I suppose this probably would to soothe diaper rash if it would actually spread. When you squeeze the tube, a ton of watery liquid comes out before the cream does, even if you shake it first. The cream doesn't spread. You have to mush it up between your fingers first but then it ends up sticking to your hands instead of baby's bum. Avoid this, it's nothing but an expensive ineffective mess. Usually I use Avalon Organics' zinc balm but I didn't want to have to order it online, so I picked up a couple tubes of this inthe store instead. What a joke!