I use the slime lite in conjunction with Continental Touring Plus tires and I haven't changed a flat in almost two thousand miles. I highly recommend the slime lite for commuters, high mileage cyclist, or anyone who doesn't mind a little extra weight for the convenience. The only potential problem I can see is if you travel or ship your bike and need to let air out of the tires. The slime can come out and clog the valve, making it difficult to re-inflate or judge the air pressure while inflating. I encountered this with slime tubes and schrader valves on my mountain bike.