This product uses Senna, which when used overtime and too much can cause severe colon infractions in the gut, making it very uncomfortable. I've had some terrible experiences with deathly cramps and stabbing sensations in the gut from use of Senna; this isn't going to happen to everyone at any terms. It all comes down to rather the fact of how backed up you are and how healthy and staple your diet is.It's important to note the ingredients in this Cleansing product because there really are a lot of things to be aware of if you have any allergic tendencies.The Cleanse is suppose to be used with other products in a extended cleanse, which can be confusing as they aren't really listed on Amazon with the product, you might want to take a closer look if you were looking to pick the cleansing set up.