I am using this in a Mac running OS 10.3.8. If you already have previous versions of EndNote, e.g., 6.02, DO NOT upgrade. EndNote 8 is slow and unreliable and a waste of money. One area that I constantly run into trouble is the connection of EndNote to the PubMed server via the Internet. EndNote crashes frequently, and it seems to do so when Palm Desktop 4.2.1 is also running. If EndNote is finally connceted, it takes twice as long to download literatures as does v. 6.0.2. It is very frunstrating that new versions of the softwares do not aim at making themselves easy and reliable to use. Instead they add features that seem to benefit very few users. This is the key reason why I decide to write this review so that we can hold these companese responsible for their sloppy acts.