I've used Pro-Gest off and on for years since my TAHBSO in 1997 for endometriosis. Not being able to take any estrogen for six months post surgery, I used Pro-Gest when I started getting hot flashes and night sweats, within two weeks they were completely gone. I needed complete hormone supplementation after removal of uterus, ovaries, tubes and cervix. I used by prescription bioidentical compounded hormones. I tried oral progesterone (wasn't absorbing enough), transdermal progesterone (absorbed too much) so in addition to Bi Estrogen and Testosterone I also now use Pro-Gest so as not to be using unopposed estrogen and for progesterone's other benefits when one has had their ovaries removed. Paraben free and made by an awesome company, Emerita. This is the best price I've found for the 4oz tube.