I am hypothyroid and take 112 mcg Synthroid daily. I tried this hoping it would make maintaining my weight a little easier and would combat hair loss and brain fog. I did not have many of the other symptoms listed by people who bought this--cold hands and feet, fatigue, etc.--but wanted to optimize my regimen. I noticed no changes whatsoever.After giving this product all the time I could stand, I've concluded that this may be better suited for someone else: a person with a medically-untreated thyroid condition, or a thyroid condition with an underlying cause different from my own (radiation from Graves disease). Worth a try for the price, but may not be the miracle you need.