I've been taking Alli with most meals for 5-6 weeks now, and I've lost about 10 pounds. I'm very happy with that and hope to continue. About the 3rd week, I did have the dreaded treatment effects (tacos are not a good idea, no matter how good they taste!). I think the medication is helping with weight loss, but I think it helps most with the motivation to ALWAYS eat less than 15g of fat at a meal. I've found a lot of alternatives that I didn't expect. I'm feeling better and finding it easier to keep up with the kids!