I read about Zyflamend over a year ago but only tried it about three months ago b/c it was on sale at a local place. I had runaway sytemic inflammation from a post-op hospital infection. I itched like crazy at night. I took antihistamines and NSAIDS together to try to alleviate the misery with so-so results. I started this product and to my astonishment it reduced my symptoms about 80% within a week. I now order the subscription from Amazon - best deal I have found. Just read the labels and doses. I get the regular caps and have no trouble with them. Take with a meal. If I don't drink enough water I will get reflux. That is simple to fix - drink a large glass of water with your meal. Another surprise: inflammation blood test called SED rate went from 14 to 4 in three months. I was surprised. My rheumatologist is completely disinterested in this product! I couldn't believe it. Listen up, docs!