When Regina George discovers that her friend, Cady Heron, has developed a romantic interest in one of her significant others, she sets out to cripple Cady socially by taking him back. After a period of isolation, Cady finally approaches one of her other schoolmates, an outsider known as Janis who is the only person in North Shore who wants to counter any and all evil taking place within the system. What begins as a partnership between two characters, who would be unlikely to cross paths in the real world, quickly turns into a lifelong friendship. Together they manage to fight impossible odds to survive and prove that both hope and the possibility for redemption never die.