition of wild type human ERG expressed in CHOK1 cells by whole-cell plate-based electrophysiology,CC1(C)C=Cc2cccc(CN3CCC4(CC3)CCN(C(=O)c3ccnc(N)c3)CC4)c2O1,J Med Chem,CHEMBL568522,38.01894,No,4.419999996
CHEMBL1045843,Inhibition of wild type human ERG expressed in CHOK1 cells by whole-cell plate-based electrophysiology,CC1(C)Cc2cccc(CN3CCC4(CC3)CCN(C(=O)c3ccc(N)cn3)CC4)c2O1,J Med Chem,CHEMBL568523,43.65158,No,4.360000032
CHEMBL1045843,Inhibition of wild type human ERG expressed in CHOK1 cells by whole-cell plate-based electrophysiology,CC1(C)Oc2c(CN3CCC4(CC3)CCN(C(=O)c3ccc(N)cn3)CC4)cccc2C1(F)F,J Med Chem,CHEMBL579072,30.90295,No,4.510000061
CHEMBL1039568,Inhibition of human ERG by patch-clamp technique,COCCOc1ccc(C2CN(NS(C)(=O)=O)C(=O)N2CCc2ccc(OC)cc2)cc1,J Med Chem,CHEMBL571953,33,No,4.48148606
CHEMBL1039568,Inhibition of human ERG by patch-clamp technique,COc1ccc(CCN2C(=O)N(NS(=O)(=O)CC#N)C[C@@H]2c2ccc(OC)cc2)cc1,J Med Chem,CHEMBL570815,33,No,4.48148606
CHEMBL1036929,Displacement of [3H]dofetilide from human recombinant ERG expressed in HEK293 cells by patch clamp method,O=C(c1ccc(Cl)cc1)N1CCC2(CCN(Cc3cccc(Oc4ccccc4)c3)CC2)CC1,J Med Chem,CHEMBL429436,0.08128,Yes,7.090016305
CHEMBL1036929,Displacement of [3H]dofetilide from human recombinant ERG expressed in HEK293 cells by patch clamp method,O=C(c1ccc(Cl)cc1)N1CCC2(CCN(Cc3ccccc3Oc3ccccc3)CC2)CC1,J Med Chem,CHEMBL259243,0.006457,Yes,8.189969214
CHEMBL1036929,Displacement of [3H]dofetilide from human recombinant ERG expressed in HEK293 cells by patch clamp method,COc1ccccc1Oc1ccccc1CN1CCC2(CC1)CCN(C(=O)c1ccc(Cl)cc1)CC2,J Med Chem,CHEMBL409224,0.002512,Yes,8.599980365
CHEMBL1036929,Displacement of [3H]dofetilide from human recombinant ERG expressed in HEK293 cells by patch clamp method,COc1ccccc1Oc1ccccc1CN1CCC2(CC1)CCN(C(=O)c1ccncc1)CC2,J Med Chem,CHEMBL271128,0.0302,Yes,7.519993057
CHEMBL1036929,Displacement of [3H]dofetilide from human recombinant ERG expressed in HEK293 cells by patch clamp method,COc1ccccc1Oc1ccccc1CN1CCC2(CC1)CCN(C(=O)c1cc[n+]([O-])cc1)CC2,J Med Chem,CHEMBL270971,0.20893,Yes,6.679999196
CHEMBL1036929,Displacement of [3H]dofetilide from human recombinant ERG expressed in HEK293 cells by patch clamp method,COc1ccccc1Oc1ccccc1CN1CCC2(CC1)CCN(C(=O)c1ccncn1)CC2,J Med Chem,CHEMBL573216,0.12023,Yes,6.919987153
CHEMBL1036929,Displacement of [3H]dofetilide from human recombinant ERG expressed in HEK293 cells by patch clamp method,O=C(c1ccncc1)N1CCC2(CCN(Cc3cccc(Oc4ccccc4)c3)CC2)CC1,J Med Chem,CHEMBL271801,0.36308,Yes,6.439997673
CHEMBL1036929,Displacement of [3H]dofetilide from human recombinant ERG expressed in HEK293 cells by patch clamp method,CC1(C)CCc2cc(CN3CCC4(CC3)CCN(C(=O)c3ccc(N)cn3)CC4)ccc2O1,J Med Chem,CHEMBL567202,32.35937,No,4.489999942
CHEMBL1036929,Displacement of [3H]dofetilide from human recombinant ERG expressed in HEK293 cells by patch clamp method,CC1(C)Cc2cccc(CN3CCC4(CC3)CCN(C(=O)c3ccc(N)cn3)CC4)c2O1,J Med Chem,CHEMBL568523,37.15352,No,4.430000034
CHEMBL1036929,Displacement of [3H]dofetilide from human recombinant ERG expressed in HEK293 cells by patch clamp method,CC1(C)Oc2cccc(CN3CCC4(CC3)CCN(C(=O)c3ccnc(N)c3)CC4)c2O1,J Med Chem,CHEMBL584087,0.75858,Yes,6.119998612
CHEMBL1036929,Displacement of [3H]dofetilide from human recombinant ERG expressed in HEK293 cells by patch clamp method,CC1(C)Cc2cccc(CN3CCC4(CC3)CCN(C(=O)c3ncccc3N)CC4)c2O1,J Med Chem,CHEMBL566324,32.35937,No,4.489999942
CHEMBL1036929,Displacement of [3H]dofetilide from human recombinant ERG expressed in HEK293 cells by patch clamp method,CC1(C)Cc2c(CN3CCC4(CC3)CCN(C(=O)c3ccncc3)CC4)cccc2O1,J Med Chem,CHEMBL583621,30.19952,No,4.51999996
CHEMBL1036929,Displacement of [3H]dofetilide from human recombinant ERG expressed in HEK293 cells by patch clamp method,CC(C)(C)C1(C)Cc2c(CN3CCC4(CC3)CCN(C(=O)c3ccc(N)cn3)CC4)cccc2O1,J Med Chem,CHEMBL568294,30.90295,No,4.510000061
CHEMBL1036929,Displacement of [3H]dofetilide from human recombinant ERG expressed in HEK293 cells by patch clamp method,CC1(C)Oc2c(CN3CCC4(CC3)CCN(C(=O)c3ccc(N)cn3)CC4)cccc2C1(F)F,J Med Chem,CHEMBL579072,47.86301,No,4.319999993
CHEMBL1048092,Inhibition of human ERG in L929 cells at 10 uM by whole cell patch-clamp assay,CC(C)(C)c1ccc(C(O)CCCN2CCC(C(O)(c3ccccc3)c3ccccc3)CC2)cc1,Bioorg Med Chem Lett,CHEMBL17157,0.312,Yes,6.505845406
CHEMBL1048092,Inhibition of human ERG in L929 cells at 10 uM by whole cell patch-clamp assay,Cc1ccc(CCCCN2CCC(C(O)(c3ccccc3)c3ccccc3)CC2)cc1,Bioorg Med Chem Lett,CHEMBL571389,0.396,Yes,6.402304814
CHEMBL1048091,Inhibition of human ERG in L929 cells by whole cell patch-clamp assay,CC(C)(C)c1ccc(C(O)CCCN2CCC(C(O)(c3ccccc3)c3ccccc3)CC2)cc1,Bioorg Med Chem Lett,CHEMBL17157,0.312,Yes,6.505845406
CHEMBL1048091,Inhibition of human ERG in L929 cells by whole cell patch-clamp assay,Cc1ccc(CCCCN2CCC(C(O)(c3ccccc3)c3ccccc3)CC2)cc1,Bioorg Med Chem Lett,CHEMBL571389,0.396,Yes,6.402304814
CHEMBL1044431,Displacement of [3H]dofetilide from human ERG,C[C@@]12CC(c3ccccc3)C[C@@H](C1)N(CCN1CCN(c3cccc(Cl)c3)C1=O)C2,Bioorg Med Chem Lett,CHEMBL551927,0.0631,Yes,7.199970641
CHEMBL1044431,Displacement of [3H]dofetilide from human ERG,O=C1N(CCN2C[C@H]3CC[C@H](CC3)C2)CCN1c1cccc(Cl)c1,Bioorg Med Chem Lett,CHEMBL565075,0.39811,Yes,6.399996913
CHEMBL1044431,Displacement of [3H]dofetilide from human ERG,O=C1N(CCN2C[C@@H]3CC[C@H]2Cc2ccccc2C3)CCN1c1cccc(Cl)c1,Bioorg Med Chem Lett,CHEMBL562464,0.0631,Yes,7.199970641
CHEMBL1044431,Displacement of [3H]dofetilide from human ERG,COc1cccc(C2CCCN(CCN3CCN(c4cccc(Cl)c4)C3=O)C2)c1,Bioorg Med Chem Lett,CHEMBL556496,0.19953,Yes,6.699991797
CHEMBL1044431,Displacement of [3H]dofetilide from human ERG,O=C1N(CCN2CCCC(OCc3ccccc3)C2)CCN1c1cccc(Cl)c1,Bioorg Med Chem Lett,CHEMBL557110,0.07943,Yes,7.100015437
CHEMBL1044431,Displacement of [3H]dofetilide from human ERG,O=C1N(CCN2CCC(c3ccc(Cl)cc3)CC2)CCN1c1cccc(Cl)c1,Bioorg Med Chem Lett,CHEMBL561128,0.007943,Yes,8.100015437
CHEMBL1044431,Displacement of [3H]dofetilide from human ERG,COc1cccc(CCN(C)CCN2CCN(c3cccc(Cl)c3)C2=O)c1,Bioorg Med Chem Lett,CHEMBL563926,0.63096,Yes,6.199998172
CHEMBL1044431,Displacement of [3H]dofetilide from human ERG,O=C1N(CCN2CCC(c3nnc(-c4ccccc4)o3)CC2)CCN1c1cccc(Cl)c1,Bioorg Med Chem Lett,CHEMBL561326,0.25119,Yes,6.599997654
CHEMBL1044431,Displacement of [3H]dofetilide from human ERG,Cc1cc(CN(C)CCN2CCN(c3cccc(Cl)c3)C2=O)on1,Bioorg Med Chem Lett,CHEMBL549438,50.11872,No,4.300000029
CHEMBL1044431,Displacement of [3H]dofetilide from human ERG,O=C1N(CCN2CCCc3sccc3C2)CCN1c1cccc(Cl)c1,Bioorg Med Chem Lett,CHEMBL559873,0.79433,Yes,6.099999035
CHEMBL1044431,Displacement of [3H]dofetilide from human ERG,CC1(C)[C@@H]2CC[C@]13CCN(CCN1CCN(c4cccc(Cl)c4)C1=O)C3C2,Bioorg Med Chem Lett,CHEMBL562833,0.79433,Yes,6.099999035
CHEMBL1039122,Displacement of [35S]MK-499 from human ERG expressed in HEK293 cells,Fc1cc2c(cn1)C1(CCN(Cc3ccc(Oc4ccc(F)c(F)c4)cc3)CC1)OC2,Bioorg Med Chem Lett,CHEMBL593521,0.024,Yes,7.619788758
CHEMBL1039122,Displacement of [35S]MK-499 from human ERG expressed in HEK293 cells,Fc1cc2c(cn1)C1(CCN(Cc3ccc(Nc4ccc(F)c(F)c4)cc3)CC1)OC2,Bioorg Med Chem Lett,CHEMBL585509,0.023,Yes,7.638272164
CHEMBL1039122,Displacement of [35S]MK-499 from human ERG expressed in HEK293 cells,CN(c1ccc(CN2CCC3(CC2)OCc2cc(F)ncc23)cc1)c1ccc(F)c(F)c1,Bioorg Med Chem Lett,CHEMBL585856,0.025,Yes,7.602059991
CHEMBL1039122,Displacement of [35S]MK-499 from human ERG expressed in HEK293 cells,OC(c1ccc(CN2CCC3(CC2)OCc2cc(F)ncc23)cc1)c1ccc(F)c(F)c1,Bioorg Med Chem Lett,CHEMBL568572,0.52,Yes,6.283996656
CHEMBL1039122,Displacement of [35S]MK-499 from human ERG expressed in HEK293 cells,CC(O)(c1ccc(CN2CCC3(CC2)OCc2cc(F)ncc23)cc1)c1ccc(F)c(F)c1,Bioorg Med Chem Lett,CHEMBL568361,0.53,Yes,6.27572413
CHEMBL1039122,Displacement of [35S]MK-499 from human ERG expressed in HEK293 cells,O=C(c1ccc(CN2CCC3(CC2)OCc2cc(F)ncc23)cc1)c1ccc(F)c(F)c1,Bioorg Med Chem Lett,CHEMBL566257,0.017,Yes,7.769551079
CHEMBL1039122,Displacement of [35S]MK-499 from human ERG expressed in HEK293 cells,O/N=C(/c1ccc(CN2CCC3(CC2)OCc2cc(F)ncc23)cc1)c1ccc(F)c(F)c1,Bioorg Med Chem Lett,CHEMBL582978,0.31,Yes,6.508638306
CHEMBL1039122,Displacement of [35S]MK-499 from human ERG expressed in HEK293 cells,O/N=C(\c1ccc(CN2CCC3(CC2)OCc2cc(F)ncc23)cc1)c1ccc(F)c(F)c1,Bioorg Med Chem Lett,CHEMBL565614,0.28,Yes,6.552841969
CHEMBL1039122,Displacement of [35S]MK-499 from human ERG expressed in HEK293 cells,CO/N=C(/c1ccc(CN2CCC3(CC2)OCc2cc(F)ncc23)cc1)c1ccc(F)c(F)c1,Bioorg Med Chem Lett,CHEMBL566880,0.25,Yes,6.602059991
CHEMBL1039122,Displacement of [35S]MK-499 from human ERG expressed in HEK293 cells,CCO/N=C(/c1ccc(CN2CCC3(CC2)OCc2cc(F)ncc23)cc1)c1ccc(F)c(F)c1,Bioorg Med Chem Lett,CHEMBL568571,0.14,Yes,6.853871964
CHEMBL1039906,Displacement of [3H]dofetilide from human ERG expressed in HEK293 cells,CCc1n[nH]c(CC)c1Oc1cc(Cl)cc(C#N)c1,Bioorg Med Chem Lett,CHEMBL567916,39,No,4.408935393
CHEMBL1039906,Displacement of [3H]dofetilide from human ERG expressed in HEK293 cells,CCc1n[nH]c(CC)c1Oc1cc(C)cc(C#N)c1,Bioorg Med Chem Lett,CHEMBL576256,100,No,4
CHEMBL1070001,Inhibition of human ERG channel,FC(F)(F)c1cc(Nc2ccccc2)nc(NCc2ccccn2)n1,Bioorg Med Chem Lett,CHEMBL594979,40.1,No,4.396855627
CHEMBL1070001,Inhibition of human ERG channel,FC(F)(F)c1cc(Nc2ccncc2)nc(NCc2ccc3c(c2)OCO3)n1,Bioorg Med Chem Lett,CHEMBL607259,135,No,3.869666232
CHEMBL1072651,Inhibition of human ERG by patch clamp technique,CN1CC[C@H](N(Cc2ccccc2C(F)(F)F)c2ccc(C#N)c(Cl)c2)C1,Bioorg Med Chem Lett,CHEMBL558664,0.78,Yes,6.107905397
CHEMBL1069497,Inhibition of human ERG,Cc1ccc2oc(N3CCN4CCC3CC4)nc2n1,J Med Chem,CHEMBL604798,40,No,4.397940009
CHEMBL1074124,Inhibition of human ERG by patch clamp study,Cl.Cl.Cl.Cn1cnc(C(=O)N(Cc2cccc(Cl)c2)[C@H]2CC[C@@H](N)CC2)c1,Bioorg Med Chem Lett,CHEMBL3217125,65.6,No,4.183096161
CHEMBL1065722,Inhibition of human ERG,COC1(c2ccc(NC(=O)c3cc(=O)c4cc(F)cc(-c5c(C)nn(C)c5C)c4o3)cn2)CCOCC1,J Med Chem,CHEMBL605785,95,No,4.022276395
CHEMBL1073649,Inhibition of human ERG by patch-clamp method,CCCOCCn1c(=O)c(N2CCN([C@@H](C)[C@@H](C)O)CC2)nc2cnc(-c3ccc(OC)nc3)cc21,J Med Chem,CHEMBL589069,0.054,Yes,7.26760624
CHEMBL1073649,Inhibition of human ERG by patch-clamp method,CCCOCCn1c(=O)c(N2CCN(C[C@@H](C)O)CC2)nc2cnc(-c3ccc(OC)nc3)cc21,J Med Chem,CHEMBL590036,0.23,Yes,6.638272164
CHEMBL1073649,Inhibition of human ERG by patch-clamp method,CCCOCCn1c(=O)c(N2CCN(CC)CC2)nc2cnc(-c3ccc(OC)nc3)cc21,J Med Chem,CHEMBL590280,0.32,Yes,6.494850022
CHEMBL1073649,Inhibition of human ERG by patch-clamp method,CCCOCCn1c(=O)c(N2CCNCC2)nc2cnc(-c3ccc(OC)nc3)cc21,J Med Chem,CHEMBL591477,0.67,Yes,6.173925197
CHEMBL1101904,Displacement of [3H]dofetilide from human ERG expressed in HEK293 cells,N#Cc1nc(CCCN2CCCCC2)cc(-c2cccc(C(F)(F)F)c2)n1,Bioorg Med Chem Lett,CHEMBL1084400,0.16,Yes,6.795880017
CHEMBL1101904,Displacement of [3H]dofetilide from human ERG expressed in HEK293 cells,CCC(CC)NCCCc1cc(-c2cccc(C(F)(F)F)c2)nc(C#N)n1,Bioorg Med Chem Lett,CHEMBL1084401,0.32,Yes,6.494850022
CHEMBL1107671,Displacement of [3H]dofetidile from human ERG by scintillation proximity assay,Cc1ccc(C23CC2CN(CCCSc2nnc(-c4ocnc4C)n2C)C3)c(F)c1,J Med Chem,CHEMBL1081869,39.81072,No,4.399999968
CHEMBL1107671,Displacement of [3H]dofetidile from human ERG by scintillation proximity assay,Cc1ccc2c(-c3nnc(SCCCN4CC5CC5(c5ccccc5)C4)n3C)cccc2n1,J Med Chem,CHEMBL1081203,0.79433,Yes,6.099999035
CHEMBL1107671,Displacement of [3H]dofetidile from human ERG by scintillation proximity assay,Cc1ccc(-c2nnc(SCCCN3C[C@@H]4C[C@]4(c4ccc(C(F)(F)F)cc4)C3)n2C)cn1,J Med Chem,CHEMBL1079640,0.79433,Yes,6.099999035
CHEMBL1107671,Displacement of [3H]dofetidile from human ERG by scintillation proximity assay,Cc1cnc(-c2nnc(SCCCN3C[C@@H]4C[C@]4(c4ccc(C(F)(F)F)cc4)C3)n2C)cn1,J Med Chem,CHEMBL1079480,0.79433,Yes,6.099999035
CHEMBL1107671,Displacement of [3H]dofetidile from human ERG by scintillation proximity assay,Cc1ncoc1-c1nnc(SCCCN2C[C@@H]3C[C@]3(c3ccc(C(F)(F)F)cc3)C2)n1C,J Med Chem,CHEMBL1081409,0.79433,Yes,6.099999035
CHEMBL1107671,Displacement of [3H]dofetidile from human ERG by scintillation proximity assay,Cc1ncoc1-c1nnc(SCCCN2CC3CC3(c3ccc(Br)cc3)C2)n1C,J Med Chem,CHEMBL1082106,0.79433,Yes,6.099999035
CHEMBL1107671,Displacement of [3H]dofetidile from human ERG by scintillation proximity assay,Cc1ncoc1-c1nnc(SCCCN2CC3CC3(c3ccc(Cl)cc3)C2)n1C,J Med Chem,CHEMBL1080490,0.79433,Yes,6.099999035
CHEMBL1107671,Displacement of [3H]dofetidile from human ERG by scintillation proximity assay,Cc1ncoc1-c1nnc(SCCCN2CC3CC3(c3ccc(Cl)cc3)C2)n1C,J Med Chem,CHEMBL1080490,0.79433,Yes,6.099999035
CHEMBL1107671,Displacement of [3H]dofetidile from human ERG by scintillation proximity assay,Cc1ncoc1-c1nnc(SCCCN2CC3CC3(c3ccc(C(F)(F)F)cc3F)C2)n1C,J Med Chem,CHEMBL1081023,0.79433,Yes,6.099999035
CHEMBL1107671,Displacement of [3H]dofetidile from human ERG by scintillation proximity assay,COc1ccc(C23CC2CN(CCCSc2nnc(-c4ocnc4C)n2C)C3)cc1Cl,J Med Chem,CHEMBL1079494,0.79433,Yes,6.099999035
CHEMBL1107671,Displacement of [3H]dofetidile from human ERG by scintillation proximity assay,Cc1ccc2c(-c3nnc(SCCCN4CC5CC5(c5ccc(Cl)c(Cl)c5)C4)n3C)cccc2n1,J Med Chem,CHEMBL1081237,0.63096,Yes,6.199998172
CHEMBL1107671,Displacement of [3H]dofetidile from human ERG by scintillation proximity assay,Cc1ccc2c(-c3nnc(SCCCN4CC5CC5(c5ccc(C#N)cc5)C4)n3C)cccc2n1,J Med Chem,CHEMBL1079577,0.63096,Yes,6.199998172
CHEMBL1107671,Displacement of [3H]dofetidile from human ERG by scintillation proximity assay,COc1ccc(C23CC2CN(CCCSc2nnc(-c4cccc5nc(C)ccc45)n2C)C3)cc1,J Med Chem,CHEMBL1079578,0.63096,Yes,6.199998172
CHEMBL1107671,Displacement of [3H]dofetidile from human ERG by scintillation proximity assay,COc1ccc(C23CC2CN(CCCSc2nnc(-c4cccc5nc(C)ccc45)n2C)C3)cc1,J Med Chem,CHEMBL1079578,0.63096,Yes,6.199998172
CHEMBL1107671,Displacement of [3H]dofetidile from human ERG by scintillation proximity assay,Cn1c(SCCCN2C[C@@H]3C[C@]3(c3ccc(C(F)(F)F)cc3)C2)nnc1-c1ccccc1,J Med Chem,CHEMBL1081686,0.63096,Yes,6.199998172
CHEMBL1107671,Displacement of [3H]dofetidile from human ERG by scintillation proximity assay,Cc1ncoc1-c1nnc(SCCCN2C[C@H]3C[C@@]3(c3ccc(C(F)(F)F)cc3)C2)n1C,J Med Chem,CHEMBL1081580,0.63096,Yes,6.199998172
CHEMBL1107671,Displacement of [3H]dofetidile from human ERG by scintillation proximity assay,Cc1ncoc1-c1nnc(SCCCN2CC3CC3(c3ccc(C(C)(C)C)cc3)C2)n1C,J Med Chem,CHEMBL1079822,0.63096,Yes,6.199998172
CHEMBL1107671,Displacement of [3H]dofetidile from human ERG by scintillation proximity assay,Cc1ncoc1-c1nnc(SCCCN2CC3CC3(c3ccc(C(F)(F)F)c(F)c3)C2)n1C,J Med Chem,CHEMBL1080126,0.63096,Yes,6.199998172
CHEMBL1107671,Displacement of [3H]dofetidile from human ERG by scintillation proximity assay,Cc1ncoc1-c1nnc(SCCCN2CC3CC3(c3ccc(C(F)(F)F)c(F)c3)C2)n1C,J Med Chem,CHEMBL1080126,0.63096,Yes,6.199998172
CHEMBL1107671,Displacement of [3H]dofetidile from human ERG by scintillation proximity assay,Cc1ncoc1-c1nnc(SCCCN2CC3CC3(c3cccc(OC(F)(F)F)c3)C2)n1C,J Med Chem,CHEMBL1081934,0.63096,Yes,6.199998172
CHEMBL1107671,Displacement of [3H]dofetidile from human ERG by scintillation proximity assay,Cc1ccc2c(-c3nnc(SCCCN4C[C@H]5C[C@@]5(c5ccc(Br)cc5)C4)n3C)cccc2n1,J Med Chem,CHEMBL1080164,0.50119,Yes,6.299997603
CHEMBL1107671,Displacement of [3H]dofetidile from human ERG by scintillation proximity assay,Cc1ccc2c(-c3nnc(SCCCN4C[C@@H]5C[C@]5(c5ccc(C(F)(F)F)cc5)C4)n3C)cccc2n1,J Med Chem,CHEMBL1081685,0.50119,Yes,6.299997603
CHEMBL1107671,Displacement of [3H]dofetidile from human ERG by scintillation proximity assay,Cc1ncoc1-c1nnc(SCCCN2CC3CC3(c3ccc(Br)cc3)C2)n1C,J Med Chem,CHEMBL1082106,0.50119,Yes,6.299997603
CHEMBL1107671,Displacement of [3H]dofetidile from human ERG by scintillation proximity assay,Cc1ncoc1-c1nnc(SCCCN2CC3CC3(c3ccc(Cl)c(Cl)c3)C2)n1C,J Med Chem,CHEMBL1080846,0.50119,Yes,6.299997603
CHEMBL1107671,Displacement of [3H]dofetidile from human ERG by scintillation proximity assay,Cc1ncoc1-c1nnc(SCCCN2CC3CC3(c3ccc(C(F)(F)F)cc3F)C2)n1C,J Med Chem,CHEMBL1081023,0.50119,Yes,6.299997603
CHEMBL1107671,Displacement of [3H]dofetidile from human ERG by scintillation proximity assay,Cc1ncoc1-c1nnc(SCCCN2CC3CC3(c3ccc(F)c(C(F)(F)F)c3)C2)n1C,J Med Chem,CHEMBL1081587,0.50119,Yes,6.299997603
CHEMBL1107671,Displacement of [3H]dofetidile from human ERG by scintillation proximity assay,Cc1ncoc1-c1nnc(SCCCN2CC3CC3(c3ccc(Cl)cc3F)C2)n1C,J Med Chem,CHEMBL1081747,0.50119,Yes,6.299997603
CHEMBL1107671,Displacement of [3H]dofetidile from human ERG by scintillation proximity assay,Cc1ncoc1-c1nnc(SCCCN2C[C@H]3C[C@@]3(c3ccc(C(C)(C)C)cc3)C2)n1C,J Med Chem,CHEMBL1079823,0.39811,Yes,6.399996913
CHEMBL1107671,Displacement of [3H]dofetidile from human ERG by scintillation proximity assay,Cc1ncoc1-c1nnc(SCCCN2CC3CC3(c3ccc(Br)cc3)C2)n1C,J Med Chem,CHEMBL1082106,0.39811,Yes,6.399996913
CHEMBL1107671,Displacement of [3H]dofetidile from human ERG by scintillation proximity assay,Cc1ncoc1-c1nnc(SCCCN2CC3CC3(c3ccc(Cl)cc3)C2)n1C,J Med Chem,CHEMBL1080490,0.39811,Yes,6.399996913
CHEMBL1107671,Displacement of [3H]dofetidile from human ERG by scintillation proximity assay,Cc1cc(C(F)(F)F)ccc1C12CC1CN(CCCSc1nnc(-c3ocnc3C)n1C)C2,J Med Chem,CHEMBL1079814,0.39811,Yes,6.399996913
CHEMBL1107671,Displacement of [3H]dofetidile from human ERG by scintillation proximity assay,Cc1ncoc1-c1nnc(SCCCN2CC3CC3(c3ccc(C(F)(F)F)c(F)c3)C2)n1C,J Med Chem,CHEMBL1080126,0.39811,Yes,6.399996913
CHEMBL1107671,Displacement of [3H]dofetidile from human ERG by scintillation proximity assay,Cc1ncoc1-c1nnc(SCCCN2CC3CC3(c3ccc(Cl)cc3F)C2)n1C,J Med Chem,CHEMBL1081747,0.39811,Yes,6.399996913
CHEMBL1107671,Displacement of [3H]dofetidile from human ERG by scintillation proximity assay,Cc1ncoc1-c1nnc(SCCCN2CC3CC3(c3cccc(Cl)c3)C2)n1C,J Med Chem,CHEMBL1079461,0.31623,Yes,6.499996932
CHEMBL1107671,Displacement of [3H]dofetidile from human ERG by scintillation proximity assay,Cc1ncoc1-c1nnc(SCCCN2CC3CC3(c3ccc(F)cc3)C2)n1C,J Med Chem,CHEMBL1079462,0.31623,Yes,6.499996932
CHEMBL1107671,Displacement of [3H]dofetidile from human ERG by scintillation proximity assay,Cc1ncoc1-c1nnc(SCCCN2CC3CC3(c3ccc(OC(F)(F)F)cc3)C2)n1C,J Med Chem,CHEMBL1081966,0.31623,Yes,6.499996932
CHEMBL1107671,Displacement of [3H]dofetidile from human ERG by scintillation proximity assay,Cc1ccc2c(-c3nnc(SCCCN4CC5CC5(c5ccc(C(C)(C)C)cc5)C4)n3C)cccc2n1,J Med Chem,CHEMBL1081401,0.25119,Yes,6.599997654
CHEMBL1107671,Displacement of [3H]dofetidile from human ERG by scintillation proximity assay,Cc1ccc2c(-c3nnc(SCCCN4CC5CC5(c5ccc(C(C)(C)C)cc5)C4)n3C)cccc2n1,J Med Chem,CHEMBL1081401,0.25119,Yes,6.599997654
CHEMBL1107671,Displacement of [3H]dofetidile from human ERG by scintillation proximity assay,Cc1ccc2c(-c3nnc(SCCCN4CC5CC5(c5ccc(C(C)(C)C)cc5)C4)n3C)cccc2n1,J Med Chem,CHEMBL1081401,0.25119,Yes,6.599997654
CHEMBL1107671,Displacement of [3H]dofetidile from human ERG by scintillation proximity assay,Cc1ccc2c(-c3nnc(SCCCN4C[C@@H]5C[C@]5(c5ccc(Br)cc5)C4)n3C)cccc2n1,J Med Chem,CHEMBL1080165,0.25119,Yes,6.599997654
CHEMBL1107671,Displacement of [3H]dofetidile from human ERG by scintillation proximity assay,Cc1ncoc1-c1nnc(SCCCN2CC3CC3(c3ccc(OC(F)(F)F)cc3)C2)n1C,J Med Chem,CHEMBL1081966,0.25119,Yes,6.599997654
CHEMBL1107671,Displacement of [3H]dofetidile from human ERG by scintillation proximity assay,Cc1ccc2c(-c3nnc(SCCCN4CC5CC5(c5ccc(Cl)cc5)C4)n3C)cccc2n1,J Med Chem,CHEMBL1080117,0.19953,Yes,6.699991797
CHEMBL1107671,Displacement of [3H]dofetidile from human ERG by scintillation proximity assay,Cc1ccoc1-c1nnc(SCCCN2C[C@@H]3C[C@]3(c3ccc(C(F)(F)F)cc3)C2)n1C,J Med Chem,CHEMBL1079639,0.19953,Yes,6.699991797
CHEMBL1107671,Displacement of [3H]dofetidile from human ERG by scintillation proximity assay,Cc1ncoc1-c1nnc(SCCCN2CC3CC3(c3ccc(OC(F)(F)F)cc3)C2)n1C,J Med Chem,CHEMBL1081966,0.19953,Yes,6.699991797
CHEMBL1107671,Displacement of [3H]dofetidile from human ERG by scintillation proximity assay,Cc1ccc2c(-c3nnc(SCCCN4CC5CC5(c5ccc(C(F)(F)F)cc5)C4)n3C)cccc2n1,J Med Chem,CHEMBL1080293,0.15849,Yes,6.799998135
CHEMBL1107671,Displacement of [3H]dofetidile from human ERG by scintillation proximity assay,Cc1ccc2c(-c3nnc(SCCCN4CC5CC5(c5ccc(Br)cc5)C4)n3C)cccc2n1,J Med Chem,CHEMBL1079497,0.12589,Yes,6.900008766
CHEMBL1107673,Inhibition of human ERG by patch clamp electrophysiology assay,Cc1ncccc1-c1nnc(SCCCN2C[C@@H]3C[C@]3(c3ccc(C(F)(F)F)cc3)C2)n1C,J Med Chem,CHEMBL1081687,0.39,Yes,6.408935393
CHEMBL1107673,Inhibition of human ERG by patch clamp electrophysiology assay,Cn1c(SCCCN2C[C@@H]3C[C@]3(c3ccc(C(F)(F)F)cc3)C2)nnc1-c1ccnnc1,J Med Chem,CHEMBL1081867,0.47,Yes,6.327902142
CHEMBL1107673,Inhibition of human ERG by patch clamp electrophysiology assay,Cc1nc(C)c(-c2nnc(SCCCN3C[C@@H]4C[C@]4(c4ccc(C(F)(F)F)cc4)C3)n2C)s1,J Med Chem,CHEMBL1081746,0.35,Yes,6.455931956
CHEMBL1107673,Inhibition of human ERG by patch clamp electrophysiology assay,Cc1ncoc1-c1nnc(SCCCN2C[C@@H]3C[C@]3(c3ccc(C(F)(F)F)cc3)C2)n1C,J Med Chem,CHEMBL1081409,0.2,Yes,6.698970004
CHEMBL1107673,Inhibition of human ERG by patch clamp electrophysiology assay,Cc1ncoc1-c1nnc(SCCCN2CC3CC3(c3ccc(Cl)cc3)C2)n1C,J Med Chem,CHEMBL1080490,0.11,Yes,6.958607315
CHEMBL1107673,Inhibition of human ERG by patch clamp electrophysiology assay,Cc1ncoc1-c1nnc(SCCCN2CC3CC3(c3ccc(C(F)(F)F)cc3F)C2)n1C,J Med Chem,CHEMBL1081023,0.46,Yes,6.337242168
CHEMBL1113040,Inhibition of human ERG expressed in CHO cells by patch clamp technique,CCOc1cc(CN2CCC(Nc3nc4cc(S(=O)(=O)CC)ccc4o3)CC2)ccc1OC,Bioorg Med Chem Lett,CHEMBL1079313,0.18,Yes,6.744727495
CHEMBL1113040,Inhibition of human ERG expressed in CHO cells by patch clamp technique,CCOc1cc(CN2CCC(Nc3nc4cc(C(N)=O)ccc4o3)CC2)cc(OCC)c1F,Bioorg Med Chem Lett,CHEMBL1080584,0.43,Yes,6.366531544
CHEMBL1112305,Inhibition of human ERG,Cc1c(Cl)cccc1C(=O)N(CC(C)C)[C@H]1CCNC1,Bioorg Med Chem Lett,CHEMBL1078162,52.4,No,4.280668713
CHEMBL1107055,Inhibition of human ERG by patch clamp technique,CC(=O)N1CCC(c2[nH]nc(-c3ccc(F)cc3)c2-c2ccncc2)CC1,Bioorg Med Chem Lett,CHEMBL1092901,0.79,Yes,6.102372909
CHEMBL1108890,Inhibition of human ERG,CC(C)C(N1CCOCC1)C(O)(c1cccnc1)c1cccnc1,Bioorg Med Chem Lett,CHEMBL1091879,75,No,4.124938737
CHEMBL1108890,Inhibition of human ERG,CCCCC(N1CCOCC1)C(O)(c1cccnc1)c1cccnc1,Bioorg Med Chem Lett,CHEMBL1088803,36,No,4.443697499
CHEMBL1115186,Inhibition of human ERG by patch clamp assay,Cc1ccc2c(c1)CC(CCN(C)C)=C2Cc1cnccn1,Bioorg Med Chem Lett,CHEMBL1092600,0.52,Yes,6.283996656
CHEMBL1115186,Inhibition of human ERG by patch clamp assay,CN(C)CCC1=C(Cc2cnccn2)c2ccc(Cl)cc2C1,Bioorg Med Chem Lett,CHEMBL1092259,0.11,Yes,6.958607315
CHEMBL1115186,Inhibition of human ERG by patch clamp assay,CN(C)CCC1=C(Cc2cnccn2)c2ccc(F)cc2C1,Bioorg Med Chem Lett,CHEMBL1092649,0.59,Yes,6.229147988
CHEMBL1115186,Inhibition of human ERG by patch clamp assay,COc1nccnc1CC1=C(CCN(C)C)Cc2cc(Cl)ccc21,Bioorg Med Chem Lett,CHEMBL1092650,0.23,Yes,6.638272164
CHEMBL1115186,Inhibition of human ERG by patch clamp assay,CN(C)CCC1=C(Cc2cccnn2)c2ccc(F)cc2C1,Bioorg Med Chem Lett,CHEMBL1092662,0.89,Yes,6.050609993
CHEMBL1115186,Inhibition of human ERG by patch clamp assay,Cc1ccc2c(c1)CC(CCN(C)C)=C2[C@@H](C)c1cnccn1,Bioorg Med Chem Lett,CHEMBL1092663,0.36,Yes,6.443697499
CHEMBL1115186,Inhibition of human ERG by patch clamp assay,Cc1ccc2c(c1)CC(CCN(C)C)=C2[C@@H](C)c1nccs1,Bioorg Med Chem Lett,CHEMBL1090528,0.62,Yes,6.207608311
CHEMBL1115186,Inhibition of human ERG by patch clamp assay,CN(C)CCC1=C(Cc2cccnn2)c2ccc(Cl)cc2C1,Bioorg Med Chem Lett,CHEMBL1092652,0.22,Yes,6.657577319
CHEMBL1106982,Inhibition of human ERG expressed in HEK cells assessed as blockade of potassium tail current by standard patch clamp analysis,C[C@H](c1cccnc1)c1c(CCN(C)C)sc2ccccc12,Bioorg Med Chem Lett,CHEMBL1091777,0.49,Yes,6.30980392
CHEMBL1106982,Inhibition of human ERG expressed in HEK cells assessed as blockade of potassium tail current by standard patch clamp analysis,Cc1cccnc1[C@H](C)c1c(CCN(C)C)sc2ccccc12,Bioorg Med Chem Lett,CHEMBL1092126,0.91,Yes,6.040958608
CHEMBL1106982,Inhibition of human ERG expressed in HEK cells assessed as blockade of potassium tail current by standard patch clamp analysis,C[C@@H](c1ncccc1F)c1c(CCN(C)C)sc2ccccc12,Bioorg Med Chem Lett,CHEMBL1092377,0.33,Yes,6.48148606
CHEMBL1106982,Inhibition of human ERG expressed in HEK cells assessed as blockade of potassium tail current by standard patch clamp analysis,C[C@@H](c1ccc(F)cn1)c1c(CCN(C)C)sc2ccccc12,Bioorg Med Chem Lett,CHEMBL1092495,0.24,Yes,6.619788758
CHEMBL1107892,Inhibition of human ERG by ion works assay,O=C(NCc1cc(Cl)cc(Cl)c1)N(c1ccc(Br)cc1)C1CCN(C2CCCC2)CC1,Bioorg Med Chem Lett,CHEMBL1089681,0.061,Yes,7.214670165
CHEMBL1107892,Inhibition of human ERG by ion works assay,O=C(NCc1ccccc1)N(c1ccc(Br)cc1)C1CCN(C2CCCC2)CC1,Bioorg Med Chem Lett,CHEMBL1094028,0.178,Yes,6.749579998
CHEMBL1107892,Inhibition of human ERG by ion works assay,O=C(Nc1ccccc1)N(c1ccc(Br)cc1)C1CCN(C2CCCC2)CC1,Bioorg Med Chem Lett,CHEMBL1094029,0.188,Yes,6.725842151
CHEMBL1107892,Inhibition of human ERG by ion works assay,O=C(NCc1ccc(F)cc1)N(c1ccc(Br)cc1)C1CCN(C2CCCC2)CC1,Bioorg Med Chem Lett,CHEMBL1094030,0.202,Yes,6.694648631
CHEMBL1107892,Inhibition of human ERG by ion works assay,Nc1cc(CN2CCC(N(C(=O)NCc3ccc(F)cc3)c3ccc(Cl)cc3)CC2)ccn1,Bioorg Med Chem Lett,CHEMBL1091836,0.384,Yes,6.415668776
CHEMBL1104518,Inhibition of human ERG by electrophysiology assay,Cc1ccc(C(=O)NC2CC2)cc1-c1cc2cnn(-c3c(F)cccc3F)c2n(C)c1=O,J Med Chem,CHEMBL1089865,36,No,4.443697499
CHEMBL1110812,Inhibition of human ERG by electrophysiology assay,Cc1ccc(OC(=O)N(CC(=O)O)Cc2cccc(OCc3nc(-c4ccc(F)cc4)oc3C)c2)cc1,J Med Chem,CHEMBL1089164,38,No,4.420216403
CHEMBL1110812,Inhibition of human ERG by electrophysiology assay,Cc1ccc(OC(=O)N(CC(=O)O)Cc2cccc(OCc3nc(-c4ccc(C#N)cc4)oc3C)c2)cc1,J Med Chem,CHEMBL1090188,53,No,4.27572413
CHEMBL1110021,Inhibition of human ERG channel by patch clamp assay,CN1CCC[C@@H](c2nc3ccccc3n2Cc2ccc(F)cc2)C1,Bioorg Med Chem Lett,CHEMBL1095819,0.721,Yes,6.142064735
CHEMBL1110017,Inhibition of human ERG channel by electrophysiology assay,CCOCCn1c(N2CC[C@H](N(C)C)C2)nc2ccccc21,Bioorg Med Chem Lett,CHEMBL1087493,0.233,Yes,6.632644079
CHEMBL1110017,Inhibition of human ERG channel by electrophysiology assay,COc1ccc(Cn2c(N3CC[C@@H](N(C)C)C3)nc3ccccc32)cc1,Bioorg Med Chem Lett,CHEMBL1087367,0.492,Yes,6.308034897
CHEMBL1110017,Inhibition of human ERG channel by electrophysiology assay,Cc1cnn(C2CCN(c3nc4ccccc4n3Cc3ccc(F)cc3)CC2)c1,Bioorg Med Chem Lett,CHEMBL556450,0.809,Yes,6.092051478
CHEMBL1110017,Inhibition of human ERG channel by electrophysiology assay,CN(CC1CCOCC1)C1CCN(c2nc3ccccc3n2Cc2ccc(F)cc2)CC1,Bioorg Med Chem Lett,CHEMBL550818,0.029,Yes,7.537602002
CHEMBL1106514,Inhibition of human ERG expressed by patch clam electrophysiology assay,Cc1cccc(Nc2nc(N3CCNCC3)nc3c(C)nn(CCOCC(F)(F)F)c23)n1,Bioorg Med Chem Lett,CHEMBL1097718,0.56,Yes,6.251811973
CHEMBL1106514,Inhibition of human ERG expressed by patch clam electrophysiology assay,Cc1nn(CCOCC(F)(F)F)c2c(Nc3ccncn3)nc(N3CCN[C@H](C)C3)nc12,Bioorg Med Chem Lett,CHEMBL1098752,0.9,Yes,6.045757491
CHEMBL1105740,Displacement of [35S]MK499 from human ERG expressed in HEK293 cells,C[C@H](O)C(=O)NC1CC(C)(C)Oc2nc(-c3ccc(Cl)cc3Cl)c(-c3ccc(Cl)cc3)cc21,J Med Chem,CHEMBL1094521,0.12,Yes,6.920818754
CHEMBL1105740,Displacement of [35S]MK499 from human ERG expressed in HEK293 cells,CC1(C)CC(NC(=O)C(C)(C)O)c2cc(-c3ccc(Cl)cc3)c(-c3ccc(Cl)cc3Cl)nc2O1,J Med Chem,CHEMBL1094847,0.38,Yes,6.420216403
CHEMBL1105740,Displacement of [35S]MK499 from human ERG expressed in HEK293 cells,CC1(C)CC(NC(=O)C2(O)CC2)c2cc(-c3ccc(Cl)cc3)c(-c3ccc(Cl)cc3Cl)nc2O1,J Med Chem,CHEMBL1095499,0.3,Yes,6.522878745
CHEMBL1105740,Displacement of [35S]MK499 from human ERG expressed in HEK293 cells,Cc1cc(Cl)ccc1-c1nc2c(cc1-c1ccc(Cl)cc1)C(NC(=O)C(O)C(F)(F)F)CC(C)(C)O2,J Med Chem,CHEMBL1169572,0.26,Yes,6.585026652
CHEMBL1105740,Displacement of [35S]MK499 from human ERG expressed in HEK293 cells,Cc1cc(Cl)ccc1-c1nc2c(cc1-c1ccc(Cl)cc1)C(NC(=O)C(O)C(F)(F)F)CC(C)(C)O2,J Med Chem,CHEMBL1169572,0.41,Yes,6.387216143
CHEMBL1105740,Displacement of [35S]MK499 from human ERG expressed in HEK293 cells,CC1(C)CC(NC(=O)C(C)(O)C(F)(F)F)c2cc(-c3ccc(Cl)cc3)c(-c3ccc(Cl)cc3Cl)nc2O1,J Med Chem,CHEMBL1097455,0.6,Yes,6.22184875
CHEMBL1105740,Displacement of [35S]MK499 from human ERG expressed in HEK293 cells,CC1(C)CC(NC(=O)C(F)(F)CO)c2cc(-c3ccc(Cl)cc3)c(-c3ccc(Cl)cc3Cl)nc2O1,J Med Chem,CHEMBL1095159,0.08,Yes,7.096910013
CHEMBL1105740,Displacement of [35S]MK499 from human ERG expressed in HEK293 cells,CC1(C)C[C@@H](NC(=O)c2cn[nH]c2)c2cc(-c3ccc(Cl)cc3)c(-c3ccc(Cl)cc3Cl)nc2O1,J Med Chem,CHEMBL1097841,0.38,Yes,6.420216403
CHEMBL1105740,Displacement of [35S]MK499 from human ERG expressed in HEK293 cells,CC1(C)C[C@@H](NC(=O)c2ccc3[nH]ncc3c2)c2cc(-c3ccc(Cl)cc3)c(-c3ccc(Cl)cc3Cl)nc2O1,J Med Chem,CHEMBL1095554,0.63,Yes,6.200659451
CHEMBL1105740,Displacement of [35S]MK499 from human ERG expressed in HEK293 cells,CC(=O)N[C@@H]1CC(C)(C)Oc2nc(-c3ccc(Cl)cc3Cl)c(-c3ccc(Cl)cc3)cc21,J Med Chem,CHEMBL1095990,0.54,Yes,6.26760624
CHEMBL1105740,Displacement of [35S]MK499 from human ERG expressed in HEK293 cells,CS(=O)(=O)Nc1ccc2c(c1)[C@H](O)CC1(CCN([C@@H]3CCc4cc(C#N)ccc4C3)CC1)O2,J Med Chem,CHEMBL477015,0.67,Yes,6.173925197
CHEMBL1120514,Displacement of [3H]dofetilide from human ERG,COc1ccccc1CC(c1ccccc1)N1CCNCC1,Bioorg Med Chem Lett,CHEMBL214335,41,No,4.387216143
CHEMBL1120514,Displacement of [3H]dofetilide from human ERG,COc1ccccc1CC(c1ccccc1F)N1CCNCC1,Bioorg Med Chem Lett,CHEMBL1085959,40.1,No,4.396855627
CHEMBL1120514,Displacement of [3H]dofetilide from human ERG,COc1ccccc1CC(c1ccccc1)N1CCNCC1,Bioorg Med Chem Lett,CHEMBL214335,39,No,4.408935393
CHEMBL1120514,Displacement of [3H]dofetilide from human ERG,Fc1ccccc1C(Cc1ccccc1OC(F)(F)F)N1CCNCC1,Bioorg Med Chem Lett,CHEMBL1083426,0.76,Yes,6.119186408
CHEMBL1120225,Inhibition of human ERG,CC1(C)CC(NC(=O)CCO)c2cc(-c3ccc(Cl)cc3)c(-c3ccc(Cl)cc3Cl)nc2O1,Bioorg Med Chem Lett,CHEMBL1083025,0.38,Yes,6.420216403
CHEMBL1120225,Inhibition of human ERG,C[C@H](O)C(=O)NC1CC(C)(C)Oc2nc(-c3ccc(Cl)cc3Cl)c(-c3ccc(Cl)cc3)cc21,Bioorg Med Chem Lett,CHEMBL1094521,0.34,Yes,6.468521083
CHEMBL1120225,Inhibition of human ERG,CN1c2nc(-c3ccc(Cl)cc3Cl)c(-c3ccc(Cl)cc3)cc2C(C(=O)NCO)CC1(C)C,Bioorg Med Chem Lett,CHEMBL1082330,0.04,Yes,7.397940009
CHEMBL1120225,Inhibition of human ERG,C[C@@H](O)C(=O)NC1CC(C)(C)Oc2nc(-c3ccc(Cl)cc3Cl)c(-c3ccc(Cl)cc3)cc21,Bioorg Med Chem Lett,CHEMBL1083646,0.12,Yes,6.920818754
CHEMBL1119165,Inhibition of human ERG by patch clamp assay,Cn1nccc1-c1cc(NC(=O)c2cccc(C(F)(F)F)c2)ccc1OCCN1CCOCC1,J Med Chem,CHEMBL1086317,0.9,Yes,6.045757491
CHEMBL1175155,Displacement of [3H]astemizole from human ERG expressed in HEK293 cells,Cl.Nc1ncc(-c2cnn(C3CCNCC3)c2)cc1-c1nc2ccccc2o1,Bioorg Med Chem Lett,CHEMBL1170608,0.75,Yes,6.124938737
CHEMBL1175790,Inhibition of human ERG by patch clamp technique,O=C(c1ccc(Oc2ccc(F)cc2)cn1)N1CCCN(C2CCC2)CC1,Bioorg Med Chem Lett,CHEMBL1170953,0.9,Yes,6.045757491
CHEMBL1177037,Inhibition of human ERG expressed in CHO cells by patch clamp assay,CS(=O)(=O)c1ccc(OCC2CC2)c(C(=O)N2CCN(c3ccc(C#N)cc3F)CC2)c1,J Med Chem,CHEMBL497999,0.6,Yes,6.22184875
CHEMBL1177037,Inhibition of human ERG expressed in CHO cells by patch clamp assay,CC(C)COc1ccc(S(C)(=O)=O)cc1C(=O)N1CCN(c2ccc(C#N)cc2F)CC1,J Med Chem,CHEMBL1173634,0.7,Yes,6.15490196
CHEMBL1211615,Inhibition of human ERG,Cc1ncoc1-c1nnc(SCCCN2CC3CC3(c3ccc(S(F)(F)(F)(F)F)cc3)C2)n1C,Bioorg Med Chem Lett,CHEMBL1210552,0.50119,Yes,6.299997603
CHEMBL1211615,Inhibition of human ERG,Cc1ncoc1-c1nnc(SCCCN2CC3CC3(c3ccc(S(F)(F)(F)(F)F)cc3)C2)n1C,Bioorg Med Chem Lett,CHEMBL1210552,0.39811,Yes,6.399996913
CHEMBL1211615,Inhibition of human ERG,Cc1ncoc1-c1nnc(SCCCN2CC3CC3(c3ccc(S(F)(F)(F)(F)F)cc3)C2)n1C,Bioorg Med Chem Lett,CHEMBL1210552,0.79433,Yes,6.099999035
CHEMBL1217370,Displacement of [3H] astemizole from human recombinant ERG channel expressed in HEK293 cells,Cc1c(C(=O)NCCCN2CCN(c3cccc(Cl)c3Cl)CC2)cc(-c2ccccc2)n1C,Bioorg Med Chem,CHEMBL1086754,0.14,Yes,6.853871964
CHEMBL1217370,Displacement of [3H] astemizole from human recombinant ERG channel expressed in HEK293 cells,CCCn1c(-c2ccccc2)cc(C(=O)NCCCN2CCN(c3cccc(Cl)c3Cl)CC2)c1C,Bioorg Med Chem,CHEMBL1086756,0.54,Yes,6.26760624
CHEMBL1217370,Displacement of [3H] astemizole from human recombinant ERG channel expressed in HEK293 cells,CCCn1c(-c2ccccc2)cc(C(=O)N(C)CCCN2CCN(c3cccc(C)c3C)CC2)c1C,Bioorg Med Chem,CHEMBL1214176,0.7,Yes,6.15490196
CHEMBL1217370,Displacement of [3H] astemizole from human recombinant ERG channel expressed in HEK293 cells,Cc1c(C(=O)N(C)CCCN2CCN(c3cccc(Cl)c3Cl)CC2)cc(-c2ccccc2)n1C,Bioorg Med Chem,CHEMBL1214177,0.5,Yes,6.301029996
CHEMBL1217370,Displacement of [3H] astemizole from human recombinant ERG channel expressed in HEK293 cells,Cc1[nH]c(-c2ccccc2)cc1C(=O)NCCCN1CCN(c2cccc(Cl)c2Cl)CC1,Bioorg Med Chem,CHEMBL1086626,0.1,Yes,7
CHEMBL1217370,Displacement of [3H] astemizole from human recombinant ERG channel expressed in HEK293 cells,Cc1[nH]c(-c2ccccn2)cc1C(=O)NCCCN1CCN(c2cccc(Cl)c2Cl)CC1.Cl.Cl.Cl.Cl,Bioorg Med Chem,CHEMBL3217141,0.9,Yes,6.045757491
CHEMBL1219663,Displacement of [3H]dofetilide from human ERG at 10 uM,N#Cc1ccc(N2N=C(c3ccc4[nH]c(=O)oc4c3)C[C@@H]2c2ccc(F)cc2)cc1,J Med Chem,CHEMBL1215691,0.029,Yes,7.537602002
CHEMBL1219663,Displacement of [3H]dofetilide from human ERG at 10 uM,CN(C)CCN(C)C(=O)c1ccc(C2=NN(c3ccc(C#N)cc3)C(c3ccc(F)cc3)C2)cc1,J Med Chem,CHEMBL1215755,0.17,Yes,6.769551079
CHEMBL1225700,Inhibition of human ERG,C=CCN1C[C@H]2C[C@@]2(c2ccc(NS(=O)(=O)c3ccc(C(C)C)cc3)cc2)C1,Bioorg Med Chem Lett,CHEMBL1224698,0.1,Yes,7
CHEMBL1225700,Inhibition of human ERG,O=S(=O)(Nc1ccc([C@]23CNC[C@H]2C3)cc1)c1ccc(C(F)(F)F)cc1,Bioorg Med Chem Lett,CHEMBL1224700,0.79433,Yes,6.099999035
CHEMBL1225864,Inhibition of human ERG by electrophysiology assay,Cc1ccc(CN2[C@@H]3CC[C@H]2C[C@@H](Oc2cccc(C(N)=O)c2)C3)s1,Bioorg Med Chem Lett,CHEMBL1223815,0.26,Yes,6.585026652
CHEMBL1225864,Inhibition of human ERG by electrophysiology assay,NC(=O)c1cccc(O[C@H]2C[C@H]3CC[C@@H](C2)N3Cc2ccccc2)c1,Bioorg Med Chem Lett,CHEMBL1223873,0.61,Yes,6.214670165
CHEMBL1225864,Inhibition of human ERG by electrophysiology assay,NC(=O)c1cccc(C[C@@H]2C[C@H]3CC[C@@H](C2)N3Cc2ccccc2)c1,Bioorg Med Chem Lett,CHEMBL1223953,0.25,Yes,6.602059991
CHEMBL1225864,Inhibition of human ERG by electrophysiology assay,NC(=O)c1cc(F)cc(O[C@H]2C[C@H]3CC[C@@H](C2)N3Cc2ccccc2)c1,Bioorg Med Chem Lett,CHEMBL1224139,0.68,Yes,6.167491087
CHEMBL1225864,Inhibition of human ERG by electrophysiology assay,Cc1cc(O[C@H]2C[C@H]3CC[C@@H](C2)N3Cc2ccccc2)cc(C(N)=O)c1,Bioorg Med Chem Lett,CHEMBL1224140,0.66,Yes,6.180456064
CHEMBL1225864,Inhibition of human ERG by electrophysiology assay,NC(=O)c1ccccc1O[C@H]1C[C@H]2CC[C@@H](C1)N2Cc1ccccc1,Bioorg Med Chem Lett,CHEMBL1224213,0.34,Yes,6.468521083
CHEMBL1225864,Inhibition of human ERG by electrophysiology assay,NC(=O)c1ccc(O[C@H]2C[C@H]3CC[C@@H](C2)N3Cc2ccccc2)cc1,Bioorg Med Chem Lett,CHEMBL1224214,0.68,Yes,6.167491087
CHEMBL1247720,Inhibition of human ERG,C[C@H]1Cc2c([nH]c3cc(Cl)c(F)cc23)[C@@]2(N1)C(=O)Nc1ccc(Cl)cc12,Science,CHEMBL1082723,30.44,No,4.516555352
CHEMBL1259359,Inhibition of human ERG,NC(=O)c1cccc(O[C@@H]2C[C@H]3CC[C@@H](C2)N3Cc2ccccc2)c1,Bioorg Med Chem Lett,CHEMBL1223951,0.00061,Yes,9.214670165
CHEMBL1259359,Inhibition of human ERG,NC(=O)c1cccc(O[C@@H]2C[C@H]3CC[C@@H](C2)N3Cc2cccs2)c1,Bioorg Med Chem Lett,CHEMBL1257577,0.00043,Yes,9.366531544
CHEMBL1259359,Inhibition of human ERG,Cc1ccc(CN2[C@@H]3CC[C@H]2C[C@H](Oc2cccc(C(N)=O)c2)C3)s1,Bioorg Med Chem Lett,CHEMBL1257578,0.00026,Yes,9.585026652
CHEMBL1259359,Inhibition of human ERG,Cc1ccc(CN2[C@@H]3CC[C@H]2C[C@H](Oc2cccc(C(N)=O)c2)C3)o1,Bioorg Med Chem Lett,CHEMBL1255595,0.0028,Yes,8.552841969
CHEMBL1259359,Inhibition of human ERG,NC(=O)c1cccc(O[C@@H]2C[C@H]3CC[C@@H](C2)N3CCc2ccccc2)c1,Bioorg Med Chem Lett,CHEMBL1257698,0.00038,Yes,9.420216403
CHEMBL1259359,Inhibition of human ERG,NC(=O)c1cccc(O[C@@H]2C[C@H]3CC[C@@H](C2)N3CCCc2ccccc2)c1,Bioorg Med Chem Lett,CHEMBL1257820,0.00025,Yes,9.602059991
CHEMBL1259359,Inhibition of human ERG,Cc1ccc(CN2[C@@H]3CC[C@H]2C[C@H](Oc2cccc(C(N)=O)c2)C3)cc1,Bioorg Med Chem Lett,CHEMBL1257821,0.00014,Yes,9.853871964
CHEMBL1259359,Inhibition of human ERG,Cc1cccc(CN2[C@@H]3CC[C@H]2C[C@H](Oc2cccc(C(N)=O)c2)C3)c1,Bioorg Med Chem Lett,CHEMBL1257937,0.00052,Yes,9.283996656
CHEMBL1259359,Inhibition of human ERG,Cc1ccccc1CN1[C@@H]2CC[C@H]1C[C@H](Oc1cccc(C(N)=O)c1)C2,Bioorg Med Chem Lett,CHEMBL1257938,0.00062,Yes,9.207608311
CHEMBL1259359,Inhibition of human ERG,NC(=O)c1cccc(O[C@@H]2C[C@H]3CC[C@@H](C2)N3Cc2ccncc2)c1,Bioorg Med Chem Lett,CHEMBL1258047,0.0015,Yes,8.823908741
CHEMBL1259359,Inhibition of human ERG,NC(=O)c1cccc(O[C@@H]2C[C@H]3CC[C@@H](C2)N3Cc2cccnc2)c1,Bioorg Med Chem Lett,CHEMBL1258048,0.0035,Yes,8.455931956
CHEMBL1259359,Inhibition of human ERG,NC(=O)c1cccc(O[C@@H]2C[C@H]3CC[C@@H](C2)N3Cc2ccccn2)c1,Bioorg Med Chem Lett,CHEMBL1258164,0.0019,Yes,8.721246399
CHEMBL1259359,Inhibition of human ERG,NC(=O)c1cccc(O[C@@H]2C[C@H]3CC[C@@H](C2)N3CC2CC2)c1,Bioorg Med Chem Lett,CHEMBL1258166,0.0073,Yes,8.13667714
CHEMBL1259359,Inhibition of human ERG,NC(=O)c1cccc(O[C@@H]2C[C@H]3CC[C@@H](C2)N3CC2CCCCC2)c1,Bioorg Med Chem Lett,CHEMBL1258279,0.002,Yes,8.698970004
CHEMBL1259359,Inhibition of human ERG,NC(=O)c1cccc(O[C@@H]2C[C@H]3CC[C@@H](C2)N3Cc2ccc3c(c2)OCO3)c1,Bioorg Med Chem Lett,CHEMBL1258280,0.00062,Yes,9.207608311
CHEMBL1259359,Inhibition of human ERG,CS(=O)(=O)Cc1ccc(CN2[C@@H]3CC[C@H]2C[C@H](Oc2cccc(C(N)=O)c2)C3)cc1,Bioorg Med Chem Lett,CHEMBL1258391,0.0066,Yes,8.180456064
CHEMBL1259359,Inhibition of human ERG,NC(=O)c1cccc(O[C@@H]2C[C@H]3CC[C@@H](C2)N3CC(=O)Nc2ccccc2)c1,Bioorg Med Chem Lett,CHEMBL1258503,0.00072,Yes,9.142667504
CHEMBL1259359,Inhibition of human ERG,CC(c1ccccc1)N1[C@@H]2CC[C@H]1C[C@H](Oc1cccc(C(N)=O)c1)C2,Bioorg Med Chem Lett,CHEMBL1258615,0.006,Yes,8.22184875
CHEMBL1259359,Inhibition of human ERG,Cc1ccc(C(C)N2[C@@H]3CC[C@H]2C[C@H](Oc2cccc(C(N)=O)c2)C3)s1,Bioorg Med Chem Lett,CHEMBL1258616,0.0016,Yes,8.795880017
CHEMBL1259359,Inhibition of human ERG,Cc1ccccc1C(C)N1[C@@H]2CC[C@H]1C[C@H](Oc1cccc(C(N)=O)c1)C2,Bioorg Med Chem Lett,CHEMBL1258724,0.0049,Yes,8.30980392
CHEMBL1259359,Inhibition of human ERG,NC(=O)c1cccc(O[C@@H]2C[C@H]3CC[C@@H](C2)N3C2CCCc3ccccc32)c1,Bioorg Med Chem Lett,CHEMBL1258725,0.00095,Yes,9.022276395
CHEMBL1259359,Inhibition of human ERG,NC(=O)c1cccc(O[C@@H]2C[C@H]3CC[C@@H](C2)N3C2CCCCC2)c1,Bioorg Med Chem Lett,CHEMBL1258845,0.015,Yes,7.823908741
CHEMBL1259359,Inhibition of human ERG,CC(C)(c1ccccc1)N1[C@@H]2CC[C@H]1C[C@H](Oc1cccc(C(N)=O)c1)C2,Bioorg Med Chem Lett,CHEMBL1258846,0.0047,Yes,8.327902142
CHEMBL1259359,Inhibition of human ERG,NC(=O)c1cccc(O[C@@H]2C[C@H]3CC[C@@H](C2)N3C2(c3ccccc3)CC2)c1,Bioorg Med Chem Lett,CHEMBL1258961,0.0048,Yes,8.318758763
CHEMBL1259359,Inhibition of human ERG,CC(c1ccncc1)N1[C@@H]2CC[C@H]1C[C@H](Oc1cccc(C(N)=O)c1)C2,Bioorg Med Chem Lett,CHEMBL1258962,0.0037,Yes,8.431798276
CHEMBL1259359,Inhibition of human ERG,C[C@H](c1ccccc1)N1[C@@H]2CC[C@H]1C[C@H](Oc1cccc(C(N)=O)c1)C2,Bioorg Med Chem Lett,CHEMBL1257226,0.013,Yes,7.886056648
CHEMBL1259359,Inhibition of human ERG,C[C@@H](c1ccccc1)N1[C@@H]2CC[C@H]1C[C@H](Oc1cccc(C(N)=O)c1)C2,Bioorg Med Chem Lett,CHEMBL1257227,0.0018,Yes,8.744727495
CHEMBL1259359,Inhibition of human ERG,COc1cccc([C@@H](C)N2[C@@H]3CC[C@H]2C[C@H](Oc2cccc(C(N)=O)c2)C3)c1,Bioorg Med Chem Lett,CHEMBL1257348,0.0046,Yes,8.337242168
CHEMBL1259359,Inhibition of human ERG,Cc1ccc([C@@H](C)N2[C@@H]3CC[C@H]2C[C@H](Oc2cccc(C(N)=O)c2)C3)cn1,Bioorg Med Chem Lett,CHEMBL1257458,0.003,Yes,8.522878745
CHEMBL1259359,Inhibition of human ERG,C[C@H](c1ccnc(Cl)c1)N1[C@@H]2CC[C@H]1C[C@H](Oc1cccc(C(N)=O)c1)C2,Bioorg Med Chem Lett,CHEMBL1257459,0.013,Yes,7.886056648
CHEMBL1259359,Inhibition of human ERG,C[C@H](c1ccc(Cl)nc1)N1[C@@H]2CC[C@H]1C[C@H](Oc1cccc(C(N)=O)c1)C2,Bioorg Med Chem Lett,CHEMBL1257579,0.0033,Yes,8.48148606
CHEMBL1259359,Inhibition of human ERG,Cc1ccc([C@@H](C)N2[C@@H]3CC[C@H]2C[C@H](Oc2cccc(C(N)=O)c2)C3)s1,Bioorg Med Chem Lett,CHEMBL1257347,0.0028,Yes,8.552841969
CHEMBL1261450,Displacement of [3H]-dofetilide from human ERG by scintillation proximity assay,Cc1ncoc1-c1nnc(SCCCN2CCC3(c4ccc(C(F)(F)F)cc4)CC3C2)n1C,J Med Chem,CHEMBL1257686,0.79433,Yes,6.099999035
CHEMBL1261450,Displacement of [3H]-dofetilide from human ERG by scintillation proximity assay,Cc1ncoc1-c1nnc(SCCCN2CCC3(c4cccc(C(F)(F)F)c4)CC3C2)n1C,J Med Chem,CHEMBL1257808,0.19953,Yes,6.699991797
CHEMBL1261450,Displacement of [3H]-dofetilide from human ERG by scintillation proximity assay,Cc1nc(C)c(-c2nnc(SCCCN3CCC4CC4(c4ccc(C(F)(F)F)cc4)CC3)n2C)s1,J Med Chem,CHEMBL1257926,0.63096,Yes,6.199998172
CHEMBL1261450,Displacement of [3H]-dofetilide from human ERG by scintillation proximity assay,Cc1ncoc1-c1nnc(SCCCN[C@@H]2CC[C@]3(c4ccc(C(F)(F)F)cc4)CC23)n1C,J Med Chem,CHEMBL1258035,0.25119,Yes,6.599997654
CHEMBL1261450,Displacement of [3H]-dofetilide from human ERG by scintillation proximity assay,Cc1ncoc1-c1nnc(SCCCN[C@@H]2CC[C@]3(c4ccc(C(F)(F)F)cc4)CC23)n1C,J Med Chem,CHEMBL1258035,0.63096,Yes,6.199998172
CHEMBL1261450,Displacement of [3H]-dofetilide from human ERG by scintillation proximity assay,Cc1ncoc1-c1nnc(SCCCN[C@@H]2CC[C@]3(c4ccc(C(F)(F)F)cc4F)CC23)n1C,J Med Chem,CHEMBL1258268,0.63096,Yes,6.199998172
CHEMBL1261450,Displacement of [3H]-dofetilide from human ERG by scintillation proximity assay,Cc1ncoc1-c1nnc(SCCCN2CCC3(CCCc4cc(Br)ccc43)C2)n1C,J Med Chem,CHEMBL1258380,0.63096,Yes,6.199998172
CHEMBL1261450,Displacement of [3H]-dofetilide from human ERG by scintillation proximity assay,Cc1ncoc1-c1nnc(SCCCN2CCC3(CCc4cc(Br)ccc43)C2)n1C,J Med Chem,CHEMBL1258712,0.31623,Yes,6.499996932
CHEMBL1261450,Displacement of [3H]-dofetilide from human ERG by scintillation proximity assay,Cc1ncoc1-c1nnc(SCCCN2CCC3(CCc4c(Br)cccc43)C2)n1C,J Med Chem,CHEMBL1258713,0.63096,Yes,6.199998172
CHEMBL1261450,Displacement of [3H]-dofetilide from human ERG by scintillation proximity assay,Cc1ncoc1-c1nnc(SCCCN2CCC3(CCc4ccc(Br)cc43)C2)n1C,J Med Chem,CHEMBL1258833,0.79433,Yes,6.099999035
CHEMBL1261450,Displacement of [3H]-dofetilide from human ERG by scintillation proximity assay,Cc1ncoc1-c1nnc(SCCCN2[C@@H]3CC[C@H]2C[C@@H](c2ccc(C(F)(F)F)cc2)C3)n1C,J Med Chem,CHEMBL1257336,0.15849,Yes,6.799998135
CHEMBL1261450,Displacement of [3H]-dofetilide from human ERG by scintillation proximity assay,Cc1ncoc1-c1nnc(SCCCN2[C@@H]3CC[C@H]2C[C@@H](c2cccc(C(F)(F)F)c2)C3)n1C,J Med Chem,CHEMBL1257337,0.50119,Yes,6.299997603
CHEMBL1261450,Displacement of [3H]-dofetilide from human ERG by scintillation proximity assay,Cc1ncoc1-c1nnc(SCCCN2[C@@H]3CC[C@H]2C[C@@H](c2ccc(C(F)(F)F)cc2F)C3)n1C,J Med Chem,CHEMBL1257448,0.50119,Yes,6.299997603
CHEMBL1273164,Inhibition of human ERG,Cc1nc2ccccc2n1C1C[C@H]2CC[C@@H](C1)N2CC[C@H](NC(=O)C1CCSCC1)c1cccc(F)c1,Bioorg Med Chem Lett,CHEMBL1271606,0.74,Yes,6.13076828
CHEMBL1274536,Inhibition of human ERG expressed in HEK cells by patch clamp technique,COc1ccccc1-c1nc2c(C(=O)N[C@@H]3CN4CCC3CC4)cccc2o1,Bioorg Med Chem Lett,CHEMBL1272016,0.2,Yes,6.698970004
CHEMBL1274536,Inhibition of human ERG expressed in HEK cells by patch clamp technique,COc1ccccc1-c1nc2c(C(=O)N[C@@H]3C[C@H]4CCC[C@@H](C3)N4C)cccc2o1,Bioorg Med Chem Lett,CHEMBL3084777,0.4,Yes,6.397940009
CHEMBL1274536,Inhibition of human ERG expressed in HEK cells by patch clamp technique,O=C(N[C@@H]1CN2CCC1CC2)c1cccc2oc(C3CC3)nc12,Bioorg Med Chem Lett,CHEMBL1272072,0.7,Yes,6.15490196
CHEMBL1274536,Inhibition of human ERG expressed in HEK cells by patch clamp technique,CN1[C@@H]2CCC[C@H]1C[C@H](NC(=O)c1cccc3oc(C4CC4)nc13)C2,Bioorg Med Chem Lett,CHEMBL3084778,0.2,Yes,6.698970004
CHEMBL1274536,Inhibition of human ERG expressed in HEK cells by patch clamp technique,Cc1nccn1CC1CCc2c(c3ccccc3n2C)C1=O,Bioorg Med Chem Lett,CHEMBL46,0.4,Yes,6.397940009
CHEMBL1287098,Displacement of [3H]dofetilide from human ERG by scintillation proximity assay,O=C(O)CCNC1CC[C@]2(Cc3ccccc3Cc3ccccc32)C1,J Med Chem,CHEMBL1278114,63.09573,No,4.200000031
CHEMBL1292008,Displacement of [3H]-dofetilide from human ERG,N#Cc1ccc(CNC(=O)N(c2cccc(F)c2)C2CCN(CCC3(c4cccc(F)c4)CCN(C(=O)c4ccc(F)cc4O)CC3)CC2)cc1,Bioorg Med Chem Lett,CHEMBL1288675,0.8,Yes,6.096910013
CHEMBL1292008,Displacement of [3H]-dofetilide from human ERG,N#Cc1ccc(CNC(=O)N(c2cccc(F)c2)C2CCN(CCC3(c4cccc(F)c4)CCN(C(=O)c4ccc(C#N)cc4)CC3)CC2)cc1,Bioorg Med Chem Lett,CHEMBL1288676,0.4,Yes,6.397940009
CHEMBL1293077,Displacement of [3H]-dofetilide in human ERG expressed in CHO cells,Cc1ncccc1N1C[C@]2(CC[C@@H](c3nc4cc(OC(F)(F)F)ccc4[nH]3)CC2)OC1=O,Bioorg Med Chem Lett,CHEMBL1289610,50.11872,No,4.300000029
CHEMBL1293077,Displacement of [3H]-dofetilide in human ERG expressed in CHO cells,O=C1O[C@]2(CC[C@H](c3nc4cc(OC(F)(F)F)ccc4[nH]3)CC2)CN1c1ccc(F)cc1,Bioorg Med Chem Lett,CHEMBL1289386,0.79433,Yes,6.099999035
CHEMBL1291783,Displacement of [3H]-dofetilide from human hERG,CC(C)S(=O)(=O)N[C@H]1CN(C)C[C@@H]1c1ccc(-c2cccc(NS(C)(=O)=O)c2)cc1,Bioorg Med Chem Lett,CHEMBL1289960,31.6,No,4.500312917
CHEMBL1291783,Displacement of [3H]-dofetilide from human hERG,CCN1C[C@H](NS(=O)(=O)C(C)C)[C@@H](c2ccc(-c3ccc(C#N)cc3)cc2)C1,Bioorg Med Chem Lett,CHEMBL1290275,0.4,Yes,6.397940009
CHEMBL1291783,Displacement of [3H]-dofetilide from human hERG,CC(C)S(=O)(=O)N[C@H]1CN(c2ccccc2)C[C@@H]1c1ccc(-c2ccc(C#N)cc2)cc1,Bioorg Med Chem Lett,CHEMBL1290391,0.8,Yes,6.096910013
CHEMBL1291783,Displacement of [3H]-dofetilide from human hERG,CC(C)S(=O)(=O)N[C@H]1CN(C)C[C@@H]1c1ccc(-c2cccnc2)cc1,Bioorg Med Chem Lett,CHEMBL1290731,31.6,No,4.500312917
CHEMBL1291783,Displacement of [3H]-dofetilide from human hERG,CC(C)S(=O)(=O)N[C@H]1CN(c2ccccc2)C[C@@H]1c1ccc(-c2ccc(F)nc2)cc1,Bioorg Med Chem Lett,CHEMBL1289063,0.08,Yes,7.096910013
CHEMBL1292296,Inhibition of human ERG expressed in HEK cells by mini-patch clamp assay,COC[C@H]1CCCN1CCn1ncc2cc(-n3ccc(OCc4ccccc4)cc3=O)ccc21,Bioorg Med Chem Lett,CHEMBL1289054,0.8,Yes,6.096910013
CHEMBL1648352,Displacement of radiolabeled MK-499 from human ERG expressed in HEK293 cells,COc1cc(/C=C/c2nc3ccccc3[nH]2)ccc1-n1cnc(C)c1,Bioorg Med Chem Lett,CHEMBL1642173,0.68,Yes,6.167491087
CHEMBL1648352,Displacement of radiolabeled MK-499 from human ERG expressed in HEK293 cells,COc1cc(/C=C/c2nc3cc(C(F)(F)F)ccc3c(=O)[nH]2)ccc1-n1cnc(C)c1,Bioorg Med Chem Lett,CHEMBL1642180,0.87,Yes,6.060480747
CHEMBL1648352,Displacement of radiolabeled MK-499 from human ERG expressed in HEK293 cells,COc1cc(/C=C/c2nc(N)c3ccccc3n2)ccc1-n1cnc(C)c1,Bioorg Med Chem Lett,CHEMBL1642184,0.14,Yes,6.853871964
CHEMBL1648352,Displacement of radiolabeled MK-499 from human ERG expressed in HEK293 cells,COc1cc(/C=C/c2nc3ccccc3c(=O)n2-c2ccccc2)ccc1-n1cnc(C)c1,Bioorg Med Chem Lett,CHEMBL1642185,0.99,Yes,6.004364805
CHEMBL1648352,Displacement of radiolabeled MK-499 from human ERG expressed in HEK293 cells,COc1cc(/C=C/c2nc3ccccc3c(=O)n2C)ccc1-n1cnc(C)c1,Bioorg Med Chem Lett,CHEMBL1642186,0.31,Yes,6.508638306
CHEMBL1648352,Displacement of radiolabeled MK-499 from human ERG expressed in HEK293 cells,COc1cc(/C=C/c2nc(N)nc(Nc3ccccc3)n2)ccc1-n1cnc(C)c1,Bioorg Med Chem Lett,CHEMBL1642187,0.3,Yes,6.522878745
CHEMBL1648352,Displacement of radiolabeled MK-499 from human ERG expressed in HEK293 cells,CCOC(=O)c1sc2nc(/C=C/c3ccc(-n4cnc(C)c4)c(OC)c3)nc(N)c2c1C,Bioorg Med Chem Lett,CHEMBL1642188,0.98,Yes,6.008773924
CHEMBL1648352,Displacement of radiolabeled MK-499 from human ERG expressed in HEK293 cells,COc1cc(/C=C/c2nc(N)c3c(n2)oc2ccccc23)ccc1-n1cnc(C)c1,Bioorg Med Chem Lett,CHEMBL1642189,0.51,Yes,6.292429824
CHEMBL1648352,Displacement of radiolabeled MK-499 from human ERG expressed in HEK293 cells,COc1cc(/C=C/c2nc(N)c3c4c(sc3n2)CCCCC4)ccc1-n1cnc(C)c1,Bioorg Med Chem Lett,CHEMBL1642191,0.39,Yes,6.408935393
CHEMBL1648563,"Displacement of [35S]N-[(4R)-10-[(2R)-6-cyano-1,2,3,4-tetrahydro-2-naphthyl]-3,4-dihydro-4-hydroxyspiro[2H-1-benzopyran-2,40-piperidin]-6-yl]methanesulfonamide from human ERG expressed in HEK293 cells",O=c1cc(OCc2ccccc2F)ccn1-c1ccc(OCCN2CCCC2)cc1,Bioorg Med Chem,CHEMBL1642471,0.0043,Yes,8.366531544
CHEMBL1648563,"Displacement of [35S]N-[(4R)-10-[(2R)-6-cyano-1,2,3,4-tetrahydro-2-naphthyl]-3,4-dihydro-4-hydroxyspiro[2H-1-benzopyran-2,40-piperidin]-6-yl]methanesulfonamide from human ERG expressed in HEK293 cells",O=c1cc(OCc2cccc(F)c2)ccn1-c1ccc(OCCN2CCCC2)cc1,Bioorg Med Chem,CHEMBL1642472,0.0029,Yes,8.537602002
CHEMBL1648563,"Displacement of [35S]N-[(4R)-10-[(2R)-6-cyano-1,2,3,4-tetrahydro-2-naphthyl]-3,4-dihydro-4-hydroxyspiro[2H-1-benzopyran-2,40-piperidin]-6-yl]methanesulfonamide from human ERG expressed in HEK293 cells",O=c1cc(OCc2ccc(F)cc2)ccn1-c1ccc(OCCN2CCCC2)cc1,Bioorg Med Chem,CHEMBL584538,0.009,Yes,8.045757491
CHEMBL1648563,"Displacement of [35S]N-[(4R)-10-[(2R)-6-cyano-1,2,3,4-tetrahydro-2-naphthyl]-3,4-dihydro-4-hydroxyspiro[2H-1-benzopyran-2,40-piperidin]-6-yl]methanesulfonamide from human ERG expressed in HEK293 cells",O=c1cc(OCc2cccc(Cl)c2)ccn1-c1ccc(OCCN2CCCC2)cc1,Bioorg Med Chem,CHEMBL1642474,0.0019,Yes,8.721246399
CHEMBL1648563,"Displacement of [35S]N-[(4R)-10-[(2R)-6-cyano-1,2,3,4-tetrahydro-2-naphthyl]-3,4-dihydro-4-hydroxyspiro[2H-1-benzopyran-2,40-piperidin]-6-yl]methanesulfonamide from human ERG expressed in HEK293 cells",O=c1cc(OCc2ccc(Cl)cc2)ccn1-c1ccc(OCCN2CCCC2)cc1,Bioorg Med Chem,CHEMBL1642475,0.0017,Yes,8.769551079
CHEMBL1648563,"Displacement of [35S]N-[(4R)-10-[(2R)-6-cyano-1,2,3,4-tetrahydro-2-naphthyl]-3,4-dihydro-4-hydroxyspiro[2H-1-benzopyran-2,40-piperidin]-6-yl]methanesulfonamide from human ERG expressed in HEK293 cells",COc1ccc(COc2ccn(-c3ccc(OCCN4CCCC4)cc3)c(=O)c2)cc1,Bioorg Med Chem,CHEMBL1642476,0.0012,Yes,8.920818754
CHEMBL1648563,"Displacement of [35S]N-[(4R)-10-[(2R)-6-cyano-1,2,3,4-tetrahydro-2-naphthyl]-3,4-dihydro-4-hydroxyspiro[2H-1-benzopyran-2,40-piperidin]-6-yl]methanesulfonamide from human ERG expressed in HEK293 cells",O=c1cc(OCc2ccc(C(F)(F)F)cc2)ccn1-c1ccc(OCCN2CCCC2)cc1,Bioorg Med Chem,CHEMBL1642477,0.0024,Yes,8.619788758
CHEMBL1648563,"Displacement of [35S]N-[(4R)-10-[(2R)-6-cyano-1,2,3,4-tetrahydro-2-naphthyl]-3,4-dihydro-4-hydroxyspiro[2H-1-benzopyran-2,40-piperidin]-6-yl]methanesulfonamide from human ERG expressed in HEK293 cells",O=c1cc(OCc2ccc3ccccc3c2)ccn1-c1ccc(OCCN2CCCC2)cc1,Bioorg Med Chem,CHEMBL1642479,0.00067,Yes,9.173925197
CHEMBL1648563,"Displacement of [35S]N-[(4R)-10-[(2R)-6-cyano-1,2,3,4-tetrahydro-2-naphthyl]-3,4-dihydro-4-hydroxyspiro[2H-1-benzopyran-2,40-piperidin]-6-yl]methanesulfonamide from human ERG expressed in HEK293 cells",O=c1cc(OCc2ccccc2)ccn1-c1ccc(OCCN2CCCCC2)cc1,Bioorg Med Chem,CHEMBL1642482,0.0058,Yes,8.236572006
CHEMBL1648563,"Displacement of [35S]N-[(4R)-10-[(2R)-6-cyano-1,2,3,4-tetrahydro-2-naphthyl]-3,4-dihydro-4-hydroxyspiro[2H-1-benzopyran-2,40-piperidin]-6-yl]methanesulfonamide from human ERG expressed in HEK293 cells",O=c1cc(OCc2ccccc2)ccn1-c1ccc(OCCN2CCCC2)cc1,Bioorg Med Chem,CHEMBL1641614,0.0081,Yes,8.091514981
CHEMBL1648563,"Displacement of [35S]N-[(4R)-10-[(2R)-6-cyano-1,2,3,4-tetrahydro-2-naphthyl]-3,4-dihydro-4-hydroxyspiro[2H-1-benzopyran-2,40-piperidin]-6-yl]methanesulfonamide from human ERG expressed in HEK293 cells",CCN(CC)CCOc1ccc(-n2ccc(OCc3ccccc3)cc2=O)cc1,Bioorg Med Chem,CHEMBL1642485,0.0098,Yes,8.008773924
CHEMBL1648563,"Displacement of [35S]N-[(4R)-10-[(2R)-6-cyano-1,2,3,4-tetrahydro-2-naphthyl]-3,4-dihydro-4-hydroxyspiro[2H-1-benzopyran-2,40-piperidin]-6-yl]methanesulfonamide from human ERG expressed in HEK293 cells",CC(C)N(CCOc1ccc(-n2ccc(OCc3ccccc3)cc2=O)cc1)C(C)C,Bioorg Med Chem,CHEMBL1642486,0.0043,Yes,8.366531544
CHEMBL1648563,"Displacement of [35S]N-[(4R)-10-[(2R)-6-cyano-1,2,3,4-tetrahydro-2-naphthyl]-3,4-dihydro-4-hydroxyspiro[2H-1-benzopyran-2,40-piperidin]-6-yl]methanesulfonamide from human ERG expressed in HEK293 cells",CN(CCOc1ccc(-n2ccc(OCc3ccccc3)cc2=O)cc1)Cc1ccccc1,Bioorg Med Chem,CHEMBL1642487,0.00081,Yes,9.091514981
CHEMBL1648563,"Displacement of [35S]N-[(4R)-10-[(2R)-6-cyano-1,2,3,4-tetrahydro-2-naphthyl]-3,4-dihydro-4-hydroxyspiro[2H-1-benzopyran-2,40-piperidin]-6-yl]methanesulfonamide from human ERG expressed in HEK293 cells",CN1CCCCC1COc1ccc(-n2ccc(OCc3ccccc3)cc2=O)cc1,Bioorg Med Chem,CHEMBL1642490,0.0058,Yes,8.236572006
CHEMBL1648563,"Displacement of [35S]N-[(4R)-10-[(2R)-6-cyano-1,2,3,4-tetrahydro-2-naphthyl]-3,4-dihydro-4-hydroxyspiro[2H-1-benzopyran-2,40-piperidin]-6-yl]methanesulfonamide from human ERG expressed in HEK293 cells",CN1CCCC1COc1ccc(-n2ccc(OCc3ccccc3)cc2=O)cc1,Bioorg Med Chem,CHEMBL1642491,0.0093,Yes,8.031517051
CHEMBL1648563,"Displacement of [35S]N-[(4R)-10-[(2R)-6-cyano-1,2,3,4-tetrahydro-2-naphthyl]-3,4-dihydro-4-hydroxyspiro[2H-1-benzopyran-2,40-piperidin]-6-yl]methanesulfonamide from human ERG expressed in HEK293 cells",CCN(CC)CCNc1ccc(-n2ccc(OCc3ccccc3)cc2=O)cc1,Bioorg Med Chem,CHEMBL1642492,0.007,Yes,8.15490196
CHEMBL1648563,"Displacement of [35S]N-[(4R)-10-[(2R)-6-cyano-1,2,3,4-tetrahydro-2-naphthyl]-3,4-dihydro-4-hydroxyspiro[2H-1-benzopyran-2,40-piperidin]-6-yl]methanesulfonamide from human ERG expressed in HEK293 cells",CCN(CC)CCN(C)c1ccc(-n2ccc(OCc3ccccc3)cc2=O)cc1,Bioorg Med Chem,CHEMBL1642493,0.0017,Yes,8.769551079
CHEMBL1657597,Displacement of [3H]-dofetilide from human ERG expressed in HEK293 cells,CC(=O)N[C@@H](CCN1[C@@H]2CC[C@H]1C[C@@H](n1c(C)nc3c1CCN(c1ccncn1)C3)C2)c1cccc(F)c1,J Med Chem,CHEMBL1649928,0.01,Yes,8
CHEMBL1670716,Inhibition of human ERG expressed in CHO cells,Cc1cc(C(=O)O)ccc1NC(=O)[C@H](C1CCCCC1)n1c(-c2ccc(Cl)cc2)nc2cc(F)c(F)cc21,Bioorg Med Chem Lett,CHEMBL1615150,0.7,Yes,6.15490196
CHEMBL1676103,Inhibition of human ERG,CCC1(c2ccccc2)C(=O)NC(=O)NC1=O,Eur J Med Chem,CHEMBL40,3019.95172,No,2.52
CHEMBL1676103,Inhibition of human ERG,CCC(CC)c1cn(-c2ccc(F)cc2)c2ccc(Cl)cc12,Eur J Med Chem,CHEMBL299390,1479.10839,No,2.829999999
CHEMBL1676103,Inhibition of human ERG,CCC(=O)c1cn(-c2ccc(F)cc2)c2ccc(Cl)cc12,Eur J Med Chem,CHEMBL53321,1995.26231,No,2.700000001
CHEMBL1676103,Inhibition of human ERG,CCc1cn(-c2ccc(F)cc2)c2ccc(Cl)cc12,Eur J Med Chem,CHEMBL300907,3467.3685,No,2.460000001
CHEMBL1676103,Inhibition of human ERG,COc1c(N2C[C@@H]3CCCN[C@@H]3C2)c(F)cc2c(=O)c(C(=O)O)cn(C3CC3)c12,Eur J Med Chem,CHEMBL32,128.82496,No,3.889999984
CHEMBL1676103,Inhibition of human ERG,COc1cc(Cc2cnc(N)nc2N)cc(OC)c1OC,Eur J Med Chem,CHEMBL22,239.88329,No,3.620000003
CHEMBL1676103,Inhibition of human ERG,CC1=C2C3OC(=O)C(C)C3C(O)CC2(C)C=CC1=O,Eur J Med Chem,CHEMBL1673435,109.64782,No,3.959999998
CHEMBL1676103,Inhibition of human ERG,CCN(CC)CCNC(=O)c1ccc(N)cc1,Eur J Med Chem,CHEMBL640,138.03843,No,3.859999989
CHEMBL1676103,Inhibition of human ERG,O=C(O)c1cn(C2CC2)c2cc(N3CCNCC3)c(F)cc2c1=O,Eur J Med Chem,CHEMBL8,954.99259,No,3.019999998
CHEMBL1676103,Inhibition of human ERG,CN1CCCC1c1cccnc1,Eur J Med Chem,CHEMBL440464,245.47089,No,3.610000003
CHEMBL1676103,Inhibition of human ERG,COc1c(N2CCNC(C)C2)c(F)cc2c(=O)c(C(=O)O)cn(C3CC3)c12,Eur J Med Chem,CHEMBL31,128.82496,No,3.889999984
CHEMBL1676103,Inhibition of human ERG,Cc1c(F)c(N2CCNC(C)C2)cc2c1c(=O)c(C(=O)O)cn2C1CC1,Eur J Med Chem,CHEMBL583,50.11872,No,4.300000029
CHEMBL1676103,Inhibition of human ERG,O=C(O)c1ccc(-n2cc(C3CCN(CCN4CCNC4=O)CC3)c3cc(Cl)ccc32)cc1,Eur J Med Chem,CHEMBL300927,74.13102,No,4.130000024
CHEMBL1676103,Inhibition of human ERG,CCCc1cn(-c2ccc(F)cc2)c2ccc(Cl)cc12,Eur J Med Chem,CHEMBL52348,25703.95783,No,1.59
CHEMBL1676103,Inhibition of human ERG,CC(C)N(CCC(C(N)=O)(c1ccccc1)c1ccccn1)C(C)C,Eur J Med Chem,CHEMBL517,91.20108,No,4.040000019
CHEMBL1676103,Inhibition of human ERG,O=C(O)COCCN1CCN(C(c2ccccc2)c2ccc(Cl)cc2)CC1,Eur J Med Chem,CHEMBL1000,31.62278,No,4.499999953
CHEMBL1676103,Inhibition of human ERG,CC(C)Oc1cc(C(C2=CCC(=O)N=C2)c2ccc(C(C)(C)O)nc2)ccc1OC(F)F,Eur J Med Chem,CHEMBL1673438,56.23413,No,4.250000019
CHEMBL1676103,Inhibition of human ERG,Clc1ccc2c(c1)N=C(N1CCNCC1)c1ccccc1N2,Eur J Med Chem,CHEMBL845,31.62278,No,4.499999953
CHEMBL1676103,Inhibition of human ERG,COC(=O)C1=C(C)NC(C)=C(C(=O)OC)C1c1ccccc1[N+](=O)[O-],Eur J Med Chem,CHEMBL193,50.11872,No,4.300000029
CHEMBL1676103,Inhibition of human ERG,CC(O)c1cn(-c2ccc(F)cc2)c2ccc(Cl)cc12,Eur J Med Chem,CHEMBL52794,4570.8819,No,2.34
CHEMBL1676103,Inhibition of human ERG,Cc1nc2n(c(=O)c1CCN1CCC(c3noc4cc(F)ccc34)CC1)CCCC2,Eur J Med Chem,CHEMBL85,0.14791,Yes,6.830002463
CHEMBL1676103,Inhibition of human ERG,O=C1Cc2cc(CCN3CCN(c4nsc5ccccc45)CC3)c(Cl)cc2N1,Eur J Med Chem,CHEMBL708,0.12589,Yes,6.900008766
CHEMBL1676103,Inhibition of human ERG,CN1CCCCC1CCN1c2ccccc2Sc2ccc([S+](C)[O-])cc21,Eur J Med Chem,CHEMBL1088,0.31623,Yes,6.499996932
CHEMBL1676103,Inhibition of human ERG,CC(C)(C)c1ccc(C(O)CCCN2CCC(C(O)(c3ccccc3)c3ccccc3)CC2)cc1,Eur J Med Chem,CHEMBL17157,0.2138,Yes,6.669992299
CHEMBL1676103,Inhibition of human ERG,COc1ccc(CCN(C)CCCC(C#N)(c2ccc(OC)c(OC)c2)C(C)C)cc1OC,Eur J Med Chem,CHEMBL6966,0.14125,Yes,6.850011544
CHEMBL1676103,Inhibition of human ERG,CCCCN(CCCC)CCC(O)c1cc2c(Cl)cc(Cl)cc2c2cc(C(F)(F)F)ccc12,Eur J Med Chem,CHEMBL1107,0.19498,Yes,6.710009934
CHEMBL1676103,Inhibition of human ERG,CN1CCN(CCCCN2C(=O)CN(/N=C/c3ccc(-c4ccc(Cl)cc4)o3)C2=O)CC1,Eur J Med Chem,CHEMBL123558,0.56234,Yes,6.250001023
CHEMBL1676103,Inhibition of human ERG,O=C(O)Cc1ccc(-n2cc(C3CCN(CCN4CCNC4=O)CC3)c3cc(Cl)ccc32)cc1,Eur J Med Chem,CHEMBL55835,0.57544,Yes,6.239999953
CHEMBL1676103,Inhibition of human ERG,O=C1NCCN1CCN1CCC(c2cn(C3CCCCC3)c3ccc(Cl)cc23)CC1,Eur J Med Chem,CHEMBL53661,0.13804,Yes,6.859995049
CHEMBL1676103,Inhibition of human ERG,COC(=O)Cc1ccc(-n2cc(C3CCN(CCN4CCNC4=O)CC3)c3cc(Cl)ccc32)cc1,Eur J Med Chem,CHEMBL415944,0.13183,Yes,6.879985748
CHEMBL1676103,Inhibition of human ERG,CC(C)(O)c1ccc(C(O)CCCN2CCC(C(O)(c3ccccc3)c3ccccc3)CC2)cc1,Eur J Med Chem,CHEMBL52832,0.45709,Yes,6.33999828
CHEMBL1676103,Inhibition of human ERG,Fc1ccc(-n2cc(C3CCNCC3)c3cc(Cl)ccc32)cc1,Eur J Med Chem,CHEMBL273235,0.20417,Yes,6.690008071
CHEMBL1676103,Inhibition of human ERG,COc1cc(NS(C)(=O)=O)ccc1Nc1c2ccccc2nc2ccccc12,Eur J Med Chem,CHEMBL43,0.20893,Yes,6.679999196
CHEMBL1676103,Inhibition of human ERG,O=c1[nH]c2ccccc2n1CCCN1CCC(n2c(=O)[nH]c3cc(Cl)ccc32)CC1,Eur J Med Chem,CHEMBL219916,0.16218,Yes,6.790002704
CHEMBL1676103,Inhibition of human ERG,CC(C)(C)c1ccc(C(=O)CCCN2CCC(OC(c3ccccc3)c3ccccc3)CC2)cc1,Eur J Med Chem,CHEMBL305660,0.33113,Yes,6.480001471
CHEMBL1676103,Inhibition of human ERG,O=C(c1ccc(F)cc1)N1CCN(CCn2c(=O)[nH]c3ccccc3c2=O)CC1,Eur J Med Chem,CHEMBL1673442,0.10715,Yes,6.970007825
CHEMBL1676103,Inhibition of human ERG,CC(=O)NC(=O)C1CCC(C2N=CC(c3cccc(Br)c3)=N2)CC1,Eur J Med Chem,CHEMBL1673443,0.50119,Yes,6.299997603
CHEMBL1676103,Inhibition of human ERG,O=c1[nH]c2ccccc2n1C1CCN(CCCC(c2ccc(F)cc2)c2ccc(F)cc2)CC1,Eur J Med Chem,CHEMBL1423,0.05495,Yes,7.260032303
CHEMBL1676103,Inhibition of human ERG,O=C1NCCN1CCN1CCC(c2cn(-c3ccc(F)cc3)c3ccc(Cl)cc23)CC1,Eur J Med Chem,CHEMBL12713,0.01479,Yes,7.830031826
CHEMBL1676103,Inhibition of human ERG,CSc1ccc2c(c1)N(CCC1CCCCN1C)c1ccccc1S2,Eur J Med Chem,CHEMBL479,0.0955,Yes,7.019996628
CHEMBL1676103,Inhibition of human ERG,O=C1NCCN1CCN1CCC(c2cn(-c3ccccc3)c3ccc(Cl)cc23)CC1,Eur J Med Chem,CHEMBL443476,0.0871,Yes,7.059981845
CHEMBL1676103,Inhibition of human ERG,COC(=O)c1ccc(-n2cc(C3CCN(CCN4CCNC4=O)CC3)c3cc(Cl)ccc32)cc1,Eur J Med Chem,CHEMBL52999,0.03631,Yes,7.439973751
CHEMBL1676103,Inhibition of human ERG,O=C1NCCN1CCN1CCC(C2CN(c3ccc(F)cc3)c3ccccc32)CC1,Eur J Med Chem,CHEMBL556312,0.02344,Yes,7.630042393
CHEMBL1676103,Inhibition of human ERG,COc1ccc(CCN2CCC(Nc3nc4ccccc4n3Cc3ccc(F)cc3)CC2)cc1,Eur J Med Chem,CHEMBL296419,0.01148,Yes,7.940058112
CHEMBL1676103,Inhibition of human ERG,Cc1cccc(C)c1NC(=O)CN1CCN(CCCC(c2ccc(F)cc2)c2ccc(F)cc2)CC1,Eur J Med Chem,CHEMBL92870,0.01585,Yes,7.799970733
CHEMBL1676103,Inhibition of human ERG,c1ccc(C2=Nc3ccccc3C2C2CCN(c3ccccc3)CC2)cc1,Eur J Med Chem,CHEMBL1671884,0.07943,Yes,7.100015437
CHEMBL1676103,Inhibition of human ERG,CCCCCCCCC(=O)NCc1ccc(CC(O)CO)c(OC)c1,Eur J Med Chem,CHEMBL1671885,0.1,Yes,7
CHEMBL1676103,Inhibition of human ERG,Fc1ccc(-n2cc(C3CCN(CCN4CCN=C4S)CC3)c3ccccc32)cc1,Eur J Med Chem,CHEMBL298978,0.006166,Yes,8.20999648
CHEMBL1676103,Inhibition of human ERG,O=C1NCCN1CCN1CCC(c2cn(-c3ccc(F)cc3)c3ccccc23)CC1,Eur J Med Chem,CHEMBL12780,0.006918,Yes,8.160019442
CHEMBL1676103,Inhibition of human ERG,O=C1NC(=O)C(c2ccccc2)(c2ccccc2)N1,Eur J Med Chem,CHEMBL16,239.88329,No,3.620000003
CHEMBL1676103,Inhibition of human ERG,CCCC(C)C1(CC)C(=O)NC(=O)NC1=O,Eur J Med Chem,CHEMBL448,131.82567,No,3.880000013
CHEMBL1676103,Inhibition of human ERG,CCC1OC(=O)C(C)C(OC2CC(C)(OC)C(O)C(C)O2)C(C)C(OC2OC(C)CC(N(C)C)C2O)C(C)(O)CC(C)C(=O)C(C)C(O)C1(C)O,Eur J Med Chem,CHEMBL1671887,72.4436,No,4.139999976
CHEMBL1676103,Inhibition of human ERG,CCC1OC(=O)C(C)C(OC2CC(C)(OC)C(O)C(C)O2)C(C)C(OC2OC(C)CC(N(C)C)C2O)C(C)(O)CC(C)/C(=N/OCOCCOC)C(C)C(O)C1(C)O,Eur J Med Chem,CHEMBL1671888,36.30781,No,4.439999946
CHEMBL1676103,Inhibition of human ERG,Cc1cc2c(s1)Nc1ccccc1N=C2N1CCN(C)CC1,Eur J Med Chem,CHEMBL715,0.22909,Yes,6.639993868
CHEMBL1676103,Inhibition of human ERG,Cc1nccn1CC1CCc2c(c3ccccc3n2C)C1=O,Eur J Med Chem,CHEMBL46,0.81283,Yes,6.090000276
CHEMBL1676103,Inhibition of human ERG,CNCCC(Oc1ccc(C(F)(F)F)cc1)c1ccccc1,Eur J Med Chem,CHEMBL41,0.45709,Yes,6.33999828
CHEMBL1676103,Inhibition of human ERG,CN(c1nccc(=O)[nH]1)C1CCN(c2nc3ccccc3n2Cc2ccc(F)cc2)CC1,Eur J Med Chem,CHEMBL94454,0.43652,Yes,6.359995853
CHEMBL1676103,Inhibition of human ERG,COc1cc2nc(N3CCN(C(=O)C4COc5ccccc5O4)CC3)nc(N)c2cc1OC,Eur J Med Chem,CHEMBL707,0.58884,Yes,6.230002696
CHEMBL1676103,Inhibition of human ERG,CCN(CC)CCOc1ccc(/C(=C(\Cl)c2ccccc2)c2ccccc2)cc1,Eur J Med Chem,CHEMBL167779,0.18197,Yes,6.740000205
CHEMBL1676103,Inhibition of human ERG,O=C(NCCO)C1CCC(c2ncc(-c3cccc(C(F)(F)F)c3)[nH]2)CC1,Eur J Med Chem,CHEMBL1671892,0.50119,Yes,6.299997603
CHEMBL1676103,Inhibition of human ERG,COc1ccc(C2CCN(CCN3CCOc4ccccc43)CC2)cc1OC,Eur J Med Chem,CHEMBL1671893,0.25119,Yes,6.599997654
CHEMBL1676103,Inhibition of human ERG,COc1ccc(C2CCN(CCC3CCOc4ccccc43)CC2)cc1OC,Eur J Med Chem,CHEMBL94664,0.19953,Yes,6.699991797
CHEMBL1676103,Inhibition of human ERG,c1ccc(-c2[nH]c3ccccc3c2C2CC3CCC(C2)N3c2ccccc2)cc1,Eur J Med Chem,CHEMBL1671894,0.01778,Yes,7.750068243
CHEMBL1676103,Inhibition of human ERG,Cc1cccc(CCN2CCC(C(=O)c3ccc(NS(C)(=O)=O)cc3)CC2)n1,Eur J Med Chem,CHEMBL327980,0.01202,Yes,7.920095532
CHEMBL1676103,Inhibition of human ERG,O=C1NCCN1CCN1CC=C(c2cn(-c3ccc(F)cc3)c3ccc(Cl)cc23)CC1,Eur J Med Chem,CHEMBL12186,0.01,Yes,8
CHEMBL1676103,Inhibition of human ERG,CN1C2CCC1C(C(=O)O)C(OC(=O)c1ccccc1)C2,Eur J Med Chem,CHEMBL1671895,3981.07171,No,2.4
CHEMBL1676103,Inhibition of human ERG,COc1ccc2cc3[n+](cc2c1OC)CCc1cc2c(cc1-3)OCO2,Eur J Med Chem,CHEMBL295124,66.06934,No,4.180000032
CHEMBL1676103,Inhibition of human ERG,CC(C)(O)C(Cl)(Cl)Cl,Eur J Med Chem,CHEMBL1439973,4365.15832,No,2.36
CHEMBL1676103,Inhibition of human ERG,CCNCCc1cccc(C(F)(F)F)c1,Eur J Med Chem,CHEMBL1671896,537.0318,No,3.269999997
CHEMBL1676103,Inhibition of human ERG,CCCCc1oc2ccc(NS(C)(=O)=O)cc2c1C(=O)c1ccc(OCCCN(CCCC)CCCC)cc1,Eur J Med Chem,CHEMBL184412,0.31623,Yes,6.499996932
CHEMBL1676103,Inhibition of human ERG,COC(=O)C1=CCC2CCC1N2C,Eur J Med Chem,CHEMBL412663,169.82437,No,3.769999988
CHEMBL1676103,Inhibition of human ERG,O=C1CCc2ccc(OCCCCN3CCN(c4cccc(Cl)c4Cl)CC3)cc2N1,Eur J Med Chem,CHEMBL1112,0.63096,Yes,6.199998172
CHEMBL1676103,Inhibition of human ERG,Cc1ccc(C23CNCC2C3)cc1,Eur J Med Chem,CHEMBL511099,44.66836,No,4.349999992
CHEMBL1676103,Inhibition of human ERG,CN(C)CCC(c1ccc(Br)cc1)c1ccccn1,Eur J Med Chem,CHEMBL811,0.89125,Yes,6.050000457
CHEMBL1676103,Inhibition of human ERG,NC(=O)N1c2ccccc2C=Cc2ccccc21,Eur J Med Chem,CHEMBL108,104.71285,No,3.98000002
CHEMBL1676103,Inhibition of human ERG,COc1cc(N)c(Cl)cc1C(=O)NC1CCN(Cc2ccccc2)CC1,Eur J Med Chem,CHEMBL325109,0.60256,Yes,6.219999702
CHEMBL1676103,Inhibition of human ERG,CO/N=C1\CN(c2nc3c(cc2F)C(=O)C(C(=O)O)CN3C2CC2)CC12CNC2,Eur J Med Chem,CHEMBL1671899,218.77616,No,3.660000005
CHEMBL1676103,Inhibition of human ERG,CCOP(=O)(Sc1ccccc1)Sc1ccccc1,Eur J Med Chem,CHEMBL1671900,50.11872,No,4.300000029
CHEMBL1676103,Inhibition of human ERG,COC(=O)[C@@H]1[C@H]2CC[C@@H](C[C@@H]1O)N2C,Eur J Med Chem,CHEMBL1232472,416.86938,No,3.380000004
CHEMBL1676103,Inhibition of human ERG,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)[C@H](N)[C@H](C)[C@@H](O)[C@]1(C)O,Eur J Med Chem,CHEMBL290242,316.22777,No,3.499999995
CHEMBL1676103,Inhibition of human ERG,COc1ccc2c(c1)c(CC(=O)O)c(C)n2C(=O)c1ccc(Cl)cc1,Eur J Med Chem,CHEMBL6,301.99517,No,3.520000003
CHEMBL1676103,Inhibition of human ERG,CCCCC1=NC2(CCCC2)C(=O)N1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1,Eur J Med Chem,CHEMBL1513,194.98446,No,3.71
CHEMBL1676103,Inhibition of human ERG,COC(=O)C1=C(C)NC(C)=C(C(=O)OC(C)C)C1c1cccc2c1NON2,Eur J Med Chem,CHEMBL1671902,50.11872,No,4.300000029
CHEMBL1676103,Inhibition of human ERG,CO[C@@H]1[C@@H](O[C@@H]2O[C@H](C)[C@@H](O[C@H]3C[C@@](C)(O)[C@@H](OC(=O)CC(C)C)[C@H](C)O3)[C@H](N(C)C)[C@H]2O)[C@@H](CC=O)C[C@@H](C)[C@@H](O)/C=C\C=C\C[C@@H](C)OC(=O)C[C@H]1OC(C)=O,Eur J Med Chem,CHEMBL1671903,102.3293,No,3.989999997
CHEMBL1676103,Inhibition of human ERG,CCCCCCCN(CC)CCCCc1ccc([N+](=O)[O-])cc1,Eur J Med Chem,CHEMBL182977,0.002188,Yes,8.659952682
CHEMBL1676103,Inhibition of human ERG,CCn1cc(C(=O)O)c(=O)c2cc(F)c(N3CCNC(C)C3)c(F)c21,Eur J Med Chem,CHEMBL561,2398.83292,No,2.62
CHEMBL1676103,Inhibition of human ERG,Cc1cccc(C)c1NC(=O)C1CCCCN1C,Eur J Med Chem,CHEMBL1087,154.88166,No,3.810000005
CHEMBL1676103,Inhibition of human ERG,O=C(NCCN1CCOCC1)c1ccc(Cl)cc1,Eur J Med Chem,CHEMBL86304,79.43282,No,4.100000019
CHEMBL1676103,Inhibition of human ERG,Cc1cc2c(s1)Nc1ccccc1N=C2N1CCN(C)CC1,Eur J Med Chem,CHEMBL715,0.20417,Yes,6.690008071
CHEMBL1676103,Inhibition of human ERG,Cc1ccccc1C(OCCN(C)C)c1ccccc1,Eur J Med Chem,CHEMBL900,0.85114,Yes,6.069998999
CHEMBL1676103,Inhibition of human ERG,CCCN1C[C@H](CSC)C[C@@H]2c3cccc4[nH]cc(c34)C[C@H]21,Eur J Med Chem,CHEMBL531,0.12023,Yes,6.919987153
CHEMBL1676103,Inhibition of human ERG,CCOC(=O)C1(c2ccccc2)CCN(C)CC1,Eur J Med Chem,CHEMBL607,74.13102,No,4.130000024
CHEMBL1676103,Inhibition of human ERG,CC1COc2c(N3CCN(C)CC3)c(F)cc3c(=O)c(C(=O)O)cn1c23,Eur J Med Chem,CHEMBL4,1412.53754,No,2.850000001
CHEMBL1676103,Inhibition of human ERG,CCC(O)c1cn(-c2ccc(F)cc2)c2ccc(Cl)cc12,Eur J Med Chem,CHEMBL53866,2187.76162,No,2.660000001
CHEMBL1676103,Inhibition of human ERG,CCC1OC(=O)C(C)C(OC2CC(C)(OC)C(O)C(C)O2)C(C)C(OC2OC(C)CC(N(C)C)C2O)C(C)(OC)CC(C)C(=O)C(C)C(O)C1(C)O,Eur J Med Chem,CHEMBL1671904,33.11311,No,4.480000028
CHEMBL1676103,Inhibition of human ERG,COc1ccc(Cl)cc1C(=O)NCCc1ccc(S(=O)(=O)NC(=O)NC2CCCCC2)cc1,Eur J Med Chem,CHEMBL472,74.13102,No,4.130000024
CHEMBL1676103,Inhibition of human ERG,CN1CC(=O)N2C(Cc3c([nH]c4ccccc34)C2c2ccc3c(c2)OCO3)C1=O,Eur J Med Chem,CHEMBL1671905,100,No,4
CHEMBL1676103,Inhibition of human ERG,COc1cc2nc(N(C)CCCNC(=O)C3CCCO3)nc(C)c2cc1OC,Eur J Med Chem,CHEMBL1671906,83.17638,No,4.079999985
CHEMBL1676103,Inhibition of human ERG,CCOC(=O)N1CCC(=C2c3ccc(Cl)cc3CCc3cccnc32)CC1,Eur J Med Chem,CHEMBL998,0.17378,Yes,6.760000207
CHEMBL1676103,Inhibition of human ERG,O=C(CCCN1CCC(O)(c2ccc(Cl)cc2)CC1)c1ccc(F)cc1,Eur J Med Chem,CHEMBL54,0.02692,Yes,7.569924944
CHEMBL1676103,Inhibition of human ERG,CN(C)Cc1cn(-c2ccc(F)cc2)c2ccc(Cl)cc12,Eur J Med Chem,CHEMBL301956,0.01096,Yes,7.960189446
CHEMBL1676103,Inhibition of human ERG,CC(C)COCC(CN(Cc1ccccc1)c1ccccc1)N1CCCC1,Eur J Med Chem,CHEMBL1008,0.02291,Yes,7.639974911
CHEMBL1676103,Inhibition of human ERG,CCCCCCCN(CC)CCCC(O)c1ccc(NS(C)(=O)=O)cc1,Eur J Med Chem,CHEMBL533,0.01514,Yes,7.819874125
CHEMBL1676103,Inhibition of human ERG,CS(=O)(=O)Nc1ccc2c(c1)C(O)CC1(CCN(C3CCc4cc(C#N)ccc4C3)CC1)O2,Eur J Med Chem,CHEMBL52627,0.02089,Yes,7.68006156
CHEMBL1676103,Inhibition of human ERG,COc1cc(N)c(Cl)cc1C(=O)NC1CCN(CCCOc2ccc(F)cc2)CC1OC,Eur J Med Chem,CHEMBL1729,0.006761,Yes,8.169989064
CHEMBL1676103,Inhibition of human ERG,O=C(CCCN1CC=C(n2c(=O)[nH]c3ccccc32)CC1)c1ccc(F)cc1,Eur J Med Chem,CHEMBL1108,0.03236,Yes,7.489991487
CHEMBL1676103,Inhibition of human ERG,Nc1ccncc1,Eur J Med Chem,CHEMBL284348,4365.15832,No,2.36
CHEMBL1676103,Inhibition of human ERG,CC(C)(C)N1CCC(c2ccccc2)(c2ccccc2)CC1,Eur J Med Chem,CHEMBL334491,0.85114,Yes,6.069998999
CHEMBL1676103,Inhibition of human ERG,CCCCCCC[N+](CC)(CC)CCCCc1ccc(Cl)cc1,Eur J Med Chem,CHEMBL9484,0.01259,Yes,7.89997427
CHEMBL1676103,Inhibition of human ERG,CCC1=C(C)CC(C(=O)NCCc2ccc(S(=O)(=O)NC(=O)NC3CCC(C)CC3)cc2)C1=O,Eur J Med Chem,CHEMBL1671908,74.13102,No,4.130000024
CHEMBL1676103,Inhibition of human ERG,CC(C(O)c1ccc(O)cc1)N1CCC(Cc2ccccc2)CC1,Eur J Med Chem,CHEMBL305187,0.1,Yes,7
CHEMBL1676103,Inhibition of human ERG,CCN(CC)CC(=O)Nc1c(C)cccc1C,Eur J Med Chem,CHEMBL79,263.0268,No,3.579999999
CHEMBL1676103,Inhibition of human ERG,COc1ccc(CC(=O)Nc2cc3c(cc2[N+](=O)[O-])OC(C)(C)[C@H](O)[C@H]3NC2CC2)cc1,Eur J Med Chem,CHEMBL1671910,43.65158,No,4.360000032
CHEMBL1686824,Inhibition of human ERG,CC(N(C)C)C1(c2ccc(Cl)c(Cl)c2)CCCCC1,Bioorg Med Chem Lett,CHEMBL1684047,40,No,4.397940009
CHEMBL1686824,Inhibition of human ERG,CC(N(C)C)C1(c2ccc(Cl)c(Cl)c2)CCCCC1.Cl,Bioorg Med Chem Lett,CHEMBL1684058,40,No,4.397940009
CHEMBL1763073,Inhibition of human ERG,N#Cc1ccc(C(=O)N2CCC3(CC2)N=C(N)c2c(F)ccc(F)c2N3)cn1,Bioorg Med Chem Lett,CHEMBL447183,0.1,Yes,7
CHEMBL1764797,Displacement of [3H]-dofetilide from human ERG expressed in human HEK293 cells after 90 mins by scintillation counting,COc1ccc([C@H]2CN(CCc3ccc(OC)c(OC)c3)C[C@@H]2CNC(=O)c2cccc(Cl)c2)cc1,Bioorg Med Chem Lett,CHEMBL1760059,0.16,Yes,6.795880017
CHEMBL1764797,Displacement of [3H]-dofetilide from human ERG expressed in human HEK293 cells after 90 mins by scintillation counting,COc1ccc([C@H]2CN(Cc3ccc(OC)c(OC)c3)C[C@@H]2CNC(=O)c2cccc(Cl)c2)cc1,Bioorg Med Chem Lett,CHEMBL1760222,0.6,Yes,6.22184875
CHEMBL1764797,Displacement of [3H]-dofetilide from human ERG expressed in human HEK293 cells after 90 mins by scintillation counting,COc1ccc([C@H]2CN(CCCc3ccc(OC)c(OC)c3)C[C@@H]2CNC(=O)c2cccc(Cl)c2)cc1,Bioorg Med Chem Lett,CHEMBL1760223,0.2,Yes,6.698970004
CHEMBL1764797,Displacement of [3H]-dofetilide from human ERG expressed in human HEK293 cells after 90 mins by scintillation counting,COc1ccc([C@H]2CN(CCc3cccc(OC)c3)C[C@@H]2CNC(=O)c2cccc(Cl)c2)cc1,Bioorg Med Chem Lett,CHEMBL1760226,0.047,Yes,7.327902142
CHEMBL1764797,Displacement of [3H]-dofetilide from human ERG expressed in human HEK293 cells after 90 mins by scintillation counting,COc1ccc(CCN2C[C@H](CNC(=O)c3cccc(Cl)c3)[C@@H](c3ccc(OC)cc3)C2)cc1,Bioorg Med Chem Lett,CHEMBL1760227,0.028,Yes,7.552841969
CHEMBL1764797,Displacement of [3H]-dofetilide from human ERG expressed in human HEK293 cells after 90 mins by scintillation counting,COc1ccc([C@H]2CN(CCc3ccc(OC)c(OC)c3)C[C@@H]2CC(=O)Nc2cccc(Cl)c2)cc1,Bioorg Med Chem Lett,CHEMBL1760234,0.066,Yes,7.180456064
CHEMBL1764797,Displacement of [3H]-dofetilide from human ERG expressed in human HEK293 cells after 90 mins by scintillation counting,COc1ccc([C@H]2CN(CCc3ccc(OC)c(OC)c3)C[C@@H]2CC(=O)N(C)c2cccc(Cl)c2)cc1,Bioorg Med Chem Lett,CHEMBL1760235,0.029,Yes,7.537602002
CHEMBL1764797,Displacement of [3H]-dofetilide from human ERG expressed in human HEK293 cells after 90 mins by scintillation counting,COc1ccc([C@H]2CN(CCc3ccc(OC)c(OC)c3)C[C@@H]2CC(=O)NCc2cccc(Cl)c2)cc1,Bioorg Med Chem Lett,CHEMBL1760236,0.034,Yes,7.468521083
CHEMBL1764797,Displacement of [3H]-dofetilide from human ERG expressed in human HEK293 cells after 90 mins by scintillation counting,COc1ccc([C@H]2CN(CCc3ccc(OC)c(OC)c3)C[C@@H]2CCNC(=O)c2cccc(Cl)c2)cc1,Bioorg Med Chem Lett,CHEMBL1760237,0.056,Yes,7.251811973
CHEMBL1764797,Displacement of [3H]-dofetilide from human ERG expressed in human HEK293 cells after 90 mins by scintillation counting,COc1ccc([C@H]2CN(CCc3ccc(OC)c(OC)c3)C[C@@H]2Cc2nc3ccc(Cl)cc3[nH]2)cc1,Bioorg Med Chem Lett,CHEMBL1760242,0.028,Yes,7.552841969
CHEMBL1764797,Displacement of [3H]-dofetilide from human ERG expressed in human HEK293 cells after 90 mins by scintillation counting,COc1ccc([C@H]2CN(CCc3ccc(OC)c(OC)c3)C[C@@H]2CCc2nc3ccc(Cl)cc3[nH]2)cc1,Bioorg Med Chem Lett,CHEMBL1760243,0.016,Yes,7.795880017
CHEMBL1764797,Displacement of [3H]-dofetilide from human ERG expressed in human HEK293 cells after 90 mins by scintillation counting,COc1ccc([C@H]2CN(CCc3ccc(OC)c(OC)c3)C[C@@H]2CCc2cc3ccc(Cl)cc3[nH]2)cc1,Bioorg Med Chem Lett,CHEMBL1760244,0.045,Yes,7.346787486
CHEMBL1764797,Displacement of [3H]-dofetilide from human ERG expressed in human HEK293 cells after 90 mins by scintillation counting,COc1ccc([C@H]2CN(CCc3ccc(OC)c(OC)c3)C[C@@H]2CC(=O)Nc2cccc(Cl)c2)cc1,Bioorg Med Chem Lett,CHEMBL1760234,0.002,Yes,8.698970004
CHEMBL1764797,Displacement of [3H]-dofetilide from human ERG expressed in human HEK293 cells after 90 mins by scintillation counting,COc1ccc([C@H]2CN(CCCC3CCOCC3)C[C@@H]2CC(=O)Nc2cccc(Cl)c2)cc1,Bioorg Med Chem Lett,CHEMBL1760245,0.37,Yes,6.431798276
CHEMBL1764797,Displacement of [3H]-dofetilide from human ERG expressed in human HEK293 cells after 90 mins by scintillation counting,COc1ccc([C@H]2CN(CCC3CCOCC3)C[C@@H]2CC(=O)Nc2cccc(Cl)c2)cc1,Bioorg Med Chem Lett,CHEMBL1760246,0.12,Yes,6.920818754
CHEMBL1764797,Displacement of [3H]-dofetilide from human ERG expressed in human HEK293 cells after 90 mins by scintillation counting,COc1ccc([C@H]2CN(CCC3CCS(=O)(=O)CC3)C[C@@H]2CC(=O)Nc2cccc(Cl)c2)cc1,Bioorg Med Chem Lett,CHEMBL1760247,0.29,Yes,6.537602002
CHEMBL1764797,Displacement of [3H]-dofetilide from human ERG expressed in human HEK293 cells after 90 mins by scintillation counting,COc1ccc([C@H]2CN(CCCN(C)S(=O)(=O)c3ccccc3)C[C@@H]2CC(=O)Nc2cccc(Cl)c2)cc1,Bioorg Med Chem Lett,CHEMBL1760250,0.14,Yes,6.853871964
CHEMBL1764797,Displacement of [3H]-dofetilide from human ERG expressed in human HEK293 cells after 90 mins by scintillation counting,COc1ccc([C@H]2CN(CCc3ccc(OC)c(OC)c3)C[C@@H]2CNC(=O)c2cccc(Cl)c2)cc1,Bioorg Med Chem Lett,CHEMBL1760059,0.11,Yes,6.958607315
CHEMBL1764027,Inhibition hERG by patch clamp method,CC(=O)Nc1cccc(C2CCN(CCCn3c(-c4ccc(Cl)cc4)nc4ccccc43)CC2)c1,Bioorg Med Chem Lett,CHEMBL1761103,0.003,Yes,8.522878745
CHEMBL1769661,Displacement of labeled dofetilide human ERG,CN1CCCC(n2nc(Cc3ccc(Cl)cc3)c3ccccc3c2=O)CC1,J Med Chem,CHEMBL639,0.1,Yes,7
CHEMBL1769661,Displacement of labeled dofetilide human ERG,O=c1c2ccccc2c(Cc2ccc(Cl)cc2)nn1C[C@H]1CCCN1CCCCc1ccc(OCCCN2CCCCCC2)cc1,J Med Chem,CHEMBL1767164,0.05012,Yes,7.299988938
CHEMBL1772211,Displacement of [35S]MK499 from human ERG expressed in HEK cells,CC(C)Oc1ccc(F)cc1-c1ccc(N2CCC(CNC(=O)c3ccc(-c4nc5cc(C#N)cc(C(C)C)c5o4)cc3)CC2)nc1,Bioorg Med Chem Lett,CHEMBL1682748,0.056,Yes,7.251811973
CHEMBL1771845,Inhibition of human ERG,Cc1cc(N2CCC(C3CCN(c4ncc(Cl)cn4)CC3)CC2)nc(C#N)n1,Bioorg Med Chem Lett,CHEMBL1771093,0.277,Yes,6.557520231
CHEMBL1771850,Inhibition of human ERG by patch clamp technique,Clc1cnc(N2CCC([C@H]3C[C@H]3CCOc3ccc(-n4ccnn4)cn3)CC2)nc1,Bioorg Med Chem Lett,CHEMBL1771102,44,No,4.356547324
CHEMBL1781167,Inhibition of human ERG by patch clamp method,CC(C)(C)OC[C@@H]1C(=O)NCCN1C(=O)C[C@H](N)Cc1cc(F)c(F)cc1F,Bioorg Med Chem Lett,CHEMBL1779710,79.6,No,4.099086932
CHEMBL1781403,Inhibition of human ERG,CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)[C@H](OCC(=O)NC)[C@H](C)[C@@H](O)[C@]1(C)O,Bioorg Med Chem Lett,CHEMBL572996,411,No,3.386158178
CHEMBL1780626,Inhibition of human ERG by HT patch clamp assay,Cc1c2c(n3c1CCCN1CCCC[C@@H]1CNc1cc-3ccc1C(N)=O)CC(C)(C)CC2=O,Bioorg Med Chem Lett,CHEMBL1779532,0.9,Yes,6.045757491
CHEMBL1780626,Inhibition of human ERG by HT patch clamp assay,Cc1c2c(n3c1CCCN1CC[C@H](CNc4cc-3ccc4C(N)=O)C1)CC(C)(C)CC2=O,Bioorg Med Chem Lett,CHEMBL1779536,0.44,Yes,6.356547324
CHEMBL1786160,Displacement of labeled dofetilide from human ERG,CO[C@@H]1COCC[C@@H]1N[C@@H]1CC[C@@](C(=O)N2CCN(c3ccnc(C(F)(F)F)n3)CC2)(C(C)C)C1,Bioorg Med Chem Lett,CHEMBL1782569,35.9,No,4.444905551
CHEMBL1786160,Displacement of labeled dofetilide from human ERG,CO[C@@H]1COCC[C@@H]1N[C@@H]1CC[C@@](C(=O)N2CCN(c3cc(C(F)(F)F)ncn3)CC2)(C(C)C)C1,Bioorg Med Chem Lett,CHEMBL1782570,42.6,No,4.370590401
CHEMBL1786160,Displacement of labeled dofetilide from human ERG,CO[C@@H]1COCC[C@@H]1N[C@@H]1CC[C@@](C(=O)N2CCN(c3cc(C(F)(F)F)cnn3)CC2)(C(C)C)C1,Bioorg Med Chem Lett,CHEMBL1782572,31.3,No,4.504455662
CHEMBL1786160,Displacement of labeled dofetilide from human ERG,CO[C@@H]1COCC[C@@H]1N[C@@H]1CC[C@@](C(=O)N2CCN(c3nc(C(F)(F)F)cs3)CC2)(C(C)C)C1,Bioorg Med Chem Lett,CHEMBL1782574,3900,No,2.408935393
CHEMBL1786160,Displacement of labeled dofetilide from human ERG,CC(C)[C@]1(C(=O)N2CCN(c3cc(C(F)(F)F)ccn3)CC2)CC[C@@H](N[C@H]2CCOC[C@H]2O)C1,Bioorg Med Chem Lett,CHEMBL1782580,0.3,Yes,6.522878745
CHEMBL1786160,Displacement of labeled dofetilide from human ERG,CO[C@@H]1COCC[C@@H]1N(C)[C@@H]1CC[C@@](C(=O)N2CCN(c3cc(C(F)(F)F)cnn3)CC2)(C(C)C)C1,Bioorg Med Chem Lett,CHEMBL1782378,52.8,No,4.277366077
CHEMBL1787063,Inhibition of human ERG,Cc1noc(C)c1CCC1CCN(S(=O)(=O)C[C@](C)(C[C@H](C)c2ncc(F)cn2)N(O)C=O)CC1,Bioorg Med Chem Lett,CHEMBL1615187,65,No,4.187086643
CHEMBL1788065,Inhibition of human Erg by patch clamp assay,Cc1nc2ccccc2n1C1CC2CCC(C1)N2CCC1(c2cccc(F)c2)CCN(C(=O)C(C)(C)C(=O)O)CC1,J Med Chem,CHEMBL1784406,56.23413,No,4.250000019
CHEMBL1788065,Inhibition of human Erg by patch clamp assay,Cc1nc2ccccc2n1C1CC2CCC(C1)N2CCC1(c2cccc(F)c2)CCN(C(=O)C2(C(=O)O)CCC2)CC1,J Med Chem,CHEMBL1784407,44.66836,No,4.349999992
CHEMBL1788065,Inhibition of human Erg by patch clamp assay,Cc1nc2ccccc2n1C1CC2CCC(C1)N2CCC1(c2ccccc2)CCN(C(=O)c2ccccc2C(=O)O)CC1,J Med Chem,CHEMBL1784408,125.89254,No,3.900000004
CHEMBL1788065,Inhibition of human Erg by patch clamp assay,Cc1nc2ccccc2n1C1CC2CCC(C1)N2CCC1(c2ccccc2)CCN(C(=O)c2cccc(C(=O)O)c2)CC1,J Med Chem,CHEMBL1784409,50.11872,No,4.300000029
CHEMBL1788065,Inhibition of human Erg by patch clamp assay,Cc1nc2ccccc2n1C1CC2CCC(C1)N2CCC1(c2ccccc2)CCN(C(=O)c2cccc(-c3nnn[nH]3)c2)CC1,J Med Chem,CHEMBL1784467,31.62278,No,4.499999953
CHEMBL1788065,Inhibition of human Erg by patch clamp assay,Cc1nc2ccccc2n1C1CC2CCC(C1)N2CCC1(c2ccccc2)CCN(C(=O)c2cccc(C(=O)NO)c2)CC1,J Med Chem,CHEMBL1784468,79.43282,No,4.100000019
CHEMBL1788065,Inhibition of human Erg by patch clamp assay,COC(=O)c1cccc(C(=O)N2CCC(CCN3C4CCC3CC(n3c(C)nc5ccccc53)C4)(c3ccccc3)CC2)c1,J Med Chem,CHEMBL1784472,0.79433,Yes,6.099999035
CHEMBL1788065,Inhibition of human Erg by patch clamp assay,Cc1nc2ccccc2n1C1CC2CCC(C1)N2CCC1(c2ccccc2)CCN(C(=O)c2cccc(S(N)(=O)=O)c2)CC1,J Med Chem,CHEMBL1784473,63.09573,No,4.200000031
CHEMBL1788065,Inhibition of human Erg by patch clamp assay,CNS(=O)(=O)c1cccc(C(=O)N2CCC(CCN3C4CCC3CC(n3c(C)nc5ccccc53)C4)(c3ccccc3)CC2)c1,J Med Chem,CHEMBL1784476,63.09573,No,4.200000031
CHEMBL1788065,Inhibition of human Erg by patch clamp assay,Cc1nc2ccccc2n1C1CC2CCC(C1)N2CCC1(c2cccc(F)c2)CCN(C(=O)c2cc(S(N)(=O)=O)ccc2F)CC1,J Med Chem,CHEMBL1784511,41.68694,No,4.379999983
CHEMBL1788065,Inhibition of human Erg by patch clamp assay,Cc1nc2ccccc2n1C1CC2CCC(C1)N2CCC1(c2cccc(F)c2)CCN(C(=O)c2c(Cl)ccc(S(N)(=O)=O)c2Cl)CC1,J Med Chem,CHEMBL1784513,52.48075,No,4.279999967
CHEMBL1788065,Inhibition of human Erg by patch clamp assay,Cc1nc2ccccc2n1C1CC2CCC(C1)N2CCC1(c2cccc(F)c2)CCN(C(=O)c2cc(S(=O)(=O)NC3CCCC3)c(F)cc2Cl)CC1,J Med Chem,CHEMBL1784515,30.90295,No,4.510000061
CHEMBL1788065,Inhibition of human Erg by patch clamp assay,CCNS(=O)(=O)c1cc(C(=O)N2CCC(CCN3C4CCC3CC(n3c(C)nc5ccccc53)C4)(c3cccc(F)c3)CC2)c(Cl)cc1F,J Med Chem,CHEMBL1784516,30.19952,No,4.51999996
CHEMBL1788065,Inhibition of human Erg by patch clamp assay,Cc1nc2ccccc2n1C1CC2CCC(C1)N2CCC1(c2cccc(F)c2)CCN(C(=O)c2cc(NS(C)(=O)=O)c(F)cc2Cl)CC1,J Med Chem,CHEMBL1782081,31.62278,No,4.499999953
CHEMBL1788065,Inhibition of human Erg by patch clamp assay,Cc1nc2ccccc2n1C1CC2CCC(C1)N2CCC1(c2cccc(F)c2)CCN(C(=O)c2cc(NS(C)(=O)=O)c(F)cc2F)CC1,J Med Chem,CHEMBL1784523,100,No,4
CHEMBL1788065,Inhibition of human Erg by patch clamp assay,Cc1nc2ccccc2n1C1CC2CCC(C1)N2CCC1(c2cccc(F)c2)CCN(C(=O)c2c(F)ccc(NS(C)(=O)=O)c2F)CC1,J Med Chem,CHEMBL1784524,36.30781,No,4.439999946
CHEMBL1804921,Inhibition of human hERG,Cc1nnc(N2CC[C@@H](F)C2)c2nn(-c3ccc(OCC(F)(F)F)cc3)c(C)c12,Bioorg Med Chem Lett,CHEMBL1801188,0.316,Yes,6.500312917
CHEMBL1803706,Inhibition of Kv11.1 channel,CS(=O)(=O)Nc1ccc2ccc3ncc(-c4ccccc4)cc3c(=O)c2c1,J Med Chem,CHEMBL1803004,0.29,Yes,6.537602002
CHEMBL1816132,Inhibition of human Erg expressed in human HEK293 cells by patch-clamp electrophysiological assay,CC(=O)Nc1cccc(Nc2ncnc(N3CCC(OCc4ccc(C(C)C)cc4)CC3)n2)c1C,J Med Chem,CHEMBL1813044,0.44,Yes,6.356547324
CHEMBL1820160,Inhibition of human ERG expressed in human HEK293 cells by patch-clamp electrophysiology,CC(C)CNc1nc(N2CCN(CC3CCCOC3)CC2)ncc1C(=O)NCc1ccccc1,Bioorg Med Chem Lett,CHEMBL1818218,0.58,Yes,6.236572006
CHEMBL1820233,Binding affinity to human ERG by radioligand displacement assay,COc1cc(-c2cn(Cc3cccc(OC(F)(F)F)c3)nn2)ccc1-n1cnc(C)c1,Bioorg Med Chem Lett,CHEMBL1818825,0.72,Yes,6.142667504
CHEMBL1820233,Binding affinity to human ERG by radioligand displacement assay,COc1cc(-c2cn(Cc3cc(C(C)(C)C)cc(C(C)(C)C)c3)nn2)ccc1-n1cnc(C)c1,Bioorg Med Chem Lett,CHEMBL1818826,0.32,Yes,6.494850022
CHEMBL1820233,Binding affinity to human ERG by radioligand displacement assay,COc1cc(-c2cn(Cc3cc(Br)cc(Br)c3)nn2)ccc1-n1cnc(C)c1,Bioorg Med Chem Lett,CHEMBL1818827,0.1,Yes,7
CHEMBL1820233,Binding affinity to human ERG by radioligand displacement assay,COc1cc(-c2cn(Cc3cc(C(F)(F)F)cc(C(F)(F)F)c3)nn2)ccc1-n1cnc(C)c1,Bioorg Med Chem Lett,CHEMBL1818828,0.39,Yes,6.408935393
CHEMBL1820233,Binding affinity to human ERG by radioligand displacement assay,COc1cc(-c2cn(Cc3ccc(C(C)(C)C)cc3)nn2)ccc1-n1cnc(C)c1,Bioorg Med Chem Lett,CHEMBL1818829,0.39,Yes,6.408935393
CHEMBL1820248,Inhibition of wild-type human ERG channel expressed in HEK293 cells assessed as blockade of potassium tail current by whole-cell patch clamp technique,CCCCN1CCCC[C@@H]1C(=O)Nc1c(C)cccc1C.Cl,Eur J Med Chem,CHEMBL2447962,84,No,4.075720714
CHEMBL1820249,Inhibition of human ERG Y652A mutant channel expressed in HEK293 cells assessed as blockade of potassium tail current by whole-cell patch clamp technique,CCCCN1CCCC[C@@H]1C(=O)Nc1c(C)cccc1C.Cl,Eur J Med Chem,CHEMBL2447962,276,No,3.559090918
CHEMBL1820250,Inhibition of human ERG F656A mutant channel expressed in HEK293 cells assessed as blockade of potassium tail current by whole-cell patch clamp technique,CCCCN1CCCC[C@@H]1C(=O)Nc1c(C)cccc1C.Cl,Eur J Med Chem,CHEMBL2447962,758,No,3.120330794
CHEMBL1820248,Inhibition of wild-type human ERG channel expressed in HEK293 cells assessed as blockade of potassium tail current by whole-cell patch clamp technique,CCCCN1CCCCC1C(=O)Nc1c(C)cccc1C.Cl,Eur J Med Chem,CHEMBL1200396,32,No,4.494850022
CHEMBL1820249,Inhibition of human ERG Y652A mutant channel expressed in HEK293 cells assessed as blockade of potassium tail current by whole-cell patch clamp technique,CCCCN1CCCCC1C(=O)Nc1c(C)cccc1C.Cl,Eur J Med Chem,CHEMBL1200396,265,No,3.576754126
CHEMBL1820250,Inhibition of human ERG F656A mutant channel expressed in HEK293 cells assessed as blockade of potassium tail current by whole-cell patch clamp technique,CCCCN1CCCCC1C(=O)Nc1c(C)cccc1C.Cl,Eur J Med Chem,CHEMBL1200396,866,No,3.062482108
CHEMBL1820252,Inhibition of human ERG Y652A mutant channel expressed in CHO cells by whole-cell patch clamp technique,CCCCN1CCCCC1C(=O)Nc1c(C)cccc1C.Cl,Eur J Med Chem,CHEMBL1200396,95,No,4.022276395
CHEMBL1820249,Inhibition of human ERG Y652A mutant channel expressed in HEK293 cells assessed as blockade of potassium tail current by whole-cell patch clamp technique,CCCCN1CCCC[C@H]1C(=O)Nc1c(C)cccc1C.Cl,Eur J Med Chem,CHEMBL1200749,278,No,3.555955204
CHEMBL1820250,Inhibition of human ERG F656A mutant channel expressed in HEK293 cells assessed as blockade of potassium tail current by whole-cell patch clamp technique,CCCCN1CCCC[C@H]1C(=O)Nc1c(C)cccc1C.Cl,Eur J Med Chem,CHEMBL1200749,1013,No,2.994390555
CHEMBL1820252,Inhibition of human ERG Y652A mutant channel expressed in CHO cells by whole-cell patch clamp technique,CCCCN1CCCC[C@H]1C(=O)Nc1c(C)cccc1C.Cl,Eur J Med Chem,CHEMBL1200749,83,No,4.080921908
CHEMBL1820401,Inhibition of human ERG by radioligand binding assay,O=C(/C=C/c1ccc(CNCCc2c(-c3cccs3)[nH]c3ccccc23)cc1)NO,J Med Chem,CHEMBL1819258,0.48,Yes,6.318758763
CHEMBL1820401,Inhibition of human ERG by radioligand binding assay,Cc1noc(C)c1-c1[nH]c2ccccc2c1CCNCc1ccc(/C=C/C(=O)NO)cc1,J Med Chem,CHEMBL1819259,31.24,No,4.505288975
CHEMBL1827211,Inhibition of human ERG,CN(C)C1(CNC(=O)N2CCC(c3nc(-c4ccc5ccccc5n4)no3)CC2)CCCC1,Bioorg Med Chem Lett,CHEMBL1822444,38,No,4.420216403
CHEMBL1827362,Displacement of [3H]dofetilide from human recombinant ERG by Competitive binding assay,c1ccc(-c2ccc(OCCCN3CCCCC3)cc2)cc1,Bioorg Med Chem Lett,CHEMBL1823340,0.42,Yes,6.37675071
CHEMBL1827362,Displacement of [3H]dofetilide from human recombinant ERG by Competitive binding assay,CC(C)N1CCN(C(=O)N2CCC(c3ccccc3)CC2)CC1,Bioorg Med Chem Lett,CHEMBL374493,52.5,No,4.279840697
CHEMBL1827362,Displacement of [3H]dofetilide from human recombinant ERG by Competitive binding assay,COc1cc2c(cc1OC)CN(C(=O)N1CCN(C(C)C)CC1)CC2,Bioorg Med Chem Lett,CHEMBL218992,115,No,3.93930216
CHEMBL1827362,Displacement of [3H]dofetilide from human recombinant ERG by Competitive binding assay,CC(C)N1CCN(C(=O)N2CCc3ccccc3C2)CC1,Bioorg Med Chem Lett,CHEMBL219803,115,No,3.93930216
CHEMBL1827362,Displacement of [3H]dofetilide from human recombinant ERG by Competitive binding assay,CC(C)N1CCN(C(=O)N2CCC(C(C)(C)C)CC2)CC1,Bioorg Med Chem Lett,CHEMBL219128,66.92308,No,4.17442408
CHEMBL1827362,Displacement of [3H]dofetilide from human recombinant ERG by Competitive binding assay,CC(C)N1CCN(C(=O)N2CCC(Cc3ccccc3)CC2)CC1,Bioorg Med Chem Lett,CHEMBL219074,37.61905,No,4.424592176
CHEMBL1827362,Displacement of [3H]dofetilide from human recombinant ERG by Competitive binding assay,CC(C)N1CCN(C(=O)N2CCC(C(=O)OC(C)(C)C)CC2)CC1,Bioorg Med Chem Lett,CHEMBL218410,101.11111,No,3.995201122
CHEMBL1827362,Displacement of [3H]dofetilide from human recombinant ERG by Competitive binding assay,CC(C)N1CCN(C(=O)N2CCC(C(=O)N3CC4CCC(CC4)C3)CC2)CC1,Bioorg Med Chem Lett,CHEMBL218834,115,No,3.93930216
CHEMBL1827362,Displacement of [3H]dofetilide from human recombinant ERG by Competitive binding assay,CC(C)N1CCN(C(=O)N2CCC(NC(=O)C3CCCC3)CC2)CC1,Bioorg Med Chem Lett,CHEMBL220407,156.66667,No,3.805023388
CHEMBL1827362,Displacement of [3H]dofetilide from human recombinant ERG by Competitive binding assay,O=C(N1CCN(C2CC2)CC1)N1Cc2ccccc2C1,Bioorg Med Chem Lett,CHEMBL373860,52.5,No,4.279840697
CHEMBL1827362,Displacement of [3H]dofetilide from human recombinant ERG by Competitive binding assay,O=C(NCc1ccc(C(F)(F)F)cc1)N1CCC[C@H]1CN1CCCC1,Bioorg Med Chem Lett,CHEMBL218836,40,No,4.397940009
CHEMBL1827362,Displacement of [3H]dofetilide from human recombinant ERG by Competitive binding assay,Cn1c(-c2ccc(OC3CCN(C4CCC4)CC3)cc2)nc2c(C(F)(F)F)cccc2c1=O,Bioorg Med Chem Lett,CHEMBL453894,0.35,Yes,6.455931956
CHEMBL1827362,Displacement of [3H]dofetilide from human recombinant ERG by Competitive binding assay,O=c1c2ccccc2nc(-c2ccc(OCCCN3CCCCC3)cc2)n1Cc1ccccc1,Bioorg Med Chem Lett,CHEMBL487059,0.17,Yes,6.769551079
CHEMBL1827362,Displacement of [3H]dofetilide from human recombinant ERG by Competitive binding assay,O=c1c2ccccc2nc(-c2ccc(OCCCN3CCCCC3)cc2)n1-c1ccccc1,Bioorg Med Chem Lett,CHEMBL487060,0.46,Yes,6.337242168
CHEMBL1827362,Displacement of [3H]dofetilide from human recombinant ERG by Competitive binding assay,Cc1nc2c(C(F)(F)F)cccc2c(=O)n1-c1ccc(OCCCN2CCCC2)cc1,Bioorg Med Chem Lett,CHEMBL476322,0.35,Yes,6.455931956
CHEMBL1827362,Displacement of [3H]dofetilide from human recombinant ERG by Competitive binding assay,O=c1c2ccccc2ncn1-c1ccc(OCCCN2CCCC2)cc1,Bioorg Med Chem Lett,CHEMBL518431,0.71,Yes,6.148741651
CHEMBL1827362,Displacement of [3H]dofetilide from human recombinant ERG by Competitive binding assay,CC1=C(c2ccc(OCCCN3CCCC3)cc2)Oc2ccccc2S1(=O)=O,Bioorg Med Chem Lett,CHEMBL556100,0.47,Yes,6.327902142
CHEMBL1827362,Displacement of [3H]dofetilide from human recombinant ERG by Competitive binding assay,C[C@H]1[C@H](c2ccc(OCCCN3CCCC3)cc2)Oc2ccccc2S1(=O)=O,Bioorg Med Chem Lett,CHEMBL1823180,0.44,Yes,6.356547324
CHEMBL1827362,Displacement of [3H]dofetilide from human recombinant ERG by Competitive binding assay,CC1=C(c2ccc(OCCCN3CCCC3)cc2)Oc2ccccc2S1,Bioorg Med Chem Lett,CHEMBL560923,0.0044,Yes,8.356547324
CHEMBL1827362,Displacement of [3H]dofetilide from human recombinant ERG by Competitive binding assay,C[C@H]1Sc2ccccc2O[C@@H]1c1ccc(OCCCN2CCCC2)cc1,Bioorg Med Chem Lett,CHEMBL550393,0.025,Yes,7.602059991
CHEMBL1827362,Displacement of [3H]dofetilide from human recombinant ERG by Competitive binding assay,c1ccc([C@@H]2Sc3ccccc3O[C@@H]2c2ccc(OCCCN3CCCC3)cc2)cc1,Bioorg Med Chem Lett,CHEMBL564514,0.012,Yes,7.920818754
CHEMBL1827362,Displacement of [3H]dofetilide from human recombinant ERG by Competitive binding assay,CC[C@@H]1Sc2ccccc2O[C@@H]1c1ccc(OCCCN2CCCC2)cc1,Bioorg Med Chem Lett,CHEMBL549433,0.011,Yes,7.958607315
CHEMBL1827362,Displacement of [3H]dofetilide from human recombinant ERG by Competitive binding assay,C[C@@H]1Sc2ccccc2O[C@@H]1c1ccc(OCCCN2CCCC2)cc1,Bioorg Med Chem Lett,CHEMBL557853,0.005,Yes,8.301029996
CHEMBL1827362,Displacement of [3H]dofetilide from human recombinant ERG by Competitive binding assay,Nc1cnc(-c2cc3sc(N4CCC(N5CCCCC5)CC4)nc3cn2)cn1,Bioorg Med Chem Lett,CHEMBL575453,132.85714,No,3.876615101
CHEMBL1827362,Displacement of [3H]dofetilide from human recombinant ERG by Competitive binding assay,Nc1ccc(-c2cc3sc(N4CCC(N5CCCCC5)CC4)nc3cn2)cn1,Bioorg Med Chem Lett,CHEMBL575685,190,No,3.721246399
CHEMBL1827362,Displacement of [3H]dofetilide from human recombinant ERG by Competitive binding assay,Oc1ccc(-c2cc3sc(N4CCC(N5CCCCC5)CC4)nc3cn2)cn1,Bioorg Med Chem Lett,CHEMBL578834,190,No,3.721246399
CHEMBL1827362,Displacement of [3H]dofetilide from human recombinant ERG by Competitive binding assay,COc1cc(-c2cc3sc(N4CCC(N5CCCCC5)CC4)nc3cn2)ccn1,Bioorg Med Chem Lett,CHEMBL575022,0.98901,Yes,6.004799317
CHEMBL1827362,Displacement of [3H]dofetilide from human recombinant ERG by Competitive binding assay,COc1cc(-c2cnc3nc(N4CCC(N5CCCCC5)CC4)sc3c2)ccn1,Bioorg Med Chem Lett,CHEMBL573034,0.20408,Yes,6.690199554
CHEMBL1827362,Displacement of [3H]dofetilide from human recombinant ERG by Competitive binding assay,Fc1cc(-c2cnc3nc(N4CCC(N5CCCCC5)CC4)sc3c2)ccn1,Bioorg Med Chem Lett,CHEMBL583582,0.20408,Yes,6.690199554
CHEMBL1827362,Displacement of [3H]dofetilide from human recombinant ERG by Competitive binding assay,Nc1cnc(-c2cnc3nc(N4CCC(N5CCCCC5)CC4)sc3c2)cn1,Bioorg Med Chem Lett,CHEMBL573493,40,No,4.397940009
CHEMBL1827362,Displacement of [3H]dofetilide from human recombinant ERG by Competitive binding assay,CC(=O)Nc1ccc(-c2cnc3nc(N4CCC(N5CCCCC5)CC4)sc3c2)cn1,Bioorg Med Chem Lett,CHEMBL574387,40,No,4.397940009
CHEMBL1827362,Displacement of [3H]dofetilide from human recombinant ERG by Competitive binding assay,Oc1ccc(-c2cnc3nc(N4CCC(N5CCCCC5)CC4)sc3c2)cn1,Bioorg Med Chem Lett,CHEMBL574393,323.33333,No,3.490349525
CHEMBL1827362,Displacement of [3H]dofetilide from human recombinant ERG by Competitive binding assay,COc1ccc(-c2cnc3nc(N4CCC(N5CCCCC5)CC4)sc3c2)cn1,Bioorg Med Chem Lett,CHEMBL573485,0.10101,Yes,6.995635629
CHEMBL1827362,Displacement of [3H]dofetilide from human recombinant ERG by Competitive binding assay,Fc1ccc(-c2cnc3nc(N4CCC(N5CCCCC5)CC4)sc3c2)cn1,Bioorg Med Chem Lett,CHEMBL574837,0.30928,Yes,6.509648163
CHEMBL1827362,Displacement of [3H]dofetilide from human recombinant ERG by Competitive binding assay,N#Cc1cc(-c2cnc3nc(N4CCC(N5CCCCC5)CC4)sc3c2)ccc1F,Bioorg Med Chem Lett,CHEMBL584766,0.10101,Yes,6.995635629
CHEMBL1827362,Displacement of [3H]dofetilide from human recombinant ERG by Competitive binding assay,C[C@@H]1CCCN1CCc1ccc(-c2ccc(S(=O)(=O)NCc3ccccc3)cc2)cc1,Bioorg Med Chem Lett,CHEMBL558456,0.57143,Yes,6.243036963
CHEMBL1827362,Displacement of [3H]dofetilide from human recombinant ERG by Competitive binding assay,C[C@@H]1CCCN1CCc1ccc(-c2ccc(S(=O)(=O)Nc3ccccc3)cc2)cc1,Bioorg Med Chem Lett,CHEMBL552279,0.2967,Yes,6.527682454
CHEMBL1827362,Displacement of [3H]dofetilide from human recombinant ERG by Competitive binding assay,C[C@@H]1CCCN1CCc1ccc(-c2ccc(S(=O)(=O)NC3CCC3)cc2)cc1,Bioorg Med Chem Lett,CHEMBL563118,0.75,Yes,6.124938737
CHEMBL1827362,Displacement of [3H]dofetilide from human recombinant ERG by Competitive binding assay,Nc1cc(CN2CCC(N(C(=O)NCc3ccc(F)cc3)c3ccc(Cl)cc3)CC2)ccn1,Bioorg Med Chem Lett,CHEMBL1091836,0.384,Yes,6.415668776
CHEMBL1827362,Displacement of [3H]dofetilide from human recombinant ERG by Competitive binding assay,O=C(Nc1ccccc1)N(c1ccc(Br)cc1)C1CCN(C2CCCC2)CC1,Bioorg Med Chem Lett,CHEMBL1094029,0.188,Yes,6.725842151
CHEMBL1827362,Displacement of [3H]dofetilide from human recombinant ERG by Competitive binding assay,O=C(NCc1ccc(F)cc1)N(c1ccc(Br)cc1)C1CCN(C2CCCC2)CC1,Bioorg Med Chem Lett,CHEMBL1094030,0.202,Yes,6.694648631
CHEMBL1827362,Displacement of [3H]dofetilide from human recombinant ERG by Competitive binding assay,O=C(NCc1ccccc1)N(c1ccc(Br)cc1)C1CCN(C2CCCC2)CC1,Bioorg Med Chem Lett,CHEMBL1094028,0.178,Yes,6.749579998
CHEMBL1827362,Displacement of [3H]dofetilide from human recombinant ERG by Competitive binding assay,C[C@@H]1CCCN1CCc1ccc2nc(-c3cnc4c(c3)OCO4)ccc2c1,Bioorg Med Chem Lett,CHEMBL1086074,40,No,4.397940009
CHEMBL1827362,Displacement of [3H]dofetilide from human recombinant ERG by Competitive binding assay,Cc1nc2ncccc2cc1-c1ccc2cc(CCN3CCC[C@H]3C)ccc2n1,Bioorg Med Chem Lett,CHEMBL263101,40,No,4.397940009
CHEMBL1827362,Displacement of [3H]dofetilide from human recombinant ERG by Competitive binding assay,C[C@@H]1CCCN1CCc1ccc2nc(-c3cn4c(n3)SCC4)ccc2c1,Bioorg Med Chem Lett,CHEMBL1084384,40,No,4.397940009
CHEMBL1827362,Displacement of [3H]dofetilide from human recombinant ERG by Competitive binding assay,Cc1nc(-c2cnccn2)sc1-c1ccc2cc(CCN3CCC[C@H]3C)ccc2n1,Bioorg Med Chem Lett,CHEMBL1085592,32,No,4.494850022
CHEMBL1827362,Displacement of [3H]dofetilide from human recombinant ERG by Competitive binding assay,Cc1cc(-c2ccc3cc(CCN4CCC[C@H]4C)ccc3n2)nc(-c2ccccc2)n1,Bioorg Med Chem Lett,CHEMBL1082488,0.12,Yes,6.920818754
CHEMBL1827362,Displacement of [3H]dofetilide from human recombinant ERG by Competitive binding assay,C[C@@H]1CCCN1CCc1ccc2nc(-c3cncnc3)ccc2c1,Bioorg Med Chem Lett,CHEMBL1085828,40,No,4.397940009
CHEMBL1827362,Displacement of [3H]dofetilide from human recombinant ERG by Competitive binding assay,Cc1n[nH]c(C)c1-c1ccc2cc(CCN3CCC[C@H]3C)ccc2n1,Bioorg Med Chem Lett,CHEMBL1084826,40,No,4.397940009
CHEMBL1827362,Displacement of [3H]dofetilide from human recombinant ERG by Competitive binding assay,Cc1c(-c2ccc3cc(CCN4CCC[C@H]4C)ccc3n2)cnn1C,Bioorg Med Chem Lett,CHEMBL1084827,40,No,4.397940009
CHEMBL1827362,Displacement of [3H]dofetilide from human recombinant ERG by Competitive binding assay,C[C@@H]1CCCN1CCc1ccc2nc(-c3cn[nH]c3)ccc2c1,Bioorg Med Chem Lett,CHEMBL1084582,40,No,4.397940009
CHEMBL1827362,Displacement of [3H]dofetilide from human recombinant ERG by Competitive binding assay,C[C@@H]1CCCN1CCc1ccc2nc(-c3ccn[nH]3)ccc2c1,Bioorg Med Chem Lett,CHEMBL1084581,40,No,4.397940009
CHEMBL1827362,Displacement of [3H]dofetilide from human recombinant ERG by Competitive binding assay,C[C@@H]1CCCN1CCc1ccc2nc(-c3cc(Br)no3)ccc2c1,Bioorg Med Chem Lett,CHEMBL1086520,0.88,Yes,6.055517328
CHEMBL1827362,Displacement of [3H]dofetilide from human recombinant ERG by Competitive binding assay,Cc1nc(C)c(-c2ccc3cc(CCN4CCC[C@H]4C)ccc3n2)o1,Bioorg Med Chem Lett,CHEMBL1083274,40,No,4.397940009
CHEMBL1827362,Displacement of [3H]dofetilide from human recombinant ERG by Competitive binding assay,Cc1c(-c2ccc3cc(CCN4CCC[C@H]4C)ccc3n2)cnn1-c1ccc(Cl)c(Cl)c1,Bioorg Med Chem Lett,CHEMBL1083463,0.6,Yes,6.22184875
CHEMBL1827362,Displacement of [3H]dofetilide from human recombinant ERG by Competitive binding assay,C[C@@H]1CCCN1CCc1ccc2nc(-c3c(O)ccnc3C(F)(F)F)ccc2c1,Bioorg Med Chem Lett,CHEMBL1085783,40,No,4.397940009
CHEMBL1827362,Displacement of [3H]dofetilide from human recombinant ERG by Competitive binding assay,Cc1nc(C)c(-c2ccc3cc(CCN4CCCC4C)ccc3n2)cc1C(N)=O,Bioorg Med Chem Lett,CHEMBL1822864,40,No,4.397940009
CHEMBL1827362,Displacement of [3H]dofetilide from human recombinant ERG by Competitive binding assay,C[C@@H]1CCCN1CCc1ccc2nc(C3CC3)ccc2c1,Bioorg Med Chem Lett,CHEMBL1086034,44,No,4.356547324
CHEMBL1827362,Displacement of [3H]dofetilide from human recombinant ERG by Competitive binding assay,Cc1ccc2cc(CCN3CCC[C@H]3C)ccc2n1,Bioorg Med Chem Lett,CHEMBL1086033,216,No,3.665546249
CHEMBL1827362,Displacement of [3H]dofetilide from human recombinant ERG by Competitive binding assay,C[C@@H]1CCCN1CCc1ccc2ncccc2c1,Bioorg Med Chem Lett,CHEMBL1086032,40,No,4.397940009
CHEMBL1826877,Inhibition of human ERG by electrophysiological assay,CC(=O)c1ccc2c(c1)N(CCN1CCC(NCc3ccc4c(n3)NC(=O)CO4)CC1)C(=O)CO2,Bioorg Med Chem Lett,CHEMBL1824040,49.1,No,4.308918508
CHEMBL1826877,Inhibition of human ERG by electrophysiological assay,CS(=O)(=O)c1ccc2c(c1)N(CCN1CCC(NCc3ccc4c(n3)NC(=O)CO4)CC1)C(=O)CO2,Bioorg Med Chem Lett,CHEMBL1824036,50.7,No,4.294992041
CHEMBL1831776,Inhibition of human ERG,c1ccc(Nc2nc(-c3cn[nH]c3)cs2)nc1,J Med Chem,CHEMBL1830693,33,No,4.48148606
CHEMBL1831617,Displacement of [3H]astemizole from human ERG expressed in HEK293 cells after 1 hr,O=C(CNC(=O)c1cccc(C(F)(F)F)c1)NC1CN([C@H]2CC[C@](O)(c3cccnc3)CC2)C1,Bioorg Med Chem Lett,CHEMBL1829603,35,No,4.455931956
CHEMBL1831617,Displacement of [3H]astemizole from human ERG expressed in HEK293 cells after 1 hr,Nc1ccc([C@H]2CC[C@H](N3CC(NC(=O)CNC(=O)c4cccc(C(F)(F)F)c4)C3)CC2)nc1,Bioorg Med Chem Lett,CHEMBL1829627,37,No,4.431798276
CHEMBL1831617,Displacement of [3H]astemizole from human ERG expressed in HEK293 cells after 1 hr,Nc1cccnc1[C@H]1CC[C@H](N2CC(NC(=O)CNC(=O)c3cccc(C(F)(F)F)c3)C2)CC1,Bioorg Med Chem Lett,CHEMBL1829626,44,No,4.356547324
CHEMBL1837361,Displacement of [3H]dofetilide from human ERG transfected in HEK293 cells by fluorescence polarization binding assay,COC(=O)N1Cc2cc(Cl)ccc2-n2c(nnc2C2CCN(c3ccccn3)CC2)C1,Bioorg Med Chem Lett,CHEMBL1837038,47.3,No,4.325138859
CHEMBL1837361,Displacement of [3H]dofetilide from human ERG transfected in HEK293 cells by fluorescence polarization binding assay,CC(=O)N1Cc2cc(Cl)ccc2-n2c(nnc2C2CCN(c3ccccn3)CC2)C1,Bioorg Med Chem Lett,CHEMBL1837040,35.2,No,4.453457337
CHEMBL1837361,Displacement of [3H]dofetilide from human ERG transfected in HEK293 cells by fluorescence polarization binding assay,CS(=O)(=O)N1Cc2cc(Cl)ccc2-n2c(nnc2C2CCN(c3ccccn3)CC2)C1,Bioorg Med Chem Lett,CHEMBL1837041,30.7,No,4.512861625
CHEMBL1837909,Displacement of [3H]-astemizole from human ERG in HEK293 cells after 1 hrs by scintillation counting,O=C(CNc1noc2ccc(C(F)(F)F)cc12)NC1CN([C@H]2CC[C@@H](c3nccs3)CC2)C1,Bioorg Med Chem Lett,CHEMBL1834854,0.011,Yes,7.958607315
CHEMBL1837909,Displacement of [3H]-astemizole from human ERG in HEK293 cells after 1 hrs by scintillation counting,O=C(CNc1noc2ccc(C(F)(F)F)cc12)NC1CN([C@H]2CC[C@@H](c3cncs3)CC2)C1,Bioorg Med Chem Lett,CHEMBL1834853,0.016,Yes,7.795880017
CHEMBL1837909,Displacement of [3H]-astemizole from human ERG in HEK293 cells after 1 hrs by scintillation counting,COc1ccc([C@H]2CC[C@@H](N3CC(NC(=O)CNc4noc5ccc(C(F)(F)F)cc45)C3)CC2)cn1,Bioorg Med Chem Lett,CHEMBL1834852,0.0087,Yes,8.060480747
CHEMBL1837909,Displacement of [3H]-astemizole from human ERG in HEK293 cells after 1 hrs by scintillation counting,NC(=O)n1nc(NCC(=O)NC2CN([C@H]3CC[C@@H](c4nccs4)CC3)C2)c2cc(C(F)(F)F)ccc21,Bioorg Med Chem Lett,CHEMBL1834795,31,No,4.508638306
CHEMBL1837909,Displacement of [3H]-astemizole from human ERG in HEK293 cells after 1 hrs by scintillation counting,Cn1nc(NCC(=O)NC2CN([C@H]3CC[C@@H](c4cncs4)CC3)C2)c2cc(C(F)(F)F)ccc21,Bioorg Med Chem Lett,CHEMBL1834793,44,No,4.356547324
CHEMBL1837909,Displacement of [3H]-astemizole from human ERG in HEK293 cells after 1 hrs by scintillation counting,COc1ccc([C@]2(O)CC[C@H](N3CC(NC(=O)CNc4n[nH]c5ccc(C(F)(F)F)cc45)C3)CC2)cn1,Bioorg Med Chem Lett,CHEMBL2092884,32,No,4.494850022
CHEMBL1837909,Displacement of [3H]-astemizole from human ERG in HEK293 cells after 1 hrs by scintillation counting,O=C(CNc1n[nH]c2ccc(C(F)(F)F)cc12)NC1CN([C@H]2CC[C@@H](c3cccnc3)CC2)C1,Bioorg Med Chem Lett,CHEMBL1834787,36,No,4.443697499
CHEMBL1837909,Displacement of [3H]-astemizole from human ERG in HEK293 cells after 1 hrs by scintillation counting,Cn1nc(NCC(=O)NC2CN([C@H]3CC[C@@H](CO)CC3)C2)c2cc(C(F)(F)F)ccc21,Bioorg Med Chem Lett,CHEMBL1834643,32,No,4.494850022
CHEMBL1837909,Displacement of [3H]-astemizole from human ERG in HEK293 cells after 1 hrs by scintillation counting,Cn1nc(NCC(=O)NC2CN([C@H]3CC[C@@H](C(N)=O)CC3)C2)c2cc(C(F)(F)F)ccc21,Bioorg Med Chem Lett,CHEMBL1834642,32,No,4.494850022
CHEMBL1837909,Displacement of [3H]-astemizole from human ERG in HEK293 cells after 1 hrs by scintillation counting,O=C(CNc1n[nH]c2ccc(C(F)(F)F)cc12)NC1CN([C@H]2CC[C@@H](n3ccccc3=O)CC2)C1,Bioorg Med Chem Lett,CHEMBL1834636,34,No,4.468521083
CHEMBL1837909,Displacement of [3H]-astemizole from human ERG in HEK293 cells after 1 hrs by scintillation counting,Cn1nc(NCC(=O)NC2CN([C@H]3CC[C@@H](c4ccc5c(c4)OCO5)CC3)C2)c2cc(C(F)(F)F)ccc21,Bioorg Med Chem Lett,CHEMBL1834635,0.84,Yes,6.075720714
CHEMBL1838283,Inhibition of human ERG expressed in CHO-K1 cells after 2 hrs by Cy3b-Dofetilide-based fluorescence polarisation assay,Cc1cccc(Nc2nc(N[C@@H]3CCNC3)ncc2C(N)=O)c1,Bioorg Med Chem Lett,CHEMBL1835057,0.50119,Yes,6.299997603
CHEMBL1838283,Inhibition of human ERG expressed in CHO-K1 cells after 2 hrs by Cy3b-Dofetilide-based fluorescence polarisation assay,NC(=O)c1cnc(N2CCC[C@H](N)C2)nc1Nc1cccc(C(F)(F)F)c1,Bioorg Med Chem Lett,CHEMBL1835063,0.79433,Yes,6.099999035
CHEMBL1839504,Inhibition of human ERG by patch clamp assay,COc1cc(OC)cc(C(=O)NCC2(C#N)CCN(Cc3ccccc3OC)CC2)c1,Bioorg Med Chem Lett,CHEMBL1836146,0.92,Yes,6.036212173
CHEMBL1839504,Inhibition of human ERG by patch clamp assay,N#CC1(CNC(=O)c2cc(Cl)cc(Cl)c2)CCN(CCc2ccccc2)CC1,Bioorg Med Chem Lett,CHEMBL1836161,0.36,Yes,6.443697499
CHEMBL1839504,Inhibition of human ERG by patch clamp assay,COC(=O)C1(CNC(=O)c2cc(OC)cc(OC)c2)CCN(Cc2cccc(OC)c2)CC1,Bioorg Med Chem Lett,CHEMBL1836163,0.31,Yes,6.508638306
CHEMBL1839504,Inhibition of human ERG by patch clamp assay,COC(=O)C1(CNC(=O)c2cc(OC)cc(OC)c2)CCN(Cc2ccc(OC)cc2)CC1,Bioorg Med Chem Lett,CHEMBL1836164,0.48,Yes,6.318758763
CHEMBL1839504,Inhibition of human ERG by patch clamp assay,COC(=O)C1(CNC(=O)c2cc(Cl)cc(Cl)c2)CCN(Cc2ccccc2OC)CC1,Bioorg Med Chem Lett,CHEMBL1836247,0.16,Yes,6.795880017
CHEMBL1839504,Inhibition of human ERG by patch clamp assay,COC(=O)C1(CNC(=O)c2cc(Cl)cc(Cl)c2)CCN(Cc2cccc(OC)c2)CC1,Bioorg Med Chem Lett,CHEMBL1836248,0.36,Yes,6.443697499
CHEMBL1839504,Inhibition of human ERG by patch clamp assay,COC(=O)C1(CNC(=O)c2cc(Cl)cc(Cl)c2)CCN(Cc2ccc(OC)cc2)CC1,Bioorg Med Chem Lett,CHEMBL1836249,0.13,Yes,6.886056648
CHEMBL1839504,Inhibition of human ERG by patch clamp assay,COC(=O)C1(CNC(=O)c2cc(Cl)cc(Cl)c2)CCN(Cc2ccccc2C(F)(F)F)CC1,Bioorg Med Chem Lett,CHEMBL1836250,0.46,Yes,6.337242168
CHEMBL1839504,Inhibition of human ERG by patch clamp assay,COC(=O)C1(CNC(=O)c2cc(Cl)cc(Cl)c2)CCN(Cc2cccc(C(F)(F)F)c2)CC1,Bioorg Med Chem Lett,CHEMBL1836251,0.89,Yes,6.050609993
CHEMBL1839504,Inhibition of human ERG by patch clamp assay,COC(=O)C1(CNC(=O)c2cc(Cl)cc(Cl)c2)CCN(Cc2ccc(C(F)(F)F)cc2)CC1,Bioorg Med Chem Lett,CHEMBL1836252,0.29,Yes,6.537602002
CHEMBL1839504,Inhibition of human ERG by patch clamp assay,COc1ccccc1CN1CCC(C#N)(CNC(=O)c2cc(CC(C)C)n(-c3ccccc3)n2)CC1,Bioorg Med Chem Lett,CHEMBL1836255,0.92,Yes,6.036212173
CHEMBL1839633,Inhibition of human ERG,Cc1nc2ccccc2n1-c1ccc(C(=O)N(C)[C@@H]2CCN(C(C)C)C2)cc1,Bioorg Med Chem Lett,CHEMBL1836035,45,No,4.346787486
CHEMBL1840125,Inhibition of human hERG,NC(=O)c1cnc(N[C@H](C2CC2)C(F)(F)F)c2c1[nH]c1cc(-c3ccc(N)nc3)ccc12,J Med Chem,CHEMBL1835150,0.75,Yes,6.124938737
CHEMBL1840125,Inhibition of human hERG,NC(=O)c1cnc(NC(C2CC2)C2CC2)c2c1[nH]c1cc(-c3cnc(N)cn3)ccc12,J Med Chem,CHEMBL1835148,0.72,Yes,6.142667504
CHEMBL1840125,Inhibition of human hERG,NC(=O)c1cnc(NC(C2CC2)C2CC2)c2c1[nH]c1cc(-c3cn[nH]c3)ccc12,J Med Chem,CHEMBL1835146,0.99,Yes,6.004364805
CHEMBL1840125,Inhibition of human hERG,Cn1cc(-c2ccc3c(c2)[nH]c2c(C(N)=O)ccc(NC4CCCCC4)c23)cn1,J Med Chem,CHEMBL1835035,0.62,Yes,6.207608311
CHEMBL1909190,DRUGMATRIX: Potassium Channel HERG radioligand binding (ligand: [3H] Astemizole),CC(C)(C)CC(C)(C)c1ccc(OCCOCC[N+](C)(C)Cc2ccccc2)cc1.[Cl-],,CHEMBL221753,0.1085,Yes,6.964570262
CHEMBL1909190,DRUGMATRIX: Potassium Channel HERG radioligand binding (ligand: [3H] Astemizole),CC(C)(C)c1ccc(C(=O)CCCN2CCC(OC(c3ccccc3)c3ccccc3)CC2)cc1,,CHEMBL305660,0.1048,Yes,6.979638717
CHEMBL1909190,DRUGMATRIX: Potassium Channel HERG radioligand binding (ligand: [3H] Astemizole),Fc1ccc(C(c2ccc(F)cc2)N2CCN(C/C=C/c3ccccc3)CC2)cc1,,CHEMBL30008,0.6058,Yes,6.217670731
CHEMBL1909190,DRUGMATRIX: Potassium Channel HERG radioligand binding (ligand: [3H] Astemizole),O=C(CCCN1CC=C(n2c(=O)[nH]c3ccccc32)CC1)c1ccc(F)cc1,,CHEMBL1108,0.9272,Yes,6.032826577
CHEMBL1909190,DRUGMATRIX: Potassium Channel HERG radioligand binding (ligand: [3H] Astemizole),CN(C)CCOC(c1ccccc1)c1ccccc1,,CHEMBL657,31.859,No,4.49676786
CHEMBL1909190,DRUGMATRIX: Potassium Channel HERG radioligand binding (ligand: [3H] Astemizole),CN1CCC[C@@H]1CCO[C@](C)(c1ccccc1)c1ccc(Cl)cc1,,CHEMBL1626,0.3951,Yes,6.40329297
CHEMBL1909190,DRUGMATRIX: Potassium Channel HERG radioligand binding (ligand: [3H] Astemizole),COc1cc(N)c(Cl)cc1C(=O)NC1CCN(CCCOc2ccc(F)cc2)CC1OC,,CHEMBL1729,0.1701,Yes,6.769295686
CHEMBL1909190,DRUGMATRIX: Potassium Channel HERG radioligand binding (ligand: [3H] Astemizole),Cc1cc2c(s1)Nc1ccccc1N=C2N1CCN(C)CC1,,CHEMBL715,100,No,4
CHEMBL1909190,DRUGMATRIX: Potassium Channel HERG radioligand binding (ligand: [3H] Astemizole),CCOC(=O)N1CCC(=C2c3ccc(Cl)cc3CCc3cccnc32)CC1,,CHEMBL998,39.0866,No,4.407972106
CHEMBL1909190,DRUGMATRIX: Potassium Channel HERG radioligand binding (ligand: [3H] Astemizole),CC/C(=C(\c1ccccc1)c1ccc(OCCN(C)C)cc1)c1ccccc1,,CHEMBL83,0.967,Yes,6.014573526
CHEMBL1909190,DRUGMATRIX: Potassium Channel HERG radioligand binding (ligand: [3H] Astemizole),C[C@@H]1CN(c2c(F)c(N)c3c(=O)c(C(=O)O)cn(C4CC4)c3c2F)C[C@H](C)N1,,CHEMBL850,47.1384,No,4.326625163
CHEMBL1913194,Inhibition of human ERG,Cc1nc2c(c(-c3ccc(Cl)cc3Cl)c1CN)CN(CC(=O)NCc1cccnc1)C2=O,Bioorg Med Chem Lett,CHEMBL1910126,80,No,4.096910013
CHEMBL1919743,Inhibition of human ERG by ionworks HT assay,COc1ccc2ccc(=O)n(CCN3CCC(NCc4cc5c(cn4)OCCO5)CC3)c2n1,J Med Chem,CHEMBL1916545,40,No,4.397940009
CHEMBL1919743,Inhibition of human ERG by ionworks HT assay,COc1ncc2ncc(=O)n(CCN3CCC(NCc4cc5c(cn4)OCCO5)CC3)c2n1,J Med Chem,CHEMBL1916544,81,No,4.091514981
CHEMBL1919743,Inhibition of human ERG by ionworks HT assay,COc1ncc2ccc(=O)n(CCN3CCC(NCc4cc5c(cn4)OCCO5)CC3)c2n1,J Med Chem,CHEMBL1916543,206,No,3.68613278
CHEMBL1919743,Inhibition of human ERG by ionworks HT assay,COc1ccc2ncc(=O)n(CCN3CCC(NCc4cc5c(cn4)OCCO5)CC3)c2n1,J Med Chem,CHEMBL1914480,31,No,4.508638306
CHEMBL1919743,Inhibition of human ERG by ionworks HT assay,COc1ccc2ccc(=O)n(CCN3CCC(NCc4cc5c(cn4)OCCO5)CC3)c2c1,J Med Chem,CHEMBL1916539,34,No,4.468521083
CHEMBL1919743,Inhibition of human ERG by ionworks HT assay,COc1ccc2c(c1)N(CCN1CCC(NCc3ccc4c(n3)NC(=O)CO4)CC1)C(=O)OC2,J Med Chem,CHEMBL1916538,42,No,4.37675071
CHEMBL1919743,Inhibition of human ERG by ionworks HT assay,N#Cc1ccc2c(c1)N(CCN1CCC(NCc3ccc4c(n3)NC(=O)CO4)CC1)C(=O)CO2,J Med Chem,CHEMBL1824041,41,No,4.387216143
CHEMBL1932121,Inhibition of human ERG by whole cell patch clamp assay,COc1ccc2nccc(NC(=O)[C@]3(O)CC[C@@H](NCc4cnc5c(c4)OCCO5)CC3)c2n1,Bioorg Med Chem Lett,CHEMBL1926766,52,No,4.283996656
CHEMBL1932121,Inhibition of human ERG by whole cell patch clamp assay,COc1cc(F)c2nccc(NC(=O)[C@]3(O)CC[C@@H](NCc4cc5c(cn4)OCCO5)CC3)c2c1,Bioorg Med Chem Lett,CHEMBL1926865,113,No,3.946921557
CHEMBL1932121,Inhibition of human ERG by whole cell patch clamp assay,COc1ccc2nccc(NC(=O)[C@]3(O)CC[C@@H](NCc4cc5c(cn4)OCCO5)CC3)c2c1,Bioorg Med Chem Lett,CHEMBL1926866,200,No,3.698970004
CHEMBL1930402,Inhibition of human ERG,COc1ccc(N(Cc2cnccc2C)C2CCN([C@H](C)CCNC(=O)c3c(C)cc(Cl)nc3C)CC2)cc1,Bioorg Med Chem Lett,CHEMBL1926893,0.25,Yes,6.602059991
CHEMBL1931724,Displacement of [3H]dofetilide from human ERG by liquid scintillation counting,COc1ccc2nccc([C@@H](O)CN3CCC(NCc4ccc5c(c4)OCCO5)CC3)c2c1,Bioorg Med Chem Lett,CHEMBL548279,39.8,No,4.400116928
CHEMBL1931724,Displacement of [3H]dofetilide from human ERG by liquid scintillation counting,COc1ccc2ncc(F)c([C@@H](O)CN3CCC(NCc4cc5c(cn4)OCCO5)CC3)c2n1,Bioorg Med Chem Lett,CHEMBL1927165,79.4,No,4.100179498
CHEMBL1931724,Displacement of [3H]dofetilide from human ERG by liquid scintillation counting,COc1ccc2ncc(F)c([C@H](O)CN3CCC(NCc4cc5c(cn4)OCCO5)CC3)c2n1,Bioorg Med Chem Lett,CHEMBL1927166,63.1,No,4.199970641
CHEMBL1931724,Displacement of [3H]dofetilide from human ERG by liquid scintillation counting,COc1ccc2ncc(C#N)c(CCN3CCC(NCc4cc5c(cn4)OCS5)CC3)c2c1,Bioorg Med Chem Lett,CHEMBL1235773,0.5,Yes,6.301029996
CHEMBL1938199,Inhibition of human Erg by whole cell patch clamp electrophysiology,CN1CCC[C@@H](c2nc3ccccc3n2Cc2ccc(F)cc2)C1,Bioorg Med Chem Lett,CHEMBL1095819,0.72,Yes,6.142667504
CHEMBL1938199,Inhibition of human Erg by whole cell patch clamp electrophysiology,CN(C)C(=O)CN1CCCC(c2nc3ccccc3n2CCOc2ccccc2)C1,Bioorg Med Chem Lett,CHEMBL1935439,0.45,Yes,6.346787486
CHEMBL1938199,Inhibition of human Erg by whole cell patch clamp electrophysiology,Cc1ccc(Cn2c(C3CNCCS3)nc3ccccc32)cc1,Bioorg Med Chem Lett,CHEMBL1935444,0.93,Yes,6.031517051
CHEMBL1938199,Inhibition of human Erg by whole cell patch clamp electrophysiology,Fc1ccc(Cn2c([C@H]3CNCCS3)nc3ccccc32)cc1,Bioorg Med Chem Lett,CHEMBL1935446,0.9,Yes,6.045757491
CHEMBL1938199,Inhibition of human Erg by whole cell patch clamp electrophysiology,CN(CC1CCOCC1)C1CCN(c2nc3ccccc3n2Cc2ccc(F)cc2)CC1,Bioorg Med Chem Lett,CHEMBL550818,0.029,Yes,7.537602002
CHEMBL1938199,Inhibition of human Erg by whole cell patch clamp electrophysiology,Cc1cnn(C2CCN(c3nc4ccccc4n3Cc3ccc(F)cc3)CC2)c1,Bioorg Med Chem Lett,CHEMBL556450,0.809,Yes,6.092051478
CHEMBL1943689,Inhibition of human ERG,COc1cc2ncnc(Oc3ccc(CC(=O)Nc4cnn(C(C)C)c4)cc3)c2cc1OC,Bioorg Med Chem Lett,CHEMBL1940274,137,No,3.863279433
CHEMBL1947877,Inhibition of human ERG,CCN(CC)C(=O)c1ccc(C(=C2CCN(Cc3ccc(F)cc3)CC2)c2ccc(NC(=O)OC)cc2)cc1,Bioorg Med Chem Lett,CHEMBL1946024,0.9,Yes,6.045757491
CHEMBL1947877,Inhibition of human ERG,CCN(CC)C(=O)c1ccc(C(=C2CCNCC2)c2ccccn2)cc1,Bioorg Med Chem Lett,CHEMBL1946619,33,No,4.48148606
CHEMBL1947996,Binding affinity to human ERG channel,C[N+](C)(CCCCNC(=O)Cc1ccc(OCc2ccccc2)cc1)CCNC(=O)c1nc(Cl)c(N)nc1N.[Br-],Bioorg Med Chem Lett,CHEMBL1945199,0.33,Yes,6.48148606
CHEMBL1954142,Inhibition of human ERG by cell based voltage clamp assay,COc1cc(/C=C2\CCCN3C2=NOC3(C)c2ccc(F)cc2)ccc1-n1cnc(C)c1,J Med Chem,CHEMBL1950433,0.74,Yes,6.13076828
CHEMBL1954529,"Displacement of 3,7-Bis[2-(4-nitro[3,5-3H]phenyl)ethyl]-3,7-diazabicyclo[3.3.1]nonane from human ERG expressed in HEK cells after 3 hrs",CCN(C(=O)Cc1ccc(S(C)(=O)=O)cc1)C1CCN(CC[C@@H](c2cccc(OC)c2)C2CCN(S(C)(=O)=O)CC2)CC1,Bioorg Med Chem Lett,CHEMBL1951911,32,No,4.494850022
CHEMBL1954529,"Displacement of 3,7-Bis[2-(4-nitro[3,5-3H]phenyl)ethyl]-3,7-diazabicyclo[3.3.1]nonane from human ERG expressed in HEK cells after 3 hrs",CCN(C(=O)Cc1ccc(S(C)(=O)=O)cc1)C1CCN(CC[C@@H](c2cccc(F)c2)C2CCN(S(C)(=O)=O)CC2)CC1,Bioorg Med Chem Lett,CHEMBL1951912,35,No,4.455931956
CHEMBL1954009,Inhibition of human Erg by patch clamp assay,COc1ccc([C@]2(O)CC[C@H](N3CC[C@@H](NC(=O)CNC(=O)c4cccc(C(F)(F)F)c4)C3)CC2)cn1.CS(=O)(=O)O,ACS Med Chem Lett,CHEMBL1951778,84,No,4.075720714
CHEMBL1954401,Inhibition of human ERG by dofetilide binding assay,COc1cccc(C(=O)Cn2c(=O)c3c(c(C#N)c(N4CCC[C@H](N)C4)n3Cc3ccccc3)n(C)c2=O)c1,Bioorg Med Chem Lett,CHEMBL1951595,0.1,Yes,7
CHEMBL1954401,Inhibition of human ERG by dofetilide binding assay,CC(C)=CCn1c(N2CCCNCC2)c(C#N)c2c1c(=O)n(Cc1c(C#N)cnc3ccccc13)c(=O)n2C,Bioorg Med Chem Lett,CHEMBL1949693,0.9,Yes,6.045757491
CHEMBL1954570,Displacement of [3H]astemizole from human ERG expressed in CHO-K1 cell membranes,COc1cc(NCC2CCNCC2)nc2c1nnn2-c1cccc(N(C)C)c1,Bioorg Med Chem Lett,CHEMBL1952143,31.62278,No,4.499999953
CHEMBL1954570,Displacement of [3H]astemizole from human ERG expressed in CHO-K1 cell membranes,FC(F)(F)Oc1cccc(-n2nnc3cc(Cl)c(NCC4CCNCC4)nc32)c1,Bioorg Med Chem Lett,CHEMBL1952144,0.39811,Yes,6.399996913
CHEMBL1954249,Inhibition of human ERG,O=C(N1CCCCC1)N1CC(O[C@@H](c2ccc(Cl)cc2)c2cccnc2Cl)C1,Bioorg Med Chem Lett,CHEMBL555563,30.8,No,4.511449283
CHEMBL1960000,Displacement of [3H]-astemizole from human ERG expressed in CHO-K1 cells membrane,CS(=O)(=O)N1CCN(Cc2cn3cc(-c4cccc5[nH]ncc45)nc(N4CCOCC4)c3n2)CC1,Bioorg Med Chem Lett,CHEMBL1957497,100,No,4
CHEMBL1960000,Displacement of [3H]-astemizole from human ERG expressed in CHO-K1 cells membrane,CS(=O)(=O)N1CCN(Cc2cc3nc(-c4cccc5[nH]ncc45)nc(N4CCOCC4)c3s2)CC1,Bioorg Med Chem Lett,CHEMBL521851,64,No,4.193820026
CHEMBL1961077,Inhibition of human ERG,CC(=O)NCCc1ccccc1-c1ccc([C@@H](CN)Cc2ccc(OCCOc3c(Cl)cc(C)cc3Cl)cc2)c(C)c1.Cl,Bioorg Med Chem Lett,CHEMBL1957798,0.006,Yes,8.22184875
CHEMBL1958785,Inhibition of human Erg by patch clamp assay,Cc1nc2cnc(Oc3ccc(Cl)cc3F)cc2c(=O)n1C[C@H]1CCCN(C(C)C)C1,Bioorg Med Chem Lett,CHEMBL1956999,0.13,Yes,6.886056648
CHEMBL1958785,Inhibition of human Erg by patch clamp assay,Cc1nc2cnc(Oc3ccc(Cl)cc3F)cc2c(=O)n1C[C@H]1CCCN(C(C)C)C1,Bioorg Med Chem Lett,CHEMBL1956999,0.12882,Yes,6.890016705
CHEMBL1958785,Inhibition of human Erg by patch clamp assay,Cc1nc2ncc(Oc3ccc(Cl)cc3F)nc2c(=O)n1C[C@H]1CCCN(C(C)C)C1,Bioorg Med Chem Lett,CHEMBL1957005,33.11311,No,4.480000028
CHEMBL1958785,Inhibition of human Erg by patch clamp assay,Cc1nc2ncc(Oc3ccc(F)c4cccnc34)nc2c(=O)n1C[C@H]1CCCN(C(C)C)C1,Bioorg Med Chem Lett,CHEMBL1957008,33.11311,No,4.480000028
CHEMBL1958785,Inhibition of human Erg by patch clamp assay,Cc1nc2ccc(Oc3ccc(F)c4cccnc34)nc2c(=O)n1C[C@H]1CCCN(C(C)C)C1,Bioorg Med Chem Lett,CHEMBL1956996,0.12999,Yes,6.886090056
CHEMBL2013640,Inhibition of human ERG by patchXpress assay,c1ccc(Cn2ccc3c(OC4CCN(Cc5cscn5)CC4)ncnc32)cc1,Bioorg Med Chem Lett,CHEMBL2012244,0.76,Yes,6.119186408
CHEMBL2013640,Inhibition of human ERG by patchXpress assay,Cc1c(C)n(Cc2ccccc2)c2ncnc(OC3CCN(Cc4cscn4)CC3)c12,Bioorg Med Chem Lett,CHEMBL2012178,0.51,Yes,6.292429824
CHEMBL2014814,Inhibition of human ERG expressed in CHOK1 cells by whole cell voltage clamp assay,Cc1nc2c(C#N)cccc2n1-c1ccc(C(=O)NC2CC2)s1,ACS Med Chem Lett,CHEMBL2012958,53,No,4.27572413
CHEMBL2013523,Inhibition of human ERG by fluorescence polarization assay,CCC(NCCCC[C@@H](Nc1cc(C)c(F)c(C)c1)C(=O)NO)c1ccc(F)cc1,Bioorg Med Chem Lett,CHEMBL2012836,0.95,Yes,6.022276395
CHEMBL2013523,Inhibition of human ERG by fluorescence polarization assay,Cc1cc(O[C@H](CCCCNCc2ccc(F)cc2)C(=O)NO)cc(C)c1F,Bioorg Med Chem Lett,CHEMBL1760322,0.79,Yes,6.102372909
CHEMBL2021018,Inhibition of human ERG,Cc1nc(N2CCC(N3CCCC3)CC2)nc2ccc(NC(=O)COc3ccc(Cl)cc3)cc12,Bioorg Med Chem Lett,CHEMBL2016731,0.45,Yes,6.346787486
CHEMBL2021104,Inhibition of human ERG,COc1cc(-c2cn(CC(=O)N(c3ccccc3)C3CCCCC3)nn2)ccc1-n1cnc(C)c1,Bioorg Med Chem Lett,CHEMBL2017409,0.8,Yes,6.096910013
CHEMBL2021104,Inhibition of human ERG,COc1cc(-c2cn(CC(=O)N(Cc3ccc(F)cc3)C3C4CC5CC(C4)CC3C5)nn2)ccc1-n1cnc(C)c1,Bioorg Med Chem Lett,CHEMBL2017413,0.25,Yes,6.602059991
CHEMBL2021104,Inhibition of human ERG,COc1cc(-c2cn(CC(=O)N(Cc3ccccc3)Cc3ccccc3)nn2)ccc1-n1cnc(C)c1,Bioorg Med Chem Lett,CHEMBL2017414,0.87,Yes,6.060480747
CHEMBL2021104,Inhibition of human ERG,COc1cc(-c2cn(CC(=O)N(Cc3ccccc3)[C@H](C)c3ccccc3)nn2)ccc1-n1cnc(C)c1,Bioorg Med Chem Lett,CHEMBL2017415,0.43,Yes,6.366531544
CHEMBL2021104,Inhibition of human ERG,COc1cc(-c2cn(CC(=O)N([C@H](C)c3ccccc3)[C@H](C)c3ccccc3)nn2)ccc1-n1cnc(C)c1,Bioorg Med Chem Lett,CHEMBL2017416,0.84,Yes,6.075720714
CHEMBL2021104,Inhibition of human ERG,COc1cc(-c2cn(CC(=O)N(CC(F)(F)F)c3ccc4ccccc4c3)nn2)ccc1-n1cnc(C)c1,Bioorg Med Chem Lett,CHEMBL2017566,0.63,Yes,6.200659451
CHEMBL2021104,Inhibition of human ERG,COc1cc(-c2cn(CC(=O)N(CC(F)(F)F)c3cccc4ccccc34)nn2)ccc1-n1cnc(C)c1,Bioorg Med Chem Lett,CHEMBL2017567,0.8,Yes,6.096910013
CHEMBL2021104,Inhibition of human ERG,COc1cc(-c2cn(C3CCCCNC3=O)nn2)ccc1-n1cnc(C)c1,Bioorg Med Chem Lett,CHEMBL2017568,43.9,No,4.35753548
CHEMBL2021104,Inhibition of human ERG,COc1cc(-c2cn(C3CCCC(C(C)(C)C)NC3=O)nn2)ccc1-n1cnc(C)c1,Bioorg Med Chem Lett,CHEMBL2016588,44.2,No,4.354577731
CHEMBL2021104,Inhibition of human ERG,COc1cc(-c2cn([C@H]3C[C@@H](C(C)(C)C)CCN(CC45CC6CC(CC(C6)C4)C5)C3=O)nn2)ccc1-n1cnc(C)c1,Bioorg Med Chem Lett,CHEMBL2017576,0.87,Yes,6.060480747
CHEMBL2021104,Inhibition of human ERG,COc1cc(-c2cn([C@H]3CC[C@H](c4ccccc4)CN(Cc4ccccc4)C3=O)nn2)ccc1-n1cnc(C)c1,Bioorg Med Chem Lett,CHEMBL2017579,0.2,Yes,6.698970004
CHEMBL2021104,Inhibition of human ERG,COc1cc(-c2cn([C@H]3C[C@@H]([Si](C)(C)C)CCN(Cc4ccccc4)C3=O)nn2)ccc1-n1cnc(C)c1,Bioorg Med Chem Lett,CHEMBL2017581,40.8,No,4.389339837
CHEMBL2021104,Inhibition of human ERG,COc1cc(-c2cn([C@H]3C[C@@H](C(F)(F)F)CCN(CC(F)(F)F)C3=O)nn2)ccc1-n1cnc(C)c1,Bioorg Med Chem Lett,CHEMBL2017582,31.9,No,4.496209317
CHEMBL2026445,Inhibition of human ERG,CCOc1cc2nccc(Oc3cnc(CC(=O)Nc4n[nH]c(CC)c4C)c(OC)c3)c2cc1OC,Bioorg Med Chem Lett,CHEMBL2023802,76,No,4.119186408
CHEMBL2024805,Displacement of [3H]Dofetilide from human ERG expressed in CHO-K1 cells by scintillation proximity assay,O=C(Nc1ccc(-c2nnc(NCCCN3CCOCC3)o2)cc1)c1ccccc1F,Bioorg Med Chem Lett,CHEMBL2022497,31.62278,No,4.499999953
CHEMBL2026860,Displacement of [3H]Dofetilide from human ERG expressed in CHO-K1 cells by scintillation proximity assay,O=C(Nc1ccc(-c2nnc(NCCCN3CCOCC3)o2)cc1)c1ccccc1F,Bioorg Med Chem Lett,CHEMBL2022497,31.62278,No,4.499999953
CHEMBL2026860,Displacement of [3H]Dofetilide from human ERG expressed in CHO-K1 cells by scintillation proximity assay,CN1CCN(CCCNc2nnc(-c3ccc(NC(=O)c4ccccc4F)cc3)o2)CC1,Bioorg Med Chem Lett,CHEMBL2022501,63.09573,No,4.200000031
CHEMBL2026860,Displacement of [3H]Dofetilide from human ERG expressed in CHO-K1 cells by scintillation proximity assay,O=C(Nc1ccc(-c2nnc(NCCCCN3CCOCC3)o2)cc1)c1ccccc1F,Bioorg Med Chem Lett,CHEMBL2022729,63.09573,No,4.200000031
CHEMBL2026860,Displacement of [3H]Dofetilide from human ERG expressed in CHO-K1 cells by scintillation proximity assay,O=C(Nc1ccc(-c2nnc(NCCCCN3CCOCC3)o2)c(F)c1)c1ccccc1F,Bioorg Med Chem Lett,CHEMBL2022739,39.81072,No,4.399999968
CHEMBL2026493,Displacement of [3H] dofetilide from human ERG channel expressed in HEK293 cells after 45 mins by scintillation counting method,NS(=O)(=O)c1ccc(OCCCN2CCCCC2)cc1,Eur J Med Chem,CHEMBL2024378,93.2,No,4.030584088
CHEMBL2026493,Displacement of [3H] dofetilide from human ERG channel expressed in HEK293 cells after 45 mins by scintillation counting method,CCOC(=O)C1CCN(CCCOc2ccc(S(N)(=O)=O)cc2)CC1,Eur J Med Chem,CHEMBL2024379,76.5,No,4.116338565
CHEMBL2026493,Displacement of [3H] dofetilide from human ERG channel expressed in HEK293 cells after 45 mins by scintillation counting method,CCOC(=O)C1CCN(CCCOc2ccc(S(=O)(=O)NC(=O)Nc3ccccc3)cc2)CC1,Eur J Med Chem,CHEMBL2021969,78.7,No,4.104025268
CHEMBL2026493,Displacement of [3H] dofetilide from human ERG channel expressed in HEK293 cells after 45 mins by scintillation counting method,O=C(Nc1ccc(C(F)(F)F)cc1)NS(=O)(=O)c1ccc(OCCCCN2CCCC2)cc1,Eur J Med Chem,CHEMBL2021974,49.1,No,4.308918508
CHEMBL2032591,Inhibition of human Erg expressed in HEK293 cells assessed as rubidium efflux after 4 hrs by atomic absorbance spectrometric analysis,C[C@H]1c2c([nH]c3ccc(C(F)(F)F)cc23)C[C@H]2CCN(CCCC3CCOCC3)C[C@@H]21,Bioorg Med Chem Lett,CHEMBL1922270,0.03,Yes,7.522878745
CHEMBL2032591,Inhibition of human Erg expressed in HEK293 cells assessed as rubidium efflux after 4 hrs by atomic absorbance spectrometric analysis,C[C@H]1c2c([nH]c3ccc(C(F)(F)F)cc23)C[C@H]2CCN(CCCC3(C(=O)O)CCOCC3)C[C@@H]21,Bioorg Med Chem Lett,CHEMBL2032047,0.3,Yes,6.522878745
CHEMBL2032591,Inhibition of human Erg expressed in HEK293 cells assessed as rubidium efflux after 4 hrs by atomic absorbance spectrometric analysis,CC(C)(C)c1ccc(C(O)CCCN2CCC(C(O)(c3ccccc3)c3ccccc3)CC2)cc1,Bioorg Med Chem Lett,CHEMBL17157,0.056,Yes,7.251811973
CHEMBL2034394,Inhibition of human ERG by IonWorks assay,CN(C)C(=O)c1ccc(-c2ccc3c(c2)CCN(CCN2CCCC2)C3=O)c(F)c1,J Med Chem,CHEMBL2031882,32.5,No,4.488116639
CHEMBL2034394,Inhibition of human ERG by IonWorks assay,C[C@@H]1CCCN1CCN1CCc2cc(-c3ccc(F)cc3)ccc2C1=O,J Med Chem,CHEMBL2031760,0.3,Yes,6.522878745
CHEMBL2034394,Inhibition of human ERG by IonWorks assay,C[C@@H]1CCCN1CCN1CCc2cc(-c3ccc(C#N)cc3)ccc2C1=O,J Med Chem,CHEMBL2031762,0.14,Yes,6.853871964
CHEMBL2032798,Inhibition of human ERG,CNC(=O)CCCN(C)C(=O)c1ccc2c(c1)c1c(n2C)CC[C@@H](C2CCOCC2)C1,Bioorg Med Chem Lett,CHEMBL2029729,105,No,3.978810701
CHEMBL2033832,Inhibition of human Erg expressed in HEK293 cells by whole cell patch clamp analysis,COc1cc(CN2CCN(CCCCCC(c3ccc(F)cc3)c3ccc(F)cc3)CC2)cc(OC)c1OC,Bioorg Med Chem Lett,CHEMBL2031958,0.4,Yes,6.397940009
CHEMBL2033832,Inhibition of human Erg expressed in HEK293 cells by whole cell patch clamp analysis,CC(C)(C)c1cc(CN2CCN(CCCCCC(c3ccc(F)cc3)c3ccc(F)cc3)CC2)cc(C(C)(C)C)c1O,Bioorg Med Chem Lett,CHEMBL2031961,0.1,Yes,7
CHEMBL2033832,Inhibition of human Erg expressed in HEK293 cells by whole cell patch clamp analysis,CC(C)(C)c1cc(C(=O)N2CCN(CCCCCC(c3ccc(F)cc3)c3ccc(F)cc3)CC2)cc(C(C)(C)C)c1O,Bioorg Med Chem Lett,CHEMBL2031962,0.25,Yes,6.602059991
CHEMBL2033832,Inhibition of human Erg expressed in HEK293 cells by whole cell patch clamp analysis,COc1c(C(C)(C)C)cc(CN2CCN(CCCCCC(c3ccc(F)cc3)c3ccc(F)cc3)CC2)cc1C(C)(C)C,Bioorg Med Chem Lett,CHEMBL2031965,0.1,Yes,7
CHEMBL2033832,Inhibition of human Erg expressed in HEK293 cells by whole cell patch clamp analysis,COc1c(C(C)(C)C)cc(C(=O)N2CCN(CCCCCC(c3ccc(F)cc3)c3ccc(F)cc3)CC2)cc1C(C)(C)C,Bioorg Med Chem Lett,CHEMBL2031966,0.66,Yes,6.180456064
CHEMBL2033832,Inhibition of human Erg expressed in HEK293 cells by whole cell patch clamp analysis,COc1c(C(C)(C)C)cc(CN2CCN(C(=O)CCCCC(c3ccc(F)cc3)c3ccc(F)cc3)CC2)cc1C(C)(C)C,Bioorg Med Chem Lett,CHEMBL2031967,0.13,Yes,6.886056648
CHEMBL2033832,Inhibition of human Erg expressed in HEK293 cells by whole cell patch clamp analysis,CC(C)(C)c1cc(CN2CCN(CCCCCC(c3ccc(F)cc3)c3ccc(F)cc3)CC2)cc(C(C)(C)C)c1,Bioorg Med Chem Lett,CHEMBL2031969,0.1,Yes,7
CHEMBL2033832,Inhibition of human Erg expressed in HEK293 cells by whole cell patch clamp analysis,COc1c(C(C)(C)C)cc(C(=O)N2CCN(C(=O)CCCCC(c3ccc(F)cc3)c3ccc(F)cc3)[C@@H](C)C2)cc1C(C)(C)C,Bioorg Med Chem Lett,CHEMBL2031973,0.9,Yes,6.045757491
CHEMBL2033832,Inhibition of human Erg expressed in HEK293 cells by whole cell patch clamp analysis,CC(C)(C)c1ccc(C(=O)NCC2CCN(C(=O)CCCCC(c3ccc(F)cc3)c3ccc(F)cc3)C2)cc1,Bioorg Med Chem Lett,CHEMBL2031975,0.82,Yes,6.086186148
CHEMBL2033832,Inhibition of human Erg expressed in HEK293 cells by whole cell patch clamp analysis,O=C(NCC1CCN(C(=O)CCCCC(c2ccc(F)cc2)c2ccc(F)cc2)C1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1,Bioorg Med Chem Lett,CHEMBL2031978,0.7,Yes,6.15490196
CHEMBL2033832,Inhibition of human Erg expressed in HEK293 cells by whole cell patch clamp analysis,COc1c(C(C)(C)C)cc(C(=O)NCC2CCN(CCCCCC(c3ccc(F)cc3)c3ccc(F)cc3)C2)cc1C(C)(C)C,Bioorg Med Chem Lett,CHEMBL2031980,0.1,Yes,7
CHEMBL2033832,Inhibition of human Erg expressed in HEK293 cells by whole cell patch clamp analysis,COc1cc(C(=O)NCC2CCN(CCCCCC(c3ccc(F)cc3)c3ccc(F)cc3)C2)cc(OC)c1OC,Bioorg Med Chem Lett,CHEMBL2031981,0.1,Yes,7
CHEMBL2033832,Inhibition of human Erg expressed in HEK293 cells by whole cell patch clamp analysis,O=C(NCC1CCN(CCCCCC(c2ccc(F)cc2)c2ccc(F)cc2)C1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1,Bioorg Med Chem Lett,CHEMBL2031982,0.1,Yes,7
CHEMBL2033832,Inhibition of human Erg expressed in HEK293 cells by whole cell patch clamp analysis,COc1cc(CNCC2CCN(CCCCCC(c3ccc(F)cc3)c3ccc(F)cc3)C2)cc(OC)c1OC,Bioorg Med Chem Lett,CHEMBL2031983,0.04,Yes,7.397940009
CHEMBL2033832,Inhibition of human Erg expressed in HEK293 cells by whole cell patch clamp analysis,CC(C)(C)c1cc(CNCC2CCN(CCCCCC(c3ccc(F)cc3)c3ccc(F)cc3)C2)cc(C(C)(C)C)c1O,Bioorg Med Chem Lett,CHEMBL2031984,0.87,Yes,6.060480747
CHEMBL2033832,Inhibition of human Erg expressed in HEK293 cells by whole cell patch clamp analysis,CC(C)(C)c1cc(CNCC2CCN(CCCCCC(c3ccc(F)cc3)c3ccc(F)cc3)C2)cc(C(C)(C)C)c1,Bioorg Med Chem Lett,CHEMBL2031985,0.46,Yes,6.337242168
CHEMBL2033832,Inhibition of human Erg expressed in HEK293 cells by whole cell patch clamp analysis,O=C(NC[C@H]1CCN(C(=O)CCCCC(c2ccc(F)cc2)c2ccc(F)cc2)C1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1,Bioorg Med Chem Lett,CHEMBL2031990,0.75,Yes,6.124938737
CHEMBL2033832,Inhibition of human Erg expressed in HEK293 cells by whole cell patch clamp analysis,O=C(NC[C@@H]1CCN(C(=O)CCCCC(c2ccc(F)cc2)c2ccc(F)cc2)C1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1,Bioorg Med Chem Lett,CHEMBL2031991,0.8,Yes,6.096910013
CHEMBL2033832,Inhibition of human Erg expressed in HEK293 cells by whole cell patch clamp analysis,COc1cc(C(=O)N2CCC(CNC(=O)CCCCC(c3ccc(F)cc3)c3ccc(F)cc3)C2)cc(OC)c1OC,Bioorg Med Chem Lett,CHEMBL2031996,0.75,Yes,6.124938737
CHEMBL2033832,Inhibition of human Erg expressed in HEK293 cells by whole cell patch clamp analysis,COc1c(C(C)(C)C)cc(C(=O)N2CCC(CNC(=O)CCCCC(c3ccc(F)cc3)c3ccc(F)cc3)C2)cc1C(C)(C)C,Bioorg Med Chem Lett,CHEMBL2031997,0.65,Yes,6.187086643
CHEMBL2033832,Inhibition of human Erg expressed in HEK293 cells by whole cell patch clamp analysis,COc1cc(CN2CCC(CNCCCCCC(c3ccc(F)cc3)c3ccc(F)cc3)C2)cc(OC)c1OC,Bioorg Med Chem Lett,CHEMBL2031998,0.1,Yes,7
CHEMBL2033832,Inhibition of human Erg expressed in HEK293 cells by whole cell patch clamp analysis,CC(C)(C)c1cc(CN2CCC(CNCCCCCC(c3ccc(F)cc3)c3ccc(F)cc3)C2)cc(C(C)(C)C)c1O,Bioorg Med Chem Lett,CHEMBL2031999,0.01,Yes,8
CHEMBL2033832,Inhibition of human Erg expressed in HEK293 cells by whole cell patch clamp analysis,COc1c(C(C)(C)C)cc(CN2CCC(CNCCCCCC(c3ccc(F)cc3)c3ccc(F)cc3)C2)cc1C(C)(C)C,Bioorg Med Chem Lett,CHEMBL2032000,0.11,Yes,6.958607315
CHEMBL2038474,Inhibition of human ERG,O=C(Nc1ccc(C(F)(F)F)c(Cl)c1)N1CCN(C[C@@H]2CCCN(C3CC3)C2)CC1,Bioorg Med Chem Lett,CHEMBL2036760,0.89,Yes,6.050609993
CHEMBL2038474,Inhibition of human ERG,O=C(Nc1ccc(Cl)c(Cl)c1)N1CCN(C[C@@H]2CCCN(CCCc3ccccc3)C2)CC1,Bioorg Med Chem Lett,CHEMBL2036756,0.4,Yes,6.397940009
CHEMBL2038474,Inhibition of human ERG,O=C(Nc1ccc(Cl)c(Cl)c1)N1CCN(C[C@@H]2CCCN(CC3CC3)C2)CC1,Bioorg Med Chem Lett,CHEMBL2036754,0.93,Yes,6.031517051
CHEMBL2038474,Inhibition of human ERG,O=C(Nc1ccc(Cl)c(Cl)c1)N1CCN(C[C@@H]2CCCN(Cc3ccccc3)C2)CC1,Bioorg Med Chem Lett,CHEMBL2036753,0.56,Yes,6.251811973
CHEMBL2039631,Inhibition of human ERG by electrophysiology assay,CC(C)N1CCN[C@@H](C(=O)N2CCN(C(=O)Nc3ccc(Cl)c(Cl)c3)CC2)C1,Bioorg Med Chem Lett,CHEMBL2036782,60,No,4.22184875
CHEMBL2037696,Displacement of [3H]astemizole from human Erg expressed in HEK293 cells after 75 mins,CN[C@H]1CC[C@@H](c2c[nH]c3ccc(NC(=N)c4cccs4)cc32)CC1.Cl,J Med Chem,CHEMBL2036268,39,No,4.408935393
CHEMBL2037696,Displacement of [3H]astemizole from human Erg expressed in HEK293 cells after 75 mins,CNC1CCCC(c2c[nH]c3ccc(NC(=N)c4cccs4)cc23)C1.Cl,J Med Chem,CHEMBL2036273,33,No,4.48148606
CHEMBL2044730,Inhibition of human ERG,O=C(O)c1cc(CN2CCN(c3ccc(C(F)(F)F)cc3)CC2)c2ccccn2c1=O,ACS Med Chem Lett,CHEMBL2042692,0.1,Yes,7
CHEMBL2045992,Binding affinity to human Erg,Cc1cccnc1CN1CCC2(CC1)C(=O)N(c1ccc(-c3ccccc3)cc1)C(=O)N2c1cc(O)ncn1,J Med Chem,CHEMBL2043004,0.22,Yes,6.657577319
CHEMBL2045992,Binding affinity to human Erg,COc1cc(N2C(=O)N(c3ccc(-c4ccc(C(=O)O)cc4F)cc3)C(=O)C23CCN(Cc2ncccc2C)CC3)ncn1,J Med Chem,CHEMBL2043324,54,No,4.26760624
CHEMBL2045992,Binding affinity to human Erg,Cc1nc(C)c(-c2ccc(N3C(=O)N(c4cc(O)ncn4)C4(CCN(Cc5ncccc5C)CC4)C3=O)cc2)s1,J Med Chem,CHEMBL2040897,0.95,Yes,6.022276395
CHEMBL2045992,Binding affinity to human Erg,COc1cc(N2C(=O)N(c3ccc(-c4ccc5cn[nH]c5c4)cc3)C(=O)C23CCN(Cc2ncccc2C)CC3)ncn1,J Med Chem,CHEMBL2041172,0.72,Yes,6.142667504
CHEMBL2045992,Binding affinity to human Erg,COc1cc(N2C(=O)N(c3ccc(-c4ccc(C#N)cc4)cc3)C(=O)C23CCN(Cc2ncccc2C)CC3)ncn1,J Med Chem,CHEMBL2041176,0.37,Yes,6.431798276
CHEMBL2045992,Binding affinity to human Erg,COc1cc(N2C(=O)N(c3ccc(-c4ccc(C(N)=O)cc4)cc3)C(=O)C23CCN(Cc2ncccc2C)CC3)ncn1,J Med Chem,CHEMBL2041177,0.65,Yes,6.187086643
CHEMBL2045992,Binding affinity to human Erg,COc1cc(N2C(=O)N(c3ccc(-c4ccc(C(=O)O)cc4)nc3)C(=O)C23CCN(Cc2ncccc2C)CC3)ncn1,J Med Chem,CHEMBL2041180,46,No,4.337242168
CHEMBL2045992,Binding affinity to human Erg,Cc1cc(N2C(=O)N(c3ccc(-c4ccc(C(=O)O)cc4C)cc3)C(=O)C23CCN(Cc2ncccc2C)CC3)ncn1,J Med Chem,CHEMBL2041182,38,No,4.420216403
CHEMBL2045992,Binding affinity to human Erg,Cc1cccnc1CN1CCC2(CC1)C(=O)N(c1ccc(-c3ccc(C(=O)O)cc3)cc1)C(=O)N2c1ccncn1,J Med Chem,CHEMBL2041192,31,No,4.508638306
CHEMBL2051179,Inhibition of human ERG expressed in HEK cells by patch clamp assay,c1ccc(CCCNCCC(c2ccccc2)c2ccccc2)cc1,J Med Chem,CHEMBL2046889,0.017,Yes,7.769551079
CHEMBL2051179,Inhibition of human ERG expressed in HEK cells by patch clamp assay,c1ccc(CCNCCN(c2ccccc2)c2ccccc2)cc1,J Med Chem,CHEMBL2046890,0.062,Yes,7.207608311
CHEMBL2051179,Inhibition of human ERG expressed in HEK cells by patch clamp assay,c1ccc(CCCNCCN(c2ccccc2)c2ccccc2)cc1,J Med Chem,CHEMBL2046891,0.58,Yes,6.236572006
CHEMBL2051179,Inhibition of human ERG expressed in HEK cells by patch clamp assay,Fc1ccc(N(CCNCCc2ccccc2)c2ccc(F)cc2)cc1,J Med Chem,CHEMBL2046892,0.044,Yes,7.356547324
CHEMBL2051179,Inhibition of human ERG expressed in HEK cells by patch clamp assay,Fc1ccc(N(CCNCCCc2ccccc2)c2ccc(F)cc2)cc1,J Med Chem,CHEMBL2046893,0.0024,Yes,8.619788758
CHEMBL2051179,Inhibition of human ERG expressed in HEK cells by patch clamp assay,O=C(CCc1ccccc1)NCCN(c1ccc(F)cc1)c1ccc(F)cc1,J Med Chem,CHEMBL2046895,0.192,Yes,6.716698771
CHEMBL2051179,Inhibition of human ERG expressed in HEK cells by patch clamp assay,c1ccc(CCCNCCC(c2ccccc2)c2ccccc2)cc1,J Med Chem,CHEMBL2046889,0.01585,Yes,7.799970733
CHEMBL2051179,Inhibition of human ERG expressed in HEK cells by patch clamp assay,c1ccc(CCNCCN(c2ccccc2)c2ccccc2)cc1,J Med Chem,CHEMBL2046890,0.0631,Yes,7.199970641
CHEMBL2051179,Inhibition of human ERG expressed in HEK cells by patch clamp assay,c1ccc(CCCNCCN(c2ccccc2)c2ccccc2)cc1,J Med Chem,CHEMBL2046891,0.63096,Yes,6.199998172
CHEMBL2051179,Inhibition of human ERG expressed in HEK cells by patch clamp assay,Fc1ccc(N(CCNCCc2ccccc2)c2ccc(F)cc2)cc1,J Med Chem,CHEMBL2046892,0.03981,Yes,7.400007822
CHEMBL2051179,Inhibition of human ERG expressed in HEK cells by patch clamp assay,Fc1ccc(N(CCNCCCc2ccccc2)c2ccc(F)cc2)cc1,J Med Chem,CHEMBL2046893,0.002512,Yes,8.599980365
CHEMBL2051179,Inhibition of human ERG expressed in HEK cells by patch clamp assay,O=C(CCc1ccccc1)NCCN(c1ccc(F)cc1)c1ccc(F)cc1,J Med Chem,CHEMBL2046895,0.19953,Yes,6.699991797
CHEMBL2060137,Inhibition of human ERG expressed in CHO cells after 30 mins by Rb+ flux assay,O=C1COc2ccccc2N1CCCN1CCC(n2c(=O)[nH]c3cnccc32)CC1,Bioorg Med Chem Lett,CHEMBL2059315,46,No,4.337242168
CHEMBL2066265,Inhibition of human ERG expressed in HEK293 cells coexpressing Kir2.3 after 30 mins by FluxOR based FLIPR assay,COc1ccc(CCN2CCC(Nc3nc4ccccc4n3Cc3ccc(F)cc3)CC2)cc1,J Nat Prod,CHEMBL296419,0.008,Yes,8.096910013
CHEMBL2066265,Inhibition of human ERG expressed in HEK293 cells coexpressing Kir2.3 after 30 mins by FluxOR based FLIPR assay,O=C(CCCN1CCC(O)(c2ccc(Cl)cc2)CC1)c1ccc(F)cc1,J Nat Prod,CHEMBL54,0.23,Yes,6.638272164
CHEMBL2072491,Displacement of [35S]MK499 from human Erg expressed in HEK293 cells after 60 mins by scintillation counting,CCCCC1(CCCC)N[C@@H](c2nc(-c3ccccc3)c[nH]2)Cc2c1[nH]c1ccccc21,ACS Med Chem Lett,CHEMBL2069499,0.15,Yes,6.823908741
CHEMBL2072491,Displacement of [35S]MK499 from human Erg expressed in HEK293 cells after 60 mins by scintillation counting,c1ccc(-c2c[nH]c([C@H]3Cc4c([nH]c5ccccc45)C(C4CCCCC4)N3)n2)cc1,ACS Med Chem Lett,CHEMBL2069500,0.077,Yes,7.113509275
CHEMBL2072491,Displacement of [35S]MK499 from human Erg expressed in HEK293 cells after 60 mins by scintillation counting,CCOCC1(COCC)N[C@@H](c2nc(-c3ccccc3)c[nH]2)Cc2c1[nH]c1ccccc21,ACS Med Chem Lett,CHEMBL2069501,0.176,Yes,6.754487332
CHEMBL2072491,Displacement of [35S]MK499 from human Erg expressed in HEK293 cells after 60 mins by scintillation counting,c1ccc(-c2c[nH]c([C@H]3Cc4c([nH]c5ccccc45)[C@@H](C4CCOCC4)N3)n2)cc1,ACS Med Chem Lett,CHEMBL2069502,0.38,Yes,6.420216403
CHEMBL2072491,Displacement of [35S]MK499 from human Erg expressed in HEK293 cells after 60 mins by scintillation counting,c1ccc(-c2c[nH]c([C@H]3Cc4c([nH]c5ccccc45)[C@H](C4CCOCC4)N3)n2)cc1,ACS Med Chem Lett,CHEMBL2069503,0.73,Yes,6.13667714
CHEMBL2072491,Displacement of [35S]MK499 from human Erg expressed in HEK293 cells after 60 mins by scintillation counting,c1ccc(-c2c[nH]c([C@H]3Cc4c([nH]c5ccccc45)C(C4CCOC4)N3)n2)cc1,ACS Med Chem Lett,CHEMBL2069504,0.064,Yes,7.193820026
CHEMBL2072491,Displacement of [35S]MK499 from human Erg expressed in HEK293 cells after 60 mins by scintillation counting,c1ccc(-c2c[nH]c([C@H]3Cc4c([nH]c5ccccc45)C(C4CCOC4)N3)n2)cc1,ACS Med Chem Lett,CHEMBL2069504,0.025,Yes,7.602059991
CHEMBL2072491,Displacement of [35S]MK499 from human Erg expressed in HEK293 cells after 60 mins by scintillation counting,c1ccc(-c2c[nH]c([C@H]3Cc4c([nH]c5ccccc45)C(C4CCSCC4)N3)n2)cc1,ACS Med Chem Lett,CHEMBL2069505,0.12,Yes,6.920818754
CHEMBL2072491,Displacement of [35S]MK499 from human Erg expressed in HEK293 cells after 60 mins by scintillation counting,[O-][S+]1CCC(C2N[C@@H](c3nc(-c4ccccc4)c[nH]3)Cc3c2[nH]c2ccccc32)CC1,ACS Med Chem Lett,CHEMBL2069506,0.1,Yes,7
CHEMBL2072491,Displacement of [35S]MK499 from human Erg expressed in HEK293 cells after 60 mins by scintillation counting,O=S1(=O)CCC(C2N[C@@H](c3nc(-c4ccccc4)c[nH]3)Cc3c2[nH]c2ccccc32)CC1,ACS Med Chem Lett,CHEMBL2069507,0.1,Yes,7
CHEMBL2072491,Displacement of [35S]MK499 from human Erg expressed in HEK293 cells after 60 mins by scintillation counting,COC(=O)N1CCC(C2N[C@@H](c3nc(-c4ccccc4)c[nH]3)Cc3c2[nH]c2ccccc32)CC1,ACS Med Chem Lett,CHEMBL2069512,0.7,Yes,6.15490196
CHEMBL2072491,Displacement of [35S]MK499 from human Erg expressed in HEK293 cells after 60 mins by scintillation counting,CNC(=O)N1CCC(C2N[C@@H](c3nc(-c4ccccc4)c[nH]3)Cc3c2[nH]c2ccccc32)CC1,ACS Med Chem Lett,CHEMBL2069513,0.24,Yes,6.619788758
CHEMBL2072927,Inhibition of human ERG channel expressed in CHO cells by patch clamp assay,CCOC(=O)N1CCN(Cc2noc(-c3cc(Cl)ccc3F)n2)CC1,J Med Chem,CHEMBL2069930,31,No,4.508638306
CHEMBL2073369,Inhibition of human ERG,N#CC1(NC(=O)[C@@H]2CCCC[C@H]2C(=O)N2CCN(c3ccc(F)cc3)CC2)CC1,Bioorg Med Chem Lett,CHEMBL2070936,31.62278,No,4.499999953
CHEMBL2149353,Inhibition of human ERG,CN1CCC(CNc2ccc3ncc(-c4cccc(OC(F)(F)F)c4)n3n2)CC1,J Med Chem,CHEMBL1952329,0.98,Yes,6.008773924
CHEMBL2150564,Displacement of [3H]dofetilide from human ERG,CCCCN1CCC[C@@H]1Cn1nc(Cc2ccc(Cl)cc2)c2cnccc2c1=O,Bioorg Med Chem,CHEMBL2146806,0.05012,Yes,7.299988938
CHEMBL2150564,Displacement of [3H]dofetilide from human ERG,CCCCN1CCC[C@@H]1Cn1nc(Cc2ccc(Cl)cc2)c2cccnc2c1=O,Bioorg Med Chem,CHEMBL2146807,0.07943,Yes,7.100015437
CHEMBL2150564,Displacement of [3H]dofetilide from human ERG,CN1CCC[C@@H]1Cn1nc(Cc2ccc(Cl)cc2)c2ncccc2c1=O,Bioorg Med Chem,CHEMBL2146809,0.15849,Yes,6.799998135
CHEMBL2150564,Displacement of [3H]dofetilide from human ERG,CCCCN1CCC[C@@H]1Cn1nc(Cc2ccc(Cl)cc2)c2ncccc2c1=O,Bioorg Med Chem,CHEMBL2146810,0.003981,Yes,8.400007822
CHEMBL2150564,Displacement of [3H]dofetilide from human ERG,COCCN1CCC[C@@H]1Cn1nc(Cc2ccc(Cl)cc2)c2ncccc2c1=O,Bioorg Med Chem,CHEMBL2146811,0.0631,Yes,7.199970641
CHEMBL2150564,Displacement of [3H]dofetilide from human ERG,O=c1c2ccncc2c(Cc2ccc(Cl)cc2)nn1C[C@H]1CCCN1CCCCc1ccc(OCCCN2CCCCCC2)cc1,Bioorg Med Chem,CHEMBL2146813,0.15849,Yes,6.799998135
CHEMBL2150564,Displacement of [3H]dofetilide from human ERG,O=c1c2ccccc2c(Cc2ccc(Cl)cc2)nn1C[C@H]1CCCN1CCCCc1ccc(OCCCN2CCCCCC2)cc1,Bioorg Med Chem,CHEMBL1767164,0.05012,Yes,7.299988938
CHEMBL2150564,Displacement of [3H]dofetilide from human ERG,CN1CCCC(n2nc(Cc3ccc(Cl)cc3)c3ccccc3c2=O)CC1,Bioorg Med Chem,CHEMBL639,0.1,Yes,7
CHEMBL2150564,Displacement of [3H]dofetilide from human ERG,CN1CCC[C@@H]1Cn1nc(Cc2ccc(Cl)cc2)c2ccccc2c1=O,Bioorg Med Chem,CHEMBL1767136,0.19953,Yes,6.699991797
CHEMBL2150564,Displacement of [3H]dofetilide from human ERG,CCCCN1CCC[C@@H]1Cn1nc(Cc2ccc(Cl)cc2)c2ccccc2c1=O,Bioorg Med Chem,CHEMBL2146802,0.01585,Yes,7.799970733
CHEMBL2150564,Displacement of [3H]dofetilide from human ERG,COCCN1CCC[C@@H]1Cn1nc(Cc2ccc(Cl)cc2)c2ccccc2c1=O,Bioorg Med Chem,CHEMBL2146803,0.25119,Yes,6.599997654
CHEMBL2149604,Binding affinity to human ERG,O=c1[nH]c2ccccc2n1C1CCN(CCCOc2ccc(F)cc2)CC1,ACS Med Chem Lett,CHEMBL1802360,0.07943,Yes,7.100015437
CHEMBL2148626,Displacement of [35S]MK499 from human ERG,O=[N+]([O-])c1ccc(CCN2CCNCC2)cc1,ACS Med Chem Lett,CHEMBL2146754,0.19,Yes,6.721246399
CHEMBL2148626,Displacement of [35S]MK499 from human ERG,O=[N+]([O-])c1ccc(CCN2CCN(CCc3ccc([N+](=O)[O-])cc3)CC2)cc1,ACS Med Chem Lett,CHEMBL2146755,0.005,Yes,8.301029996
CHEMBL2148626,Displacement of [35S]MK499 from human ERG,N#Cc1ccc(CCN2CCN(CCc3ccc([N+](=O)[O-])cc3)CC2)cc1,ACS Med Chem Lett,CHEMBL2146757,0.009,Yes,8.045757491
CHEMBL2148626,Displacement of [35S]MK499 from human ERG,N#Cc1cccc(CCN2CCN(CCc3ccc([N+](=O)[O-])cc3)CC2)c1,ACS Med Chem Lett,CHEMBL2146852,0.022,Yes,7.657577319
CHEMBL2148626,Displacement of [35S]MK499 from human ERG,O=[N+]([O-])c1ccc(CCN2CCN(CCc3ccc4nonc4c3)CC2)cc1,ACS Med Chem Lett,CHEMBL2146853,0.025,Yes,7.602059991
CHEMBL2148626,Displacement of [35S]MK499 from human ERG,O=[N+]([O-])c1ccc(CCN2CCN(CCc3ccc(-c4ncco4)cc3)CC2)cc1,ACS Med Chem Lett,CHEMBL2146854,0.047,Yes,7.327902142
CHEMBL2148626,Displacement of [35S]MK499 from human ERG,O=C1OCc2c1cccc2-c1ccc(CCN2CCN(CCc3ccc([N+](=O)[O-])cc3)CC2)cc1,ACS Med Chem Lett,CHEMBL2146856,0.15,Yes,6.823908741
CHEMBL2148626,Displacement of [35S]MK499 from human ERG,CCOC(=O)c1ccc(CCN2CCN(CCc3ccc([N+](=O)[O-])cc3)CC2)cc1,ACS Med Chem Lett,CHEMBL2146857,0.019,Yes,7.721246399
CHEMBL2148626,Displacement of [35S]MK499 from human ERG,O=[N+]([O-])c1ccc(CCN2CCN(CCc3ccc(F)cc3)CC2)cc1,ACS Med Chem Lett,CHEMBL2146858,0.023,Yes,7.638272164
CHEMBL2148626,Displacement of [35S]MK499 from human ERG,COc1ccc(CCN2CCN(CCc3ccc([N+](=O)[O-])cc3)CC2)cc1,ACS Med Chem Lett,CHEMBL2146861,0.007,Yes,8.15490196
CHEMBL2148626,Displacement of [35S]MK499 from human ERG,CS(=O)(=O)c1ccc(CCN2CCN(CCc3ccc([N+](=O)[O-])cc3)CC2)cc1,ACS Med Chem Lett,CHEMBL2146862,0.15,Yes,6.823908741
CHEMBL2148626,Displacement of [35S]MK499 from human ERG,CC(CN1CCN(CCc2ccc([N+](=O)[O-])cc2)CC1)c1ccc([N+](=O)[O-])cc1,ACS Med Chem Lett,CHEMBL2146865,0.0031,Yes,8.508638306
CHEMBL2148626,Displacement of [35S]MK499 from human ERG,CC(Cc1ccc([N+](=O)[O-])cc1)N1CCN(CCc2ccc([N+](=O)[O-])cc2)CC1,ACS Med Chem Lett,CHEMBL2146866,0.0039,Yes,8.408935393
CHEMBL2148626,Displacement of [35S]MK499 from human ERG,CC1CN(CCc2ccc([N+](=O)[O-])cc2)CCN1CCc1ccc([N+](=O)[O-])cc1,ACS Med Chem Lett,CHEMBL2146867,0.00076,Yes,9.119186408
CHEMBL2148626,Displacement of [35S]MK499 from human ERG,N#Cc1ccc(CCN2CCN(CCc3ccc(C#N)cc3)CC2)cc1,ACS Med Chem Lett,CHEMBL2146868,0.012,Yes,7.920818754
CHEMBL2148626,Displacement of [35S]MK499 from human ERG,c1cc2nonc2cc1CCN1CCN(CCc2ccc3nonc3c2)CC1,ACS Med Chem Lett,CHEMBL2146869,0.067,Yes,7.173925197
CHEMBL2148626,Displacement of [35S]MK499 from human ERG,N#Cc1ccc(CCN2CCN(CCc3ccc4c(c3)COC4=O)CC2)cc1,ACS Med Chem Lett,CHEMBL2146871,0.43,Yes,6.366531544
CHEMBL2148626,Displacement of [35S]MK499 from human ERG,O=C1OCc2cc(CCN3CCN(CCc4ccc5nonc5c4)CC3)ccc21,ACS Med Chem Lett,CHEMBL2146872,0.28,Yes,6.552841969
CHEMBL2148626,Displacement of [35S]MK499 from human ERG,N#Cc1ccc(CCN2CCN(CCc3ccc4nonc4c3)CC2)cc1,ACS Med Chem Lett,CHEMBL2146851,0.042,Yes,7.37675071
CHEMBL2148626,Displacement of [35S]MK499 from human ERG,N#Cc1ccc(CCN2CCN(CCc3ccc4c(c3)COC4=O)CC2)cc1F,ACS Med Chem Lett,CHEMBL2146873,0.17,Yes,6.769551079
CHEMBL2148626,Displacement of [35S]MK499 from human ERG,N#Cc1ccc(CCN2CCN(CCc3ccc4c(c3)COC4=O)CC2)cc1Cl,ACS Med Chem Lett,CHEMBL2146874,0.12,Yes,6.920818754
CHEMBL2148626,Displacement of [35S]MK499 from human ERG,N#Cc1ccc(CCN2CCN(CCc3ccc4c(c3)COC4=O)CC2)cc1Br,ACS Med Chem Lett,CHEMBL2146875,0.56,Yes,6.251811973
CHEMBL2148626,Displacement of [35S]MK499 from human ERG,CCOc1cc(CCN2CCN(CCc3ccc4c(c3)COC4=O)CC2)ccc1C#N,ACS Med Chem Lett,CHEMBL2146877,0.67,Yes,6.173925197
CHEMBL2148626,Displacement of [35S]MK499 from human ERG,N#Cc1ccc(CCN2CCN(CCc3ccc4c(c3)COC4=O)CC2)cc1OC(F)(F)F,ACS Med Chem Lett,CHEMBL2146878,0.11,Yes,6.958607315
CHEMBL2148626,Displacement of [35S]MK499 from human ERG,N#Cc1ccc(CCN2CCN(CCc3ccc4c(c3)COC4=O)CC2)cc1OC1CC1,ACS Med Chem Lett,CHEMBL2146879,0.47,Yes,6.327902142
CHEMBL2148626,Displacement of [35S]MK499 from human ERG,CSc1cc(CCN2CCN(CCc3ccc4c(c3)COC4=O)CC2)ccc1C#N,ACS Med Chem Lett,CHEMBL2146880,0.46,Yes,6.337242168
CHEMBL2148626,Displacement of [35S]MK499 from human ERG,CNc1cc(CCN2CCN(CCc3ccc4c(c3)COC4=O)CC2)ccc1C#N,ACS Med Chem Lett,CHEMBL2146881,0.67,Yes,6.173925197
CHEMBL2149459,Inhibition of human ERG channel by whole cell voltage-clamp electrophysiology assay,Cc1ncc(-c2ccccc2CCNC(=O)c2ccc(OCCOCC(F)(F)F)nc2)cn1,Bioorg Med Chem Lett,CHEMBL2147217,31.62278,No,4.499999953
CHEMBL2154697,Inhibition of human ERG,CC(C)Oc1cc(-n2cnc3ccc(N[C@@H](CO)c4ccc(F)cn4)nc32)n[nH]1,ACS Med Chem Lett,CHEMBL2151322,52,No,4.283996656
CHEMBL2154697,Inhibition of human ERG,CCOc1cc(Nc2nc3c(cc2F)ncn3[C@@H](CO)c2ccc(F)cn2)n[nH]1,ACS Med Chem Lett,CHEMBL2151325,32,No,4.494850022
CHEMBL2153967,Inhibition of human ERG expressed in CHOK1 cells,c1ccc([C@@H]([C@H](c2ccccc2)N2CCCCC2)N2CCCCC2)cc1,ACS Med Chem Lett,CHEMBL2152522,31.62278,No,4.499999953
CHEMBL2153967,Inhibition of human ERG expressed in CHOK1 cells,c1ccc([C@@H]([C@H](c2ccccc2)N2CCCC2)N2CCCC2)cc1,ACS Med Chem Lett,CHEMBL2152524,31.62278,No,4.499999953
CHEMBL2153967,Inhibition of human ERG expressed in CHOK1 cells,c1ccc([C@H]([C@@H](c2ccccc2)N2CCCC2)N2CCCC2)cc1,ACS Med Chem Lett,CHEMBL2152525,31.62278,No,4.499999953
CHEMBL2161976,Inhibition of human ERG,COc1ccc2ncc(F)c([C@@H](O)CC[C@@H]3CCN(CCSc4cccs4)C[C@@H]3C(=O)O)c2c1,J Med Chem,CHEMBL2158050,124,No,3.906578315
CHEMBL2160723,"Displacement of 3,7-Bis[2-(4-nitro[3,5-3H]phenyl)ethyl]-3,7-diazabicyclo[3.3.1]nonane from human ERG expressed in HEK cells after 3 hrs by TopCount analysis",Cc1cc(Cl)ccc1OC1CCN(CC2CCN([C@@](C)(Cc3ccc(F)cc3)C(=O)O)CC2)CC1,Bioorg Med Chem Lett,CHEMBL2158791,31.62278,No,4.499999953
CHEMBL2160723,"Displacement of 3,7-Bis[2-(4-nitro[3,5-3H]phenyl)ethyl]-3,7-diazabicyclo[3.3.1]nonane from human ERG expressed in HEK cells after 3 hrs by TopCount analysis",O=C(O)c1cccnc1N1CCC(CN2CCC(Oc3ccc(Cl)c(Cl)c3)CC2)CC1,Bioorg Med Chem Lett,CHEMBL2158834,31.62278,No,4.499999953
CHEMBL2160723,"Displacement of 3,7-Bis[2-(4-nitro[3,5-3H]phenyl)ethyl]-3,7-diazabicyclo[3.3.1]nonane from human ERG expressed in HEK cells after 3 hrs by TopCount analysis",O=C(O)c1ccc(CN2CCC(CN3CCC(Oc4ccc(Cl)c(Cl)c4)CC3)CC2)cc1,Bioorg Med Chem Lett,CHEMBL2158833,31.62278,No,4.499999953
CHEMBL2160723,"Displacement of 3,7-Bis[2-(4-nitro[3,5-3H]phenyl)ethyl]-3,7-diazabicyclo[3.3.1]nonane from human ERG expressed in HEK cells after 3 hrs by TopCount analysis",O=C(O)COc1ccccc1N1CCC(CN2CCC(Oc3ccc(Cl)c(Cl)c3)CC2)CC1,Bioorg Med Chem Lett,CHEMBL2158828,31.62278,No,4.499999953
CHEMBL2160723,"Displacement of 3,7-Bis[2-(4-nitro[3,5-3H]phenyl)ethyl]-3,7-diazabicyclo[3.3.1]nonane from human ERG expressed in HEK cells after 3 hrs by TopCount analysis",O=C(O)Cc1ccc(N2CCC(CN3CCC(Oc4ccc(Cl)c(Cl)c4)CC3)CC2)cc1,Bioorg Med Chem Lett,CHEMBL2158827,31.62278,No,4.499999953
CHEMBL2160723,"Displacement of 3,7-Bis[2-(4-nitro[3,5-3H]phenyl)ethyl]-3,7-diazabicyclo[3.3.1]nonane from human ERG expressed in HEK cells after 3 hrs by TopCount analysis",O=C(O)Cc1cccc(N2CCC(CN3CCC(Oc4ccc(Cl)c(Cl)c4)CC3)CC2)c1,Bioorg Med Chem Lett,CHEMBL2158826,31.62278,No,4.499999953
CHEMBL2160723,"Displacement of 3,7-Bis[2-(4-nitro[3,5-3H]phenyl)ethyl]-3,7-diazabicyclo[3.3.1]nonane from human ERG expressed in HEK cells after 3 hrs by TopCount analysis",O=C(O)c1ccc(N2CCC(CN3CCC(Oc4ccc(Cl)c(Cl)c4)CC3)CC2)cc1,Bioorg Med Chem Lett,CHEMBL2158824,31.62278,No,4.499999953
CHEMBL2160723,"Displacement of 3,7-Bis[2-(4-nitro[3,5-3H]phenyl)ethyl]-3,7-diazabicyclo[3.3.1]nonane from human ERG expressed in HEK cells after 3 hrs by TopCount analysis",O=C(O)c1cccc(N2CCC(CN3CCC(Oc4ccc(Cl)c(Cl)c4)CC3)CC2)c1,Bioorg Med Chem Lett,CHEMBL2158823,31.62278,No,4.499999953
CHEMBL2168489,Binding affinity to human ERG expressed in CHOK1 cells by IonWorks HT assay,CC(CC#N)N1C(=O)c2ccccc2C1C(=O)NCc1ccc(OC(F)(F)F)cc1,J Med Chem,CHEMBL2164380,31,No,4.508638306
CHEMBL2166760,Displacement of [3H]-astemizole from human ERG expressed in HEK293 cells after 60 mins by liquid scintillation counter,N#Cc1ccc2ccc(=O)n(CCN3CC[C@H](NCc4cc5c(cn4)OCCO5)[C@@H](F)C3)c2c1,J Med Chem,CHEMBL2165068,57,No,4.244125144
CHEMBL2166760,Displacement of [3H]-astemizole from human ERG expressed in HEK293 cells after 60 mins by liquid scintillation counter,N#Cc1ccc2ccc(=O)n(CCN3CCC(NCc4cc5c(cn4)OCCO5)CC3)c2c1,J Med Chem,CHEMBL2165062,39,No,4.408935393
CHEMBL2166761,Inhibition of human ERG by Ionworks assay,COc1ccc2ncc(=O)n(CCN3CC[C@H](NCc4cc5c(cn4)OCCO5)[C@@H](OC)C3)c2c1,J Med Chem,CHEMBL2165060,93,No,4.031517051
CHEMBL2166761,Inhibition of human ERG by Ionworks assay,CO[C@@H]1CN(CCn2c(=O)ccc3ccc(C#N)cc32)CC[C@H]1NCc1ccc2c(n1)NC(=O)CO2,J Med Chem,CHEMBL2165059,124,No,3.906578315
CHEMBL2166761,Inhibition of human ERG by Ionworks assay,CO[C@H]1CN(CCn2c(=O)ccc3ccc(C#N)cc32)CC[C@@H]1NCc1cc2c(cn1)OCCO2,J Med Chem,CHEMBL2165058,176,No,3.754487332
CHEMBL2166761,Inhibition of human ERG by Ionworks assay,COc1ccc2ncc(=O)n(CCN3CC[C@@H](NCc4ccc5c(n4)NC(=O)CO5)[C@@H](OC)C3)c2c1,J Med Chem,CHEMBL2165057,88,No,4.055517328
CHEMBL2166761,Inhibition of human ERG by Ionworks assay,COc1ccc2ncc(=O)n(CCN3CC[C@@H](NCc4cc5c(cn4)OCCO5)[C@@H](OC)C3)c2c1,J Med Chem,CHEMBL2165056,75,No,4.124938737
CHEMBL2166761,Inhibition of human ERG by Ionworks assay,CO[C@H]1CN(CCn2c(=O)ccc3ccc(C#N)cc32)CC[C@H]1NCc1ccc2c(n1)NC(=O)CO2,J Med Chem,CHEMBL2165055,189,No,3.723538196
CHEMBL2166761,Inhibition of human ERG by Ionworks assay,CO[C@H]1CN(CCn2c(=O)ccc3ccc(C#N)cc32)CC[C@H]1NCc1cc2c(cn1)OCCO2,J Med Chem,CHEMBL2165054,174,No,3.759450752
CHEMBL2166761,Inhibition of human ERG by Ionworks assay,COc1ccc2ncc(=O)n(CCN3CC[C@@H](NCc4ccc5c(n4)NC(=O)CO5)[C@@H](O)C3)c2c1,J Med Chem,CHEMBL2164747,152,No,3.818156412
CHEMBL2166761,Inhibition of human ERG by Ionworks assay,COc1ccc2ncc(=O)n(CCN3CC[C@H](NCc4ccc5c(n4)NC(=O)CO5)[C@H](O)C3)c2c1,J Med Chem,CHEMBL2164746,172,No,3.764471553
CHEMBL2166761,Inhibition of human ERG by Ionworks assay,N#Cc1ccc2ccc(=O)n(CCN3CC[C@H](NCc4ccc5c(n4)NC(=O)CO5)[C@H](O)C3)c2c1,J Med Chem,CHEMBL2164742,305,No,3.515700161
CHEMBL2166761,Inhibition of human ERG by Ionworks assay,N#Cc1ccc2ccc(=O)n(CCN3CC[C@@H](NCc4cc5c(cn4)OCCO5)[C@@H](O)C3)c2c1,J Med Chem,CHEMBL2164741,117,No,3.931814138
CHEMBL2166761,Inhibition of human ERG by Ionworks assay,N#Cc1ccc2ccc(=O)n(CCN3CC[C@H](NCc4cc5c(cn4)OCCO5)[C@H](O)C3)c2c1,J Med Chem,CHEMBL2164740,156,No,3.806875402
CHEMBL2166761,Inhibition of human ERG by Ionworks assay,COc1ccc2ncc(=O)n(CCN3CC[C@H](NCc4cc5c(cn4)OCCO5)[C@@H](F)C3)c2c1,J Med Chem,CHEMBL2165069,75,No,4.124938737
CHEMBL2166761,Inhibition of human ERG by Ionworks assay,N#Cc1ccc2ccc(=O)n(CCN3CC[C@H](NCc4cc5c(cn4)OCCO5)[C@@H](F)C3)c2c1,J Med Chem,CHEMBL2165068,122,No,3.913640169
CHEMBL2166761,Inhibition of human ERG by Ionworks assay,COc1ccc2ncc(=O)n(CCN3CC[C@@H](NCc4ccc5c(n4)NC(=O)CO5)[C@@H](F)C3)c2c1,J Med Chem,CHEMBL2165067,32,No,4.494850022
CHEMBL2166761,Inhibition of human ERG by Ionworks assay,N#Cc1ccc2ccc(=O)n(CCN3CC[C@@H](NCc4ccc5c(n4)NC(=O)CO5)[C@@H](F)C3)c2c1,J Med Chem,CHEMBL2165066,168,No,3.774690718
CHEMBL2166761,Inhibition of human ERG by Ionworks assay,N#Cc1ccc2ccc(=O)n(CCN3CC[C@@H](NCc4cc5c(cn4)OCCO5)[C@@H](F)C3)c2c1,J Med Chem,CHEMBL2165065,199,No,3.701146924
CHEMBL2166761,Inhibition of human ERG by Ionworks assay,N#Cc1ccc2ccc(=O)n(CCN3CC[C@H](NCc4cc5c(cn4)OCCO5)[C@H](F)C3)c2c1,J Med Chem,CHEMBL2165064,233,No,3.632644079
CHEMBL2166761,Inhibition of human ERG by Ionworks assay,COc1ccc2ncc(=O)n(CCN3CCC(NCc4ccc5c(n4)NC(=O)CO5)CC3)c2c1,J Med Chem,CHEMBL2165063,35,No,4.455931956
CHEMBL2166761,Inhibition of human ERG by Ionworks assay,N#Cc1ccc2ccc(=O)n(CCN3CCC(NCc4cc5c(cn4)OCCO5)CC3)c2c1,J Med Chem,CHEMBL2165062,44,No,4.356547324
CHEMBL2168044,Inhibition of human recombinant hERG expressed in CHO cells by automated patch clamp assay,CONC(=O)N(Cc1ccsc1)C1CCN([C@H](C)CCNC(=O)c2c(C)cc(C(=O)NC(C)C)nc2C)CC1,ACS Med Chem Lett,CHEMBL2164208,33,No,4.48148606
CHEMBL2168044,Inhibition of human recombinant hERG expressed in CHO cells by automated patch clamp assay,CONC(=O)N(Cc1ccsc1)C1CCN([C@H](C)CCNC(=O)c2c(C)cc(Cl)nc2Cl)CC1,ACS Med Chem Lett,CHEMBL2164207,0.3,Yes,6.522878745
CHEMBL2173968,Inhibition of human ERG expressed in CHO cells by IonworksHT assay,Cc1ccc(S(=O)(=O)N(C)C(=O)N2CCC(N3CCC(Oc4ccc(Cl)c(Cl)c4)CC3)CC2)cc1,Bioorg Med Chem Lett,CHEMBL2171013,0.31623,Yes,6.499996932
CHEMBL2176358,Inhibition of human ERG expressed in CHOK1 cells by patch clamp technique,Cl.Clc1ccc(OC(c2ccc3ccccc3c2)C2CNC2)cc1Cl,J Med Chem,CHEMBL2171418,0.18,Yes,6.744727495
CHEMBL2176358,Inhibition of human ERG expressed in CHOK1 cells by patch clamp technique,Cl.c1ccc(OC(c2ccc3ccccc3c2)C2CNC2)cc1,J Med Chem,CHEMBL2171417,0.83,Yes,6.080921908
CHEMBL2176358,Inhibition of human ERG expressed in CHOK1 cells by patch clamp technique,CCCOC(c1ccc2ccccc2c1)C1CNC1.Cl,J Med Chem,CHEMBL2171416,0.98,Yes,6.008773924
CHEMBL2176468,Inhibition of human recombinant ERG channel expressed in HEK297 cells after 3 to 8 mins by voltage clamp assay,CNc1nn2cc3c(nc2c1S(=O)(=O)c1ccccc1)CCN(C)C3,Bioorg Med Chem Lett,CHEMBL2172192,0.5,Yes,6.301029996
CHEMBL2176468,Inhibition of human recombinant ERG channel expressed in HEK297 cells after 3 to 8 mins by voltage clamp assay,CNc1nn2c3c(cnc2c1S(=O)(=O)c1ccccc1)CN(C)CC3,Bioorg Med Chem Lett,CHEMBL2172186,54.2,No,4.266000713
CHEMBL2184102,Displacement of dofetilide from human ERG,C=CC(=O)N1CCC[C@@H](n2nc(-c3cccc(C(=O)Nc4ccc(C(C)C)c(C)c4)c3)c3c(N)ncnc32)C1,J Med Chem,CHEMBL2179805,0.3,Yes,6.522878745
CHEMBL2186404,Inhibition of human ERG expressed in rat after 2 to 3 days by patch clamp assay,CCCN1CNc2cc(Nc3ccnc4cc(Cl)ccc34)ccc2C1,J Med Chem,CHEMBL2181207,0.022,Yes,7.657577319
CHEMBL2182706,Inhibition of human ERG expressed in CHO cells by IonWorks assay,COc1ccc(C2(c3cccc(-c4cncnc4)c3)N=C(N)c3c(F)cccc32)cc1,J Med Chem,CHEMBL2177916,0.5,Yes,6.301029996
CHEMBL2184863,Inhibition of human ERG,CC(=O)c1cccc(NC(=O)N[C@@H]2CCCC[C@H]2CN2CCC[C@@H](Cc3ccc(F)cc3)C2)c1,J Med Chem,CHEMBL250689,0.4,Yes,6.397940009
CHEMBL2184696,Inhibition of human ERG,C[C@H](c1nc2c(cnn2C2CCCC2)c(=O)[nH]1)N1CC(c2ncccn2)C1,J Med Chem,CHEMBL2180070,53.5,No,4.271646218
CHEMBL2182407,Inhibition of human ERG expressed in CHO cells by whole cell voltage clamp assay,O=C(N[C@@H]1C2CCN(CC2)[C@H]1Cc1cccnc1)c1cc2ccccc2o1,J Med Chem,CHEMBL1258006,54,No,4.26760624
CHEMBL2184356,Inhibition of human ERG,CC(=O)Nc1ccc(CCN2CCC(COc3nc4ccccc4c4cn(C)cc34)CC2)cc1,J Med Chem,CHEMBL2179670,0.02,Yes,7.698970004
CHEMBL2184356,Inhibition of human ERG,COCc1ccc(CCN2CCC(COc3nc4ccccc4c4cn(C)cc34)CC2)cc1,J Med Chem,CHEMBL2179671,0.02,Yes,7.698970004
CHEMBL2184356,Inhibition of human ERG,Cn1cc2c(OCC3CCN(CCc4ccc(CO)cc4)CC3)nc3ccccc3c2c1,J Med Chem,CHEMBL2179672,0.01,Yes,8
CHEMBL2184356,Inhibition of human ERG,Cl.Cn1cc2c(OCC3CCN(CCc4ccc(N)cc4)CC3)nc3ccccc3c2c1,J Med Chem,CHEMBL2179675,0.05,Yes,7.301029996
CHEMBL2184356,Inhibition of human ERG,CC(C)n1nc(C(=O)NCC2CCN(CCN3CCOCC3)CC2)c2ccccc21.Cl.Cl,J Med Chem,CHEMBL3215681,32.5,No,4.488116639
CHEMBL2208705,Inhibition of human ERG,CN(C)CCCCc1ccc(C2(C)COC2)cc1,J Med Chem,CHEMBL1084000,35,No,4.455931956
CHEMBL2215011,Displacement of [3H]astemizole from human recombinant ERG expressed in HEK293 cells,N=C(Nc1ccc2c(c1)CCN2C1CCNCC1)c1cccs1,Eur J Med Chem,CHEMBL2203713,160,No,3.795880017
CHEMBL2208784,Inhibition of human Erg expressed in human HEK293 cells,c1cc([C@H]2C[C@@H](CN3CCOCC3)C2)ccc1CN1CCCC1,J Med Chem,CHEMBL2206288,300,No,3.522878745
CHEMBL2216324,Displacement of [3H]-astemizole from human ERG expressed in HEK293 cells after 1 hr by scintillation counting analysis,O=C(CNC(=O)c1cccc(C(F)(F)F)c1)NC1CN([C@H]2CC[C@@](O)(c3nccs3)CC2)C1,ACS Med Chem Lett,CHEMBL2204259,32,No,4.494850022
CHEMBL2216324,Displacement of [3H]-astemizole from human ERG expressed in HEK293 cells after 1 hr by scintillation counting analysis,COc1ccc([C@]2(O)CC[C@H](N3CC(NC(=O)CNC(=O)c4cccc(C(F)(F)F)c4)C3)CC2)cn1,ACS Med Chem Lett,CHEMBL2204244,37,No,4.431798276
CHEMBL2216324,Displacement of [3H]-astemizole from human ERG expressed in HEK293 cells after 1 hr by scintillation counting analysis,Cc1ccc([C@]2(O)CC[C@H](N3CC(NC(=O)CNC(=O)c4cccc(C(F)(F)F)c4)C3)CC2)cn1,ACS Med Chem Lett,CHEMBL2204243,35,No,4.455931956
CHEMBL2216324,Displacement of [3H]-astemizole from human ERG expressed in HEK293 cells after 1 hr by scintillation counting analysis,O=C(CNC(=O)c1cccc(C(F)(F)F)c1)NC1CN([C@H]2CC[C@@](O)(c3cncnc3)CC2)C1,ACS Med Chem Lett,CHEMBL2204269,43.8,No,4.358525889
CHEMBL2211966,Binding affinity to human ERG,N#Cc1ccc(N2CCN(Cc3cc(C(=O)N[C@H]4CCCC[C@@H]4O)c(=O)n4ccccc34)CC2)cc1,ACS Med Chem Lett,CHEMBL2204275,0.39,Yes,6.408935393
CHEMBL2215146,"Displacement of 3,7-Bis[2-(4-nitro[3,5]-[3H]phenyl)ethyl]-3,7-diazabicyclo[3.3.1]nonane from human ERG expressed in HEK cells after 3hrs",O=C(NC[C@@H](O)CN1CCC(Oc2ccc(Cl)c(Cl)c2)CC1)c1c[nH]c(=O)c2cc(S(=O)(=O)NC3CC3)ccc12,Bioorg Med Chem Lett,CHEMBL2207285,0.79433,Yes,6.099999035
CHEMBL2215806,Inhibition of human ERG in HEK cells by ion flux electrophysiology assay,O=C(NC[C@@H](O)CN1CCC(Oc2ccc(Cl)c(Cl)c2)CC1)c1n[nH]c2ccccc12,Bioorg Med Chem Lett,CHEMBL2208429,0.25119,Yes,6.599997654
CHEMBL2215806,Inhibition of human ERG in HEK cells by ion flux electrophysiology assay,COc1cc(C(=O)NC[C@@H](O)CN2CCC(Oc3ccc(Cl)c(Cl)c3)CC2)ccc1N,Bioorg Med Chem Lett,CHEMBL2208427,0.25119,Yes,6.599997654
CHEMBL2215806,Inhibition of human ERG in HEK cells by ion flux electrophysiology assay,O=C(NC[C@@H](O)CN1CCC(Oc2ccc(Cl)c(Cl)c2)CC1)c1n[nH]c(=O)c2ccccc12,Bioorg Med Chem Lett,CHEMBL2208431,0.39811,Yes,6.399996913
CHEMBL2215806,Inhibition of human ERG in HEK cells by ion flux electrophysiology assay,O=C(NC[C@@H](O)CN1CCC(Oc2ccc(Cl)c(Cl)c2)CC1)n1c(=O)[nH]c2ccccc21,Bioorg Med Chem Lett,CHEMBL2208432,0.50119,Yes,6.299997603
CHEMBL2320519,Inhibition of human ERG assessed as [3H]astemizole binding activity,O=C(CNc1nccc2ccc(C(F)(F)F)cc12)NC1CN([C@H]2CC[C@@](O)(c3cncs3)CC2)C1,Bioorg Med Chem Lett,CHEMBL2316209,32.9,No,4.482804102
CHEMBL2320519,Inhibition of human ERG assessed as [3H]astemizole binding activity,N#Cc1cc(NCC(=O)NC2CN([C@H]3CC[C@@](O)(c4cncs4)CC3)C2)c2cc(C(F)(F)F)ccc2n1,Bioorg Med Chem Lett,CHEMBL2315940,35.1,No,4.454692884
CHEMBL2320519,Inhibition of human ERG assessed as [3H]astemizole binding activity,O=C(CNc1cc(C(F)(F)F)nc2ccc(C(F)(F)F)cc12)NC1CN([C@H]2CC[C@@](O)(c3cncs3)CC2)C1,Bioorg Med Chem Lett,CHEMBL2315939,36.1,No,4.442492798
CHEMBL2320519,Inhibition of human ERG assessed as [3H]astemizole binding activity,O=C(CNc1nc(C(F)(F)F)nc2ccc(C(F)(F)F)cc12)NC1CN([C@H]2CC[C@@](O)(c3cncs3)CC2)C1,Bioorg Med Chem Lett,CHEMBL2315938,32.7,No,4.485452247
CHEMBL2320519,Inhibition of human ERG assessed as [3H]astemizole binding activity,Nc1cnccc1[C@H]1CC[C@@H](N2CC(NC(=O)CNc3ncnc4ccc(C(F)(F)F)cc34)C2)CC1,Bioorg Med Chem Lett,CHEMBL2315929,46,No,4.337242168
CHEMBL2320519,Inhibition of human ERG assessed as [3H]astemizole binding activity,CC(C)c1ncc([C@]2(O)CC[C@H](N3CC(NC(=O)CNc4ncnc5ccc(C(F)(F)F)cc45)C3)CC2)s1,Bioorg Med Chem Lett,CHEMBL2315926,37.5,No,4.425968732
CHEMBL2318190,Binding affinity to human ERG,COC1COCCC1N[C@@H]1C[C@H]2CCC[C@@]2(C(=O)N2CCc3ccc(C#N)cc3C2)C1,Bioorg Med Chem Lett,CHEMBL2313767,33.7,No,4.472370099
CHEMBL2318190,Binding affinity to human ERG,COC1COCCC1N[C@@H]1C[C@H]2CCC[C@@]2(C(=O)N2CCc3ccc(Cl)cc3C2)C1,Bioorg Med Chem Lett,CHEMBL2314052,42.4,No,4.372634143
CHEMBL2318190,Binding affinity to human ERG,COC1COCCC1N[C@@H]1C[C@H]2CCC[C@@]2(C(=O)N2CCc3ncc(OC(C)C)cc3C2)C1,Bioorg Med Chem Lett,CHEMBL2314050,46.9,No,4.328827157
CHEMBL2318190,Binding affinity to human ERG,COc1cnc2c(c1)CN(C(=O)[C@@]13CCC[C@@H]1C[C@@H](NC1CCOCC1OC)C3)CC2,Bioorg Med Chem Lett,CHEMBL2313786,46.6,No,4.331614083
CHEMBL2318190,Binding affinity to human ERG,COC1COCCC1N[C@@H]1C[C@H]2CCC[C@@]2(C(=O)N2CCc3ncc(Br)cc3C2)C1,Bioorg Med Chem Lett,CHEMBL2313783,48.9,No,4.310691141
CHEMBL2318190,Binding affinity to human ERG,COC1COCCC1N[C@@H]1C[C@H]2CCC[C@@]2(C(=O)N2CCc3ncc(Cl)cc3C2)C1,Bioorg Med Chem Lett,CHEMBL2313782,33.3,No,4.477555766
CHEMBL2318190,Binding affinity to human ERG,COC1COCCC1N[C@@H]1C[C@H]2CCCC[C@@]2(C(=O)N2CCc3ncc(C(F)(F)F)cc3C2)C1,Bioorg Med Chem Lett,CHEMBL2314065,40.9,No,4.388276692
CHEMBL2318190,Binding affinity to human ERG,O=C(N1CCc2ncc(C(F)(F)F)cc2C1)[C@@]12CCCC[C@@H]1C[C@@H](NC1CCOCC1)C2,Bioorg Med Chem Lett,CHEMBL2314064,38.9,No,4.410050399
CHEMBL2318190,Binding affinity to human ERG,O=C(N1CCc2ncc(C(F)(F)F)cc2C1)[C@@]12CCC[C@@H]1C[C@@H](NCC1CCOCC1)C2,Bioorg Med Chem Lett,CHEMBL2314062,47,No,4.327902142
CHEMBL2318190,Binding affinity to human ERG,O=C(N1CCc2ncc(C(F)(F)F)cc2C1)[C@@]12CCC[C@@H]1C[C@@H](NC1CCCCC1)C2,Bioorg Med Chem Lett,CHEMBL2314057,33.6,No,4.473660723
CHEMBL2318190,Binding affinity to human ERG,O=C(N1CCc2ncc(C(F)(F)F)cc2C1)[C@@]12CCC[C@@H]1C[C@@H](NC1CCCC1)C2,Bioorg Med Chem Lett,CHEMBL2314056,33.5,No,4.474955193
CHEMBL2330743,Inhibition of human ERG K+ channel expressed in HEK293 cells after 15 mins by patch clamp assay,Cc1ccc(OCCCc2cccc(CCCOc3ccc(C)cc3)[n+]2C)cc1,J Med Chem,CHEMBL2325205,0.962,Yes,6.016824928
CHEMBL2330743,Inhibition of human ERG K+ channel expressed in HEK293 cells after 15 mins by patch clamp assay,Cc1ccc(C#CCOCc2cccc(COCC#Cc3ccc(C)cc3)[n+]2C)cc1,J Med Chem,CHEMBL2325200,0.214,Yes,6.669586227
CHEMBL2330743,Inhibition of human ERG K+ channel expressed in HEK293 cells after 15 mins by patch clamp assay,Cc1ccc(CCCOCc2cccc(COCCCc3ccc(C)cc3)[n+]2C)cc1,J Med Chem,CHEMBL2325199,0.194,Yes,6.71219827
CHEMBL2330743,Inhibition of human ERG K+ channel expressed in HEK293 cells after 15 mins by patch clamp assay,Cc1ccc(OCCCc2cc(N)cc(CCCOc3ccc(C)cc3)n2)cc1,J Med Chem,CHEMBL2324256,0.146,Yes,6.835647144
CHEMBL2330781,Displacement of [3H]astemizole from human ERG K+ channel expressed in HEK293 cells by scintillation spectrophotometric analysis,C[n+]1c(CCc2ccccc2)cccc1CCc1ccccc1,J Med Chem,CHEMBL2324251,0.466,Yes,6.331614083
CHEMBL2330781,Displacement of [3H]astemizole from human ERG K+ channel expressed in HEK293 cells by scintillation spectrophotometric analysis,C[n+]1c(COc2ccccc2)cccc1COc1ccccc1,J Med Chem,CHEMBL2324248,0.767,Yes,6.115204636
CHEMBL2330781,Displacement of [3H]astemizole from human ERG K+ channel expressed in HEK293 cells by scintillation spectrophotometric analysis,c1ccc(OCc2cccc(COc3ccccc3)n2)cc1,J Med Chem,CHEMBL2324247,0.074,Yes,7.13076828
CHEMBL2330781,Displacement of [3H]astemizole from human ERG K+ channel expressed in HEK293 cells by scintillation spectrophotometric analysis,C[n+]1c(CCCOc2ccccc2Cl)cccc1CCCOc1ccccc1Cl,J Med Chem,CHEMBL2324246,0.074,Yes,7.13076828
CHEMBL2330781,Displacement of [3H]astemizole from human ERG K+ channel expressed in HEK293 cells by scintillation spectrophotometric analysis,C[n+]1c(CCCOc2cccc(Cl)c2)cccc1CCCOc1cccc(Cl)c1,J Med Chem,CHEMBL2324245,0.06,Yes,7.22184875
CHEMBL2330781,Displacement of [3H]astemizole from human ERG K+ channel expressed in HEK293 cells by scintillation spectrophotometric analysis,C[n+]1c(CCCOc2ccc(Cl)cc2)cccc1CCCOc1ccc(Cl)cc1,J Med Chem,CHEMBL2324244,0.014,Yes,7.853871964
CHEMBL2330781,Displacement of [3H]astemizole from human ERG K+ channel expressed in HEK293 cells by scintillation spectrophotometric analysis,COc1ccc(OCCCc2cccc(CCCOc3ccc(OC)cc3)[n+]2C)cc1,J Med Chem,CHEMBL2324243,0.158,Yes,6.801342913
CHEMBL2330781,Displacement of [3H]astemizole from human ERG K+ channel expressed in HEK293 cells by scintillation spectrophotometric analysis,C[n+]1c(CCCOc2ccccc2)cccc1CCCOc1ccccc1,J Med Chem,CHEMBL2324242,0.208,Yes,6.681936665
CHEMBL2330781,Displacement of [3H]astemizole from human ERG K+ channel expressed in HEK293 cells by scintillation spectrophotometric analysis,C[n+]1c(C#CCOc2ccc(Cl)cc2)cccc1C#CCOc1ccc(Cl)cc1,J Med Chem,CHEMBL2324239,31.077,No,4.507560912
CHEMBL2330781,Displacement of [3H]astemizole from human ERG K+ channel expressed in HEK293 cells by scintillation spectrophotometric analysis,COc1ccc(C#Cc2cccc(C#Cc3ccc(OC)cc3)[n+]2C)cc1,J Med Chem,CHEMBL2325213,0.377,Yes,6.42365865
CHEMBL2330781,Displacement of [3H]astemizole from human ERG K+ channel expressed in HEK293 cells by scintillation spectrophotometric analysis,C[n+]1c(C#Cc2ccc(-c3ccccc3)cc2)cccc1C#Cc1ccc(-c2ccccc2)cc1,J Med Chem,CHEMBL2325212,0.294,Yes,6.53165267
CHEMBL2330781,Displacement of [3H]astemizole from human ERG K+ channel expressed in HEK293 cells by scintillation spectrophotometric analysis,C[n+]1c(C#Cc2ccccc2)cccc1C#Cc1ccccc1,J Med Chem,CHEMBL2325210,0.554,Yes,6.256490235
CHEMBL2330781,Displacement of [3H]astemizole from human ERG K+ channel expressed in HEK293 cells by scintillation spectrophotometric analysis,CCCCCCCCc1cccc(CCCCCCCC)[n+]1C,J Med Chem,CHEMBL2325208,0.015,Yes,7.823908741
CHEMBL2330781,Displacement of [3H]astemizole from human ERG K+ channel expressed in HEK293 cells by scintillation spectrophotometric analysis,Cc1ccc(CCOCCCc2cccc(CCCOCCc3ccc(C)cc3)[n+]2C)cc1,J Med Chem,CHEMBL2325206,0.371,Yes,6.43062609
CHEMBL2330781,Displacement of [3H]astemizole from human ERG K+ channel expressed in HEK293 cells by scintillation spectrophotometric analysis,Cc1ccc(OCCCc2cccc(CCCOc3ccc(C)cc3)[n+]2C)cc1,J Med Chem,CHEMBL2325205,0.086,Yes,7.065501549
CHEMBL2330781,Displacement of [3H]astemizole from human ERG K+ channel expressed in HEK293 cells by scintillation spectrophotometric analysis,Cc1ccc(CCc2cccc(CCc3ccc(C)cc3)[n+]2C)cc1,J Med Chem,CHEMBL2325204,0.024,Yes,7.619788758
CHEMBL2330781,Displacement of [3H]astemizole from human ERG K+ channel expressed in HEK293 cells by scintillation spectrophotometric analysis,Cc1ccc(C#Cc2cccc(C#Cc3ccc(C)cc3)[n+]2C)cc1,J Med Chem,CHEMBL2325201,0.285,Yes,6.54515514
CHEMBL2330781,Displacement of [3H]astemizole from human ERG K+ channel expressed in HEK293 cells by scintillation spectrophotometric analysis,Cc1ccc(C#CCOCc2cccc(COCC#Cc3ccc(C)cc3)[n+]2C)cc1,J Med Chem,CHEMBL2325200,0.04,Yes,7.397940009
CHEMBL2330781,Displacement of [3H]astemizole from human ERG K+ channel expressed in HEK293 cells by scintillation spectrophotometric analysis,Cc1ccc(CCCOCc2cccc(COCCCc3ccc(C)cc3)[n+]2C)cc1,J Med Chem,CHEMBL2325199,0.024,Yes,7.619788758
CHEMBL2330781,Displacement of [3H]astemizole from human ERG K+ channel expressed in HEK293 cells by scintillation spectrophotometric analysis,Cc1ccc(CCOCc2cccc(COCCc3ccc(C)cc3)[n+]2C)cc1,J Med Chem,CHEMBL2324264,0.135,Yes,6.869666232
CHEMBL2330781,Displacement of [3H]astemizole from human ERG K+ channel expressed in HEK293 cells by scintillation spectrophotometric analysis,Cc1ccc(COCc2cccc(COCc3ccc(C)cc3)[n+]2C)cc1,J Med Chem,CHEMBL2324263,0.107,Yes,6.970616222
CHEMBL2330781,Displacement of [3H]astemizole from human ERG K+ channel expressed in HEK293 cells by scintillation spectrophotometric analysis,Cc1ccc(OCc2cccc(COc3ccc(C)cc3)[n+]2C)cc1,J Med Chem,CHEMBL2324262,0.053,Yes,7.27572413
CHEMBL2330781,Displacement of [3H]astemizole from human ERG K+ channel expressed in HEK293 cells by scintillation spectrophotometric analysis,Cc1ccc(Cc2cc[n+](C)c(COc3ccc(C)cc3)c2)cc1.O=S(=O)([O-])C(F)(F)F,J Med Chem,CHEMBL2324261,0.346,Yes,6.460923901
CHEMBL2330781,Displacement of [3H]astemizole from human ERG K+ channel expressed in HEK293 cells by scintillation spectrophotometric analysis,Clc1ccc(OCCCc2cccc(CCCOc3ccc(Cl)cc3)n2)cc1,J Med Chem,CHEMBL2324257,0.0099,Yes,8.004364805
CHEMBL2330781,Displacement of [3H]astemizole from human ERG K+ channel expressed in HEK293 cells by scintillation spectrophotometric analysis,Cc1ccc(OCCCc2cc(N)cc(CCCOc3ccc(C)cc3)n2)cc1,J Med Chem,CHEMBL2324256,0.17,Yes,6.769551079
CHEMBL2330781,Displacement of [3H]astemizole from human ERG K+ channel expressed in HEK293 cells by scintillation spectrophotometric analysis,Cc1ccc(CCN(C)CCOc2ccc(C)cc2)cc1,J Med Chem,CHEMBL2324254,0.0051,Yes,8.292429824
CHEMBL2330781,Displacement of [3H]astemizole from human ERG K+ channel expressed in HEK293 cells by scintillation spectrophotometric analysis,CN(CCOc1ccc(NS(C)(=O)=O)cc1)CCc1ccc(NS(C)(=O)=O)cc1,J Med Chem,CHEMBL473,0.0041,Yes,8.387216143
CHEMBL2327767,Inhibition of human hERG by automated patch clamp assay,CC(C#N)=C1CCN(c2ccc(N3C[C@H](Cn4ccnn4)OC3=O)cc2F)CC1,Bioorg Med Chem Lett,CHEMBL2324519,213.32,No,3.670968425
CHEMBL2327767,Inhibition of human hERG by automated patch clamp assay,N#CC=C1CCN(c2ccc(N3C[C@H](Cn4ccnn4)OC3=O)cc2F)CC1,Bioorg Med Chem Lett,CHEMBL2324510,49.5,No,4.305394801
CHEMBL2330583,Inhibition of human ERG by whole-cell electrophysiology assay,C[C@@H]1COCCN1c1cc(C2(S(C)(=O)=O)CC2)nc(-c2cccc3[nH]ccc23)n1,J Med Chem,CHEMBL2325697,50,No,4.301029996
CHEMBL2330875,Inhibition of human ERG expressed in CHO cells by ionworks assay,NC1(C(=O)NC(CCCO)c2ccc(Cl)cc2)CCN(c2ncnc3[nH]ccc23)CC1,J Med Chem,CHEMBL2325739,57.793,No,4.238124761
CHEMBL2330875,Inhibition of human ERG expressed in CHO cells by ionworks assay,CS(=O)(=O)NCCC(NC(=O)C1(N)CCN(c2ncnc3[nH]ccc23)CC1)c1ccc(Cl)cc1,J Med Chem,CHEMBL2325736,80.124,No,4.096237378
CHEMBL2330875,Inhibition of human ERG expressed in CHO cells by ionworks assay,NC1(C(=O)NC(CCCN2CCOCC2)c2ccc(Cl)cc2)CCN(c2ncnc3[nH]ccc23)CC1,J Med Chem,CHEMBL2325995,74.807,No,4.126057762
CHEMBL2342727,Inhibition of human ERG,CC1CC1c1cc(C(F)(F)F)cc(COCC2(c3ccc(F)cc3)CCN(C)CC2)n1,Bioorg Med Chem Lett,CHEMBL2333606,34,No,4.468521083
CHEMBL2342727,Inhibition of human ERG,CN1CCC(COCc2cc(C(F)(F)F)cc(C#N)n2)(c2ccccc2)CC1,Bioorg Med Chem Lett,CHEMBL2333631,33,No,4.48148606
CHEMBL2342727,Inhibition of human ERG,CCNc1cc(C(F)(F)F)cc(COCC2(c3ccc(F)cc3)CCN(C)CC2)n1,Bioorg Med Chem Lett,CHEMBL2333619,80,No,4.096910013
CHEMBL2342727,Inhibition of human ERG,Clc1cc(COCC2(c3ccccc3)CCNCC2)cc(Cl)n1,Bioorg Med Chem Lett,CHEMBL2333647,33,No,4.48148606
CHEMBL2342727,Inhibition of human ERG,CN1CCC(COCc2cc(C(F)(F)F)cc(Cl)n2)(c2ccccc2F)CC1,Bioorg Med Chem Lett,CHEMBL2333644,43,No,4.366531544
CHEMBL2343015,Inhibition of human ERG assessed as decrease in tail current amplitude measured after 5 mins by whole cell patch clamp technique,CCOC(=O)N1CCC(CN2CC[C@H](N3C(=O)Cc4ccccc43)C2)CC1,ACS Med Chem Lett,CHEMBL2336055,0.8,Yes,6.096910013
CHEMBL2346000,Inhibition of human ERG channel,CS(=O)(=O)c1ccc([C@@H](CC2CCCC2)C(=O)Nc2cnc([C@H](O)CO)cn2)cc1Cl,ACS Med Chem Lett,CHEMBL2338347,70,No,4.15490196
CHEMBL2338825,Inhibition of human ERG,CNC(=O)c1cccc(-c2ccc3c(N4CCOC[C@@H]4C)nc(N4CCOC[C@@H]4C)nc3n2)c1,Bioorg Med Chem Lett,CHEMBL2336325,47.5,No,4.32330639
CHEMBL2338825,Inhibition of human ERG,COc1ccc(-c2ccc3c(N4CCOC[C@@H]4C)nc(N4CCOC[C@@H]4C)nc3n2)cc1CO,Bioorg Med Chem Lett,CHEMBL1801204,30.4,No,4.517126416
CHEMBL2339143,Inhibition of human ERG,O[C@H](COc1ccc(F)cc1)CN1CCN(Cc2ccc(Cl)c(Cl)c2)CC1,Bioorg Med Chem Lett,CHEMBL2334265,0.29,Yes,6.537602002
CHEMBL2339143,Inhibition of human ERG,O[C@H](COc1ccc(Cl)cc1)CN1CCN(Cc2ccc(Cl)cc2)CC1,Bioorg Med Chem Lett,CHEMBL2334618,0.32,Yes,6.494850022
CHEMBL2339143,Inhibition of human ERG,O[C@@H](COc1ccc(F)cc1)CN1CCN(Cc2ccc(Cl)c(Cl)c2)CC1,Bioorg Med Chem Lett,CHEMBL2334601,0.87,Yes,6.060480747
CHEMBL2345730,Inhibition of human ERG,COc1cccc2nc(C#Cc3cccnc3)ccc12,Bioorg Med Chem Lett,CHEMBL2335285,65.3,No,4.185086819
CHEMBL2345730,Inhibition of human ERG,COc1cccc2nc(C#Cc3ccccc3)ccc12,Bioorg Med Chem Lett,CHEMBL2335279,61.7,No,4.209714836
CHEMBL2350555,Inhibition of human ERG channel,CC(C)(C)NC(=O)c1c[nH]c2ncc(-c3nn(CCCS(C)(=O)=O)c4ccc(OC(F)F)cc34)nc12,J Med Chem,CHEMBL2347420,0.429,Yes,6.367542708
CHEMBL2350555,Inhibition of human ERG channel,CC(C)(C)NC(=O)c1c[nH]c2ncc(-c3nn(CCCN4CC(C#N)C4)c4ccc(OC(F)F)cc34)nc12,J Med Chem,CHEMBL2347417,0.414,Yes,6.382999659
CHEMBL2350555,Inhibition of human ERG channel,CN1CC(Cn2nc(-c3cnc4[nH]cc(C(=O)NC(C)(C)C)c4n3)c3cc(OC(F)F)ccc32)C1,J Med Chem,CHEMBL2347416,0.293,Yes,6.53313238
CHEMBL2352672,Inhibition of human ERG by IonWorks assay,OC1(c2cccnc2)CCN(c2ccc3nnc(C(F)(F)F)n3n2)CC1,Bioorg Med Chem Lett,CHEMBL2346971,95.49926,No,4.019999994
CHEMBL2384768,Inhibition of human ERG channel in HEK293 cells by voltage-gated patch clamp technique,COc1ccc2nccc([C@@H](O)CC[C@@H]3CCN(C4CC(c5cc(F)cc(F)c5F)C4)C[C@@H]3C(=O)O)c2c1,Bioorg Med Chem Lett,CHEMBL2382372,30.9,No,4.510041521
CHEMBL2384768,Inhibition of human ERG channel in HEK293 cells by voltage-gated patch clamp technique,COc1ccc2nccc([C@@H](O)CC[C@@H]3CCN(C4CC(c5c(F)cccc5F)C4)C[C@@H]3C(=O)O)c2c1,Bioorg Med Chem Lett,CHEMBL2382343,47.6,No,4.322393047
CHEMBL2390223,Inhibition of human ERG expressed in HEK293 cells by electrophysiology assay,Cc1c(C)c2ccc(OCCCCN3CCC(c4noc5cc(F)ccc45)CC3)cc2oc1=O,J Med Chem,CHEMBL2385102,0.195,Yes,6.709965389
CHEMBL2390223,Inhibition of human ERG expressed in HEK293 cells by electrophysiology assay,Cc1cc(=O)oc2c(C)c(OCCCCN3CCC(c4noc5cc(F)ccc45)CC3)ccc12,J Med Chem,CHEMBL2387230,0.226,Yes,6.645891561
CHEMBL2390223,Inhibition of human ERG expressed in HEK293 cells by electrophysiology assay,O=c1cc(-c2ccccc2)c2ccc(OCCCCN3CCC(c4noc5cc(F)ccc45)CC3)cc2o1,J Med Chem,CHEMBL2387265,0.82,Yes,6.086186148
CHEMBL2390223,Inhibition of human ERG expressed in HEK293 cells by electrophysiology assay,COc1ccccc1N1CCN(CCCCOc2ccc3c(C)cc(=O)oc3c2)CC1,J Med Chem,CHEMBL2387253,0.031,Yes,7.508638306
CHEMBL2390223,Inhibition of human ERG expressed in HEK293 cells by electrophysiology assay,Cc1cc(=O)oc2cc(OCCCCN3CCC(c4noc5cc(F)ccc45)CC3)ccc12,J Med Chem,CHEMBL2387260,0.159,Yes,6.798602876
CHEMBL2390223,Inhibition of human ERG expressed in HEK293 cells by electrophysiology assay,Cc1nc2n(c(=O)c1CCN1CCC(c3noc4cc(F)ccc34)CC1)CCCC2,J Med Chem,CHEMBL85,0.581,Yes,6.235823868
CHEMBL2390223,Inhibition of human ERG expressed in HEK293 cells by electrophysiology assay,CN1CCN(C2=Nc3cc(Cl)ccc3Nc3ccccc32)CC1,J Med Chem,CHEMBL42,0.65,Yes,6.187086643
CHEMBL2388893,Inhibition of human ERG,CN(C)C(=O)[C@H]1C[C@@H]1c1ccc(-c2ncn(C)c2Sc2ccc(Cl)cn2)cc1,ACS Med Chem Lett,CHEMBL2386558,37,No,4.431798276
CHEMBL2394849,Inhibition of human ERG channel,Cc1cc(N2CCC(N3CCCC3C)C2)ccc1NC(=O)c1cc(F)ccc1C,Bioorg Med Chem Lett,CHEMBL2391167,0.48,Yes,6.318758763
CHEMBL2395084,Displacement of [3H]Astemizole from human recombinant ERG expressed in HEK293 cells at after 60 mins,COc1ccc(CCN2CCC(Nc3nc4ccccc4n3Cc3ccc(F)cc3)CC2)cc1,Bioorg Med Chem Lett,CHEMBL296419,0.0026,Yes,8.585026652
CHEMBL2396019,Inhibition of human ERG expressed in HEK cells by ion flux electrophysiology method,O=C(c1ccc(F)cc1OC[C@@H](O)CN1CCC2(CC1)Cc1cc(Cl)ccc1O2)N1CC[C@H](O)C1,Bioorg Med Chem Lett,CHEMBL2391800,0.7,Yes,6.15490196
CHEMBL2396019,Inhibition of human ERG expressed in HEK cells by ion flux electrophysiology method,O=C(NC1CC1)c1ccc(O)cc1OC[C@@H](O)CN1CCC2(CC1)Cc1cc(Cl)ccc1O2,Bioorg Med Chem Lett,CHEMBL2391795,0.3,Yes,6.522878745
CHEMBL2396019,Inhibition of human ERG expressed in HEK cells by ion flux electrophysiology method,O=C(NC1CC1)c1ccc(F)cc1OC[C@@H](O)CN1CCC2(CC1)Cc1cc(Cl)ccc1O2,Bioorg Med Chem Lett,CHEMBL2391939,0.038,Yes,7.420216403
CHEMBL2395380,Inhibition of human ERG expressed in HEK293 cells by whole-cell patch-clamp technique,CC(C)(C(=O)O)c1ccc(CN2CCC(COC(=O)c3c4n(c5ccccc35)CCCO4)CC2)cc1,Eur J Med Chem,CHEMBL2391994,69,No,4.161150909
CHEMBL2400450,Inhibition of human ERG current by patch clamp assay,COc1c(N2CCNC(C)C2)c(F)cc2c(=O)c(C(=O)O)cn(C3CC3)c12,Bioorg Med Chem Lett,CHEMBL31,130,No,3.886056648
CHEMBL2400450,Inhibition of human ERG current by patch clamp assay,CC1COc2c(N3CCN(C)CC3)c(F)cc3c(=O)c(C(=O)O)cn1c23,Bioorg Med Chem Lett,CHEMBL4,1420,No,2.847711656
CHEMBL2400450,Inhibition of human ERG current by patch clamp assay,O=C(O)c1cn(C2CC2)c2cc(N3CCNCC3)c(F)cc2c1=O,Bioorg Med Chem Lett,CHEMBL8,966,No,3.015022874
CHEMBL2400450,Inhibition of human ERG current by patch clamp assay,COc1c(N2C[C@@H]3CCCN[C@@H]3C2)c(F)cc2c(=O)c(C(=O)O)cn(C3CC3)c12,Bioorg Med Chem Lett,CHEMBL32,129,No,3.88941029
CHEMBL2400450,Inhibition of human ERG current by patch clamp assay,C[C@H]1COc2c(N3CCN(C)CC3)c(F)cc3c(=O)c(C(=O)O)cn1c23,Bioorg Med Chem Lett,CHEMBL33,915,No,3.038578906
CHEMBL2400450,Inhibition of human ERG current by patch clamp assay,Cc1c(F)c(N2CCNC(C)C2)cc2c1c(=O)c(C(=O)O)cn2C1CC1,Bioorg Med Chem Lett,CHEMBL583,50,No,4.301029996
CHEMBL2400452,Binding affinity to human ERG F656A tandem dimeric mutant expressed in HEK293 cells assessed as inhibition of tail current measured upon repolarization to -120 mV by patch clamp method,C[C@@H]1CN(c2c(F)c(N)c3c(=O)c(C(=O)O)cn(C4CC4)c3c2F)C[C@H](C)N1,Bioorg Med Chem Lett,CHEMBL850,33.6,No,4.473660723
CHEMBL2400452,Binding affinity to human ERG F656A tandem dimeric mutant expressed in HEK293 cells assessed as inhibition of tail current measured upon repolarization to -120 mV by patch clamp method,C[C@H]1COc2c(N3CCN(C)CC3)c(F)cc3c(=O)c(C(=O)O)cn1c23,Bioorg Med Chem Lett,CHEMBL33,2300,No,2.638272164
CHEMBL2400453,Binding affinity to human ERG S624A tetrameric mutant expressed in HEK293 cells assessed as inhibition of tail current measured upon repolarization to -40 mV by patch clamp method,C[C@@H]1CN(c2c(F)c(N)c3c(=O)c(C(=O)O)cn(C4CC4)c3c2F)C[C@H](C)N1,Bioorg Med Chem Lett,CHEMBL850,46.9,No,4.328827157
CHEMBL2400453,Binding affinity to human ERG S624A tetrameric mutant expressed in HEK293 cells assessed as inhibition of tail current measured upon repolarization to -40 mV by patch clamp method,C[C@H]1COc2c(N3CCN(C)CC3)c(F)cc3c(=O)c(C(=O)O)cn1c23,Bioorg Med Chem Lett,CHEMBL33,2100,No,2.677780705
CHEMBL2400455,Binding affinity to human ERG Y652A tandem dimeric mutant expressed in HEK293 cells assessed as inhibition of tail current measured upon repolarization to -40 mV by patch clamp method,C[C@@H]1CN(c2c(F)c(N)c3c(=O)c(C(=O)O)cn(C4CC4)c3c2F)C[C@H](C)N1,Bioorg Med Chem Lett,CHEMBL850,127.6,No,3.894149326
CHEMBL2400455,Binding affinity to human ERG Y652A tandem dimeric mutant expressed in HEK293 cells assessed as inhibition of tail current measured upon repolarization to -40 mV by patch clamp method,C[C@H]1COc2c(N3CCN(C)CC3)c(F)cc3c(=O)c(C(=O)O)cn1c23,Bioorg Med Chem Lett,CHEMBL33,2300,No,2.638272164
CHEMBL2400456,Binding affinity to wild type human ERG expressed in HEK293 cells assessed as inhibition of tail current measured upon repolarization to -40 mV by patch clamp method,C[C@H]1COc2c(N3CCN(C)CC3)c(F)cc3c(=O)c(C(=O)O)cn1c23,Bioorg Med Chem Lett,CHEMBL33,1100,No,2.958607315
CHEMBL2406353,Inhibition of human ERG by patch-clamp technique,Cc1cc(Nc2ncc(Cl)c(Nc3ccccc3S(=O)(=O)C(C)C)n2)c(OC(C)C)cc1C1CCNCC1,J Med Chem,CHEMBL2403108,46,No,4.337242168
CHEMBL2406355,Inhibition of human ERG by dofetilide binding assay,CC(C)Oc1nc(C2CCNCC2)ncc1Nc1ncc(Cl)c(Nc2ccccc2S(=O)(=O)C(C)C)n1,J Med Chem,CHEMBL2403831,0.4,Yes,6.397940009
CHEMBL2406366,Inhibition of human ERG channel by patch clamp technique,Cc1nc2cc(F)ccc2n1[C@H]1CC[C@@H](NC[C@H]2Cc3ccc(C#N)cc3C2)CC1,Bioorg Med Chem Lett,CHEMBL2403866,0.03,Yes,7.522878745
CHEMBL2406366,Inhibition of human ERG channel by patch clamp technique,CC(C)(O)c1nc2cc(Cl)ccc2n1[C@H]1CC[C@@H](NC[C@H]2Cc3ccc(C#N)cc3C2)CC1,Bioorg Med Chem Lett,CHEMBL2403861,0.06,Yes,7.22184875
CHEMBL2406366,Inhibition of human ERG channel by patch clamp technique,CC(C)(O)c1nc2cc(Cl)ccc2n1[C@H]1CC[C@@H](NCC2Cc3ccc(Cl)cc3C2)CC1,Bioorg Med Chem Lett,CHEMBL2403858,0.42,Yes,6.37675071
CHEMBL2406416,Inhibition of human ERG by patch clamp method,Cc1cc(Nc2ncc(Cl)c(Nc3ccccc3S(=O)(=O)C(C)C)n2)c(OC(C)C)cc1C1CCNCC1,J Med Chem,CHEMBL2403108,46,No,4.337242168
CHEMBL2410296,Inhibition of human ERG channel by electrophysiological assay,C[C@]1(CS(=O)(=O)N2CCN(c3ncc(OCc4ccc(C(F)(F)F)o4)cn3)CC2)NC(=O)NC1=O,Bioorg Med Chem Lett,CHEMBL2409676,44,No,4.356547324
CHEMBL2410296,Inhibition of human ERG channel by electrophysiological assay,C[C@]1(CS(=O)(=O)N2CCC(Oc3ccc(OC(F)(F)C(F)F)cc3)CC2)NC(=O)NC1=O,Bioorg Med Chem Lett,CHEMBL2409707,40,No,4.397940009
CHEMBL2411862,Inhibition of human ERG by automated planar patch-clamp system,CCCN1C(=O)CC2(CCN(CC3CCN(C(=O)OCC)CC3)CC2)c2cccnc21,Bioorg Med Chem Lett,CHEMBL2407175,0.67,Yes,6.173925197
CHEMBL2411862,Inhibition of human ERG by automated planar patch-clamp system,CCOC(=O)N1CCC(CN2CCC3(CC2)OC(=O)Nc2ncccc23)CC1,Bioorg Med Chem Lett,CHEMBL2407171,0.92,Yes,6.036212173
CHEMBL2417298,Binding affinity to human ERG,COc1cc(-c2nc3n(n2)CCC[C@@H]3c2ccc(F)cc2C)ccc1-n1cnc(C)c1,Bioorg Med Chem Lett,CHEMBL2415096,0.794,Yes,6.100179498
CHEMBL2424274,Displacement of [3H]dofetilide from human ERG channel,CNCc1cc(-c2cn(C)nc2-c2ccc(F)cc2)ccn1,J Med Chem,CHEMBL2420702,38.2,No,4.417936637
CHEMBL2429187,Inhibition of human ERG,CC#CCn1c(N2CCC[C@@H](N)C2)cc(=O)n(Cc2ccc3ccc(Cl)cc3n2)c1=O,Eur J Med Chem,CHEMBL2425893,100,No,4
CHEMBL2427860,Inhibition of human ERG transfected in HEK293 cells by patch clamp assay,O=c1cnc2ccc(F)c3c2n1C[C@@]3(O)CN1CCC(NCc2cc3c(cn2)OCCO3)CC1,Bioorg Med Chem Lett,CHEMBL2424933,206,No,3.68613278
CHEMBL2427860,Inhibition of human ERG transfected in HEK293 cells by patch clamp assay,O=c1ccc2ncc(F)c3c2n1C[C@H]3CN1CCC(NCc2cc3c(cn2)OCCO3)CC1,Bioorg Med Chem Lett,CHEMBL2424931,122,No,3.913640169
CHEMBL2427860,Inhibition of human ERG transfected in HEK293 cells by patch clamp assay,O=c1ccc2ncc(F)c3c2n1C[C@@]3(O)CN1CCC(NCc2cc3c(cn2)OCCO3)CC1,Bioorg Med Chem Lett,CHEMBL2424928,310,No,3.508638306
CHEMBL2427861,Inhibition of human ERG by patch clamp assay,O=c1c(F)cc2ncc(F)c3c2n1C[C@@]3(O)CN1CCC(NCc2cc3c(cn2)OCCO3)CC1,Bioorg Med Chem Lett,CHEMBL2424934,289,No,3.539102157
CHEMBL2427861,Inhibition of human ERG by patch clamp assay,O=c1cnc2ccc(F)c3c2n1C[C@@]3(O)CN1CCC(NCc2cc3c(cn2)OCCO3)CC1,Bioorg Med Chem Lett,CHEMBL2424933,101,No,3.995678626
CHEMBL2427861,Inhibition of human ERG by patch clamp assay,O=c1ccc2ncc(F)c3c2n1C[C@H]3CN1CCC(NCc2cc3c(cn2)OCCO3)CC1,Bioorg Med Chem Lett,CHEMBL2424931,58,No,4.236572006
CHEMBL2427861,Inhibition of human ERG by patch clamp assay,O=c1ccc2ncc(F)c3c2n1C[C@@]3(O)CN1CCC(NCc2cc3c(cn2)OCCO3)CC1,Bioorg Med Chem Lett,CHEMBL2424928,239,No,3.621602099
CHEMBL2439936,Inhibition of human ERG,CN[C@@H](C)C(=O)N[C@@H]1C(=O)N(Cc2c(C)ccc3ccccc23)c2ccc(C#N)cc2N(C(C)=O)[C@H]1C.Cl,J Med Chem,CHEMBL2436226,35.3,No,4.452225295
CHEMBL2444347,Inhibition of human ERG channel expressed in CHO cells by whole cell patch clamp technique,COc1ccc2c(c1)c(/C=N/NS(=O)(=O)c1ccc(C)cc1)cn2CC(=O)Nc1ccc(Cl)cc1,Bioorg Med Chem,CHEMBL2440387,418.35,No,3.378460227
CHEMBL2444347,Inhibition of human ERG channel expressed in CHO cells by whole cell patch clamp technique,Cc1ccc(S(=O)(=O)N/N=C/c2cn(CC(=O)Nc3ccc(F)cc3F)c3ccccc23)cc1,Bioorg Med Chem,CHEMBL2440384,42.97,No,4.366834646
CHEMBL2444347,Inhibition of human ERG channel expressed in CHO cells by whole cell patch clamp technique,Cc1ccc(S(=O)(=O)N/N=C/c2cn(CC(=O)Nc3ccccc3)c3ccccc23)cc1,Bioorg Med Chem,CHEMBL2440398,43.62,No,4.360314339
CHEMBL2443482,Displacement of [35S]-MK499 from human ERG,COc1c(CCN2CCN(C(=O)Cc3ccc(-n4cnnn4)cc3)CC2)ccc2c1COC2=O,Bioorg Med Chem Lett,CHEMBL2441422,40,No,4.397940009
CHEMBL2443482,Displacement of [35S]-MK499 from human ERG,O=C1OCc2c1ccc(CCN1CCN(C(=O)Cc3ccc(-n4cnnn4)cc3)CC1)c2F,Bioorg Med Chem Lett,CHEMBL2441420,31,No,4.508638306
CHEMBL2443482,Displacement of [35S]-MK499 from human ERG,O=C1OCCc2cc(CCN3CCN(C(=O)Cc4ccc(-n5cnnn5)cc4)CC3)ccc21,Bioorg Med Chem Lett,CHEMBL2441408,43,No,4.366531544
CHEMBL2443482,Displacement of [35S]-MK499 from human ERG,O=C1OCc2ccc(CCN3CCN(C(=O)Cc4ccc(-n5cnnn5)cc4)CC3)cc21,Bioorg Med Chem Lett,CHEMBL2441438,32,No,4.494850022
CHEMBL2443482,Displacement of [35S]-MK499 from human ERG,N#Cc1ccc(CCN2CCN(C(=O)Cc3ccc(-n4cnnn4)cc3)CC2)cc1,Bioorg Med Chem Lett,CHEMBL2441434,0.42,Yes,6.37675071
CHEMBL2443482,Displacement of [35S]-MK499 from human ERG,O=C(Cc1ccc(-n2cnnn2)cc1)N1CCN(CCc2ccc([N+](=O)[O-])cc2)CC1,Bioorg Med Chem Lett,CHEMBL2441433,0.16,Yes,6.795880017
CHEMBL2443482,Displacement of [35S]-MK499 from human ERG,O=C(Cc1ccc([N+](=O)[O-])cc1)N1CCN(CCc2ccc([N+](=O)[O-])cc2)CC1,Bioorg Med Chem Lett,CHEMBL2441430,0.046,Yes,7.337242168
CHEMBL2443482,Displacement of [35S]-MK499 from human ERG,O=[N+]([O-])c1ccc(CCN2CCN(CCc3ccc(-n4cnnn4)cc3)CC2)cc1,Bioorg Med Chem Lett,CHEMBL2441429,0.011,Yes,7.958607315
CHEMBL2447591,Inhibition of human ERG expressed in HEK293 cells by patch-clamp technique,CS(=O)(=O)O.O=C(O)c1ccccc1-c1ccc(CN2CCC(COC(=O)c3c4n(c5ccccc35)CCCO4)CC2)cc1,Bioorg Med Chem,CHEMBL2440460,47.5,No,4.32330639
CHEMBL2447591,Inhibition of human ERG expressed in HEK293 cells by patch-clamp technique,COC(=O)c1ccccc1-c1ccc(CN2CCC(COC(=O)c3c4n(c5ccccc35)CCCO4)CC2)cc1.CS(=O)(=O)O,Bioorg Med Chem,CHEMBL2440459,0.131,Yes,6.882728704
CHEMBL3090833,Inhibition of human ERG,CNCCC(Oc1ccc(C(F)(F)F)cc1)c1ccccc1,J Med Chem,CHEMBL41,0.01,Yes,8
CHEMBL3090833,Inhibition of human ERG,O=C(CCCN1CCC(O)(c2ccc(Cl)cc2)CC1)c1ccc(F)cc1,J Med Chem,CHEMBL54,0.01,Yes,8
CHEMBL3090833,Inhibition of human ERG,COc1ccc(CCN(C)CCCC(C#N)(c2ccc(OC)c(OC)c2)C(C)C)cc1OC,J Med Chem,CHEMBL6966,0.01,Yes,8
CHEMBL3090833,Inhibition of human ERG,CN(C)CCCC1(c2ccc(F)cc2)OCc2cc(C#N)ccc21,J Med Chem,CHEMBL549,0.01,Yes,8
CHEMBL3089256,Inhibition of human ERG current transfected in CHO cells by patch clamp assay,Cc1cc(N2CC[C@H](N3CCC[C@@H]3C)C2)ccc1NC(=O)c1c(C)noc1C,Bioorg Med Chem Lett,CHEMBL3087669,37,No,4.431798276
CHEMBL3090534,Inhibition of human ERG,CCN(CC)CC(=O)N[C@@H]1CC[C@@H](C(=O)NC(c2ccc(F)cc2)c2ccc(F)cc2)[C@H](c2ccc(Br)cc2)C1,Bioorg Med Chem Lett,CHEMBL3086028,0.78,Yes,6.107905397
CHEMBL3090534,Inhibition of human ERG,O=C(NC(c1ccc(Cl)cc1)c1ccc(F)cn1)[C@@H]1CC[C@@H](N2CCOCC2)C[C@H]1c1ccc(Br)cc1,Bioorg Med Chem Lett,CHEMBL3086041,0.18,Yes,6.744727495
CHEMBL3090534,Inhibition of human ERG,O=C(NC(c1ccc(Cl)cc1)c1ccnc(F)c1)[C@@H]1CC[C@@H](N2CCOCC2)C[C@H]1c1ccc(Br)cc1,Bioorg Med Chem Lett,CHEMBL3086040,0.59,Yes,6.229147988
CHEMBL3090534,Inhibition of human ERG,O=C(NC(c1ccc(Cl)cc1)c1ccncc1Cl)[C@@H]1CC[C@@H](N2CCOCC2)C[C@H]1c1ccc(Br)cc1,Bioorg Med Chem Lett,CHEMBL3086039,0.69,Yes,6.161150909
CHEMBL3090534,Inhibition of human ERG,O=C(NC(c1ccc(F)cc1)c1ccc(F)cc1)[C@@H]1CC[C@@H](N2CCOCC2)C[C@H]1c1ccc(Br)cc1,Bioorg Med Chem Lett,CHEMBL3086036,0.1,Yes,7
CHEMBL3090534,Inhibition of human ERG,O=C(NC(c1ccc(Cl)cc1)c1ccc(Cl)cc1)[C@@H]1CC[C@@H](N2CCOCC2)C[C@H]1c1ccc(Br)cc1,Bioorg Med Chem Lett,CHEMBL3086035,0.039,Yes,7.408935393
CHEMBL3090534,Inhibition of human ERG,O=C([C@@H]1CC[C@@H](N2CCOCC2)C[C@H]1c1ccc(Br)cc1)N1CC(c2ccccc2)(c2ccccc2)C1,Bioorg Med Chem Lett,CHEMBL3086029,0.29,Yes,6.537602002
CHEMBL3090534,Inhibition of human ERG,O=C(NC(c1ccccc1)c1ccccc1)[C@@H]1CC[C@@H](N2CCOCC2)C[C@H]1c1ccc(Br)cc1,Bioorg Med Chem Lett,CHEMBL3086048,0.53,Yes,6.27572413
CHEMBL3090534,Inhibition of human ERG,O=C(NC(c1ccccc1)c1ccccc1)[C@@H]1CC[C@@H](N2CCOCC2)C[C@H]1c1ccccc1,Bioorg Med Chem Lett,CHEMBL3086047,0.17,Yes,6.769551079
CHEMBL3090534,Inhibition of human ERG,Cc1ccccc1[C@H]1C[C@@H](NCc2ccc(Cl)cc2)CC[C@@H]1C(=O)N1CC(c2ccccc2)(c2ccccc2)C1,Bioorg Med Chem Lett,CHEMBL3086045,0.003,Yes,8.522878745
CHEMBL3096732,Displacement of [3H]astemizole from human ERG channel expressed in HEK293 cell membrane after 1 hr by scintillation counting analysis,CCCCCCCN(CC)CC#CCOC(c1ccccc1)c1ccccc1,J Med Chem,CHEMBL3093987,0.97,Yes,6.013228266
CHEMBL3096732,Displacement of [3H]astemizole from human ERG channel expressed in HEK293 cell membrane after 1 hr by scintillation counting analysis,CCCCCCCN(CC)CC#CCOCc1ccc(Cl)cc1,J Med Chem,CHEMBL3093950,0.834,Yes,6.078833949
CHEMBL3096731,Inhibition of human ERG channel expressed in HEK293 cells after 15 mins by whole-cell patch clamp technique,CCCCCCCN(CC)CCCCc1ccc(Cl)cc1,J Med Chem,CHEMBL3093959,0.0043,Yes,8.366531544
CHEMBL3096731,Inhibition of human ERG channel expressed in HEK293 cells after 15 mins by whole-cell patch clamp technique,CCCCCCCN(CC)CC#CCOc1ccc(Cl)cc1,J Med Chem,CHEMBL3093982,0.058,Yes,7.236572006
CHEMBL3096731,Inhibition of human ERG channel expressed in HEK293 cells after 15 mins by whole-cell patch clamp technique,CCCCN(CC)CC#CC#Cc1ccc(Cl)cc1,J Med Chem,CHEMBL3093979,0.473,Yes,6.325138859
CHEMBL3096731,Inhibition of human ERG channel expressed in HEK293 cells after 15 mins by whole-cell patch clamp technique,CCCCCCCN(CC)CC#CCCc1ccc(Cl)cc1,J Med Chem,CHEMBL3093976,0.053,Yes,7.27572413
CHEMBL3096731,Inhibition of human ERG channel expressed in HEK293 cells after 15 mins by whole-cell patch clamp technique,CCCCCCCN(CC)CC#CCc1ccc(Cl)cc1,J Med Chem,CHEMBL3093969,0.0049,Yes,8.30980392
CHEMBL3096731,Inhibition of human ERG channel expressed in HEK293 cells after 15 mins by whole-cell patch clamp technique,CCCCCCC[N+](CC)(CC)CCCCc1ccc(Cl)cc1.Cc1ccc(S(=O)(=O)[O-])cc1,J Med Chem,CHEMBL598270,0.05,Yes,7.301029996
CHEMBL3096732,Displacement of [3H]astemizole from human ERG channel expressed in HEK293 cell membrane after 1 hr by scintillation counting analysis,CCCCCCCN1CCC(C(=O)c2ccccc2)CC1,J Med Chem,CHEMBL3093963,0.124,Yes,6.906578315
CHEMBL3096732,Displacement of [3H]astemizole from human ERG channel expressed in HEK293 cell membrane after 1 hr by scintillation counting analysis,CCCCCCCN1CCC(Cc2ccccc2)CC1,J Med Chem,CHEMBL3093962,0.058,Yes,7.236572006
CHEMBL3096732,Displacement of [3H]astemizole from human ERG channel expressed in HEK293 cell membrane after 1 hr by scintillation counting analysis,CCCCCCCN(CC)CCCCCc1ccc(Cl)cc1,J Med Chem,CHEMBL3093961,0.123,Yes,6.910094889
CHEMBL3096732,Displacement of [3H]astemizole from human ERG channel expressed in HEK293 cell membrane after 1 hr by scintillation counting analysis,CCCCCCCN(CC)CCCCc1ccc(Cl)cc1,J Med Chem,CHEMBL3093959,0.043,Yes,7.366531544
CHEMBL3096732,Displacement of [3H]astemizole from human ERG channel expressed in HEK293 cell membrane after 1 hr by scintillation counting analysis,CCCCCCCN(CC)CCCCc1ccccc1,J Med Chem,CHEMBL3093958,0.506,Yes,6.295849483
CHEMBL3096732,Displacement of [3H]astemizole from human ERG channel expressed in HEK293 cell membrane after 1 hr by scintillation counting analysis,CCCCCCC[N+](CC)(CC)C/C=C/Cc1ccc(Cl)cc1.[I-],J Med Chem,CHEMBL3093957,0.0015,Yes,8.823908741
CHEMBL3096732,Displacement of [3H]astemizole from human ERG channel expressed in HEK293 cell membrane after 1 hr by scintillation counting analysis,CCCCCCCN(CC)C/C=C/CCc1ccc(Cl)cc1,J Med Chem,CHEMBL3093955,0.238,Yes,6.623423043
CHEMBL3096732,Displacement of [3H]astemizole from human ERG channel expressed in HEK293 cell membrane after 1 hr by scintillation counting analysis,CCCCCCCN(CC)C/C=C/Cc1ccccc1,J Med Chem,CHEMBL3093953,0.176,Yes,6.754487332
CHEMBL3096732,Displacement of [3H]astemizole from human ERG channel expressed in HEK293 cell membrane after 1 hr by scintillation counting analysis,CCCCCCCN(CC)C/C=C/Cc1ccc(Cl)cc1,J Med Chem,CHEMBL3093986,0.049,Yes,7.30980392
CHEMBL3096732,Displacement of [3H]astemizole from human ERG channel expressed in HEK293 cell membrane after 1 hr by scintillation counting analysis,CCCCCCCN(CC)C/C=C/c1ccc(Cl)cc1,J Med Chem,CHEMBL3093984,0.243,Yes,6.614393726
CHEMBL3096732,Displacement of [3H]astemizole from human ERG channel expressed in HEK293 cell membrane after 1 hr by scintillation counting analysis,CCCCCCCN(CC)CC#CCCc1ccc(Cl)cc1,J Med Chem,CHEMBL3093976,0.765,Yes,6.116338565
CHEMBL3096732,Displacement of [3H]astemizole from human ERG channel expressed in HEK293 cell membrane after 1 hr by scintillation counting analysis,CCCCCCCN(CC)CC#CC(c1ccccc1)c1ccccc1,J Med Chem,CHEMBL3093972,0.238,Yes,6.623423043
CHEMBL3096732,Displacement of [3H]astemizole from human ERG channel expressed in HEK293 cell membrane after 1 hr by scintillation counting analysis,CCCCCCCN(CC)CC#CCc1ccc(Cl)cc1,J Med Chem,CHEMBL3093969,0.865,Yes,6.062983893
CHEMBL3096732,Displacement of [3H]astemizole from human ERG channel expressed in HEK293 cell membrane after 1 hr by scintillation counting analysis,CCCCCCC[N+](CC)(CC)CC#Cc1ccc(Cl)cc1.Cc1ccc(S(=O)(=O)[O-])cc1,J Med Chem,CHEMBL3093965,0.04,Yes,7.397940009
CHEMBL3096732,Displacement of [3H]astemizole from human ERG channel expressed in HEK293 cell membrane after 1 hr by scintillation counting analysis,CCCCCCC[N+](CC)(CC)CCCCc1ccc(Cl)cc1.Cc1ccc(S(=O)(=O)[O-])cc1,J Med Chem,CHEMBL598270,0.002,Yes,8.698970004
CHEMBL3102091,Inhibition of human ERG expressed in HEK cells after 3 hrs by ion flux electrophysiology,NC(=O)Nc1ccc(F)cc1OC[C@@H](O)CN1CCC2(CC1)Cc1cc(Cl)ccc1O2,Bioorg Med Chem Lett,CHEMBL3099950,0.4,Yes,6.397940009
CHEMBL3102091,Inhibition of human ERG expressed in HEK cells after 3 hrs by ion flux electrophysiology,NC(=O)Nc1ccccc1OC[C@@H](O)CN1CCC2(CC1)Cc1cc(Cl)ccc1O2,Bioorg Med Chem Lett,CHEMBL3099949,0.4,Yes,6.397940009
CHEMBL3102091,Inhibition of human ERG expressed in HEK cells after 3 hrs by ion flux electrophysiology,COc1ccc(NC(=O)NC2CC2)c(OC[C@@H](O)CN2CCC3(CC2)Cc2cc(Cl)ccc2O3)c1,Bioorg Med Chem Lett,CHEMBL3099944,0.7,Yes,6.15490196
CHEMBL3102091,Inhibition of human ERG expressed in HEK cells after 3 hrs by ion flux electrophysiology,O=c1ccc2cccc(OC[C@@H](O)CN3CCC4(CC3)Cc3cc(Cl)ccc3O4)c2[nH]1,Bioorg Med Chem Lett,CHEMBL3099953,0.6,Yes,6.22184875
CHEMBL3102091,Inhibition of human ERG expressed in HEK cells after 3 hrs by ion flux electrophysiology,O=C1CCc2cccc(OC[C@@H](O)CN3CCC4(CC3)Cc3cc(Cl)ccc3O4)c2N1,Bioorg Med Chem Lett,CHEMBL3099952,0.5,Yes,6.301029996
CHEMBL3102091,Inhibition of human ERG expressed in HEK cells after 3 hrs by ion flux electrophysiology,O=C1COc2cccc(OC[C@@H](O)CN3CCC4(CC3)Cc3cc(Cl)ccc3O4)c2N1,Bioorg Med Chem Lett,CHEMBL3099951,0.6,Yes,6.22184875
CHEMBL3118368,Inhibition of human ERG by dofetilide binding assay,NC[C@]1(c2cccc(Cl)c2)CC[C@H](N2CCc3c(nc(C(F)(F)F)nc3C3CC3)C2=O)CC1,Bioorg Med Chem Lett,CHEMBL3112968,0.26,Yes,6.585026652
CHEMBL3118391,Binding affinity to human ERG,COC1COCCC1N[C@@H]1C[C@H]2CN(C(=O)C#CC3CC3)C[C@@]2(C(=O)N2CCc3ncc(C(F)(F)F)cc3C2)C1,Bioorg Med Chem Lett,CHEMBL3115274,49.6,No,4.304518324
CHEMBL3118391,Binding affinity to human ERG,COC1COCCC1N[C@@H]1C[C@H]2CN(C3CC3)C[C@@]2(C(=O)N2CCc3ncc(C(F)(F)F)cc3C2)C1,Bioorg Med Chem Lett,CHEMBL3115116,42.1,No,4.375717904
CHEMBL3118391,Binding affinity to human ERG,CCN1C[C@@H]2C[C@@H](NC3CCOCC3OC)C[C@]2(C(=O)N2CCc3ncc(C(F)(F)F)cc3C2)C1,Bioorg Med Chem Lett,CHEMBL3115114,42.6,No,4.370590401
CHEMBL3117583,Inhibition of human ERG by whole-cell patch clamp method,COC(=O)C(CCCN1CCC(c2ccccc2OC)CC1)(c1ccc(Br)cc1)C(C)C,Bioorg Med Chem Lett,CHEMBL3115346,0.78,Yes,6.107905397
CHEMBL3117583,Inhibition of human ERG by whole-cell patch clamp method,COC(=O)C(CCCN(C)CCCc1nc2ccccc2[nH]1)(c1ccc(Br)cc1)C(C)C,Bioorg Med Chem Lett,CHEMBL468397,0.178,Yes,6.749579998
CHEMBL3123230,Inhibition of human ERG expressed in CHO cells,Fc1ccccc1-c1nc2ccn(Cc3cc(-c4ccc(C(F)(F)F)cc4C(F)(F)F)no3)cc-2n1,J Med Chem,CHEMBL3121667,0.79433,Yes,6.099999035
CHEMBL3123230,Inhibition of human ERG expressed in CHO cells,Fc1ccccc1-c1nc2ccn(Cc3ccc(-c4ccc(C(F)(F)F)cc4C(F)(F)F)nn3)cc-2n1,J Med Chem,CHEMBL1957287,0.79433,Yes,6.099999035
CHEMBL3130759,Inhibition of human ERG expressed in CHO-ZG cells after 20 mins by FluxOR thallium assay,N#C[C@@H]1C[C@H](F)CN1C(=O)[C@@H](N)Cc1cscn1,Eur J Med Chem,CHEMBL3127986,176.6,No,3.753009301
CHEMBL3130759,Inhibition of human ERG expressed in CHO-ZG cells after 20 mins by FluxOR thallium assay,N#C[C@@H]1C[C@H](F)CN1C(=O)[C@@H](N)Cc1cc2c(cc1Br)OCO2,Eur J Med Chem,CHEMBL3127992,48,No,4.318758763
CHEMBL3224193,Inhibition of human ERG,C[C@@H](CO)Oc1cc(Oc2ccc(C(=O)N3CCC3)cc2)cc(C(=O)Nc2ccn(C)n2)c1,Medchemcomm,CHEMBL3217925,70,No,4.15490196
CHEMBL3226599,Displacement of [3H]dofetilide from human ERG expressed in CHO cells after 30 mins by FluxOR thallium assay,O=C(/C=C/[C@@H]1CCCN1)N1CCN(c2cnc3cc(C(F)(F)F)cc(NCc4cccc([N+](=O)[O-])c4)c3c2)CC1,Medchemcomm,CHEMBL3220881,86.2,No,4.064492734
CHEMBL3226599,Displacement of [3H]dofetilide from human ERG expressed in CHO cells after 30 mins by FluxOR thallium assay,CN(C)C/C=C/C(=O)N1CCN(c2cnc3cc(C(F)(F)F)cc(NCc4cccc([N+](=O)[O-])c4)c3c2)CC1,Medchemcomm,CHEMBL3220882,92.1,No,4.03574037
CHEMBL3226599,Displacement of [3H]dofetilide from human ERG expressed in CHO cells after 30 mins by FluxOR thallium assay,CCNC(=O)N1CCN(c2cnc3cc(C(F)(F)F)cc(NCc4cccc([N+](=O)[O-])c4)c3c2)CC1,Medchemcomm,CHEMBL3221107,0.21,Yes,6.677780705
CHEMBL3226599,Displacement of [3H]dofetilide from human ERG expressed in CHO cells after 30 mins by FluxOR thallium assay,O=C(N1CCOCC1)N1CCN(c2cnc3cc(C(F)(F)F)cc(NCc4cccc([N+](=O)[O-])c4)c3c2)CC1,Medchemcomm,CHEMBL3221109,0.39,Yes,6.408935393
CHEMBL3226599,Displacement of [3H]dofetilide from human ERG expressed in CHO cells after 30 mins by FluxOR thallium assay,CN1CCN(c2cnc3cc(C(F)(F)F)cc(NCc4cccc([N+](=O)[O-])c4)c3c2)CC1,Medchemcomm,CHEMBL1766528,0.049,Yes,7.30980392
CHEMBL3226599,Displacement of [3H]dofetilide from human ERG expressed in CHO cells after 30 mins by FluxOR thallium assay,CC(=O)N1CCN(c2cnc3cc(C(F)(F)F)cc(NCc4cccc([N+](=O)[O-])c4)c3c2)CC1,Medchemcomm,CHEMBL1766529,0.46,Yes,6.337242168
CHEMBL3226599,Displacement of [3H]dofetilide from human ERG expressed in CHO cells after 30 mins by FluxOR thallium assay,O=[N+]([O-])c1cccc(CNc2cc(C(F)(F)F)cc3ncc(N4CCN(CCO)CC4)cc23)c1,Medchemcomm,CHEMBL3221110,0.037,Yes,7.431798276
CHEMBL3226599,Displacement of [3H]dofetilide from human ERG expressed in CHO cells after 30 mins by FluxOR thallium assay,CN1CCN(c2cnc3cc(C(F)(F)F)cc(NCc4cccc(C#N)c4)c3c2)CC1,Medchemcomm,CHEMBL3221111,0.174,Yes,6.759450752
CHEMBL3226599,Displacement of [3H]dofetilide from human ERG expressed in CHO cells after 30 mins by FluxOR thallium assay,CC(=O)c1cccc(CNc2cc(C(F)(F)F)cc3ncc(N4CCN(C)CC4)cc23)c1,Medchemcomm,CHEMBL3221113,93.6,No,4.028724151
CHEMBL3226599,Displacement of [3H]dofetilide from human ERG expressed in CHO cells after 30 mins by FluxOR thallium assay,CCNC(=O)Nc1cccc(CNc2cc(C(F)(F)F)cc3ncc(N4CCN(C)CC4)cc23)c1,Medchemcomm,CHEMBL3221123,81.7,No,4.087777943
CHEMBL3226599,Displacement of [3H]dofetilide from human ERG expressed in CHO cells after 30 mins by FluxOR thallium assay,CN1CCN(c2cnc3cc(C(F)(F)F)cc(NCc4cccc5nonc45)c3c2)CC1,Medchemcomm,CHEMBL3221125,0.107,Yes,6.970616222
CHEMBL3226599,Displacement of [3H]dofetilide from human ERG expressed in CHO cells after 30 mins by FluxOR thallium assay,CN1CCN(c2cnc3cc(C(F)(F)F)cc(NCc4ccc5cccnc5c4)c3c2)CC1,Medchemcomm,CHEMBL3221126,75.8,No,4.120330794
CHEMBL3226599,Displacement of [3H]dofetilide from human ERG expressed in CHO cells after 30 mins by FluxOR thallium assay,[2H]C([2H])(O)CN1CCN(c2cnc3cc(C(F)(F)F)cc(NCc4cccc([N+](=O)[O-])c4)c3c2)CC1,Medchemcomm,CHEMBL3221133,0.16,Yes,6.795880017
CHEMBL3226599,Displacement of [3H]dofetilide from human ERG expressed in CHO cells after 30 mins by FluxOR thallium assay,[2H]C(Nc1cc(C(F)(F)F)cc2ncc(N3CCN(CC([2H])([2H])O)CC3)cc12)c1cccc([N+](=O)[O-])c1,Medchemcomm,CHEMBL3221134,0.48,Yes,6.318758763
CHEMBL3223680,Inhibition of human ERG,C[C@@H](CO)Oc1cc(Oc2ccc(C(=O)N3CCC3)cc2)cc(C(=O)Nc2ccn(C)n2)c1,Medchemcomm,CHEMBL3217925,70,No,4.15490196
CHEMBL3223680,Inhibition of human ERG,CCn1ccc(NC(=O)c2cc(Oc3ccc(C(=O)N4CCC4)cc3)cc(O[C@@H](C)CO)c2)n1,Medchemcomm,CHEMBL3219105,54,No,4.26760624
CHEMBL3223680,Inhibition of human ERG,CC(C)n1ccc(NC(=O)c2cc(Oc3ccc(C(=O)N4CCC4)cc3)cc(O[C@@H](C)CO)c2)n1,Medchemcomm,CHEMBL3219106,31,No,4.508638306
CHEMBL3223680,Inhibition of human ERG,Cc1cnc(NC(=O)c2cc(Oc3ccc(C(=O)N4CCC4)cc3)cc(O[C@@H](C)CO)c2)cn1,Medchemcomm,CHEMBL3219110,38,No,4.420216403
CHEMBL3223680,Inhibition of human ERG,COC[C@H](C)Oc1cc(Oc2ccc(C(=O)N3CCC3)cc2)cc(C(=O)Nc2ccn(C)n2)c1,Medchemcomm,CHEMBL3219115,36,No,4.443697499
CHEMBL3223680,Inhibition of human ERG,Cn1ccc(NC(=O)c2cc(Oc3ccc(C(=O)N4CCC4)cc3)cc(O[C@H]3CCOC3)c2)n1,Medchemcomm,CHEMBL3219117,35,No,4.455931956
CHEMBL3223680,Inhibition of human ERG,COC[C@H](C)Oc1cc(Oc2ccc(C(=O)N3CCC3)nc2)cc(C(=O)Nc2cnc(C)cn2)c1,Medchemcomm,CHEMBL3219121,40,No,4.397940009
CHEMBL3223962,Inhibition of dofetilide binding to human ERG,Cc1cnc(NC(=O)c2cc(Oc3ccc(C(=O)N(C)C)cc3)c3cc(C)oc3c2)cn1,Medchemcomm,CHEMBL3218482,59,No,4.229147988
CHEMBL3225969,Inhibition of human ERG by [3H]dofetilide binding assay,CC[C@]1(c2cccc(NS(C)(=O)=O)c2)[C@@H]2CN(CC3Cc4ccccc4C3)C[C@@H]21,Medchemcomm,CHEMBL1957718,0.326,Yes,6.4867824
CHEMBL3225969,Inhibition of human ERG by [3H]dofetilide binding assay,CC[C@]1(c2cccc(NS(C)(=O)=O)c2)[C@@H]2CN(CCCC3(O)CCCCC3)C[C@@H]21,Medchemcomm,CHEMBL3219614,0.71,Yes,6.148741651
CHEMBL3224857,Inhibition of human ERG channel expressed in CHO cells by IonWorks assay,N#Cc1ccc2cc1Oc1ccc3cccc(c3c1)N1CC[C@@H](NCCc3cncn3C2)C1=O,Medchemcomm,CHEMBL498260,0.21,Yes,6.677780705
CHEMBL3227234,Inhibition of human ERG,COc1cccc(-n2cc3nc(-c4cccnc4C)n(C[C@H]4CCCN(C(C)C)C4)c(=O)c3n2)c1,Medchemcomm,CHEMBL3218890,47,No,4.327902142
CHEMBL3227234,Inhibition of human ERG,COCCN1CCC[C@H](Cn2c(-c3cccnc3C)nc3cn(-c4cccc(OC)c4)nc3c2=O)C1,Medchemcomm,CHEMBL3218891,43,No,4.366531544
CHEMBL3227234,Inhibition of human ERG,COc1cccc(-n2cc3nc(-c4cccnc4C)n(C[C@H]4CCCN(C[C@H]5CCCO5)C4)c(=O)c3n2)c1,Medchemcomm,CHEMBL3218897,44,No,4.356547324
CHEMBL3226991,Inhibition of human ERG,COCC[C@H](Oc1ncnc2c1cnn2-c1ncccc1Cl)C(=O)Nc1ccc(C)cn1,Medchemcomm,CHEMBL3221481,79.43282,No,4.100000019
CHEMBL3226991,Inhibition of human ERG,CC(C)OC[C@H](Oc1ncnc2c1cnn2-c1ncccc1Cl)C(=O)Nc1ccc(F)cn1,Medchemcomm,CHEMBL3221496,79.43282,No,4.100000019
CHEMBL3226991,Inhibition of human ERG,CCOC[C@H](Oc1ncnc2c1cnn2-c1ncccc1Cl)C(=O)Nc1ccc(C)cn1,Medchemcomm,CHEMBL3221485,63.09573,No,4.200000031
CHEMBL3226991,Inhibition of human ERG,CC(C)OC[C@H](Oc1ncnc2c1cnn2-c1ncccc1Cl)C(=O)Nc1ccc(Cl)cn1,Medchemcomm,CHEMBL3221493,63.09573,No,4.200000031
CHEMBL3226991,Inhibition of human ERG,CCOC[C@H](Oc1ncnc2c1cnn2-c1ncccc1Cl)C(=O)Nc1ccc(F)cn1,Medchemcomm,CHEMBL3221498,63.09573,No,4.200000031
CHEMBL3226991,Inhibition of human ERG,CC(C)OC[C@H](Oc1ncnc2c1cnn2-c1ccccc1Cl)C(=O)Nc1ccccn1,Medchemcomm,CHEMBL3221500,63.09573,No,4.200000031
CHEMBL3226991,Inhibition of human ERG,COC[C@H](Oc1ncnc2c1cnn2-c1ccccc1Cl)C(=O)Nc1ccc(C)cn1,Medchemcomm,CHEMBL3221482,50.11872,No,4.300000029
CHEMBL3226991,Inhibition of human ERG,CCOC[C@H](Oc1ncnc2c1cnn2-c1ccccc1Cl)C(=O)Nc1cnc(C)cn1,Medchemcomm,CHEMBL3221486,50.11872,No,4.300000029
CHEMBL3226991,Inhibition of human ERG,CC(C)OC[C@H](Oc1ncnc2c1cnn2-c1ncccc1Cl)C(=O)Nc1ccc(C#N)cn1,Medchemcomm,CHEMBL3221502,50.11872,No,4.300000029
CHEMBL3226991,Inhibition of human ERG,Cc1ccc(NC(=O)[C@H](COC2CCC2)Oc2ncnc3c2cnn3-c2ncccc2Cl)nc1,Medchemcomm,CHEMBL3221490,39.81072,No,4.399999968
CHEMBL3226991,Inhibition of human ERG,Cc1cnc(NC(=O)[C@H](COC2CCC2)Oc2ncnc3c2cnn3-c2ncccc2Cl)cn1,Medchemcomm,CHEMBL3221492,39.81072,No,4.399999968
CHEMBL3226991,Inhibition of human ERG,Cc1ccc(NC(=O)[C@H](COC(C)C)Oc2ncnc3c2cnn3-c2ccccc2Cl)nc1,Medchemcomm,CHEMBL3221488,31.62278,No,4.499999953
CHEMBL3227002,Inhibition of human ERG by electrophysiological analysis,CC(C)OC[C@H](Oc1ncnc2c1cnn2-c1ncccc1Cl)C(=O)Nc1ccc(Cl)cn1,Medchemcomm,CHEMBL3221493,63.09573,No,4.200000031
CHEMBL3227002,Inhibition of human ERG by electrophysiological analysis,CC(C)OC[C@H](Oc1ncnc2c1cnn2-c1ncccc1Cl)C(=O)Nc1ccc(F)cn1,Medchemcomm,CHEMBL3221496,79.43282,No,4.100000019
CHEMBL3227002,Inhibition of human ERG by electrophysiological analysis,CC(C)OC[C@H](Oc1ncnc2c1cnn2-c1ncccc1Cl)C(=O)Nc1ccc(C#N)cn1,Medchemcomm,CHEMBL3221502,50.11872,No,4.300000029
CHEMBL3227002,Inhibition of human ERG by electrophysiological analysis,O=C(Nc1ccc(Cl)cn1)[C@H](COCCO)Oc1ncnc2c1cnn2-c1ncccc1Cl,Medchemcomm,CHEMBL3221506,50.11872,No,4.300000029
CHEMBL3227002,Inhibition of human ERG by electrophysiological analysis,N#Cc1ccc(NC(=O)[C@H](COCCO)Oc2ncnc3c2cnn3-c2ncccc2Cl)nc1,Medchemcomm,CHEMBL3221507,50.11872,No,4.300000029
CHEMBL3227002,Inhibition of human ERG by electrophysiological analysis,C[C@@H](CO)OC[C@H](Oc1ncnc2c1cnn2-c1ncccc1Cl)C(=O)Nc1ccc(C#N)cn1,Medchemcomm,CHEMBL3221511,63.09573,No,4.200000031
CHEMBL3227002,Inhibition of human ERG by electrophysiological analysis,C[C@H](CO)OC[C@H](Oc1ncnc2c1cnn2-c1ncccc1Cl)C(=O)Nc1ccc(C#N)cn1,Medchemcomm,CHEMBL3221514,63.09573,No,4.200000031
CHEMBL3227002,Inhibition of human ERG by electrophysiological analysis,O=C(Nc1ccc(Cl)cn1)[C@H](CN1CC(O)C1)Oc1ncnc2c1cnn2-c1ncccc1Cl,Medchemcomm,CHEMBL3221515,50.11872,No,4.300000029
CHEMBL3227002,Inhibition of human ERG by electrophysiological analysis,O=C(Nc1ccc(F)cn1)[C@H](CN1CC(O)C1)Oc1ncnc2c1cnn2-c1ccccc1Cl,Medchemcomm,CHEMBL3221520,39.81072,No,4.399999968
CHEMBL3227002,Inhibition of human ERG by electrophysiological analysis,O=C(Nc1ccc(F)cn1)[C@H](CN1CC(O)C1)Oc1ncnc2c1cnn2-c1ccccc1Cl,Medchemcomm,CHEMBL3221520,36,No,4.443697499
CHEMBL3227002,Inhibition of human ERG by electrophysiological analysis,O=C(Nc1ccc(F)cn1)[C@H](COCCO)Oc1ncnc2c1cnn2-c1ccccc1Cl,Medchemcomm,CHEMBL3221521,39.81072,No,4.399999968
CHEMBL3227002,Inhibition of human ERG by electrophysiological analysis,N#Cc1cccc(Cl)c1-n1ncc2c(O[C@@H](CN3CC(O)C3)C(=O)Nc3ccc(F)cn3)ncnc21,Medchemcomm,CHEMBL3221526,50.11872,No,4.300000029
CHEMBL3227002,Inhibition of human ERG by electrophysiological analysis,N#Cc1cccc(Cl)c1-n1ncc2c(O[C@@H](COCCO)C(=O)Nc3ccc(F)cn3)ncnc21,Medchemcomm,CHEMBL3221527,63.09573,No,4.200000031
CHEMBL3227002,Inhibition of human ERG by electrophysiological analysis,O=C(Nc1ccccn1)[C@H](CN1CC(O)C1)Oc1ncnc2c1cnn2-c1c(F)cccc1Cl,Medchemcomm,CHEMBL3221528,79.43282,No,4.100000019
CHEMBL3227002,Inhibition of human ERG by electrophysiological analysis,O=C(Nc1ccc(F)cn1)[C@H](COCCO)Oc1ncnc2c1cnn2-c1c(F)cccc1Cl,Medchemcomm,CHEMBL3221530,31.62278,No,4.499999953
CHEMBL3227002,Inhibition of human ERG by electrophysiological analysis,Cc1cnc(NC(=O)[C@H](CN2CC(O)C2)Oc2ncnc3c2cnn3-c2c(Cl)cccc2Cl)cn1,Medchemcomm,CHEMBL3221531,62,No,4.207608311
CHEMBL3239511,Inhibition of human ERG,NC(=O)c1cc(-c2ccccc2F)sc1Nc1cccc(CN2CCOCC2)n1,Bioorg Med Chem Lett,CHEMBL3234874,0.161,Yes,6.793174124
CHEMBL3243551,Inhibition of human ERG by FLIPR assay,CCS(=O)(=O)C[C@@H]1C[C@H](N(C)C(C)C)CC[C@@H]1N1CC[C@H](NC(=O)c2cccc(-c3ccccc3)c2)C1=O,Bioorg Med Chem Lett,CHEMBL3233185,60,No,4.22184875
CHEMBL3243551,Inhibition of human ERG by FLIPR assay,CC(C)N(C)[C@@H]1CC[C@H](N2CC[C@H](NC(=O)c3cccc(C(C)(C)C)c3)C2=O)[C@H](CS(=O)(=O)C(C)C)C1,Bioorg Med Chem Lett,CHEMBL3233187,77,No,4.113509275
CHEMBL3240534,Binding affinity to human ERG,Fc1nccc2c3cnc(Nc4ccc(N5CCNCC5)cn4)nc3n(C3CCCC3)c12,J Med Chem,CHEMBL3237443,0.72,Yes,6.142667504
CHEMBL3240534,Binding affinity to human ERG,C[C@@H](O)CN(C)C1CCN(c2ccc(Nc3ncc4c5ccncc5n([C@H]5CC[C@H](C)CC5)c4n3)nn2)CC1,J Med Chem,CHEMBL3237713,0.92,Yes,6.036212173
CHEMBL3268528,Displacement of [3H]-astemizole from human ERG expressed in HEK293 cells,O=C(N1CCc2ncc(C(F)(F)F)cc2C1)[C@@]12CCO[C@@H]1C[C@@H](NC1CCOCC1)C2,Bioorg Med Chem Lett,CHEMBL3263279,43,No,4.366531544
CHEMBL3266651,Inhibition of human ERG expressed in CHO cells by whole-cell patch clamp assay,C[C@@H](n1cnc2cc(Cl)ccc2c1=O)[C@](O)(Cn1cncn1)c1ccc(F)cc1F,J Med Chem,CHEMBL298817,34.86,No,4.457672617
CHEMBL3266651,Inhibition of human ERG expressed in CHO cells by whole-cell patch clamp assay,COc1cc(N)c(Cl)cc1C(=O)NC1CCN(CCCOc2ccc(F)cc2)CC1OC,J Med Chem,CHEMBL1729,0.08,Yes,7.096910013
CHEMBL3271188,Inhibition of human ERG channel expressed in HEK293 cells after 3 to 5.7 mins by whole-cell patch clamp technique,Cc1cccc(-c2[nH]c(CNc3ccccc3F)nc2-c2ccc3ncnn3c2)n1,J Med Chem,CHEMBL3260567,31.04,No,4.508078287
CHEMBL3268691,Inhibition of human ERG by whole-cell voltage clamp assay,Cl.c1cncc(OC[C@H]2CNCCN2c2nc3ncccc3o2)c1,J Med Chem,CHEMBL3262132,72,No,4.142667504
CHEMBL3268691,Inhibition of human ERG by whole-cell voltage clamp assay,COc1ccc(NC(=O)N2CCNC[C@@H]2COc2cccnc2)cc1.Cl,J Med Chem,CHEMBL3262163,31,No,4.508638306
CHEMBL3296755,Inhibition of human ERG,CCN(CC)CCNC(=O)c1c(C)[nH]c(/C=C2\C(=O)Nc3ccc(F)cc32)c1C,Eur J Med Chem,CHEMBL535,0.5,Yes,6.301029996
CHEMBL3296720,Inhibition of human ERG,Nc1nccn1CC(O)c1ccc(Cl)cc1F,J Med Chem,CHEMBL3289792,60,No,4.22184875
CHEMBL3294274,Inhibition of human ERG,CC1CN(CC(=O)N[C@H]2C3CC4CC2C[C@](C(N)=O)(C4)C3)S(=O)(=O)N(c2c(Cl)cc(Cl)cc2Cl)C1,J Med Chem,CHEMBL2036234,37,No,4.431798276
CHEMBL3295404,Inhibition of human cloned ERG expressed in CHO cells assessed as inhibition of potassium channel current by automated patch clamp assay,Cc1cccc(CCN2CCC(C(=O)c3ccc(NS(C)(=O)=O)cc3)CC2)n1.Cl.Cl,J Med Chem,CHEMBL536480,0.089,Yes,7.050609993
CHEMBL3295404,Inhibition of human cloned ERG expressed in CHO cells assessed as inhibition of potassium channel current by automated patch clamp assay,O=C1NCCN1CCN1CCC(c2cn(-c3ccc(F)cc3)c3ccc(Cl)cc23)CC1,J Med Chem,CHEMBL12713,0.0027,Yes,8.568636236
CHEMBL3292514,Inhibition of human ERG,Cc1cc(C(=O)N[C@H]2CC[C@@H](NC(=O)c3cc(F)cnc3Oc3cccc(-c4ccc(O)cc4CN4CCOCC4)c3)CC2)nn1C,J Med Chem,CHEMBL3287739,31.62278,No,4.499999953
CHEMBL3292600,Inhibition of human ERG tail current by patch clamp method,Cc1cccc(CCN2CCC(C(=O)c3ccc(NS(C)(=O)=O)cc3)CC2)n1.Cl.Cl,J Med Chem,CHEMBL536480,0.024,Yes,7.619788758
CHEMBL3294033,Inhibition of human ERG by patch clamp electrophysiological analysis,N#Cc1ccc2ccc(=O)n(CCN3CCC(NCc4cc5c(cn4)OCCO5)CC3)c2c1,J Med Chem,CHEMBL2165062,44,No,4.356547324
CHEMBL3294033,Inhibition of human ERG by patch clamp electrophysiological analysis,Cc1ncc(CNC2CCN(CCn3c(=O)ccc4ncc(F)cc43)CC2)cc1C#N,J Med Chem,CHEMBL3290340,69,No,4.161150909
CHEMBL3294033,Inhibition of human ERG by patch clamp electrophysiological analysis,COc1cnc2ccc(=O)n(CCN3CCC(NCc4cnc(C)c(C#N)c4)CC3)c2c1,J Med Chem,CHEMBL3290341,50.6,No,4.295849483
CHEMBL3294033,Inhibition of human ERG by patch clamp electrophysiological analysis,Cc1ncc(CNC2CCN(CCn3c(=O)ccc4c3ccc(=O)n4C)CC2)cc1C#N,J Med Chem,CHEMBL3290343,33,No,4.48148606
CHEMBL3294033,Inhibition of human ERG by patch clamp electrophysiological analysis,COc1cnc2ccc(=O)n(CCN3CCC(NC(=O)c4cnc(C)c(C#N)c4)CC3)c2c1,J Med Chem,CHEMBL3290344,74,No,4.13076828
CHEMBL3294033,Inhibition of human ERG by patch clamp electrophysiological analysis,COc1cnc2ccc(=O)n(CCN3CCC(NCc4cnc(C)c(C#N)n4)CC3)c2c1,J Med Chem,CHEMBL3290346,69,No,4.161150909
CHEMBL3294033,Inhibition of human ERG by patch clamp electrophysiological analysis,Cc1ncc(CN[C@@H]2CCN(CCn3c(=O)ccc4ncc(F)cc43)C[C@@H]2F)cc1C#N,J Med Chem,CHEMBL3290350,133,No,3.876148359
CHEMBL3294033,Inhibition of human ERG by patch clamp electrophysiological analysis,COc1cnc2ccc(=O)n(CCN3CC[C@@H](NCc4cnc(C)c(C#N)c4)[C@@H](F)C3)c2c1,J Med Chem,CHEMBL3290351,90,No,4.045757491
CHEMBL3294033,Inhibition of human ERG by patch clamp electrophysiological analysis,COc1cnc2ccc(=O)n(CCN3CC[C@@H](NCc4cnc(C)c(C#N)c4)[C@@H](OC)C3)c2c1,J Med Chem,CHEMBL3290352,151,No,3.821023053
CHEMBL3295909,Inhibition of human ERG expressed in CHO cells by automated patch clamp assay,COc1ccc2ncc(F)c(CCC34CCC(NCc5ccc6c(n5)NC(=O)CO6)(CC3)CO4)c2n1.Cl,ACS Med Chem Lett,CHEMBL3288810,0.6,Yes,6.22184875
CHEMBL3381617,Inhibition of human ERG expressed in CHO cells by Rb efflux assay,O=C(CNCCc1c(Cl)cccc1Cl)N1CCc2ccccc2C1C1CCCCC1,Bioorg Med Chem,CHEMBL3356242,54.7,No,4.262012674
CHEMBL3381617,Inhibition of human ERG expressed in CHO cells by Rb efflux assay,O=C(CNCC1(O)CCCCC1)N1CCc2ccccc2C1C1CCCCC1,Bioorg Med Chem,CHEMBL3356247,46.1,No,4.336299075
CHEMBL3381617,Inhibition of human ERG expressed in CHO cells by Rb efflux assay,O=C(CNCC1(O)CCCC1)N1CCc2ccccc2C1C1CCCCC1,Bioorg Med Chem,CHEMBL3356248,78.6,No,4.104577454
CHEMBL3381617,Inhibition of human ERG expressed in CHO cells by Rb efflux assay,O=C(CNCC1(O)CCCCCC1)N1CCc2ccccc2C1C1CCCCC1,Bioorg Med Chem,CHEMBL3356249,50.1,No,4.300162274
CHEMBL3381617,Inhibition of human ERG expressed in CHO cells by Rb efflux assay,O=C(CNCC1(O)CCCCC1)N1CCc2ccccc2[C@@H]1C1CCCCC1,Bioorg Med Chem,CHEMBL3356251,98,No,4.008773924
CHEMBL3381617,Inhibition of human ERG expressed in CHO cells by Rb efflux assay,O=C(CNCC1(O)CCCCC1)N1CCc2ccccc2[C@H]1C1CCCCC1,Bioorg Med Chem,CHEMBL3356252,76,No,4.119186408
CHEMBL3378079,Inhibition of human ERG over-expressed in HEK293 cell membrane by [3H]dofetilide binding assay,CN(C)c1ccc(/C=C/c2c(F)cccc2F)cc1,J Med Chem,CHEMBL2153098,32.1,No,4.493494968
CHEMBL3378079,Inhibition of human ERG over-expressed in HEK293 cell membrane by [3H]dofetilide binding assay,CNc1ccc(/C=C/c2c(F)cccc2F)cc1,J Med Chem,CHEMBL3314417,49.1,No,4.308918508
CHEMBL3378079,Inhibition of human ERG over-expressed in HEK293 cell membrane by [3H]dofetilide binding assay,CNc1ccc(/C=C/c2c(F)cccc2Cl)cc1,J Med Chem,CHEMBL3314420,49.8,No,4.302770657
CHEMBL3378079,Inhibition of human ERG over-expressed in HEK293 cell membrane by [3H]dofetilide binding assay,CN(C)c1ccc(/C=C/c2c(F)cccc2Cl)cn1,J Med Chem,CHEMBL3314429,59.5,No,4.225483034
CHEMBL3378079,Inhibition of human ERG over-expressed in HEK293 cell membrane by [3H]dofetilide binding assay,CN(C)c1ncc(/C=C/c2c(F)cccc2F)cn1,J Med Chem,CHEMBL3314433,40.5,No,4.392544977
CHEMBL3378637,Inhibition of human ERG by MK-499 displacement binding analysis,CCOC(=O)c1cccc([C@@]2(c3cnn(C)c3)N[C@@H](c3nc(-c4ccc(F)cc4)c[nH]3)Cc3c2[nH]c2ccccc32)n1,ACS Med Chem Lett,CHEMBL3323073,0.625,Yes,6.204119983
CHEMBL3378637,Inhibition of human ERG by MK-499 displacement binding analysis,CCOC(=O)c1cccc([C@]2(c3cnn(C)c3)N[C@@H](c3nc(-c4ccc(F)cc4)c[nH]3)Cc3c2[nH]c2ccccc32)n1,ACS Med Chem Lett,CHEMBL3323072,0.707,Yes,6.150580586
CHEMBL3380409,Inhibition of human ERG channel,CCNC(=O)N1CC2(CCN(CC3CCN(C(=O)OCC)CC3)CC2)c2cccnc21,Bioorg Med Chem Lett,CHEMBL3310798,0.23,Yes,6.638272164
CHEMBL3380409,Inhibition of human ERG channel,CCOC(=O)N1CCC(CN2CCC3(CC2)CN(C(=O)NC)c2ncccc23)CC1,Bioorg Med Chem Lett,CHEMBL3310800,0.3,Yes,6.522878745
CHEMBL3380409,Inhibition of human ERG channel,CCOC(=O)N1CCC(CN2CCC3(CC2)CN(C(N)=O)c2ncccc23)CC1,Bioorg Med Chem Lett,CHEMBL3310801,0.19,Yes,6.721246399
CHEMBL3369560,Inhibition of human ERG,O=c1ccc2ncc(=O)n3c2n1C[C@H]3CN1CCC(NCc2cc3c(cn2)OCCC3)CC1,Bioorg Med Chem Lett,CHEMBL3317856,1400,No,2.853871964
CHEMBL3372547,Inhibition of human ERG channel,O=C1NC(=O)C(Cc2coc3ccc(Cl)cc3c2=O)S1,Bioorg Med Chem Lett,CHEMBL3299132,0.135,Yes,6.869666232
CHEMBL3368358,Inhibition of human ERG expressed in CHO cells by electrophysiology assay,CN(C)Cc1ccc2c(c1)CCN(C(=O)c1cc3cc(Br)ncc3n1C)C2,J Med Chem,CHEMBL3314352,31.2,No,4.505845406
CHEMBL3361754,Inhibition of human ERG by cell-based patch clamp method,COc1ccc2ncc(=O)n(CCN3CCC(NCc4ccc5c(n4)NC(=O)CO5)CC3)c2c1,Bioorg Med Chem,CHEMBL2165063,35,No,4.455931956
CHEMBL3361754,Inhibition of human ERG by cell-based patch clamp method,N[C@@H](Cn1c(=O)cnc2ccc(F)cc21)[C@H]1CC[C@H](NCc2ccc3c(n2)NC(=O)CO3)CC1,Bioorg Med Chem,CHEMBL3355572,174,No,3.759450752
CHEMBL3384134,Inhibition of human ERG by patch clamp assay,O=C(NC[C@@H]1OC(=O)N2c3ccc(N4CCOCC4=O)cc3OC[C@@H]12)c1ccc(Cl)s1,J Med Chem,CHEMBL3330442,79.75,No,4.098269308
CHEMBL3361668,Inhibition of human ERG expressed in CHO-K1 cells by whole cell patch-clamp assay,C#CCNc1ccnc2sc3c(=O)n(-c4ccc(OC)cc4)cnc3c12,Eur J Med Chem,CHEMBL1783876,31,No,4.508638306
CHEMBL3390017,Displacement of [3H]astemizole from human ERG expressed in HEK293 cells by scintillation counting method,CC(C)(C)c1ccc(C(O)CCCN2CCC(C(O)(c3ccccc3)c3ccccc3)CC2)cc1,J Med Chem,CHEMBL17157,0.13,Yes,6.886056648
CHEMBL3390017,Displacement of [3H]astemizole from human ERG expressed in HEK293 cells by scintillation counting method,OC(c1ccccc1)(c1ccccc1)C1CCN(Cc2ccc(-c3ccccc3)cc2)CC1,J Med Chem,CHEMBL3343216,0.21,Yes,6.677780705
CHEMBL3390017,Displacement of [3H]astemizole from human ERG expressed in HEK293 cells by scintillation counting method,OC(c1ccccc1)(c1ccccc1)C1CCN(CCCOc2ccc(-c3ccccc3)cc2)CC1,J Med Chem,CHEMBL3344385,0.14,Yes,6.853871964
CHEMBL3370430,Inhibition of human ERG expressed in CHO cells after 20 mins by thallium assay,N#C[C@@H]1C[C@H](F)CN1C(=O)C[C@H](N)Cc1cc(F)c(F)cc1F,Eur J Med Chem,CHEMBL3330060,97.7,No,4.010105436
CHEMBL3370430,Inhibition of human ERG expressed in CHO cells after 20 mins by thallium assay,N#C[C@@H]1C[C@@H]2CCC[C@@H]2N1C(=O)C[C@H](N)Cc1cc(F)c(F)cc1F,Eur J Med Chem,CHEMBL3330073,55.3,No,4.257274869
CHEMBL3367333,Inhibition of human ERG expressed in HEK293 cells assessed as reduction in channel tail current by patch clamp method,O=C(OCC1CCN(CC(O)CO)CC1)c1c2n(c3ccccc13)CCCO2,Bioorg Med Chem Lett,CHEMBL3329814,81,No,4.091514981
CHEMBL3367333,Inhibition of human ERG expressed in HEK293 cells assessed as reduction in channel tail current by patch clamp method,O=C(OCC1CCN(CC2CCC(C(=O)O)C2)CC1)c1c2n(c3ccccc13)CCCO2,Bioorg Med Chem Lett,CHEMBL3329811,209,No,3.679853714
CHEMBL3382404,Inhibition of human ERG,O=C1NC(=O)/C(=C\c2ccccc2OCc2nnc(-c3ccccc3)o2)S1,Eur J Med Chem,CHEMBL3338895,41,No,4.387216143
CHEMBL3381295,Inhibition of human ERG channel by patch clamp technique,C[S+]([O-])c1ccc(-c2cnc3ccc(-c4cccc(S(=O)(=O)C5CC5)c4)nn23)cc1,J Med Chem,CHEMBL3355638,0.4,Yes,6.397940009
CHEMBL3381295,Inhibition of human ERG channel by patch clamp technique,CS(=O)(=O)c1ccc(-c2cnc3ccc(-c4cccc(S(=O)(=O)C5CC5)c4)nn23)cc1,J Med Chem,CHEMBL3355639,0.4,Yes,6.397940009
CHEMBL3387701,Inhibition of human ERG,Cc1nn(C)c(C)c1N(C(F)F)S(=O)(=O)c1c(Cl)cc(CCCC2CCN(C)CC2)cc1Cl,J Med Chem,CHEMBL3358114,0.6,Yes,6.22184875
CHEMBL3382984,Inhibition of ERG channel in HEK293 cells by whole cell patch clamp technique,Cc1nc(-c2ccccc2)nc(OCCCN2CCCCC2)c1Cl,J Med Chem,CHEMBL3359220,0.28,Yes,6.552841969
CHEMBL3382984,Inhibition of ERG channel in HEK293 cells by whole cell patch clamp technique,Cc1ccc(-c2nc(C)c(Cl)c(OCCCN3CCCCC3)n2)cc1,J Med Chem,CHEMBL3359234,0.95,Yes,6.022276395
CHEMBL3385491,Inhibition of human ERG channel by patch-clamp assay,Cc1nc2ccc(C(=O)N3CCC4(CC3)CC(=O)c3c(cnn3C(C)C)C4)cc2[nH]1,J Med Chem,CHEMBL3359265,141,No,3.850780887
CHEMBL3385491,Inhibition of human ERG channel by patch-clamp assay,CC(C)(C)n1cc2c(n1)C(=O)CC1(CCN(C(=O)c3ccc4[nH]ncc4c3)CC1)O2,J Med Chem,CHEMBL2419601,34,No,4.468521083
CHEMBL3396429,Inhibition of human ERG,Oc1ccc(-c2ccc3[nH]nc(-c4cncc(O[C@H]5CNCCC56CC6)n4)c3c2)c(F)c1,Bioorg Med Chem Lett,CHEMBL3393717,0.8,Yes,6.096910013
CHEMBL3396351,Inhibition of human ERG by patch clamp assay,COc1ccc(CC(=O)N2CCC3(CC2)CN([C@@H]2CCc4cc(-c5cc(C)ncn5)ccc42)C3)c(C(N)=O)c1,ACS Med Chem Lett,CHEMBL3394201,47,No,4.327902142
CHEMBL3399089,Inhibition of human ERG,CC(C)N1Cc2cc(-c3cc(-c4ccc(Cl)nc4)no3)ccc2C1=O,Bioorg Med Chem Lett,CHEMBL3398278,40,No,4.397940009
CHEMBL3404543,Inhibition of human ERG by MK499 binding assay,O=C1COc2ccc(CNC34CCC(C[C@]5(O)Cn6c(=O)ccc7ncc(Cl)c5c76)(CC3)OC4)nc2N1,Bioorg Med Chem Lett,CHEMBL3402185,53.3,No,4.273272791
CHEMBL3404544,Inhibition of human ERG expressed in CHO cells by Patch express assay,O=C1COc2ccc(CNC34CCC(C[C@]5(O)Cn6c(=O)ccc7ncc(F)c5c76)(CC3)OC4)nc2N1,Bioorg Med Chem Lett,CHEMBL3400817,174,No,3.759450752
CHEMBL3404544,Inhibition of human ERG expressed in CHO cells by Patch express assay,O=C1COc2ccc(CNC34CCC(C[C@@]5(O)Cn6c(=O)ccc7ncc(F)c5c76)(CC3)OC4)nc2N1,Bioorg Med Chem Lett,CHEMBL3400818,394,No,3.404503778
CHEMBL3413549,Inhibition of human ERG expressed in CHO cells assessed as reduction in channel current at holding potential of 0 mV by electrophysiological method,Cc1cccc(CCN2CCC(C(=O)c3ccc(NS(C)(=O)=O)cc3)CC2)n1.Cl.Cl,Eur J Med Chem,CHEMBL536480,0.089,Yes,7.050609993
CHEMBL3413736,Inhibition of human ERG assessed as reduction in channel current expressed in HEK cells by patch clamp assay,N#Cc1c(-c2ccccc2)cc(-c2ccccc2)nc1NC(=S)Nc1ccccc1,Eur J Med Chem,CHEMBL3408381,48.4,No,4.315154638
CHEMBL3413736,Inhibition of human ERG assessed as reduction in channel current expressed in HEK cells by patch clamp assay,CC(=O)c1nn(-c2ccccc2)/c(=N/c2nc(-c3ccccc3)cc(-c3ccccc3)c2C#N)s1,Eur J Med Chem,CHEMBL3408383,32.6,No,4.4867824
CHEMBL3413736,Inhibition of human ERG assessed as reduction in channel current expressed in HEK cells by patch clamp assay,N#Cc1c(-c2ccccc2)cc(-c2ccccc2)nc1/N=C1\SCC(=O)N1c1ccccc1,Eur J Med Chem,CHEMBL3408391,45.5,No,4.341988603
CHEMBL3419515,Inhibition of human ERG expressed in CHO cells at -80 mV holding potential by whole cell patch clamp assay,C[C@@H]1CCC[C@H](C)N1CCNc1cn(Cc2ccc(F)cc2)nn1,J Med Chem,CHEMBL3417071,0.6,Yes,6.22184875
CHEMBL3418525,Inhibition of ERG channel expressed in human embryonic kidney cells assessed as tail current amplitude measured for 3 to 30 mins by PatchXpress electrophysiology assay,Cc1cc(Nc2cc(N[C@@H]3CCCC[C@@H]3N)cnc2C(N)=O)nc(-n2nccn2)n1,J Med Chem,CHEMBL3415598,44,No,4.356547324
CHEMBL3418525,Inhibition of ERG channel expressed in human embryonic kidney cells assessed as tail current amplitude measured for 3 to 30 mins by PatchXpress electrophysiology assay,NC(=O)c1ncc(N[C@@H]2CCCC[C@@H]2N)cc1Nc1cccc(C(F)(F)F)n1,J Med Chem,CHEMBL3415592,0.6,Yes,6.22184875
CHEMBL3420425,Displacement of radio-labeled MK-499 from ERG channel in human embryonic kidney cells,Cc1cc(C)nc(Nc2cc(NC[C@@H](N)C(F)(F)F)cnc2C(N)=O)c1,J Med Chem,CHEMBL3415586,42,No,4.37675071
CHEMBL3420397,Inhibition of human ERG channel expressed in CHO cells by patch clamp method,C=CCOc1ccc(Cl)cc1[C@H]1C[C@@H]1CN.O=C(O)C(F)(F)F,J Med Chem,CHEMBL3416047,0.27,Yes,6.568636236
CHEMBL3419072,Inhibition of human ERG channel after 2 hrs by fluorescence polarization assay,COc1ccc(Oc2ccc(S(=O)(=O)C3(C(=O)NO)CCC4(CCNCC4)C3)cc2)cc1,J Med Chem,CHEMBL3417742,37,No,4.431798276
CHEMBL3419072,Inhibition of human ERG channel after 2 hrs by fluorescence polarization assay,O=C(NO)C1(S(=O)(=O)c2ccc(Oc3ccc(OC(F)(F)F)cc3)cc2)CCC2(CCNCC2)C1,J Med Chem,CHEMBL3417745,100,No,4
CHEMBL3419072,Inhibition of human ERG channel after 2 hrs by fluorescence polarization assay,O=C(NO)C1(S(=O)(=O)c2ccc(OCc3ccc(OC(F)(F)F)cc3)cc2)CCC2(CCNCC2)C1,J Med Chem,CHEMBL3417746,50.3,No,4.298432015
CHEMBL3419072,Inhibition of human ERG channel after 2 hrs by fluorescence polarization assay,COc1ccc(C(=O)Oc2ccc(S(=O)(=O)C3(C(=O)NO)CCC4(CCNCC4)C3)cc2)cc1,J Med Chem,CHEMBL3417767,63.4,No,4.197910742
CHEMBL3424851,Inhibition of MK499 binding to human ERG,COc1ccc2ncc(Cl)c(CCC34CCC(NCc5ccc6c(n5)NC(=O)CO6)(CC3)CO4)c2n1,Bioorg Med Chem Lett,CHEMBL3422754,0.32,Yes,6.494850022
CHEMBL3424851,Inhibition of MK499 binding to human ERG,COc1ccc2nccc(CCC34CCC(NCc5ccc6c(n5)NC(=O)CO6)(CC3)CO4)c2n1,Bioorg Med Chem Lett,CHEMBL3422755,0.56,Yes,6.251811973
CHEMBL3424851,Inhibition of MK499 binding to human ERG,COc1ccc2ncc(C#N)c(CCC34CCC(NCc5ccc6c(n5)NC(=O)CO6)(CC3)CO4)c2n1,Bioorg Med Chem Lett,CHEMBL3422756,0.37,Yes,6.431798276
CHEMBL3424851,Inhibition of MK499 binding to human ERG,COc1ccc2ncc(C(F)(F)F)c(CCC34CCC(NCc5ccc6c(n5)NC(=O)CO6)(CC3)CO4)c2n1,Bioorg Med Chem Lett,CHEMBL3422757,0.13,Yes,6.886056648
CHEMBL3424851,Inhibition of MK499 binding to human ERG,O=C1COc2ccc(CNC34CCC(CCc5c(F)cnc6ccc(O)nc56)(CC3)OC4)nc2N1,Bioorg Med Chem Lett,CHEMBL3422765,0.00483,Yes,8.316052869
CHEMBL3424851,Inhibition of MK499 binding to human ERG,COC(=O)c1ccc2ncc(F)c(CCC34CCC(NCc5ccc6c(n5)NC(=O)CO6)(CC3)CO4)c2n1,Bioorg Med Chem Lett,CHEMBL3422768,0.00875,Yes,8.057991947
CHEMBL3424851,Inhibition of MK499 binding to human ERG,N#Cc1ccc2ncc(F)c(CCC34CCC(NCc5ccc6c(n5)NC(=O)CO6)(CC3)CO4)c2n1,Bioorg Med Chem Lett,CHEMBL3422947,0.00387,Yes,8.412289035
CHEMBL3424851,Inhibition of MK499 binding to human ERG,Nc1ccc2ncc(F)c(CCC34CCC(NCc5ccc6c(n5)NC(=O)CO6)(CC3)CO4)c2n1,Bioorg Med Chem Lett,CHEMBL3422948,0.00321,Yes,8.493494968
CHEMBL3424851,Inhibition of MK499 binding to human ERG,CN(C)c1ccc2ncc(F)c(CCC34CCC(NCc5ccc6c(n5)NC(=O)CO6)(CC3)CO4)c2n1,Bioorg Med Chem Lett,CHEMBL3422949,0.00835,Yes,8.078313525
CHEMBL3424851,Inhibition of MK499 binding to human ERG,O=C1COc2ccc(CNC34CCC(CCc5c(F)cnc6ccc(N7CCOCC7)nc56)(CC3)OC4)nc2N1,Bioorg Med Chem Lett,CHEMBL3422950,0.01146,Yes,7.940815382
CHEMBL3424851,Inhibition of MK499 binding to human ERG,COc1cc2ncc(F)c(CCC34CCC(NCc5ccc6c(n5)NC(=O)CO6)(CC3)CO4)c2nc1OC,Bioorg Med Chem Lett,CHEMBL3421646,0.01391,Yes,7.85667287
CHEMBL3424851,Inhibition of MK499 binding to human ERG,COc1nc2c(CCC34CCC(NCc5ccc6c(n5)NC(=O)CO6)(CC3)CO4)c(F)cnc2cc1F,Bioorg Med Chem Lett,CHEMBL3422952,0.00073,Yes,9.13667714
CHEMBL3424851,Inhibition of MK499 binding to human ERG,COc1cc(C)c2ncc(F)c(CCC34CCC(NCc5ccc6c(n5)NC(=O)CO6)(CC3)CO4)c2n1,Bioorg Med Chem Lett,CHEMBL3422953,0.0029,Yes,8.537602002
CHEMBL3424851,Inhibition of MK499 binding to human ERG,CCOc1cc(C)c2ncc(F)c(CCC34CCC(NCc5ccc6c(n5)NC(=O)CO6)(CC3)CO4)c2n1,Bioorg Med Chem Lett,CHEMBL3422954,0.00119,Yes,8.924453039
CHEMBL3424851,Inhibition of MK499 binding to human ERG,COc1nc2c(CCC34CCC(NCc5ccc6c(n5)NC(=O)CO6)(CC3)CO4)c(F)cnc2cc1C(F)(F)F,Bioorg Med Chem Lett,CHEMBL3422957,0.0017,Yes,8.769551079
CHEMBL3424851,Inhibition of MK499 binding to human ERG,Cc1cc(S(C)(=O)=O)nc2c(CCC34CCC(NCc5ccc6c(n5)NC(=O)CO6)(CC3)CO4)c(F)cnc12,Bioorg Med Chem Lett,CHEMBL3422958,0.01238,Yes,7.907279355
CHEMBL3424851,Inhibition of MK499 binding to human ERG,O=C1COc2ccc(CNC34CCC(CCc5c(F)cnc6cc(C(F)(F)F)cnc56)(CC3)OC4)nc2N1,Bioorg Med Chem Lett,CHEMBL3422959,0.00089,Yes,9.050609993
CHEMBL3424851,Inhibition of MK499 binding to human ERG,CN(C)c1cnc2c(CCC34CCC(NCc5ccc6c(n5)NC(=O)CO6)(CC3)CO4)c(F)cnc2c1,Bioorg Med Chem Lett,CHEMBL3422960,0.01837,Yes,7.735890844
CHEMBL3424851,Inhibition of MK499 binding to human ERG,O=C1COc2ccc(CNC34CCC(CCc5c(F)cnc6cc(Cl)cnc56)(CC3)OC4)nc2N1,Bioorg Med Chem Lett,CHEMBL3422961,0.00327,Yes,8.485452247
CHEMBL3424851,Inhibition of MK499 binding to human ERG,N#Cc1ccc2ncc(C#N)c(CCC34CCC(NCc5ccc6c(n5)NC(=O)CO6)(CC3)CO4)c2n1,Bioorg Med Chem Lett,CHEMBL3422962,0.00166,Yes,8.779891912
CHEMBL3424851,Inhibition of MK499 binding to human ERG,COc1nc2c(CCC34CCC(NCc5ccc6c(n5)NC(=O)CO6)(CC3)CO4)ccnc2cc1Cl,Bioorg Med Chem Lett,CHEMBL3422963,0.0042,Yes,8.37675071
CHEMBL3424851,Inhibition of MK499 binding to human ERG,COc1cc2nccc(CCC34CCC(NCc5ccc6c(n5)NC(=O)CO6)(CC3)CO4)c2nc1OC,Bioorg Med Chem Lett,CHEMBL3422964,0.00143,Yes,8.844663963
CHEMBL3424851,Inhibition of MK499 binding to human ERG,COc1nc2c(CCC34CCC(NCc5ccc6c(n5)NC(=O)CO6)(CC3)CO4)ccnc2cc1F,Bioorg Med Chem Lett,CHEMBL3422965,0.00249,Yes,8.603800653
CHEMBL3424851,Inhibition of MK499 binding to human ERG,COc1nc2c(CCC34CCC(NCc5ccc6c(n5)NC(=O)CO6)(CC3)CO4)ccnc2cc1C#N,Bioorg Med Chem Lett,CHEMBL3422966,0.0016,Yes,8.795880017
CHEMBL3424851,Inhibition of MK499 binding to human ERG,COc1cc(C)c2nccc(CCC34CCC(NCc5ccc6c(n5)NC(=O)CO6)(CC3)CO4)c2n1,Bioorg Med Chem Lett,CHEMBL3422967,0.00522,Yes,8.282329497
CHEMBL3424851,Inhibition of MK499 binding to human ERG,COc1cc(OC)c2nccc(CCC34CCC(NCc5ccc6c(n5)NC(=O)CO6)(CC3)CO4)c2n1,Bioorg Med Chem Lett,CHEMBL3422968,0.00178,Yes,8.749579998
CHEMBL3424851,Inhibition of MK499 binding to human ERG,COc1cc(CCC23CCC(NCc4ccc5c(n4)NC(=O)CO5)(CC2)CO3)c2nc(OC)ccc2n1,Bioorg Med Chem Lett,CHEMBL3422969,0.00421,Yes,8.375717904
CHEMBL3424851,Inhibition of MK499 binding to human ERG,Cc1nc2c(CCC34CCC(NCc5ccc6c(n5)NC(=O)CO6)(CC3)CO4)ccnc2cc1C#N,Bioorg Med Chem Lett,CHEMBL3422970,0.00087,Yes,9.060480747
CHEMBL3424851,Inhibition of MK499 binding to human ERG,COc1cc2nccc(CCC34CCC(NCc5ccc6c(n5)NC(=O)CO6)(CC3)CO4)c2nc1C#N,Bioorg Med Chem Lett,CHEMBL3422971,0.00196,Yes,8.707743929
CHEMBL3424851,Inhibition of MK499 binding to human ERG,COc1cc2nccc(CCC34CCC(NCc5ccc6c(n5)NC(=O)CO6)(CC3)CO4)c2nc1C(=O)O,Bioorg Med Chem Lett,CHEMBL3422972,0.01309,Yes,7.883060353
CHEMBL3424851,Inhibition of MK499 binding to human ERG,Cc1cc(C#N)nc2c(CCC34CCC(NCc5ccc6c(n5)NC(=O)CO6)(CC3)CO4)ccnc12,Bioorg Med Chem Lett,CHEMBL3422973,0.00208,Yes,8.681936665
CHEMBL3424851,Inhibition of MK499 binding to human ERG,Cc1cc(S(C)(=O)=O)nc2c(CCC34CCC(NCc5ccc6c(n5)NC(=O)CO6)(CC3)CO4)ccnc12,Bioorg Med Chem Lett,CHEMBL3422974,0.00671,Yes,8.17327748
CHEMBL3424851,Inhibition of MK499 binding to human ERG,CN(C)c1nc2c(CCC34CCC(NCc5ccc6c(n5)NC(=O)CO6)(CC3)CO4)ccnc2cc1C(F)(F)F,Bioorg Med Chem Lett,CHEMBL3422975,0.00229,Yes,8.640164518
CHEMBL3424851,Inhibition of MK499 binding to human ERG,CN(C)c1nc2c(CCC34CCC(NCc5ccc6c(n5)NC(=O)CO6)(CC3)CO4)ccnc2cc1F,Bioorg Med Chem Lett,CHEMBL3422976,0.00121,Yes,8.91721463
CHEMBL3424851,Inhibition of MK499 binding to human ERG,O=C1COc2ccc(CNC34CCC(CCc5ccnc6ccc(C(F)(F)F)nc56)(CC3)OC4)nc2N1,Bioorg Med Chem Lett,CHEMBL3422977,0.00099,Yes,9.004364805
CHEMBL3424851,Inhibition of MK499 binding to human ERG,O=C1COc2ccc(CNC34CCC(CCc5ccnc6cc(C(F)(F)F)cnc56)(CC3)OC4)nc2N1,Bioorg Med Chem Lett,CHEMBL3422978,0.00039,Yes,9.408935393
CHEMBL3424851,Inhibition of MK499 binding to human ERG,COc1cnc2c(CCC34CCC(NCc5ccc6c(n5)NC(=O)CO6)(CC3)CO4)ccnc2c1,Bioorg Med Chem Lett,CHEMBL3422979,0.01562,Yes,7.80631897
CHEMBL3424851,Inhibition of MK499 binding to human ERG,O=C1COc2ccc(CNC34CCC(CCc5ccnc6cc(Cl)cnc56)(CC3)OC4)nc2N1,Bioorg Med Chem Lett,CHEMBL3422980,0.00493,Yes,8.307153081
CHEMBL3424851,Inhibition of MK499 binding to human ERG,O=C1COc2ccc(CNC34CCC(CCc5ccnc6cc(F)cnc56)(CC3)OC4)nc2N1,Bioorg Med Chem Lett,CHEMBL3422981,0.01675,Yes,7.775985189
CHEMBL3424851,Inhibition of MK499 binding to human ERG,CCOC(=O)c1c(OC)cnc2c(CCC34CCC(NCc5ccc6c(n5)NC(=O)CO6)(CC3)CO4)ccnc12,Bioorg Med Chem Lett,CHEMBL3422982,0.00787,Yes,8.104025268
CHEMBL3424851,Inhibition of MK499 binding to human ERG,COc1ccc2ncc(C#N)c(CC(O)C34CCC(NCc5ccc6c(n5)NC(=O)CO6)(CC3)CO4)c2n1,Bioorg Med Chem Lett,CHEMBL3422983,0.00213,Yes,8.671620397
CHEMBL3424851,Inhibition of MK499 binding to human ERG,COc1ccc2ncc(C#N)c(CC(O)C34CCC(NCc5ccc6c(n5)NC(=O)CO6)(CC3)CO4)c2n1,Bioorg Med Chem Lett,CHEMBL3422983,0.00258,Yes,8.588380294
CHEMBL3424852,Inhibition of human ERG expressed in CHO cells by Patch express assay,COc1ccc2ncc(F)c(CCC34CCC(NCc5ccc6c(n5)NC(=O)CO6)(CC3)CO4)c2n1,Bioorg Med Chem Lett,CHEMBL3305005,0.6,Yes,6.22184875
CHEMBL3424852,Inhibition of human ERG expressed in CHO cells by Patch express assay,COc1ccc2ncc(C(F)(F)F)c(CCC34CCC(NCc5ccc6c(n5)NC(=O)CO6)(CC3)CO4)c2n1,Bioorg Med Chem Lett,CHEMBL3422757,0.73,Yes,6.13667714
CHEMBL3424851,Inhibition of MK499 binding to human ERG,COc1ccc2ncc(F)c(C[C@H](O)C34CCC(NCc5ccc6c(n5)NC(=O)CO6)(CC3)CO4)c2n1,Bioorg Med Chem Lett,CHEMBL3305167,0.026,Yes,7.585026652
CHEMBL3424852,Inhibition of human ERG expressed in CHO cells by Patch express assay,COc1ccc2ncc(F)c(C[C@H](O)C34CCC(NCc5ccc6c(n5)NC(=O)CO6)(CC3)CO4)c2n1,Bioorg Med Chem Lett,CHEMBL3305167,0.018,Yes,7.744727495
CHEMBL3428449,Displacement of MK499 from human ERG,O=c1ccc2ncc(F)c3c2n1C[C@@]3(O)CC12CCC(NC/C=C/c3c(F)cccc3F)(CC1)CO2,Bioorg Med Chem Lett,CHEMBL3425934,0.032,Yes,7.494850022
CHEMBL3428449,Displacement of MK499 from human ERG,O=c1ccc2ncc(F)c3c2n1C[C@@]3(O)CC12CCC(NC/C=C/c3cc(F)ccc3F)(CC1)CO2,Bioorg Med Chem Lett,CHEMBL3425935,0.008,Yes,8.096910013
CHEMBL3428449,Displacement of MK499 from human ERG,O=c1ccc2ncc(F)c3c2n1C[C@@]3(O)CC12CCC(NC/C=C/c3ccc(F)cc3)(CC1)CO2,Bioorg Med Chem Lett,CHEMBL3425936,0.064,Yes,7.193820026
CHEMBL3428449,Displacement of MK499 from human ERG,O=c1ccc2ncc(F)c3c2n1C[C@@]3(O)CC12CCC(NC/C(F)=C\c3cc(F)ccc3F)(CC1)CO2,Bioorg Med Chem Lett,CHEMBL3425937,0.016,Yes,7.795880017
CHEMBL3428449,Displacement of MK499 from human ERG,O=c1ccc2ncc(F)c3c2n1C[C@@]3(O)CC12CCC(NC/C(F)=C/c3cc(F)ccc3F)(CC1)CO2,Bioorg Med Chem Lett,CHEMBL3425938,0.016,Yes,7.795880017
CHEMBL3428449,Displacement of MK499 from human ERG,O=c1ccc2ncc(F)c3c2n1C[C@@]3(O)CC12CCC(NC/C=C/c3ccccc3)(CC1)CO2,Bioorg Med Chem Lett,CHEMBL3425939,0.064,Yes,7.193820026
CHEMBL3428449,Displacement of MK499 from human ERG,O=c1ccc2ncc(F)c3c2n1C[C@@]3(O)CC12CCC(NC/C=C/c3ccccn3)(CC1)CO2,Bioorg Med Chem Lett,CHEMBL3425940,0.064,Yes,7.193820026
CHEMBL3428449,Displacement of MK499 from human ERG,O=c1ccc2ncc(F)c3c2n1C[C@@]3(O)CC12CCC(NCCCc3cc(F)ccc3F)(CC1)CO2,Bioorg Med Chem Lett,CHEMBL3425941,0.032,Yes,7.494850022
CHEMBL3428449,Displacement of MK499 from human ERG,O=c1ccc2ncc(F)c3c2n1C[C@@]3(O)CC12CCC(NCOc3cc(F)ccc3F)(CC1)CO2,Bioorg Med Chem Lett,CHEMBL3425942,0.064,Yes,7.193820026
CHEMBL3428449,Displacement of MK499 from human ERG,O=c1ccc2ncc(F)c3c2n1C[C@@]3(O)CC12CCC(NCc3cc(-c4cccs4)on3)(CC1)CO2,Bioorg Med Chem Lett,CHEMBL3425943,0.016,Yes,7.795880017
CHEMBL3428450,Inhibition of human ERG expressed in CHO cells measured over 5 mins by patch clamp assay,O=C1COc2ccc(CNC34CCC(C[C@]5(O)Cn6c(=O)ccc7ncc(F)c5c76)(CC3)OC4)nc2N1,Bioorg Med Chem Lett,CHEMBL3400817,174,No,3.759450752
CHEMBL3428450,Inhibition of human ERG expressed in CHO cells measured over 5 mins by patch clamp assay,O=C1COc2cc(F)c(CNC34CCC(C[C@]5(O)Cn6c(=O)ccc7ncc(F)c5c76)(CC3)OC4)nc2N1,Bioorg Med Chem Lett,CHEMBL3425799,333,No,3.477555766
CHEMBL3428450,Inhibition of human ERG expressed in CHO cells measured over 5 mins by patch clamp assay,O=C1COc2cc(Cl)c(CNC34CCC(C[C@]5(O)Cn6c(=O)ccc7ncc(F)c5c76)(CC3)OC4)nc2N1,Bioorg Med Chem Lett,CHEMBL3425800,126,No,3.899629455
CHEMBL3428450,Inhibition of human ERG expressed in CHO cells measured over 5 mins by patch clamp assay,O=C1COc2cc(OC(=O)c3ccccc3)c(CNC34CCC(C[C@]5(O)Cn6c(=O)ccc7ncc(F)c5c76)(CC3)OC4)nc2N1,Bioorg Med Chem Lett,CHEMBL3425805,30.5,No,4.515700161
CHEMBL3428450,Inhibition of human ERG expressed in CHO cells measured over 5 mins by patch clamp assay,O=c1ccc2ncc(F)c3c2n1C[C@@]3(O)CC12CCC(NCc3cc4c(cn3)OCCO4)(CC1)CO2,Bioorg Med Chem Lett,CHEMBL3425810,764,No,3.116906641
CHEMBL3428450,Inhibition of human ERG expressed in CHO cells measured over 5 mins by patch clamp assay,O=c1ccc2ncc(F)c3c2n1C[C@@]3(O)CC12CCC(NCc3c(Cl)cc4c(c3Cl)OCCO4)(CC1)CO2,Bioorg Med Chem Lett,CHEMBL3425825,30.4,No,4.517126416
CHEMBL3428450,Inhibition of human ERG expressed in CHO cells measured over 5 mins by patch clamp assay,O=c1ccc2ncc(F)c3c2n1C[C@@]3(O)CC12CCC(NCc3cc4c(c(Cl)c3Cl)OCCO4)(CC1)CO2,Bioorg Med Chem Lett,CHEMBL3425826,31.6,No,4.500312917
CHEMBL3428450,Inhibition of human ERG expressed in CHO cells measured over 5 mins by patch clamp assay,CN1CCN(C)c2nc(CNC34CCC(C[C@]5(O)Cn6c(=O)ccc7ncc(F)c5c76)(CC3)OC4)ccc21,Bioorg Med Chem Lett,CHEMBL3425929,30.6,No,4.514278574
CHEMBL3428450,Inhibition of human ERG expressed in CHO cells measured over 5 mins by patch clamp assay,O=c1ccc2ncc(F)c3c2n1C[C@@]3(O)CC12CCC(NCc3cc4c(cn3)OCS4)(CC1)CO2,Bioorg Med Chem Lett,CHEMBL3425932,33.6,No,4.473660723
CHEMBL3428458,Inhibition of human ERG,O=c1ccc2ncc(=O)n3c2n1C[C@H]3CN1CCC(NCc2cc3c(cn2)OCCC3)CC1,Bioorg Med Chem Lett,CHEMBL3317856,1400,No,2.853871964
CHEMBL3430628,Inhibition of potassium current (Ikr) measured using whole-cell patch clamp experiments in HEK-293 cells stable transfected with hERG cDNA,CCCCc1oc2ccccc2c1C(=O)c1cc(I)c(OCCN(CC)CC)c(I)c1,Cardiovasc Res,CHEMBL633,0.03,Yes,7.522878745
CHEMBL3430630,Inhibition of hERG K channel,CC(C)COCC(CN(Cc1ccccc1)c1ccccc1)N1CCCC1,Cardiovasc Res,CHEMBL1008,0.033,Yes,7.48148606
CHEMBL3430633,Inhibition of hERG K channel,COc1cc(N)c(Cl)cc1C(=O)NC1CCN(CCCOc2ccc(F)cc2)CC1OC,Cardiovasc Res,CHEMBL1729,0.0065,Yes,8.187086643
CHEMBL3430637,Inhibition of hERG K channel,CN(CCOc1ccc(NS(C)(=O)=O)cc1)CCc1ccc(NS(C)(=O)=O)cc1,Cardiovasc Res,CHEMBL473,0.005,Yes,8.301029996
CHEMBL3430639,Inhibition of hERG K channel,O=C(CCCN1CCC(O)(c2ccc(Cl)cc2)CC1)c1ccc(F)cc1,Cardiovasc Res,CHEMBL54,0.027,Yes,7.568636236
CHEMBL3430643,Inhibition of hERG K channel,COC(=O)C1=C(C)NC(C)=C(C(=O)OC)C1c1ccccc1[N+](=O)[O-],Cardiovasc Res,CHEMBL193,275,No,3.560667306
CHEMBL3430645,Inhibition of hERG K channel,O=C1NC(=O)C(c2ccccc2)(c2ccccc2)N1,Cardiovasc Res,CHEMBL16,100,No,4
CHEMBL3430646,Inhibition of hERG K channel,O=c1[nH]c2ccccc2n1C1CCN(CCCC(c2ccc(F)cc2)c2ccc(F)cc2)CC1,Cardiovasc Res,CHEMBL1423,0.02,Yes,7.698970004
CHEMBL3430647,Inhibition of potassium current (Ikr) measured using whole-cell patch clamp experiments in HEK-293 cells stable transfected with hERG cDNA,CC(Cc1ccccc1)NCCC(c1ccccc1)c1ccccc1,Cardiovasc Res,CHEMBL24072,0.065,Yes,7.187086643
CHEMBL3430648,Inhibition of hERG K channel,CCCNCC(O)COc1ccccc1C(=O)CCc1ccccc1,Cardiovasc Res,CHEMBL631,0.44,Yes,6.356547324
CHEMBL3430651,Inhibition of hERG K channel,C=C[C@H]1CN2CC[C@H]1C[C@@H]2[C@@H](O)c1ccnc2ccc(OC)cc12,Cardiovasc Res,CHEMBL1294,0.3,Yes,6.522878745
CHEMBL3430652,Inhibition of hERG K channel,Cc1nc2n(c(=O)c1CCN1CCC(c3noc4cc(F)ccc34)CC1)CCCC2,Cardiovasc Res,CHEMBL85,0.15,Yes,6.823908741
CHEMBL3430653,Inhibition of hERG K channel,O=C1NCCN1CCN1CCC(c2cn(-c3ccc(F)cc3)c3ccc(Cl)cc23)CC1,Cardiovasc Res,CHEMBL12713,0.014,Yes,7.853871964
CHEMBL3430655,Inhibition of hERG K channel,CC(C)(C)c1ccc(C(O)CCCN2CCC(C(O)(c3ccccc3)c3ccccc3)CC2)cc1,Cardiovasc Res,CHEMBL17157,0.0089,Yes,8.050609993
CHEMBL3430656,Inhibition of hERG K channel,CSc1ccc2c(c1)N(CCC1CCCCN1C)c1ccccc1S2,Cardiovasc Res,CHEMBL479,0.033,Yes,7.48148606
CHEMBL3430657,Inhibition of hERG K channel,COc1ccc(CCN(C)CCCC(C#N)(c2ccc(OC)c(OC)c2)C(C)C)cc1OC,Cardiovasc Res,CHEMBL6966,0.143,Yes,6.844663963
CHEMBL3430690,Inhibition of rapid delayed inward rectifying potassium current (IKr) in Chinese hamster ovary (CHO) K1 cells stably expressing hERG measured using IonWorks Quattro automated patch clamp platform,C[C@H]1CN(C[C@H](Cc2ccccc2)C(=O)NCC(=O)O)CC[C@@]1(C)c1cccc(O)c1,J Pharmacol Toxicol Methods,CHEMBL270190,63095.73445,No,1.2
CHEMBL3430691,Inhibition of rapid delayed inward rectifying potassium current (IKr) in Chinese hamster ovary (CHO) K1 cells stably expressing hERG measured using IonWorks Quattro automated patch clamp platform,COC(c1ccccc1)(c1ccccc1)[C@H](Oc1nc(C)cc(C)n1)C(=O)O,J Pharmacol Toxicol Methods,CHEMBL1111,7943.28235,No,2.1
CHEMBL3430693,Inhibition of rapid delayed inward rectifying potassium current (IKr) in Chinese hamster ovary (CHO) K1 cells stably expressing hERG measured using IonWorks Quattro automated patch clamp platform,CC(C)CN(C[C@@H](O)[C@H](Cc1ccccc1)NC(=O)O[C@H]1CO[C@H]2OCC[C@H]21)S(=O)(=O)c1ccc(N)cc1,J Pharmacol Toxicol Methods,CHEMBL1323,63.09573,No,4.200000031
CHEMBL3430694,Inhibition of rapid delayed inward rectifying potassium current (IKr) in Chinese hamster ovary (CHO) K1 cells stably expressing hERG measured using IonWorks Quattro automated patch clamp platform,Cc1nc(Nc2ncc(C(=O)Nc3c(C)cccc3Cl)s2)cc(N2CCN(CCO)CC2)n1,J Pharmacol Toxicol Methods,CHEMBL1421,50.11872,No,4.300000029
CHEMBL3430696,Inhibition of rapid delayed inward rectifying potassium current (IKr) in Chinese hamster ovary (CHO) K1 cells stably expressing hERG measured using IonWorks Quattro automated patch clamp platform,CN(C)CC(c1ccc(O)cc1)C1(O)CCCCC1,J Pharmacol Toxicol Methods,CHEMBL1118,19952.62315,No,1.7
CHEMBL3430697,Inhibition of rapid delayed inward rectifying potassium current (IKr) in Chinese hamster ovary (CHO) K1 cells stably expressing hERG measured using IonWorks Quattro automated patch clamp platform,CN(CCOc1ccc(NS(C)(=O)=O)cc1)CCc1ccc(NS(C)(=O)=O)cc1,J Pharmacol Toxicol Methods,CHEMBL473,0.12589,Yes,6.900008766
CHEMBL3430698,Inhibition of rapid delayed inward rectifying potassium current (IKr) in Chinese hamster ovary (CHO) K1 cells stably expressing hERG measured using IonWorks Quattro automated patch clamp platform,C[C@@H](O)[C@H]1C(=O)N2C(C(=O)O)=C(S[C@@H]3CN[C@H](CNS(N)(=O)=O)C3)[C@H](C)[C@H]12,J Pharmacol Toxicol Methods,CHEMBL491571,7943.28235,No,2.1
CHEMBL3430701,Inhibition of rapid delayed inward rectifying potassium current (IKr) in Chinese hamster ovary (CHO) K1 cells stably expressing hERG measured using IonWorks Quattro automated patch clamp platform,Cc1cc(C#N)cc(C)c1Oc1nc(Nc2ccc(C#N)cc2)nc(N)c1Br,J Pharmacol Toxicol Methods,CHEMBL308954,398.10717,No,3.400000001
CHEMBL3430702,Inhibition of rapid delayed inward rectifying potassium current (IKr) in Chinese hamster ovary (CHO) K1 cells stably expressing hERG measured using IonWorks Quattro automated patch clamp platform,CO[C@H]1C[C@@H]2CC[C@@H](C)[C@@](O)(O2)C(=O)C(=O)N2CCCC[C@H]2C(=O)O[C@H]([C@H](C)C[C@@H]2CC[C@@H](OCCO)[C@H](OC)C2)CC(=O)[C@H](C)/C=C(\C)[C@@H](O)[C@@H](OC)C(=O)[C@H](C)C[C@H](C)/C=C/C=C/C=C/1C,J Pharmacol Toxicol Methods,CHEMBL1908360,15848.93192,No,1.8
CHEMBL3430704,Inhibition of rapid delayed inward rectifying potassium current (IKr) in Chinese hamster ovary (CHO) K1 cells stably expressing hERG measured using IonWorks Quattro automated patch clamp platform,Nc1nnc(-c2cccc(Cl)c2Cl)c(N)n1,J Pharmacol Toxicol Methods,CHEMBL741,398.10717,No,3.400000001
CHEMBL3430705,Inhibition of rapid delayed inward rectifying potassium current (IKr) in Chinese hamster ovary (CHO) K1 cells stably expressing hERG measured using IonWorks Quattro automated patch clamp platform,CS(=O)(=O)CCNCc1ccc(-c2ccc3ncnc(Nc4ccc(OCc5cccc(F)c5)c(Cl)c4)c3c2)o1,J Pharmacol Toxicol Methods,CHEMBL554,100000,No,1
CHEMBL3430706,Inhibition of rapid delayed inward rectifying potassium current (IKr) in Chinese hamster ovary (CHO) K1 cells stably expressing hERG measured using IonWorks Quattro automated patch clamp platform,Cc1nnc(C(C)C)n1[C@@H]1C[C@H]2CC[C@@H](C1)N2CC[C@H](NC(=O)C1CCC(F)(F)CC1)c1ccccc1,J Pharmacol Toxicol Methods,CHEMBL1201187,125.89254,No,3.900000004
CHEMBL3430707,Inhibition of rapid delayed inward rectifying potassium current (IKr) in Chinese hamster ovary (CHO) K1 cells stably expressing hERG measured using IonWorks Quattro automated patch clamp platform,COc1c(N2C[C@@H]3CCCN[C@@H]3C2)c(F)cc2c(=O)c(C(=O)O)cn(C3CC3)c12,J Pharmacol Toxicol Methods,CHEMBL32,398.10717,No,3.400000001
CHEMBL3430709,Inhibition of rapid delayed inward rectifying potassium current (IKr) in Chinese hamster ovary (CHO) K1 cells stably expressing hERG measured using IonWorks Quattro automated patch clamp platform,Cc1c(O)cccc1C(=O)N[C@@H](CSc1ccccc1)[C@H](O)CN1C[C@H]2CCCC[C@H]2C[C@H]1C(=O)NC(C)(C)C,J Pharmacol Toxicol Methods,CHEMBL584,31622.7766,No,1.5
CHEMBL3430710,Inhibition of rapid delayed inward rectifying potassium current (IKr) in Chinese hamster ovary (CHO) K1 cells stably expressing hERG measured using IonWorks Quattro automated patch clamp platform,Cc1cn(-c2cc(NC(=O)c3ccc(C)c(Nc4nccc(-c5cccnc5)n4)c3)cc(C(F)(F)F)c2)cn1,J Pharmacol Toxicol Methods,CHEMBL255863,63.09573,No,4.200000031
CHEMBL3430713,Inhibition of rapid delayed inward rectifying potassium current (IKr) in Chinese hamster ovary (CHO) K1 cells stably expressing hERG measured using IonWorks Quattro automated patch clamp platform,Cc1nnc(C(=O)NC(C)(C)c2nc(C(=O)NCc3ccc(F)cc3)c(O)c(=O)n2C)o1,J Pharmacol Toxicol Methods,CHEMBL254316,3162.27766,No,2.5
CHEMBL3430714,Inhibition of rapid delayed inward rectifying potassium current (IKr) in Chinese hamster ovary (CHO) K1 cells stably expressing hERG measured using IonWorks Quattro automated patch clamp platform,CCCc1nn(C)c2c(=O)[nH]c(-c3cc(S(=O)(=O)N4CCN(C)CC4)ccc3OCC)nc12,J Pharmacol Toxicol Methods,CHEMBL192,158.48932,No,3.799999998
CHEMBL3430716,Inhibition of rapid delayed inward rectifying potassium current (IKr) in Chinese hamster ovary (CHO) K1 cells stably expressing hERG measured using IonWorks Quattro automated patch clamp platform,N[C@@H](CC(=O)N1CCn2c(nnc2C(F)(F)F)C1)Cc1cc(F)c(F)cc1F,J Pharmacol Toxicol Methods,CHEMBL1422,1000,No,3
CHEMBL3430719,Inhibition of rapid delayed inward rectifying potassium current (IKr) in Chinese hamster ovary (CHO) K1 cells stably expressing hERG measured using IonWorks Quattro automated patch clamp platform,CN1CC(=O)N2[C@H](c3ccc4c(c3)OCO4)c3[nH]c4ccccc4c3C[C@@H]2C1=O,J Pharmacol Toxicol Methods,CHEMBL779,79.43282,No,4.100000019
CHEMBL3430720,Inhibition of rapid delayed inward rectifying potassium current (IKr) in Chinese hamster ovary (CHO) K1 cells stably expressing hERG measured using IonWorks Quattro automated patch clamp platform,Cc1cn([C@@H]2C[C@@H](O)[C@H](CO)O2)c(=O)[nH]c1=O,J Pharmacol Toxicol Methods,CHEMBL374731,5011.87234,No,2.3
CHEMBL3430721,Inhibition of rapid delayed inward rectifying potassium current (IKr) in Chinese hamster ovary (CHO) K1 cells stably expressing hERG measured using IonWorks Quattro automated patch clamp platform,Cc1ccc(O)c([C@H](CCN(C(C)C)C(C)C)c2ccccc2)c1,J Pharmacol Toxicol Methods,CHEMBL1382,0.12589,Yes,6.900008766
CHEMBL3430722,Inhibition of rapid delayed inward rectifying potassium current (IKr) in Chinese hamster ovary (CHO) K1 cells stably expressing hERG measured using IonWorks Quattro automated patch clamp platform,CCCc1nc(C)c2c(=O)nc(-c3cc(S(=O)(=O)N4CCN(CC)CC4)ccc3OCC)[nH]n12,J Pharmacol Toxicol Methods,CHEMBL1520,316.22777,No,3.499999995
CHEMBL3430725,Inhibition of rapid delayed inward rectifying potassium current (IKr) in Chinese hamster ovary (CHO) cells stable expressing hERG measured using IonWorks Barracuda automated patch clamp platform,CC(C)CN(C[C@@H](O)[C@H](Cc1ccccc1)NC(=O)O[C@H]1CO[C@H]2OCC[C@H]21)S(=O)(=O)c1ccc(N)cc1,J Pharmacol Toxicol Methods,CHEMBL1323,100,No,4
CHEMBL3430726,Inhibition of rapid delayed inward rectifying potassium current (IKr) in Chinese hamster ovary (CHO) cells stable expressing hERG measured using IonWorks Barracuda automated patch clamp platform,Cc1nc(Nc2ncc(C(=O)Nc3c(C)cccc3Cl)s2)cc(N2CCN(CCO)CC2)n1,J Pharmacol Toxicol Methods,CHEMBL1421,50.11872,No,4.300000029
CHEMBL3430729,Inhibition of rapid delayed inward rectifying potassium current (IKr) in Chinese hamster ovary (CHO) cells stable expressing hERG measured using IonWorks Barracuda automated patch clamp platform,CN(CCOc1ccc(NS(C)(=O)=O)cc1)CCc1ccc(NS(C)(=O)=O)cc1,J Pharmacol Toxicol Methods,CHEMBL473,0.63096,Yes,6.199998172
CHEMBL3430731,Inhibition of rapid delayed inward rectifying potassium current (IKr) in Chinese hamster ovary (CHO) cells stable expressing hERG measured using IonWorks Barracuda automated patch clamp platform,CC1=NN(c2ccc(C)c(C)c2)C(=O)/C1=N\Nc1cccc(-c2cccc(C(=O)O)c2)c1O,J Pharmacol Toxicol Methods,CHEMBL461101,1584.89319,No,2.800000001
CHEMBL3430733,Inhibition of rapid delayed inward rectifying potassium current (IKr) in Chinese hamster ovary (CHO) cells stable expressing hERG measured using IonWorks Barracuda automated patch clamp platform,CO[C@H]1C[C@@H]2CC[C@@H](C)[C@@](O)(O2)C(=O)C(=O)N2CCCC[C@H]2C(=O)O[C@H]([C@H](C)C[C@@H]2CC[C@@H](OCCO)[C@H](OC)C2)CC(=O)[C@H](C)/C=C(\C)[C@@H](O)[C@@H](OC)C(=O)[C@H](C)C[C@H](C)/C=C/C=C/C=C/1C,J Pharmacol Toxicol Methods,CHEMBL1908360,794.32823,No,3.100000003
CHEMBL3430734,Inhibition of rapid delayed inward rectifying potassium current (IKr) in Chinese hamster ovary (CHO) cells stable expressing hERG measured using IonWorks Barracuda automated patch clamp platform,Nc1nnc(-c2cccc(Cl)c2Cl)c(N)n1,J Pharmacol Toxicol Methods,CHEMBL741,251.18864,No,3.600000005
CHEMBL3430735,Inhibition of rapid delayed inward rectifying potassium current (IKr) in Chinese hamster ovary (CHO) cells stable expressing hERG measured using IonWorks Barracuda automated patch clamp platform,CS(=O)(=O)CCNCc1ccc(-c2ccc3ncnc(Nc4ccc(OCc5cccc(F)c5)c(Cl)c4)c3c2)o1,J Pharmacol Toxicol Methods,CHEMBL554,630.95734,No,3.200000003
CHEMBL3430736,Inhibition of rapid delayed inward rectifying potassium current (IKr) in Chinese hamster ovary (CHO) cells stable expressing hERG measured using IonWorks Barracuda automated patch clamp platform,Cc1nnc(C(C)C)n1[C@@H]1C[C@H]2CC[C@@H](C1)N2CC[C@H](NC(=O)C1CCC(F)(F)CC1)c1ccccc1,J Pharmacol Toxicol Methods,CHEMBL1201187,79.43282,No,4.100000019
CHEMBL3430739,Inhibition of rapid delayed inward rectifying potassium current (IKr) in Chinese hamster ovary (CHO) cells stable expressing hERG measured using IonWorks Barracuda automated patch clamp platform,Cc1c(O)cccc1C(=O)N[C@@H](CSc1ccccc1)[C@H](O)CN1C[C@H]2CCCC[C@H]2C[C@H]1C(=O)NC(C)(C)C,J Pharmacol Toxicol Methods,CHEMBL584,501.18723,No,3.300000003
CHEMBL3430742,Inhibition of rapid delayed inward rectifying potassium current (IKr) in Chinese hamster ovary (CHO) cells stable expressing hERG measured using IonWorks Barracuda automated patch clamp platform,Cc1nnc(C(=O)NC(C)(C)c2nc(C(=O)NCc3ccc(F)cc3)c(O)c(=O)n2C)o1,J Pharmacol Toxicol Methods,CHEMBL254316,316.22777,No,3.499999995
CHEMBL3430743,Inhibition of rapid delayed inward rectifying potassium current (IKr) in Chinese hamster ovary (CHO) cells stable expressing hERG measured using IonWorks Barracuda automated patch clamp platform,CCCc1nn(C)c2c(=O)[nH]c(-c3cc(S(=O)(=O)N4CCN(C)CC4)ccc3OCC)nc12,J Pharmacol Toxicol Methods,CHEMBL192,100,No,4
CHEMBL3430744,Inhibition of rapid delayed inward rectifying potassium current (IKr) in Chinese hamster ovary (CHO) cells stable expressing hERG measured using IonWorks Barracuda automated patch clamp platform,N[C@@H](CC(=O)N1CCn2c(nnc2C(F)(F)F)C1)Cc1cc(F)c(F)cc1F,J Pharmacol Toxicol Methods,CHEMBL1422,501.18723,No,3.300000003
CHEMBL3430746,Inhibition of rapid delayed inward rectifying potassium current (IKr) in Chinese hamster ovary (CHO) cells stable expressing hERG measured using IonWorks Barracuda automated patch clamp platform,CN1CC(=O)N2[C@H](c3ccc4c(c3)OCO4)c3[nH]c4ccccc4c3C[C@@H]2C1=O,J Pharmacol Toxicol Methods,CHEMBL779,125.89254,No,3.900000004
CHEMBL3430747,Inhibition of rapid delayed inward rectifying potassium current (IKr) in Chinese hamster ovary (CHO) cells stable expressing hERG measured using IonWorks Barracuda automated patch clamp platform,Cc1ccc(O)c([C@H](CCN(C(C)C)C(C)C)c2ccccc2)c1,J Pharmacol Toxicol Methods,CHEMBL1382,0.15849,Yes,6.799998135
CHEMBL3430748,Inhibition of rapid delayed inward rectifying potassium current (IKr) in Chinese hamster ovary (CHO) cells stable expressing hERG measured using IonWorks Barracuda automated patch clamp platform,CCCc1nc(C)c2c(=O)nc(-c3cc(S(=O)(=O)N4CCN(CC)CC4)ccc3OCC)[nH]n12,J Pharmacol Toxicol Methods,CHEMBL1520,79.43282,No,4.100000019
CHEMBL3430749,Inhibition of rapid delayed inward rectifying potassium current (IKr) measured using manual patch clamp assay,COc1cc2nc(N(C)CCCNC(=O)C3CCCO3)nc(N)c2cc1OC,J Pharmacol Toxicol Methods,CHEMBL709,125.89254,No,3.900000004
CHEMBL3430750,Inhibition of rapid delayed inward rectifying potassium current (IKr) measured using manual patch clamp assay,C[C@H]1CN(C[C@H](Cc2ccccc2)C(=O)NCC(=O)O)CC[C@@]1(C)c1cccc(O)c1,J Pharmacol Toxicol Methods,CHEMBL270190,794.32823,No,3.100000003
CHEMBL3430322,Inhibition of rapid delayed inward rectifying potassium current (IKr) measured using manual patch clamp assay,COC(c1ccccc1)(c1ccccc1)[C@H](Oc1nc(C)cc(C)n1)C(=O)O,J Pharmacol Toxicol Methods,CHEMBL1111,501.18723,No,3.300000003
CHEMBL3430323,Inhibition of rapid delayed inward rectifying potassium current (IKr) measured using manual patch clamp assay,NC(=O)C(c1ccccc1)(c1ccccc1)[C@@H]1CCN(CCc2ccc3c(c2)CCO3)C1,J Pharmacol Toxicol Methods,CHEMBL1346,0.07943,Yes,7.100015437
CHEMBL3430324,Inhibition of rapid delayed inward rectifying potassium current (IKr) measured using manual patch clamp assay,CC(C)CN(C[C@@H](O)[C@H](Cc1ccccc1)NC(=O)O[C@H]1CO[C@H]2OCC[C@H]21)S(=O)(=O)c1ccc(N)cc1,J Pharmacol Toxicol Methods,CHEMBL1323,158.48932,No,3.799999998
CHEMBL3430326,Inhibition of rapid delayed inward rectifying potassium current (IKr) measured using manual patch clamp assay,O=C(O)c1ccc(-n2nc(-c3ccccc3O)nc2-c2ccccc2O)cc1,J Pharmacol Toxicol Methods,CHEMBL550348,3981.07171,No,2.4
CHEMBL3430327,Inhibition of rapid delayed inward rectifying potassium current (IKr) measured using manual patch clamp assay,CN(C)CC(c1ccc(O)cc1)C1(O)CCCCC1,J Pharmacol Toxicol Methods,CHEMBL1118,251.18864,No,3.600000005
CHEMBL3430328,Inhibition of rapid delayed inward rectifying potassium current (IKr) measured using manual patch clamp assay,CN(CCOc1ccc(NS(C)(=O)=O)cc1)CCc1ccc(NS(C)(=O)=O)cc1,J Pharmacol Toxicol Methods,CHEMBL473,0.01,Yes,8
CHEMBL3430329,Inhibition of rapid delayed inward rectifying potassium current (IKr) measured using manual patch clamp assay,C[C@@H](O)[C@H]1C(=O)N2C(C(=O)O)=C(S[C@@H]3CN[C@H](CNS(N)(=O)=O)C3)[C@H](C)[C@H]12,J Pharmacol Toxicol Methods,CHEMBL491571,5011.87234,No,2.3
CHEMBL3430331,Inhibition of rapid delayed inward rectifying potassium current (IKr) measured using manual patch clamp assay,CC1=NN(c2ccc(C)c(C)c2)C(=O)/C1=N\Nc1cccc(-c2cccc(C(=O)O)c2)c1O,J Pharmacol Toxicol Methods,CHEMBL461101,0.63096,Yes,6.199998172
CHEMBL3430332,Inhibition of rapid delayed inward rectifying potassium current (IKr) measured using manual patch clamp assay,Cc1cc(C#N)cc(C)c1Oc1nc(Nc2ccc(C#N)cc2)nc(N)c1Br,J Pharmacol Toxicol Methods,CHEMBL308954,158.48932,No,3.799999998
CHEMBL3430333,Inhibition of rapid delayed inward rectifying potassium current (IKr) measured using manual patch clamp assay,CO[C@H]1C[C@@H]2CC[C@@H](C)[C@@](O)(O2)C(=O)C(=O)N2CCCC[C@H]2C(=O)O[C@H]([C@H](C)C[C@@H]2CC[C@@H](OCCO)[C@H](OC)C2)CC(=O)[C@H](C)/C=C(\C)[C@@H](O)[C@@H](OC)C(=O)[C@H](C)C[C@H](C)/C=C/C=C/C=C/1C,J Pharmacol Toxicol Methods,CHEMBL1908360,501.18723,No,3.300000003
CHEMBL3430334,Inhibition of rapid delayed inward rectifying potassium current (IKr) measured using manual patch clamp assay,COC[C@@H](NC(C)=O)C(=O)NCc1ccccc1,J Pharmacol Toxicol Methods,CHEMBL58323,50118.72336,No,1.3
CHEMBL3430335,Inhibition of rapid delayed inward rectifying potassium current (IKr) measured using manual patch clamp assay,Nc1nnc(-c2cccc(Cl)c2Cl)c(N)n1,J Pharmacol Toxicol Methods,CHEMBL741,251.18864,No,3.600000005
CHEMBL3430337,Inhibition of rapid delayed inward rectifying potassium current (IKr) measured using manual patch clamp assay,Cc1nnc(C(C)C)n1[C@@H]1C[C@H]2CC[C@@H](C1)N2CC[C@H](NC(=O)C1CCC(F)(F)CC1)c1ccccc1,J Pharmacol Toxicol Methods,CHEMBL1201187,39.81072,No,4.399999968
CHEMBL3430338,Inhibition of rapid delayed inward rectifying potassium current (IKr) measured using manual patch clamp assay,COc1c(N2C[C@@H]3CCCN[C@@H]3C2)c(F)cc2c(=O)c(C(=O)O)cn(C3CC3)c12,J Pharmacol Toxicol Methods,CHEMBL32,79.43282,No,4.100000019
CHEMBL3430339,Inhibition of rapid delayed inward rectifying potassium current (IKr) measured using manual patch clamp assay,OC(CNCC(O)C1CCc2cc(F)ccc2O1)C1CCc2cc(F)ccc2O1,J Pharmacol Toxicol Methods,CHEMBL434394,0.31623,Yes,6.499996932
CHEMBL3430341,Inhibition of rapid delayed inward rectifying potassium current (IKr) measured using manual patch clamp assay,Cc1cn(-c2cc(NC(=O)c3ccc(C)c(Nc4nccc(-c5cccnc5)n4)c3)cc(C(F)(F)F)c2)cn1,J Pharmacol Toxicol Methods,CHEMBL255863,0.12589,Yes,6.900008766
CHEMBL3430344,Inhibition of rapid delayed inward rectifying potassium current (IKr) measured using manual patch clamp assay,Cc1nnc(C(=O)NC(C)(C)c2nc(C(=O)NCc3ccc(F)cc3)c(O)c(=O)n2C)o1,J Pharmacol Toxicol Methods,CHEMBL254316,1584.89319,No,2.800000001
CHEMBL3430345,Inhibition of rapid delayed inward rectifying potassium current (IKr) measured using manual patch clamp assay,CCCc1nn(C)c2c(=O)[nH]c(-c3cc(S(=O)(=O)N4CCN(C)CC4)ccc3OCC)nc12,J Pharmacol Toxicol Methods,CHEMBL192,31.62278,No,4.499999953
CHEMBL3430347,Inhibition of rapid delayed inward rectifying potassium current (IKr) measured using manual patch clamp assay,N[C@@H](CC(=O)N1CCn2c(nnc2C(F)(F)F)C1)Cc1cc(F)c(F)cc1F,J Pharmacol Toxicol Methods,CHEMBL1422,158.48932,No,3.799999998
CHEMBL3430348,Inhibition of rapid delayed inward rectifying potassium current (IKr) measured using manual patch clamp assay,O=C(O[C@H]1CN2CCC1CC2)N1CCc2ccccc2[C@@H]1c1ccccc1,J Pharmacol Toxicol Methods,CHEMBL1734,0.25119,Yes,6.599997654
CHEMBL3430349,Inhibition of rapid delayed inward rectifying potassium current (IKr) measured using manual patch clamp assay,CCN(CC)CCNC(=O)c1c(C)[nH]c(/C=C2\C(=O)Nc3ccc(F)cc32)c1C,J Pharmacol Toxicol Methods,CHEMBL535,0.25119,Yes,6.599997654
CHEMBL3430350,Inhibition of rapid delayed inward rectifying potassium current (IKr) measured using manual patch clamp assay,CN1CC(=O)N2[C@H](c3ccc4c(c3)OCO4)c3[nH]c4ccccc4c3C[C@@H]2C1=O,J Pharmacol Toxicol Methods,CHEMBL779,100,No,4
CHEMBL3430351,Inhibition of rapid delayed inward rectifying potassium current (IKr) measured using manual patch clamp assay,Cc1cn([C@@H]2C[C@@H](O)[C@H](CO)O2)c(=O)[nH]c1=O,J Pharmacol Toxicol Methods,CHEMBL374731,158489.3193,No,1
CHEMBL3430352,Inhibition of rapid delayed inward rectifying potassium current (IKr) measured using manual patch clamp assay,Cc1ccc(O)c([C@H](CCN(C(C)C)C(C)C)c2ccccc2)c1,J Pharmacol Toxicol Methods,CHEMBL1382,0.01259,Yes,7.89997427
CHEMBL3430353,Inhibition of rapid delayed inward rectifying potassium current (IKr) measured using manual patch clamp assay,CCCc1nc(C)c2c(=O)nc(-c3cc(S(=O)(=O)N4CCN(CC)CC4)ccc3OCC)[nH]n12,J Pharmacol Toxicol Methods,CHEMBL1520,31.62278,No,4.499999953
CHEMBL3579786,Inhibition of human ERG expressed in HEK293 cells by FLIPR based flux assay,CCC[C@@H]1C[C@H](N(C)C(C)C)CC[C@@H]1NC(=O)CNC(=O)c1cccc(C(F)(F)F)c1,ACS Med Chem Lett,CHEMBL3577935,32,No,4.494850022
CHEMBL3579786,Inhibition of human ERG expressed in HEK293 cells by FLIPR based flux assay,CCCC[C@@H]1C[C@H](N(C)C(C)C)CC[C@@H]1NC(=O)CNC(=O)c1cccc(C(F)(F)F)c1,ACS Med Chem Lett,CHEMBL3577937,0.36,Yes,6.443697499
CHEMBL3582736,Inhibition of human ERG expressed in CHO cells assessed as whole cell current by patch clamp assay,COc1cc(N)c(Cl)cc1C(=O)NC1CCN(CCCOc2ccc(F)cc2)CC1OC,J Med Chem,CHEMBL1729,0.04,Yes,7.397940009
CHEMBL3583096,Inhibition of human ERG channel,CNC(=O)c1ccc(-c2cc(F)c3ncc(Cc4ccc5ncccc5c4)n3c2)cc1F,ACS Med Chem Lett,CHEMBL3582294,93.56,No,4.028909787
CHEMBL3583383,Inhibition of MK499 binding to human ERG,Cn1cc([C@@]2(c3ccc(C(=O)O)cn3)N[C@@H](c3nc(-c4ccc(F)cc4)c[nH]3)Cc3c2[nH]c2ccccc32)cn1,ACS Med Chem Lett,CHEMBL3323086,95.6,No,4.019542108
CHEMBL3583383,Inhibition of MK499 binding to human ERG,c1ccc(-c2c[nH]c([C@H]3Cc4c([nH]c5ccccc45)C(C4CCCCC4)N3)n2)nc1,ACS Med Chem Lett,CHEMBL3582312,0.2,Yes,6.698970004
CHEMBL3583383,Inhibition of MK499 binding to human ERG,c1cncc(-c2c[nH]c([C@H]3Cc4c([nH]c5ccccc45)C(C4CCCCC4)N3)n2)c1,ACS Med Chem Lett,CHEMBL3582313,0.19,Yes,6.721246399
CHEMBL3583383,Inhibition of MK499 binding to human ERG,c1ccc2c3c([nH]c2c1)C(C1CCCCC1)N[C@@H](c1nc(-c2ccncc2)c[nH]1)C3,ACS Med Chem Lett,CHEMBL3582314,0.09,Yes,7.045757491
CHEMBL3583383,Inhibition of MK499 binding to human ERG,c1ccc2c3c([nH]c2c1)C(C1CCCCC1)N[C@@H](c1nc(-c2cnccn2)c[nH]1)C3,ACS Med Chem Lett,CHEMBL3582315,0.34,Yes,6.468521083
CHEMBL3583383,Inhibition of MK499 binding to human ERG,Fc1ccc(-c2c[nH]c([C@H]3Cc4c([nH]c5ccccc45)C(C4CCCCC4)N3)n2)nc1,ACS Med Chem Lett,CHEMBL3582316,0.17,Yes,6.769551079
CHEMBL3583383,Inhibition of MK499 binding to human ERG,Cn1cc([C@@]2(c3nnc(N)o3)N[C@@H](c3nc(-c4ccc(F)cn4)c[nH]3)Cc3c2[nH]c2ccccc32)cn1,ACS Med Chem Lett,CHEMBL3582330,35.4,No,4.450996738
CHEMBL3583383,Inhibition of MK499 binding to human ERG,CCn1nc([C@]2(c3cnn(C)c3)N[C@@H](c3nc(-c4ccc(F)cn4)c[nH]3)Cc3c2[nH]c2ccccc32)oc1=O,ACS Med Chem Lett,CHEMBL3580681,51.5,No,4.288192771
CHEMBL3583383,Inhibition of MK499 binding to human ERG,CCn1cc([C@@]2(c3nn(C)c(=O)o3)N[C@@H](c3nc(-c4ccc(F)cn4)c[nH]3)Cc3c2[nH]c2ccccc32)cn1,ACS Med Chem Lett,CHEMBL3582336,32.2,No,4.492144128
CHEMBL3583383,Inhibition of MK499 binding to human ERG,CCn1cc(C2(c3nn(C)c(=O)o3)N[C@@H](c3nc(-c4ccc(F)cn4)c[nH]3)Cc3c2[nH]c2ccccc32)cn1,ACS Med Chem Lett,CHEMBL3582337,39.9,No,4.399027104
CHEMBL3583383,Inhibition of MK499 binding to human ERG,CCn1cc([C@@]2(c3nn(CC(=O)O)c(=O)o3)N[C@@H](c3nc(-c4ccc(F)cn4)c[nH]3)Cc3c2[nH]c2ccccc32)cn1,ACS Med Chem Lett,CHEMBL3582343,30.5,No,4.515700161
CHEMBL3583383,Inhibition of MK499 binding to human ERG,CCn1cc([C@@]2(c3nn(CC(N)=O)c(=O)o3)N[C@@H](c3nc(-c4ccc(F)cn4)c[nH]3)Cc3c2[nH]c2ccccc32)cn1,ACS Med Chem Lett,CHEMBL3582344,34.5,No,4.462180905
CHEMBL3587475,Inhibition of human ERG,CO[C@H]1CC[C@H](N2C(=O)CNc3ncc(-c4ccc(C(C)(C)O)nc4)nc32)CC1,J Med Chem,CHEMBL3586404,33,No,4.48148606
CHEMBL3591528,Inhibition of human ERG by PatchXpress assay,O=C(NCC[C@@H](O)CN1CCN(c2cccc(Cl)c2Cl)CC1)c1cc2ccccc2[nH]1,J Med Chem,CHEMBL1627306,0.38,Yes,6.420216403
CHEMBL3591518,Inhibition of human Kv11.1 expressed in HEK293 cells assessed as inhibition of channel tail current at holding potential -80 mV by whole cell voltage clamp assay,CCCCCCCN(CC)CC#CC(c1ccccc1)c1ccccc1,J Med Chem,CHEMBL3093972,0.182,Yes,6.739928612
CHEMBL3591518,Inhibition of human Kv11.1 expressed in HEK293 cells assessed as inhibition of channel tail current at holding potential -80 mV by whole cell voltage clamp assay,C[n+]1c(C#Cc2ccc(-c3ccccc3)cc2)cccc1C#Cc1ccc(-c2ccccc2)cc1,J Med Chem,CHEMBL2325212,0.107,Yes,6.970616222
CHEMBL3598727,Inhibition of [35S]MK499 binding to human ERG channel,COc1ccccc1N1CCN(Cc2nc3c4cccc(OC)c4nc(N)n3n2)[C@H](C)C1,Bioorg Med Chem Lett,CHEMBL3596511,47.6,No,4.322393047
CHEMBL3598727,Inhibition of [35S]MK499 binding to human ERG channel,COc1cccc2c1nc(N)n1nc(CN3CCN(c4ccccc4F)C[C@H]3C)nc21,Bioorg Med Chem Lett,CHEMBL3596503,49.97,No,4.301290651
CHEMBL3598727,Inhibition of [35S]MK499 binding to human ERG channel,COc1cccc2c1nc(N)n1nc(CN3CCN(c4ncc(C)s4)C[C@H]3C)nc21,Bioorg Med Chem Lett,CHEMBL3596515,47.03,No,4.327625021
CHEMBL3598727,Inhibition of [35S]MK499 binding to human ERG channel,CCn1cc(N2CCN(Cc3nc4c5cccc(OC)c5nc(N)n4n3)[C@H](C)C2)cn1,Bioorg Med Chem Lett,CHEMBL3596589,39.19,No,4.406824737
CHEMBL3602657,Inhibition of human ERG overexpressed in CHO cells by Qpatch method,COc1cc(N)c(Cl)cc1C(=O)NC1CCN(CCCOc2ccc(F)cc2)CC1OC,Bioorg Med Chem,CHEMBL1729,0.098,Yes,7.008773924
CHEMBL3607786,Inhibition of MK499 binding to human ERG,COc1ccc2ncc(F)c(CCC34CCC(NCc5cc(C)c6c(n5)NC(=O)CO6)(CC3)CO4)c2n1,Bioorg Med Chem Lett,CHEMBL3604691,0.3,Yes,6.522878745
CHEMBL3607786,Inhibition of MK499 binding to human ERG,COc1ccc2ncc(F)c(CCC34CCC(NCc5nc6c(c(C)c5C)OCC(=O)N6)(CC3)CO4)c2n1,Bioorg Med Chem Lett,CHEMBL3604692,0.5,Yes,6.301029996
CHEMBL3607786,Inhibition of MK499 binding to human ERG,CCc1c(CNC23CCC(CCc4c(F)cnc5ccc(OC)nc45)(CC2)OC3)nc2c(c1C)OCC(=O)N2,Bioorg Med Chem Lett,CHEMBL3604693,0.7,Yes,6.15490196
CHEMBL3607786,Inhibition of MK499 binding to human ERG,C=Cc1c(CNC23CCC(CCc4c(F)cnc5ccc(OC)nc45)(CC2)OC3)nc2c(c1C)OCC(=O)N2,Bioorg Med Chem Lett,CHEMBL3604797,0.5,Yes,6.301029996
CHEMBL3607786,Inhibition of MK499 binding to human ERG,COc1ccc2ncc(F)c(CCC34CCC(NCc5nc6c(c(C)c5F)OCC(=O)N6)(CC3)CO4)c2n1,Bioorg Med Chem Lett,CHEMBL3604798,0.9,Yes,6.045757491
CHEMBL3607786,Inhibition of MK499 binding to human ERG,COc1ccc2ncc(F)c(CCC34CCC(NCc5ccc6c(n5)NC(=O)C(C)O6)(CC3)CO4)c2n1,Bioorg Med Chem Lett,CHEMBL3604799,0.8,Yes,6.096910013
CHEMBL3607786,Inhibition of MK499 binding to human ERG,COc1ccc2ncc(F)c(CCC34CCC(NCc5ccc6c(n5)N(C)C(=O)CO6)(CC3)CO4)c2n1,Bioorg Med Chem Lett,CHEMBL3604802,0.8,Yes,6.096910013
CHEMBL3607787,Inhibition of human ERG expressed in CHO cells measured for 5 mins by automated patch clamp assay,COc1ccc2ncc(F)c(CCC34CCC(NCc5ccc6c(n5)NC(=O)CO6)(CC3)CO4)c2n1,Bioorg Med Chem Lett,CHEMBL3305005,0.6,Yes,6.22184875
CHEMBL3607755,Inhibition of human ERG,Cc1cc(NCc2c(Cl)ccc(Cl)c2Cl)c2cccc(C(N)=O)c2n1,J Med Chem,CHEMBL3604735,0.50119,Yes,6.299997603
CHEMBL3607755,Inhibition of human ERG,Cc1cc(NCc2c(F)cccc2C(F)(F)F)c2cccc(C(N)=O)c2n1,J Med Chem,CHEMBL3604734,0.39811,Yes,6.399996913
CHEMBL3607755,Inhibition of human ERG,Cc1cc(NCc2c(C)cccc2C)c2cccc(C(N)=O)c2n1,J Med Chem,CHEMBL3604701,0.50119,Yes,6.299997603
CHEMBL3607541,Inhibition of human ERG assessed as reduction in MK499 competitive binding,CCOc1ccc2ncc(F)c(CCC34CCC(NCc5ccc6c(n5)NC(=O)CO6)(CC3)CO4)c2n1,Bioorg Med Chem Lett,CHEMBL3605140,0.4,Yes,6.397940009
CHEMBL3607541,Inhibition of human ERG assessed as reduction in MK499 competitive binding,O=C1COc2ccc(CNC34CCC(CCc5c(F)cnc6ccc(OC7CCC7)nc56)(CC3)OC4)nc2N1,Bioorg Med Chem Lett,CHEMBL3605145,0.5,Yes,6.301029996
CHEMBL3607541,Inhibition of human ERG assessed as reduction in MK499 competitive binding,O=C1COc2ccc(CNC34CCC(CCc5c(F)cnc6ccc(OC(F)F)nc56)(CC3)OC4)nc2N1,Bioorg Med Chem Lett,CHEMBL3605147,0.7,Yes,6.15490196
CHEMBL3607541,Inhibition of human ERG assessed as reduction in MK499 competitive binding,O=C1COc2ccc(CNC34CCC(CCc5c(F)cnc6ccc(OCCCCCO)nc56)(CC3)OC4)nc2N1,Bioorg Med Chem Lett,CHEMBL3605123,0.7,Yes,6.15490196
CHEMBL3607541,Inhibition of human ERG assessed as reduction in MK499 competitive binding,NC1CC1COc1ccc2ncc(F)c(CCC34CCC(NCc5ccc6c(n5)NC(=O)CO6)(CC3)CO4)c2n1,Bioorg Med Chem Lett,CHEMBL3605139,0.2,Yes,6.698970004
CHEMBL3607541,Inhibition of human ERG assessed as reduction in MK499 competitive binding,N[C@@H]1C(=O)NC[C@H]1Oc1ccc2ncc(F)c(CCC34CCC(NCc5ccc6c(n5)NC(=O)CO6)(CC3)CO4)c2n1,Bioorg Med Chem Lett,CHEMBL3605023,39.9,No,4.399027104
CHEMBL3607541,Inhibition of human ERG assessed as reduction in MK499 competitive binding,COC(=O)CCCCOc1ccc2ncc(F)c(CCC34CCC(NCc5ccc6c(n5)NC(=O)CO6)(CC3)CO4)c2n1,Bioorg Med Chem Lett,CHEMBL3605119,0.4,Yes,6.397940009
CHEMBL3607541,Inhibition of human ERG assessed as reduction in MK499 competitive binding,O=C(O)CCCCOc1ccc2ncc(F)c(CCC34CCC(NCc5ccc6c(n5)NC(=O)CO6)(CC3)CO4)c2n1,Bioorg Med Chem Lett,CHEMBL3604999,43.5,No,4.361510743
CHEMBL3607541,Inhibition of human ERG assessed as reduction in MK499 competitive binding,COC(=O)[C@@H]1C[C@@H]1COc1ccc2ncc(F)c(CCC34CCC(NCc5ccc6c(n5)NC(=O)CO6)(CC3)CO4)c2n1,Bioorg Med Chem Lett,CHEMBL3605002,0.6,Yes,6.22184875
CHEMBL3607541,Inhibition of human ERG assessed as reduction in MK499 competitive binding,COC(=O)[C@H]1C[C@@H]1COc1ccc2ncc(F)c(CCC34CCC(NCc5ccc6c(n5)NC(=O)CO6)(CC3)CO4)c2n1,Bioorg Med Chem Lett,CHEMBL3605004,0.5,Yes,6.301029996
CHEMBL3607541,Inhibition of human ERG assessed as reduction in MK499 competitive binding,O=C1COc2ccc(CNC34CCC(CCc5c(F)cnc6ccc(OC[C@H]7C[C@@H]7C(=O)O)nc56)(CC3)OC4)nc2N1,Bioorg Med Chem Lett,CHEMBL3605005,43.4,No,4.36251027
CHEMBL3607541,Inhibition of human ERG assessed as reduction in MK499 competitive binding,O=C1COc2ccc(CNC34CCC(CCc5c(F)cnc6ccc(OCCc7cc(=O)c(O)c[nH]7)nc56)(CC3)OC4)nc2N1,Bioorg Med Chem Lett,CHEMBL3605012,0.9,Yes,6.045757491
CHEMBL3610078,Inhibition of human ERG,Cc1nsc(-c2nnc3n2CCN(C(=O)c2ccc(F)cc2)C3)n1,ACS Med Chem Lett,CHEMBL3608684,50,No,4.301029996
CHEMBL3610078,Inhibition of human ERG,Cc1nsc(-c2nnc3n2CCN(C(=O)c2ccc(Cl)cc2)[C@@H]3C)n1,ACS Med Chem Lett,CHEMBL3608687,66,No,4.180456064
CHEMBL3610078,Inhibition of human ERG,C[C@@H]1c2nnc(-c3nc(C(F)(F)F)ns3)n2CCN1C(=O)c1ccc(F)cc1,ACS Med Chem Lett,CHEMBL3608688,39,No,4.408935393
CHEMBL3610078,Inhibition of human ERG,Cc1nsc(-c2nnc3n2CCN(C(=O)c2ccccc2)[C@@H]3C)n1,ACS Med Chem Lett,CHEMBL3608740,50,No,4.301029996
CHEMBL3610078,Inhibition of human ERG,Cc1nsc(-c2nnc3n2CCN(C(=O)c2ccc(F)cc2)[C@@H]3CCO)n1,ACS Med Chem Lett,CHEMBL3608741,50,No,4.301029996
CHEMBL3610296,Inhibition of human ERG by IonWorks assay,Cc1ncc(CNC2CCN(CCn3c(=O)ccc4ncc(Oc5ccc(S(N)(=O)=O)cc5)cc43)CC2)cc1Cl,ACS Med Chem Lett,CHEMBL3608744,82,No,4.086186148
CHEMBL3610296,Inhibition of human ERG by IonWorks assay,O=C1COc2ccc(CNC3CCN(CCn4c(=O)ccc5ncc(Oc6cncc(F)c6)cc54)CC3)nc2N1,ACS Med Chem Lett,CHEMBL3608750,79,No,4.102372909
CHEMBL3610296,Inhibition of human ERG by IonWorks assay,O=C1COc2ccc(CN[C@@H]3CCN(CCn4c(=O)ccc5ncc(Oc6cccnc6)cc54)C[C@@H]3F)nc2N1,ACS Med Chem Lett,CHEMBL3608757,75,No,4.124938737
CHEMBL3611641,Binding affinity to human ERG expressed in HEK cells by MK-499 radioligand displacement assay,COc1cc(-c2cn(C3CCc4c(ccc5ccccc45)N(CC(F)(F)F)C3=O)nn2)ccc1-n1cnc(C)c1,Bioorg Med Chem Lett,CHEMBL3609635,0.9,Yes,6.045757491
CHEMBL3611641,Binding affinity to human ERG expressed in HEK cells by MK-499 radioligand displacement assay,COc1cc(-c2cn(C3CCc4c(ccc(Br)c4F)N(CC(F)(F)F)C3=O)nn2)ccc1-n1cnc(C)c1,Bioorg Med Chem Lett,CHEMBL3609639,0.53,Yes,6.27572413
CHEMBL3615683,Displacement of [35S]-MK499 from human ERG expressed in HEK293 cells,N#Cc1ccc(CCN2CCN(CCc3ccc4c(c3)COC4=O)CC2)cc1,ACS Med Chem Lett,CHEMBL2146871,0.43,Yes,6.366531544
CHEMBL3615683,Displacement of [35S]-MK499 from human ERG expressed in HEK293 cells,N#Cc1ccc(CCN2CCN(CCc3ccc([N+](=O)[O-])cc3)CC2)cc1,ACS Med Chem Lett,CHEMBL2146757,0.009,Yes,8.045757491
CHEMBL3615683,Displacement of [35S]-MK499 from human ERG expressed in HEK293 cells,O=C1OCc2cc(CCN3CCN(CCc4ccc([N+](=O)[O-])cc4)CC3)ccc21,ACS Med Chem Lett,CHEMBL3612795,0.15,Yes,6.823908741
CHEMBL3615686,Inhibition of human ERG expressed in HEK293 cells by electrophysiology assay,COc1cc([C@@H](O)CN2CCN(C[C@H](O)c3ccc4c(c3C)COC4=O)CC2)ncc1C#N,ACS Med Chem Lett,CHEMBL3612810,33,No,4.48148606
CHEMBL3620197,Inhibition of human ERG expressed in CHO cells by patch clamp electrophysiology assay,Nc1nc(NC2CCNCC2)c2sc(-c3ccc(C(F)(F)F)cc3)cc2n1,J Med Chem,CHEMBL3617353,0.9,Yes,6.045757491
CHEMBL3620197,Inhibition of human ERG expressed in CHO cells by patch clamp electrophysiology assay,Nc1nc(NC2CCOCC2)c2sc(-c3ccc(C(F)(F)F)cc3)cc2n1,J Med Chem,CHEMBL3617454,0.7,Yes,6.15490196
CHEMBL3630432,Inhibition of human ERG by thallium flux assay,N/C1=N\C(=O)[C@@H]2CCCN2c2ccc(cc2)OCCCCCCNCC(=O)Nc2c(Cl)cc(cc2Cl)CN1,Bioorg Med Chem Lett,CHEMBL3628128,32,No,4.494850022
CHEMBL3631371,Inhibition of human ERG potassium channel by ionworks patch-clamp electrophysiology assay,CS(=O)(=O)c1ccc(-c2cnc3ccc(-c4cccc(S(C)(=O)=O)c4)nn23)cc1,J Med Chem,CHEMBL3234071,0.9,Yes,6.045757491
CHEMBL3631371,Inhibition of human ERG potassium channel by ionworks patch-clamp electrophysiology assay,CS(=O)(=O)c1ccc(-c2cnc3ccc(-c4cccc(S(=O)(=O)C5CC5)c4)nn23)cc1,J Med Chem,CHEMBL3355639,0.4,Yes,6.397940009
CHEMBL3631371,Inhibition of human ERG potassium channel by ionworks patch-clamp electrophysiology assay,CS(=O)(=O)c1ccc(-c2cnn3ccc(-c4cccc(S(=O)(=O)C5CC5)c4)nc23)cc1,J Med Chem,CHEMBL3628223,0.5,Yes,6.301029996
CHEMBL3635896,Inhibition of human ERG expressed in HEK293 cells by whole-cell patch clamp method,O=C(c1ccc(F)cc1F)C1CCN(CCCOc2ccc(-c3nc4ccccc4o3)cc2)CC1,Bioorg Med Chem Lett,CHEMBL3634812,0.85,Yes,6.070581074
CHEMBL3635896,Inhibition of human ERG expressed in HEK293 cells by whole-cell patch clamp method,Fc1ccc2c(C3CCN(CCCOc4ccc(CCc5nc6ccccc6o5)cc4)CC3)noc2c1,Bioorg Med Chem Lett,CHEMBL3634824,0.63,Yes,6.200659451
CHEMBL3738365,Inhibition of human ERG assessed as reduction in IKr current,CS(=O)(=O)n1cc2c(n1)CN([C@H]1CO[C@H](c3cc(F)ccc3F)[C@@H](N)C1)C2,Bioorg Med Chem Lett,CHEMBL2105762,39,No,4.408935393
CHEMBL3736641,Inhibition of human ERG by patch clamp technique,CCOC[C@]12Cc3cnn(-c4ccc(F)cc4)c3C=C1CCN(S(=O)(=O)c1ccc(C(F)(F)F)cc1)C2,Bioorg Med Chem Lett,CHEMBL271220,0.8,Yes,6.096910013
CHEMBL3736641,Inhibition of human ERG by patch clamp technique,O=C(c1ccccn1)[C@]12Cc3cnn(-c4ccc(F)cc4)c3C=C1CCN(S(=O)(=O)c1ccc(F)cc1)C2,Bioorg Med Chem Lett,CHEMBL3735376,0.98,Yes,6.008773924
CHEMBL3744556,Inhibition of human ERG,CN1CCN(C2=Nc3cc(Cl)ccc3Nc3ccccc32)CC1,Medchemcomm,CHEMBL42,0.901,Yes,6.045275209
CHEMBL3744556,Inhibition of human ERG,Cc1nc2n(c(=O)c1CCN1CCC(c3noc4cc(F)ccc34)CC1)CCCC2,Medchemcomm,CHEMBL85,0.778,Yes,6.109020403
CHEMBL3745212,Inhibition of human ERG expressed in HEK293 cells by patch clamp assay,O=C(c1ccc(Cl)c(C(F)(F)F)c1)N1CCN(c2cc(=O)[nH]c(=O)n2Cc2ccc(OS(=O)(=O)c3cccc4cnccc34)cc2)CC1,Eur J Med Chem,CHEMBL3741159,47.8,No,4.320572103
CHEMBL3744630,Displacement of doferilide from human ERG,O=C(O)C1CN(Cc2ccc(OCc3ccc(Cl)c(Cl)c3)cc2)C1,J Med Chem,CHEMBL3741589,77,No,4.113509275
CHEMBL3750698,Inhibition of human ERG by IKr binding assay,O=C(c1ccc(C[C@@H]2CC[C@H]([C@H](O)c3ccccc3)N2)cc1)N1CCC2(CCOC2=O)CC1,Bioorg Med Chem Lett,CHEMBL3747244,46,No,4.337242168
CHEMBL3750698,Inhibition of human ERG by IKr binding assay,CC1(C)CC2(CCN(C(=O)c3ccc(C[C@@H]4CC[C@H]([C@H](O)c5ccccc5)N4)cc3)CC2)C(=O)O1,Bioorg Med Chem Lett,CHEMBL3746280,31,No,4.508638306
CHEMBL3750698,Inhibition of human ERG by IKr binding assay,O=C(c1ccc(C[C@@H]2CC[C@H]([C@H](O)c3ccccc3)N2)cc1)N1C[C@@H]2[C@H](C1)[C@H]2c1nnco1,Bioorg Med Chem Lett,CHEMBL3747356,55,No,4.259637311
CHEMBL3750698,Inhibition of human ERG by IKr binding assay,CCc1nnc([C@H]2[C@@H]3CN(C(=O)c4ccc(C[C@@H]5CC[C@H]([C@H](O)c6ccccc6)N5)cc4)C[C@@H]32)o1,Bioorg Med Chem Lett,CHEMBL3747455,36,No,4.443697499
CHEMBL3755637,Displacement of MK499 from human ERG,COc1ccc2ncc(F)c([C@@H](O)[C@H](O)C34CCC(NCc5ccc6c(n5)NC(=O)CO6)(CC3)CO4)c2n1,Medchemcomm,CHEMBL3753988,60,No,4.22184875
CHEMBL3755637,Displacement of MK499 from human ERG,COc1ccc2ncc(F)c([C@H](O)[C@@H](O)C34CCC(NCc5ccc6c(n5)NC(=O)CO6)(CC3)CO4)c2n1,Medchemcomm,CHEMBL3753718,36.1,No,4.442492798
CHEMBL3762781,Inhibition of human ERG by FLIPR assay,COc1ccc2c(c1)[C@@H]1C[C@]1(C(=O)N1C3CCC1CN(C)C3)Cn1c-2c(C2CCCCC2)c2ccc(C(=O)NS(=O)(=O)C(C)C)cc21,Bioorg Med Chem Lett,CHEMBL3758288,40.9,No,4.388276692
CHEMBL3762781,Inhibition of human ERG by FLIPR assay,COc1ccc2c(c1)[C@@H]1C[C@]1(C(=O)N1C3CCC1CN(C)C3)Cn1c-2c(C2CCCCC2)c2ccc(C(=O)NS(=O)(=O)C3CCC3)cc21,Bioorg Med Chem Lett,CHEMBL3759768,38.1,No,4.419075024
CHEMBL3761681,Inhibition of human ERG,Cc1nc(NC(=O)c2cc(CNC(=O)C(C)C)cnc2C(F)F)[nH]c1-c1ccc(C(F)(F)F)cc1,J Med Chem,CHEMBL3342693,82.6,No,4.083019953
CHEMBL3767769,Binding affinity to human ERG channel,O=S(=O)(Nc1ccc(CCNC[C@H](O)c2cccnc2)cc1)c1ccc(-c2nc(-c3ccc(C(F)(F)F)cc3)cs2)cc1,J Med Chem,CHEMBL111201,0.22,Yes,6.657577319
CHEMBL3768879,Inhibition of human ERG expressed in HEK293 cells by thallium flux assay,CC1(C)CCc2cc(S(=O)(=O)N(CC(=O)O)C3(c4cccc(-c5cc(Cl)cc(Cl)c5)c4)CCC3)ccc2O1,Bioorg Med Chem,CHEMBL3764017,40,No,4.397940009
CHEMBL3773319,Inhibition of human ERG channel tail current,CC1=NN(c2ccc(C)c(C)c2)C(=O)/C1=N\Nc1cccc(-c2cccc(C(=O)O)c2)c1O,Bioorg Med Chem,CHEMBL461101,0.69,Yes,6.161150909
CHEMBL3776609,Inhibition of human ERG tail current expressed in HEK293 cells after 5 mins by patch clamp assay,Cn1c(SCCCN2CC3CCN(c4ccc(C(F)(F)F)cc4)C3C2)nnc1-c1ccc(=O)n(C)c1,Bioorg Med Chem,CHEMBL3774769,0.25119,Yes,6.599997654
CHEMBL3776609,Inhibition of human ERG tail current expressed in HEK293 cells after 5 mins by patch clamp assay,Cn1c(SCCCN2CC3CCN(c4ccc(C(F)(F)F)cc4)C3C2)nnc1N1CCOCC1,Bioorg Med Chem,CHEMBL3775243,0.12589,Yes,6.900008766
CHEMBL3776609,Inhibition of human ERG tail current expressed in HEK293 cells after 5 mins by patch clamp assay,Cn1c(SCCCN2CC3CCN(c4ccc(C(F)(F)F)cc4)C3C2)nnc1N1CCOCC1,Bioorg Med Chem,CHEMBL3775243,0.50119,Yes,6.299997603
CHEMBL3776609,Inhibition of human ERG tail current expressed in HEK293 cells after 5 mins by patch clamp assay,Cn1c(SCCCN2CC3CCN(c4ccc(F)cc4)C3C2)nnc1C1CCOCC1,Bioorg Med Chem,CHEMBL3775737,0.79433,Yes,6.099999035
CHEMBL3776609,Inhibition of human ERG tail current expressed in HEK293 cells after 5 mins by patch clamp assay,Cn1c(SCCCN2CC3CCN(c4ccc(C(F)(F)F)cc4)C3C2)nnc1C1CCCC1,Bioorg Med Chem,CHEMBL3774462,0.19953,Yes,6.699991797
CHEMBL3776609,Inhibition of human ERG tail current expressed in HEK293 cells after 5 mins by patch clamp assay,Cn1c(SCCCN2CC3CCN(c4ccc(C(F)(F)F)cc4)C3C2)nnc1C1CCCCC1,Bioorg Med Chem,CHEMBL3774463,0.31623,Yes,6.499996932
CHEMBL3776609,Inhibition of human ERG tail current expressed in HEK293 cells after 5 mins by patch clamp assay,Cn1c(SCCCN2CC3CCN(c4ccc(F)cc4)C3C2)nnc1C1CCCCC1,Bioorg Med Chem,CHEMBL3774431,0.31623,Yes,6.499996932
CHEMBL3776609,Inhibition of human ERG tail current expressed in HEK293 cells after 5 mins by patch clamp assay,Cc1ncoc1-c1nnc(SCCCN2CC3CN(c4ccc(C(F)(F)F)cc4)C3C2)n1C,Bioorg Med Chem,CHEMBL3774515,0.63096,Yes,6.199998172
CHEMBL3776609,Inhibition of human ERG tail current expressed in HEK293 cells after 5 mins by patch clamp assay,Cn1c(SCCCN2CC3CCN(c4ccccc4C(F)(F)F)C3C2)nnc1-c1ccccn1,Bioorg Med Chem,CHEMBL3775408,0.63096,Yes,6.199998172
CHEMBL3776609,Inhibition of human ERG tail current expressed in HEK293 cells after 5 mins by patch clamp assay,Cn1c(SCCCN2CC3CCN(c4ccc(C(F)(F)F)cc4)C3C2)nnc1-c1ccccn1,Bioorg Med Chem,CHEMBL3775554,0.15849,Yes,6.799998135
CHEMBL3776609,Inhibition of human ERG tail current expressed in HEK293 cells after 5 mins by patch clamp assay,Cn1c(SCCCN2CC3CCN(c4ccc(C(F)(F)F)cc4)C3C2)nnc1-c1cccnc1,Bioorg Med Chem,CHEMBL3775604,0.12589,Yes,6.900008766
CHEMBL3776609,Inhibition of human ERG tail current expressed in HEK293 cells after 5 mins by patch clamp assay,Cn1cc(-c2nnc(SCCCN3CC4CCN(c5ccc(C(F)(F)F)cc5)C4C3)n2C)cn1,Bioorg Med Chem,CHEMBL3775036,0.15849,Yes,6.799998135
CHEMBL3776609,Inhibition of human ERG tail current expressed in HEK293 cells after 5 mins by patch clamp assay,Cn1c(SCCCN2CC3CCN(c4ccc(C(F)(F)F)cc4)C3C2)nnc1-c1cccnn1,Bioorg Med Chem,CHEMBL3775583,0.12589,Yes,6.900008766
CHEMBL3776609,Inhibition of human ERG tail current expressed in HEK293 cells after 5 mins by patch clamp assay,Cn1c(SCCCN2CC3CCN(c4ccc(C(F)(F)F)cc4)C3C2)nnc1-c1ccncn1,Bioorg Med Chem,CHEMBL3775810,0.1,Yes,7
CHEMBL3776609,Inhibition of human ERG tail current expressed in HEK293 cells after 5 mins by patch clamp assay,Cn1c(SCCCN2CC3CCN(c4ccc(C(F)(F)F)cc4)C3C2)nnc1-c1cncnc1,Bioorg Med Chem,CHEMBL3775572,0.15849,Yes,6.799998135
CHEMBL3776609,Inhibition of human ERG tail current expressed in HEK293 cells after 5 mins by patch clamp assay,Cn1c(SCCCN2CC3CCN(c4c(F)cc(F)cc4F)C3C2)nnc1-c1cnccn1,Bioorg Med Chem,CHEMBL3774519,0.50119,Yes,6.299997603
CHEMBL3776609,Inhibition of human ERG tail current expressed in HEK293 cells after 5 mins by patch clamp assay,COc1cc(N2CCC3CN(CCCSc4nnc(-c5cnccn5)n4C)CC32)ccc1F,Bioorg Med Chem,CHEMBL3775753,0.39811,Yes,6.399996913
CHEMBL3776609,Inhibition of human ERG tail current expressed in HEK293 cells after 5 mins by patch clamp assay,Cn1c(SCCCN2CC3CCN(c4ccc(F)cc4F)C3C2)nnc1-c1cnccn1,Bioorg Med Chem,CHEMBL3774591,0.79433,Yes,6.099999035
CHEMBL3776609,Inhibition of human ERG tail current expressed in HEK293 cells after 5 mins by patch clamp assay,Cn1c(SCCCN2CC3CCN(c4ccccc4C#N)C3C2)nnc1-c1cnccn1,Bioorg Med Chem,CHEMBL3775631,0.19953,Yes,6.699991797
CHEMBL3776609,Inhibition of human ERG tail current expressed in HEK293 cells after 5 mins by patch clamp assay,Cn1c(SCCCN2CC3CCN(c4cccc(C#N)c4)C3C2)nnc1-c1cnccn1,Bioorg Med Chem,CHEMBL3775667,0.1,Yes,7
CHEMBL3776609,Inhibition of human ERG tail current expressed in HEK293 cells after 5 mins by patch clamp assay,Cn1c(SCCCN2CC3CCN(c4ccc(C#N)cc4)C3C2)nnc1-c1cnccn1,Bioorg Med Chem,CHEMBL3775097,0.25119,Yes,6.599997654
CHEMBL3776609,Inhibition of human ERG tail current expressed in HEK293 cells after 5 mins by patch clamp assay,Cn1c(SCCCN2CC3CCN(c4ccccc4OC(F)(F)F)C3C2)nnc1-c1cnccn1,Bioorg Med Chem,CHEMBL3774621,0.63096,Yes,6.199998172
CHEMBL3776609,Inhibition of human ERG tail current expressed in HEK293 cells after 5 mins by patch clamp assay,Cn1c(SCCCN2CC3CCN(c4cccc(OC(F)(F)F)c4)C3C2)nnc1-c1cnccn1,Bioorg Med Chem,CHEMBL3774895,0.12589,Yes,6.900008766
CHEMBL3776609,Inhibition of human ERG tail current expressed in HEK293 cells after 5 mins by patch clamp assay,COc1cccc(N2CCC3CN(CCCSc4nnc(-c5cnccn5)n4C)CC32)c1,Bioorg Med Chem,CHEMBL3774412,0.79433,Yes,6.099999035
CHEMBL3776609,Inhibition of human ERG tail current expressed in HEK293 cells after 5 mins by patch clamp assay,COc1ccc(N2CCC3CN(CCCSc4nnc(-c5cnccn5)n4C)CC32)cc1,Bioorg Med Chem,CHEMBL3775023,0.79433,Yes,6.099999035
CHEMBL3776609,Inhibition of human ERG tail current expressed in HEK293 cells after 5 mins by patch clamp assay,Cc1ccccc1N1CCC2CN(CCCSc3nnc(-c4cnccn4)n3C)CC21,Bioorg Med Chem,CHEMBL3774927,0.31623,Yes,6.499996932
CHEMBL3776609,Inhibition of human ERG tail current expressed in HEK293 cells after 5 mins by patch clamp assay,Cc1cccc(N2CCC3CN(CCCSc4nnc(-c5cnccn5)n4C)CC32)c1,Bioorg Med Chem,CHEMBL3775836,0.31623,Yes,6.499996932
CHEMBL3776609,Inhibition of human ERG tail current expressed in HEK293 cells after 5 mins by patch clamp assay,Cc1ccc(N2CCC3CN(CCCSc4nnc(-c5cnccn5)n4C)CC32)cc1,Bioorg Med Chem,CHEMBL3775071,0.39811,Yes,6.399996913
CHEMBL3776609,Inhibition of human ERG tail current expressed in HEK293 cells after 5 mins by patch clamp assay,Cn1c(SCCCN2CC3CCN(c4cccc(F)c4)C3C2)nnc1-c1cnccn1,Bioorg Med Chem,CHEMBL3774869,0.19953,Yes,6.699991797
CHEMBL3776609,Inhibition of human ERG tail current expressed in HEK293 cells after 5 mins by patch clamp assay,Cn1c(SCCCN2CC3CCN(c4ccc(F)cc4)C3C2)nnc1-c1cnccn1,Bioorg Med Chem,CHEMBL3774996,0.31623,Yes,6.499996932
CHEMBL3776609,Inhibition of human ERG tail current expressed in HEK293 cells after 5 mins by patch clamp assay,Cn1c(SCCCN2CC3CCN(c4ccc(C(F)(F)F)cc4)C3C2)nnc1-c1cnccn1,Bioorg Med Chem,CHEMBL3774683,0.25119,Yes,6.599997654
CHEMBL3776609,Inhibition of human ERG tail current expressed in HEK293 cells after 5 mins by patch clamp assay,Cn1c(SCCCN2CC3CCN(c4ccc(C(F)(F)F)cc4)C3C2)nnc1-c1cnccn1,Bioorg Med Chem,CHEMBL3774683,0.12589,Yes,6.900008766
CHEMBL3776609,Inhibition of human ERG tail current expressed in HEK293 cells after 5 mins by patch clamp assay,Cc1ncoc1-c1nnc(SCCCN2CC3CCN(c4ccccc4OC(F)(F)F)C3C2)n1C,Bioorg Med Chem,CHEMBL3775872,0.63096,Yes,6.199998172
CHEMBL3776609,Inhibition of human ERG tail current expressed in HEK293 cells after 5 mins by patch clamp assay,Cc1ncoc1-c1nnc(SCCCN2CC3CCN(c4cccc(C#N)c4)C3C2)n1C,Bioorg Med Chem,CHEMBL3775534,0.79433,Yes,6.099999035
CHEMBL3776609,Inhibition of human ERG tail current expressed in HEK293 cells after 5 mins by patch clamp assay,Cc1ncoc1-c1nnc(SCCCN2CC3CCN(c4cccc(F)c4)C3C2)n1C,Bioorg Med Chem,CHEMBL3775005,0.25119,Yes,6.599997654
CHEMBL3776609,Inhibition of human ERG tail current expressed in HEK293 cells after 5 mins by patch clamp assay,Cc1ncoc1-c1nnc(SCCCN2CC3CCN(c4ccc(F)cc4)C3C2)n1C,Bioorg Med Chem,CHEMBL3774588,0.79433,Yes,6.099999035
CHEMBL3776609,Inhibition of human ERG tail current expressed in HEK293 cells after 5 mins by patch clamp assay,Cc1ncoc1-c1nnc(SCCCN2CC3CCN(c4ccc(F)cc4)C3C2)n1C,Bioorg Med Chem,CHEMBL3774588,0.79433,Yes,6.099999035
CHEMBL3776609,Inhibition of human ERG tail current expressed in HEK293 cells after 5 mins by patch clamp assay,Cc1ncoc1-c1nnc(SCCCN2CC3CCN(c4ccc(C(F)(F)F)cc4F)C3C2)n1C,Bioorg Med Chem,CHEMBL3775226,0.39811,Yes,6.399996913
CHEMBL3776609,Inhibition of human ERG tail current expressed in HEK293 cells after 5 mins by patch clamp assay,Cc1ncoc1-c1nnc(SCCCN2CC3CCN(c4ccc(C(F)(F)F)cc4F)C3C2)n1C,Bioorg Med Chem,CHEMBL3775226,0.19953,Yes,6.699991797
CHEMBL3776609,Inhibition of human ERG tail current expressed in HEK293 cells after 5 mins by patch clamp assay,Cc1ncoc1-c1nnc(SCCCN2CC3CCN(c4ccc(C(F)(F)F)cc4)C3C2)n1C,Bioorg Med Chem,CHEMBL3774540,0.19953,Yes,6.699991797
CHEMBL3776609,Inhibition of human ERG tail current expressed in HEK293 cells after 5 mins by patch clamp assay,Cc1ncoc1-c1nnc(SCCCN2CC3CCN(c4ccc(C(F)(F)F)cc4)C3C2)n1C,Bioorg Med Chem,CHEMBL3774540,0.19953,Yes,6.699991797
CHEMBL3776609,Inhibition of human ERG tail current expressed in HEK293 cells after 5 mins by patch clamp assay,Cc1ncoc1-c1nnc(SCCCN2CC3CCN(c4ccc(C(F)(F)F)cc4)C3C2)n1C,Bioorg Med Chem,CHEMBL3774540,0.19953,Yes,6.699991797
CHEMBL3776609,Inhibition of human ERG tail current expressed in HEK293 cells after 5 mins by patch clamp assay,N#Cc1ccc2c(c1)CCN(CC[C@H]1CC[C@H](NC(=O)c3ccnc4ccccc34)CC1)C2,Bioorg Med Chem,CHEMBL85606,0.63096,Yes,6.199998172
CHEMBL3779605,Binding affinity to human ERG,Clc1ccc(-c2c[nH]c([C@H]3Cc4c([nH]c5ccccc45)[C@@H](C4CCOCC4)N3)n2)nc1,Bioorg Med Chem Lett,CHEMBL3774909,0.465,Yes,6.332547047
CHEMBL3779605,Binding affinity to human ERG,c1ccc2c3c([nH]c2c1)[C@@H](C1CCOCC1)N[C@@H](c1nc(-c2csc4ccccc24)c[nH]1)C3,Bioorg Med Chem Lett,CHEMBL3775284,0.087,Yes,7.060480747
CHEMBL3779605,Binding affinity to human ERG,Clc1ccc(-c2c[nH]c([C@H]3Cc4c([nH]c5ccccc45)[C@@H](C4CCOCC4)N3)n2)s1,Bioorg Med Chem Lett,CHEMBL3775435,0.522,Yes,6.282329497
CHEMBL3779605,Binding affinity to human ERG,c1ccc2c3c([nH]c2c1)[C@@H](C1CCOCC1)N[C@@H](c1nc(-c2ccsc2)c[nH]1)C3,Bioorg Med Chem Lett,CHEMBL3774626,0.146,Yes,6.835647144
CHEMBL3779605,Binding affinity to human ERG,Fc1ccc(-c2c[nH]c([C@H]3Cc4c([nH]c5ccccc45)[C@@H](C4CCOCC4)N3)n2)c(F)c1,Bioorg Med Chem Lett,CHEMBL3775050,0.634,Yes,6.197910742
CHEMBL3779605,Binding affinity to human ERG,Fc1ccc(-c2c[nH]c([C@H]3Cc4c([nH]c5ccccc45)[C@@H](C4CCOCC4)N3)n2)cc1F,Bioorg Med Chem Lett,CHEMBL3775532,0.35,Yes,6.455931956
CHEMBL3779605,Binding affinity to human ERG,O=C(O)c1cccc(-c2c[nH]c([C@H]3Cc4c([nH]c5ccccc45)[C@@H](C4CCOCC4)N3)n2)c1,Bioorg Med Chem Lett,CHEMBL3774488,0.839,Yes,6.076238039
CHEMBL3779605,Binding affinity to human ERG,c1ccc(-c2ccc(-c3c[nH]c([C@H]4Cc5c([nH]c6ccccc56)[C@@H](C5CCOCC5)N4)n3)cc2)cc1,Bioorg Med Chem Lett,CHEMBL3775414,0.017,Yes,7.769551079
CHEMBL3779605,Binding affinity to human ERG,FC(F)(F)Oc1cccc(-c2c[nH]c([C@H]3Cc4c([nH]c5ccccc45)[C@@H](C4CCOCC4)N3)n2)c1,Bioorg Med Chem Lett,CHEMBL3775456,0.058,Yes,7.236572006
CHEMBL3779605,Binding affinity to human ERG,FC(F)(F)Oc1ccc(-c2c[nH]c([C@H]3Cc4c([nH]c5ccccc45)[C@@H](C4CCOCC4)N3)n2)cc1,Bioorg Med Chem Lett,CHEMBL3775316,0.13,Yes,6.886056648
CHEMBL3779605,Binding affinity to human ERG,COc1cccc(-c2c[nH]c([C@H]3Cc4c([nH]c5ccccc45)[C@@H](C4CCOCC4)N3)n2)c1,Bioorg Med Chem Lett,CHEMBL3775031,0.247,Yes,6.607303047
CHEMBL3779605,Binding affinity to human ERG,COc1ccc(-c2c[nH]c([C@H]3Cc4c([nH]c5ccccc45)[C@@H](C4CCOCC4)N3)n2)cc1,Bioorg Med Chem Lett,CHEMBL3775282,0.069,Yes,7.161150909
CHEMBL3779605,Binding affinity to human ERG,Oc1ccc(-c2c[nH]c([C@H]3Cc4c([nH]c5ccccc45)[C@@H](C4CCOCC4)N3)n2)cc1,Bioorg Med Chem Lett,CHEMBL3775398,0.467,Yes,6.330683119
CHEMBL3779605,Binding affinity to human ERG,FC(F)(F)c1ccc(-c2c[nH]c([C@H]3Cc4c([nH]c5ccccc45)[C@@H](C4CCOCC4)N3)n2)cc1,Bioorg Med Chem Lett,CHEMBL3775793,0.158,Yes,6.801342913
CHEMBL3779605,Binding affinity to human ERG,Cc1ccc(-c2c[nH]c([C@H]3Cc4c([nH]c5ccccc45)[C@@H](C4CCOCC4)N3)n2)cc1,Bioorg Med Chem Lett,CHEMBL3774791,0.101,Yes,6.995678626
CHEMBL3779605,Binding affinity to human ERG,Clc1ccc(-c2c[nH]c([C@H]3Cc4c([nH]c5ccccc45)[C@@H](C4CCOCC4)N3)n2)cc1,Bioorg Med Chem Lett,CHEMBL3774866,0.144,Yes,6.841637508
CHEMBL3779605,Binding affinity to human ERG,Fc1ccccc1-c1c[nH]c([C@H]2Cc3c([nH]c4ccccc34)[C@@H](C3CCOCC3)N2)n1,Bioorg Med Chem Lett,CHEMBL3774495,0.495,Yes,6.305394801
CHEMBL3779605,Binding affinity to human ERG,Fc1cccc(-c2c[nH]c([C@H]3Cc4c([nH]c5ccccc45)[C@@H](C4CCOCC4)N3)n2)c1,Bioorg Med Chem Lett,CHEMBL3774817,0.258,Yes,6.588380294
CHEMBL3779605,Binding affinity to human ERG,Fc1ccc(-c2c[nH]c([C@H]3Cc4c([nH]c5ccccc45)[C@@H](C4CCOCC4)N3)n2)cc1,Bioorg Med Chem Lett,CHEMBL2204941,0.377,Yes,6.42365865
CHEMBL3779605,Binding affinity to human ERG,c1ccc2c3c([nH]c2c1)C(C1CCOCC1)NC(c1nc(C24CC5CC(CC(C5)C2)C4)c[nH]1)C3,Bioorg Med Chem Lett,CHEMBL3775851,0.506,Yes,6.295849483
CHEMBL3779605,Binding affinity to human ERG,c1ccc2c3c([nH]c2c1)C(C1CCOCC1)NC(c1nc(C2CCCCC2)c[nH]1)C3,Bioorg Med Chem Lett,CHEMBL3775580,0.136,Yes,6.866461092
CHEMBL3779605,Binding affinity to human ERG,CC1(c2nc(-c3ccccc3)c[nH]2)Cc2c([nH]c3ccccc23)C(C2CCOCC2)N1,Bioorg Med Chem Lett,CHEMBL3775729,0.53,Yes,6.27572413
CHEMBL3779605,Binding affinity to human ERG,c1ccc(-c2c[nH]c([C@H]3Cc4c([nH]c5ccccc45)[C@@H](C4CCOCC4)N3)n2)cc1,Bioorg Med Chem Lett,CHEMBL2069502,0.38,Yes,6.420216403
CHEMBL3783629,Inhibition of human ERG by QPatch assay,Cc1cc(C)n(Cc2ccc(C(=O)NCC3(c4nc(-c5ccccc5)cs4)CCOCC3)cc2)n1,Eur J Med Chem,CHEMBL3780951,44.9,No,4.347753659
CHEMBL3790041,Inhibition of human ERG,CC(C)(C)NC(=O)C1c2ccccc2C(=O)N1Cc1ccccc1-c1ccccc1,Bioorg Med Chem Lett,CHEMBL3786542,62,No,4.207608311
CHEMBL3790041,Inhibition of human ERG,CCCCNC(=O)C1c2ccccc2C(=O)N1CC(C)c1ccc(Cl)cc1,Bioorg Med Chem Lett,CHEMBL3785486,32,No,4.494850022
CHEMBL3790041,Inhibition of human ERG,Cc1c(O)ccc2c1C(=O)N(Cc1ccccc1-c1ccccc1)C2C(=O)NC(C)(C)C,Bioorg Med Chem Lett,CHEMBL3785865,46,No,4.337242168
CHEMBL3790041,Inhibition of human ERG,CC(C)(C)NC(=O)C1c2ccc(O)cc2C(=O)N1Cc1ccccc1-c1ccccc1,Bioorg Med Chem Lett,CHEMBL3787069,45,No,4.346787486
CHEMBL3790041,Inhibition of human ERG,CC(C)(C)NC(=O)C1c2ccccc2C(=O)N1Cc1ccccc1-c1ccc(F)cc1,Bioorg Med Chem Lett,CHEMBL3786303,56,No,4.251811973
CHEMBL3789028,Inhibition of human ERG by patch clamp method,COc1cc2c(cc1Nc1ncc(Cl)c(Nc3ccccc3S(=O)(=O)C(C)C)n1)CCC(N)C2(C)C,Bioorg Med Chem Lett,CHEMBL3786892,44,No,4.356547324
CHEMBL3791472,Inhibition of human ERG by IonWork assay,O=C(c1nnc(-c2ccccc2)o1)N1CCC(Oc2ccc(CN3CCC(O)C3)cc2)CC1,J Med Chem,CHEMBL3787345,31,No,4.508638306
CHEMBL3789410,Inhibition of human ERG by dofetilide binding assay,Nc1ncnc2c1c(-c1cccc(OCc3ccccc3)c1)cn2[C@H]1C[C@@H](CN2CCC2)C1,Bioorg Med Chem Lett,CHEMBL1614712,0.13,Yes,6.886056648
CHEMBL3789410,Inhibition of human ERG by dofetilide binding assay,Nc1ncnc2c1c(-c1cccc(O)c1)cn2[C@H]1C[C@@H](CN2CCC2)C1,Bioorg Med Chem Lett,CHEMBL3787112,0.42,Yes,6.37675071
CHEMBL3789676,Displacement of [3H]-dofetilide from human ERG channel expressed in HEK293 cells,Nc1ncnc2c1c(-c1cccc(OCc3ccccc3)c1)cn2[C@H]1C[C@@H](CN2CCC2)C1,Bioorg Med Chem Lett,CHEMBL1614712,0.13,Yes,6.886056648
CHEMBL3789775,Displacement of [3H]dofetilide from human ERG channel expressed in HEK293 cells after 60 mins by liquid scintillation counting method,Cc1cc(F)ccc1C1CCN(CC2Cc3ccccc3CN2)CC1,Eur J Med Chem,CHEMBL3786469,0.2,Yes,6.698970004
CHEMBL3789775,Displacement of [3H]dofetilide from human ERG channel expressed in HEK293 cells after 60 mins by liquid scintillation counting method,Cc1cc(F)ccc1C1CCN(CC2Cc3c(Cl)ccc(O)c3CN2)CC1,Eur J Med Chem,CHEMBL3785952,0.97,Yes,6.013228266
CHEMBL3789775,Displacement of [3H]dofetilide from human ERG channel expressed in HEK293 cells after 60 mins by liquid scintillation counting method,CC(=O)N1Cc2ccccc2CC1CN1CCC2(CCc3ccccc32)CC1,Eur J Med Chem,CHEMBL3787051,0.5,Yes,6.301029996
CHEMBL3789775,Displacement of [3H]dofetilide from human ERG channel expressed in HEK293 cells after 60 mins by liquid scintillation counting method,Oc1cccc2c1CNC(CN1CCC3(CCc4ccccc43)CC1)C2,Eur J Med Chem,CHEMBL3785718,0.94,Yes,6.026872146
CHEMBL3789775,Displacement of [3H]dofetilide from human ERG channel expressed in HEK293 cells after 60 mins by liquid scintillation counting method,Oc1ccc2c(c1)CC(CN1CCC3(CCc4ccccc43)CC1)NC2,Eur J Med Chem,CHEMBL3785728,0.34,Yes,6.468521083
CHEMBL3794985,Inhibition of human ERG,O=c1ccc2ccc(F)c3c2n1C[C@H]3CN1CCC(NCc2cc3c(nn2)OCCO3)CC1,Bioorg Med Chem Lett,CHEMBL3793226,238,No,3.623423043
CHEMBL3794985,Inhibition of human ERG,O=c1cnc2ccc(F)c3c2n1C[C@H]3CN1CCC(NCc2cc3c(nn2)OCCO3)CC1,Bioorg Med Chem Lett,CHEMBL3794265,42,No,4.37675071
CHEMBL3797009,Displacement of [35S]-MK499 from human ERG expressed in HEK293 cells,O=C1OCc2cc(CCN3CCN(C(=O)Cc4ccc(-n5cnnn5)cn4)CC3)ccc21,Bioorg Med Chem Lett,CHEMBL3793471,46,No,4.337242168
CHEMBL3797009,Displacement of [35S]-MK499 from human ERG expressed in HEK293 cells,Cc1c(CCN2CCN(C(=O)Cc3ccc(-n4cnnn4)cn3)CC2)ccc2c1COC2=O,Bioorg Med Chem Lett,CHEMBL3792966,33,No,4.48148606
CHEMBL3797009,Displacement of [35S]-MK499 from human ERG expressed in HEK293 cells,Cc1cc(-n2cnnn2)cnc1CC(=O)N1CCN(CCc2ccc3c(c2C)COC3=O)CC1,Bioorg Med Chem Lett,CHEMBL3793380,52,No,4.283996656
CHEMBL3797007,Inhibition of human ERG by electrophysiology analysis,Cc1cc(-n2cnnn2)cnc1CC(=O)N1CCN(CCc2ccc3c(c2C)COC3=O)CC1,Bioorg Med Chem Lett,CHEMBL3793380,52,No,4.283996656
CHEMBL3797009,Displacement of [35S]-MK499 from human ERG expressed in HEK293 cells,Cc1cc(-n2cnnn2)ncc1C(C)C(=O)N1CCN(CCc2ccc3c(c2C)COC3=O)CC1,Bioorg Med Chem Lett,CHEMBL3793717,42,No,4.37675071
CHEMBL3797009,Displacement of [35S]-MK499 from human ERG expressed in HEK293 cells,Cc1c(C(C)CN2CCN(C(=O)Cc3ccc(-n4cnnn4)nc3)CC2)ccc2c1COC2=O,Bioorg Med Chem Lett,CHEMBL3794292,49,No,4.30980392
CHEMBL3797009,Displacement of [35S]-MK499 from human ERG expressed in HEK293 cells,Cc1c(C(O)CN2CCN(C(=O)Cc3ccc(-n4cnnn4)nc3)CC2)ccc2c1COC2=O,Bioorg Med Chem Lett,CHEMBL3794233,33,No,4.48148606
CHEMBL3801063,Inhibition of wild type human ERG channel expressed in Xenopus laevis oocytes assessed as use dependent suppression of K+ current at 1 Hz equilibrated for 5 mins by two-electrode voltage clamp method,O=C(CCc1ccccc1)c1ccccc1OCC(O)CN1CCN(C(c2ccccc2)(c2ccccc2)c2ccccc2)CC1,Medchemcomm,CHEMBL3800381,47.1,No,4.326979093
CHEMBL3802897,Inhibition of human ERG,CN(C)C(=O)c1cc(CN2CCOc3c(F)cccc32)c2oc(N3CCOCC3)cc(=O)c2c1,Bioorg Med Chem Lett,CHEMBL3799831,94,No,4.026872146
CHEMBL3803792,Inhibition of human ERG assessed as reduction in channel current by automated patch-clamp electrophysiology assay,COc1ccc(CCN2CCC(Nc3nc4ccccc4n3Cc3ccc(F)cc3)CC2)cc1,Eur J Med Chem,CHEMBL296419,0.00331,Yes,8.480172006
CHEMBL3803792,Inhibition of human ERG assessed as reduction in channel current by automated patch-clamp electrophysiology assay,CNC(=O)c1cc(Oc2ccc3nc(NC(=O)c4cc(C(F)(F)F)cc(C(F)(F)F)c4)sc3c2)ccn1,Eur J Med Chem,CHEMBL3799621,48.38,No,4.315334136
CHEMBL3807655,Inhibition of human ERG expressed in CHOK1 cells assessed as inhibition of tail current after 5 mins by automated whole-cell patch clamp assay,Cc1cccc(CCN2CCC(C(=O)c3ccc(NS(C)(=O)=O)cc3)CC2)n1,Eur J Med Chem,CHEMBL327980,0.024,Yes,7.619788758
CHEMBL3807664,Inhibition of human ERG,Cc1cc2ncc3c(n2n1)CN([C@H]1CC[C@H](c2cc(F)c(F)cc2F)[C@@H](N)C1)C3,Bioorg Med Chem Lett,CHEMBL3805966,0.6,Yes,6.22184875
CHEMBL3807664,Inhibition of human ERG,N[C@H]1C[C@@H](N2Cc3cnc4nnc(C5CC5)n4c3C2)CC[C@@H]1c1cc(F)c(F)cc1F,Bioorg Med Chem Lett,CHEMBL3806041,0.6,Yes,6.22184875
CHEMBL3807664,Inhibition of human ERG,Cc1ccnc2c3c(nn12)CN([C@H]1CO[C@H](c2cc(F)ccc2F)[C@@H](N)C1)C3,Bioorg Med Chem Lett,CHEMBL3804950,97,No,4.013228266
CHEMBL3806618,Inhibition of human ERG expressed in HEK293 cells assessed as tail current at -50 mV holding potential by whole-cell patch clamp method,O=c1ccc(OCCCN2CCCCC2)nn1-c1ccc(F)c(Cl)c1,J Med Chem,CHEMBL3806153,0.98,Yes,6.008773924
CHEMBL3806884,Inhibition of human ERG after 10 mins,CNC(=O)c1cc(OCCCCN2CCC(c3noc4cc(F)ccc34)CC2)ccc1F,Bioorg Med Chem Lett,CHEMBL3805518,0.998,Yes,6.000869459
CHEMBL3807184,Inhibition of human ERG expressed in cell membranes after 4 hrs by fluorescence polarization assay,Cc1cccc(CCN2CCC(C(=O)c3ccc(NS(C)(=O)=O)cc3)CC2)n1,Bioorg Med Chem,CHEMBL327980,0.07,Yes,7.15490196
CHEMBL3807756,Displacement of [3H] dofetilide from human ERG channel expressed in HEK293 cell membranes incubated for 2 hrs by scintillation counting analysis,COc1ccc(CCN2CCC(Nc3nc4ccccc4n3Cc3ccc(F)cc3)CC2)cc1,ACS Med Chem Lett,CHEMBL296419,0.023,Yes,7.638272164
CHEMBL3807756,Displacement of [3H] dofetilide from human ERG channel expressed in HEK293 cell membranes incubated for 2 hrs by scintillation counting analysis,CC(=O)Nc1ccc2c3c(cccc13)C(=O)N(CCCCN1CCC(Nc3nc4ccccc4n3Cc3ccc(F)cc3)CC1)C2=O,ACS Med Chem Lett,CHEMBL3805335,0.182,Yes,6.739928612
CHEMBL3807756,Displacement of [3H] dofetilide from human ERG channel expressed in HEK293 cell membranes incubated for 2 hrs by scintillation counting analysis,O=[N+]([O-])c1ccc(NCCCCN2CCC(Nc3nc4ccccc4n3Cc3ccc(F)cc3)CC2)c2nonc12,ACS Med Chem Lett,CHEMBL3805898,0.025,Yes,7.602059991
CHEMBL3807756,Displacement of [3H] dofetilide from human ERG channel expressed in HEK293 cell membranes incubated for 2 hrs by scintillation counting analysis,CCN(CC)c1ccc2cc(C(=O)NCCCCN3CCC(Nc4nc5ccccc5n4Cc4ccc(F)cc4)CC3)c(=O)oc2c1,ACS Med Chem Lett,CHEMBL3804918,0.434,Yes,6.36251027
CHEMBL3806671,Inhibition of human ERG by whole-cell patch clamp assay,COc1cnc(C(=O)Nc2cc(F)c(F)c([C@]3(C)C[C@@H](c4c(C)noc4C)SC(N)=N3)c2)cn1,ACS Med Chem Lett,CHEMBL3805852,0.64,Yes,6.193820026
CHEMBL3816322,Displacement of [35S]MK499 from human ERG,CN1C(=O)Cn2c1nc1nc(N3CCC[C@@H](N)C3)n(Cc3cc(F)ccc3C#N)c1c2=O,ACS Med Chem Lett,CHEMBL3687984,40,No,4.397940009
CHEMBL3853465,Inhibition of human ERG by patch clamp method,N#Cc1ccc(Oc2ccc(S(=O)(=O)Nc3ccc(F)cn3)cc2C#N)cc1Cl,Medchemcomm,CHEMBL3683287,67,No,4.173925197
CHEMBL3855279,Inhibition of human ERG transfected in HEK293 cells assessed as reduction in tail current by patch clamp assay,N#Cc1ccc2c(c1)CCN(CC[C@H]1CC[C@H](NC(=O)c3ccnc4ccccc34)CC1)C2,J Med Chem,CHEMBL85606,0.67608,Yes,6.170001911
CHEMBL3855279,Inhibition of human ERG transfected in HEK293 cells assessed as reduction in tail current by patch clamp assay,Cc1ncoc1-c1nnc(SCCCN2CC[C@]3(C[C@H]3c3ccc(C(F)(F)F)cc3)C2)n1C,J Med Chem,CHEMBL3913607,0.19055,Yes,6.719991047
CHEMBL3855279,Inhibition of human ERG transfected in HEK293 cells assessed as reduction in tail current by patch clamp assay,Cc1ncoc1-c1nnc(SCCCN2CC[C@@]3(C[C@@H]3c3ccc(C(F)(F)F)cc3)C2)n1C,J Med Chem,CHEMBL3944642,0.37154,Yes,6.429994423
CHEMBL3855279,Inhibition of human ERG transfected in HEK293 cells assessed as reduction in tail current by patch clamp assay,Cc1ncoc1-c1nnc(SCCCN2CC[C@]3(C[C@@H]3c3ccc(C(F)(F)F)cc3)C2)n1C,J Med Chem,CHEMBL3935692,0.40738,Yes,6.390000296
CHEMBL3855279,Inhibition of human ERG transfected in HEK293 cells assessed as reduction in tail current by patch clamp assay,Cc1ncoc1-c1nnc(SCCN2CC[C@]3(C[C@H]3c3ccc(C(F)(F)F)cc3)C2)n1C,J Med Chem,CHEMBL3954568,0.31623,Yes,6.499996932
CHEMBL3855279,Inhibition of human ERG transfected in HEK293 cells assessed as reduction in tail current by patch clamp assay,Cc1ncoc1-c1nnc(SCCN2CC[C@@]3(C[C@@H]3c3ccc(C(F)(F)F)cc3)C2)n1C,J Med Chem,CHEMBL3953365,0.1349,Yes,6.86998805
CHEMBL3855279,Inhibition of human ERG transfected in HEK293 cells assessed as reduction in tail current by patch clamp assay,Cc1ncoc1-c1nnc(SCCN2CC[C@]3(C[C@@H]3c3ccc(C(F)(F)F)cc3)C2)n1C,J Med Chem,CHEMBL3936812,0.52481,Yes,6.279997898
CHEMBL3855279,Inhibition of human ERG transfected in HEK293 cells assessed as reduction in tail current by patch clamp assay,Cc1ncoc1-c1nnc(SCCCCN2CC[C@]3(C[C@@H]3c3ccc(C(F)(F)F)cc3)C2)n1C,J Med Chem,CHEMBL3908862,0.56234,Yes,6.250001023
CHEMBL3855279,Inhibition of human ERG transfected in HEK293 cells assessed as reduction in tail current by patch clamp assay,Cc1ncoc1-c1nnc(SCCCN2CC[C@@]3(C[C@@H]3c3ccccc3C(F)(F)F)C2)n1C,J Med Chem,CHEMBL3975989,0.89125,Yes,6.050000457
CHEMBL3855279,Inhibition of human ERG transfected in HEK293 cells assessed as reduction in tail current by patch clamp assay,Cc1ncoc1-c1nnc(SCCCN2CC[C@@]3(C[C@H]3c3ccc(F)cc3)C2)n1C,J Med Chem,CHEMBL3963783,0.60256,Yes,6.219999702
CHEMBL3855279,Inhibition of human ERG transfected in HEK293 cells assessed as reduction in tail current by patch clamp assay,Cc1ncoc1-c1nnc(SCCCN2CC[C@@]3(C[C@H]3c3ccc(F)cc3F)C2)n1C,J Med Chem,CHEMBL3926847,0.75858,Yes,6.119998612
CHEMBL3855279,Inhibition of human ERG transfected in HEK293 cells assessed as reduction in tail current by patch clamp assay,Cc1ncoc1-c1nnc(SCCCN2CC[C@]3(C[C@H]3c3ccc(C(F)(F)F)cc3F)C2)n1C,J Med Chem,CHEMBL3935776,0.25119,Yes,6.599997654
CHEMBL3855279,Inhibition of human ERG transfected in HEK293 cells assessed as reduction in tail current by patch clamp assay,Cc1ncoc1-c1nnc(SCCCN2CC[C@@]3(C[C@@H]3c3ccc(C(F)(F)F)cc3F)C2)n1C,J Med Chem,CHEMBL3901587,0.44668,Yes,6.350003493
CHEMBL3855279,Inhibition of human ERG transfected in HEK293 cells assessed as reduction in tail current by patch clamp assay,Cc1ncoc1-c1nnc(SCCCN2CC[C@]3(C[C@@H]3c3ccc(C(F)(F)F)cc3F)C2)n1C,J Med Chem,CHEMBL3927895,0.69183,Yes,6.160000609
CHEMBL3855279,Inhibition of human ERG transfected in HEK293 cells assessed as reduction in tail current by patch clamp assay,Cc1ncoc1-c1nnc(SCCCN2CC[C@@]3(C[C@H]3c3ccc(C(F)(F)F)cc3F)C2)n1C,J Med Chem,CHEMBL3955505,0.52481,Yes,6.279997898
CHEMBL3855279,Inhibition of human ERG transfected in HEK293 cells assessed as reduction in tail current by patch clamp assay,Cc1ncoc1-c1nnc(SCCCN2CC[C@]3(C[C@@H]3c3cc(Cl)cc(Cl)c3)C2)n1C,J Med Chem,CHEMBL3899336,0.26303,Yes,6.579994715
CHEMBL3855279,Inhibition of human ERG transfected in HEK293 cells assessed as reduction in tail current by patch clamp assay,Cc1ncsc1-c1nnc(SCCCN2CC[C@]3(C[C@@H]3c3ccc(C(F)(F)F)cc3)C2)n1C,J Med Chem,CHEMBL3923578,0.79433,Yes,6.099999035
CHEMBL3855279,Inhibition of human ERG transfected in HEK293 cells assessed as reduction in tail current by patch clamp assay,Cn1c(SCCCN2CC[C@]3(C[C@@H]3c3ccc(C(F)(F)F)cc3)C2)nnc1-c1nccs1,J Med Chem,CHEMBL3914556,0.44668,Yes,6.350003493
CHEMBL3855279,Inhibition of human ERG transfected in HEK293 cells assessed as reduction in tail current by patch clamp assay,Cn1c(SCCCN2CC[C@]3(C[C@H]3c3ccc(C(F)(F)F)cc3)C2)nnc1-c1csnn1,J Med Chem,CHEMBL3984387,0.1122,Yes,6.950007143
CHEMBL3855279,Inhibition of human ERG transfected in HEK293 cells assessed as reduction in tail current by patch clamp assay,Cn1c(SCCCN2CC[C@]3(C[C@@H]3c3ccc(C(F)(F)F)cc3)C2)nnc1-c1ccoc1,J Med Chem,CHEMBL3985419,0.15136,Yes,6.819988881
CHEMBL3855279,Inhibition of human ERG transfected in HEK293 cells assessed as reduction in tail current by patch clamp assay,Cn1cc(-c2nnc(SCCCN3CC[C@]4(C[C@@H]4c4ccc(C(F)(F)F)cc4)C3)n2C)cn1,J Med Chem,CHEMBL3956758,0.46774,Yes,6.329995489
CHEMBL3855279,Inhibition of human ERG transfected in HEK293 cells assessed as reduction in tail current by patch clamp assay,Cn1nccc1-c1nnc(SCCCN2CC[C@]3(C[C@@H]3c3ccc(C(F)(F)F)cc3)C2)n1C,J Med Chem,CHEMBL3908174,0.6166,Yes,6.20999648
CHEMBL3855279,Inhibition of human ERG transfected in HEK293 cells assessed as reduction in tail current by patch clamp assay,Cc1cc(-c2nnc(SCCCN3CC[C@]4(C[C@@H]4c4ccc(C(F)(F)F)cc4)C3)n2C)on1,J Med Chem,CHEMBL3978613,0.20417,Yes,6.690008071
CHEMBL3855279,Inhibition of human ERG transfected in HEK293 cells assessed as reduction in tail current by patch clamp assay,Cn1c(SCCCN2CC[C@]3(C[C@@H]3c3ccc(C(F)(F)F)cc3)C2)nnc1-c1ccc(C(N)=O)cc1,J Med Chem,CHEMBL3899125,0.81283,Yes,6.090000276
CHEMBL3855279,Inhibition of human ERG transfected in HEK293 cells assessed as reduction in tail current by patch clamp assay,Cn1c(SCCCN2CC[C@]3(C[C@@H]3c3ccc(C(F)(F)F)cc3)C2)nnc1-c1ccc(S(N)(=O)=O)cc1,J Med Chem,CHEMBL3959240,0.22387,Yes,6.650004101
CHEMBL3855279,Inhibition of human ERG transfected in HEK293 cells assessed as reduction in tail current by patch clamp assay,Cn1c(SCCCN2CC[C@]3(C[C@@H]3c3ccc(C(F)(F)F)cc3)C2)nnc1-c1ccc(-c2ncco2)cc1,J Med Chem,CHEMBL3941818,0.15136,Yes,6.819988881
CHEMBL3855279,Inhibition of human ERG transfected in HEK293 cells assessed as reduction in tail current by patch clamp assay,Cn1c(SCCCN2CC[C@]3(C[C@@H]3c3ccc(C(F)(F)F)cc3)C2)nnc1-c1cccc(-c2ncco2)c1,J Med Chem,CHEMBL3920167,0.12023,Yes,6.919987153
CHEMBL3855279,Inhibition of human ERG transfected in HEK293 cells assessed as reduction in tail current by patch clamp assay,Cn1c(SCCCN2CC[C@]3(C[C@@H]3c3ccc(C(F)(F)F)cc3)C2)nnc1-c1ccccn1,J Med Chem,CHEMBL3946901,0.2,Yes,6.698970004
CHEMBL3855279,Inhibition of human ERG transfected in HEK293 cells assessed as reduction in tail current by patch clamp assay,Cn1c(SCCCN2CC[C@]3(C[C@H]3c3ccc(C(F)(F)F)cc3)C2)nnc1-c1ccncc1,J Med Chem,CHEMBL3947961,0.22387,Yes,6.650004101
CHEMBL3855279,Inhibition of human ERG transfected in HEK293 cells assessed as reduction in tail current by patch clamp assay,Cn1c(SCCCN2CC[C@]3(C[C@@H]3c3ccc(C(F)(F)F)cc3)C2)nnc1-c1ccncc1,J Med Chem,CHEMBL3929083,0.29512,Yes,6.530001358
CHEMBL3855279,Inhibition of human ERG transfected in HEK293 cells assessed as reduction in tail current by patch clamp assay,Cn1c(SCCCN2CC[C@]3(C[C@@H]3c3ccc(C(F)(F)F)cc3)C2)nnc1-c1ccccn1,J Med Chem,CHEMBL3946901,0.20893,Yes,6.679999196
CHEMBL3855279,Inhibition of human ERG transfected in HEK293 cells assessed as reduction in tail current by patch clamp assay,Cn1c(SCCCN2CC[C@]3(C[C@@H]3c3ccc(C(F)(F)F)cc3)C2)nnc1-c1cnccn1,J Med Chem,CHEMBL3955608,0.25704,Yes,6.589999287
CHEMBL3855279,Inhibition of human ERG transfected in HEK293 cells assessed as reduction in tail current by patch clamp assay,Cn1c(SCCCN2CC[C@]3(C[C@@H]3c3ccc(C(F)(F)F)cc3)C2)nnc1-c1ccncn1,J Med Chem,CHEMBL3958309,0.14454,Yes,6.84001195
CHEMBL3855279,Inhibition of human ERG transfected in HEK293 cells assessed as reduction in tail current by patch clamp assay,Cn1c(SCCCN2CC[C@]3(C[C@@H]3c3ccc(C(F)(F)F)cc3F)C2)nnc1-c1cccnc1,J Med Chem,CHEMBL3949662,0.93325,Yes,6.030002001
CHEMBL3855279,Inhibition of human ERG transfected in HEK293 cells assessed as reduction in tail current by patch clamp assay,COc1ncccc1-c1nnc(SCCCN2CC[C@]3(C[C@@H]3c3ccc(C(F)(F)F)cc3)C2)n1C,J Med Chem,CHEMBL3958949,0.60256,Yes,6.219999702
CHEMBL3855279,Inhibition of human ERG transfected in HEK293 cells assessed as reduction in tail current by patch clamp assay,Cn1c(SCCCN2CC[C@]3(C[C@@H]3c3ccc(C(F)(F)F)cc3)C2)nnc1-c1ccc(C(N)=O)nc1,J Med Chem,CHEMBL3950254,0.66069,Yes,6.180002266
CHEMBL3855279,Inhibition of human ERG transfected in HEK293 cells assessed as reduction in tail current by patch clamp assay,Cc1ccc(-c2nnc(SCCCN3CC[C@]4(C[C@@H]4c4ccc(C(F)(F)F)cc4)C3)n2C)c(C)n1,J Med Chem,CHEMBL3913542,0.93325,Yes,6.030002001
CHEMBL3855279,Inhibition of human ERG transfected in HEK293 cells assessed as reduction in tail current by patch clamp assay,Cn1c(SCCCN2CC[C@]3(C[C@@H]3c3ccc(C(F)(F)F)cc3)C2)nnc1C1CCCCC1,J Med Chem,CHEMBL3958201,0.29512,Yes,6.530001358
CHEMBL3858245,Inhibition of human ERG,COc1c(Nc2ncc(Cl)c(Nc3ccccc3S(=O)(=O)N(C)C)n2)ccc2c1CCCC(N1CCN(CCO)CC1)C2,J Med Chem,CHEMBL3918616,0.24,Yes,6.619788758
CHEMBL3859635,Inhibition of human ERG,CCn1c(=O)oc2ccc(-c3ccc(C[C@@H](C#N)NC(=O)[C@@H]4CNCCCO4)cc3)cc21,J Med Chem,CHEMBL3980602,31,No,4.508638306
CHEMBL3859699,Inhibition of human ERG,CN(CCOc1ccc(NS(C)(=O)=O)cc1)CCc1ccc(NS(C)(=O)=O)cc1,J Med Chem,CHEMBL473,0.2,Yes,6.698970004
CHEMBL3865242,Displacement of [3H]-dofetilide from human ERG expressed in HEK293 cell membranes after 90 mins by scintillation counting,Fc1ccc(-c2cnn(Cc3cc[nH]n3)c2)cc1OC(F)F,ACS Med Chem Lett,CHEMBL3954438,135,No,3.869666232
CHEMBL3865242,Displacement of [3H]-dofetilide from human ERG expressed in HEK293 cell membranes after 90 mins by scintillation counting,CCc1[nH]ncc1Cn1cc(-c2ccc(Cl)c(OC(F)F)c2)cn1,ACS Med Chem Lett,CHEMBL3983077,35,No,4.455931956
CHEMBL3865242,Displacement of [3H]-dofetilide from human ERG expressed in HEK293 cell membranes after 90 mins by scintillation counting,FC(F)Oc1cc(-c2cnn(Cc3cn[nH]c3)c2)ccc1Cl,ACS Med Chem Lett,CHEMBL3927856,52.6,No,4.279014256
CHEMBL3865242,Displacement of [3H]-dofetilide from human ERG expressed in HEK293 cell membranes after 90 mins by scintillation counting,Cn1cc(Cn2cc(-c3ccc(Cl)c(OC(F)F)c3)cn2)cn1,ACS Med Chem Lett,CHEMBL3936854,52.4,No,4.280668713
CHEMBL3868266,Inhibition of human ERG,Cc1cc(-c2cc(OC(F)(F)F)ccc2Cl)cc(C)c1OCCCC(=O)O,Bioorg Med Chem Lett,CHEMBL3909872,54.57,No,4.263046046
CHEMBL3869648,Displacement of 35S-MK499 from human ERG expressed in HEK293 cell membranes,Cc1c([C@H]2CN3CCN(C(=O)Cc4ccc(-n5cnnn5)nc4)C[C@@H]3CO2)ccc2c1COC2=O,Bioorg Med Chem Lett,CHEMBL3928846,53.4,No,4.272458743
CHEMBL3869648,Displacement of 35S-MK499 from human ERG expressed in HEK293 cell membranes,Cc1c([C@@H]2CN3CCN(C(=O)Cc4ccc(-n5cnnn5)nc4)C[C@@H]3CO2)ccc2c1COC2=O,Bioorg Med Chem Lett,CHEMBL3922156,59.4,No,4.226213555
CHEMBL3869650,Inhibition of human ERG by electrophysiology method,Cc1c([C@H]2CN3CCN(C(=O)Cc4ccc(-n5cnnn5)nc4)C[C@H]3CO2)ccc2c1COC2=O,Bioorg Med Chem Lett,CHEMBL3900159,56.5,No,4.247951552
CHEMBL3869650,Inhibition of human ERG by electrophysiology method,Cc1c([C@@H]2CN3CCN(C(=O)Cc4ccc(-n5cnnn5)nc4)C[C@@H]3CO2)ccc2c1COC2=O,Bioorg Med Chem Lett,CHEMBL3922156,74.9,No,4.125518182
CHEMBL3869650,Inhibition of human ERG by electrophysiology method,O=C1OCCc2cc([C@@H]3CN4CCN(C(=O)Cc5ccc(-n6cnnn6)nc5)C[C@H]4CO3)ccc21,Bioorg Med Chem Lett,CHEMBL3889781,75.9,No,4.119758224
CHEMBL3869650,Inhibition of human ERG by electrophysiology method,O=C1OCCc2cc([C@H]3CN4CCN(C(=O)Cc5ccc(-n6cnnn6)nc5)C[C@@H]4CO3)ccc21,Bioorg Med Chem Lett,CHEMBL3942711,41.5,No,4.381951903
CHEMBL3869650,Inhibition of human ERG by electrophysiology method,Cc1c([C@H]2CN3CCN(C(=O)Cc4ccc(-n5cnnn5)nn4)C[C@H]3CO2)ccc(F)c1C#N,Bioorg Med Chem Lett,CHEMBL3900985,33.7,No,4.472370099
CHEMBL3870967,Displacement of [3H]-dofetilide from human ERG expressed in CHOK1 cell membranes incubated for 4 hrs in dark by luminescent assay,O=c1c2ccccc2c(Cc2ccc(Cl)cc2)nn1C[C@H]1CCCN1CCCCc1ccc(OCCCN2CCCCCC2)cc1,Bioorg Med Chem Lett,CHEMBL1767164,0.05012,Yes,7.299988938
CHEMBL3870967,Displacement of [3H]-dofetilide from human ERG expressed in CHOK1 cell membranes incubated for 4 hrs in dark by luminescent assay,CN1CCCC(n2nc(Cc3ccc(Cl)cc3)c3ccccc3c2=O)CC1,Bioorg Med Chem Lett,CHEMBL639,0.1,Yes,7
CHEMBL3870967,Displacement of [3H]-dofetilide from human ERG expressed in CHOK1 cell membranes incubated for 4 hrs in dark by luminescent assay,O=C(O)c1cc(N2CCN(CCc3ccc(OCCCN4CCCCCC4)cc3)CC2)c2ncccc2c1,Bioorg Med Chem Lett,CHEMBL3925332,39.81072,No,4.399999968
CHEMBL3870967,Displacement of [3H]-dofetilide from human ERG expressed in CHOK1 cell membranes incubated for 4 hrs in dark by luminescent assay,O=C(O)c1ccc2cccnc2c1N1CCN(CCc2ccc(OCCCN3CCCCCC3)cc2)CC1,Bioorg Med Chem Lett,CHEMBL3925977,31.62278,No,4.499999953
CHEMBL3870967,Displacement of [3H]-dofetilide from human ERG expressed in CHOK1 cell membranes incubated for 4 hrs in dark by luminescent assay,O=C(O)CCc1cnc2c(N3CCN(CCc4ccc(OCCCN5CCCCCC5)cc4)CC3)cccc2c1,Bioorg Med Chem Lett,CHEMBL3907368,31.62278,No,4.499999953
CHEMBL3870967,Displacement of [3H]-dofetilide from human ERG expressed in CHOK1 cell membranes incubated for 4 hrs in dark by luminescent assay,CCc1cc(N2CCN(CCc3ccc(OCCCN4CCCCCC4)cc3)CC2)c2nc(CCC(=O)O)ccc2c1,Bioorg Med Chem Lett,CHEMBL3926412,50.11872,No,4.300000029
CHEMBL3871742,Displacement of [3H]-dofetilide from human ERG expressed in HEK293 cell membranes,Cl.N=C(N)N/N=C/c1ccc(-c2ccc(/C=N/Nc3ccccc3Br)cc2)cc1,Bioorg Med Chem,CHEMBL3941777,0.44,Yes,6.356547324
CHEMBL3876586,Inhibition of human ERG by patch clamp method,FC(F)(F)c1c(OC[C@H]2C[C@@H]2c2ccc(Cl)cc2)ccn2c(CC3CC3)nnc12,Bioorg Med Chem,CHEMBL3885379,0.38,Yes,6.420216403
CHEMBL3878769,Inhibition of human ERG expressed in CHOK1 cells by automated patch clamp method,COc1ccc(OC)c(Cc2nc3ccccc3n2CC(=O)Nc2cc(C(C)(C)C)cc(C(C)(C)C)c2)c1,Eur J Med Chem,CHEMBL3899686,0.02,Yes,7.698970004
CHEMBL3880277,Inhibition of human ERG expressed in HEK293 cells assessed as decrease in tail current amplitude by whole cell patch clamp method,COc1ccc(-c2cc(=O)c3c(O)cc(O)cc3o2)cc1,,CHEMBL243664,32.4,No,4.48945499
CHEMBL3880277,Inhibition of human ERG expressed in HEK293 cells assessed as decrease in tail current amplitude by whole cell patch clamp method,COc1ccc(-c2cc(=O)c3cc(C)ccc3o2)cc1,,CHEMBL2442379,57.9,No,4.237321436
CHEMBL3880655,Inhibition of human ERG expressed in HEK293 cells assessed as reduction in outward tail current after 5 mins at -80 mV holding potential by patch clamp assay,Cc1cccc(CCN2CCC(C(=O)c3ccc(NS(C)(=O)=O)cc3)CC2)n1.Cl.Cl,,CHEMBL536480,0.5,Yes,6.301029996
CHEMBL3880655,Inhibition of human ERG expressed in HEK293 cells assessed as reduction in outward tail current after 5 mins at -80 mV holding potential by patch clamp assay,COc1ccc2c(c1)CN(C(=O)CCN1CCC(Cc3ccccc3)CC1)CCS2.Cl,,CHEMBL2440857,0.463,Yes,6.334419009
CHEMBL3706049,"Potassium Channel Assay: Drugs belonging to different classes have been shown to be associated with QT prolongation and in some cases serious ventricular arrhythmias. The most common mechanism for these adverse events is the inhibition of one or more cardiac potassium channels, in particular hERG. This current is important for cardiac myocyte repolarization and is a common target for drugs that prolong the QT interval. Test articles in this study were therefore characterized to determine their ability to inhibit the hERG channel. Ion channel activity was measured using a stably transfected Chinese Hamster Ovary (CHO) cell line expressing the hERG mRNA. The pharmacology of this cloned channel expressed in the CHO cell line is very similar to that observed in native tissue.",Cc1cc2nc(/C=C/C3CCCN3C)n(Cc3ccc(Cl)cc3)c2cc1C,,CHEMBL3696118,0.98,Yes,6.008773924
CHEMBL3706049,"Potassium Channel Assay: Drugs belonging to different classes have been shown to be associated with QT prolongation and in some cases serious ventricular arrhythmias. The most common mechanism for these adverse events is the inhibition of one or more cardiac potassium channels, in particular hERG. This current is important for cardiac myocyte repolarization and is a common target for drugs that prolong the QT interval. Test articles in this study were therefore characterized to determine their ability to inhibit the hERG channel. Ion channel activity was measured using a stably transfected Chinese Hamster Ovary (CHO) cell line expressing the hERG mRNA. The pharmacology of this cloned channel expressed in the CHO cell line is very similar to that observed in native tissue.",Cc1cc2nc(CC3CCNC(C)C3)n(Cc3ccc(Cl)cc3)c2cc1C,,CHEMBL3699563,0.58,Yes,6.236572006
CHEMBL3706049,"Potassium Channel Assay: Drugs belonging to different classes have been shown to be associated with QT prolongation and in some cases serious ventricular arrhythmias. The most common mechanism for these adverse events is the inhibition of one or more cardiac potassium channels, in particular hERG. This current is important for cardiac myocyte repolarization and is a common target for drugs that prolong the QT interval. Test articles in this study were therefore characterized to determine their ability to inhibit the hERG channel. Ion channel activity was measured using a stably transfected Chinese Hamster Ovary (CHO) cell line expressing the hERG mRNA. The pharmacology of this cloned channel expressed in the CHO cell line is very similar to that observed in native tissue.",Cc1cc2nc(CC3CCCNC3)n(Cc3ccc(Cl)cc3)c2cc1C,,CHEMBL3699565,0.49,Yes,6.30980392
CHEMBL3706049,"Potassium Channel Assay: Drugs belonging to different classes have been shown to be associated with QT prolongation and in some cases serious ventricular arrhythmias. The most common mechanism for these adverse events is the inhibition of one or more cardiac potassium channels, in particular hERG. This current is important for cardiac myocyte repolarization and is a common target for drugs that prolong the QT interval. Test articles in this study were therefore characterized to determine their ability to inhibit the hERG channel. Ion channel activity was measured using a stably transfected Chinese Hamster Ovary (CHO) cell line expressing the hERG mRNA. The pharmacology of this cloned channel expressed in the CHO cell line is very similar to that observed in native tissue.",Cc1cc2nc(CCC3CCCN3C)n(Cc3ccc(Cl)cc3)c2cc1C,,CHEMBL3699567,0.26,Yes,6.585026652
CHEMBL3706049,"Potassium Channel Assay: Drugs belonging to different classes have been shown to be associated with QT prolongation and in some cases serious ventricular arrhythmias. The most common mechanism for these adverse events is the inhibition of one or more cardiac potassium channels, in particular hERG. This current is important for cardiac myocyte repolarization and is a common target for drugs that prolong the QT interval. Test articles in this study were therefore characterized to determine their ability to inhibit the hERG channel. Ion channel activity was measured using a stably transfected Chinese Hamster Ovary (CHO) cell line expressing the hERG mRNA. The pharmacology of this cloned channel expressed in the CHO cell line is very similar to that observed in native tissue.",Cc1ccc2nc(CN3CCCC3)n(Cc3ccc(Cl)cc3)c2c1,,CHEMBL3699580,0.65,Yes,6.187086643
CHEMBL3887163,"hERG Patch Clamp Assay: All testing was carried out in CHO cells transfected with the hERG gene purchased from Millipore (PrecisION hERG-CHO Recombinant Cell Line CYL3038). The cell line was grown in DMEM/F-12, GlutaMAX with 10% fetal bovine serum, 1% Penicillin-Streptomycin, 1% Geneticin and 1% of 1M HEPES buffer solution, and maintained at approximately 37 °C. in a humidified atmosphere containing 5% carbon dioxide. The cells were passaged every 3-5 days based on confluency. On the day of the experiment, 50%-80% confluent cells were harvested from a 175 cm2 culture flask using Detachin. After 10 minutes of exposure to Detachin at 37 °C., the cells were centrifuged for 1 minute at 1000 RPM. The supernatant was removed and the cell pellet was reconstituted in 5-8 mL of serum free media with 2.5% of 1M HEPES, placed on the Qstirrer, and allowed to recover. After a 30 minute recovery period, experiments were initiated.",NC1=N[C@@]2(c3cc(NC(=O)c4ccc(OC(F)F)cn4)ccc3F)COCC[C@H]2CS1,,CHEMBL3973534,0.5,Yes,6.301029996
CHEMBL3887163,"hERG Patch Clamp Assay: All testing was carried out in CHO cells transfected with the hERG gene purchased from Millipore (PrecisION hERG-CHO Recombinant Cell Line CYL3038). The cell line was grown in DMEM/F-12, GlutaMAX with 10% fetal bovine serum, 1% Penicillin-Streptomycin, 1% Geneticin and 1% of 1M HEPES buffer solution, and maintained at approximately 37 °C. in a humidified atmosphere containing 5% carbon dioxide. The cells were passaged every 3-5 days based on confluency. On the day of the experiment, 50%-80% confluent cells were harvested from a 175 cm2 culture flask using Detachin. After 10 minutes of exposure to Detachin at 37 °C., the cells were centrifuged for 1 minute at 1000 RPM. The supernatant was removed and the cell pellet was reconstituted in 5-8 mL of serum free media with 2.5% of 1M HEPES, placed on the Qstirrer, and allowed to recover. After a 30 minute recovery period, experiments were initiated.",C[C@H]1C[C@H]2CSC(N)=N[C@@]2(c2cc(NC(=O)c3ccc(Cl)cn3)ccc2F)CO1,,CHEMBL3983509,0.2,Yes,6.698970004
CHEMBL3887163,"hERG Patch Clamp Assay: All testing was carried out in CHO cells transfected with the hERG gene purchased from Millipore (PrecisION hERG-CHO Recombinant Cell Line CYL3038). The cell line was grown in DMEM/F-12, GlutaMAX with 10% fetal bovine serum, 1% Penicillin-Streptomycin, 1% Geneticin and 1% of 1M HEPES buffer solution, and maintained at approximately 37 °C. in a humidified atmosphere containing 5% carbon dioxide. The cells were passaged every 3-5 days based on confluency. On the day of the experiment, 50%-80% confluent cells were harvested from a 175 cm2 culture flask using Detachin. After 10 minutes of exposure to Detachin at 37 °C., the cells were centrifuged for 1 minute at 1000 RPM. The supernatant was removed and the cell pellet was reconstituted in 5-8 mL of serum free media with 2.5% of 1M HEPES, placed on the Qstirrer, and allowed to recover. After a 30 minute recovery period, experiments were initiated.",C[C@H]1C[C@H]2CSC(N)=N[C@@]2(c2nc(NC(=O)c3ccc(OC(F)F)cn3)ccc2F)CO1,,CHEMBL3942279,0.4,Yes,6.397940009
CHEMBL3888930,"Inhibition Assay: The hERG inhibition study aims at quantifying the in vitro effects of compounds of the invention on the potassium-selective IKr current generated in normoxic conditions in stably transfected HEK 293 cells with the human ether-a-go-go-related gene (hERG). Whole-cell currents (acquisition by manual patch-clamp) elicited during a voltage pulse were recorded in baseline conditions and following application of tested compounds (5 minutes of exposure). The concentrations of tested compounds (0.3 μM; 3 μM; 10 μM; 30 μM) reflect a range believed to exceed the concentrations at expected efficacy doses in preclinical models. The pulses protocol applied is described as follow: the holding potential (every 3 seconds) was stepped from −80 mV to a maximum value of +40 mV, starting with −40 mV, in eight increments of +10 mV, for a period of 1 second. The membrane potential was then returned to −55 mV, after each of these incremented steps, for 1 second and finally repolarized to −80 mV for 1 second.",Cc1nsc(-c2nnc3n2CCN(C(=O)c2ccc(Cl)c(Cl)c2)[C@@H]3C)n1,,CHEMBL4108583,42,No,4.37675071
CHEMBL3888930,"Inhibition Assay: The hERG inhibition study aims at quantifying the in vitro effects of compounds of the invention on the potassium-selective IKr current generated in normoxic conditions in stably transfected HEK 293 cells with the human ether-a-go-go-related gene (hERG). Whole-cell currents (acquisition by manual patch-clamp) elicited during a voltage pulse were recorded in baseline conditions and following application of tested compounds (5 minutes of exposure). The concentrations of tested compounds (0.3 μM; 3 μM; 10 μM; 30 μM) reflect a range believed to exceed the concentrations at expected efficacy doses in preclinical models. The pulses protocol applied is described as follow: the holding potential (every 3 seconds) was stepped from −80 mV to a maximum value of +40 mV, starting with −40 mV, in eight increments of +10 mV, for a period of 1 second. The membrane potential was then returned to −55 mV, after each of these incremented steps, for 1 second and finally repolarized to −80 mV for 1 second.",CCc1nsc(-c2nnc3n2CCN(C(=O)c2ccc(F)cc2)[C@@H]3C)n1,,CHEMBL4113741,32,No,4.494850022
CHEMBL3888930,"Inhibition Assay: The hERG inhibition study aims at quantifying the in vitro effects of compounds of the invention on the potassium-selective IKr current generated in normoxic conditions in stably transfected HEK 293 cells with the human ether-a-go-go-related gene (hERG). Whole-cell currents (acquisition by manual patch-clamp) elicited during a voltage pulse were recorded in baseline conditions and following application of tested compounds (5 minutes of exposure). The concentrations of tested compounds (0.3 μM; 3 μM; 10 μM; 30 μM) reflect a range believed to exceed the concentrations at expected efficacy doses in preclinical models. The pulses protocol applied is described as follow: the holding potential (every 3 seconds) was stepped from −80 mV to a maximum value of +40 mV, starting with −40 mV, in eight increments of +10 mV, for a period of 1 second. The membrane potential was then returned to −55 mV, after each of these incremented steps, for 1 second and finally repolarized to −80 mV for 1 second.",Cc1nsc(-c2nnc3n2CCN(C(=O)c2ccc(Cl)cc2)[C@@H]3C)n1,,CHEMBL3608687,66,No,4.180456064
CHEMBL3888930,"Inhibition Assay: The hERG inhibition study aims at quantifying the in vitro effects of compounds of the invention on the potassium-selective IKr current generated in normoxic conditions in stably transfected HEK 293 cells with the human ether-a-go-go-related gene (hERG). Whole-cell currents (acquisition by manual patch-clamp) elicited during a voltage pulse were recorded in baseline conditions and following application of tested compounds (5 minutes of exposure). The concentrations of tested compounds (0.3 μM; 3 μM; 10 μM; 30 μM) reflect a range believed to exceed the concentrations at expected efficacy doses in preclinical models. The pulses protocol applied is described as follow: the holding potential (every 3 seconds) was stepped from −80 mV to a maximum value of +40 mV, starting with −40 mV, in eight increments of +10 mV, for a period of 1 second. The membrane potential was then returned to −55 mV, after each of these incremented steps, for 1 second and finally repolarized to −80 mV for 1 second.",Cc1nsc(-c2nnc3n2CCN(C(=O)c2ccc(Cl)c(F)c2)[C@@H]3C)n1,,CHEMBL4106866,70,No,4.15490196
CHEMBL3888930,"Inhibition Assay: The hERG inhibition study aims at quantifying the in vitro effects of compounds of the invention on the potassium-selective IKr current generated in normoxic conditions in stably transfected HEK 293 cells with the human ether-a-go-go-related gene (hERG). Whole-cell currents (acquisition by manual patch-clamp) elicited during a voltage pulse were recorded in baseline conditions and following application of tested compounds (5 minutes of exposure). The concentrations of tested compounds (0.3 μM; 3 μM; 10 μM; 30 μM) reflect a range believed to exceed the concentrations at expected efficacy doses in preclinical models. The pulses protocol applied is described as follow: the holding potential (every 3 seconds) was stepped from −80 mV to a maximum value of +40 mV, starting with −40 mV, in eight increments of +10 mV, for a period of 1 second. The membrane potential was then returned to −55 mV, after each of these incremented steps, for 1 second and finally repolarized to −80 mV for 1 second.",Cc1nsc(-c2nnc3n2CCN(C(=O)c2ccc(F)cc2)[C@@H]3C)n1,,CHEMBL3608680,70,No,4.15490196
CHEMBL3888930,"Inhibition Assay: The hERG inhibition study aims at quantifying the in vitro effects of compounds of the invention on the potassium-selective IKr current generated in normoxic conditions in stably transfected HEK 293 cells with the human ether-a-go-go-related gene (hERG). Whole-cell currents (acquisition by manual patch-clamp) elicited during a voltage pulse were recorded in baseline conditions and following application of tested compounds (5 minutes of exposure). The concentrations of tested compounds (0.3 μM; 3 μM; 10 μM; 30 μM) reflect a range believed to exceed the concentrations at expected efficacy doses in preclinical models. The pulses protocol applied is described as follow: the holding potential (every 3 seconds) was stepped from −80 mV to a maximum value of +40 mV, starting with −40 mV, in eight increments of +10 mV, for a period of 1 second. The membrane potential was then returned to −55 mV, after each of these incremented steps, for 1 second and finally repolarized to −80 mV for 1 second.",Cc1nsc(-c2nnc3n2CCN(C(=O)c2ccc(F)c(Cl)c2)[C@@H]3C)n1,,CHEMBL4114280,45,No,4.346787486
CHEMBL3888930,"Inhibition Assay: The hERG inhibition study aims at quantifying the in vitro effects of compounds of the invention on the potassium-selective IKr current generated in normoxic conditions in stably transfected HEK 293 cells with the human ether-a-go-go-related gene (hERG). Whole-cell currents (acquisition by manual patch-clamp) elicited during a voltage pulse were recorded in baseline conditions and following application of tested compounds (5 minutes of exposure). The concentrations of tested compounds (0.3 μM; 3 μM; 10 μM; 30 μM) reflect a range believed to exceed the concentrations at expected efficacy doses in preclinical models. The pulses protocol applied is described as follow: the holding potential (every 3 seconds) was stepped from −80 mV to a maximum value of +40 mV, starting with −40 mV, in eight increments of +10 mV, for a period of 1 second. The membrane potential was then returned to −55 mV, after each of these incremented steps, for 1 second and finally repolarized to −80 mV for 1 second.",Cc1nsc(-c2nnc3n2CCN(C(=O)c2cc(F)c(F)c(F)c2)[C@@H]3C)n1,,CHEMBL4115594,70,No,4.15490196
CHEMBL3888930,"Inhibition Assay: The hERG inhibition study aims at quantifying the in vitro effects of compounds of the invention on the potassium-selective IKr current generated in normoxic conditions in stably transfected HEK 293 cells with the human ether-a-go-go-related gene (hERG). Whole-cell currents (acquisition by manual patch-clamp) elicited during a voltage pulse were recorded in baseline conditions and following application of tested compounds (5 minutes of exposure). The concentrations of tested compounds (0.3 μM; 3 μM; 10 μM; 30 μM) reflect a range believed to exceed the concentrations at expected efficacy doses in preclinical models. The pulses protocol applied is described as follow: the holding potential (every 3 seconds) was stepped from −80 mV to a maximum value of +40 mV, starting with −40 mV, in eight increments of +10 mV, for a period of 1 second. The membrane potential was then returned to −55 mV, after each of these incremented steps, for 1 second and finally repolarized to −80 mV for 1 second.",Cc1nsc(-c2nnc3n2CCN(C(=O)c2ccc(F)c(F)c2F)[C@@H]3C)n1,,CHEMBL4115295,70,No,4.15490196
CHEMBL3888930,"Inhibition Assay: The hERG inhibition study aims at quantifying the in vitro effects of compounds of the invention on the potassium-selective IKr current generated in normoxic conditions in stably transfected HEK 293 cells with the human ether-a-go-go-related gene (hERG). Whole-cell currents (acquisition by manual patch-clamp) elicited during a voltage pulse were recorded in baseline conditions and following application of tested compounds (5 minutes of exposure). The concentrations of tested compounds (0.3 μM; 3 μM; 10 μM; 30 μM) reflect a range believed to exceed the concentrations at expected efficacy doses in preclinical models. The pulses protocol applied is described as follow: the holding potential (every 3 seconds) was stepped from −80 mV to a maximum value of +40 mV, starting with −40 mV, in eight increments of +10 mV, for a period of 1 second. The membrane potential was then returned to −55 mV, after each of these incremented steps, for 1 second and finally repolarized to −80 mV for 1 second.",Cc1nsc(-c2nnc3n2CCN(C(=O)c2ccc(F)c(F)c2)[C@@H]3C)n1,,CHEMBL4112037,70,No,4.15490196
CHEMBL3888930,"Inhibition Assay: The hERG inhibition study aims at quantifying the in vitro effects of compounds of the invention on the potassium-selective IKr current generated in normoxic conditions in stably transfected HEK 293 cells with the human ether-a-go-go-related gene (hERG). Whole-cell currents (acquisition by manual patch-clamp) elicited during a voltage pulse were recorded in baseline conditions and following application of tested compounds (5 minutes of exposure). The concentrations of tested compounds (0.3 μM; 3 μM; 10 μM; 30 μM) reflect a range believed to exceed the concentrations at expected efficacy doses in preclinical models. The pulses protocol applied is described as follow: the holding potential (every 3 seconds) was stepped from −80 mV to a maximum value of +40 mV, starting with −40 mV, in eight increments of +10 mV, for a period of 1 second. The membrane potential was then returned to −55 mV, after each of these incremented steps, for 1 second and finally repolarized to −80 mV for 1 second.",Cc1nsc(-c2nnc3n2CCN(C(=O)c2cc(F)c(F)c(F)c2F)[C@@H]3C)n1,,CHEMBL4113428,70,No,4.15490196
CHEMBL3888930,"Inhibition Assay: The hERG inhibition study aims at quantifying the in vitro effects of compounds of the invention on the potassium-selective IKr current generated in normoxic conditions in stably transfected HEK 293 cells with the human ether-a-go-go-related gene (hERG). Whole-cell currents (acquisition by manual patch-clamp) elicited during a voltage pulse were recorded in baseline conditions and following application of tested compounds (5 minutes of exposure). The concentrations of tested compounds (0.3 μM; 3 μM; 10 μM; 30 μM) reflect a range believed to exceed the concentrations at expected efficacy doses in preclinical models. The pulses protocol applied is described as follow: the holding potential (every 3 seconds) was stepped from −80 mV to a maximum value of +40 mV, starting with −40 mV, in eight increments of +10 mV, for a period of 1 second. The membrane potential was then returned to −55 mV, after each of these incremented steps, for 1 second and finally repolarized to −80 mV for 1 second.",Cc1nsc(-c2nnc3n2CCN(C(=O)c2ccc(F)cc2)[C@@H]3CCO)n1,,CHEMBL3608741,50,No,4.301029996
CHEMBL3888930,"Inhibition Assay: The hERG inhibition study aims at quantifying the in vitro effects of compounds of the invention on the potassium-selective IKr current generated in normoxic conditions in stably transfected HEK 293 cells with the human ether-a-go-go-related gene (hERG). Whole-cell currents (acquisition by manual patch-clamp) elicited during a voltage pulse were recorded in baseline conditions and following application of tested compounds (5 minutes of exposure). The concentrations of tested compounds (0.3 μM; 3 μM; 10 μM; 30 μM) reflect a range believed to exceed the concentrations at expected efficacy doses in preclinical models. The pulses protocol applied is described as follow: the holding potential (every 3 seconds) was stepped from −80 mV to a maximum value of +40 mV, starting with −40 mV, in eight increments of +10 mV, for a period of 1 second. The membrane potential was then returned to −55 mV, after each of these incremented steps, for 1 second and finally repolarized to −80 mV for 1 second.",CCc1noc(-c2nnc3n2CCN(C(=O)c2ccc(F)cc2)[C@@H]3C)n1,,CHEMBL4110286,70,No,4.15490196
CHEMBL3888930,"Inhibition Assay: The hERG inhibition study aims at quantifying the in vitro effects of compounds of the invention on the potassium-selective IKr current generated in normoxic conditions in stably transfected HEK 293 cells with the human ether-a-go-go-related gene (hERG). Whole-cell currents (acquisition by manual patch-clamp) elicited during a voltage pulse were recorded in baseline conditions and following application of tested compounds (5 minutes of exposure). The concentrations of tested compounds (0.3 μM; 3 μM; 10 μM; 30 μM) reflect a range believed to exceed the concentrations at expected efficacy doses in preclinical models. The pulses protocol applied is described as follow: the holding potential (every 3 seconds) was stepped from −80 mV to a maximum value of +40 mV, starting with −40 mV, in eight increments of +10 mV, for a period of 1 second. The membrane potential was then returned to −55 mV, after each of these incremented steps, for 1 second and finally repolarized to −80 mV for 1 second.",Cc1nsc(-c2nnc3n2CCN(C(=O)c2cccc(F)c2)[C@@H]3C)n1,,CHEMBL4111714,70,No,4.15490196
CHEMBL3888930,"Inhibition Assay: The hERG inhibition study aims at quantifying the in vitro effects of compounds of the invention on the potassium-selective IKr current generated in normoxic conditions in stably transfected HEK 293 cells with the human ether-a-go-go-related gene (hERG). Whole-cell currents (acquisition by manual patch-clamp) elicited during a voltage pulse were recorded in baseline conditions and following application of tested compounds (5 minutes of exposure). The concentrations of tested compounds (0.3 μM; 3 μM; 10 μM; 30 μM) reflect a range believed to exceed the concentrations at expected efficacy doses in preclinical models. The pulses protocol applied is described as follow: the holding potential (every 3 seconds) was stepped from −80 mV to a maximum value of +40 mV, starting with −40 mV, in eight increments of +10 mV, for a period of 1 second. The membrane potential was then returned to −55 mV, after each of these incremented steps, for 1 second and finally repolarized to −80 mV for 1 second.",Cc1nsc(-c2nnc3n2CCN(C(=O)c2cccc(Cl)c2)[C@@H]3C)n1,,CHEMBL4110770,70,No,4.15490196
CHEMBL3888930,"Inhibition Assay: The hERG inhibition study aims at quantifying the in vitro effects of compounds of the invention on the potassium-selective IKr current generated in normoxic conditions in stably transfected HEK 293 cells with the human ether-a-go-go-related gene (hERG). Whole-cell currents (acquisition by manual patch-clamp) elicited during a voltage pulse were recorded in baseline conditions and following application of tested compounds (5 minutes of exposure). The concentrations of tested compounds (0.3 μM; 3 μM; 10 μM; 30 μM) reflect a range believed to exceed the concentrations at expected efficacy doses in preclinical models. The pulses protocol applied is described as follow: the holding potential (every 3 seconds) was stepped from −80 mV to a maximum value of +40 mV, starting with −40 mV, in eight increments of +10 mV, for a period of 1 second. The membrane potential was then returned to −55 mV, after each of these incremented steps, for 1 second and finally repolarized to −80 mV for 1 second.",Cc1nsc(-c2nnc3n2CCN(C(=O)c2cc(F)cc(F)c2)[C@@H]3C)n1,,CHEMBL4112585,46,No,4.337242168
CHEMBL3888930,"Inhibition Assay: The hERG inhibition study aims at quantifying the in vitro effects of compounds of the invention on the potassium-selective IKr current generated in normoxic conditions in stably transfected HEK 293 cells with the human ether-a-go-go-related gene (hERG). Whole-cell currents (acquisition by manual patch-clamp) elicited during a voltage pulse were recorded in baseline conditions and following application of tested compounds (5 minutes of exposure). The concentrations of tested compounds (0.3 μM; 3 μM; 10 μM; 30 μM) reflect a range believed to exceed the concentrations at expected efficacy doses in preclinical models. The pulses protocol applied is described as follow: the holding potential (every 3 seconds) was stepped from −80 mV to a maximum value of +40 mV, starting with −40 mV, in eight increments of +10 mV, for a period of 1 second. The membrane potential was then returned to −55 mV, after each of these incremented steps, for 1 second and finally repolarized to −80 mV for 1 second.",Cc1nsc(-c2nnc3n2CCN(C(=O)c2ccc(F)cc2F)[C@@H]3C)n1,,CHEMBL4110224,70,No,4.15490196
CHEMBL3888930,"Inhibition Assay: The hERG inhibition study aims at quantifying the in vitro effects of compounds of the invention on the potassium-selective IKr current generated in normoxic conditions in stably transfected HEK 293 cells with the human ether-a-go-go-related gene (hERG). Whole-cell currents (acquisition by manual patch-clamp) elicited during a voltage pulse were recorded in baseline conditions and following application of tested compounds (5 minutes of exposure). The concentrations of tested compounds (0.3 μM; 3 μM; 10 μM; 30 μM) reflect a range believed to exceed the concentrations at expected efficacy doses in preclinical models. The pulses protocol applied is described as follow: the holding potential (every 3 seconds) was stepped from −80 mV to a maximum value of +40 mV, starting with −40 mV, in eight increments of +10 mV, for a period of 1 second. The membrane potential was then returned to −55 mV, after each of these incremented steps, for 1 second and finally repolarized to −80 mV for 1 second.",Cc1nsc(-c2nnc3n2CCN(C(=O)c2ccccc2)[C@@H]3C)n1,,CHEMBL3608740,50,No,4.301029996
CHEMBL3888930,"Inhibition Assay: The hERG inhibition study aims at quantifying the in vitro effects of compounds of the invention on the potassium-selective IKr current generated in normoxic conditions in stably transfected HEK 293 cells with the human ether-a-go-go-related gene (hERG). Whole-cell currents (acquisition by manual patch-clamp) elicited during a voltage pulse were recorded in baseline conditions and following application of tested compounds (5 minutes of exposure). The concentrations of tested compounds (0.3 μM; 3 μM; 10 μM; 30 μM) reflect a range believed to exceed the concentrations at expected efficacy doses in preclinical models. The pulses protocol applied is described as follow: the holding potential (every 3 seconds) was stepped from −80 mV to a maximum value of +40 mV, starting with −40 mV, in eight increments of +10 mV, for a period of 1 second. The membrane potential was then returned to −55 mV, after each of these incremented steps, for 1 second and finally repolarized to −80 mV for 1 second.",Cc1nsc(-c2nnc3n2CCN(C(=O)c2ccc(C(F)(F)F)cc2)[C@@H]3C)n1,,CHEMBL4109584,45,No,4.346787486
CHEMBL3888930,"Inhibition Assay: The hERG inhibition study aims at quantifying the in vitro effects of compounds of the invention on the potassium-selective IKr current generated in normoxic conditions in stably transfected HEK 293 cells with the human ether-a-go-go-related gene (hERG). Whole-cell currents (acquisition by manual patch-clamp) elicited during a voltage pulse were recorded in baseline conditions and following application of tested compounds (5 minutes of exposure). The concentrations of tested compounds (0.3 μM; 3 μM; 10 μM; 30 μM) reflect a range believed to exceed the concentrations at expected efficacy doses in preclinical models. The pulses protocol applied is described as follow: the holding potential (every 3 seconds) was stepped from −80 mV to a maximum value of +40 mV, starting with −40 mV, in eight increments of +10 mV, for a period of 1 second. The membrane potential was then returned to −55 mV, after each of these incremented steps, for 1 second and finally repolarized to −80 mV for 1 second.",CC[C@@H]1c2nnc(-c3nc(C)ns3)n2CCN1C(=O)c1ccc(F)cc1,,CHEMBL4112608,70,No,4.15490196
CHEMBL3888930,"Inhibition Assay: The hERG inhibition study aims at quantifying the in vitro effects of compounds of the invention on the potassium-selective IKr current generated in normoxic conditions in stably transfected HEK 293 cells with the human ether-a-go-go-related gene (hERG). Whole-cell currents (acquisition by manual patch-clamp) elicited during a voltage pulse were recorded in baseline conditions and following application of tested compounds (5 minutes of exposure). The concentrations of tested compounds (0.3 μM; 3 μM; 10 μM; 30 μM) reflect a range believed to exceed the concentrations at expected efficacy doses in preclinical models. The pulses protocol applied is described as follow: the holding potential (every 3 seconds) was stepped from −80 mV to a maximum value of +40 mV, starting with −40 mV, in eight increments of +10 mV, for a period of 1 second. The membrane potential was then returned to −55 mV, after each of these incremented steps, for 1 second and finally repolarized to −80 mV for 1 second.",CCC[C@@H]1c2nnc(-c3nc(C)ns3)n2CCN1C(=O)c1ccc(F)cc1,,CHEMBL4110242,61,No,4.214670165
CHEMBL3888930,"Inhibition Assay: The hERG inhibition study aims at quantifying the in vitro effects of compounds of the invention on the potassium-selective IKr current generated in normoxic conditions in stably transfected HEK 293 cells with the human ether-a-go-go-related gene (hERG). Whole-cell currents (acquisition by manual patch-clamp) elicited during a voltage pulse were recorded in baseline conditions and following application of tested compounds (5 minutes of exposure). The concentrations of tested compounds (0.3 μM; 3 μM; 10 μM; 30 μM) reflect a range believed to exceed the concentrations at expected efficacy doses in preclinical models. The pulses protocol applied is described as follow: the holding potential (every 3 seconds) was stepped from −80 mV to a maximum value of +40 mV, starting with −40 mV, in eight increments of +10 mV, for a period of 1 second. The membrane potential was then returned to −55 mV, after each of these incremented steps, for 1 second and finally repolarized to −80 mV for 1 second.",COc1cccc(C(=O)N2CCn3c(-c4nc(C)ns4)nnc3[C@H]2C)c1,,CHEMBL4114258,70,No,4.15490196
CHEMBL3888930,"Inhibition Assay: The hERG inhibition study aims at quantifying the in vitro effects of compounds of the invention on the potassium-selective IKr current generated in normoxic conditions in stably transfected HEK 293 cells with the human ether-a-go-go-related gene (hERG). Whole-cell currents (acquisition by manual patch-clamp) elicited during a voltage pulse were recorded in baseline conditions and following application of tested compounds (5 minutes of exposure). The concentrations of tested compounds (0.3 μM; 3 μM; 10 μM; 30 μM) reflect a range believed to exceed the concentrations at expected efficacy doses in preclinical models. The pulses protocol applied is described as follow: the holding potential (every 3 seconds) was stepped from −80 mV to a maximum value of +40 mV, starting with −40 mV, in eight increments of +10 mV, for a period of 1 second. The membrane potential was then returned to −55 mV, after each of these incremented steps, for 1 second and finally repolarized to −80 mV for 1 second.",Cc1nsc(-c2nnc3n2CCN(C(=O)c2ccc(C#N)cc2)[C@@H]3C)n1,,CHEMBL4107016,59,No,4.229147988
CHEMBL3888930,"Inhibition Assay: The hERG inhibition study aims at quantifying the in vitro effects of compounds of the invention on the potassium-selective IKr current generated in normoxic conditions in stably transfected HEK 293 cells with the human ether-a-go-go-related gene (hERG). Whole-cell currents (acquisition by manual patch-clamp) elicited during a voltage pulse were recorded in baseline conditions and following application of tested compounds (5 minutes of exposure). The concentrations of tested compounds (0.3 μM; 3 μM; 10 μM; 30 μM) reflect a range believed to exceed the concentrations at expected efficacy doses in preclinical models. The pulses protocol applied is described as follow: the holding potential (every 3 seconds) was stepped from −80 mV to a maximum value of +40 mV, starting with −40 mV, in eight increments of +10 mV, for a period of 1 second. The membrane potential was then returned to −55 mV, after each of these incremented steps, for 1 second and finally repolarized to −80 mV for 1 second.",CCc1noc(-c2nnc3n2CCN(C(=O)c2ccc(-c4cccs4)cc2)[C@@H]3C)n1,,CHEMBL4108623,32,No,4.494850022
CHEMBL3889165,"Binding Assay: Predictor hERG Assay test kits were obtained from Invitrogen (Carlsbad, Calif.). The binding assay was carried out according to the kit instructions. Fluorescence polarization measurements were made using EnVision Microplate Reader from Perkin-Elmer Instruments.",CS(=O)(=O)C1(c2nc(-c3cccc4[nH]ccc34)nc3c2OC[C@@H]2COCCN32)CCOCC1,,CHEMBL3921669,6000,No,2.22184875
CHEMBL3889165,"Binding Assay: Predictor hERG Assay test kits were obtained from Invitrogen (Carlsbad, Calif.). The binding assay was carried out according to the kit instructions. Fluorescence polarization measurements were made using EnVision Microplate Reader from Perkin-Elmer Instruments.",CNc1nc2ccccc2n1-c1nc2c(c(C(C)(C)S(C)(=O)=O)n1)OC[C@@H]1COCCN21,,CHEMBL3985847,4000,No,2.397940009
CHEMBL3999268,Inhibition of human ERG expressed in HEK293 cells,CN1C(=O)[C@@H](NC(=O)c2n[nH]c(Cc3ccccc3)n2)COc2ccccc21,J Med Chem,CHEMBL4071864,195,No,3.709965389
CHEMBL3999906,Inhibition of human ERG,C[C@]1(C(=O)O)CC[C@@](C)(c2nc(-c3ccc(C(=O)Nc4cc(C(F)(F)F)ccn4)cc3)c3c(N)nccn23)C1,Bioorg Med Chem Lett,CHEMBL4068919,54,No,4.26760624
CHEMBL4004026,Inhibition of human ERG,O=C(c1ccc(C[C@@H]2CC[C@H]([C@H](O)c3ccccc3)N2)cc1)N1CCN(Cc2ncn(CC(F)F)n2)CC1,Bioorg Med Chem Lett,CHEMBL4087670,34.01,No,4.468393368
CHEMBL4004026,Inhibition of human ERG,O=C(c1ccc(C[C@@H]2CC[C@H]([C@H](O)c3ccccc3)N2)cc1)N1CCN(Cc2nnn(CC3CC3)n2)CC1,Bioorg Med Chem Lett,CHEMBL4092912,39.38,No,4.404724288
CHEMBL4004312,Displacement of [35S]MK499 from human ERG expressed in HEK293 cells,N#Cc1ccc(CCN2CCN(CCc3ccc4c(c3)COC4=O)CC2)cc1F,Bioorg Med Chem Lett,CHEMBL2146873,0.17,Yes,6.769551079
CHEMBL4004312,Displacement of [35S]MK499 from human ERG expressed in HEK293 cells,Cc1c([C@@H](O)CN2CCC3(CC2)CCN(c2ccc(C#N)cn2)CC3)ccc2c1COC2=O,Bioorg Med Chem Lett,CHEMBL4070123,0.193,Yes,6.714442691
CHEMBL4004504,Inhibition of human ERG expressed in CHOK1 cells assessed as reduction in rapidly activating delayed rectifier cardiac potassium current by whole-cell voltage-patch clamp assay,CS(=O)(=O)Nc1cccc([C@H](c2ccc(F)cc2)C(c2cccnc2)c2cccnc2)n1,Bioorg Med Chem Lett,CHEMBL4065169,110,No,3.958607315
CHEMBL4004504,Inhibition of human ERG expressed in CHOK1 cells assessed as reduction in rapidly activating delayed rectifier cardiac potassium current by whole-cell voltage-patch clamp assay,O[C@@H](c1cccnc1-c1cc(Cl)cc(Cl)c1)C(c1cccnc1)c1cccnc1,Bioorg Med Chem Lett,CHEMBL4104525,128,No,3.89279003
CHEMBL4007981,Inhibition of human ERG expressed in CHO cells by Qpatch assay,CCN(CC)CCNC(=O)c1c(C)[nH]c(/C=C2\C(=O)Nc3ccc(F)cc32)c1C,Eur J Med Chem,CHEMBL535,0.5,Yes,6.301029996
CHEMBL4007981,Inhibition of human ERG expressed in CHO cells by Qpatch assay,COc1cc(N)c(Cl)cc1C(=O)NC1CCN(CCCOc2ccc(F)cc2)CC1OC,Eur J Med Chem,CHEMBL1729,0.15,Yes,6.823908741
CHEMBL4011543,Inhibition of human ERG,CCOC(=O)C1=C[C@]2(CC)CCCN3CCc4c(n1c1ccccc41)[C@@H]32,J Med Chem,CHEMBL71752,0.039,Yes,7.408935393
CHEMBL4011543,Inhibition of human ERG,CN1CCc2c(sc3c2c2ncnn2c(=O)n3Cc2ccc(Cl)cc2)C1,J Med Chem,CHEMBL4068450,0.069,Yes,7.161150909
CHEMBL4011543,Inhibition of human ERG,O=c1n(Cc2ccc(Cl)cc2)c2sc3c(c2c2ncnn12)CCN(CC1CC1)C3,J Med Chem,CHEMBL4086861,0.16,Yes,6.795880017
CHEMBL4011543,Inhibition of human ERG,O=C(C1CC1)N1CCc2c(sc3c2c2ncnn2c(=O)n3Cc2ccc(Cl)cc2)C1,J Med Chem,CHEMBL4074038,0.49,Yes,6.30980392
CHEMBL4011543,Inhibition of human ERG,O=c1n(Cc2ccc(Cl)cc2)c2sc3c(c2c2ncnn12)CCN(C1COC1)C3,J Med Chem,CHEMBL4084358,0.98,Yes,6.008773924
CHEMBL4011543,Inhibition of human ERG,O=c1n(Cc2ccc(Cl)cc2)c2sc3c(c2c2ncnn12)CCN(Cc1ccccc1)C3,J Med Chem,CHEMBL4102318,0.49,Yes,6.30980392
CHEMBL4011543,Inhibition of human ERG,O=c1n(Cc2ccccc2)c2sc3c(c2c2ncnn12)CCN(CC1CCOCC1)C3,J Med Chem,CHEMBL4069196,0.57,Yes,6.244125144
CHEMBL4011543,Inhibition of human ERG,O=c1n(Cc2ccc(Cl)cc2)c2sc3c(c2c2ncnn12)CCN(CC1CCOCC1)C3,J Med Chem,CHEMBL4090245,0.35,Yes,6.455931956
CHEMBL4011543,Inhibition of human ERG,O=c1n(Cc2ccc(Cl)cc2F)c2sc3c(c2c2ncnn12)CCN(CC1CCOCC1)C3,J Med Chem,CHEMBL4078578,0.61,Yes,6.214670165
CHEMBL4013657,Inhibition of human ERG by fluorescence polarization assay,N/C(CC(O)c1cc2c(F)cc(F)cc2c2cc(C(F)(F)F)ccc12)=N\N=C\c1ccc(F)cc1,J Med Chem,CHEMBL4081080,0.067,Yes,7.173925197
CHEMBL4013657,Inhibition of human ERG by fluorescence polarization assay,CCN(CC)Cc1cc(/C=N/N=C(\N)CC(O)c2cc3c(F)cc(F)cc3c3cc(C(F)(F)F)ccc23)ccc1O,J Med Chem,CHEMBL4105332,0.39,Yes,6.408935393
CHEMBL4013657,Inhibition of human ERG by fluorescence polarization assay,CCCCN(CCCC)CC(O)c1cc(Cl)cc2c1-c1ccc(Cl)cc1/C2=C/c1ccc(Cl)cc1,J Med Chem,CHEMBL38827,0.377,Yes,6.42365865
CHEMBL4013657,Inhibition of human ERG by fluorescence polarization assay,CCCCN(CCCC)CCC(O)c1cc2c(Cl)cc(Cl)cc2c2cc(C(F)(F)F)ccc12,J Med Chem,CHEMBL1107,0.156,Yes,6.806875402
CHEMBL4015066,Inhibition of human ERG,O=C(c1cc([C@H]2CCCN2c2cc(F)cc(F)c2)c2oc(N3CCOCC3)cc(=O)c2c1)N1CCOCC1,Bioorg Med Chem Lett,CHEMBL4060768,45,No,4.346787486
CHEMBL4015498,Inhibition of human ERG expressed in HEK293 cells by patch clamp method,Nc1ncc(-c2nc(NCc3ccccn3)c3c(-c4ccccc4)cccc3n2)cn1,J Med Chem,CHEMBL4076905,80,No,4.096910013
CHEMBL4015498,Inhibition of human ERG expressed in HEK293 cells by patch clamp method,COc1ncc(-c2nc(NCc3ccccn3)c3c(-c4ccccc4)cccc3n2)cn1,J Med Chem,CHEMBL4061436,66,No,4.180456064
CHEMBL4015498,Inhibition of human ERG expressed in HEK293 cells by patch clamp method,Oc1ccc(-c2nc(NCc3ccccn3)c3c(-c4ccccc4)cccc3n2)cn1,J Med Chem,CHEMBL4081790,0.5,Yes,6.301029996
CHEMBL4015498,Inhibition of human ERG expressed in HEK293 cells by patch clamp method,NS(=O)(=O)Nc1cncc(-c2nc(NCc3ccccn3)c3c(-c4ccccc4)cccc3n2)c1,J Med Chem,CHEMBL4076097,0.8,Yes,6.096910013
CHEMBL4015502,Inhibition of human ERG expressed in HEK293 cells by flux assay,NS(=O)(=O)c1ncccc1-c1nc(NCc2ccccn2)c2c(-c3ccccc3)cccc2n1,J Med Chem,CHEMBL4102183,36,No,4.443697499
CHEMBL4017034,Inhibition of human ERG,CN(C)c1ccc(C(=O)N(CCCCCC(=O)NO)CC(=O)NCc2ccccc2)cc1,J Med Chem,CHEMBL4069631,50.81594,No,4.294000036
CHEMBL4017034,Inhibition of human ERG,CN(C)c1ccc(C(=O)N(CCCCCC(=O)NO)CC(=O)NCc2ccccc2)cc1,J Med Chem,CHEMBL4069631,279.89813,No,3.553000003
CHEMBL4017034,Inhibition of human ERG,CN(C)c1ccc(C(=O)N(CC(=O)NC2CCCCC2)Cc2ccc(C(=O)NO)cc2)cc1,J Med Chem,CHEMBL4063658,52.11947,No,4.283000009
CHEMBL4017746,Inhibition of human ERG,N=C(Nc1ccc(I)cc1)NC12CC3CC(CC(C3)C1)C2,Bioorg Med Chem Lett,CHEMBL299499,0.4914,Yes,6.308564848
CHEMBL4017746,Inhibition of human ERG,N=C(NCCCOc1ccc(F)cc1)Nc1ccc(I)cc1,Bioorg Med Chem Lett,CHEMBL4098778,0.1091,Yes,6.962175249
CHEMBL4017746,Inhibition of human ERG,N=C(NCCCOc1ccc(F)cc1)Nc1ccc(Cl)cc1,Bioorg Med Chem Lett,CHEMBL4084182,0.216,Yes,6.665546249
CHEMBL4017746,Inhibition of human ERG,COc1ccc(NC(=N)NCCCOc2ccc(F)cc2)cc1,Bioorg Med Chem Lett,CHEMBL4092687,0.4168,Yes,6.38007229
CHEMBL4017747,Inhibition of human ERG expressed in CHOK1 cells by Qpatch clamp method,N=C(NCCCOc1ccc(F)cc1)Nc1ccc(Cl)cc1,Bioorg Med Chem Lett,CHEMBL4084182,0.43,Yes,6.366531544
CHEMBL4019656,Inhibition of human ERG expressed in CHO cells after 3 mins at -80 mV holding potential by automated patch clamp method,CN(C/C=C/c1ccc(-c2ccccc2)cc1)Cc1ccc2c(c1)OCCC2.Cl,J Med Chem,CHEMBL4064940,32.1,No,4.493494968
CHEMBL4019656,Inhibition of human ERG expressed in CHO cells after 3 mins at -80 mV holding potential by automated patch clamp method,CN(C/C=C/c1ccc(C(F)(F)F)c(F)c1)Cc1ccc2c(c1)OCCC2.Cl,J Med Chem,CHEMBL4092973,0.2,Yes,6.698970004
CHEMBL4022306,Inhibition of recombinant human ERG expressed in HEK293 cells after 9 mins by patch clamp method,Nc1ccc(F)cc1NC(=O)c1ccc(CNC(=O)/C=C/c2cccnc2)cc1,Bioorg Med Chem Lett,CHEMBL4087968,32,No,4.494850022
CHEMBL4022306,Inhibition of recombinant human ERG expressed in HEK293 cells after 9 mins by patch clamp method,Nc1ccccc1NC(=O)c1ccc(N2CCN(C(=O)/C=C/c3ccc(F)cc3)CC2)cc1,Bioorg Med Chem Lett,CHEMBL4096149,32.6,No,4.4867824
CHEMBL4026835,Inhibition of human ERG by fluorescently labeled tracer binding method,Cc1cccc(CCN2CCC(C(=O)c3ccc(NS(C)(=O)=O)cc3)CC2)n1,J Med Chem,CHEMBL327980,0.0012,Yes,8.920818754
CHEMBL4027157,Inhibition of human ERG expressed in CHO cells by automated patch clamp method,COc1ccc(CCN(C)CCCC(C#N)(c2ccc(OC)c(OC)c2)C(C)C)cc1OC.Cl,J Med Chem,CHEMBL1280,0.56,Yes,6.251811973
CHEMBL4027157,Inhibition of human ERG expressed in CHO cells by automated patch clamp method,CN(Cc1ccccn1)Cc1ccccc1CNc1ccnc2cc(Cl)ccc12,J Med Chem,CHEMBL4099387,0.87096,Yes,6.06000179
CHEMBL4027157,Inhibition of human ERG expressed in CHO cells by automated patch clamp method,CN(Cc1ccccn1)Cc1ccccc1CNc1ccnc2cc(Cl)ccc12,J Med Chem,CHEMBL4099387,0.87,Yes,6.060480747
CHEMBL4027662,Inhibition of human ERG expressed in CHO cells at -80 mV holding potential after 3 mins by QPatch test,CN(C/C=C/c1ccc(-c2ccccc2)cc1)Cc1coc2ccccc12.Cl,J Med Chem,CHEMBL4086008,34.8,No,4.458420756
CHEMBL4028623,Inhibition of human ERG expressed in HEK293 cells at -80 mV holding potential by manual-patch-clamp electrophysiology assay,CCOC(=O)C1=C(CN2CCOCC2)NC(n2cncn2)=NC1c1ccc(F)cc1Br,J Med Chem,CHEMBL4082519,0.7,Yes,6.15490196
CHEMBL4028623,Inhibition of human ERG expressed in HEK293 cells at -80 mV holding potential by manual-patch-clamp electrophysiology assay,CCOC(=O)C1=C(CN2CCOCC2)NC(c2nccn2C)=NC1c1ccc(F)cc1Br,J Med Chem,CHEMBL4079561,0.17,Yes,6.769551079
CHEMBL4028623,Inhibition of human ERG expressed in HEK293 cells at -80 mV holding potential by manual-patch-clamp electrophysiology assay,CCOC(=O)C1=C(CN2CCOCC2)NC(c2cccs2)=NC1c1ccc(F)cc1Br,J Med Chem,CHEMBL4077161,0.9,Yes,6.045757491
CHEMBL4028623,Inhibition of human ERG expressed in HEK293 cells at -80 mV holding potential by manual-patch-clamp electrophysiology assay,CCOC(=O)C1=C(CN2CCOCC2)NC(c2nccs2)=NC1c1ccccc1[N+](=O)[O-],J Med Chem,CHEMBL4103602,0.26,Yes,6.585026652
CHEMBL4028623,Inhibition of human ERG expressed in HEK293 cells at -80 mV holding potential by manual-patch-clamp electrophysiology assay,CCOC(=O)C1=C(CN2CCOCC2)NC(c2nccs2)=NC1c1ccc(Cl)cc1Cl,J Med Chem,CHEMBL4078766,0.3,Yes,6.522878745
CHEMBL4028623,Inhibition of human ERG expressed in HEK293 cells at -80 mV holding potential by manual-patch-clamp electrophysiology assay,CCOC(=O)C1=C(CN2CCOCC2)NC(c2nccs2)=NC1c1ccc(F)cc1Br,J Med Chem,CHEMBL3742114,0.86,Yes,6.065501549
CHEMBL4030012,Displacement of [35S]MK499 from human ERG expressed in HEK293 cells,Cc1c([C@@H](O)CN2CCC3(CC2)CCN(c2cc(-c4ccccc4)ns2)C3=O)ccc2c1COC2=O,Bioorg Med Chem Lett,CHEMBL4093627,0.0095,Yes,8.022276395
CHEMBL4030012,Displacement of [35S]MK499 from human ERG expressed in HEK293 cells,Cc1c([C@@H](O)CN2CCC3(CC2)CCN(c2cc(-c4ccccc4)no2)C3=O)ccc2c1COC2=O,Bioorg Med Chem Lett,CHEMBL4072929,0.054,Yes,7.26760624
CHEMBL4030012,Displacement of [35S]MK499 from human ERG expressed in HEK293 cells,Cc1c([C@@H](O)CN2CCC3(CC2)CC(=O)N(c2ccc(=O)n(C)n2)C3)ccc2c1COC2=O,Bioorg Med Chem Lett,CHEMBL4059965,36.4,No,4.438898616
CHEMBL4030012,Displacement of [35S]MK499 from human ERG expressed in HEK293 cells,Cc1c([C@@H](O)CN2CCC3(CC2)CCN(c2ccc(=O)n(C)n2)CC3)ccc2c1COC2=O,Bioorg Med Chem Lett,CHEMBL4076697,45,No,4.346787486
CHEMBL4030012,Displacement of [35S]MK499 from human ERG expressed in HEK293 cells,Cc1c([C@@H](O)CN2CCC3(CC2)CN(c2ccc(=O)n(C)n2)C(=O)CO3)ccc2c1COC2=O,Bioorg Med Chem Lett,CHEMBL4097415,46,No,4.337242168
CHEMBL4030416,Inhibition of human ERG expressed in HEK293 cells by patch clamp method,CC(=O)Nc1cc(-c2c(-c3ccc(F)cc3)nc([S+](C)[O-])n2C)ccn1,J Med Chem,CHEMBL1773422,213,No,3.671620397
CHEMBL4030416,Inhibition of human ERG expressed in HEK293 cells by patch clamp method,Cn1c([S+](C)[O-])nc(-c2ccc(F)cc2)c1-c1ccnc(N)c1,J Med Chem,CHEMBL4075428,83,No,4.080921908
CHEMBL4030710,Displacement of 3H-dofetilide from human ERG,Nc1nc(NCc2cc(C3CC3)on2)c2c(ccn2Cc2ccccn2)n1,J Med Chem,CHEMBL4073895,0.2,Yes,6.698970004
CHEMBL4030710,Displacement of 3H-dofetilide from human ERG,COc1ccc(Cn2ccc3nc(N)nc(NCc4cc(C)on4)c32)nc1OC,J Med Chem,CHEMBL4078859,0.7,Yes,6.15490196
CHEMBL4030710,Displacement of 3H-dofetilide from human ERG,Cc1cc(CNc2nc(N)nc3ccn(Cc4ccc(C(F)(F)F)cn4)c23)no1,J Med Chem,CHEMBL4088372,0.5,Yes,6.301029996
CHEMBL4030710,Displacement of 3H-dofetilide from human ERG,Cc1cc(CNc2nc(N)nc3ccn(Cc4ncccc4Cl)c23)no1,J Med Chem,CHEMBL4080513,0.9,Yes,6.045757491
CHEMBL4030710,Displacement of 3H-dofetilide from human ERG,Cc1cc(CNc2nc(N)nc3ccn(Cc4cc(Cl)ccn4)c23)no1,J Med Chem,CHEMBL4098533,0.5,Yes,6.301029996
CHEMBL4030710,Displacement of 3H-dofetilide from human ERG,Cc1cnc(COc2nc(N)nc3ccn(Cc4ccccn4)c23)s1,J Med Chem,CHEMBL4096097,44.7,No,4.349692477
CHEMBL4032610,Inhibition of full length human ERG expressed in CHO cells at -70 mV holding potential by patch clamp assay,CN1CCN(c2ccc(NC(=O)c3cc(N(C)Cc4ccc(C(F)(F)F)cc4)ncn3)cc2)CC1,J Med Chem,CHEMBL4070191,0.9,Yes,6.045757491
CHEMBL4033008,Displacement of [35S]-MK499 from human ERG expressed in HEK293 cell membranes,CN([C@H]1CC[C@H](n2cc(C(N)=O)c(Nc3ccc(Cl)cc3)n2)[C@@H](C#N)C1)C1(C)COC1,J Med Chem,CHEMBL4094682,46,No,4.337242168
CHEMBL4033008,Displacement of [35S]-MK499 from human ERG expressed in HEK293 cell membranes,N#C[C@H]1C[C@@H](N2CCC2)CC[C@@H]1n1cc(C(N)=O)c(Nc2ccc([C@H](O)C(F)(F)F)cc2)n1,J Med Chem,CHEMBL3703025,32,No,4.494850022
CHEMBL4033008,Displacement of [35S]-MK499 from human ERG expressed in HEK293 cell membranes,N#C[C@H]1CCOC[C@@H]1n1cc(C(N)=O)c(Nc2ccc(Cl)cc2)n1,J Med Chem,CHEMBL4089234,40,No,4.397940009
CHEMBL4033008,Displacement of [35S]-MK499 from human ERG expressed in HEK293 cell membranes,N#C[C@H]1CCOC[C@@H]1n1cc(C(N)=O)c(Nc2ccc(F)cc2)n1,J Med Chem,CHEMBL4104623,40,No,4.397940009
CHEMBL4033008,Displacement of [35S]-MK499 from human ERG expressed in HEK293 cell membranes,N#C[C@H]1CCOC[C@@H]1n1cc(C(N)=O)c(Nc2ccc(C3CC3)cc2)n1,J Med Chem,CHEMBL4077886,35,No,4.455931956
CHEMBL4033008,Displacement of [35S]-MK499 from human ERG expressed in HEK293 cell membranes,N#Cc1ccc(Nc2nn([C@H]3COCC[C@@H]3C#N)cc2C(N)=O)cc1,J Med Chem,CHEMBL4061128,40,No,4.397940009
CHEMBL4036596,Inhibition of human ERG,COc1ccc2ncc(F)c([C@@H](O)CC[C@@H]3CCN(C4CC(c5cc(F)ccc5F)C4)C[C@@H]3C(=O)O)c2n1,Bioorg Med Chem Lett,CHEMBL4078201,45,No,4.346787486
CHEMBL4036596,Inhibition of human ERG,COc1ccc2ncc(F)c([C@@H](O)CC[C@@H]3CCN(C4CC(c5cc(F)ccc5F)C4)C[C@@H]3C(=O)O)c2c1,Bioorg Med Chem Lett,CHEMBL4092041,85.9,No,4.066006836
CHEMBL4036596,Inhibition of human ERG,COc1ccc2ncc(F)c([C@@H](O)CC[C@@H]3CCN(C4CC(c5c(F)cccc5F)C4)C[C@@H]3C(=O)O)c2c1,Bioorg Med Chem Lett,CHEMBL4064317,45.3,No,4.343901798
CHEMBL4036596,Inhibition of human ERG,COc1ccc2nccc([C@@H](O)CC[C@@H]3CCN(C4CC(c5c(F)cccc5F)C4)C[C@@H]3C(=O)O)c2c1,Bioorg Med Chem Lett,CHEMBL2382343,47.6,No,4.322393047
CHEMBL4039279,Inhibition of human ERG expressed in CHO cells by automated patch clamp assay,Cc1cc(Oc2cncnc2)cc(C(=O)Nc2ccc(F)cn2)n1,J Med Chem,CHEMBL2386850,73.6,No,4.133122186
CHEMBL4040058,Inhibition of human ERG by patch clamp assay,O=C(CN1CCCC2=C1C(=O)N(C1CC1)C2=O)Nc1ccc(-c2cccnc2)nn1,J Med Chem,CHEMBL4087906,48,No,4.318758763
CHEMBL4042408,Inhibition of human ERG,N#Cc1c(N)ncnc1N1CCC[C@H]1c1nc2cccc(C#CCCCC(=O)N3CCOCC3)c2c(=O)n1-c1ccccc1,Eur J Med Chem,CHEMBL4080347,31.7,No,4.498940738
CHEMBL4042710,Inhibition of human ERG expressed in CHO cells at -80 mV holding potential after 5 mins by patch clamp assay,C[C@@]1(c2cc(CNCC3CC3)c(F)cc2F)CCSC(N)=N1,J Med Chem,CHEMBL4064148,33,No,4.48148606
CHEMBL4042710,Inhibition of human ERG expressed in CHO cells at -80 mV holding potential after 5 mins by patch clamp assay,C[C@@]1(c2cc(CNC3CC3)c(F)cc2F)CCSC(N)=N1,J Med Chem,CHEMBL4085715,49.2,No,4.308034897
CHEMBL4046796,Inhibition of human ERG,O=C(c1ccccc1)N1CCc2oc(-c3ccc(F)cn3)nc2C1,Bioorg Med Chem Lett,CHEMBL4060556,64,No,4.193820026
CHEMBL4046796,Inhibition of human ERG,O=C(c1cccc(F)c1)N1CCc2oc(-c3ccc(F)cn3)nc2C1,Bioorg Med Chem Lett,CHEMBL4102181,74,No,4.13076828
CHEMBL4047735,Displacement of [3H]-Dofetilide from recombinant human ERG expressed in CHOK1 cell membranes incubated for 4 hrs under dark condition by luminescence assay,CN1CCCC(n2nc(Cc3ccc(Cl)cc3)c3ccccc3c2=O)CC1,Bioorg Med Chem Lett,CHEMBL639,0.1,Yes,7
CHEMBL4047735,Displacement of [3H]-Dofetilide from recombinant human ERG expressed in CHOK1 cell membranes incubated for 4 hrs under dark condition by luminescence assay,COCCCC(=O)NCCN1CCC[C@@H]1Cn1nc(Cc2ccc(Cl)cc2)c2ccccc2c1=O.Cl.Cl,Bioorg Med Chem Lett,CHEMBL4060529,0.39811,Yes,6.399996913
CHEMBL4047735,Displacement of [3H]-Dofetilide from recombinant human ERG expressed in CHOK1 cell membranes incubated for 4 hrs under dark condition by luminescence assay,CCCCc1cc(OC2CCN(CCCS(=O)(=O)CC)CC2)c2ncccc2c1.Cl.Cl,Bioorg Med Chem Lett,CHEMBL4098917,0.07586,Yes,7.119987162
CHEMBL4047735,Displacement of [3H]-Dofetilide from recombinant human ERG expressed in CHOK1 cell membranes incubated for 4 hrs under dark condition by luminescence assay,CCCCc1cc(OC2CCN(CCCS(=O)(=O)CCC)CC2)c2ncccc2c1.Cl.Cl,Bioorg Med Chem Lett,CHEMBL4080880,0.02884,Yes,7.540004744
CHEMBL4047735,Displacement of [3H]-Dofetilide from recombinant human ERG expressed in CHOK1 cell membranes incubated for 4 hrs under dark condition by luminescence assay,CCCCc1cc(OC2CCN(CCCS(=O)(=O)C(C)C)CC2)c2ncccc2c1.Cl.Cl,Bioorg Med Chem Lett,CHEMBL4102287,0.0912,Yes,7.040005162
CHEMBL4047735,Displacement of [3H]-Dofetilide from recombinant human ERG expressed in CHOK1 cell membranes incubated for 4 hrs under dark condition by luminescence assay,CCCCc1cc(OC2CCN(CCCS(=O)(=O)C(C)(C)C)CC2)c2ncccc2c1,Bioorg Med Chem Lett,CHEMBL4084325,0.46774,Yes,6.329995489
CHEMBL4047735,Displacement of [3H]-Dofetilide from recombinant human ERG expressed in CHOK1 cell membranes incubated for 4 hrs under dark condition by luminescence assay,CCCCc1cc(OC2CCN(CCCCS(=O)(=O)C(C)(C)C)CC2)c2ncccc2c1.Cl.Cl,Bioorg Med Chem Lett,CHEMBL4095759,0.302,Yes,6.519993057
CHEMBL4047735,Displacement of [3H]-Dofetilide from recombinant human ERG expressed in CHOK1 cell membranes incubated for 4 hrs under dark condition by luminescence assay,CCCCc1cc(OC2CCN(CCC(C)S(=O)(=O)CC)CC2)c2ncccc2c1.Cl.Cl,Bioorg Med Chem Lett,CHEMBL4068414,0.19953,Yes,6.699991797
CHEMBL4047735,Displacement of [3H]-Dofetilide from recombinant human ERG expressed in CHOK1 cell membranes incubated for 4 hrs under dark condition by luminescence assay,CCCCc1cc(OC2CCN(CCC(C)S(=O)(=O)CC)CC2)c2ncccc2c1.Cl.Cl,Bioorg Med Chem Lett,CHEMBL4068414,0.13183,Yes,6.879985748
CHEMBL4047735,Displacement of [3H]-Dofetilide from recombinant human ERG expressed in CHOK1 cell membranes incubated for 4 hrs under dark condition by luminescence assay,CCCCc1cc(OC2CCN(CCNS(=O)(=O)CC)CC2)c2ncccc2c1.Cl.Cl,Bioorg Med Chem Lett,CHEMBL4079248,0.07586,Yes,7.119987162
CHEMBL4047735,Displacement of [3H]-Dofetilide from recombinant human ERG expressed in CHOK1 cell membranes incubated for 4 hrs under dark condition by luminescence assay,CCCCc1cc(OC2CCN(CCCNS(=O)(=O)CC)CC2)c2ncccc2c1.Cl.Cl,Bioorg Med Chem Lett,CHEMBL4080166,0.0631,Yes,7.199970641
CHEMBL4047735,Displacement of [3H]-Dofetilide from recombinant human ERG expressed in CHOK1 cell membranes incubated for 4 hrs under dark condition by luminescence assay,CCCCc1cc(OC2CCN(CCCCNS(C)(=O)=O)CC2)c2ncccc2c1.Cl.Cl,Bioorg Med Chem Lett,CHEMBL4098192,0.01995,Yes,7.7000571
CHEMBL4047735,Displacement of [3H]-Dofetilide from recombinant human ERG expressed in CHOK1 cell membranes incubated for 4 hrs under dark condition by luminescence assay,CCCCc1cc(OC2CCN(CCCCNS(=O)(=O)CC)CC2)c2ncccc2c1.Cl.Cl,Bioorg Med Chem Lett,CHEMBL4088036,0.07762,Yes,7.110026362
CHEMBL4047735,Displacement of [3H]-Dofetilide from recombinant human ERG expressed in CHOK1 cell membranes incubated for 4 hrs under dark condition by luminescence assay,CCCCc1cc(OC2CCN(CCCCNS(=O)(=O)CCC)CC2)c2ncccc2c1.Cl.Cl,Bioorg Med Chem Lett,CHEMBL4059750,0.0871,Yes,7.059981845
CHEMBL4047735,Displacement of [3H]-Dofetilide from recombinant human ERG expressed in CHOK1 cell membranes incubated for 4 hrs under dark condition by luminescence assay,CCCCc1cc(OC2CCN(CCCCNS(=O)(=O)C(C)C)CC2)c2ncccc2c1.Cl.Cl,Bioorg Med Chem Lett,CHEMBL4060765,0.12882,Yes,6.890016705
CHEMBL4047735,Displacement of [3H]-Dofetilide from recombinant human ERG expressed in CHOK1 cell membranes incubated for 4 hrs under dark condition by luminescence assay,CCCCc1cc(OC2CCN(CCCCNS(=O)(=O)CC(C)C)CC2)c2ncccc2c1.Cl.Cl,Bioorg Med Chem Lett,CHEMBL4082646,0.04365,Yes,7.360015752
CHEMBL4047735,Displacement of [3H]-Dofetilide from recombinant human ERG expressed in CHOK1 cell membranes incubated for 4 hrs under dark condition by luminescence assay,CCCCc1cc(OC2CCN(CCCCNS(=O)(=O)C3CCCCC3)CC2)c2ncccc2c1.Cl.Cl,Bioorg Med Chem Lett,CHEMBL4088039,0.0182,Yes,7.739928612
CHEMBL4047735,Displacement of [3H]-Dofetilide from recombinant human ERG expressed in CHOK1 cell membranes incubated for 4 hrs under dark condition by luminescence assay,CCCCc1cc(OC2CCN(CCCCN(C)S(=O)(=O)CC)CC2)c2ncccc2c1.Cl.Cl,Bioorg Med Chem Lett,CHEMBL4065123,0.25119,Yes,6.599997654
CHEMBL4047735,Displacement of [3H]-Dofetilide from recombinant human ERG expressed in CHOK1 cell membranes incubated for 4 hrs under dark condition by luminescence assay,CCCCc1cc(OC2CCN(CCS(=O)(=O)NC(C)(C)C)CC2)c2ncccc2c1,Bioorg Med Chem Lett,CHEMBL4090136,0.63096,Yes,6.199998172
CHEMBL4047735,Displacement of [3H]-Dofetilide from recombinant human ERG expressed in CHOK1 cell membranes incubated for 4 hrs under dark condition by luminescence assay,CCCCc1cc(OC2CCN(CCCS(=O)(=O)NC(C)(C)C)CC2)c2ncccc2c1.Cl.Cl,Bioorg Med Chem Lett,CHEMBL4069073,0.28184,Yes,6.54999737
CHEMBL4047735,Displacement of [3H]-Dofetilide from recombinant human ERG expressed in CHOK1 cell membranes incubated for 4 hrs under dark condition by luminescence assay,CCCCc1cc(OC2CCN(CCCCS(=O)(=O)NCCC)CC2)c2ncccc2c1,Bioorg Med Chem Lett,CHEMBL4063163,0.0955,Yes,7.019996628
CHEMBL4048343,Inhibition of [3H]-astemizole binding to human ERG expressed in HEK293 cell membranes by scintillation counting method,COc1ccc(CCN2CCC(Nc3nc4ccccc4n3Cc3ccc(F)cc3)CC2)cc1,J Med Chem,CHEMBL296419,0.014,Yes,7.853871964
CHEMBL4050158,Inhibition of MK499 binding to human ERG,O=C(O)c1ccc2c(c1)C(=O)OC21CCN(c2ccc(-c3nc4cc(C(F)(F)F)ccc4[nH]3)cn2)CC1,J Med Chem,CHEMBL4091946,0.56,Yes,6.251811973
CHEMBL4050158,Inhibition of MK499 binding to human ERG,O=C(O)CC1CCC2(CCN(c3ccc(-c4nc5cc(C(F)(F)F)ccc5[nH]4)cn3)CC2)OC1,J Med Chem,CHEMBL4060355,0.8,Yes,6.096910013
CHEMBL4051787,Inhibition of human ERG assessed as reduction of K+ current,COc1ccc2ccc(=O)n(C[C@H](N)[C@@H]3CC[C@@H](NCc4ccc5c(n4)NC(=O)CO5)CO3)c2n1,J Med Chem,CHEMBL4094942,52,No,4.283996656
CHEMBL4052442,Inhibition of human ERG expressed in HEK293 cells by patch clamp method,Cc1cc(/C=C/C#N)cc(C)c1Oc1nc(NC2CCN(Cc3ccc(S(N)(=O)=O)cc3)CC2)nc2ccsc12,J Med Chem,CHEMBL4094163,0.186,Yes,6.730487056
CHEMBL4052442,Inhibition of human ERG expressed in HEK293 cells by patch clamp method,CC(C)(C)c1ccc(C(O)CCCN2CCC(C(O)(c3ccccc3)c3ccccc3)CC2)cc1,J Med Chem,CHEMBL17157,0.022,Yes,7.657577319
CHEMBL4053853,Inhibition of human ERG expressed in HEK293 cells by lonWorks Quattro analysis,C=CC(=O)Nc1cc(Nc2nccc(-c3cn(C)c4ccccc34)n2)c(OC)cc1N(C)CCN(C)C,Eur J Med Chem,CHEMBL3353410,0.57,Yes,6.244125144
CHEMBL4054843,Inhibition of human ERG by patch clamp method,CC1(C)[C@H](Nc2c(C(N)=O)cnn3cc(-c4ccccc4)cc23)CC[C@]1(C)N,Bioorg Med Chem Lett,CHEMBL4096145,0.3,Yes,6.522878745
CHEMBL4054845,Inhibition of human ERG by flux-based assay,CC1(C)[C@H](Nc2c(C(N)=O)cnn3cc(-c4ccnc(F)c4)cc23)CC[C@]1(C)N,Bioorg Med Chem Lett,CHEMBL4104127,41,No,4.387216143
CHEMBL4054845,Inhibition of human ERG by flux-based assay,CC1(C)[C@H](Nc2c(C(N)=O)cnn3cc(-c4ccc(F)nc4)cc23)CC[C@]1(C)N,Bioorg Med Chem Lett,CHEMBL4098840,35,No,4.455931956
CHEMBL4057949,Inhibition of human ERG by [35S]-MK499 displacement or iKr channel assay,Nc1nccn2c([C@@H]3CCCN(C4CCOCC4)C3)nc(-c3ccc(C(=O)Nc4cc(C(F)(F)F)ccn4)cc3F)c12,Bioorg Med Chem Lett,CHEMBL4077588,0.1,Yes,7
CHEMBL4057949,Inhibition of human ERG by [35S]-MK499 displacement or iKr channel assay,CC1(C(=O)N2CC(c3nc(-c4ccc(C(=O)Nc5cc(C(F)(F)F)ccn5)cc4)c4c(N)nccn34)C2)COC1,Bioorg Med Chem Lett,CHEMBL4086348,0.4,Yes,6.397940009
CHEMBL4124237,Inhibition of human ERG,CC(=O)Nc1nc(C)c(-c2cc3c(c(S(C)(=O)=O)c2)C(=O)N([C@@H](C)C2CC2)C3)s1,J Med Chem,CHEMBL4126156,31.62278,No,4.499999953
CHEMBL4124696,Inhibition of human ERG by patch clamp method,CN(C)c1cncc(-c2ccc(C(=O)N(c3ncccc3Cl)[C@@H]3CCCNC3)cc2)n1,J Med Chem,CHEMBL4127311,43.2,No,4.364516253
CHEMBL4124696,Inhibition of human ERG by patch clamp method,Cc1cncc(-c2ccc(C(=O)N(c3ncccc3Cl)[C@@H]3CCCNC3)cc2)n1,J Med Chem,CHEMBL4127458,59.8,No,4.223298816
CHEMBL4136264,Inhibition of human ERG,COC(=O)c1ccc2c(c1)NC(=O)/C2=C(\Nc1ccc(N2C(=O)CC[C@@H]2CN2CCN(C)CC2)cc1)c1ccccc1,ACS Med Chem Lett,CHEMBL4170680,0.0014,Yes,8.853871964
CHEMBL4136264,Inhibition of human ERG,COC(=O)c1ccc2c(c1)NC(=O)/C2=C(\Nc1ccc(N2C(=O)CC[C@H]2CN2CCN(C)CC2)cc1)c1ccccc1,ACS Med Chem Lett,CHEMBL4171244,0.00095,Yes,9.022276395
CHEMBL4136264,Inhibition of human ERG,COC(=O)c1ccc2c(c1)NC(=O)/C2=C(\Nc1ccc(N(C)C(=O)CN2CCN(C)CC2)cc1)c1ccccc1,ACS Med Chem Lett,CHEMBL502835,0.0026,Yes,8.585026652
CHEMBL4137254,Inhibition of human ERG expressed in CHO cells,CN(C)CCNC(=O)[C@H]1c2ccccc2C[C@@H]1NC(=O)c1cc2ccccc2[nH]1,J Med Chem,CHEMBL4164328,31.62278,No,4.499999953
CHEMBL4137526,Inhibition of radioligand binding to human ERG expressed in HEK293 cell membranes by scintillation counting method,CCCC[C@@H](CCO)Nc1nc(N)nc2cccc(C)c12,J Med Chem,CHEMBL4162750,0.6,Yes,6.22184875
CHEMBL4143975,Inhibition of human ERG expressed in HEK293 cells by patch clamp assay,O=C(CCN1CCN(C(=O)OCc2cc(Cl)cc(Cl)c2)CC1)c1ccc2[nH]c(=O)oc2c1,ACS Med Chem Lett,CHEMBL3186509,0.48,Yes,6.318758763
CHEMBL4146889,Inhibition of human ERG expressed in CHO cells at holding potential of -80 mV by whole cell Qpatch assay,CN(C/C=C/C=C/c1ccc(C(F)(F)F)cc1F)Cc1ccc2c(c1)OCO2.Cl,Eur J Med Chem,CHEMBL4162120,0.014,Yes,7.853871964
CHEMBL4146889,Inhibition of human ERG expressed in CHO cells at holding potential of -80 mV by whole cell Qpatch assay,CN(C/C=C/c1ccc(F)cc1C(F)(F)F)Cc1ccc2c(c1)OCO2.Cl,Eur J Med Chem,CHEMBL4161555,0.00422,Yes,8.374687549
CHEMBL4149876,Inhibition of human ERG expressed in HEK293 cells assessed as reduction in peak tail current after 2 to 5 mins by patch clamp based electrophysiology assay,O=C1[C@H](N2CCC(c3ccc(O)cc3)CC2)CCN1Cc1ccc(F)cc1,ACS Med Chem Lett,CHEMBL4111330,0.62,Yes,6.207608311
CHEMBL4149876,Inhibition of human ERG expressed in HEK293 cells assessed as reduction in peak tail current after 2 to 5 mins by patch clamp based electrophysiology assay,Cc1ccc(CN2CC[C@@H](N3CCC(c4ccc(O)cc4)CC3)C2=O)cc1,ACS Med Chem Lett,CHEMBL4115628,0.4,Yes,6.397940009
CHEMBL4151701,Inhibition of human ERG,O=S(=O)(CC1CC1)NCCOc1ccc2c(c1)[C@@H](Cc1ccccc1)[C@@H](N1CCC1)CC2,J Med Chem,CHEMBL4173253,0.08,Yes,7.096910013
CHEMBL4157557,Inhibition of human ERG expressed in CHOK1 cells incubated for 600 secs at -80 mV holding potential by automated patch clamp assay,C[C@@H]1CN(CC(=O)N2CC(C)(C)c3nc(CO)c(Cc4ccc(F)cc4)cc32)[C@@H](CN2CCOC[C@H]2C)CN1,J Med Chem,CHEMBL4173974,69,No,4.161150909
CHEMBL4180224,Inhibition of human ERG expressed in Xenopus laevis oocytes by two-electrode voltage clamp assay,COc1ccc(CCN2CCC(Nc3nc4ccccc4n3Cc3ccc(F)cc3)CC2)cc1,Bioorg Med Chem,CHEMBL296419,0.3047,Yes,6.516127546
CHEMBL4180224,Inhibition of human ERG expressed in Xenopus laevis oocytes by two-electrode voltage clamp assay,COc1ccc(CCN2CCC(Nc3nc4ccccc4n3Cc3ccc(F)cc3F)CC2)cc1,Bioorg Med Chem,CHEMBL4208355,0.178,Yes,6.749579998
CHEMBL4180224,Inhibition of human ERG expressed in Xenopus laevis oocytes by two-electrode voltage clamp assay,COc1ccc(CCN2CCC(Nc3nc4ccccc4[nH]3)CC2)cc1,Bioorg Med Chem,CHEMBL4213322,0.1639,Yes,6.785421046
CHEMBL4180224,Inhibition of human ERG expressed in Xenopus laevis oocytes by two-electrode voltage clamp assay,CCCCCCn1c(NC2CCN(CCc3ccc(OC)cc3)CC2)nc2ccccc21,Bioorg Med Chem,CHEMBL4217209,0.02996,Yes,7.523458191
CHEMBL4180224,Inhibition of human ERG expressed in Xenopus laevis oocytes by two-electrode voltage clamp assay,COc1ccc(CCN2CCC(Nc3nc4ccccc4n3CCC(C)C)CC2)cc1,Bioorg Med Chem,CHEMBL4217155,0.2117,Yes,6.674279142
CHEMBL4180224,Inhibition of human ERG expressed in Xenopus laevis oocytes by two-electrode voltage clamp assay,COc1ccc(CCN2CCC(Nc3nc4ccccc4n3CC3CCCCC3)CC2)cc1,Bioorg Med Chem,CHEMBL4207128,0.00327,Yes,8.485452247
CHEMBL4181645,Inhibition of human ERG,COc1nc2ccc(Br)cc2cc1[C@@H](c1ccccc1)[C@@](O)(CCN(C)C)c1cccc2ccccc12,Bioorg Med Chem Lett,CHEMBL376488,0.37,Yes,6.431798276
CHEMBL4181645,Inhibition of human ERG,COc1nc2ccc(Br)cc2cc1[C@@H](c1cc(C)c(C)s1)[C@@](O)(CCN(C)C)c1cccc(F)c1,Bioorg Med Chem Lett,CHEMBL4206467,0.88,Yes,6.055517328
CHEMBL4181645,Inhibition of human ERG,COc1nc2ccc(Br)cc2cc1[C@@H](c1ccc(N(C)C)nc1)[C@@](O)(CCN(C)C)c1cccc(F)c1,Bioorg Med Chem Lett,CHEMBL4204414,0.89,Yes,6.050609993
CHEMBL4181645,Inhibition of human ERG,CCSc1ccc([C@H](c2cc3cc(Br)ccc3nc2OC)[C@@](O)(CCN(C)C)c2cccc(F)c2)cn1,Bioorg Med Chem Lett,CHEMBL4212501,0.46,Yes,6.337242168
CHEMBL4181645,Inhibition of human ERG,COc1nc2ccc(Br)cc2cc1[C@@H](c1ccnc(OC)c1OC)[C@@](O)(CCN(C)C)c1cccc(C)c1,Bioorg Med Chem Lett,CHEMBL4213428,0.53,Yes,6.27572413
CHEMBL4181845,Inhibition of human ERG,COCC(=O)O[C@]1(CCN(C)CCCc2nc3ccccc3[nH]2)CCc2cc(F)ccc2[C@@H]1C(C)C,J Med Chem,CHEMBL45816,0.58,Yes,6.236572006
CHEMBL4183120,Inhibition of human ERG expressed in CHOK1 cells for 5 mins at -80 mV holding potential by patch clamp method,C[C@H]1C[C@H]2CSC(N)=N[C@@]2(c2ccccc2C(F)(F)F)CO1,J Med Chem,CHEMBL4209994,55.4,No,4.256490235
CHEMBL4183120,Inhibition of human ERG expressed in CHOK1 cells for 5 mins at -80 mV holding potential by patch clamp method,C[C@H]1C[C@H]2CSC(N)=N[C@@]2(c2ccccc2)CO1,J Med Chem,CHEMBL4207711,85.7,No,4.067019178
CHEMBL4183120,Inhibition of human ERG expressed in CHOK1 cells for 5 mins at -80 mV holding potential by patch clamp method,COc1ccccc1[C@]12CO[C@@H](C)C[C@H]1CSC(N)=N2,J Med Chem,CHEMBL4209354,85.6,No,4.067526235
CHEMBL4183120,Inhibition of human ERG expressed in CHOK1 cells for 5 mins at -80 mV holding potential by patch clamp method,C[C@H]1C[C@H]2CSC(N)=N[C@@]2(c2ccsc2)CO1,J Med Chem,CHEMBL4203347,39.9,No,4.399027104
CHEMBL4183120,Inhibition of human ERG expressed in CHOK1 cells for 5 mins at -80 mV holding potential by patch clamp method,COc1cnc(C(=O)Nc2csc([C@]34CO[C@@H](C)C[C@H]3CSC(N)=N4)n2)cn1,J Med Chem,CHEMBL3941301,43,No,4.366531544
CHEMBL4184343,Inhibition of human ERG,CCN(CC)[C@@H](C)CNC(=O)c1ccnc(-c2cnn3ccc(-c4cccs4)nc23)c1,Bioorg Med Chem Lett,CHEMBL4217261,0.718,Yes,6.143875556
CHEMBL4184689,Inhibition of human ERG expressed in HEK293 cells at holding potential of -80 mV by whole cell patch clamp assay,CNC(=O)C(CCN1CCC(O)(c2ccc(Cl)cc2)CC1)(c1ccccc1)c1ccccc1,Bioorg Med Chem Lett,CHEMBL1627,0.245,Yes,6.610833916
CHEMBL4184689,Inhibition of human ERG expressed in HEK293 cells at holding potential of -80 mV by whole cell patch clamp assay,CN(C)C(=O)C(CCN1CCC(O)(c2ccc(Cl)cc2)CC1)(c1ccccc1)c1ccccc1,Bioorg Med Chem Lett,CHEMBL841,0.033,Yes,7.48148606
CHEMBL4186330,Displacement of [3H]Dofetilide from human ERG expressed in HEK293 cells after 60 mins by scintillation spectrometry,COc1ccccc1CCN1CCC(CCc2ccccc2OCCF)CC1.Cl,Bioorg Med Chem Lett,CHEMBL4212482,0.43,Yes,6.366531544
CHEMBL4186330,Displacement of [3H]Dofetilide from human ERG expressed in HEK293 cells after 60 mins by scintillation spectrometry,Cl.FCCOc1ccccc1CCC1CCN(CCc2ccccc2)CC1,Bioorg Med Chem Lett,CHEMBL4208760,0.76,Yes,6.119186408
CHEMBL4186330,Displacement of [3H]Dofetilide from human ERG expressed in HEK293 cells after 60 mins by scintillation spectrometry,COc1ccc(CCN2CCC(CCc3cccc(OCCF)c3)CC2)cc1.Cl,Bioorg Med Chem Lett,CHEMBL4213543,0.28,Yes,6.552841969
CHEMBL4186330,Displacement of [3H]Dofetilide from human ERG expressed in HEK293 cells after 60 mins by scintillation spectrometry,COc1ccccc1CCN1CCC(CCc2cccc(OCCF)c2)CC1.Cl,Bioorg Med Chem Lett,CHEMBL4218476,0.8,Yes,6.096910013
CHEMBL4186330,Displacement of [3H]Dofetilide from human ERG expressed in HEK293 cells after 60 mins by scintillation spectrometry,Cl.FCCOc1cccc(CCC2CCN(CCc3ccccc3)CC2)c1,Bioorg Med Chem Lett,CHEMBL4209141,0.75,Yes,6.124938737
CHEMBL4186330,Displacement of [3H]Dofetilide from human ERG expressed in HEK293 cells after 60 mins by scintillation spectrometry,COc1ccc(CCN2CCC(CCc3ccccc3OCCF)CC2)cc1.Cl,Bioorg Med Chem Lett,CHEMBL4203660,0.35,Yes,6.455931956
CHEMBL4186330,Displacement of [3H]Dofetilide from human ERG expressed in HEK293 cells after 60 mins by scintillation spectrometry,Cl.FCCOc1ccccc1CCC1CCN(CCc2ccccc2Cl)CC1,Bioorg Med Chem Lett,CHEMBL4210865,0.69,Yes,6.161150909
CHEMBL4186330,Displacement of [3H]Dofetilide from human ERG expressed in HEK293 cells after 60 mins by scintillation spectrometry,Cl.FCCOc1ccccc1CCC1CCN(CCc2ccc(F)cc2)CC1,Bioorg Med Chem Lett,CHEMBL4204715,0.38,Yes,6.420216403
CHEMBL4186330,Displacement of [3H]Dofetilide from human ERG expressed in HEK293 cells after 60 mins by scintillation spectrometry,Cl.FCCOc1ccc(CCN2CCC(CCc3ccccc3)CC2)cc1,Bioorg Med Chem Lett,CHEMBL4209058,0.35,Yes,6.455931956
CHEMBL4186330,Displacement of [3H]Dofetilide from human ERG expressed in HEK293 cells after 60 mins by scintillation spectrometry,Cl.FCCOc1cccc(CCN2CCC(CCc3ccccc3)CC2)c1,Bioorg Med Chem Lett,CHEMBL4213979,0.41,Yes,6.387216143
CHEMBL4186330,Displacement of [3H]Dofetilide from human ERG expressed in HEK293 cells after 60 mins by scintillation spectrometry,Cl.Cl.FCCOc1ccccc1CCN1CCN(CCc2ccccc2Cl)CC1,Bioorg Med Chem Lett,CHEMBL4202598,0.85,Yes,6.070581074
CHEMBL4189989,Inhibition of human ERG,CCN(CC)CC.NC(=O)c1ccc(-c2cc(C(=O)O)cc(-n3cc(-c4ccc(C(F)(F)F)cc4)nn3)c2)cc1,J Med Chem,CHEMBL4211068,0.166,Yes,6.779891912
CHEMBL4193795,Inhibition of human ERG expressed in CHO-K1 cells by Qpatch assay,O=C1CN(c2ccncc2)CCN1CCCCCOc1ccc(-c2ccc(Cl)cc2)cc1,ACS Med Chem Lett,CHEMBL4218176,0.37,Yes,6.431798276
CHEMBL4193795,Inhibition of human ERG expressed in CHO-K1 cells by Qpatch assay,CCO/N=C/c1ccc(OCCC(C)CCN2CCN(c3ccnc(N)c3)C2=O)cc1,ACS Med Chem Lett,CHEMBL4210399,0.8,Yes,6.096910013
CHEMBL4195808,Inhibition of human ERG by fluorescence polarization assay,CNC(=O)c1cnc(N)c(O[C@H]2CN(C(=O)Cc3ccc(OC(F)(F)F)cc3)CC2(F)F)c1,J Med Chem,CHEMBL4207042,79,No,4.102372909
CHEMBL4195808,Inhibition of human ERG by fluorescence polarization assay,CCNC(=O)c1cnc(N)c(O[C@H]2CN(C(=O)Cc3ccc(OC(F)(F)F)cc3)CC2(F)F)c1,J Med Chem,CHEMBL4216371,43,No,4.366531544
CHEMBL4195808,Inhibition of human ERG by fluorescence polarization assay,CC(C)(O)COc1ccc(C(N)=O)c(O[C@H]2CCN(C(=O)Cc3ccc(OC(F)(F)F)cc3)C[C@@H]2F)c1,J Med Chem,CHEMBL4216925,38,No,4.420216403
CHEMBL4195808,Inhibition of human ERG by fluorescence polarization assay,CC(C)(O)COc1ccc(C(N)=O)c(O[C@@H]2CCN(C(=O)Cc3ccc(OC(F)(F)F)cc3)C[C@@H]2F)c1,J Med Chem,CHEMBL4206532,38,No,4.420216403
CHEMBL4195808,Inhibition of human ERG by fluorescence polarization assay,CC(C)(O)COc1ccc(C(N)=O)c(O[C@H]2CCN(C(=O)Cc3ccc(OC(F)(F)F)cc3)C[C@H]2F)c1,J Med Chem,CHEMBL4203759,42,No,4.37675071
CHEMBL4195808,Inhibition of human ERG by fluorescence polarization assay,CC(C)(CO)Oc1ccc(C(N)=O)c(O[C@@H]2CCN(C(=O)Cc3ccc(OC(F)(F)F)cc3)C[C@@H]2F)c1,J Med Chem,CHEMBL4208638,35,No,4.455931956
CHEMBL4195809,Inhibition of human ERG by patch express assay,CNC(=O)c1cnc(N)c(O[C@H]2CN(C(=O)Cc3ccc(OC(F)(F)F)cc3)CC2(F)F)c1,J Med Chem,CHEMBL4207042,88,No,4.055517328
CHEMBL4199666,Inhibition of human ERG,Cc1ccc(Cc2cc3c(=O)n([C@H]4CCCC[C@@H]4O)cnc3c3ccccc23)cn1,ACS Med Chem Lett,CHEMBL4078588,60,No,4.22184875
CHEMBL4200746,Displacement of [3H]dofetilide from human ERG by high throughput assay,O=C(Nc1ccc(OC(F)(F)F)cc1)c1ccc(OCCN2CCCC2)c(-c2cncnc2)c1,J Med Chem,CHEMBL3908521,0.009,Yes,8.045757491
CHEMBL4200746,Displacement of [3H]dofetilide from human ERG by high throughput assay,CN1CCN(c2ncc(C(=O)Nc3ccc(OC(F)(F)F)cc3)cc2-c2cncnc2)CC1,J Med Chem,CHEMBL3910823,0.31,Yes,6.508638306
CHEMBL4220823,Inhibition of human ERG expressed in HEK293 cells by automated patch clamp method,CN(c1ncnc2[nH]ccc12)[C@@H]1CCN(C(=O)CC#N)C1,Bioorg Med Chem,CHEMBL4224807,93,No,4.031517051
CHEMBL4220823,Inhibition of human ERG expressed in HEK293 cells by automated patch clamp method,O=C(Nc1nc2cccc(-c3ccc(CN4CCS(=O)(=O)CC4)cc3)n2n1)C1CC1,Bioorg Med Chem,CHEMBL3301607,85,No,4.070581074
CHEMBL4221368,Inhibition of human ERG by patch clamp assay,COc1cc2ccc(Br)cc2cc1[C@@H](c1ccccc1)[C@@](O)(CCN(C)C)c1cccc2ccoc12,Bioorg Med Chem,CHEMBL4224771,0.8,Yes,6.096910013
CHEMBL4221368,Inhibition of human ERG by patch clamp assay,COc1cc2ccc(C#N)cc2cc1[C@@H](c1cccc(F)c1)[C@@](O)(CCN(C)C)c1cccc2ccoc12,Bioorg Med Chem,CHEMBL4229114,0.6,Yes,6.22184875
CHEMBL4221368,Inhibition of human ERG by patch clamp assay,COc1cc2ccc(Br)cc2cc1[C@@H](c1ccnc(OC)c1OC)[C@@](O)(CCN(C)C)c1cccc2ccoc12,Bioorg Med Chem,CHEMBL4228130,0.9,Yes,6.045757491
CHEMBL4221368,Inhibition of human ERG by patch clamp assay,COc1cc2ccc(Br)cc2cc1[C@@H](c1ccccc1)[C@@](O)(CCN(C)C)c1ccc2occc2c1,Bioorg Med Chem,CHEMBL4226478,0.4,Yes,6.397940009
CHEMBL4221368,Inhibition of human ERG by patch clamp assay,COc1cc2ccc(Br)cc2cc1[C@@H](c1ccnc(OC)c1OC)[C@@](O)(CCN(C)C)c1ccc2occc2c1,Bioorg Med Chem,CHEMBL4226743,0.6,Yes,6.22184875
CHEMBL4221368,Inhibition of human ERG by patch clamp assay,COc1cc2ccc(C#N)cc2cc1[C@@H](c1cccc(F)c1)[C@@](O)(CCN(C)C)c1cc2ccccc2o1,Bioorg Med Chem,CHEMBL4227540,0.9,Yes,6.045757491
CHEMBL4221368,Inhibition of human ERG by patch clamp assay,COc1cc2ccc(Br)cc2cc1[C@@H](c1ccnc(OC)c1OC)[C@@](O)(CCN(C)C)c1cc2ccccc2o1,Bioorg Med Chem,CHEMBL4226688,0.8,Yes,6.096910013
CHEMBL4221368,Inhibition of human ERG by patch clamp assay,COc1cc2ccc(Br)cc2cc1[C@@H](c1cccc(C)c1)[C@@](O)(CCN(C)C)c1cccc2c1OCO2,Bioorg Med Chem,CHEMBL4225434,0.5,Yes,6.301029996
CHEMBL4221368,Inhibition of human ERG by patch clamp assay,COc1cc2ccc(C#N)cc2cc1[C@@H](c1cccc(C)c1)[C@@](O)(CCN(C)C)c1cccc2c1OCO2,Bioorg Med Chem,CHEMBL4228918,0.3,Yes,6.522878745
CHEMBL4221371,Inhibition of human ERG assessed as prolongation of QT interval,COc1nc2ccc(Br)cc2cc1[C@@H](c1ccccc1)[C@@](O)(CCN(C)C)c1cccc2ccccc12,Bioorg Med Chem,CHEMBL376488,0.37,Yes,6.431798276
CHEMBL4222828,Inhibition of human ERG,Cc1cc(NCc2c(F)cccc2C(F)(F)F)c2cccc(C(N)=O)c2n1,Bioorg Med Chem,CHEMBL3604734,0.39811,Yes,6.399996913
CHEMBL4223976,Inhibition of human ERG,Fc1ccccc1-c1nc2ccn(Cc3ccc(-c4ccc(C(F)(F)F)cc4C(F)(F)F)nn3)cc-2n1,Bioorg Med Chem,CHEMBL1957287,0.79433,Yes,6.099999035
CHEMBL4224584,Inhibition of human ERG expressed in CHOK1 cells by patch clamp assay,COc1cc(N)c(Cl)cc1C(=O)N[C@@H]1CCN(CCCOc2ccc(F)cc2)C[C@@H]1OC,Bioorg Med Chem Lett,CHEMBL560739,0.012,Yes,7.920818754
CHEMBL4224584,Inhibition of human ERG expressed in CHOK1 cells by patch clamp assay,COc1ccc2nccc(CCN3CCC(NCc4ccc5c(c4)OCCO5)CC3)c2c1,Bioorg Med Chem Lett,CHEMBL4228387,0.81,Yes,6.091514981
CHEMBL4224584,Inhibition of human ERG expressed in CHOK1 cells by patch clamp assay,COc1ccc2nccc(CC[C@H]3CC[C@H](NCc4ccc5c(n4)NC(=O)CO5)CC3)c2c1,Bioorg Med Chem Lett,CHEMBL4228129,0.41,Yes,6.387216143
CHEMBL4224584,Inhibition of human ERG expressed in CHOK1 cells by patch clamp assay,COc1ccc2nccc(CC[C@H]3CC[C@H](NCc4cc5c(cn4)OCCO5)CC3)c2c1,Bioorg Med Chem Lett,CHEMBL4225277,0.94,Yes,6.026872146
CHEMBL4224584,Inhibition of human ERG expressed in CHOK1 cells by patch clamp assay,COc1ccc2nccc(CC[C@H]3CC[C@H](NCc4ccc5c(c4)OCCO5)CC3)c2c1,Bioorg Med Chem Lett,CHEMBL4228889,0.26,Yes,6.585026652
CHEMBL4236905,Inhibition of human ERG expressed in HEK293 cells by Barracuda automated patch clamp assay,Cc1ccn(-c2cccc([C@H](CC(=O)O)CN3CC[C@@H](CCc4ccc5c(n4)NCCC5)C3)c2)n1,J Med Chem,CHEMBL4247149,39.81072,No,4.399999968
CHEMBL4236905,Inhibition of human ERG expressed in HEK293 cells by Barracuda automated patch clamp assay,Cc1cc(C)n(-c2cccc([C@H](CC(=O)O)CN3CC[C@@H](CCc4ccc5c(n4)NCCC5)C3)c2)n1,J Med Chem,CHEMBL4241824,31.62278,No,4.499999953
CHEMBL4236905,Inhibition of human ERG expressed in HEK293 cells by Barracuda automated patch clamp assay,Cc1cnn(C)c1-c1cccc([C@H](CC(=O)O)CN2CC[C@@H](CCc3ccc4c(n3)NCCC4)C2)c1,J Med Chem,CHEMBL4250148,31.62278,No,4.499999953
CHEMBL4236905,Inhibition of human ERG expressed in HEK293 cells by Barracuda automated patch clamp assay,O=C(O)C[C@H](CN1CC[C@@H](CCc2ccc3c(n2)NCCC3)C1)c1cccc(O[C@H]2CCOC2)c1,J Med Chem,CHEMBL4249172,31.62278,No,4.499999953
CHEMBL4236905,Inhibition of human ERG expressed in HEK293 cells by Barracuda automated patch clamp assay,O=C(O)C[C@H](CN1CC[C@@H](CCc2ccc3c(n2)NCCC3)C1)c1cccc(O[C@@H]2CCOC2)c1,J Med Chem,CHEMBL4239085,39.81072,No,4.399999968
CHEMBL4236905,Inhibition of human ERG expressed in HEK293 cells by Barracuda automated patch clamp assay,O=C(O)C[C@H](CN1CC[C@@H](CCc2ccc3c(n2)NCCC3)C1)c1cccc(C2CCOC2)c1,J Med Chem,CHEMBL4244784,39.81072,No,4.399999968
CHEMBL4236905,Inhibition of human ERG expressed in HEK293 cells by Barracuda automated patch clamp assay,O=C(O)C[C@H](CN1CC[C@@H](CCc2ccc3c(n2)NCCC3)C1)c1cccc(C2CCOC2)c1,J Med Chem,CHEMBL4244784,39.81072,No,4.399999968
CHEMBL4236906,Inhibition of human ERG expressed in HEK293 cells by Q-patch assay,O=C(O)C[C@H](CN1CC[C@@H](CCc2ccc3c(n2)NCCC3)C1)c1cccc(-n2cccn2)c1,J Med Chem,CHEMBL4251444,0.79433,Yes,6.099999035
CHEMBL4236906,Inhibition of human ERG expressed in HEK293 cells by Q-patch assay,O=C(O)C[C@H](CN1CC[C@@H](CCc2ccc3c(n2)NCCC3)C1)c1cccc(O[C@@H]2CCOC2)c1,J Med Chem,CHEMBL4239085,31.62278,No,4.499999953
CHEMBL4236906,Inhibition of human ERG expressed in HEK293 cells by Q-patch assay,O=C(O)C[C@H](CN1CC[C@@H](CCc2ccc3c(n2)NCCC3)C1)c1cccc(C2CCOC2)c1,J Med Chem,CHEMBL4244784,31.62278,No,4.499999953
CHEMBL4255046,Inhibition of human ERG by [3H]dofetilide binding displacement assay,Cc1c(CN2CCOCC2)cc(-c2ccc(C(C)C)cc2)n1C1CCCCC1,Eur J Med Chem,CHEMBL4282585,50,No,4.301029996
CHEMBL4258485,Inhibition of human ERG expressed in HEK293 cells after 5 mins by automated planar patch clamp method,CN(c1ncnc2[nH]ccc12)[C@H]1CN(C(=O)CC#N)CC12CC2,Medchemcomm,CHEMBL4279819,120,No,3.920818754
CHEMBL4258485,Inhibition of human ERG expressed in HEK293 cells after 5 mins by automated planar patch clamp method,O=C(Nc1nc2cccc(-c3ccc(CN4CCS(=O)(=O)CC4)cc3)n2n1)C1CC1,Medchemcomm,CHEMBL3301607,85,No,4.070581074
CHEMBL4260925,Displacement of [3H]-dofetilide from human ERG expressed in CHO cell membranes after 90 mins by micro-beta counting,CN(c1ccc(-c2cc3ccccc3s2)nn1)C1CC(C)(C)NC(C)(C)C1,J Med Chem,CHEMBL4281315,0.11,Yes,6.958607315
CHEMBL4260925,Displacement of [3H]-dofetilide from human ERG expressed in CHO cell membranes after 90 mins by micro-beta counting,CC1(C)CC(Nc2ccc(-c3cc4ccccc4s3)nn2)CC(C)(C)N1,J Med Chem,CHEMBL4289183,0.6,Yes,6.22184875
CHEMBL4260925,Displacement of [3H]-dofetilide from human ERG expressed in CHO cell membranes after 90 mins by micro-beta counting,CN(c1ccc(-c2cc3ccccc3cc2O)nn1)C1CC(C)(C)NC(C)(C)C1,J Med Chem,CHEMBL4292990,0.08,Yes,7.096910013
CHEMBL4260925,Displacement of [3H]-dofetilide from human ERG expressed in CHO cell membranes after 90 mins by micro-beta counting,CN(c1ccc(-c2ccc(C#N)cc2O)nn1)C1CC(C)(C)NC(C)(C)C1,J Med Chem,CHEMBL4283397,0.3,Yes,6.522878745
CHEMBL4260925,Displacement of [3H]-dofetilide from human ERG expressed in CHO cell membranes after 90 mins by micro-beta counting,CN(c1ccc(-c2ccc(-n3cccn3)cc2O)nn1)C1CC(C)(C)NC(C)(C)C1,J Med Chem,CHEMBL4280558,0.3,Yes,6.522878745
CHEMBL4260925,Displacement of [3H]-dofetilide from human ERG expressed in CHO cell membranes after 90 mins by micro-beta counting,CC1(C)CC(Oc2ccc(-c3ccc(-n4cccn4)cc3O)nn2)CC(C)(C)N1,J Med Chem,CHEMBL4288439,0.23,Yes,6.638272164
CHEMBL4260925,Displacement of [3H]-dofetilide from human ERG expressed in CHO cell membranes after 90 mins by micro-beta counting,Oc1cc(-c2cn[nH]c2)ccc1-c1ccc(N2CCC3(CCCNC3)C2)nn1,J Med Chem,CHEMBL4294614,0.27,Yes,6.568636236
CHEMBL4262602,Inhibition of human ERG expressed in HEK293 cells at -80 mV holding potential by PatchXpress automated electrophysiology method,NC1=N[C@@]2(CO1)c1cc(NC(=O)c3ccc(Cl)cn3)ccc1Oc1cnc(C3=CCCOC3)cc12,Medchemcomm,CHEMBL4294221,0.9,Yes,6.045757491
CHEMBL4264023,Inhibition of human ERG,C=CC(=O)N[C@H]1CCN(c2ccc(C(N)=O)c(Nc3ccc(N4CCCCC4)nc3)n2)C1,Bioorg Med Chem Lett,CHEMBL4278717,0.26,Yes,6.585026652
CHEMBL4266935,Displacement of 3H-dofetilide from human ERG,CCCCNc1nc(N)nc2c1CN(C(=O)c1cccs1)CC2,Bioorg Med Chem Lett,CHEMBL4281089,0.9,Yes,6.045757491
CHEMBL4269690,Inhibition of human ERG by whole cell electrophysiology analysis,C[C@@H]1COCCN1c1cc(C2(S(C)(=O)=O)CC2)nc(-c2cccc3[nH]ccc23)n1,J Med Chem,CHEMBL2325697,50,No,4.301029996
CHEMBL4269690,Inhibition of human ERG by whole cell electrophysiology analysis,C[C@@H]1COCCN1c1cc(C2([S@](C)(=N)=O)CC2)nc(-c2cc[nH]c3nccc2-3)n1,J Med Chem,CHEMBL4285417,166,No,3.779891912
CHEMBL4270242,Inhibition of MK-499 binding to human ERG,CCOc1cc(CN2CCC(c3ncc(-c4ccc(F)cc4)[nH]3)CC2)cc(OCC)c1-c1ccc(F)cc1,ACS Med Chem Lett,CHEMBL4288417,0.26,Yes,6.585026652
CHEMBL4270242,Inhibition of MK-499 binding to human ERG,CCOc1cc(CN2CCC3(CC2)CCN(S(=O)(=O)c2cccnc2)CC3)cc(OCC)c1-c1ccc(F)cc1,ACS Med Chem Lett,CHEMBL4280531,0.21,Yes,6.677780705
CHEMBL4270242,Inhibition of MK-499 binding to human ERG,CCOc1cc(CN2CCC(C3CCN(S(=O)(=O)c4ccccc4)CC3)CC2)cc(OCC)c1-c1ccc(F)cc1,ACS Med Chem Lett,CHEMBL4278161,0.22,Yes,6.657577319
CHEMBL4270242,Inhibition of MK-499 binding to human ERG,CCOc1cc(CN2CCC(COc3cccc4cccnc34)CC2)cc(OCC)c1-c1ccc(F)cc1,ACS Med Chem Lett,CHEMBL4288848,0.21,Yes,6.677780705
CHEMBL4270242,Inhibition of MK-499 binding to human ERG,CCOc1cc(CN2CCC3(CC2)CC(Cc2ccc(F)cc2)C(=O)O3)cc(OCC)c1-c1ccc(F)cc1,ACS Med Chem Lett,CHEMBL4292255,0.95,Yes,6.022276395
CHEMBL4270242,Inhibition of MK-499 binding to human ERG,CCOc1cc(CN2CCC3(CC2)CC(=O)N(c2ccc(C(=O)O)cc2)C3)cc(OCC)c1-c1ccc(F)cc1.O=C(O)C(F)(F)F,ACS Med Chem Lett,CHEMBL4282052,45,No,4.346787486
CHEMBL4275131,Inhibition of human ERG expressed in CHOK1 cells assessed as reduction in tail current at -80 holding potential after 100 to 200 secs by whole cell automated patch-clamp electrophysiology assay,O=C1S/C(=C\c2ccc(Oc3ccc([N+](=O)[O-])cc3)cc2)C(=O)N1c1ccc(OCCCCN2CCN(CC3CC3)CC2)cc1,Eur J Med Chem,CHEMBL4279795,55.3,No,4.257274869
CHEMBL4276588,Inhibition of human ERG expressed in HEK293 cells at -50 mV holding potential by patch clamp assay,Cc1nc2n(c(=O)c1CCN1CCC(c3noc4cc(F)ccc34)CC1)CCCC2,J Med Chem,CHEMBL85,0.1671,Yes,6.77702355
CHEMBL4276588,Inhibition of human ERG expressed in HEK293 cells at -50 mV holding potential by patch clamp assay,O=C(CCCN1CCC(c2noc3cc(F)ccc23)CC1)c1cc2c3c(c1)CCN3C(=O)CC2,J Med Chem,CHEMBL4289498,0.8237,Yes,6.084230934
CHEMBL4305236,Inhibition of human ERG expressed in CHOK1 cells by Q-patch electrophysiology method,Cc1ccc(-c2cc(S(=O)(=O)c3ccc(CN)s3)ccc2S(C)(=O)=O)cc1.Cl,J Med Chem,CHEMBL4434955,68,No,4.167491087
CHEMBL4308576,Inhibition of human ERG,CC(C)c1ccc(-c2cc(CN3CCOCC3)nn2C2CCC2)cc1,ACS Med Chem Lett,CHEMBL4476297,32,No,4.494850022
CHEMBL4310146,Inhibition of human ERG by patch clamp electrophysiology,FC(F)(F)c1cccc(Nc2cc3[nH]c(Nc4ccc(N5CCOCC5)cn4)nc3cn2)c1,J Med Chem,CHEMBL4545990,0.5,Yes,6.301029996
CHEMBL4312823,Displacement of Tracer Red from human ERG by fluorescence polarization assay,Nc1n[nH]c(N2CCC(N3CCOC[C@@H]3Cc3ccc(Cl)cc3)CC2)n1,J Med Chem,CHEMBL4461925,39,No,4.408935393
CHEMBL4312823,Displacement of Tracer Red from human ERG by fluorescence polarization assay,Nc1n[nH]c(N2CCC(N3C[C@H](O)C[C@@H]3Cc3ccc(Cl)cc3)CC2)n1,J Med Chem,CHEMBL4547227,55,No,4.259637311
CHEMBL4312823,Displacement of Tracer Red from human ERG by fluorescence polarization assay,CO[C@H]1CN(C2CCN(c3nc(N)n[nH]3)CC2)[C@H]1Cc1ccc(Cl)cc1,J Med Chem,CHEMBL4466293,0.34,Yes,6.468521083
CHEMBL4313152,Inhibition of human ERG by patch-clamp method,Cc1ccc2oc(-c3c4c(N)n[nH]c(=O)c4nn3-c3ccc(NC(=O)/C=C/CN(C)C)cc3)c(C)c2c1,J Med Chem,CHEMBL4463714,32.85,No,4.483464626
CHEMBL4313152,Inhibition of human ERG by patch-clamp method,Cc1c(C(=O)CC#N)oc2ccccc12,J Med Chem,CHEMBL4537540,0.03,Yes,7.522878745
CHEMBL4313152,Inhibition of human ERG by patch-clamp method,Cc1ccc2oc(C(=O)CC#N)c(C)c2c1,J Med Chem,CHEMBL4577458,0.03,Yes,7.522878745
CHEMBL4313152,Inhibition of human ERG by patch-clamp method,Cc1c(C(=O)CC#N)oc2ccc(Cl)cc12,J Med Chem,CHEMBL4443436,0.03,Yes,7.522878745
CHEMBL4313152,Inhibition of human ERG by patch-clamp method,Cc1c(C(=O)CC#N)oc2ccc(Br)cc12,J Med Chem,CHEMBL4592743,0.03,Yes,7.522878745
CHEMBL4313394,Inhibition of human ERG incubated for 4 hrs by competitive fluorescence tracer binding based assay,Cc1cccc(CCN2CCC(C(=O)c3ccc(NS(C)(=O)=O)cc3)CC2)n1,Eur J Med Chem,CHEMBL327980,0.021,Yes,7.677780705
CHEMBL4315950,Inhibition of human ERG,O=C(c1cn(CCCNCc2ccc(Oc3ccc(Cl)cc3)cc2)nn1)N1CCOCC1,Eur J Med Chem,CHEMBL4440009,0.678,Yes,6.168770306
CHEMBL4315950,Inhibition of human ERG,CCCCOc1ccc(Cl)c(OCCCC)c1/N=N/c1c(O)ccc2ccccc12,Eur J Med Chem,CHEMBL4444525,0.38,Yes,6.420216403
CHEMBL4315950,Inhibition of human ERG,CCCCOc1cc(Cl)cc(OCCCC)c1/N=N/c1c(O)ccc2ccccc12,Eur J Med Chem,CHEMBL4469841,0.4,Yes,6.397940009
CHEMBL4315950,Inhibition of human ERG,CCCCOc1cc(Cl)c(/N=N/c2c(O)ccc3ccccc23)c(OCCCC)c1,Eur J Med Chem,CHEMBL4451572,0.4,Yes,6.397940009
CHEMBL4315950,Inhibition of human ERG,O=C(CCNC(=O)c1cccc([N+](=O)[O-])c1)NC1CCOC1=O,Eur J Med Chem,CHEMBL4579589,904.35,No,3.043663457
CHEMBL4315950,Inhibition of human ERG,O=C(CCNC(=O)c1cccc([N+](=O)[O-])c1)Nc1nc(=O)[nH]cc1F,Eur J Med Chem,CHEMBL4517913,356.18,No,3.44833047
CHEMBL4315950,Inhibition of human ERG,O=C(CCCS(=O)(=O)c1ccccc1)NC1CCOC1=O,Eur J Med Chem,CHEMBL4586478,109.01,No,3.96253366
CHEMBL4315950,Inhibition of human ERG,O=C(CCCS(=O)(=O)c1ccccc1)Nc1cc[nH]c(=O)n1,Eur J Med Chem,CHEMBL4520260,67.8,No,4.168770306
CHEMBL4315950,Inhibition of human ERG,O=C(CCCS(=O)(=O)c1ccccc1)Nc1nc(=O)[nH]cc1F,Eur J Med Chem,CHEMBL4445189,40.477,No,4.392791683
CHEMBL4316969,Inhibition of human ERG expressed in CHO cells in at -80 mV holding potential by automated Qpatch clamp assay,COc1cc(N)c(Cl)cc1C(=O)N[C@H]1CCN(CCCOc2ccc(F)cc2)C[C@H]1OC,J Med Chem,CHEMBL74656,0.19,Yes,6.721246399
CHEMBL4322077,Inhibition of human ERG,O=C1OCCc2cc([C@@H]3CN4CCN(C(=O)Cc5ccc(-n6cnnn6)cc5)C[C@H]4CO3)ccc21,J Med Chem,CHEMBL3987135,75.9,No,4.119758224
CHEMBL4326143,Inhibition of human ERG expressed in CHO cells at holding potential of -90 mV by QPatch clamp method,CCN(CC)Cc1cc(-c2ccc3ncc(-c4ccc([S+](C)[O-])cc4)n3n2)ccc1F,Medchemcomm,CHEMBL4483664,0.59,Yes,6.229147988
CHEMBL4326143,Inhibition of human ERG expressed in CHO cells at holding potential of -90 mV by QPatch clamp method,C[S+]([O-])c1ccc(Nc2ccc3ncc(-c4ccc([S+](C)[O-])cc4)n3n2)cc1,Medchemcomm,CHEMBL4443635,32.3,No,4.490797478
CHEMBL4331782,Inhibition of human ERG,CC(C)(C)c1ccc2[nH]c(C(C)(C)N)nc2c1,Bioorg Med Chem,CHEMBL4466809,41,No,4.387216143
CHEMBL4331822,Inhibition of human ERG after 4 hrs by fluorescence polarization assay,Cl.O=S(=O)(/C=C/c1ncccc1F)c1ccc(OCCCN2CCOCC2)cc1,J Med Chem,CHEMBL4465428,112.1,No,3.950394387
CHEMBL4332217,Inhibition of human ERG by patch clamp method,CS(=O)(=O)c1cc(C2(NC(=O)c3cncc4c3cnn4-c3ccc(F)cc3)CC2)ccn1,Bioorg Med Chem Lett,CHEMBL4456123,68,No,4.167491087
CHEMBL4340978,Inhibition of human ERG incubated for 1 hr by Fluorescence polarization binding assay,CN1CCC(CNc2ccc3ncc(-c4cccc(OC(F)(F)F)c4)n3n2)CC1,Eur J Med Chem,CHEMBL1952329,0.511,Yes,6.2915791
CHEMBL4342657,Inhibition of human ERG expressed in CHO cells at holding potential of -80 mV by patch clamp method,C[C@H]1C[C@H]2CSC(N)=N[C@@]2(c2cc(NC(=O)c3ccc(OC(F)F)cn3)ccc2F)CO1,Bioorg Med Chem Lett,CHEMBL4483673,0.4,Yes,6.397940009
CHEMBL4354044,Inhibition of human ERG,O=C1OCCN1CCNc1nonc1/C(=N/O)Nc1ccc(F)c(Br)c1,Eur J Med Chem,CHEMBL4443777,31.12,No,4.506960412
CHEMBL4356657,Inhibition of human ERG expressed in CHOK1 cells assessed as reduction in channel current at -80 mV holding potential by whole cell patch clamp assay,CC1OC2(CCN(CCc3ccccc3)CC2)CN(c2ccccc2)C1=O,J Med Chem,CHEMBL4541206,0.4,Yes,6.397940009
CHEMBL4356657,Inhibition of human ERG expressed in CHOK1 cells assessed as reduction in channel current at -80 mV holding potential by whole cell patch clamp assay,C[C@@H]1OC2(CCN(CCc3ccccc3)CC2)CN(c2ccccc2)C1=O,J Med Chem,CHEMBL4467749,0.3,Yes,6.522878745
CHEMBL4356657,Inhibition of human ERG expressed in CHOK1 cells assessed as reduction in channel current at -80 mV holding potential by whole cell patch clamp assay,CCC1OC2(CCN(CCc3ccccc3)CC2)CN(c2ccccc2)C1=O,J Med Chem,CHEMBL4515812,0.4,Yes,6.397940009
CHEMBL4356657,Inhibition of human ERG expressed in CHOK1 cells assessed as reduction in channel current at -80 mV holding potential by whole cell patch clamp assay,O=C1C(COCc2ccccc2)OC2(CCN(CCc3ccccc3)CC2)CN1c1ccccc1,J Med Chem,CHEMBL4528962,0.1,Yes,7
CHEMBL4356657,Inhibition of human ERG expressed in CHOK1 cells assessed as reduction in channel current at -80 mV holding potential by whole cell patch clamp assay,COC(=O)CC1OC2(CCN(CCc3ccccc3)CC2)CN(c2ccccc2)C1=O,J Med Chem,CHEMBL4446209,0.2,Yes,6.698970004
CHEMBL4356657,Inhibition of human ERG expressed in CHOK1 cells assessed as reduction in channel current at -80 mV holding potential by whole cell patch clamp assay,CC1(C)OC2(CCN(CCc3ccccc3)CC2)CN(c2ccccc2)C1=O,J Med Chem,CHEMBL4516327,0.1,Yes,7
CHEMBL4356657,Inhibition of human ERG expressed in CHOK1 cells assessed as reduction in channel current at -80 mV holding potential by whole cell patch clamp assay,CC1OC2(CCN(CCc3ccccc3)CC2)CN(c2cnccn2)C1=O,J Med Chem,CHEMBL4439718,0.1,Yes,7
CHEMBL4356657,Inhibition of human ERG expressed in CHOK1 cells assessed as reduction in channel current at -80 mV holding potential by whole cell patch clamp assay,CC1OC2(CCN(CCc3ccccc3)CC2)CN(c2cncc(C(F)(F)F)c2)C1=O,J Med Chem,CHEMBL4593220,0.5,Yes,6.301029996
CHEMBL4356657,Inhibition of human ERG expressed in CHOK1 cells assessed as reduction in channel current at -80 mV holding potential by whole cell patch clamp assay,CC1OC2(CCN(CCc3ccccc3F)CC2)CN(c2ccccc2)C1=O,J Med Chem,CHEMBL4536259,0.8,Yes,6.096910013
CHEMBL4356657,Inhibition of human ERG expressed in CHOK1 cells assessed as reduction in channel current at -80 mV holding potential by whole cell patch clamp assay,CC1OC2(CCN(CCc3cccc(F)c3)CC2)CN(c2ccccc2)C1=O,J Med Chem,CHEMBL4534193,0.6,Yes,6.22184875
CHEMBL4356657,Inhibition of human ERG expressed in CHOK1 cells assessed as reduction in channel current at -80 mV holding potential by whole cell patch clamp assay,CC1OC2(CCN(CCc3ccc(F)cc3)CC2)CN(c2ccccc2)C1=O,J Med Chem,CHEMBL4544352,0.1,Yes,7
CHEMBL4356657,Inhibition of human ERG expressed in CHOK1 cells assessed as reduction in channel current at -80 mV holding potential by whole cell patch clamp assay,CC1OC2(CCN(CCc3cccc(C#N)c3)CC2)CN(c2ccccc2)C1=O,J Med Chem,CHEMBL4463621,0.6,Yes,6.22184875
CHEMBL4358500,Inhibition of dofetilide binding to flag-tagged human ERG,C=CC(=O)N1CCC[C@H]1COc1c(N)ncnc1-c1cc(F)cc(NC(=O)c2ccc(C3CC3)cc2F)c1C,J Med Chem,CHEMBL4537231,0.049,Yes,7.30980392
CHEMBL4359448,Inhibition of human ERG expressed in HEK293 cells by whole cell electrophysiology assay,Cc1cc(/C=C/C#N)cc(C)c1Oc1nc(NC2CCN(Cc3ccc(S(N)(=O)=O)cc3)CC2)nc2sccc12,J Med Chem,CHEMBL4526732,0.979,Yes,6.009217308
CHEMBL4359448,Inhibition of human ERG expressed in HEK293 cells by whole cell electrophysiology assay,Cc1cc(/C=C/C#N)cc(C)c1Oc1nc(NC2CCN(Cc3ccc(S(N)(=O)=O)cc3)CC2)nc2ccsc12,J Med Chem,CHEMBL4094163,0.186,Yes,6.730487056
CHEMBL4359448,Inhibition of human ERG expressed in HEK293 cells by whole cell electrophysiology assay,Cc1cc(/C=C/C#N)cc(C)c1Nc1ccnc(Nc2ccc(C#N)cc2)n1,J Med Chem,CHEMBL175691,0.5,Yes,6.301029996
CHEMBL4359448,Inhibition of human ERG expressed in HEK293 cells by whole cell electrophysiology assay,Cc1cc(C#N)cc(C)c1Oc1nc(NC2CCN(Cc3ccc(S(N)(=O)=O)cc3)CC2)nc2ccsc12,J Med Chem,CHEMBL3929927,0.13,Yes,6.886056648
CHEMBL4359465,Inhibition of human ERG expressed in HEK293 cells by patch clamp assay,Cc1cccc(CCN2CCC(C(=O)c3ccc(NS(C)(=O)=O)cc3)CC2)n1,J Med Chem,CHEMBL327980,0.027,Yes,7.568636236
CHEMBL4362471,Inhibition of human ERG transfected in HEK293 cells by whole-cell patch clamp method,CON=C1CCC(CN2CCN(c3nc(=O)c4cc(C(F)(F)F)cc([N+](=O)[O-])c4s3)CC2)CC1,Eur J Med Chem,CHEMBL4475126,47.98,No,4.318939756
CHEMBL4362471,Inhibition of human ERG transfected in HEK293 cells by whole-cell patch clamp method,CCON=C1CCC(CN2CCN(c3nc(=O)c4cc(C(F)(F)F)cc([N+](=O)[O-])c4s3)CC2)CC1,Eur J Med Chem,CHEMBL4571987,38.92,No,4.409827168
CHEMBL4362471,Inhibition of human ERG transfected in HEK293 cells by whole-cell patch clamp method,O=c1nc(N2CCN(CC3CCCCC3)CC2)sc2c([N+](=O)[O-])cc(C(F)(F)F)cc12,Eur J Med Chem,CHEMBL3330226,101.7,No,3.992679047
CHEMBL4366089,Inhibition of human ERG expressed in HEK293 cells by whole cell patch clamp method,CC(C)NC(C(=O)N[C@](Cc1ccccc1)(c1ccc(F)cc1)c1cc(F)cc(C(F)(F)F)c1)C(O)(C(F)(F)F)C(F)(F)F,ACS Med Chem Lett,CHEMBL4452514,63,No,4.200659451
CHEMBL4366089,Inhibition of human ERG expressed in HEK293 cells by whole cell patch clamp method,CC(C)Oc1cc([C@@](Cc2ccccc2)(NC(=O)C(N)C(O)(C(F)(F)F)C(F)(F)F)c2cc(F)cc(OC(F)(F)C(F)F)c2)ccc1F,ACS Med Chem Lett,CHEMBL4457286,44,No,4.356547324
CHEMBL4370144,Inhibition of human ERG expressed in HEK293 cells at -80 mV holding potential by manual patch clamp assay,Cc1cc(C#N)cc(C)c1Oc1nc(NC2CCN(Cc3ccc(C(N)=O)cc3)CC2)nc2c1COC2,J Med Chem,CHEMBL4514678,0.83,Yes,6.080921908
CHEMBL4370144,Inhibition of human ERG expressed in HEK293 cells at -80 mV holding potential by manual patch clamp assay,CC(C)(C)c1ccc(C(O)CCCN2CCC(C(O)(c3ccccc3)c3ccccc3)CC2)cc1,J Med Chem,CHEMBL17157,0.086,Yes,7.065501549
CHEMBL4373005,Inhibition of human ERG,COCCC#Cc1c(Cl)c2c(Cl)cc(C(N)=O)nc2n1[C@H]1CCCNC1,Bioorg Med Chem Lett,CHEMBL4540910,0.003,Yes,8.522878745
CHEMBL4373005,Inhibition of human ERG,COCC(C)(C)C#Cc1c(Cl)c2c(Cl)cc(C(N)=O)nc2n1[C@H]1CCCNC1,Bioorg Med Chem Lett,CHEMBL4457529,0.0011,Yes,8.958607315
CHEMBL4373005,Inhibition of human ERG,COC(C)(C)CC#Cc1c(Cl)c2c(Cl)cc(C(N)=O)nc2n1[C@H]1CCCNC1,Bioorg Med Chem Lett,CHEMBL4541837,0.004,Yes,8.397940009
CHEMBL4373005,Inhibition of human ERG,NC(=O)c1cc(Cl)c2c(Cl)c(C#CC3CCCO3)n([C@H]3CCCNC3)c2n1,Bioorg Med Chem Lett,CHEMBL4518492,0.005,Yes,8.301029996
CHEMBL4373005,Inhibition of human ERG,NC(=O)c1cc(Cl)c2c(Cl)c(C#CC3CCCO3)n([C@H]3CCCNC3)c2n1,Bioorg Med Chem Lett,CHEMBL4518492,0.01,Yes,8
CHEMBL4373005,Inhibition of human ERG,NC(=O)c1cc(Cl)c2c(Cl)c(C#CC3CCOCC3)n([C@H]3CCCNC3)c2n1,Bioorg Med Chem Lett,CHEMBL4528544,0.0017,Yes,8.769551079
CHEMBL4373005,Inhibition of human ERG,NC(=O)c1cc(Cl)c2c(Cl)c(C#CC3COCCO3)n([C@H]3CCCNC3)c2n1,Bioorg Med Chem Lett,CHEMBL4466764,0.0014,Yes,8.853871964
CHEMBL4373005,Inhibition of human ERG,CC1(C#Cc2c(Cl)c3c(Cl)cc(C(N)=O)nc3n2[C@H]2CCCNC2)COC1,Bioorg Med Chem Lett,CHEMBL4470576,0.003,Yes,8.522878745
CHEMBL4373005,Inhibition of human ERG,CC1(CC#Cc2c(Cl)c3c(Cl)cc(C(N)=O)nc3n2[C@H]2CCCNC2)COC1,Bioorg Med Chem Lett,CHEMBL4457389,0.005,Yes,8.301029996
CHEMBL4373005,Inhibition of human ERG,CC(C)(C#N)CC#Cc1c(Cl)c2c(Cl)cc(C(N)=O)nc2n1[C@H]1CCCNC1,Bioorg Med Chem Lett,CHEMBL4445116,0.003,Yes,8.522878745
CHEMBL4373005,Inhibition of human ERG,NC(=O)c1cc(Cl)c2c(Cl)c(C#CC3CNCCO3)n([C@H]3CCCNC3)c2n1,Bioorg Med Chem Lett,CHEMBL4583118,0.006,Yes,8.22184875
CHEMBL4373140,Inhibition of human ERG expressed in CHO cells assessed as reduction in peak channel current by IonWork patch-clamp electrophysiology method,COc1ccc(CCN(C)CCCC(C#N)(c2ccc(OC)c(OC)c2)C(C)C)cc1OC.Cl,J Med Chem,CHEMBL1280,0.2,Yes,6.698970004
CHEMBL4375019,Inhibition of human ERG,O=c1ccc2ncc(=O)n3c2n1C[C@H]3CN1CCC(NCc2cc3c(cn2)OCCC3)CC1,J Med Chem,CHEMBL3317856,1400,No,2.853871964
CHEMBL4377385,Inhibition of human ERG by in vitro patch clamp method,CNC(=O)c1cnc(Nc2cc(C)c(F)cn2)cc1Nc1cccc(-c2ncn(C)n2)c1OC,J Med Chem,CHEMBL4557190,38,No,4.420216403
CHEMBL4381375,Inhibition of human ERG,Cc1cc(/C=C/C#N)cc(C)c1Nc1ccnc(Nc2ccc(C#N)cc2)n1,J Med Chem,CHEMBL175691,0.5,Yes,6.301029996
CHEMBL4381402,Inhibition of human ERG expressed in HEK293 cells assessed as reduction in channel tail current by whole cell patch clamp assay,Cc1cc(C#N)cc(C)c1Oc1nc(NC2CCN(Cc3ccc(S(N)(=O)=O)cc3)CC2)nc2ccsc12,J Med Chem,CHEMBL3929927,0.13,Yes,6.886056648
CHEMBL4381402,Inhibition of human ERG expressed in HEK293 cells assessed as reduction in channel tail current by whole cell patch clamp assay,Cc1cc(/C=C/C#N)cc(C)c1Oc1nc(Nc2ccc(C#N)cc2F)nc2sccc12,J Med Chem,CHEMBL4520763,0.18,Yes,6.744727495
CHEMBL4383328,Displacement of [3H]-Dofetilide from recombinant human ERG after 60 mins by scintillation counting analysis,O=C(NNC(=S)Nc1ccc(Cl)c(Cl)c1)c1ccccc1O,Eur J Med Chem,CHEMBL4476621,0.08,Yes,7.096910013
CHEMBL4383858,Inhibition of red tracer binding to human ERG expressed in membranes preincubated for 10 to 15 mins followed by tracer addition measured after 3 hrs by fluorescence polarization assay,Cc1cccc(CCN2CCC(C(=O)c3ccc(NS(C)(=O)=O)cc3)CC2)n1.Cl.Cl,Eur J Med Chem,CHEMBL536480,0.01,Yes,8
CHEMBL4384705,Inhibition of human ERG expressed in CHO-K1 cells by Patch clamp assay,CC1(c2ccc(NS(C)(=O)=O)cc2)NC(=O)N(CC(=O)c2ccc(F)cc2F)C1=O,J Med Chem,CHEMBL4534405,39.81072,No,4.399999968
CHEMBL4392036,Inhibition of Tracer Red binding to human ERG expressed in membranes by fluorescence polarization assay,C[C@H](NC(=O)[C@H]1CNC[C@@H]1c1ccc(C(F)(F)F)cc1)c1ccc(N(C)C)cc1,J Med Chem,CHEMBL4436020,32,No,4.494850022
CHEMBL4393244,Inhibition of human ERG by whole-cell patch clamp method,CC(C)c1cc(C(=O)NC[C@H]2CCN(CCc3ccc(C(F)(F)F)cc3)C2)on1,Bioorg Med Chem Lett,CHEMBL4467412,0.41,Yes,6.387216143
CHEMBL4393244,Inhibition of human ERG by whole-cell patch clamp method,CC(C)c1cc(C(=O)NC[C@H]2CCN(CCc3ccc(OC(F)(F)F)c(F)c3)C2)on1,Bioorg Med Chem Lett,CHEMBL4574825,0.16,Yes,6.795880017
CHEMBL4393244,Inhibition of human ERG by whole-cell patch clamp method,COC(=O)C1=C(C)NC(C)=C(C(=O)NC[C@H]2CCN(CCc3ccc(Cl)c(Cl)c3)C2)C1c1cccc([N+](=O)[O-])c1,Bioorg Med Chem Lett,CHEMBL4459378,0.65,Yes,6.187086643
CHEMBL4393244,Inhibition of human ERG by whole-cell patch clamp method,COC(=O)C1=C(C)NC(C)=C(C(=O)NC[C@H]2CCN(CCc3ccc(Cl)c(F)c3)C2)C1c1cccc([N+](=O)[O-])c1,Bioorg Med Chem Lett,CHEMBL4555422,0.33,Yes,6.48148606
CHEMBL4395516,Inhibition of fluorescently labeled tracer binding to human ERG by competitive binding assay,Cc1cccc(CCN2CCC(C(=O)c3ccc(NS(C)(=O)=O)cc3)CC2)n1,Eur J Med Chem,CHEMBL327980,0.00782,Yes,8.106793247
CHEMBL4396291,Inhibition of human ERG expressed in CHO cells at -80 mV holding potential by automated patch clamp electrophysiology assay,COc1ccc2c(c1)CCN(CCC(F)Cc1ccccc1)CC2,Eur J Med Chem,CHEMBL4457961,0.553,Yes,6.257274869
CHEMBL4396793,Inhibition of human ERG in HEK293 cells assessed as effect on QT interval,CC(C)C[C@H](NC(=O)[C@H](CCc1ccccc1)NC(=O)CN1CCOCC1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CC(C)C)C(=O)[C@@]1(C)CO1,Bioorg Med Chem,CHEMBL451887,92.1,No,4.03574037
CHEMBL4397934,Inhibition of human ERG expressed in CHO cells at -80 mV holding potential measured after 3 mins by QPatch automated patch-clamp assay,COc1cc(N)c(Cl)cc1C(=O)N[C@H]1CCN(CCCOc2ccc(F)cc2)C[C@H]1OC,J Med Chem,CHEMBL74656,0.07,Yes,7.15490196
CHEMBL4399583,Inhibition of human ERG,Cc1cc(-c2ccnc3[nH]nc(C(F)(F)F)c23)cc(C2(CN)CCC2)c1,ACS Med Chem Lett,CHEMBL4590477,0.7,Yes,6.15490196
CHEMBL4400294,Inhibition of human ERG,C[C@H]1CCCN1CCCOc1ccc2c(c1)CC[C@H]1[C@@H]3[C@H](C(=O)N4CCCC4)CC(=O)[C@@]3(C)CC[C@H]21,Bioorg Med Chem Lett,CHEMBL4474244,80,No,4.096910013
CHEMBL4403243,Inhibition of human ERG expressed in CHOK1 cells by Qpatch electrophysiological assay,NCc1ncc(S(=O)(=O)c2ccc3ccccc3c2)s1,J Med Chem,CHEMBL4457629,51,No,4.292429824
CHEMBL4403243,Inhibition of human ERG expressed in CHOK1 cells by Qpatch electrophysiological assay,CCc1cc(-c2ccccc2)cc(S(=O)(=O)c2cnc(CN)s2)c1,J Med Chem,CHEMBL4564074,36,No,4.443697499
CHEMBL4403243,Inhibition of human ERG expressed in CHOK1 cells by Qpatch electrophysiological assay,CCc1cc(-c2cnn(C)c2)cc(S(=O)(=O)c2cnc(CN)s2)c1,J Med Chem,CHEMBL4444163,47,No,4.327902142
CHEMBL4403243,Inhibition of human ERG expressed in CHOK1 cells by Qpatch electrophysiological assay,Cn1cc(-c2cc(F)cc(S(=O)(=O)c3cnc(CN)s3)c2)cn1,J Med Chem,CHEMBL4460845,66,No,4.180456064
CHEMBL4409081,Inhibition of human ERG expressed in HEK293 cells incubated for 72 hrs by patch clamp assay,Cc1cc(C(N)=O)c(-c2cccc(OC(=O)NCCN3CCN(c4ccccc4)CC3)c2)s1,Eur J Med Chem,CHEMBL4565200,0.28,Yes,6.552841969
CHEMBL4409081,Inhibition of human ERG expressed in HEK293 cells incubated for 72 hrs by patch clamp assay,Cc1cc(C(N)=O)c(-c2cccc(OC(=O)NCCN3CCN(c4ccccc4)CC3)c2)s1,Eur J Med Chem,CHEMBL4565200,0.28184,Yes,6.54999737
CHEMBL4410390,Inhibition of ERG in human HEK293 cells incubated for 1 hr by thallium flux assay,O=C1c2ccccc2C(Cc2ccnc(F)c2)(Cc2ccnc(F)c2)c2ccccc21,Bioorg Med Chem Lett,CHEMBL343822,32,No,4.494850022
CHEMBL4410921,Inhibition of human ERG expressed in HEK293 cells by voltage patch clamp assay,CCOc1c([C@H](C)n2nc(C)c3c(N)ncnc32)cc(Cl)c(F)c1[C@@H]1CNC(=O)C1,ACS Med Chem Lett,CHEMBL4297615,75,No,4.124938737
CHEMBL4414124,Inhibition of human ERG by Q-patch assay,Cn1c(N2CCC(C)(N)CC2)nc2[nH]nc(-c3cccc(Cl)c3Cl)c2c1=O,J Med Chem,CHEMBL4469071,0.2,Yes,6.698970004
CHEMBL4414124,Inhibition of human ERG by Q-patch assay,Cn1c(N2CCC(C)(CN)CC2)nc2[nH]nc(-c3cccc(Cl)c3Cl)c2c1=O,J Med Chem,CHEMBL4539145,0.98,Yes,6.008773924
CHEMBL4414124,Inhibition of human ERG by Q-patch assay,Cn1c(N2CCC3(CCC[C@H]3N)CC2)nc2[nH]nc(-c3cccc(Cl)c3Cl)c2c1=O,J Med Chem,CHEMBL4437876,0.25,Yes,6.602059991
CHEMBL4414124,Inhibition of human ERG by Q-patch assay,Cn1c(N2CCC3(CC2)COC[C@H]3N)nc2[nH]nc(-c3cccc(Cl)c3Cl)c2c1=O,J Med Chem,CHEMBL4459445,0.93,Yes,6.031517051
CHEMBL4414124,Inhibition of human ERG by Q-patch assay,C[C@@H]1OCC2(CCN(c3nc4[nH]nc(-c5cccc(Cl)c5Cl)c4c(=O)n3C)CC2)[C@@H]1N,J Med Chem,CHEMBL4455446,0.29,Yes,6.537602002
CHEMBL4414124,Inhibition of human ERG by Q-patch assay,C[C@@H]1OCC2(CCN(c3cnc4c(-c5cccc(Cl)c5Cl)n[nH]c4n3)CC2)[C@@H]1N,J Med Chem,CHEMBL4475043,0.004,Yes,8.397940009
CHEMBL4414124,Inhibition of human ERG by Q-patch assay,C[C@@H]1OCC2(CCN(c3cnc4c(-c5cccc(Cl)c5Cl)c[nH]c4n3)CC2)[C@@H]1N,J Med Chem,CHEMBL4475081,0.007,Yes,8.15490196
CHEMBL4414831,Inhibition of human ERG by fluorescence polarization assay,CNC(=O)c1cnc(Nc2ccc(N3CCOCC3)cn2)cc1Nc1ccccc1S(C)(=O)=O,J Med Chem,CHEMBL4472802,40,No,4.397940009
CHEMBL4414831,Inhibition of human ERG by fluorescence polarization assay,CNC(=O)c1cnc(Nc2ccc(C)nn2)cc1Nc1ccccc1S(C)(=O)=O,J Med Chem,CHEMBL4453545,43,No,4.366531544
CHEMBL4414831,Inhibition of human ERG by fluorescence polarization assay,CNC(=O)c1cnc(Nc2ccccn2)cc1Nc1ccccc1S(C)(=O)=O,J Med Chem,CHEMBL4544320,36,No,4.443697499
CHEMBL4416173,Inhibition of human ERG expressed in CHO cells by Q-patch clamp assay,Nc1nc(-c2ccc(F)cc2)c(-c2ccnc(Nc3ccc(N4CCNCC4)cc3)n2)s1,J Med Chem,CHEMBL4459320,35.5,No,4.449771647
CHEMBL4416173,Inhibition of human ERG expressed in CHO cells by Q-patch clamp assay,CC(=O)Nc1nc(-c2ccc(F)cc2)c(-c2ccnc(Nc3ccc(N4CCNCC4)cc3)n2)s1,J Med Chem,CHEMBL4451783,38,No,4.420216403
CHEMBL4416173,Inhibition of human ERG expressed in CHO cells by Q-patch clamp assay,CN1CCC(C(=O)Nc2nc(-c3ccc(F)cc3)c(-c3ccnc(Nc4ccc(N5CCNCC5)cc4)n3)s2)CC1,J Med Chem,CHEMBL4459919,50.1,No,4.300162274
CHEMBL4416173,Inhibition of human ERG expressed in CHO cells by Q-patch clamp assay,Fc1ccc(-c2nc(C3CCNCC3)sc2-c2ccnc(Nc3ccncn3)n2)cc1,J Med Chem,CHEMBL4572065,0.6,Yes,6.22184875
CHEMBL4424285,Inhibition of human ERG expressed in HEK293 cells at 10 uM by Qpatch clamp assay,CCc1cc(F)c2nc(N3CCC(NC4CCOCC4)CC3)c(-c3nc(C)no3)c(C)c2c1,J Med Chem,CHEMBL4592045,0.001,Yes,9
CHEMBL4427468,Displacement of [35S]MK-499 from human ERG,Cc1c([C@H](O)CN2CCN(C[C@H](O)c3ccc4c(c3C)COC4=O)CC2)ccc2c1COC2=O,ACS Med Chem Lett,CHEMBL3696477,100,No,4
CHEMBL4427468,Displacement of [35S]MK-499 from human ERG,Cc1c([C@H](O)CN2CCN(C[C@@H](O)c3ccc4c(c3C)COC4=O)CC2)ccc2c1COC2=O,ACS Med Chem Lett,CHEMBL3696476,47,No,4.327902142
CHEMBL4427468,Displacement of [35S]MK-499 from human ERG,Cc1c(C(F)CN2CCN(CC(F)c3ccc4c(c3C)COC4=O)CC2)ccc2c1COC2=O,ACS Med Chem Lett,CHEMBL4573466,40,No,4.397940009
CHEMBL4427468,Displacement of [35S]MK-499 from human ERG,O=[N+]([O-])c1ccc(CCN2CCN(CCc3ccc([N+](=O)[O-])cc3)CC2)cc1,ACS Med Chem Lett,CHEMBL2146755,0.007,Yes,8.15490196
CHEMBL4427468,Displacement of [35S]MK-499 from human ERG,Cc1c(C(F)CN2CCN(C(=O)Cc3ccc(-n4cnnn4)cc3)CC2)ccc2c1COC2=O,ACS Med Chem Lett,CHEMBL4566857,68,No,4.167491087
CHEMBL4427468,Displacement of [35S]MK-499 from human ERG,Cc1c(C(O)CN2CCN(C(=O)Cc3ccc(-n4cnnn4)cc3)CC2)ccc2c1COC2=O,ACS Med Chem Lett,CHEMBL4438583,100,No,4
CHEMBL4427468,Displacement of [35S]MK-499 from human ERG,Cc1c(C(C)CN2CCN(C(=O)Cc3ccc(-n4cnnn4)cc3)CC2)ccc2c1COC2=O,ACS Med Chem Lett,CHEMBL4522413,60,No,4.22184875
CHEMBL4427809,Displacement of [3H]-dofetilide from human ERG expressed in HEK293 cells measured after 90 mins by scintillation proximity assay,NCc1ccc(C(=O)N2C[C@@H](n3cc(C4CC4)nn3)C[C@H]2C(=O)NCC(c2ccccc2)c2ccccc2)cc1,Bioorg Med Chem Lett,CHEMBL4448473,0.5,Yes,6.301029996
CHEMBL4427858,Inhibition of MK499 binding to human ERG,Cn1cc(NC(=O)c2cccc(-c3ccnc(NCC4CC4)c3)n2)c(C(=O)N2CC(CN)C2)n1,Bioorg Med Chem Lett,CHEMBL4434908,40,No,4.397940009
CHEMBL4429529,Inhibition of human ERG expressed in CHO-K1 cells after 10 mins by Rb efflux assay,N#Cc1ccc(N2CCC(Nc3cc(Nc4ccccn4)ncc3C(N)=O)CC2)nc1,Bioorg Med Chem,CHEMBL4455068,0.36,Yes,6.443697499
CHEMBL4431791,Inhibition of human ERG,CCOc1ccc2cc(-c3nn(CC4CCN(C)CC4)c4ncnc(N)c34)ccc2c1,J Med Chem,CHEMBL2078876,0.4,Yes,6.397940009
CHEMBL4431791,Inhibition of human ERG,CCOc1ccc2cc(-c3nn(CC4CCN(C(C)C)CC4)c4ncnc(N)c34)ccc2c1,J Med Chem,CHEMBL4445679,0.3,Yes,6.522878745
CHEMBL4431791,Inhibition of human ERG,CN1CCC(Cn2nc(-c3ccc4cc(OCC5CC5)ccc4c3)c3c(N)ncnc32)CC1,J Med Chem,CHEMBL4572930,0.9,Yes,6.045757491
CHEMBL4431791,Inhibition of human ERG,CN1CCC(Cn2nc(-c3ccc4cc(OC5CCC5)ccc4c3)c3c(N)ncnc32)CC1,J Med Chem,CHEMBL4444685,0.2,Yes,6.698970004
CHEMBL4431791,Inhibition of human ERG,CN1CCC(Cn2nc(-c3ccc4cc(OC5CC5)ccc4c3)c3c(N)ncnc32)CC1,J Med Chem,CHEMBL4543259,0.37,Yes,6.431798276
CHEMBL4431791,Inhibition of human ERG,CN1CCC(Cn2nc(-c3ccc4nc(OCC(F)(F)F)ccc4c3)c3c(N)ncnc32)CC1,J Med Chem,CHEMBL4450160,0.5,Yes,6.301029996
CHEMBL4431791,Inhibition of human ERG,CN(C)CC(C)(C)Cn1nc(-c2ccc3nc(OC4CC4)ccc3c2)c2c(N)ncnc21,J Med Chem,CHEMBL4443394,0.082,Yes,7.086186148
CHEMBL4432005,Inhibition of human ERG in membranes incubated for 2 hrs by fluorescence polarization assay,O=c1c(O)c(-c2cccc(O)c2)oc2ccc(O)cc12,J Med Chem,CHEMBL4464764,99.3,No,4.003050752
CHEMBL4432076,Inhibition of human ERG channel,CC(C)=CCn1c(N2CCC[C@H](N)C2)nc2c1c(=O)n(CC(=O)c1ccccc1)c(=O)n2C,J Med Chem,CHEMBL237067,0.2,Yes,6.698970004
CHEMBL4432866,Inhibition of human ERG expressed in HEK293 cells by whole cell patch clamp assay,CCNC(=O)Nc1ccc(-c2nc(N3CCOC[C@@H]3C)c3c(n2)C(C)(C)S(=O)(=O)C3)cc1,ACS Med Chem Lett,CHEMBL4577549,48,No,4.318758763
CHEMBL4433046,Inhibition of human ERG expressed in CHOK1 cell membranes after 2 hrs by cy3b-dofetilide-based fluorescence polarization assay,CN(C)c1ccc(-c2cc3nccnc3c(NCCCCN)n2)cn1,Bioorg Med Chem Lett,CHEMBL4437415,39.81072,No,4.399999968
CHEMBL4433046,Inhibition of human ERG expressed in CHOK1 cell membranes after 2 hrs by cy3b-dofetilide-based fluorescence polarization assay,CN(C)c1ccc(-c2cc3nccnc3c(NCCCCO)n2)cn1,Bioorg Med Chem Lett,CHEMBL4439653,31.62278,No,4.499999953
CHEMBL4433046,Inhibition of human ERG expressed in CHOK1 cell membranes after 2 hrs by cy3b-dofetilide-based fluorescence polarization assay,CN(C)c1ccc(-c2cc(NC[C@H]3CCCNC3)c3cccnc3c2)cn1,Bioorg Med Chem Lett,CHEMBL4472827,39.81072,No,4.399999968
CHEMBL4433046,Inhibition of human ERG expressed in CHOK1 cell membranes after 2 hrs by cy3b-dofetilide-based fluorescence polarization assay,O=C1CN(c2cc3nccnc3c(NC[C@H]3CCCNC3)n2)CCN1,Bioorg Med Chem Lett,CHEMBL4436508,50.11872,No,4.300000029
CHEMBL4433285,Inhibition of human ERG expressed in CHO cells at holding potential of -90 mV by patch clamp method,COc1ccc(CCN(C)CCCC(C#N)(c2ccc(OC)c(OC)c2)C(C)C)cc1OC,Bioorg Med Chem,CHEMBL6966,0.53,Yes,6.27572413
CHEMBL4478172,Inhibition of human ERG by electrophysiology assay,CCC(CC)CNc1c(C(N)=O)cnc2ccc(-c3cccnc3)cc12,J Med Chem,CHEMBL4543897,0.67,Yes,6.173925197
CHEMBL4478172,Inhibition of human ERG by electrophysiology assay,NC(=O)c1cnc2ccc(-c3cccnc3)cc2c1NC1CCCC1,J Med Chem,CHEMBL4578468,0.57,Yes,6.244125144
CHEMBL4478172,Inhibition of human ERG by electrophysiology assay,NC(=O)c1cnc2ccc(-c3cccnc3)cc2c1NCC1CCCCC1,J Med Chem,CHEMBL4550293,0.83,Yes,6.080921908
CHEMBL4478172,Inhibition of human ERG by electrophysiology assay,CCC(CC)CNc1c(C(N)=O)cnc2ccc(-c3ccncc3)cc12,J Med Chem,CHEMBL4569880,0.62,Yes,6.207608311
CHEMBL4478172,Inhibition of human ERG by electrophysiology assay,CCC(CC)CNc1c(C(N)=O)cnc2ccc(-c3cncnc3)cc12,J Med Chem,CHEMBL4585489,0.76,Yes,6.119186408
CHEMBL4478172,Inhibition of human ERG by electrophysiology assay,CCC(CC)CNc1c(C(N)=O)c(C)nc2ccc(-c3cccnc3)cc12,J Med Chem,CHEMBL4574647,0.68,Yes,6.167491087
CHEMBL4478172,Inhibition of human ERG by electrophysiology assay,CCC(CC)CNc1c(C(N)=O)cnc2c(C)cc(-c3cccnc3)cc12,J Med Chem,CHEMBL4543599,0.36,Yes,6.443697499
CHEMBL4481698,Inhibition of human ERG by manual patch clamp electrophysiology assay,COc1cccc(C(O)(CCN(C)C)C(c2cc3cc(Br)ccc3nc2OC)c2cccc3c2OCO3)n1,Bioorg Med Chem,CHEMBL4563167,0.24,Yes,6.619788758
CHEMBL4481698,Inhibition of human ERG by manual patch clamp electrophysiology assay,COc1nc2ccc(Br)cc2cc1C(c1cccc(C)c1)C(O)(CCN(C)C)c1cccnc1OC,Bioorg Med Chem,CHEMBL4535649,0.45,Yes,6.346787486
CHEMBL4481698,Inhibition of human ERG by manual patch clamp electrophysiology assay,COc1nc2ccc(C#N)cc2cc1C(c1cccc(C)c1)C(O)(CCN(C)C)c1cccnc1OC,Bioorg Med Chem,CHEMBL4575859,0.3,Yes,6.522878745
CHEMBL4604972,Displacement of [3H]dofetilide from human ERG expressed in CHO cells incubated for 90 mins by microbeta scintillation counting method,Nc1cc(-c2cn(-c3ccccc3)c3cnccc23)ccn1,J Med Chem,CHEMBL4640465,0.59,Yes,6.229147988
CHEMBL4604972,Displacement of [3H]dofetilide from human ERG expressed in CHO cells incubated for 90 mins by microbeta scintillation counting method,O=C(Nc1cc(-c2cn(-c3ccccc3)c3cnccc23)ccn1)C1CC1,J Med Chem,CHEMBL4648047,0.13,Yes,6.886056648
CHEMBL4605025,Inhibition of human ERG by Qpatch S8 assay,O=C(Nc1cc(-c2cn(-c3ccccc3)c3cnccc23)ccn1)NC1CC1,J Med Chem,CHEMBL4645474,0.6,Yes,6.22184875
CHEMBL4605649,Inhibition of human ERG incubated for 4 hrs by competitive fluorescence tracer binding based assay,COCCN1CCN(Cc2ccc(NC(=O)c3ccc(C)c(C#Cc4cnc5cccnn45)c3)cc2C2CC2)CC1,ACS Med Chem Lett,CHEMBL4637502,0.08,Yes,7.096910013
CHEMBL4605649,Inhibition of human ERG incubated for 4 hrs by competitive fluorescence tracer binding based assay,Cc1ccc(C(=O)Nc2ccc(CN3CCN(CCO)CC3)c(Cl)c2)cc1C#Cc1cnc2cccnn12,ACS Med Chem Lett,CHEMBL4642144,0.1,Yes,7
CHEMBL4605649,Inhibition of human ERG incubated for 4 hrs by competitive fluorescence tracer binding based assay,Cc1ccc(C(=O)Nc2ccc(CN3CCN(CCO)CC3)c(C3CC3)c2)cc1C#Cc1cnc2cccnn12,ACS Med Chem Lett,CHEMBL4632471,0.34,Yes,6.468521083
CHEMBL4605649,Inhibition of human ERG incubated for 4 hrs by competitive fluorescence tracer binding based assay,Cc1ccc(C(=O)Nc2ccc(CN3Cc4ccc(O)cc4C3)c(Cl)c2)cc1C#Cc1cnc2cccnn12,ACS Med Chem Lett,CHEMBL4633367,0.78,Yes,6.107905397
CHEMBL4605649,Inhibition of human ERG incubated for 4 hrs by competitive fluorescence tracer binding based assay,Cc1cn(-c2cc(NC(=O)c3ccc(C)c(Nc4nccc(-c5cccnc5)n4)c3)cc(C(F)(F)F)c2)cn1,ACS Med Chem Lett,CHEMBL255863,0.45,Yes,6.346787486
CHEMBL4605649,Inhibition of human ERG incubated for 4 hrs by competitive fluorescence tracer binding based assay,Cc1ccc(C(=O)Nc2ccc(CN3CCN(C)CC3)c(C(F)(F)F)c2)cc1C#Cc1cnc2cccnn12,ACS Med Chem Lett,CHEMBL1171837,0.77,Yes,6.113509275
CHEMBL4605859,Inhibition of human ERG expressed in human embryonic kidney cells by manual patch clamp assay,COc1ccc(-c2cnn3c(N)c(-c4ccccc4)c(NC4CC(C)(C)N(C)C(C)(C)C4)nc23)cc1OC,ACS Med Chem Lett,CHEMBL4644274,0.5,Yes,6.301029996
CHEMBL4605958,Inhibition of human ERG,Cc1cc(Cl)cc(-c2ccnc3cc(CN4C(=O)C5C(C4=O)C5(C)C)sc23)c1O[C@@H]1CCNC[C@@H]1C,J Med Chem,CHEMBL4635160,0.4,Yes,6.397940009
CHEMBL4606240,Inhibition of human ERG,COc1ccc(CCN(C)CCCC(C#N)(c2ccc(OC)c(OC)c2)C(C)C)cc1OC,J Med Chem,CHEMBL6966,0.4,Yes,6.397940009
CHEMBL4606403,Inhibition of human ERG expressed in HEK293 cells measured after 30 mins by FluxOR dye based FLIPR TETRA assay,O=C(CCCCCCC(=O)Nc1ccccc1)NOC(c1ccccc1)(c1ccccc1)c1ccccc1,J Med Chem,CHEMBL4640366,96.22,No,4.016734647
CHEMBL4612554,Inhibition of human ERG stably expressed in HEK293 cells,CN(CCOc1ccc(NS(C)(=O)=O)cc1)CCc1ccc(NS(C)(=O)=O)cc1,J Med Chem,CHEMBL473,0.015,Yes,7.823908741
CHEMBL4614017,Inhibition of human ERG,CC(O)CN1[C@H](C)CN(CCSC(c2ccc(F)cc2)c2ccc(F)cc2)C[C@@H]1C,J Med Chem,CHEMBL4636778,0.635,Yes,6.197226275
CHEMBL4614017,Inhibition of human ERG,C[C@@H]1CN(CC[S+]([O-])C(c2ccc(F)cc2)c2ccc(F)cc2)C[C@H](C)N1CC(O)Cc1ccccc1,J Med Chem,CHEMBL4639814,0.0915,Yes,7.038578906
CHEMBL4615929,Inhibition of human ERG expressed in CHOK1 cells assessed as reduction in tail current by measuring tail current amplitude measured after deploarization to +20 mV for 2s followed by 1s pulse to -40 mV by whole cell patch clamp assay,COCCN1CCC(CNC(=O)c2n[nH]c3ccc(-c4cccc(F)c4F)cc23)CC1,ACS Med Chem Lett,CHEMBL3735506,0.044,Yes,7.356547324
CHEMBL4615929,Inhibition of human ERG expressed in CHOK1 cells assessed as reduction in tail current by measuring tail current amplitude measured after deploarization to +20 mV for 2s followed by 1s pulse to -40 mV by whole cell patch clamp assay,O=C(NCC1CCOCC1)c1n[nH]c2ccc(-c3cccnc3)cc12,ACS Med Chem Lett,CHEMBL4638321,49.3,No,4.307153081
CHEMBL4615929,Inhibition of human ERG expressed in CHOK1 cells assessed as reduction in tail current by measuring tail current amplitude measured after deploarization to +20 mV for 2s followed by 1s pulse to -40 mV by whole cell patch clamp assay,CC(C)Oc1cncc(-c2ccc3[nH]nc(C(=O)NCC4CCOCC4)c3c2)c1,ACS Med Chem Lett,CHEMBL4632807,0.86,Yes,6.065501549
CHEMBL4615929,Inhibition of human ERG expressed in CHOK1 cells assessed as reduction in tail current by measuring tail current amplitude measured after deploarization to +20 mV for 2s followed by 1s pulse to -40 mV by whole cell patch clamp assay,COCc1ccncc1-c1ccc2[nH]nc(C(=O)NCC3CCOCC3)c2c1,ACS Med Chem Lett,CHEMBL4636306,47.1,No,4.326979093
CHEMBL4615929,Inhibition of human ERG expressed in CHOK1 cells assessed as reduction in tail current by measuring tail current amplitude measured after deploarization to +20 mV for 2s followed by 1s pulse to -40 mV by whole cell patch clamp assay,O=C(NCC1CCOCC1)c1n[nH]c2ccc(-c3cnccc3CO)cc12,ACS Med Chem Lett,CHEMBL4641148,41.3,No,4.384049948
CHEMBL4619017,Displacement of Tracer Red from human ERG by fluorescence polarization assay,Nc1nc(N2CCC(N(CCc3ccc(Cl)cc3)Cc3ccccc3O)CC2)n[nH]1,ACS Med Chem Lett,CHEMBL4637417,0.1,Yes,7
CHEMBL4619017,Displacement of Tracer Red from human ERG by fluorescence polarization assay,Nc1nc(N2CCC(N(CCc3ccc(Cl)cc3)Cc3cccc(O)c3)CC2)n[nH]1,ACS Med Chem Lett,CHEMBL4634943,0.15,Yes,6.823908741
CHEMBL4619017,Displacement of Tracer Red from human ERG by fluorescence polarization assay,Nc1nc(N2CCC(N(CCc3ccc(Cl)cc3)Cc3ccc(Cl)cc3)CC2)n[nH]1,ACS Med Chem Lett,CHEMBL4646309,0.4,Yes,6.397940009
CHEMBL4619017,Displacement of Tracer Red from human ERG by fluorescence polarization assay,Nc1nc(N2CCC(N3Cc4ccncc4OC[C@@H]3Cc3ccc(Cl)cc3)CC2)n[nH]1,ACS Med Chem Lett,CHEMBL4648162,50,No,4.301029996
CHEMBL4619017,Displacement of Tracer Red from human ERG by fluorescence polarization assay,CN1C[C@H](Cc2ccc(Cl)cc2)N(C2CCN(c3n[nH]c(N)n3)CC2)Cc2cc(Cl)ccc21,ACS Med Chem Lett,CHEMBL4643001,0.8,Yes,6.096910013
CHEMBL4619106,Inhibition of human ERG,COc1cc(N2C[C@H]3CC[C@@H](C2)[C@@H]3Nc2nc3n(n2)CCCCC3c2ccc(F)c(F)c2F)ncn1,ACS Med Chem Lett,CHEMBL4647524,0.55,Yes,6.259637311
CHEMBL4619106,Inhibition of human ERG,Cc1cc(N2C[C@H]3CC[C@@H](C2)[C@@H]3Nc2nc3n(n2)CCCN3c2cc(F)cc(F)c2)ncn1,ACS Med Chem Lett,CHEMBL4645821,0.7,Yes,6.15490196
CHEMBL4619543,Inhibition of human ERG expressed in HEK293 cells measured after 10 mins by manual patch clamp electrophysiology method,Cc1c(N2CC[C@@H]([C@H](C)N)C2)c(F)cc2ccc(=O)n(C3CC3)c12,J Med Chem,CHEMBL4640061,48.8,No,4.311580178
CHEMBL4619551,Inhibition of human ERG expressed in CHOK1 cells measured for 10 mins by QPatch automated patch-clamp assay,Cc1c(N2CC3CC3(N)C2)c(F)cc2c(CN)c(F)c(=O)n(C3CC3)c12,J Med Chem,CHEMBL4634552,114,No,3.943095149
CHEMBL4623822,Inhibition of human ERG by Ionworks high-throughput electrophysiology method,Cn1nccc1[C@H]1CCCC[C@@H]1Oc1cc(F)c(S(=O)(=O)Nc2cscn2)cc1F,J Med Chem,CHEMBL4635030,94,No,4.026872146
CHEMBL4623822,Inhibition of human ERG by Ionworks high-throughput electrophysiology method,Cc1cc(S(=O)(=O)Nc2ccncn2)c(F)cc1O[C@H]1CCCC[C@@H]1c1ccnn1C,J Med Chem,CHEMBL4639987,90,No,4.045757491
CHEMBL4627218,Inhibition of human ERG,NC(=O)[C@@H]1CCC[C@H](c2ccc(OCc3cccc(F)c3)cc2)N1,ACS Med Chem Lett,CHEMBL4637074,31.62278,No,4.499999953
CHEMBL4627218,Inhibition of human ERG,CN1[C@@H](c2ccc(OCc3ccccc3F)cc2)CC[C@H]1C(N)=O,ACS Med Chem Lett,CHEMBL4633318,50.11872,No,4.300000029
CHEMBL4627218,Inhibition of human ERG,NC(=O)[C@@H]1CC[C@H](c2cccc(Oc3ccccc3)c2)N1,ACS Med Chem Lett,CHEMBL4646990,63.09573,No,4.200000031
CHEMBL4669217,Inhibition of human ERG,Cc1nn(-c2ccnc3[nH]c(-c4cccc5c4ccn5C)nc23)cc1CN1CC[C@@H](O)C1,Bioorg Med Chem Lett,CHEMBL4791746,31,No,4.508638306
CHEMBL4669424,Inhibition of human ERG expressed in HEK293 cells,Cc1cc(Cl)cc(N2C=Nc3cc(C)c(-c4cc(O)cc(F)c4)cc3C2C(=O)N(C)C[C@@H]2CCCN2)c1,Bioorg Med Chem Lett,CHEMBL4750691,0.63096,Yes,6.199998172
CHEMBL4669424,Inhibition of human ERG expressed in HEK293 cells,Cc1cc(Cl)cc(N2C=Nc3cc(C)c(-c4cc(O)ccc4F)cc3C2C(=O)N(C)C[C@@H]2CCCN2)c1,Bioorg Med Chem Lett,CHEMBL4785112,0.50119,Yes,6.299997603
CHEMBL4671572,Inhibition of human ERG,Cc1ccc2c(c1)C(C1=C[C@H](C)N(C)CC1)=Nc1cc(Cl)ccc1N2,Bioorg Med Chem Lett,CHEMBL4745124,0.8,Yes,6.096910013
CHEMBL4671572,Inhibition of human ERG,CCOc1ccc2c(c1)C(C1=C[C@H](C)N(C)CC1)=Nc1cc(Cl)ccc1N2,Bioorg Med Chem Lett,CHEMBL4758966,0.9,Yes,6.045757491
CHEMBL4671572,Inhibition of human ERG,C[C@H]1C=C(C2=Nc3cc(Cl)ccc3Nc3ccc(Cl)cc32)CCN1C,Bioorg Med Chem Lett,CHEMBL4795230,0.9,Yes,6.045757491
CHEMBL4671572,Inhibition of human ERG,C[C@H]1C=C(C2=Nc3cc(Cl)ccc3Nc3ccc(C#N)cc32)CCN1C,Bioorg Med Chem Lett,CHEMBL4742056,0.6,Yes,6.22184875
CHEMBL4671572,Inhibition of human ERG,CCc1ccc2c(c1)C(C1=C[C@H](C)N(C)CC1)=Nc1ccccc1N2,Bioorg Med Chem Lett,CHEMBL4756987,0.6,Yes,6.22184875
CHEMBL4671572,Inhibition of human ERG,C[C@H]1C=C(C2=Nc3ccccc3Nc3ccc(Cl)cc32)CCN1C,Bioorg Med Chem Lett,CHEMBL4740880,0.6,Yes,6.22184875
CHEMBL4671732,Inhibition of human ERG,COC(=O)N(C)c1c(N)nc(-c2nc(Cc3ccccc3F)n3ccccc23)nc1N,Bioorg Med Chem Lett,CHEMBL4751262,0.4,Yes,6.397940009
CHEMBL4676425,Inhibition of human ERG expressed in CHO cells at -80 mV holding potential by whole cell patch clamp assay,CC1OC2(CCN(CCc3ccccc3)CC2)CN(CCc2ccccc2)C1=O,J Med Chem,CHEMBL4796605,0.2,Yes,6.698970004
CHEMBL4676425,Inhibition of human ERG expressed in CHO cells at -80 mV holding potential by whole cell patch clamp assay,CC1OC2(CCN(CCc3ccccc3)CC2)CN(Cc2ccccc2)C1=O,J Med Chem,CHEMBL4748898,0.1,Yes,7
CHEMBL4676425,Inhibition of human ERG expressed in CHO cells at -80 mV holding potential by whole cell patch clamp assay,CC1OC2(CCN(CCc3ccccc3)CC2)CN(c2ccccc2)C1=O,J Med Chem,CHEMBL4541206,0.4,Yes,6.397940009
CHEMBL4678145,Inhibition of human ERG,COc1cc(N)c(Cl)cc1C(=O)N[C@H]1CCN(CCCOc2ccc(F)cc2)C[C@H]1OC,Bioorg Med Chem Lett,CHEMBL74656,0.27,Yes,6.568636236
CHEMBL4681980,Inhibition of human ERG expressed in HEK293 cells,CC(C)(Oc1ccc(-c2cnc(N)c(-c3ccc(Cl)cc3)c2)cc1)C(=O)O,J Med Chem,CHEMBL4746566,100,No,4
CHEMBL4685428,Inhibition of human ERG expressed in CHO cells with 0 mV holding potential by Ionworks electrophysiology assay,Cc1cccc(CCN2CCC(C(=O)c3ccc(NS(C)(=O)=O)cc3)CC2)n1.Cl.Cl,Eur J Med Chem,CHEMBL536480,0.08913,Yes,7.049976093
CHEMBL4689504,Inhibition of human ERG,CC1(C)OC(=O)c2ccc(Nc3ncc(-c4nc(C56CCN(CC5)CC6)no4)c(N[C@H](CO)c4ccccc4)n3)cc21,ACS Med Chem Lett,CHEMBL4780798,0.57,Yes,6.244125144
CHEMBL4689681,Displacement of [35S]-MK499 binding to human ERG expressed in HEK293 cells incubated for 2 hrs by liquid scintillation counting method,CCCNC(=O)C1(c2ccc(NC(=O)c3cccc(Cl)c3)cc2)CCC1,ACS Med Chem Lett,CHEMBL4636709,60,No,4.22184875
CHEMBL4689681,Displacement of [35S]-MK499 binding to human ERG expressed in HEK293 cells incubated for 2 hrs by liquid scintillation counting method,COC(=O)N1CCCc2nc([C@@H](C)NC(=O)c3ccc(F)cc3)ccc21,ACS Med Chem Lett,CHEMBL4747995,60,No,4.22184875
CHEMBL4689681,Displacement of [35S]-MK499 binding to human ERG expressed in HEK293 cells incubated for 2 hrs by liquid scintillation counting method,CCOC(=O)N1CCCc2nc([C@@H](C)NC(=O)c3ccc(F)cc3)ccc21,ACS Med Chem Lett,CHEMBL4788473,60,No,4.22184875
CHEMBL4689681,Displacement of [35S]-MK499 binding to human ERG expressed in HEK293 cells incubated for 2 hrs by liquid scintillation counting method,C[C@@H](NC(=O)c1ccc(F)cc1)c1ccc2c(n1)CCCN2C(=O)OC1CCC1,ACS Med Chem Lett,CHEMBL4764710,60,No,4.22184875
CHEMBL4689681,Displacement of [35S]-MK499 binding to human ERG expressed in HEK293 cells incubated for 2 hrs by liquid scintillation counting method,Cc1cc(N2CCCc3nc([C@@H](C)NC(=O)c4ccc(F)cc4)ccc32)ccn1,ACS Med Chem Lett,CHEMBL4747474,0.73,Yes,6.13667714
CHEMBL4700475,Inhibition of human ERG,Cc1c(-c2cnc3[nH]ncc3c2)ccc2c3oc(CN)nc3c(=O)n(C3CC3)c12,RSC Med Chem,CHEMBL4787847,45.08,No,4.346016093
CHEMBL4700775,Inhibition of human ERG by patch clamp method,CNc1nc(Nc2ccc(-n3cnc(Cl)c3)c(OC)c2)nc2c1CC[C@H]2c1ccccc1,ACS Med Chem Lett,CHEMBL4794465,0.2,Yes,6.698970004
CHEMBL4703153,Inhibition of human ERG expressed in HEK293 cells by patch clamp assay,COc1nc(-c2csc(Nc3c4c(nn3C)CCC4)n2)ccc1-n1cnc(C)c1,Bioorg Med Chem,CHEMBL4741605,0.92,Yes,6.036212173
CHEMBL4703153,Inhibition of human ERG expressed in HEK293 cells by patch clamp assay,COc1nc(-c2csc(Nc3c4c(nn3CC(F)(F)F)CCC4)n2)ccc1-n1cnc(C)c1,Bioorg Med Chem,CHEMBL4777391,0.92,Yes,6.036212173
CHEMBL4704019,Inhibition of tracer red binding to human ERG expressed in HEK293 cell membranes measured after 2 to 6 hrs by fluorescence polarization assay,Nc1n[nH]c(N2CCC(N3CCOC[C@@H]3Cc3ccc(Cl)cc3)CC2)n1,J Med Chem,CHEMBL4461925,39,No,4.408935393
CHEMBL4704019,Inhibition of tracer red binding to human ERG expressed in HEK293 cell membranes measured after 2 to 6 hrs by fluorescence polarization assay,Nc1n[nH]c(N2CCC(N3CC(=O)NC[C@@H]3Cc3ccc(Cl)cc3)CC2)n1,J Med Chem,CHEMBL4758240,80,No,4.096910013
CHEMBL4704019,Inhibition of tracer red binding to human ERG expressed in HEK293 cell membranes measured after 2 to 6 hrs by fluorescence polarization assay,CC[C@H]1CN(C2CCN(c3nc(N)n[nH]3)CC2)[C@@H](Cc2ccc(Cl)cc2)CO1,J Med Chem,CHEMBL4776610,33,No,4.48148606
CHEMBL4704019,Inhibition of tracer red binding to human ERG expressed in HEK293 cell membranes measured after 2 to 6 hrs by fluorescence polarization assay,CC(C)[C@H]1CN(C2CCN(c3nc(N)n[nH]3)CC2)[C@@H](Cc2ccc(Cl)cc2)CO1,J Med Chem,CHEMBL4794014,34,No,4.468521083
CHEMBL4704019,Inhibition of tracer red binding to human ERG expressed in HEK293 cell membranes measured after 2 to 6 hrs by fluorescence polarization assay,Nc1n[nH]c(N2CCC(N3C[C@H](CO)OC[C@@H]3Cc3ccc(Cl)cc3)CC2)n1,J Med Chem,CHEMBL4789376,72,No,4.142667504
CHEMBL4704019,Inhibition of tracer red binding to human ERG expressed in HEK293 cell membranes measured after 2 to 6 hrs by fluorescence polarization assay,COC[C@H]1CN(C2CCN(c3nc(N)n[nH]3)CC2)[C@@H](Cc2ccc(Cl)cc2)CO1,J Med Chem,CHEMBL4755139,100,No,4
CHEMBL4704384,Inhibition of human ERG by patch clamp method,CN1CCCN(c2nccc3[nH]c(-c4ccc(F)c(F)c4)nc23)CC1,J Med Chem,CHEMBL4746185,0.4,Yes,6.397940009
CHEMBL4704384,Inhibition of human ERG by patch clamp method,CN1CCCN(c2nccc3[nH]c(-c4cc(F)cc(F)c4)nc23)CC1,J Med Chem,CHEMBL4758157,0.4,Yes,6.397940009
CHEMBL4706357,Inhibition of human ERG expressed in CHO cells at -40 mV holding potential by Q-patch clamp assay,O=C(N[C@H]1CCN(C2CCCCC2)C[C@@H]1C(=O)NCCc1ccccn1)c1cc(-c2ccc(F)cc2F)on1,J Med Chem,CHEMBL4761704,0.96,Yes,6.017728767
CHEMBL4706796,Inhibition of human ERG by patch clamp electrophysiology assay,Cc1cc(NC2CCc3cc(F)ccc3C2)n2nc(C(C)(F)F)nc2n1,J Med Chem,CHEMBL4740960,0.7,Yes,6.15490196
CHEMBL4706796,Inhibition of human ERG by patch clamp electrophysiology assay,Cc1cc(NC2CCc3cc(Br)ccc3C2)n2nc(C(C)(F)F)nc2n1,J Med Chem,CHEMBL4747214,0.5,Yes,6.301029996
CHEMBL4706939,Displacement of [3H]astemizole from human ERG expressed in HEK293 cells by radioligand binding assay,Cc1cnc(-c2cnc(Nc3cnc(C#N)cn3)cc2NC[C@H]2CNCCO2)s1,J Med Chem,CHEMBL4742233,56,No,4.251811973
CHEMBL4707280,Inhibition of human ERG by fluorescence polarization assay,COc1ccc(-c2nc(N3CCOCC3)c3sc(CN(C)c4ncc(C(=O)NO)cn4)cc3n2)cn1,J Med Chem,CHEMBL3622533,79.5,No,4.099632871
CHEMBL4709471,Inhibition of human ERG,Cc1cccn(-c2ccc(-c3ccc4c(C(=O)NCC5CC5)n[nH]c4c3)c(Cl)c2)c1=O,Eur J Med Chem,CHEMBL4781551,82.3,No,4.084600165
CHEMBL4709471,Inhibition of human ERG,CN[C@@H]1C[C@H]2O[C@@](C)([C@@H]1OC)n1c3ccccc3c3c4c(c5c6ccccc6n2c5c31)C(=O)NC4,Eur J Med Chem,CHEMBL388978,90.4,No,4.04383157
CHEMBL4709471,Inhibition of human ERG,Cc1nc(Nc2n[nH]c3c2CN(C(=O)N[C@H](CN(C)C)c2ccccc2)C3(C)C)c2sccc2n1,Eur J Med Chem,CHEMBL3128043,42.1,No,4.375717904
CHEMBL4709471,Inhibition of human ERG,Cc1cccn(-c2ccc(-c3ccc4c(C(=O)NCc5ccncc5)n[nH]c4c3)c(Cl)c2)c1=O,Eur J Med Chem,CHEMBL4758500,41.1,No,4.386158178
CHEMBL4709848,Inhibition of human ERG expressed in HEK293 cells by whole-cell patch clamp method,Cc1nc2n(c(=O)c1CCN1CCC(c3noc4cc(F)ccc34)CC1)CCCC2,Eur J Med Chem,CHEMBL85,0.167,Yes,6.777283529
CHEMBL4709848,Inhibition of human ERG expressed in HEK293 cells by whole-cell patch clamp method,O=C1CCc2ccc(OCCCCN3CCN(c4cccc(Cl)c4Cl)CC3)cc2N1,Eur J Med Chem,CHEMBL1112,0.896,Yes,6.04769199
CHEMBL4709848,Inhibition of human ERG expressed in HEK293 cells by whole-cell patch clamp method,Cn1ccc2ccc(OCCCN3CCC(c4noc5cc(F)ccc45)CC3)cc2c1=O,Eur J Med Chem,CHEMBL4743324,0.598,Yes,6.223298816
CHEMBL4712777,Inhibition of fluorescence tracer red binding to human ERG measured after 4 hrs by fluorescence polarization assay,O=S(=O)(/C=C/c1ncccc1Cl)c1ccccc1Cl,Eur J Med Chem,CHEMBL4793600,110,No,3.958607315
CHEMBL4712777,Inhibition of fluorescence tracer red binding to human ERG measured after 4 hrs by fluorescence polarization assay,Cl.O=S(=O)(/C=C/c1ncccc1F)c1ccc(OCCCN2CCOCC2)cc1,Eur J Med Chem,CHEMBL4465428,112,No,3.950781977
CHEMBL4717446,Inhibition of human ERG expressed in HEK293 cells assessed as reduction in S35-MK-0499 binding,Cc1cc(-c2ccc3c(c2)-c2nnc(Oc4cccc(OC(F)(F)F)c4)n2CCO3)ccn1,Bioorg Med Chem Lett,CHEMBL4751613,0.693,Yes,6.159266765
CHEMBL4717446,Inhibition of human ERG expressed in HEK293 cells assessed as reduction in S35-MK-0499 binding,Cc1cc(-c2ccc3c(c2)-c2nnc(Oc4cccc(Cl)c4)n2CCO3)ccn1,Bioorg Med Chem Lett,CHEMBL4761139,0.931,Yes,6.031050319
CHEMBL4717446,Inhibition of human ERG expressed in HEK293 cells assessed as reduction in S35-MK-0499 binding,Cc1cc(-c2ccc3c(c2)-c2nnc(Nc4cccc(OC(F)(F)F)c4)n2CCO3)ccn1,Bioorg Med Chem Lett,CHEMBL4798957,0.236,Yes,6.627087997
CHEMBL4717446,Inhibition of human ERG expressed in HEK293 cells assessed as reduction in S35-MK-0499 binding,FC(F)(F)Oc1cccc(Nc2nnc3n2CCOc2ccc(-c4ccncc4)cc2-3)c1,Bioorg Med Chem Lett,CHEMBL4755454,0.605,Yes,6.218244625
CHEMBL4717446,Inhibition of human ERG expressed in HEK293 cells assessed as reduction in S35-MK-0499 binding,CCc1cc(-c2ccc3c(c2)-c2nnc(Nc4cccc(C(F)(F)F)c4)n2CCO3)ccn1,Bioorg Med Chem Lett,CHEMBL4752684,0.334,Yes,6.476253533
CHEMBL4717446,Inhibition of human ERG expressed in HEK293 cells assessed as reduction in S35-MK-0499 binding,Cc1cc(-c2ccc3c(c2)-c2nnc(Nc4cccc(C(F)(F)F)c4)n2CCO3)ccn1,Bioorg Med Chem Lett,CHEMBL4788072,0.388,Yes,6.411168274
CHEMBL4717446,Inhibition of human ERG expressed in HEK293 cells assessed as reduction in S35-MK-0499 binding,FC(F)(F)c1cccc(Nc2nnc3n2CCOc2ccc(-c4ccncc4)cc2-3)c1,Bioorg Med Chem Lett,CHEMBL4790150,0.557,Yes,6.254144805
CHEMBL4717446,Inhibition of human ERG expressed in HEK293 cells assessed as reduction in S35-MK-0499 binding,Cc1cc(-c2ccc3c(c2)-c2nnc(Nc4cccc(Cl)c4)n2CCO3)ccn1,Bioorg Med Chem Lett,CHEMBL4750179,0.428,Yes,6.368556231
CHEMBL4717446,Inhibition of human ERG expressed in HEK293 cells assessed as reduction in S35-MK-0499 binding,O=C(Nc1ccc(Cl)c(Cl)c1)N1CCOc2ccc(-c3ccncc3)cc2C1,Bioorg Med Chem Lett,CHEMBL4755668,2030,No,2.692503962
CHEMBL4717446,Inhibition of human ERG expressed in HEK293 cells assessed as reduction in S35-MK-0499 binding,O=C(Nc1cccc(Cl)c1)N1CCOc2ccc(-c3ccncc3)cc2C1,Bioorg Med Chem Lett,CHEMBL4787638,8340,No,2.078833949
CHEMBL4721729,Inhibition of human ERG transfected in HEK293 cells assessed as reduction in channel current at -80 mV holding potential by whole-cell patch clamp method,NC[C@H](NC(=O)c1ccc(-c2cc(F)c(Cl)c(F)c2)[nH]1)c1nc(CO)cs1,Eur J Med Chem,CHEMBL4761836,0.9,Yes,6.045757491
CHEMBL4723228,Inhibition of human ERG channel in presence of dofetilide by competition binding assay,COCCOc1cc(NC(=O)N2CCCc3cc(C4CCN(CC(F)(F)F)CC4)c(C=O)nc32)ncc1C#N,J Med Chem,CHEMBL4764678,0.5,Yes,6.301029996
CHEMBL4724824,Inhibition of human ERG,CCOc1cc(C(=O)N2CCC(N3CCCC3)CC2)ccc1Nc1cc2c(cn1)N(C)C(=O)c1ccccc1N2C,Bioorg Med Chem,CHEMBL4757477,0.32,Yes,6.494850022
CHEMBL4725052,Inhibition of human ERG by fluorescence polarization assay,Nc1cc(F)c(S(=O)(=O)N2CCC(O)CC2)cc1C(=O)Nc1ccc(F)c(F)c1,ACS Med Chem Lett,CHEMBL4761323,50,No,4.301029996
CHEMBL4729806,Inhibition of human ERG by patch-clamp method,CC(=O)Nc1ccc(OCCCCN2CCC(c3noc4cc(F)ccc34)CC2)cc1,Bioorg Med Chem Lett,CHEMBL4794963,0.3691,Yes,6.432855955
CHEMBL4731940,Inhibition of human ERG,CSc1ccccc1C(=O)NCCCC[C@H](NC(=O)c1cncs1)c1ncc(-c2ccc3ccccc3c2)[nH]1,ACS Med Chem Lett,CHEMBL4763995,0.016,Yes,7.795880017
CHEMBL4734907,Displacement of [3H]dofetilide from human ERG stably expressed in HEK293 cell membranes assessed as unlabelled dofetilide IC50 at 10 uM measured after 60 mins by microbeta liquid scintillation counting method (Rvb = 9.1 to 11.7 nM),O=C(COc1ccc(C(=O)c2ccccc2Br)cc1)Nc1cccnc1,Eur J Med Chem,CHEMBL3740963,0.0356,Yes,7.448550002
CHEMBL4734907,Displacement of [3H]dofetilide from human ERG stably expressed in HEK293 cell membranes assessed as unlabelled dofetilide IC50 at 10 uM measured after 60 mins by microbeta liquid scintillation counting method (Rvb = 9.1 to 11.7 nM),O=C(COc1ccc(C(=O)c2cc(Cl)ccc2Br)cc1)Nc1ccncc1,Eur J Med Chem,CHEMBL4791562,0.0437,Yes,7.359518563
CHEMBL4734907,Displacement of [3H]dofetilide from human ERG stably expressed in HEK293 cell membranes assessed as unlabelled dofetilide IC50 at 10 uM measured after 60 mins by microbeta liquid scintillation counting method (Rvb = 9.1 to 11.7 nM),O=C(COc1ccc(C(=O)c2cc(Cl)ccc2Br)cc1)Nc1ccnc(F)c1,Eur J Med Chem,CHEMBL4779384,0.0176,Yes,7.754487332
CHEMBL4734907,Displacement of [3H]dofetilide from human ERG stably expressed in HEK293 cell membranes assessed as unlabelled dofetilide IC50 at 10 uM measured after 60 mins by microbeta liquid scintillation counting method (Rvb = 9.1 to 11.7 nM),N#Cc1cc(NC(=O)COc2ccc(C(=O)c3cc(Cl)ccc3Br)cc2)ccc1F,Eur J Med Chem,CHEMBL4777849,0.0695,Yes,7.158015195
CHEMBL4734907,Displacement of [3H]dofetilide from human ERG stably expressed in HEK293 cell membranes assessed as unlabelled dofetilide IC50 at 10 uM measured after 60 mins by microbeta liquid scintillation counting method (Rvb = 9.1 to 11.7 nM),CNC(=O)c1cccc(NC(=O)COc2ccc(C(=O)c3cc(Cl)ccc3Br)cc2)c1,Eur J Med Chem,CHEMBL4755955,0.022,Yes,7.657577319
CHEMBL4734907,Displacement of [3H]dofetilide from human ERG stably expressed in HEK293 cell membranes assessed as unlabelled dofetilide IC50 at 10 uM measured after 60 mins by microbeta liquid scintillation counting method (Rvb = 9.1 to 11.7 nM),O=C(COc1ccc(C(=O)c2cc(Cl)ccc2Br)cc1)Nc1cccc(C(=O)NCC2CC2)c1,Eur J Med Chem,CHEMBL4800393,0.026,Yes,7.585026652
CHEMBL4734908,Displacement of [3H]dofetilide from human ERG stably expressed in HEK293 cell membranes assessed as unlabelled dofetilide IC50 at 3 uM measured after 60 mins by microbeta liquid scintillation counting method (Rvb = 9.1 to 11.7 nM),O=C(COc1ccc(C(=O)c2cc(Cl)ccc2Br)cc1)Nc1cccnc1,Eur J Med Chem,CHEMBL4750212,0.0347,Yes,7.459670525
CHEMBL4734908,Displacement of [3H]dofetilide from human ERG stably expressed in HEK293 cell membranes assessed as unlabelled dofetilide IC50 at 3 uM measured after 60 mins by microbeta liquid scintillation counting method (Rvb = 9.1 to 11.7 nM),Cc1cc(NC(=O)COc2ccc(C(=O)c3cc(Cl)ccc3Br)cc2)ccn1,Eur J Med Chem,CHEMBL4781970,0.0597,Yes,7.224025669
CHEMBL4734908,Displacement of [3H]dofetilide from human ERG stably expressed in HEK293 cell membranes assessed as unlabelled dofetilide IC50 at 3 uM measured after 60 mins by microbeta liquid scintillation counting method (Rvb = 9.1 to 11.7 nM),Cc1cnccc1NC(=O)COc1ccc(C(=O)c2cc(Cl)ccc2Br)cc1,Eur J Med Chem,CHEMBL4790592,0.0141,Yes,7.850780887
CHEMBL4734908,Displacement of [3H]dofetilide from human ERG stably expressed in HEK293 cell membranes assessed as unlabelled dofetilide IC50 at 3 uM measured after 60 mins by microbeta liquid scintillation counting method (Rvb = 9.1 to 11.7 nM),Cc1ccc(C#N)cc1NC(=O)COc1ccc(C(=O)c2cc(Cl)ccc2Br)cc1,Eur J Med Chem,CHEMBL4799702,0.0128,Yes,7.89279003
CHEMBL4734908,Displacement of [3H]dofetilide from human ERG stably expressed in HEK293 cell membranes assessed as unlabelled dofetilide IC50 at 3 uM measured after 60 mins by microbeta liquid scintillation counting method (Rvb = 9.1 to 11.7 nM),N#Cc1cccc(NC(=O)COc2ccc(C(=O)c3cc(Cl)ccc3Br)cc2)c1F,Eur J Med Chem,CHEMBL4791914,0.0127,Yes,7.896196279
CHEMBL4734908,Displacement of [3H]dofetilide from human ERG stably expressed in HEK293 cell membranes assessed as unlabelled dofetilide IC50 at 3 uM measured after 60 mins by microbeta liquid scintillation counting method (Rvb = 9.1 to 11.7 nM),N#Cc1cncc(NC(=O)COc2ccc(C(=O)c3cc(Cl)ccc3Br)cc2)c1,Eur J Med Chem,CHEMBL4782998,0.0189,Yes,7.723538196
CHEMBL4734908,Displacement of [3H]dofetilide from human ERG stably expressed in HEK293 cell membranes assessed as unlabelled dofetilide IC50 at 3 uM measured after 60 mins by microbeta liquid scintillation counting method (Rvb = 9.1 to 11.7 nM),O=C(COc1ccc(C(=O)c2cc(Cl)ccc2Br)cc1)Nc1cccc(C(=O)NC2CC2)c1,Eur J Med Chem,CHEMBL4785272,0.0112,Yes,7.950781977
CHEMBL4734908,Displacement of [3H]dofetilide from human ERG stably expressed in HEK293 cell membranes assessed as unlabelled dofetilide IC50 at 3 uM measured after 60 mins by microbeta liquid scintillation counting method (Rvb = 9.1 to 11.7 nM),O=C(COc1ccc(C(=O)c2cc(Cl)ccc2Br)cc1)Nc1ccc(Cl)c(C(=O)NCC2CC2)c1,Eur J Med Chem,CHEMBL4748494,0.0178,Yes,7.749579998
CHEMBL4734909,Displacement of [3H]dofetilide from human ERG stably expressed in HEK293 cell membranes assessed as unlabelled dofetilide IC50 at 1 uM measured after 60 mins by microbeta liquid scintillation counting method (Rvb = 9.1 to 11.7 nM),N#Cc1cccc(NC(=O)COc2ccc(C(=O)c3cc(Cl)ccc3Br)cc2)c1,Eur J Med Chem,CHEMBL4797829,0.0283,Yes,7.548213564
CHEMBL4734909,Displacement of [3H]dofetilide from human ERG stably expressed in HEK293 cell membranes assessed as unlabelled dofetilide IC50 at 1 uM measured after 60 mins by microbeta liquid scintillation counting method (Rvb = 9.1 to 11.7 nM),O=C(COc1ccc(C(=O)c2cc(Cl)ccc2Br)cc1)Nc1cncc(C(=O)NCC2CC2)c1,Eur J Med Chem,CHEMBL4791538,0.0195,Yes,7.709965389
CHEMBL4734910,Displacement of [3H]dofetilide from human ERG stably expressed in HEK293 cell membranes assessed as unlabelled dofetilide IC50 at 0.5 uM measured after 60 mins by microbeta liquid scintillation counting method (Rvb = 9.1 to 11.7 nM),O=C(COc1ccc(C(=O)c2cc(Cl)ccc2Br)cc1)Nc1ccnc(C(=O)NCC2CC2)c1,Eur J Med Chem,CHEMBL4781787,0.0175,Yes,7.756961951
CHEMBL4742499,Inhibition of human ERG,CC(=O)N1CCc2nc(N3CCC(Oc4ccc(F)cc4F)CC3)c(N[C@H]3CCOC3)nc2C1,,CHEMBL3962956,0.505,Yes,6.296708622
CHEMBL4766130,Inhibition of human ERG expressed in CHO cells at -80 mV holding potential by automated Qpatch electrophysiological assay,Cc1ccc(NC(=O)c2cccc(C(F)(F)F)c2)cc1C#Cc1nn(C2CCN(C)CC2)c2ncnc(N)c12,J Med Chem,CHEMBL4787515,0.6,Yes,6.22184875
CHEMBL4766130,Inhibition of human ERG expressed in CHO cells at -80 mV holding potential by automated Qpatch electrophysiological assay,Cc1ccc(NC(=O)c2cccc(C(F)(F)F)c2)cc1C#Cc1nn([C@@H]2CCN(C)C2)c2ncnc(N)c12,J Med Chem,CHEMBL4783566,0.68,Yes,6.167491087
CHEMBL4766428,Inhibition of human ERG,COc1ccc(C(NC(=O)c2cnc(-n3cccn3)nc2O)c2ccc(OC)cc2)cc1,J Med Chem,CHEMBL4785918,0.9,Yes,6.045757491
CHEMBL4769893,Inhibition of human ERG,COc1ccc2ncc(F)c(CC[C@@]3(O)CO[C@@H]4[C@@H](NCc5cc6c(cn5)OCCO6)CO[C@@H]43)c2n1,Eur J Med Chem,CHEMBL4788651,66,No,4.180456064
CHEMBL4770548,Inhibition of human ERG expressed in CHO cells by patch clamp method,COc1ccc(-c2ccccc2N2CCN(CCCCOc3ccc4c(c3)NC(=O)C(C)O4)CC2)cc1,Eur J Med Chem,CHEMBL4799274,0.448,Yes,6.348721986
CHEMBL4774139,Inhibition of human ERG,O=C(CCCCCCC(=O)Nc1ccccc1)NO,Eur J Med Chem,CHEMBL98,0.322,Yes,6.492144128
CHEMBL4774539,Inhibition of human ERG stably expressed in HEK293 cells by whole-cell manual patch clamp method,CN(CCOc1ccc(NS(C)(=O)=O)cc1)CCc1ccc(NS(C)(=O)=O)cc1,Eur J Med Chem,CHEMBL473,0.013,Yes,7.886056648
CHEMBL4774973,Inhibition of human ERG incubated for 4 hrs by competitive fluorescence tracer binding based assay,Cc1cccc(CCN2CCC(C(=O)c3ccc(NS(C)(=O)=O)cc3)CC2)n1.Cl.Cl,Eur J Med Chem,CHEMBL536480,0.011,Yes,7.958607315
CHEMBL4775409,Inhibition of human ERG by patch clamp assay,C[C@H](Oc1cc2cc(F)cc(F)c2nc1N)c1cc(C(=O)O)ccc1-n1cccn1,J Med Chem,CHEMBL4785484,144,No,3.841637508
CHEMBL4775409,Inhibition of human ERG by patch clamp assay,C[C@H](Oc1cc2cc(F)ccc2nc1N)c1[nH]c(=O)ccc1-n1cccn1,J Med Chem,CHEMBL4650304,43,No,4.366531544
CHEMBL4809364,Inhibition of human ERG expressed in CHO-K1 cells by Qpatch clamp method,Cc1c(N2CC[C@@H]([C@H](C)N)C2)c(F)cc2cc(C(=O)O)c(=O)n(C3CC3)c12,J Med Chem,CHEMBL4643875,214,No,3.669586227
CHEMBL4809364,Inhibition of human ERG expressed in CHO-K1 cells by Qpatch clamp method,Cc1c(N2CCC(C3(N)CC3)C2)c(F)cc2cc(C(=O)O)c(=O)n(C3CC3)c12,J Med Chem,CHEMBL4846404,109,No,3.962573502
CHEMBL4809364,Inhibition of human ERG expressed in CHO-K1 cells by Qpatch clamp method,Cc1c(N2CC[C@@H](C3(N)CC3)C2)c(F)cc2cc(C(=O)O)c(=O)n(C3CC3)c12,J Med Chem,CHEMBL4857241,136,No,3.866461092
CHEMBL4809364,Inhibition of human ERG expressed in CHO-K1 cells by Qpatch clamp method,Cc1c(N2CCC(C3(N)CC3)C2)c(F)cc2c(Cc3n[nH]c(=O)o3)cc(=O)n(C3CC3)c12,J Med Chem,CHEMBL4869164,188,No,3.725842151
CHEMBL4809364,Inhibition of human ERG expressed in CHO-K1 cells by Qpatch clamp method,Cc1c(N2CCC(C3(N)CC3)C2)c(F)cc2c(CC(=O)N(C)C)cc(=O)n(C3CC3)c12,J Med Chem,CHEMBL4865462,293,No,3.53313238
CHEMBL4809364,Inhibition of human ERG expressed in CHO-K1 cells by Qpatch clamp method,C[C@H]1CCc2c(N3CC[C@@H](C4(N)CC4)C3)c(F)cc3cc(C(=O)O)c(=O)n1c23,J Med Chem,CHEMBL4855895,297,No,3.527243551
CHEMBL4809364,Inhibition of human ERG expressed in CHO-K1 cells by Qpatch clamp method,C[C@H]1COc2c(N3CC[C@@H](C4(N)CC4)C3)c(F)c(F)c3cc(C(=O)O)c(=O)n1c23,J Med Chem,CHEMBL4849541,211,No,3.675717545
CHEMBL4809364,Inhibition of human ERG expressed in CHO-K1 cells by Qpatch clamp method,C[C@H]1COc2c(N3CC[C@@H](C4(N)CC4)C3)c(F)c(Cl)c3cc(C(=O)O)c(=O)n1c23,J Med Chem,CHEMBL4855694,150,No,3.823908741
CHEMBL4809364,Inhibition of human ERG expressed in CHO-K1 cells by Qpatch clamp method,C[C@H]1COc2c(N3CC[C@@H](C4(N)CC4)C3)ccc3cc(C(=O)O)c(=O)n1c23,J Med Chem,CHEMBL4847738,90,No,4.045757491
CHEMBL4809364,Inhibition of human ERG expressed in CHO-K1 cells by Qpatch clamp method,C[C@H]1COc2c(N3CC[C@@H](C4(N)CC4)C3)cc(F)c3cc(C(=O)O)c(=O)n1c23,J Med Chem,CHEMBL4851838,126,No,3.899629455
CHEMBL4809364,Inhibition of human ERG expressed in CHO-K1 cells by Qpatch clamp method,C[C@H]1COc2c(N3CC[C@@H](C4(N)CC4)C3)cc(Cl)c3cc(C(=O)O)c(=O)n1c23,J Med Chem,CHEMBL4867992,42,No,4.37675071
CHEMBL4809365,Inhibition of human ERG expressed in CHO-K1 cells by manual patch clamp method,Cc1c(N2CC[C@@H]([C@H](C)N)C2)c(F)cc2ccc(=O)n(C3CC3)c12,J Med Chem,CHEMBL4640061,49,No,4.30980392
CHEMBL4809366,Inhibition of human ERG expressed in CHO-K1 cells by long incubation protocol based Qpatch clamp method,Cc1c(N2CC3CC3(N)C2)c(F)cc2c(CN)cc(=O)n(C3CC3)c12,J Med Chem,CHEMBL4633030,114,No,3.943095149
CHEMBL4809366,Inhibition of human ERG expressed in CHO-K1 cells by long incubation protocol based Qpatch clamp method,C[C@H]1COc2c(N3C[C@H]4CCC[C@@H](N)[C@H]4C3)c(F)cc3cc(C(=O)O)c(=O)n1c23,J Med Chem,CHEMBL4874636,127,No,3.896196279
CHEMBL4809367,Inhibition of human ERG expressed in CHO cells by whole cell patch-clamp method,COc1c(N2C[C@@H]3CCCN[C@@H]3C2)c(F)cc2c(=O)c(C(=O)O)cn(C3CC3)c12,J Med Chem,CHEMBL32,129,No,3.88941029
CHEMBL4811872,Inhibition of human ERG expressed in HEK293 cells maintained at -80 mV membrane potential by manual patch-clamp technique,C[C@@]1(c2cc(NC(=O)c3ccc(C#N)cn3)ccc2F)C=CSC(N)=N1,J Med Chem,CHEMBL3916243,0.5,Yes,6.301029996
CHEMBL4821061,Inhibition of human ERG by automated patch method relative to control,Cc1nc2n(c(=O)c1CCN1CCC(c3noc4cc(F)ccc34)CC1)CCCC2,Bioorg Med Chem Lett,CHEMBL85,0.167,Yes,6.777283529
CHEMBL4821061,Inhibition of human ERG by automated patch method relative to control,O=C1CCc2ccc(OCCCCN3CCN(c4cccc(Cl)c4Cl)CC3)cc2N1,Bioorg Med Chem Lett,CHEMBL1112,0.8965,Yes,6.047449706
CHEMBL4825323,Inhibition of human ERG by patch clamp assay,COc1c(N)ncnc1N1CCC(c2nc(-c3ccc(F)c(C(F)(F)F)c3)cn2C)CC1,Bioorg Med Chem Lett,CHEMBL3964789,670,No,3.173925197
CHEMBL4825323,Inhibition of human ERG by patch clamp assay,CN(C)CCn1cc(-c2ccc(F)c(C(F)(F)F)c2)nc1C1CCN(c2ncnc(N)c2C2CC2)CC1,Bioorg Med Chem Lett,CHEMBL3900512,0.83,Yes,6.080921908
CHEMBL4825323,Inhibition of human ERG by patch clamp assay,C=Cc1c(N)ncnc1N1CCC(c2nc(-c3ccc(F)c(C(F)(F)F)c3)cn2CCN2CCC2)CC1,Bioorg Med Chem Lett,CHEMBL3931504,0.93,Yes,6.031517051
CHEMBL4825323,Inhibition of human ERG by patch clamp assay,N#Cc1c(N)ncnc1N1CCC(c2nc(-c3ccc(F)c(C(F)(F)F)c3)cn2CCN2CCC2)CC1,Bioorg Med Chem Lett,CHEMBL3962807,0.7,Yes,6.15490196
CHEMBL4825561,Inhibition of ERG in human VCaP cells after 48 hrs by Western blotting analysis,CN(C)c1ccc(/N=N/c2ccccn2)c(O)c1,ACS Med Chem Lett,CHEMBL4857685,0.23,Yes,6.638272164
CHEMBL4825561,Inhibition of ERG in human VCaP cells after 48 hrs by Western blotting analysis,Oc1ccc2ccccc2c1/N=N/c1nccs1,ACS Med Chem Lett,CHEMBL2094383,0.31,Yes,6.508638306
CHEMBL4825561,Inhibition of ERG in human VCaP cells after 48 hrs by Western blotting analysis,CN(C)c1ccc(/N=N/c2ccccn2)c(O)c1.CS(=O)(=O)O,ACS Med Chem Lett,CHEMBL4858983,0.13,Yes,6.886056648
CHEMBL4825561,Inhibition of ERG in human VCaP cells after 48 hrs by Western blotting analysis,CN(C)c1ccc(/N=N/c2ccccn2)c(O)c1.Cl,ACS Med Chem Lett,CHEMBL4849321,0.22,Yes,6.657577319
CHEMBL4825561,Inhibition of ERG in human VCaP cells after 48 hrs by Western blotting analysis,CN(C)c1ccc(/N=N/c2ccccn2)c(O)c1.O=S(=O)(O)c1ccccc1,ACS Med Chem Lett,CHEMBL4879307,0.21,Yes,6.677780705
CHEMBL4825561,Inhibition of ERG in human VCaP cells after 48 hrs by Western blotting analysis,CN(C)c1ccc(/N=N/c2ccccn2)c(O)c1.O=C(O)c1cc(O)ccc1O,ACS Med Chem Lett,CHEMBL4857416,0.24,Yes,6.619788758
CHEMBL4825561,Inhibition of ERG in human VCaP cells after 48 hrs by Western blotting analysis,CN(C)c1ccc(/N=N/c2ccccn2)c(O)c1.O=C(O)/C=C\C(=O)O,ACS Med Chem Lett,CHEMBL4849849,0.26,Yes,6.585026652
CHEMBL4825561,Inhibition of ERG in human VCaP cells after 48 hrs by Western blotting analysis,Br.CN(C)c1ccc(/N=N/c2ccccn2)c(O)c1,ACS Med Chem Lett,CHEMBL4866923,0.24,Yes,6.619788758
CHEMBL4825561,Inhibition of ERG in human VCaP cells after 48 hrs by Western blotting analysis,CN(C)c1ccc(/N=N/c2ccccn2)c(O)c1.O=S(=O)(O)O,ACS Med Chem Lett,CHEMBL4858940,0.26,Yes,6.585026652
CHEMBL4825561,Inhibition of ERG in human VCaP cells after 48 hrs by Western blotting analysis,CN(C)c1ccc(/N=N/c2ccccn2)c([O-])c1.[Na+],ACS Med Chem Lett,CHEMBL4846230,0.11,Yes,6.958607315
CHEMBL4825561,Inhibition of ERG in human VCaP cells after 48 hrs by Western blotting analysis,CN(C)c1ccc(/N=N/c2ccccn2)c(O)c1.O=[N+]([O-])O,ACS Med Chem Lett,CHEMBL4859906,0.16,Yes,6.795880017
CHEMBL4825561,Inhibition of ERG in human VCaP cells after 48 hrs by Western blotting analysis,CN(C)c1ccc(/N=N/c2ccccn2)c(O)c1.O=C(O)CCC(=O)O,ACS Med Chem Lett,CHEMBL4849545,0.22,Yes,6.657577319
CHEMBL4825561,Inhibition of ERG in human VCaP cells after 48 hrs by Western blotting analysis,CN(C)c1ccc(/N=N/c2ccccn2)c(O)c1.O=S(=O)(O)CCS(=O)(=O)O,ACS Med Chem Lett,CHEMBL4871821,0.16,Yes,6.795880017
CHEMBL4825561,Inhibition of ERG in human VCaP cells after 48 hrs by Western blotting analysis,CN(C)c1ccc(/N=N/c2ccccn2)c(O)c1.O=C(O)C(=O)O,ACS Med Chem Lett,CHEMBL4853476,0.15,Yes,6.823908741
CHEMBL4825561,Inhibition of ERG in human VCaP cells after 48 hrs by Western blotting analysis,CN(C)c1ccc(/N=N/c2ccccn2)c(O)c1.Cc1ccc(S(=O)(=O)O)cc1,ACS Med Chem Lett,CHEMBL4869333,0.24,Yes,6.619788758
CHEMBL4832310,Inhibition of human ERG incubated for 3 hrs by competitive fluorescence tracer binding based assay,Cc1cccc(CCN2CCC(C(=O)c3ccc(NS(C)(=O)=O)cc3)CC2)n1,Eur J Med Chem,CHEMBL327980,0.0242,Yes,7.616184634
CHEMBL4832854,Inhibition of human ERG expressed in CHO cells by manual patch clamp technique,Cc1cc(/C=C/C#N)cc(C)c1Nc1ccnc(Nc2ccc(C#N)cc2)n1,J Med Chem,CHEMBL175691,0.5,Yes,6.301029996
CHEMBL4832854,Inhibition of human ERG expressed in CHO cells by manual patch clamp technique,Cc1cc(C#N)cc(C)c1Oc1nc(NC2CCN(Cc3ccc(S(N)(=O)=O)cc3)CC2)nc2ccsc12,J Med Chem,CHEMBL3929927,0.13,Yes,6.886056648
CHEMBL4832854,Inhibition of human ERG expressed in CHO cells by manual patch clamp technique,Cc1cc(/C=C/C#N)cc(C)c1Oc1nc(NC2CCN(Cc3ccc(S(N)(=O)=O)cc3)CC2)nc2ccsc12,J Med Chem,CHEMBL4094163,0.18,Yes,6.744727495
CHEMBL4833086,Inhibition of human ERG,CCS(=O)(=O)c1ccc(C(NC(=O)CC2CC2)C(=O)Nc2ccc(C(O)(C(F)(F)F)C(F)(F)F)cc2)nc1,J Med Chem,CHEMBL4849302,34,No,4.468521083
CHEMBL4833086,Inhibition of human ERG,CCS(=O)(=O)c1ccc2c(c1)CN(C(C)=O)C2C(=O)Nc1ccc(C(O)(C(F)(F)F)C(F)(F)F)cc1,J Med Chem,CHEMBL4865352,34,No,4.468521083
CHEMBL4833086,Inhibition of human ERG,CCS(=O)(=O)c1ccc2c(c1)CN(C(C)=O)[C@H]2C(=O)Nc1ccc(C(O)(C(F)(F)F)C(F)(F)F)cc1,J Med Chem,CHEMBL4854122,40,No,4.397940009
CHEMBL4835111,Inhibition of human ERG,CCNC(=O)c1cc(Cc2cccc3[nH]ccc23)nc(-c2cn(C)nn2)c1,J Med Chem,CHEMBL4856853,31.62278,No,4.499999953
CHEMBL4835111,Inhibition of human ERG,C[C@H](Oc1ccc(C(=O)NC2CC2)cc1-c1cn(C)nn1)c1ccccn1,J Med Chem,CHEMBL4867703,39.81072,No,4.399999968
CHEMBL4839289,Inhibition of human ERG stably expressed in CHO-K1 cells at -90 mV holding potential by automated Q-patch clamp method,COc1ccc(CCN2CCC(Nc3nc4ccccc4n3Cc3ccc(F)cc3)CC2)cc1,ACS Med Chem Lett,CHEMBL296419,0.0042,Yes,8.37675071
CHEMBL4839289,Inhibition of human ERG stably expressed in CHO-K1 cells at -90 mV holding potential by automated Q-patch clamp method,COc1ccc(CCNCCCNc2nc3ccccc3n2Cc2ccc(F)cc2)cc1,ACS Med Chem Lett,CHEMBL4868855,0.41,Yes,6.387216143
CHEMBL4839289,Inhibition of human ERG stably expressed in CHO-K1 cells at -90 mV holding potential by automated Q-patch clamp method,N#Cc1ccc(CCN2CCC(Nc3nc4ccccc4[nH]3)CC2)cc1,ACS Med Chem Lett,CHEMBL4868736,0.09,Yes,7.045757491
CHEMBL4839289,Inhibition of human ERG stably expressed in CHO-K1 cells at -90 mV holding potential by automated Q-patch clamp method,N#Cc1ccc(CCN2CCC(Nc3nc4ccccc4n3Cc3ccc(C#N)cc3)CC2)cc1,ACS Med Chem Lett,CHEMBL4870175,0.05,Yes,7.301029996
CHEMBL4839289,Inhibition of human ERG stably expressed in CHO-K1 cells at -90 mV holding potential by automated Q-patch clamp method,CS(=O)(=O)c1ccc(Cn2c(NC3CCN(CCc4ccc(C#N)cc4)CC3)nc3ccccc32)cc1,ACS Med Chem Lett,CHEMBL4847937,0.11,Yes,6.958607315
CHEMBL4839289,Inhibition of human ERG stably expressed in CHO-K1 cells at -90 mV holding potential by automated Q-patch clamp method,N#Cc1ccc(CCN2CCC(Nc3nc4ccccc4n3Cc3ccc(C(F)(F)F)nc3)CC2)cc1,ACS Med Chem Lett,CHEMBL4870498,0.97,Yes,6.013228266
CHEMBL4839289,Inhibition of human ERG stably expressed in CHO-K1 cells at -90 mV holding potential by automated Q-patch clamp method,N#Cc1ccc(CCN2CCC(Nc3nc4ccccc4n3Cc3ccc(C#N)c(F)c3)CC2)cc1,ACS Med Chem Lett,CHEMBL4867115,0.05,Yes,7.301029996
CHEMBL4839289,Inhibition of human ERG stably expressed in CHO-K1 cells at -90 mV holding potential by automated Q-patch clamp method,COc1ccc(CCN(C)CCCC(C#N)(c2ccc(OC)c(OC)c2)C(C)C)cc1OC,ACS Med Chem Lett,CHEMBL6966,0.2,Yes,6.698970004
CHEMBL4839360,Inhibition of human ERG by patch clamp assay,Fc1cc(F)c(F)c(-c2ccc(N[C@H]3C[C@@H]4CN(CC5CCOCC5)C[C@@H]4C3)nn2)c1,ACS Med Chem Lett,CHEMBL4850236,0.431,Yes,6.36552273
CHEMBL4841563,Inhibition of human ERG expressed in CHO-K1 cells with holding potential -80 mV incubated for 5 mins by patch-clamp assay,Cc1cc(C)cc(NC(=O)c2cncc(-c3cc(C)cc(C)c3)c2N2CCC(N)CC2)c1,Bioorg Med Chem,CHEMBL4863880,0.8,Yes,6.096910013
CHEMBL4841563,Inhibition of human ERG expressed in CHO-K1 cells with holding potential -80 mV incubated for 5 mins by patch-clamp assay,NC1CCN(c2c(NC(=O)c3ccccc3)cncc2-c2cc(Cl)cc(Cl)c2)CC1,Bioorg Med Chem,CHEMBL4854239,0.9,Yes,6.045757491
CHEMBL4841563,Inhibition of human ERG expressed in CHO-K1 cells with holding potential -80 mV incubated for 5 mins by patch-clamp assay,Cc1cc(C)cc(-c2cncc(-c3nc4cc(C(F)(F)F)ccc4[nH]3)c2N2CCC(N)CC2)c1,Bioorg Med Chem,CHEMBL4849848,0.6,Yes,6.22184875
CHEMBL4843253,Inhibition of human ERG by manual patch clamp method,CC[C@@H](NC(=O)c1ccc(Cl)cc1)[C@H]1[C@@H]2C[C@@H](n3cnc4cc(F)c(F)cc43)C[C@@H]21,J Med Chem,CHEMBL4861332,0.79,Yes,6.102372909
CHEMBL4843281,Displacement of Tracer Red from human ERG measured after 4 hrs by fluorescence polarization assay,CCC(NC(=O)c1ccc(Cl)cc1)[C@H]1[C@@H]2C[C@@H](n3cnc4cc(F)ccc43)C[C@@H]21,J Med Chem,CHEMBL4866113,0.18,Yes,6.744727495
CHEMBL4843281,Displacement of Tracer Red from human ERG measured after 4 hrs by fluorescence polarization assay,CCC(NC(=O)c1ccc(Cl)cc1)[C@H]1[C@@H]2C[C@@H](n3cnc4ccccc43)C[C@@H]21,J Med Chem,CHEMBL4878766,0.78,Yes,6.107905397
CHEMBL4843281,Displacement of Tracer Red from human ERG measured after 4 hrs by fluorescence polarization assay,CCC(NC(=O)c1ccc(Cl)cc1)[C@H]1[C@@H]2C[C@@H](n3cnc4cc(C#N)ccc43)C[C@@H]21,J Med Chem,CHEMBL4870583,0.15,Yes,6.823908741
CHEMBL4843281,Displacement of Tracer Red from human ERG measured after 4 hrs by fluorescence polarization assay,CCC(NC(=O)c1ccc(Cl)cc1)[C@H]1[C@@H]2C[C@@H](n3cnc4cc(F)cc(F)c43)C[C@@H]21,J Med Chem,CHEMBL4852566,0.57,Yes,6.244125144
CHEMBL4843281,Displacement of Tracer Red from human ERG measured after 4 hrs by fluorescence polarization assay,CCC(NC(=O)c1ccc(Cl)cc1)[C@H]1[C@@H]2C[C@@H](n3cnc4cnccc43)C[C@@H]21,J Med Chem,CHEMBL4878988,0.059,Yes,7.229147988
CHEMBL4843281,Displacement of Tracer Red from human ERG measured after 4 hrs by fluorescence polarization assay,CCC(NC(=O)c1ccc(Cl)cc1)[C@H]1[C@@H]2C[C@@H](n3cnc4cc(C#N)cnc43)C[C@@H]21,J Med Chem,CHEMBL4879173,0.69,Yes,6.161150909
CHEMBL4843281,Displacement of Tracer Red from human ERG measured after 4 hrs by fluorescence polarization assay,Fc1cc2ncn([C@H]3C[C@@H]4[C@@H](CNC(c5ccc(Cl)cc5)C(F)(F)F)[C@@H]4C3)c2cc1F,J Med Chem,CHEMBL4873747,0.46,Yes,6.337242168
CHEMBL4843281,Displacement of Tracer Red from human ERG measured after 4 hrs by fluorescence polarization assay,CC[C@@H](NC(=O)c1ccc(C#N)cc1)[C@H]1[C@@H]2C[C@@H](n3cnc4ccc(Cl)cc43)C[C@@H]21,J Med Chem,CHEMBL4870418,0.5,Yes,6.301029996
CHEMBL4843281,Displacement of Tracer Red from human ERG measured after 4 hrs by fluorescence polarization assay,C[C@@H](NC(=O)c1ccc(Cl)cc1)[C@H]1[C@@H]2C[C@@H](n3cnc4cc(F)c(F)cc43)C[C@@H]21,J Med Chem,CHEMBL4849414,0.52,Yes,6.283996656
CHEMBL4843281,Displacement of Tracer Red from human ERG measured after 4 hrs by fluorescence polarization assay,O=C(N[C@H](C1CC1)[C@H]1[C@@H]2C[C@@H](n3cnc4cc(F)c(F)cc43)C[C@@H]21)c1ccc(Cl)cc1,J Med Chem,CHEMBL4846356,0.56,Yes,6.251811973
CHEMBL4843281,Displacement of Tracer Red from human ERG measured after 4 hrs by fluorescence polarization assay,CC[C@@H](NC(=O)C12CC(F)(C1)C2)[C@H]1[C@@H]2C[C@@H](n3cnc4cc(F)c(F)cc43)C[C@@H]21,J Med Chem,CHEMBL4859674,48,No,4.318758763
CHEMBL4843290,Inhibition of human ERG expressed in CHO by QPatch assay,C[C@@H](NC(=O)c1ccc(C#N)cc1)[C@H]1[C@@H]2C[C@@H](n3cnc4cc(F)c(F)cc43)C[C@@H]21,J Med Chem,CHEMBL4846783,0.74,Yes,6.13076828
CHEMBL4843627,Inhibition of [S35]-MK-0499 binding to human ERG expressed in HEK293 cells,COc1ncc(-c2ccc(C(=O)O)cc2C)cc1-c1ccc(C(F)(F)F)cc1CN1C(=O)O[C@H](c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@@H]1C,J Med Chem,CHEMBL4852538,0.44,Yes,6.356547324
CHEMBL4845171,Inhibition of human ERG expressed in HEK293 cells at -80 mV holding potential by patch clamp assay,NC(=O)c1ccn(-c2ccc(NCC3(c4ncccc4F)CCC3)nn2)c1,J Med Chem,CHEMBL4858551,97,No,4.013228266
CHEMBL5032179,Inhibition of human ERG by patch clamp assay,CCCC(N)C(=O)NCCc1ccc(-c2ccc(Cl)c(Cl)c2)cc1.Cl,J Med Chem,CHEMBL5082793,39.502,No,4.403380915
CHEMBL5034211,Inhibition of human ERG,NC1=N[C@@]2(c3cc(NC(=O)c4ccc(F)cn4)ccc3F)CN(c3ncc(F)cn3)C[C@H]2CS1,J Med Chem,CHEMBL3667410,0.18,Yes,6.744727495
CHEMBL5036958,Inhibition of hERG expressed in CHO cells by whole-cell QPatch automated patch-clamp technique,C=CC(=O)N1C(=O)CC(c2ccc(F)cc2)Sc2ccccc21,J Med Chem,CHEMBL5071369,37.5,No,4.425968732
CHEMBL5037163,Inhibition of hERG expressed in HEK293 cells,COc1cc(N)c(Cl)cc1C(=O)N[C@H]1CCN(CCCOc2ccc(F)cc2)C[C@H]1OC,J Med Chem,CHEMBL74656,0.0131,Yes,7.882728704
CHEMBL5038401,Inhibition of human ERG expressed in HEK-293 cells by patch clamp method,CNCCNC(=O)c1cc2c([nH]c3c(C)cccc32)c(-c2ccc(Cl)c(Cl)c2)n1.Cl,ACS Med Chem Lett,CHEMBL5070756,0.51,Yes,6.292429824
CHEMBL5039908,Inhibition of human ERG expressed in HEK-293 cells by voltage clamp electrophysiology assay,Cc1c([C@@H](O)CN2CCC3(CC2)CCN(C2=CC(=O)OC2)C3)ccc2c1COC2=O,J Med Chem,CHEMBL5085209,90,No,4.045757491
CHEMBL5039908,Inhibition of human ERG expressed in HEK-293 cells by voltage clamp electrophysiology assay,Cc1c([C@@H](O)CN2CCC3(CC2)CCN(C2=CC(=O)OC2)C3=O)ccc2c1COC2=O,J Med Chem,CHEMBL3895661,31,No,4.508638306
CHEMBL5039908,Inhibition of human ERG expressed in HEK-293 cells by voltage clamp electrophysiology assay,Cc1c([C@@H](O)CN2CCC3(CC2)CC(=O)N(C2=CC(=O)OC2)C3)ccc2c1COC2=O,J Med Chem,CHEMBL5091929,90,No,4.045757491
CHEMBL5039908,Inhibition of human ERG expressed in HEK-293 cells by voltage clamp electrophysiology assay,Cc1c([C@@H](O)CN2CCC3(CC2)CCN(C2=CC(=O)CC2)C3=O)ccc2c1COC2=O,J Med Chem,CHEMBL5080394,83,No,4.080921908
CHEMBL5039908,Inhibition of human ERG expressed in HEK-293 cells by voltage clamp electrophysiology assay,CC1=C(N2CCC3(CCN(C[C@H](O)c4ccc5c(c4C)COC5=O)CC3)C2=O)COC1=O,J Med Chem,CHEMBL3913475,34,No,4.468521083
CHEMBL5039908,Inhibition of human ERG expressed in HEK-293 cells by voltage clamp electrophysiology assay,Cc1c([C@@H](O)CN2CCC3(CC2)CCN(C2=C(Cl)C(=O)OC2)C3=O)ccc2c1COC2=O,J Med Chem,CHEMBL3962588,33,No,4.48148606
CHEMBL5039908,Inhibition of human ERG expressed in HEK-293 cells by voltage clamp electrophysiology assay,Cc1c([C@@H](O)CN2CCC3(CC2)CCN(c2ccc(C#N)cn2)C3)ccc2c1COC2=O,J Med Chem,CHEMBL3622105,96,No,4.017728767
CHEMBL5041215,Inhibition of human ERG by PatchXpress assay,CSCC[C@@H]1NC(=O)CNC(=O)[C@H](CCC(=O)O)NC(=O)[C@@H]2CSSC[C@H](NC(=O)[C@@H](N)Cc3ccc(O)cc3)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](Cc3c[nH]c4ccccc34)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](Cc3c[nH]c4ccccc34)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@H]3CSSC[C@H](NC(=O)[C@H](C(C)C)NC1=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1c[nH]c4ccccc14)C(=O)N[C@H](C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1c[nH]c4ccccc14)C(N)=O)CSSC[C@H](NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CO)NC(=O)[C@H](CC(=O)O)NC3=O)C(=O)N2,J Med Chem,CHEMBL3318147,0.022,Yes,7.657577319
CHEMBL5041215,Inhibition of human ERG by PatchXpress assay,CC(C)C[C@@H]1NC(=O)CNC(=O)[C@H](CCC(=O)O)NC(=O)[C@@H]2CSSC[C@H](NC(=O)[C@@H](N)Cc3ccc(O)cc3)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](Cc3ccccc3)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)C(=O)N3CCC[C@H]3C(=O)N[C@H]3CSSC[C@H](NC(=O)[C@H](C(C)C)NC1=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1c[nH]c4ccccc14)C(=O)N[C@H](C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1c[nH]c4ccccc14)C(N)=O)CSSC[C@H](NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CO)NC(=O)[C@H](CC(=O)O)NC3=O)C(=O)N2,J Med Chem,CHEMBL5085021,0.78,Yes,6.107905397
CHEMBL5042359,Inhibition of human ERG,O=C1COc2ccc(CNC3CCN(CCn4c(=O)ccc5ccc(Oc6ccccn6)nc54)CC3)nc2N1,ACS Med Chem Lett,CHEMBL5085925,155,No,3.809668302
CHEMBL5044152,Inhibition of human ERG by voltage clamp assay,F[C@@H]1CNCC[C@H]1c1cc2nc(Nc3cnn([C@@H]4CC4(F)F)c3Cl)ncc2cc1Cl,J Med Chem,CHEMBL5076674,0.57,Yes,6.244125144
CHEMBL5044152,Inhibition of human ERG by voltage clamp assay,FC1CN(C2CCOC2)CCC1c1cc2nc(Nc3cnn(C4CC4(F)F)c3Cl)ncc2cc1Cl,J Med Chem,CHEMBL5070497,35,No,4.455931956
CHEMBL5046094,Inhibition of [35S]MK-499 binding to hERG expressed in HEK293 cells,C[C@H]1NC(=O)[C@]2(N)CC(F)(F)[C@@H](C)[C@H](/C=C/c3ccc(-c4ccccc4C#N)cn3)[C@H]12,J Med Chem,CHEMBL5081773,33,No,4.48148606
CHEMBL5046094,Inhibition of [35S]MK-499 binding to hERG expressed in HEK293 cells,CNC(=O)N1C[C@H]2[C@H](C)[C@@H](C)[C@H](/C=C/c3ccc(-c4ccccc4C#N)cn3)[C@@H]3[C@@H](C)OC(=O)[C@@]32C1,J Med Chem,CHEMBL5094869,50,No,4.301029996
CHEMBL5046760,Inhibition of human ERG by patch clamp method,C[C@H](C(=O)O)n1nc(Cn2cc3cc(OCC4CC4)c(Cl)cc3n2)c2ccccc2c1=O,J Med Chem,CHEMBL5079623,35.8,No,4.446116973
CHEMBL5047399,Inhibition of hERG expressed in CHO cells at -80 mV holding potential by automated patch clamp method,COc1cc2c(cc1OC)C(=O)C(CC1CCN(Cc3ccccc3)CC1)C2,Eur J Med Chem,CHEMBL502,0.64,Yes,6.193820026
CHEMBL5047399,Inhibition of hERG expressed in CHO cells at -80 mV holding potential by automated patch clamp method,COc1cc(N)c(Cl)cc1C(=O)N[C@H]1CCN(CCCOc2ccc(F)cc2)C[C@H]1OC,Eur J Med Chem,CHEMBL74656,0.056,Yes,7.251811973
CHEMBL5048865,Inhibition of hERG by patch clamp method,CCOP(=O)(Cc1csc(NC(=O)c2cc(Oc3ccc(S(C)(=O)=O)cc3)cc(O[C@@H](C)COC)c2)n1)OCC,J Med Chem,CHEMBL5091943,50,No,4.301029996
CHEMBL5048865,Inhibition of hERG by patch clamp method,CCOP(=O)(Cn1ccc(NC(=O)c2cc(Oc3ccc(S(C)(=O)=O)cc3)cc(OC(CF)CF)c2)n1)OCC,J Med Chem,CHEMBL5081517,44,No,4.356547324
CHEMBL5048865,Inhibition of hERG by patch clamp method,CCOP(=O)(Cn1ccc(NC(=O)c2cc(Oc3ccc(S(=O)(=O)N4CCC4)cc3)cc(OC(C)C)c2)n1)OCC,J Med Chem,CHEMBL5072442,33,No,4.48148606
CHEMBL5049389,Inhibition of hERG,Cc1nc(C)c([C@H](OC(C)(C)C)C(=O)O)c(N2CCC(C)(C)CC2)c1-c1ccc(OCCc2ccc(F)cc2)cc1,J Med Chem,CHEMBL5093378,0.67,Yes,6.173925197
CHEMBL5050750,Inhibition of human ERG,Cc1cnc(Nc2ccnn2C)nc1-c1cc2n(c1)C(=O)N([C@H](CO)c1cccc(Cl)c1)C2,ACS Med Chem Lett,CHEMBL5070887,0.014,Yes,7.853871964
CHEMBL5054318,Inhibition of human ERG by flux assay,Cc1noc(C)c1-c1cnc2c3ccc(C(C)(C)O)cc3n([C@H](c3ccccc3)C3CCOCC3)c2c1,J Med Chem,CHEMBL5087175,51,No,4.292429824