I bought this product with the intention of using it with my 5-button MS USB wireless Intellimouse and wireless Logitech keyboard. The box and documentation imply that the KVM will work with any USM mouse. The problem I'm having with the KVM is randomly, the right click menu will appear. This happens enough be a major interruption while working...about every 20 seconds. After a few emails with IOGEAR's support manager, I got to the bottom of the story; this KVM only supports two button mice! This is not stated anywhere in the product description or manual!!! They have an "device emulation" feature that prevents lag time in device detection when switching between computers by emulating the mouse and keyboard connection; The KVM emulates a two button mouse and standard keyboard. Since it is not possible to upgrade the firmware on this KVM, the only advice the support manager could provide was to either use a 2-button mouse or return the KVM.